1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
1FSUA 1AJBA 4UORA 3M8ZA 2GLQA 1Y7AA 3WAVA 1EQJA 2W5VA 3NKQA 2GSOA 2GA3A 3BDFA 1EW9A 1E3CP 4QAXA 4MHXA 1HJKA 3T00A 1HDHA 1KH5A 2QZUA 3Q3QA 1ALKA 4CYRA 3IGYB 4LREA 3MK2A 4NWXA 5GOVA 3M7VA 3M8YA 1B8JA 1ANJA 2IUCA 4LRDA 1EJJA 5AJ9A 1O99A 1ALIA 2XRGA 3E2DA 3LXQA 3UN3A 1EW2A 4KJGA 4UPKA 3UO0A 5IJSA 1AJCA 2G9YA 3OT9A 4UPIA 1URBA 1E2SP 2IFYA 3NKMA 1ELYA 2W5WA 3T01A 1SHQA 3WAXA 3NKPA 1KH9A 2W8SA 3DYCA 3T02A 4UOOA 5IJQA 3BDGB 3BDHA 1KHNA 3M8WA 3IDDA 3BDGA 5DLTA 3NKNA 1ALJA 4KM4A 1ED9A 5LQQA 4LR9A 3SZYA 1ALHA 1Y6VA 4LRAA 3IGZB 4NWJA 3UNYA 4TN0A 4GTWA 5DLVA 1SHNA 3B5QA 4MY4A 4FDIA 5L0EA 5LIAA 2W5XA 1AJDA 2ZKTA 2W5TA 5L0BA 1ZEDA 1HQAA 2D1GA 4LRBA 3A52A 4LRCA 4UPHA 4KAYA 1AUKA 4ZG9A 3TWZA 4ZGAA 1O98A 1ELZA 3MK0A 3WAWA 3NKRA 1K7HA 2W5RA 4UOPA 5INHA 5LRMA 1ELXA 4B56A 1P49A 4LR7A 2X98A 5L0KA 1KH7A 3WAYA 3KD8A 4ZG7A 1E33P 5K4PA 3NKOA 3WBHA 1EW8A 1ED8A 3CMRA 4GTYA 2W5SA 2XR9A 5C66A 3TG0A 1N2KA 4LR2A 1N2LA 3SZZA 5EGEA 4UPLA 5LRNA 4YR1A 5HRTA 1ZEBA 1ANIA 3NVLA 1ZEFA 3ED4A 4MIVA 1KH4A 5KXAA 4FDJA 1E1ZP 1KHKA 5DLWA 3TX0A 2RH6A 4KAVA 5TJ3A 4CXUA 4CXKA 2ANHA 4GTXA 4N7TA 4LQYA 2VQRA 1AJAA 3MK1A 5GRRA 4LRFA 4CYSA 2IUCB 2W8DA 2W5QA 4GTZA 3UN2A 1URAA 1KHJA 4KJDA 4CXSA 5EGHA 2GSNA 3UN5A 1EI6A 1KHLA 3DPCA 4ZG6A 2GSUA 4LR8A
chains in the Genus database with same CATH superfamily
1FSUA 1AJBA 4UORA 3M8ZA 2GLQA 1Y7AA 3WAVA 1EQJA 2W5VA 3NKQA 2GSOA 2GA3A 3BDFA 1EW9A 1E3CP 4QAXA 4MHXA 1HJKA 3T00A 1HDHA 1KH5A 2QZUA 3Q3QA 1ALKA 4CYRA 3IGYB 4LREA 3MK2A 4NWXA 5GOVA 3M7VA 3M8YA 1B8JA 1ANJA 2IUCA 4LRDA 1EJJA 5AJ9A 1O99A 1ALIA 2XRGA 3E2DA 3LXQA 3UN3A 1EW2A 4KJGA 4UPKA 3UO0A 5IJSA 1AJCA 2G9YA 3OT9A 4UPIA 1URBA 1E2SP 2IFYA 3NKMA 1ELYA 2W5WA 3T01A 1SHQA 3WAXA 3NKPA 1KH9A 2W8SA 3DYCA 3T02A 4UOOA 5IJQA 3BDGB 3BDHA 1KHNA 3M8WA 3IDDA 3BDGA 5DLTA 3NKNA 1ALJA 4KM4A 1ED9A 5LQQA 4LR9A 3SZYA 1ALHA 1Y6VA 4LRAA 3IGZB 4NWJA 3UNYA 4TN0A 4GTWA 5DLVA 1SHNA 3B5QA 4MY4A 4FDIA 5L0EA 5LIAA 2W5XA 1AJDA 2ZKTA 2W5TA 5L0BA 1ZEDA 1HQAA 2D1GA 4LRBA 3A52A 4LRCA 4UPHA 4KAYA 1AUKA 4ZG9A 3TWZA 4ZGAA 1O98A 1ELZA 3MK0A 3WAWA 3NKRA 1K7HA 2W5RA 4UOPA 5INHA 5LRMA 1ELXA 4B56A 1P49A 4LR7A 2X98A 5L0KA 1KH7A 3WAYA 3KD8A 4ZG7A 1E33P 5K4PA 3NKOA 3WBHA 1EW8A 1ED8A 3CMRA 4GTYA 2W5SA 2XR9A 5C66A 3TG0A 1N2KA 4LR2A 1N2LA 3SZZA 5EGEA 4UPLA 5LRNA 4YR1A 5HRTA 1ZEBA 1ANIA 3NVLA 1ZEFA 3ED4A 4MIVA 1KH4A 5KXAA 4FDJA 1E1ZP 1KHKA 5DLWA 3TX0A 2RH6A 4KAVA 5TJ3A 4CXUA 4CXKA 2ANHA 4GTXA 4N7TA 4LQYA 2VQRA 1AJAA 3MK1A 5GRRA 4LRFA 4CYSA 2IUCB 2W8DA 2W5QA 4GTZA 3UN2A 1URAA 1KHJA 4KJDA 4CXSA 5EGHA 2GSNA 3UN5A 1EI6A 1KHLA 3DPCA 4ZG6A 2GSUA 4LR8A
chains in the Genus database with same CATH topology
1FSUA 1AJBA 4UORA 3M8ZA 2GLQA 1Y7AA 3WAVA 1EQJA 2W5VA 3NKQA 2GSOA 2GA3A 3BDFA 1EW9A 1E3CP 4QAXA 4MHXA 1HJKA 3T00A 1HDHA 1KH5A 2QZUA 3Q3QA 1ALKA 4CYRA 3IGYB 4LREA 3MK2A 4NWXA 5GOVA 3M7VA 3M8YA 1B8JA 1ANJA 2IUCA 4LRDA 1EJJA 5AJ9A 1O99A 1ALIA 2XRGA 3E2DA 3LXQA 3UN3A 1EW2A 4KJGA 4UPKA 3UO0A 5IJSA 1AJCA 2G9YA 3OT9A 4UPIA 1URBA 1E2SP 2IFYA 3NKMA 1ELYA 2W5WA 3T01A 1SHQA 3WAXA 3NKPA 1KH9A 2W8SA 3DYCA 3T02A 4UOOA 5IJQA 3BDGB 3BDHA 1KHNA 3M8WA 3IDDA 3BDGA 5DLTA 3NKNA 1ALJA 4KM4A 1ED9A 5LQQA 4LR9A 3SZYA 1ALHA 1Y6VA 4LRAA 3IGZB 4NWJA 3UNYA 4TN0A 4GTWA 5DLVA 1SHNA 3B5QA 4MY4A 4FDIA 5L0EA 5LIAA 2W5XA 1AJDA 2ZKTA 2W5TA 5L0BA 1ZEDA 1HQAA 2D1GA 4LRBA 3A52A 4LRCA 4UPHA 4KAYA 1AUKA 4ZG9A 3TWZA 4ZGAA 1O98A 1ELZA 3MK0A 3WAWA 3NKRA 1K7HA 2W5RA 4UOPA 5INHA 5LRMA 1ELXA 4B56A 1P49A 4LR7A 2X98A 5L0KA 1KH7A 3WAYA 3KD8A 4ZG7A 1E33P 5K4PA 3NKOA 3WBHA 1EW8A 1ED8A 3CMRA 4GTYA 2W5SA 2XR9A 5C66A 3TG0A 1N2KA 4LR2A 1N2LA 3SZZA 5EGEA 4UPLA 5LRNA 4YR1A 5HRTA 1ZEBA 1ANIA 3NVLA 1ZEFA 3ED4A 4MIVA 1KH4A 5KXAA 4FDJA 1E1ZP 1KHKA 5DLWA 3TX0A 2RH6A 4KAVA 5TJ3A 4CXUA 4CXKA 2ANHA 4GTXA 4N7TA 4LQYA 2VQRA 1AJAA 3MK1A 5GRRA 4LRFA 4CYSA 2IUCB 2W8DA 2W5QA 4GTZA 3UN2A 1URAA 1KHJA 4KJDA 4CXSA 5EGHA 2GSNA 3UN5A 1EI6A 1KHLA 3DPCA 4ZG6A 2GSUA 4LR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FSU A;  1AJB A;  4UOR A;  3M8Z A;  2GLQ A;  1Y7A A;  3WAV A;  1EQJ A;  2W5V A;  3NKQ A;  2GSO A;  2GA3 A;  3BDF A;  1EW9 A;  1E3C P;  4QAX A;  4MHX A;  1HJK A;  3T00 A;  1HDH A;  1KH5 A;  2QZU A;  3Q3Q A;  1ALK A;  4CYR A;  3IGY B;  4LRE A;  3MK2 A;  4NWX A;  5GOV A;  3M7V A;  3M8Y A;  1B8J A;  1ANJ A;  2IUC A;  4LRD A;  1EJJ A;  5AJ9 A;  1O99 A;  1ALI A;  2XRG A;  3E2D A;  3LXQ A;  3UN3 A;  1EW2 A;  4KJG A;  4UPK A;  3UO0 A;  5IJS A;  1AJC A;  2G9Y A;  3OT9 A;  4UPI A;  1URB A;  1E2S P;  2IFY A;  3NKM A;  1ELY A;  2W5W A;  3T01 A;  1SHQ A;  3WAX A;  3NKP A;  1KH9 A;  2W8S A;  3DYC A;  3T02 A;  4UOO A;  5IJQ A;  3BDG B;  3BDH A;  1KHN A;  3M8W A;  3IDD A;  3BDG A;  5DLT A;  3NKN A;  1ALJ A;  4KM4 A;  1ED9 A;  5LQQ A;  4LR9 A;  3SZY A;  1ALH A;  1Y6V A;  4LRA A;  3IGZ B;  4NWJ A;  3UNY A;  4TN0 A;  4GTW A;  5DLV A;  1SHN A;  3B5Q A;  4MY4 A;  4FDI A;  5L0E A;  5LIA A;  2W5X A;  1AJD A;  2ZKT A;  2W5T A;  5L0B A;  1ZED A;  1HQA A;  2D1G A;  4LRB A;  3A52 A;  4LRC A;  4UPH A;  4KAY A;  1AUK A;  4ZG9 A;  3TWZ A;  4ZGA A;  1O98 A;  1ELZ A;  3MK0 A;  3WAW A;  3NKR A;  1K7H A;  2W5R A;  4UOP A;  5INH A;  5LRM A;  1ELX A;  4B56 A;  1P49 A;  4LR7 A;  2X98 A;  5L0K A;  1KH7 A;  3WAY A;  3KD8 A;  4ZG7 A;  1E33 P;  5K4P A;  3NKO A;  3WBH A;  1EW8 A;  1ED8 A;  3CMR A;  4GTY A;  2W5S A;  2XR9 A;  5C66 A;  3TG0 A;  1N2K A;  4LR2 A;  1N2L A;  3SZZ A;  5EGE A;  4UPL A;  5LRN A;  4YR1 A;  5HRT A;  1ZEB A;  1ANI A;  3NVL A;  1ZEF A;  3ED4 A;  4MIV A;  1KH4 A;  5KXA A;  4FDJ A;  1E1Z P;  1KHK A;  5DLW A;  3TX0 A;  2RH6 A;  4KAV A;  5TJ3 A;  4CXU A;  4CXK A;  2ANH A;  4GTX A;  4N7T A;  4LQY A;  2VQR A;  1AJA A;  3MK1 A;  5GRR A;  4LRF A;  4CYS A;  2IUC B;  2W8D A;  2W5Q A;  4GTZ A;  3UN2 A;  1URA A;  1KHJ A;  4KJD A;  4CXS A;  5EGH A;  2GSN A;  3UN5 A;  1EI6 A;  1KHL A;  3DPC A;  4ZG6 A;  2GSU A;  4LR8 A; 
#chains in the Genus database with same CATH topology
 1FSU A;  1AJB A;  4UOR A;  3M8Z A;  2GLQ A;  1Y7A A;  3WAV A;  1EQJ A;  2W5V A;  3NKQ A;  2GSO A;  2GA3 A;  3BDF A;  1EW9 A;  1E3C P;  4QAX A;  4MHX A;  1HJK A;  3T00 A;  1HDH A;  1KH5 A;  2QZU A;  3Q3Q A;  1ALK A;  4CYR A;  3IGY B;  4LRE A;  3MK2 A;  4NWX A;  5GOV A;  3M7V A;  3M8Y A;  1B8J A;  1ANJ A;  2IUC A;  4LRD A;  1EJJ A;  5AJ9 A;  1O99 A;  1ALI A;  2XRG A;  3E2D A;  3LXQ A;  3UN3 A;  1EW2 A;  4KJG A;  4UPK A;  3UO0 A;  5IJS A;  1AJC A;  2G9Y A;  3OT9 A;  4UPI A;  1URB A;  1E2S P;  2IFY A;  3NKM A;  1ELY A;  2W5W A;  3T01 A;  1SHQ A;  3WAX A;  3NKP A;  1KH9 A;  2W8S A;  3DYC A;  3T02 A;  4UOO A;  5IJQ A;  3BDG B;  3BDH A;  1KHN A;  3M8W A;  3IDD A;  3BDG A;  5DLT A;  3NKN A;  1ALJ A;  4KM4 A;  1ED9 A;  5LQQ A;  4LR9 A;  3SZY A;  1ALH A;  1Y6V A;  4LRA A;  3IGZ B;  4NWJ A;  3UNY A;  4TN0 A;  4GTW A;  5DLV A;  1SHN A;  3B5Q A;  4MY4 A;  4FDI A;  5L0E A;  5LIA A;  2W5X A;  1AJD A;  2ZKT A;  2W5T A;  5L0B A;  1ZED A;  1HQA A;  2D1G A;  4LRB A;  3A52 A;  4LRC A;  4UPH A;  4KAY A;  1AUK A;  4ZG9 A;  3TWZ A;  4ZGA A;  1O98 A;  1ELZ A;  3MK0 A;  3WAW A;  3NKR A;  1K7H A;  2W5R A;  4UOP A;  5INH A;  5LRM A;  1ELX A;  4B56 A;  1P49 A;  4LR7 A;  2X98 A;  5L0K A;  1KH7 A;  3WAY A;  3KD8 A;  4ZG7 A;  1E33 P;  5K4P A;  3NKO A;  3WBH A;  1EW8 A;  1ED8 A;  3CMR A;  4GTY A;  2W5S A;  2XR9 A;  5C66 A;  3TG0 A;  1N2K A;  4LR2 A;  1N2L A;  3SZZ A;  5EGE A;  4UPL A;  5LRN A;  4YR1 A;  5HRT A;  1ZEB A;  1ANI A;  3NVL A;  1ZEF A;  3ED4 A;  4MIV A;  1KH4 A;  5KXA A;  4FDJ A;  1E1Z P;  1KHK A;  5DLW A;  3TX0 A;  2RH6 A;  4KAV A;  5TJ3 A;  4CXU A;  4CXK A;  2ANH A;  4GTX A;  4N7T A;  4LQY A;  2VQR A;  1AJA A;  3MK1 A;  5GRR A;  4LRF A;  4CYS A;  2IUC B;  2W8D A;  2W5Q A;  4GTZ A;  3UN2 A;  1URA A;  1KHJ A;  4KJD A;  4CXS A;  5EGH A;  2GSN A;  3UN5 A;  1EI6 A;  1KHL A;  3DPC A;  4ZG6 A;  2GSU A;  4LR8 A; 
#chains in the Genus database with same CATH homology
 1FSU A;  1AJB A;  4UOR A;  3M8Z A;  2GLQ A;  1Y7A A;  3WAV A;  1EQJ A;  2W5V A;  3NKQ A;  2GSO A;  2GA3 A;  3BDF A;  1EW9 A;  1E3C P;  4QAX A;  4MHX A;  1HJK A;  3T00 A;  1HDH A;  1KH5 A;  2QZU A;  3Q3Q A;  1ALK A;  4CYR A;  3IGY B;  4LRE A;  3MK2 A;  4NWX A;  5GOV A;  3M7V A;  3M8Y A;  1B8J A;  1ANJ A;  2IUC A;  4LRD A;  1EJJ A;  5AJ9 A;  1O99 A;  1ALI A;  2XRG A;  3E2D A;  3LXQ A;  3UN3 A;  1EW2 A;  4KJG A;  4UPK A;  3UO0 A;  5IJS A;  1AJC A;  2G9Y A;  3OT9 A;  4UPI A;  1URB A;  1E2S P;  2IFY A;  3NKM A;  1ELY A;  2W5W A;  3T01 A;  1SHQ A;  3WAX A;  3NKP A;  1KH9 A;  2W8S A;  3DYC A;  3T02 A;  4UOO A;  5IJQ A;  3BDG B;  3BDH A;  1KHN A;  3M8W A;  3IDD A;  3BDG A;  5DLT A;  3NKN A;  1ALJ A;  4KM4 A;  1ED9 A;  5LQQ A;  4LR9 A;  3SZY A;  1ALH A;  1Y6V A;  4LRA A;  3IGZ B;  4NWJ A;  3UNY A;  4TN0 A;  4GTW A;  5DLV A;  1SHN A;  3B5Q A;  4MY4 A;  4FDI A;  5L0E A;  5LIA A;  2W5X A;  1AJD A;  2ZKT A;  2W5T A;  5L0B A;  1ZED A;  1HQA A;  2D1G A;  4LRB A;  3A52 A;  4LRC A;  4UPH A;  4KAY A;  1AUK A;  4ZG9 A;  3TWZ A;  4ZGA A;  1O98 A;  1ELZ A;  3MK0 A;  3WAW A;  3NKR A;  1K7H A;  2W5R A;  4UOP A;  5INH A;  5LRM A;  1ELX A;  4B56 A;  1P49 A;  4LR7 A;  2X98 A;  5L0K A;  1KH7 A;  3WAY A;  3KD8 A;  4ZG7 A;  1E33 P;  5K4P A;  3NKO A;  3WBH A;  1EW8 A;  1ED8 A;  3CMR A;  4GTY A;  2W5S A;  2XR9 A;  5C66 A;  3TG0 A;  1N2K A;  4LR2 A;  1N2L A;  3SZZ A;  5EGE A;  4UPL A;  5LRN A;  4YR1 A;  5HRT A;  1ZEB A;  1ANI A;  3NVL A;  1ZEF A;  3ED4 A;  4MIV A;  1KH4 A;  5KXA A;  4FDJ A;  1E1Z P;  1KHK A;  5DLW A;  3TX0 A;  2RH6 A;  4KAV A;  5TJ3 A;  4CXU A;  4CXK A;  2ANH A;  4GTX A;  4N7T A;  4LQY A;  2VQR A;  1AJA A;  3MK1 A;  5GRR A;  4LRF A;  4CYS A;  2IUC B;  2W8D A;  2W5Q A;  4GTZ A;  3UN2 A;  1URA A;  1KHJ A;  4KJD A;  4CXS A;  5EGH A;  2GSN A;  3UN5 A;  1EI6 A;  1KHL A;  3DPC A;  4ZG6 A;  2GSU A;  4LR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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