1B8JA

Alkaline phosphatase complexed with vanadate
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A model of the transition state in the alkaline phosphatase reaction.
pubmed doi rcsb
molecule tags Alkaline phosphatase
source organism Escherichia coli
molecule keywords PROTEIN (ALKALINE PHOSPHATASE)
total genus 163
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1999-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1b8jA00
4FDJA 4CXUA 3NKOA 2XR9A 4ZG7A 1N2KA 1KH5A 1HQAA 2W5SA 1SHNA 3ED4A 1AUKA 1AJCA 2QZUA 3IGZB 4LREA 3BDHA 5LIAA 3NKRA 4TN0A 4ZG6A 4NWXA 2D1GA 1ANJA 2XRGA 2W5VA 4GTXA 4CYSA 3UO0A 4GTWA 1HJKA 5INHA 4KJDA 4UPHA 1ZEFA 3E2DA 4FDIA 2IUCA 5GRRA 3MK0A 4QAXA 1ED9A 4KJGA 3DPCA 4CXKA 1E2SP 2W8DA 2GSNA 5IJQA 4UOOA 3IDDA 2W5XA 5GOVA 3LXQA 3BDGA 5DLVA 2VQRA 2W5QA 3NVLA 5C66A 4ZGAA 1FSUA 1EW9A 2X98A 2GA3A 5LRMA 2G9YA 4MY4A 4UOPA 1EI6A 3WAWA 4CXSA 4KAYA 3MK2A 3WAVA 1EW8A 1KHLA 4LR7A 1EJJA 4LRDA 3TX0A 1ELYA 1ELZA 4LR9A 5AJ9A 5L0EA 5LRNA 3M8YA 3UN3A 1EQJA 5HRTA 3SZZA 2GSOA 3OT9A 3WAXA 3B5QA 3T00A 3SZYA 4KM4A 3M7VA 3WBHA 4MIVA 2ZKTA 2W5RA 4UPIA 4YR1A 1ED8A 1EW2A 1KH9A 1O99A 4LRAA 3UN2A 1ELXA 1KH7A 4LRBA 4LQYA 2GSUA 5TJ3A 1E3CP 4CYRA 3NKMA 3KD8A 1Y7AA 1N2LA 1ALJA 4N7TA 3UNYA 4KAVA 3NKQA 4GTZA 1URAA 3M8ZA 3A52A 4UORA 4ZG9A 1SHQA 1Y6VA 2IUCB 1AJAA 4LR8A 1ANIA 2W5TA 1O98A 5L0KA 3DYCA 1P49A 2W8SA 3TWZA 2RH6A 1E33P 4LRCA 3TG0A 4GTYA 1AJBA 3IGYB 3NKNA 5IJSA 1HDHA 1E1ZP 4LR2A 1ZEDA 5L0BA 5LQQA 2IFYA 3BDGB 5KXAA 3CMRA 3UN5A 3M8WA 5EGHA 3BDFA 2GLQA 1ALIA 5EGEA 1ALHA 1K7HA 4LRFA 1KH4A 1KHKA 1KHJA 3NKPA 3WAYA 1AJDA 4UPLA 1URBA 5DLWA 2W5WA 4MHXA 1ZEBA 2ANHA 3MK1A 4UPKA 3T02A 3Q3QA 4B56A 5DLTA 5K4PA 4NWJA 3T01A 1ALKA 1B8JA 1KHNA
chains in the Genus database with same CATH superfamily
4FDJA 4CXUA 3NKOA 2XR9A 4ZG7A 1N2KA 1KH5A 1HQAA 2W5SA 1SHNA 3ED4A 1AUKA 1AJCA 2QZUA 3IGZB 4LREA 3BDHA 5LIAA 3NKRA 4TN0A 4ZG6A 4NWXA 2D1GA 1ANJA 2XRGA 2W5VA 4GTXA 4CYSA 3UO0A 4GTWA 1HJKA 5INHA 4KJDA 4UPHA 1ZEFA 3E2DA 4FDIA 2IUCA 5GRRA 3MK0A 4QAXA 1ED9A 4KJGA 3DPCA 4CXKA 1E2SP 2W8DA 2GSNA 5IJQA 4UOOA 3IDDA 2W5XA 5GOVA 3LXQA 3BDGA 5DLVA 2VQRA 2W5QA 3NVLA 5C66A 4ZGAA 1FSUA 1EW9A 2X98A 2GA3A 5LRMA 2G9YA 4MY4A 4UOPA 1EI6A 3WAWA 4CXSA 4KAYA 3MK2A 3WAVA 1EW8A 1KHLA 4LR7A 1EJJA 4LRDA 3TX0A 1ELYA 1ELZA 4LR9A 5AJ9A 5L0EA 5LRNA 3M8YA 3UN3A 1EQJA 5HRTA 3SZZA 2GSOA 3OT9A 3WAXA 3B5QA 3T00A 3SZYA 4KM4A 3M7VA 3WBHA 4MIVA 2ZKTA 2W5RA 4UPIA 4YR1A 1ED8A 1EW2A 1KH9A 1O99A 4LRAA 3UN2A 1ELXA 1KH7A 4LRBA 4LQYA 2GSUA 5TJ3A 1E3CP 4CYRA 3NKMA 3KD8A 1Y7AA 1N2LA 1ALJA 4N7TA 3UNYA 4KAVA 3NKQA 4GTZA 1URAA 3M8ZA 3A52A 4UORA 4ZG9A 1SHQA 1Y6VA 2IUCB 1AJAA 4LR8A 1ANIA 2W5TA 1O98A 5L0KA 3DYCA 1P49A 2W8SA 3TWZA 2RH6A 1E33P 4LRCA 3TG0A 4GTYA 1AJBA 3IGYB 3NKNA 5IJSA 1HDHA 1E1ZP 4LR2A 1ZEDA 5L0BA 5LQQA 2IFYA 3BDGB 5KXAA 3CMRA 3UN5A 3M8WA 5EGHA 3BDFA 2GLQA 1ALIA 5EGEA 1ALHA 1K7HA 4LRFA 1KH4A 1KHKA 1KHJA 3NKPA 3WAYA 1AJDA 4UPLA 1URBA 5DLWA 2W5WA 4MHXA 1ZEBA 2ANHA 3MK1A 4UPKA 3T02A 3Q3QA 4B56A 5DLTA 5K4PA 4NWJA 3T01A 1ALKA 1B8JA 1KHNA
chains in the Genus database with same CATH topology
4FDJA 4CXUA 3NKOA 2XR9A 4ZG7A 1N2KA 1KH5A 1HQAA 2W5SA 1SHNA 3ED4A 1AUKA 1AJCA 2QZUA 3IGZB 4LREA 3BDHA 5LIAA 3NKRA 4TN0A 4ZG6A 4NWXA 2D1GA 1ANJA 2XRGA 2W5VA 4GTXA 4CYSA 3UO0A 4GTWA 1HJKA 5INHA 4KJDA 4UPHA 1ZEFA 3E2DA 4FDIA 2IUCA 5GRRA 3MK0A 4QAXA 1ED9A 4KJGA 3DPCA 4CXKA 1E2SP 2W8DA 2GSNA 5IJQA 4UOOA 3IDDA 2W5XA 5GOVA 3LXQA 3BDGA 5DLVA 2VQRA 2W5QA 3NVLA 5C66A 4ZGAA 1FSUA 1EW9A 2X98A 2GA3A 5LRMA 2G9YA 4MY4A 4UOPA 1EI6A 3WAWA 4CXSA 4KAYA 3MK2A 3WAVA 1EW8A 1KHLA 4LR7A 1EJJA 4LRDA 3TX0A 1ELYA 1ELZA 4LR9A 5AJ9A 5L0EA 5LRNA 3M8YA 3UN3A 1EQJA 5HRTA 3SZZA 2GSOA 3OT9A 3WAXA 3B5QA 3T00A 3SZYA 4KM4A 3M7VA 3WBHA 4MIVA 2ZKTA 2W5RA 4UPIA 4YR1A 1ED8A 1EW2A 1KH9A 1O99A 4LRAA 3UN2A 1ELXA 1KH7A 4LRBA 4LQYA 2GSUA 5TJ3A 1E3CP 4CYRA 3NKMA 3KD8A 1Y7AA 1N2LA 1ALJA 4N7TA 3UNYA 4KAVA 3NKQA 4GTZA 1URAA 3M8ZA 3A52A 4UORA 4ZG9A 1SHQA 1Y6VA 2IUCB 1AJAA 4LR8A 1ANIA 2W5TA 1O98A 5L0KA 3DYCA 1P49A 2W8SA 3TWZA 2RH6A 1E33P 4LRCA 3TG0A 4GTYA 1AJBA 3IGYB 3NKNA 5IJSA 1HDHA 1E1ZP 4LR2A 1ZEDA 5L0BA 5LQQA 2IFYA 3BDGB 5KXAA 3CMRA 3UN5A 3M8WA 5EGHA 3BDFA 2GLQA 1ALIA 5EGEA 1ALHA 1K7HA 4LRFA 1KH4A 1KHKA 1KHJA 3NKPA 3WAYA 1AJDA 4UPLA 1URBA 5DLWA 2W5WA 4MHXA 1ZEBA 2ANHA 3MK1A 4UPKA 3T02A 3Q3QA 4B56A 5DLTA 5K4PA 4NWJA 3T01A 1ALKA 1B8JA 1KHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FDJ A;  4CXU A;  3NKO A;  2XR9 A;  4ZG7 A;  1N2K A;  1KH5 A;  1HQA A;  2W5S A;  1SHN A;  3ED4 A;  1AUK A;  1AJC A;  2QZU A;  3IGZ B;  4LRE A;  3BDH A;  5LIA A;  3NKR A;  4TN0 A;  4ZG6 A;  4NWX A;  2D1G A;  1ANJ A;  2XRG A;  2W5V A;  4GTX A;  4CYS A;  3UO0 A;  4GTW A;  1HJK A;  5INH A;  4KJD A;  4UPH A;  1ZEF A;  3E2D A;  4FDI A;  2IUC A;  5GRR A;  3MK0 A;  4QAX A;  1ED9 A;  4KJG A;  3DPC A;  4CXK A;  1E2S P;  2W8D A;  2GSN A;  5IJQ A;  4UOO A;  3IDD A;  2W5X A;  5GOV A;  3LXQ A;  3BDG A;  5DLV A;  2VQR A;  2W5Q A;  3NVL A;  5C66 A;  4ZGA A;  1FSU A;  1EW9 A;  2X98 A;  2GA3 A;  5LRM A;  2G9Y A;  4MY4 A;  4UOP A;  1EI6 A;  3WAW A;  4CXS A;  4KAY A;  3MK2 A;  3WAV A;  1EW8 A;  1KHL A;  4LR7 A;  1EJJ A;  4LRD A;  3TX0 A;  1ELY A;  1ELZ A;  4LR9 A;  5AJ9 A;  5L0E A;  5LRN A;  3M8Y A;  3UN3 A;  1EQJ A;  5HRT A;  3SZZ A;  2GSO A;  3OT9 A;  3WAX A;  3B5Q A;  3T00 A;  3SZY A;  4KM4 A;  3M7V A;  3WBH A;  4MIV A;  2ZKT A;  2W5R A;  4UPI A;  4YR1 A;  1ED8 A;  1EW2 A;  1KH9 A;  1O99 A;  4LRA A;  3UN2 A;  1ELX A;  1KH7 A;  4LRB A;  4LQY A;  2GSU A;  5TJ3 A;  1E3C P;  4CYR A;  3NKM A;  3KD8 A;  1Y7A A;  1N2L A;  1ALJ A;  4N7T A;  3UNY A;  4KAV A;  3NKQ A;  4GTZ A;  1URA A;  3M8Z A;  3A52 A;  4UOR A;  4ZG9 A;  1SHQ A;  1Y6V A;  2IUC B;  1AJA A;  4LR8 A;  1ANI A;  2W5T A;  1O98 A;  5L0K A;  3DYC A;  1P49 A;  2W8S A;  3TWZ A;  2RH6 A;  1E33 P;  4LRC A;  3TG0 A;  4GTY A;  1AJB A;  3IGY B;  3NKN A;  5IJS A;  1HDH A;  1E1Z P;  4LR2 A;  1ZED A;  5L0B A;  5LQQ A;  2IFY A;  3BDG B;  5KXA A;  3CMR A;  3UN5 A;  3M8W A;  5EGH A;  3BDF A;  2GLQ A;  1ALI A;  5EGE A;  1ALH A;  1K7H A;  4LRF A;  1KH4 A;  1KHK A;  1KHJ A;  3NKP A;  3WAY A;  1AJD A;  4UPL A;  1URB A;  5DLW A;  2W5W A;  4MHX A;  1ZEB A;  2ANH A;  3MK1 A;  4UPK A;  3T02 A;  3Q3Q A;  4B56 A;  5DLT A;  5K4P A;  4NWJ A;  3T01 A;  1ALK A;  1B8J A;  1KHN A; 
#chains in the Genus database with same CATH topology
 4FDJ A;  4CXU A;  3NKO A;  2XR9 A;  4ZG7 A;  1N2K A;  1KH5 A;  1HQA A;  2W5S A;  1SHN A;  3ED4 A;  1AUK A;  1AJC A;  2QZU A;  3IGZ B;  4LRE A;  3BDH A;  5LIA A;  3NKR A;  4TN0 A;  4ZG6 A;  4NWX A;  2D1G A;  1ANJ A;  2XRG A;  2W5V A;  4GTX A;  4CYS A;  3UO0 A;  4GTW A;  1HJK A;  5INH A;  4KJD A;  4UPH A;  1ZEF A;  3E2D A;  4FDI A;  2IUC A;  5GRR A;  3MK0 A;  4QAX A;  1ED9 A;  4KJG A;  3DPC A;  4CXK A;  1E2S P;  2W8D A;  2GSN A;  5IJQ A;  4UOO A;  3IDD A;  2W5X A;  5GOV A;  3LXQ A;  3BDG A;  5DLV A;  2VQR A;  2W5Q A;  3NVL A;  5C66 A;  4ZGA A;  1FSU A;  1EW9 A;  2X98 A;  2GA3 A;  5LRM A;  2G9Y A;  4MY4 A;  4UOP A;  1EI6 A;  3WAW A;  4CXS A;  4KAY A;  3MK2 A;  3WAV A;  1EW8 A;  1KHL A;  4LR7 A;  1EJJ A;  4LRD A;  3TX0 A;  1ELY A;  1ELZ A;  4LR9 A;  5AJ9 A;  5L0E A;  5LRN A;  3M8Y A;  3UN3 A;  1EQJ A;  5HRT A;  3SZZ A;  2GSO A;  3OT9 A;  3WAX A;  3B5Q A;  3T00 A;  3SZY A;  4KM4 A;  3M7V A;  3WBH A;  4MIV A;  2ZKT A;  2W5R A;  4UPI A;  4YR1 A;  1ED8 A;  1EW2 A;  1KH9 A;  1O99 A;  4LRA A;  3UN2 A;  1ELX A;  1KH7 A;  4LRB A;  4LQY A;  2GSU A;  5TJ3 A;  1E3C P;  4CYR A;  3NKM A;  3KD8 A;  1Y7A A;  1N2L A;  1ALJ A;  4N7T A;  3UNY A;  4KAV A;  3NKQ A;  4GTZ A;  1URA A;  3M8Z A;  3A52 A;  4UOR A;  4ZG9 A;  1SHQ A;  1Y6V A;  2IUC B;  1AJA A;  4LR8 A;  1ANI A;  2W5T A;  1O98 A;  5L0K A;  3DYC A;  1P49 A;  2W8S A;  3TWZ A;  2RH6 A;  1E33 P;  4LRC A;  3TG0 A;  4GTY A;  1AJB A;  3IGY B;  3NKN A;  5IJS A;  1HDH A;  1E1Z P;  4LR2 A;  1ZED A;  5L0B A;  5LQQ A;  2IFY A;  3BDG B;  5KXA A;  3CMR A;  3UN5 A;  3M8W A;  5EGH A;  3BDF A;  2GLQ A;  1ALI A;  5EGE A;  1ALH A;  1K7H A;  4LRF A;  1KH4 A;  1KHK A;  1KHJ A;  3NKP A;  3WAY A;  1AJD A;  4UPL A;  1URB A;  5DLW A;  2W5W A;  4MHX A;  1ZEB A;  2ANH A;  3MK1 A;  4UPK A;  3T02 A;  3Q3Q A;  4B56 A;  5DLT A;  5K4P A;  4NWJ A;  3T01 A;  1ALK A;  1B8J A;  1KHN A; 
#chains in the Genus database with same CATH homology
 4FDJ A;  4CXU A;  3NKO A;  2XR9 A;  4ZG7 A;  1N2K A;  1KH5 A;  1HQA A;  2W5S A;  1SHN A;  3ED4 A;  1AUK A;  1AJC A;  2QZU A;  3IGZ B;  4LRE A;  3BDH A;  5LIA A;  3NKR A;  4TN0 A;  4ZG6 A;  4NWX A;  2D1G A;  1ANJ A;  2XRG A;  2W5V A;  4GTX A;  4CYS A;  3UO0 A;  4GTW A;  1HJK A;  5INH A;  4KJD A;  4UPH A;  1ZEF A;  3E2D A;  4FDI A;  2IUC A;  5GRR A;  3MK0 A;  4QAX A;  1ED9 A;  4KJG A;  3DPC A;  4CXK A;  1E2S P;  2W8D A;  2GSN A;  5IJQ A;  4UOO A;  3IDD A;  2W5X A;  5GOV A;  3LXQ A;  3BDG A;  5DLV A;  2VQR A;  2W5Q A;  3NVL A;  5C66 A;  4ZGA A;  1FSU A;  1EW9 A;  2X98 A;  2GA3 A;  5LRM A;  2G9Y A;  4MY4 A;  4UOP A;  1EI6 A;  3WAW A;  4CXS A;  4KAY A;  3MK2 A;  3WAV A;  1EW8 A;  1KHL A;  4LR7 A;  1EJJ A;  4LRD A;  3TX0 A;  1ELY A;  1ELZ A;  4LR9 A;  5AJ9 A;  5L0E A;  5LRN A;  3M8Y A;  3UN3 A;  1EQJ A;  5HRT A;  3SZZ A;  2GSO A;  3OT9 A;  3WAX A;  3B5Q A;  3T00 A;  3SZY A;  4KM4 A;  3M7V A;  3WBH A;  4MIV A;  2ZKT A;  2W5R A;  4UPI A;  4YR1 A;  1ED8 A;  1EW2 A;  1KH9 A;  1O99 A;  4LRA A;  3UN2 A;  1ELX A;  1KH7 A;  4LRB A;  4LQY A;  2GSU A;  5TJ3 A;  1E3C P;  4CYR A;  3NKM A;  3KD8 A;  1Y7A A;  1N2L A;  1ALJ A;  4N7T A;  3UNY A;  4KAV A;  3NKQ A;  4GTZ A;  1URA A;  3M8Z A;  3A52 A;  4UOR A;  4ZG9 A;  1SHQ A;  1Y6V A;  2IUC B;  1AJA A;  4LR8 A;  1ANI A;  2W5T A;  1O98 A;  5L0K A;  3DYC A;  1P49 A;  2W8S A;  3TWZ A;  2RH6 A;  1E33 P;  4LRC A;  3TG0 A;  4GTY A;  1AJB A;  3IGY B;  3NKN A;  5IJS A;  1HDH A;  1E1Z P;  4LR2 A;  1ZED A;  5L0B A;  5LQQ A;  2IFY A;  3BDG B;  5KXA A;  3CMR A;  3UN5 A;  3M8W A;  5EGH A;  3BDF A;  2GLQ A;  1ALI A;  5EGE A;  1ALH A;  1K7H A;  4LRF A;  1KH4 A;  1KHK A;  1KHJ A;  3NKP A;  3WAY A;  1AJD A;  4UPL A;  1URB A;  5DLW A;  2W5W A;  4MHX A;  1ZEB A;  2ANH A;  3MK1 A;  4UPK A;  3T02 A;  3Q3Q A;  4B56 A;  5DLT A;  5K4P A;  4NWJ A;  3T01 A;  1ALK A;  1B8J A;  1KHN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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