1KH7 | Genus

Total Genus 151

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	151
Knots found	KnotProt 2.0: S +3₁
sequence length	444
structure length	444
Chain Sequence	VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Escherichia coli
publication title	Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. pubmed doi rcsb
molecule keywords	alkaline phosphatase
total genus	151
structure length	444
sequence length	444
chains with identical sequence	B
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2001-11-29

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1kh7A00

4UORA 4KM4A 1EJJA 2RH6A 5DLWA 3BDGA 1E33P 5K4PA 5EGHA 4UPKA 4LQYA 4NWXA 3NKMA 5KXAA 3WBHA 3M7VA 3T01A 4UPIA 1ALKA 2GSUA 2IFYA 3UNYA 4KJGA 2GSOA 2GA3A 3UN5A 4ZG6A 3DYCA 5DLVA 1URBA 1ELXA 3TX0A 5LIAA 1KHJA 5HRTA 2X98A 3NKNA 4NWJA 1ANIA 4UOOA 4LRCA 1URAA 5DLTA 1E3CP 4FDIA 4UPLA 4CYSA 1ELYA 3Q3QA 3M8ZA 3IDDA 3E2DA 4CXKA 3BDGB 1KHNA 5LRNA 2ANHA 4LR9A 2GSNA 4MHXA 4CXSA 4TN0A 1EI6A 3WAXA 2XRGA 1EW2A 1AJAA 3ED4A 5GOVA 3T00A 4YR1A 3UO0A 3TWZA 1KHLA 4CXUA 3DPCA 5IJSA 1ELZA 1SHNA 5EGEA 3IGZB 1ZEDA 2QZUA 1ZEBA 4LRFA 5AJ9A 1HDHA 1AJDA 3NKRA 1EW8A 4GTZA 2GLQA 2W5XA 1B8JA 4ZG9A 5INHA 3BDFA 3WAVA 2W5WA 1AJCA 1SHQA 3UN2A 1O98A 3NVLA 1ALJA 4LREA 2W5QA 1Y7AA 1Y6VA 3MK0A 1P49A 1ZEFA 3TG0A 2W5SA 1E2SP 1ALHA 1N2KA 3MK2A 3CMRA 5L0BA 1EQJA 3MK1A 4ZGAA 5LRMA 3M8WA 4LR2A 3NKOA 3UN3A 1AUKA 1FSUA 4QAXA 2W8DA 4LR8A 1O99A 2W8SA 3B5QA 5LQQA 4CYRA 1N2LA 1ED8A 4LRBA 3WAYA 3WAWA 2IUCB 1KH9A 4GTXA 2IUCA 3SZYA 1ALIA 3SZZA 4LRDA 3NKQA 3A52A 4B56A 4GTWA 1ANJA 1AJBA 1KH5A 3LXQA 2ZKTA 2W5VA 5IJQA 4KAYA 2W5RA 4UPHA 1ED9A 3T02A 1KHKA 5C66A 5L0KA 4KJDA 5L0EA 2VQRA 1E1ZP 2XR9A 3IGYB 3NKPA 4KAVA 4LR7A 4GTYA 4FDJA 1HQAA 2W5TA 3BDHA 5TJ3A 1KH7A 1K7HA 4MY4A 4UOPA 1HJKA 5GRRA 3M8YA 4MIVA 1KH4A 2G9YA 3KD8A 3OT9A 4N7TA 4LRAA 4ZG7A 2D1GA 1EW9A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 4UOR A;  4KM4 A;  1EJJ A;  2RH6 A;  5DLW A;  3BDG A;  1E33 P;  5K4P A;  5EGH A;  4UPK A;  4LQY A;  4NWX A;  3NKM A;  5KXA A;  3WBH A;  3M7V A;  3T01 A;  4UPI A;  1ALK A;  2GSU A;  2IFY A;  3UNY A;  4KJG A;  2GSO A;  2GA3 A;  3UN5 A;  4ZG6 A;  3DYC A;  5DLV A;  1URB A;  1ELX A;  3TX0 A;  5LIA A;  1KHJ A;  5HRT A;  2X98 A;  3NKN A;  4NWJ A;  1ANI A;  4UOO A;  4LRC A;  1URA A;  5DLT A;  1E3C P;  4FDI A;  4UPL A;  4CYS A;  1ELY A;  3Q3Q A;  3M8Z A;  3IDD A;  3E2D A;  4CXK A;  3BDG B;  1KHN A;  5LRN A;  2ANH A;  4LR9 A;  2GSN A;  4MHX A;  4CXS A;  4TN0 A;  1EI6 A;  3WAX A;  2XRG A;  1EW2 A;  1AJA A;  3ED4 A;  5GOV A;  3T00 A;  4YR1 A;  3UO0 A;  3TWZ A;  1KHL A;  4CXU A;  3DPC A;  5IJS A;  1ELZ A;  1SHN A;  5EGE A;  3IGZ B;  1ZED A;  2QZU A;  1ZEB A;  4LRF A;  5AJ9 A;  1HDH A;  1AJD A;  3NKR A;  1EW8 A;  4GTZ A;  2GLQ A;  2W5X A;  1B8J A;  4ZG9 A;  5INH A;  3BDF A;  3WAV A;  2W5W A;  1AJC A;  1SHQ A;  3UN2 A;  1O98 A;  3NVL A;  1ALJ A;  4LRE A;  2W5Q A;  1Y7A A;  1Y6V A;  3MK0 A;  1P49 A;  1ZEF A;  3TG0 A;  2W5S A;  1E2S P;  1ALH A;  1N2K A;  3MK2 A;  3CMR A;  5L0B A;  1EQJ A;  3MK1 A;  4ZGA A;  5LRM A;  3M8W A;  4LR2 A;  3NKO A;  3UN3 A;  1AUK A;  1FSU A;  4QAX A;  2W8D A;  4LR8 A;  1O99 A;  2W8S A;  3B5Q A;  5LQQ A;  4CYR A;  1N2L A;  1ED8 A;  4LRB A;  3WAY A;  3WAW A;  2IUC B;  1KH9 A;  4GTX A;  2IUC A;  3SZY A;  1ALI A;  3SZZ A;  4LRD A;  3NKQ A;  3A52 A;  4B56 A;  4GTW A;  1ANJ A;  1AJB A;  1KH5 A;  3LXQ A;  2ZKT A;  2W5V A;  5IJQ A;  4KAY A;  2W5R A;  4UPH A;  1ED9 A;  3T02 A;  1KHK A;  5C66 A;  5L0K A;  4KJD A;  5L0E A;  2VQR A;  1E1Z P;  2XR9 A;  3IGY B;  3NKP A;  4KAV A;  4LR7 A;  4GTY A;  4FDJ A;  1HQA A;  2W5T A;  3BDH A;  5TJ3 A;  1KH7 A;  1K7H A;  4MY4 A;  4UOP A;  1HJK A;  5GRR A;  3M8Y A;  4MIV A;  1KH4 A;  2G9Y A;  3KD8 A;  3OT9 A;  4N7T A;  4LRA A;  4ZG7 A;  2D1G A;  1EW9 A; 
#chains in the Genus database with same CATH topology
 4UOR A;  4KM4 A;  1EJJ A;  2RH6 A;  5DLW A;  3BDG A;  1E33 P;  5K4P A;  5EGH A;  4UPK A;  4LQY A;  4NWX A;  3NKM A;  5KXA A;  3WBH A;  3M7V A;  3T01 A;  4UPI A;  1ALK A;  2GSU A;  2IFY A;  3UNY A;  4KJG A;  2GSO A;  2GA3 A;  3UN5 A;  4ZG6 A;  3DYC A;  5DLV A;  1URB A;  1ELX A;  3TX0 A;  5LIA A;  1KHJ A;  5HRT A;  2X98 A;  3NKN A;  4NWJ A;  1ANI A;  4UOO A;  4LRC A;  1URA A;  5DLT A;  1E3C P;  4FDI A;  4UPL A;  4CYS A;  1ELY A;  3Q3Q A;  3M8Z A;  3IDD A;  3E2D A;  4CXK A;  3BDG B;  1KHN A;  5LRN A;  2ANH A;  4LR9 A;  2GSN A;  4MHX A;  4CXS A;  4TN0 A;  1EI6 A;  3WAX A;  2XRG A;  1EW2 A;  1AJA A;  3ED4 A;  5GOV A;  3T00 A;  4YR1 A;  3UO0 A;  3TWZ A;  1KHL A;  4CXU A;  3DPC A;  5IJS A;  1ELZ A;  1SHN A;  5EGE A;  3IGZ B;  1ZED A;  2QZU A;  1ZEB A;  4LRF A;  5AJ9 A;  1HDH A;  1AJD A;  3NKR A;  1EW8 A;  4GTZ A;  2GLQ A;  2W5X A;  1B8J A;  4ZG9 A;  5INH A;  3BDF A;  3WAV A;  2W5W A;  1AJC A;  1SHQ A;  3UN2 A;  1O98 A;  3NVL A;  1ALJ A;  4LRE A;  2W5Q A;  1Y7A A;  1Y6V A;  3MK0 A;  1P49 A;  1ZEF A;  3TG0 A;  2W5S A;  1E2S P;  1ALH A;  1N2K A;  3MK2 A;  3CMR A;  5L0B A;  1EQJ A;  3MK1 A;  4ZGA A;  5LRM A;  3M8W A;  4LR2 A;  3NKO A;  3UN3 A;  1AUK A;  1FSU A;  4QAX A;  2W8D A;  4LR8 A;  1O99 A;  2W8S A;  3B5Q A;  5LQQ A;  4CYR A;  1N2L A;  1ED8 A;  4LRB A;  3WAY A;  3WAW A;  2IUC B;  1KH9 A;  4GTX A;  2IUC A;  3SZY A;  1ALI A;  3SZZ A;  4LRD A;  3NKQ A;  3A52 A;  4B56 A;  4GTW A;  1ANJ A;  1AJB A;  1KH5 A;  3LXQ A;  2ZKT A;  2W5V A;  5IJQ A;  4KAY A;  2W5R A;  4UPH A;  1ED9 A;  3T02 A;  1KHK A;  5C66 A;  5L0K A;  4KJD A;  5L0E A;  2VQR A;  1E1Z P;  2XR9 A;  3IGY B;  3NKP A;  4KAV A;  4LR7 A;  4GTY A;  4FDJ A;  1HQA A;  2W5T A;  3BDH A;  5TJ3 A;  1KH7 A;  1K7H A;  4MY4 A;  4UOP A;  1HJK A;  5GRR A;  3M8Y A;  4MIV A;  1KH4 A;  2G9Y A;  3KD8 A;  3OT9 A;  4N7T A;  4LRA A;  4ZG7 A;  2D1G A;  1EW9 A; 
#chains in the Genus database with same CATH homology
 4UOR A;  4KM4 A;  1EJJ A;  2RH6 A;  5DLW A;  3BDG A;  1E33 P;  5K4P A;  5EGH A;  4UPK A;  4LQY A;  4NWX A;  3NKM A;  5KXA A;  3WBH A;  3M7V A;  3T01 A;  4UPI A;  1ALK A;  2GSU A;  2IFY A;  3UNY A;  4KJG A;  2GSO A;  2GA3 A;  3UN5 A;  4ZG6 A;  3DYC A;  5DLV A;  1URB A;  1ELX A;  3TX0 A;  5LIA A;  1KHJ A;  5HRT A;  2X98 A;  3NKN A;  4NWJ A;  1ANI A;  4UOO A;  4LRC A;  1URA A;  5DLT A;  1E3C P;  4FDI A;  4UPL A;  4CYS A;  1ELY A;  3Q3Q A;  3M8Z A;  3IDD A;  3E2D A;  4CXK A;  3BDG B;  1KHN A;  5LRN A;  2ANH A;  4LR9 A;  2GSN A;  4MHX A;  4CXS A;  4TN0 A;  1EI6 A;  3WAX A;  2XRG A;  1EW2 A;  1AJA A;  3ED4 A;  5GOV A;  3T00 A;  4YR1 A;  3UO0 A;  3TWZ A;  1KHL A;  4CXU A;  3DPC A;  5IJS A;  1ELZ A;  1SHN A;  5EGE A;  3IGZ B;  1ZED A;  2QZU A;  1ZEB A;  4LRF A;  5AJ9 A;  1HDH A;  1AJD A;  3NKR A;  1EW8 A;  4GTZ A;  2GLQ A;  2W5X A;  1B8J A;  4ZG9 A;  5INH A;  3BDF A;  3WAV A;  2W5W A;  1AJC A;  1SHQ A;  3UN2 A;  1O98 A;  3NVL A;  1ALJ A;  4LRE A;  2W5Q A;  1Y7A A;  1Y6V A;  3MK0 A;  1P49 A;  1ZEF A;  3TG0 A;  2W5S A;  1E2S P;  1ALH A;  1N2K A;  3MK2 A;  3CMR A;  5L0B A;  1EQJ A;  3MK1 A;  4ZGA A;  5LRM A;  3M8W A;  4LR2 A;  3NKO A;  3UN3 A;  1AUK A;  1FSU A;  4QAX A;  2W8D A;  4LR8 A;  1O99 A;  2W8S A;  3B5Q A;  5LQQ A;  4CYR A;  1N2L A;  1ED8 A;  4LRB A;  3WAY A;  3WAW A;  2IUC B;  1KH9 A;  4GTX A;  2IUC A;  3SZY A;  1ALI A;  3SZZ A;  4LRD A;  3NKQ A;  3A52 A;  4B56 A;  4GTW A;  1ANJ A;  1AJB A;  1KH5 A;  3LXQ A;  2ZKT A;  2W5V A;  5IJQ A;  4KAY A;  2W5R A;  4UPH A;  1ED9 A;  3T02 A;  1KHK A;  5C66 A;  5L0K A;  4KJD A;  5L0E A;  2VQR A;  1E1Z P;  2XR9 A;  3IGY B;  3NKP A;  4KAV A;  4LR7 A;  4GTY A;  4FDJ A;  1HQA A;  2W5T A;  3BDH A;  5TJ3 A;  1KH7 A;  1K7H A;  4MY4 A;  4UOP A;  1HJK A;  5GRR A;  3M8Y A;  4MIV A;  1KH4 A;  2G9Y A;  3KD8 A;  3OT9 A;  4N7T A;  4LRA A;  4ZG7 A;  2D1G A;  1EW9 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1KH7A

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations