1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
2GLQA 3IGZB 1E1ZP 2W5WA 2QZUA 2G9YA 1EJJA 1HJKA 4CYRA 2IUCB 1Y6VA 2XR9A 3MK0A 1ANJA 4KJGA 4LQYA 4ZG6A 4UPKA 1KHJA 1EW8A 3UNYA 3CMRA 1B8JA 4ZG7A 2RH6A 2GSOA 3WBHA 3BDFA 4YR1A 3SZYA 3IDDA 3UN5A 1HDHA 3WAWA 3BDGA 5IJSA 1ED9A 3NVLA 3M8ZA 4LRFA 2VQRA 2GA3A 1ZEDA 4KJDA 4UPLA 1SHQA 1AUKA 2W5QA 3T01A 5L0BA 4CXSA 5LIAA 1KHKA 4LREA 1KHNA 3A52A 4UPIA 3WAXA 4KM4A 4ZGAA 1E3CP 3NKPA 1EQJA 2W5XA 4CYSA 2D1GA 5IJQA 3WAYA 5GRRA 5K4PA 4KAYA 1EW9A 3T02A 1ALJA 1KH7A 2XRGA 2IUCA 3M8YA 5C66A 5GOVA 1FSUA 1AJAA 4LR7A 5DLVA 3DPCA 1ELYA 1ALHA 3TG0A 3IGYB 4CXKA 3M7VA 4LRCA 4LR9A 4B56A 2GSUA 1ALKA 1ELXA 1AJBA 3TX0A 1ALIA 1E33P 4GTXA 4NWJA 4LRBA 5KXAA 4QAXA 5DLWA 4GTZA 3ED4A 4GTYA 1Y7AA 1ELZA 3KD8A 4LR2A 1KH4A 5TJ3A 3WAVA 2GSNA 3B5QA 4KAVA 1N2LA 3BDHA 5EGHA 1EW2A 3MK2A 4FDIA 3TWZA 2W5SA 3BDGB 3OT9A 5EGEA 1ED8A 5AJ9A 1O99A 1P49A 4NWXA 1KHLA 1AJCA 3NKRA 1URAA 3MK1A 4TN0A 4UPHA 4CXUA 5DLTA 4UORA 1KH9A 3SZZA 4LRAA 3NKMA 4GTWA 4LR8A 2W8DA 2W5RA 3Q3QA 3M8WA 1HQAA 2ANHA 3NKOA 4MHXA 4N7TA 4FDJA 3UO0A 3UN3A 5L0KA 5LRNA 3LXQA 1E2SP 4UOPA 2W5TA 5LQQA 4LRDA 3E2DA 1EI6A 3UN2A 4MIVA 5INHA 3NKNA 2X98A 1SHNA 1N2KA 1KH5A 3NKQA 5HRTA 1AJDA 4UOOA 1ZEFA 2W5VA 2W8SA 3DYCA 1O98A 5LRMA 1URBA 1ZEBA 2ZKTA 1K7HA 5L0EA 1ANIA 4ZG9A 3T00A 4MY4A 2IFYA
chains in the Genus database with same CATH superfamily
2GLQA 3IGZB 1E1ZP 2W5WA 2QZUA 2G9YA 1EJJA 1HJKA 4CYRA 2IUCB 1Y6VA 2XR9A 3MK0A 1ANJA 4KJGA 4LQYA 4ZG6A 4UPKA 1KHJA 1EW8A 3UNYA 3CMRA 1B8JA 4ZG7A 2RH6A 2GSOA 3WBHA 3BDFA 4YR1A 3SZYA 3IDDA 3UN5A 1HDHA 3WAWA 3BDGA 5IJSA 1ED9A 3NVLA 3M8ZA 4LRFA 2VQRA 2GA3A 1ZEDA 4KJDA 4UPLA 1SHQA 1AUKA 2W5QA 3T01A 5L0BA 4CXSA 5LIAA 1KHKA 4LREA 1KHNA 3A52A 4UPIA 3WAXA 4KM4A 4ZGAA 1E3CP 3NKPA 1EQJA 2W5XA 4CYSA 2D1GA 5IJQA 3WAYA 5GRRA 5K4PA 4KAYA 1EW9A 3T02A 1ALJA 1KH7A 2XRGA 2IUCA 3M8YA 5C66A 5GOVA 1FSUA 1AJAA 4LR7A 5DLVA 3DPCA 1ELYA 1ALHA 3TG0A 3IGYB 4CXKA 3M7VA 4LRCA 4LR9A 4B56A 2GSUA 1ALKA 1ELXA 1AJBA 3TX0A 1ALIA 1E33P 4GTXA 4NWJA 4LRBA 5KXAA 4QAXA 5DLWA 4GTZA 3ED4A 4GTYA 1Y7AA 1ELZA 3KD8A 4LR2A 1KH4A 5TJ3A 3WAVA 2GSNA 3B5QA 4KAVA 1N2LA 3BDHA 5EGHA 1EW2A 3MK2A 4FDIA 3TWZA 2W5SA 3BDGB 3OT9A 5EGEA 1ED8A 5AJ9A 1O99A 1P49A 4NWXA 1KHLA 1AJCA 3NKRA 1URAA 3MK1A 4TN0A 4UPHA 4CXUA 5DLTA 4UORA 1KH9A 3SZZA 4LRAA 3NKMA 4GTWA 4LR8A 2W8DA 2W5RA 3Q3QA 3M8WA 1HQAA 2ANHA 3NKOA 4MHXA 4N7TA 4FDJA 3UO0A 3UN3A 5L0KA 5LRNA 3LXQA 1E2SP 4UOPA 2W5TA 5LQQA 4LRDA 3E2DA 1EI6A 3UN2A 4MIVA 5INHA 3NKNA 2X98A 1SHNA 1N2KA 1KH5A 3NKQA 5HRTA 1AJDA 4UOOA 1ZEFA 2W5VA 2W8SA 3DYCA 1O98A 5LRMA 1URBA 1ZEBA 2ZKTA 1K7HA 5L0EA 1ANIA 4ZG9A 3T00A 4MY4A 2IFYA
chains in the Genus database with same CATH topology
2GLQA 3IGZB 1E1ZP 2W5WA 2QZUA 2G9YA 1EJJA 1HJKA 4CYRA 2IUCB 1Y6VA 2XR9A 3MK0A 1ANJA 4KJGA 4LQYA 4ZG6A 4UPKA 1KHJA 1EW8A 3UNYA 3CMRA 1B8JA 4ZG7A 2RH6A 2GSOA 3WBHA 3BDFA 4YR1A 3SZYA 3IDDA 3UN5A 1HDHA 3WAWA 3BDGA 5IJSA 1ED9A 3NVLA 3M8ZA 4LRFA 2VQRA 2GA3A 1ZEDA 4KJDA 4UPLA 1SHQA 1AUKA 2W5QA 3T01A 5L0BA 4CXSA 5LIAA 1KHKA 4LREA 1KHNA 3A52A 4UPIA 3WAXA 4KM4A 4ZGAA 1E3CP 3NKPA 1EQJA 2W5XA 4CYSA 2D1GA 5IJQA 3WAYA 5GRRA 5K4PA 4KAYA 1EW9A 3T02A 1ALJA 1KH7A 2XRGA 2IUCA 3M8YA 5C66A 5GOVA 1FSUA 1AJAA 4LR7A 5DLVA 3DPCA 1ELYA 1ALHA 3TG0A 3IGYB 4CXKA 3M7VA 4LRCA 4LR9A 4B56A 2GSUA 1ALKA 1ELXA 1AJBA 3TX0A 1ALIA 1E33P 4GTXA 4NWJA 4LRBA 5KXAA 4QAXA 5DLWA 4GTZA 3ED4A 4GTYA 1Y7AA 1ELZA 3KD8A 4LR2A 1KH4A 5TJ3A 3WAVA 2GSNA 3B5QA 4KAVA 1N2LA 3BDHA 5EGHA 1EW2A 3MK2A 4FDIA 3TWZA 2W5SA 3BDGB 3OT9A 5EGEA 1ED8A 5AJ9A 1O99A 1P49A 4NWXA 1KHLA 1AJCA 3NKRA 1URAA 3MK1A 4TN0A 4UPHA 4CXUA 5DLTA 4UORA 1KH9A 3SZZA 4LRAA 3NKMA 4GTWA 4LR8A 2W8DA 2W5RA 3Q3QA 3M8WA 1HQAA 2ANHA 3NKOA 4MHXA 4N7TA 4FDJA 3UO0A 3UN3A 5L0KA 5LRNA 3LXQA 1E2SP 4UOPA 2W5TA 5LQQA 4LRDA 3E2DA 1EI6A 3UN2A 4MIVA 5INHA 3NKNA 2X98A 1SHNA 1N2KA 1KH5A 3NKQA 5HRTA 1AJDA 4UOOA 1ZEFA 2W5VA 2W8SA 3DYCA 1O98A 5LRMA 1URBA 1ZEBA 2ZKTA 1K7HA 5L0EA 1ANIA 4ZG9A 3T00A 4MY4A 2IFYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GLQ A;  3IGZ B;  1E1Z P;  2W5W A;  2QZU A;  2G9Y A;  1EJJ A;  1HJK A;  4CYR A;  2IUC B;  1Y6V A;  2XR9 A;  3MK0 A;  1ANJ A;  4KJG A;  4LQY A;  4ZG6 A;  4UPK A;  1KHJ A;  1EW8 A;  3UNY A;  3CMR A;  1B8J A;  4ZG7 A;  2RH6 A;  2GSO A;  3WBH A;  3BDF A;  4YR1 A;  3SZY A;  3IDD A;  3UN5 A;  1HDH A;  3WAW A;  3BDG A;  5IJS A;  1ED9 A;  3NVL A;  3M8Z A;  4LRF A;  2VQR A;  2GA3 A;  1ZED A;  4KJD A;  4UPL A;  1SHQ A;  1AUK A;  2W5Q A;  3T01 A;  5L0B A;  4CXS A;  5LIA A;  1KHK A;  4LRE A;  1KHN A;  3A52 A;  4UPI A;  3WAX A;  4KM4 A;  4ZGA A;  1E3C P;  3NKP A;  1EQJ A;  2W5X A;  4CYS A;  2D1G A;  5IJQ A;  3WAY A;  5GRR A;  5K4P A;  4KAY A;  1EW9 A;  3T02 A;  1ALJ A;  1KH7 A;  2XRG A;  2IUC A;  3M8Y A;  5C66 A;  5GOV A;  1FSU A;  1AJA A;  4LR7 A;  5DLV A;  3DPC A;  1ELY A;  1ALH A;  3TG0 A;  3IGY B;  4CXK A;  3M7V A;  4LRC A;  4LR9 A;  4B56 A;  2GSU A;  1ALK A;  1ELX A;  1AJB A;  3TX0 A;  1ALI A;  1E33 P;  4GTX A;  4NWJ A;  4LRB A;  5KXA A;  4QAX A;  5DLW A;  4GTZ A;  3ED4 A;  4GTY A;  1Y7A A;  1ELZ A;  3KD8 A;  4LR2 A;  1KH4 A;  5TJ3 A;  3WAV A;  2GSN A;  3B5Q A;  4KAV A;  1N2L A;  3BDH A;  5EGH A;  1EW2 A;  3MK2 A;  4FDI A;  3TWZ A;  2W5S A;  3BDG B;  3OT9 A;  5EGE A;  1ED8 A;  5AJ9 A;  1O99 A;  1P49 A;  4NWX A;  1KHL A;  1AJC A;  3NKR A;  1URA A;  3MK1 A;  4TN0 A;  4UPH A;  4CXU A;  5DLT A;  4UOR A;  1KH9 A;  3SZZ A;  4LRA A;  3NKM A;  4GTW A;  4LR8 A;  2W8D A;  2W5R A;  3Q3Q A;  3M8W A;  1HQA A;  2ANH A;  3NKO A;  4MHX A;  4N7T A;  4FDJ A;  3UO0 A;  3UN3 A;  5L0K A;  5LRN A;  3LXQ A;  1E2S P;  4UOP A;  2W5T A;  5LQQ A;  4LRD A;  3E2D A;  1EI6 A;  3UN2 A;  4MIV A;  5INH A;  3NKN A;  2X98 A;  1SHN A;  1N2K A;  1KH5 A;  3NKQ A;  5HRT A;  1AJD A;  4UOO A;  1ZEF A;  2W5V A;  2W8S A;  3DYC A;  1O98 A;  5LRM A;  1URB A;  1ZEB A;  2ZKT A;  1K7H A;  5L0E A;  1ANI A;  4ZG9 A;  3T00 A;  4MY4 A;  2IFY A; 
#chains in the Genus database with same CATH topology
 2GLQ A;  3IGZ B;  1E1Z P;  2W5W A;  2QZU A;  2G9Y A;  1EJJ A;  1HJK A;  4CYR A;  2IUC B;  1Y6V A;  2XR9 A;  3MK0 A;  1ANJ A;  4KJG A;  4LQY A;  4ZG6 A;  4UPK A;  1KHJ A;  1EW8 A;  3UNY A;  3CMR A;  1B8J A;  4ZG7 A;  2RH6 A;  2GSO A;  3WBH A;  3BDF A;  4YR1 A;  3SZY A;  3IDD A;  3UN5 A;  1HDH A;  3WAW A;  3BDG A;  5IJS A;  1ED9 A;  3NVL A;  3M8Z A;  4LRF A;  2VQR A;  2GA3 A;  1ZED A;  4KJD A;  4UPL A;  1SHQ A;  1AUK A;  2W5Q A;  3T01 A;  5L0B A;  4CXS A;  5LIA A;  1KHK A;  4LRE A;  1KHN A;  3A52 A;  4UPI A;  3WAX A;  4KM4 A;  4ZGA A;  1E3C P;  3NKP A;  1EQJ A;  2W5X A;  4CYS A;  2D1G A;  5IJQ A;  3WAY A;  5GRR A;  5K4P A;  4KAY A;  1EW9 A;  3T02 A;  1ALJ A;  1KH7 A;  2XRG A;  2IUC A;  3M8Y A;  5C66 A;  5GOV A;  1FSU A;  1AJA A;  4LR7 A;  5DLV A;  3DPC A;  1ELY A;  1ALH A;  3TG0 A;  3IGY B;  4CXK A;  3M7V A;  4LRC A;  4LR9 A;  4B56 A;  2GSU A;  1ALK A;  1ELX A;  1AJB A;  3TX0 A;  1ALI A;  1E33 P;  4GTX A;  4NWJ A;  4LRB A;  5KXA A;  4QAX A;  5DLW A;  4GTZ A;  3ED4 A;  4GTY A;  1Y7A A;  1ELZ A;  3KD8 A;  4LR2 A;  1KH4 A;  5TJ3 A;  3WAV A;  2GSN A;  3B5Q A;  4KAV A;  1N2L A;  3BDH A;  5EGH A;  1EW2 A;  3MK2 A;  4FDI A;  3TWZ A;  2W5S A;  3BDG B;  3OT9 A;  5EGE A;  1ED8 A;  5AJ9 A;  1O99 A;  1P49 A;  4NWX A;  1KHL A;  1AJC A;  3NKR A;  1URA A;  3MK1 A;  4TN0 A;  4UPH A;  4CXU A;  5DLT A;  4UOR A;  1KH9 A;  3SZZ A;  4LRA A;  3NKM A;  4GTW A;  4LR8 A;  2W8D A;  2W5R A;  3Q3Q A;  3M8W A;  1HQA A;  2ANH A;  3NKO A;  4MHX A;  4N7T A;  4FDJ A;  3UO0 A;  3UN3 A;  5L0K A;  5LRN A;  3LXQ A;  1E2S P;  4UOP A;  2W5T A;  5LQQ A;  4LRD A;  3E2D A;  1EI6 A;  3UN2 A;  4MIV A;  5INH A;  3NKN A;  2X98 A;  1SHN A;  1N2K A;  1KH5 A;  3NKQ A;  5HRT A;  1AJD A;  4UOO A;  1ZEF A;  2W5V A;  2W8S A;  3DYC A;  1O98 A;  5LRM A;  1URB A;  1ZEB A;  2ZKT A;  1K7H A;  5L0E A;  1ANI A;  4ZG9 A;  3T00 A;  4MY4 A;  2IFY A; 
#chains in the Genus database with same CATH homology
 2GLQ A;  3IGZ B;  1E1Z P;  2W5W A;  2QZU A;  2G9Y A;  1EJJ A;  1HJK A;  4CYR A;  2IUC B;  1Y6V A;  2XR9 A;  3MK0 A;  1ANJ A;  4KJG A;  4LQY A;  4ZG6 A;  4UPK A;  1KHJ A;  1EW8 A;  3UNY A;  3CMR A;  1B8J A;  4ZG7 A;  2RH6 A;  2GSO A;  3WBH A;  3BDF A;  4YR1 A;  3SZY A;  3IDD A;  3UN5 A;  1HDH A;  3WAW A;  3BDG A;  5IJS A;  1ED9 A;  3NVL A;  3M8Z A;  4LRF A;  2VQR A;  2GA3 A;  1ZED A;  4KJD A;  4UPL A;  1SHQ A;  1AUK A;  2W5Q A;  3T01 A;  5L0B A;  4CXS A;  5LIA A;  1KHK A;  4LRE A;  1KHN A;  3A52 A;  4UPI A;  3WAX A;  4KM4 A;  4ZGA A;  1E3C P;  3NKP A;  1EQJ A;  2W5X A;  4CYS A;  2D1G A;  5IJQ A;  3WAY A;  5GRR A;  5K4P A;  4KAY A;  1EW9 A;  3T02 A;  1ALJ A;  1KH7 A;  2XRG A;  2IUC A;  3M8Y A;  5C66 A;  5GOV A;  1FSU A;  1AJA A;  4LR7 A;  5DLV A;  3DPC A;  1ELY A;  1ALH A;  3TG0 A;  3IGY B;  4CXK A;  3M7V A;  4LRC A;  4LR9 A;  4B56 A;  2GSU A;  1ALK A;  1ELX A;  1AJB A;  3TX0 A;  1ALI A;  1E33 P;  4GTX A;  4NWJ A;  4LRB A;  5KXA A;  4QAX A;  5DLW A;  4GTZ A;  3ED4 A;  4GTY A;  1Y7A A;  1ELZ A;  3KD8 A;  4LR2 A;  1KH4 A;  5TJ3 A;  3WAV A;  2GSN A;  3B5Q A;  4KAV A;  1N2L A;  3BDH A;  5EGH A;  1EW2 A;  3MK2 A;  4FDI A;  3TWZ A;  2W5S A;  3BDG B;  3OT9 A;  5EGE A;  1ED8 A;  5AJ9 A;  1O99 A;  1P49 A;  4NWX A;  1KHL A;  1AJC A;  3NKR A;  1URA A;  3MK1 A;  4TN0 A;  4UPH A;  4CXU A;  5DLT A;  4UOR A;  1KH9 A;  3SZZ A;  4LRA A;  3NKM A;  4GTW A;  4LR8 A;  2W8D A;  2W5R A;  3Q3Q A;  3M8W A;  1HQA A;  2ANH A;  3NKO A;  4MHX A;  4N7T A;  4FDJ A;  3UO0 A;  3UN3 A;  5L0K A;  5LRN A;  3LXQ A;  1E2S P;  4UOP A;  2W5T A;  5LQQ A;  4LRD A;  3E2D A;  1EI6 A;  3UN2 A;  4MIV A;  5INH A;  3NKN A;  2X98 A;  1SHN A;  1N2K A;  1KH5 A;  3NKQ A;  5HRT A;  1AJD A;  4UOO A;  1ZEF A;  2W5V A;  2W8S A;  3DYC A;  1O98 A;  5LRM A;  1URB A;  1ZEB A;  2ZKT A;  1K7H A;  5L0E A;  1ANI A;  4ZG9 A;  3T00 A;  4MY4 A;  2IFY A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite