1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
5HRTA 1K7HA 1ZEDA 2D1GA 4KJGA 3MK1A 4KJDA 3TG0A 3IGYB 2GLQA 3Q3QA 4MHXA 3ED4A 1KHKA 4LR7A 4LR9A 4CXSA 1SHQA 3LXQA 1EI6A 4ZGAA 3M8WA 3T00A 3UNYA 1EW8A 1O98A 3TX0A 2W8SA 4QAXA 4LRAA 2IFYA 2W5QA 4FDJA 3A52A 3M8YA 5L0BA 3NKQA 5LQQA 2RH6A 2VQRA 5GRRA 4ZG6A 3IDDA 1ANIA 3BDGB 2XRGA 4GTYA 3BDGA 3WAYA 3WBHA 1Y6VA 5KXAA 1ELYA 2W5VA 4TN0A 4FDIA 5TJ3A 3UN5A 4UPIA 3WAXA 1ANJA 4NWJA 4GTZA 1N2KA 4UPHA 4LR8A 3DPCA 3IGZB 1ED9A 1KH5A 2GSNA 4CXUA 1EW2A 3WAWA 4B56A 1Y7AA 1KH9A 1HDHA 5LRMA 3M7VA 1EJJA 4KM4A 4LR2A 1ZEBA 4CYSA 1KH4A 1HQAA 1AJAA 1N2LA 4UORA 3SZZA 3NKPA 1ALIA 4LQYA 4LRCA 4YR1A 1P49A 3MK2A 1ELZA 3BDFA 4LREA 4LRFA 1B8JA 2ANHA 1AJBA 3B5QA 2W8DA 4GTXA 2W5RA 4GTWA 3UO0A 1KHLA 2GSUA 1ELXA 4UOPA 1AJCA 5LIAA 4ZG7A 4N7TA 1E3CP 3BDHA 3M8ZA 1URBA 1EW9A 5INHA 5IJSA 2GA3A 2X98A 3NKMA 1ALHA 5EGHA 3NKNA 4CYRA 3DYCA 3E2DA 3T02A 1O99A 3NKOA 2W5WA 5AJ9A 1EQJA 1ED8A 1FSUA 2W5SA 5K4PA 3T01A 5L0KA 4UOOA 2GSOA 1URAA 3CMRA 4NWXA 4CXKA 3NKRA 1KHNA 5LRNA 1E2SP 1ALKA 3UN3A 3SZYA 4LRBA 2QZUA 4UPKA 1AUKA 4MIVA 5L0EA 5IJQA 3OT9A 1AJDA 1HJKA 1SHNA 3UN2A 4KAVA 4ZG9A 2XR9A 3WAVA 2IUCB 2W5XA 3KD8A 2W5TA 2IUCA 5DLTA 5C66A 1KH7A 3NVLA 1KHJA 5DLWA 4UPLA 1E33P 5EGEA 5DLVA 1ALJA 4KAYA 5GOVA 1ZEFA 4LRDA 3TWZA 3MK0A 2G9YA 2ZKTA 1E1ZP 4MY4A
chains in the Genus database with same CATH superfamily
5HRTA 1K7HA 1ZEDA 2D1GA 4KJGA 3MK1A 4KJDA 3TG0A 3IGYB 2GLQA 3Q3QA 4MHXA 3ED4A 1KHKA 4LR7A 4LR9A 4CXSA 1SHQA 3LXQA 1EI6A 4ZGAA 3M8WA 3T00A 3UNYA 1EW8A 1O98A 3TX0A 2W8SA 4QAXA 4LRAA 2IFYA 2W5QA 4FDJA 3A52A 3M8YA 5L0BA 3NKQA 5LQQA 2RH6A 2VQRA 5GRRA 4ZG6A 3IDDA 1ANIA 3BDGB 2XRGA 4GTYA 3BDGA 3WAYA 3WBHA 1Y6VA 5KXAA 1ELYA 2W5VA 4TN0A 4FDIA 5TJ3A 3UN5A 4UPIA 3WAXA 1ANJA 4NWJA 4GTZA 1N2KA 4UPHA 4LR8A 3DPCA 3IGZB 1ED9A 1KH5A 2GSNA 4CXUA 1EW2A 3WAWA 4B56A 1Y7AA 1KH9A 1HDHA 5LRMA 3M7VA 1EJJA 4KM4A 4LR2A 1ZEBA 4CYSA 1KH4A 1HQAA 1AJAA 1N2LA 4UORA 3SZZA 3NKPA 1ALIA 4LQYA 4LRCA 4YR1A 1P49A 3MK2A 1ELZA 3BDFA 4LREA 4LRFA 1B8JA 2ANHA 1AJBA 3B5QA 2W8DA 4GTXA 2W5RA 4GTWA 3UO0A 1KHLA 2GSUA 1ELXA 4UOPA 1AJCA 5LIAA 4ZG7A 4N7TA 1E3CP 3BDHA 3M8ZA 1URBA 1EW9A 5INHA 5IJSA 2GA3A 2X98A 3NKMA 1ALHA 5EGHA 3NKNA 4CYRA 3DYCA 3E2DA 3T02A 1O99A 3NKOA 2W5WA 5AJ9A 1EQJA 1ED8A 1FSUA 2W5SA 5K4PA 3T01A 5L0KA 4UOOA 2GSOA 1URAA 3CMRA 4NWXA 4CXKA 3NKRA 1KHNA 5LRNA 1E2SP 1ALKA 3UN3A 3SZYA 4LRBA 2QZUA 4UPKA 1AUKA 4MIVA 5L0EA 5IJQA 3OT9A 1AJDA 1HJKA 1SHNA 3UN2A 4KAVA 4ZG9A 2XR9A 3WAVA 2IUCB 2W5XA 3KD8A 2W5TA 2IUCA 5DLTA 5C66A 1KH7A 3NVLA 1KHJA 5DLWA 4UPLA 1E33P 5EGEA 5DLVA 1ALJA 4KAYA 5GOVA 1ZEFA 4LRDA 3TWZA 3MK0A 2G9YA 2ZKTA 1E1ZP 4MY4A
chains in the Genus database with same CATH topology
5HRTA 1K7HA 1ZEDA 2D1GA 4KJGA 3MK1A 4KJDA 3TG0A 3IGYB 2GLQA 3Q3QA 4MHXA 3ED4A 1KHKA 4LR7A 4LR9A 4CXSA 1SHQA 3LXQA 1EI6A 4ZGAA 3M8WA 3T00A 3UNYA 1EW8A 1O98A 3TX0A 2W8SA 4QAXA 4LRAA 2IFYA 2W5QA 4FDJA 3A52A 3M8YA 5L0BA 3NKQA 5LQQA 2RH6A 2VQRA 5GRRA 4ZG6A 3IDDA 1ANIA 3BDGB 2XRGA 4GTYA 3BDGA 3WAYA 3WBHA 1Y6VA 5KXAA 1ELYA 2W5VA 4TN0A 4FDIA 5TJ3A 3UN5A 4UPIA 3WAXA 1ANJA 4NWJA 4GTZA 1N2KA 4UPHA 4LR8A 3DPCA 3IGZB 1ED9A 1KH5A 2GSNA 4CXUA 1EW2A 3WAWA 4B56A 1Y7AA 1KH9A 1HDHA 5LRMA 3M7VA 1EJJA 4KM4A 4LR2A 1ZEBA 4CYSA 1KH4A 1HQAA 1AJAA 1N2LA 4UORA 3SZZA 3NKPA 1ALIA 4LQYA 4LRCA 4YR1A 1P49A 3MK2A 1ELZA 3BDFA 4LREA 4LRFA 1B8JA 2ANHA 1AJBA 3B5QA 2W8DA 4GTXA 2W5RA 4GTWA 3UO0A 1KHLA 2GSUA 1ELXA 4UOPA 1AJCA 5LIAA 4ZG7A 4N7TA 1E3CP 3BDHA 3M8ZA 1URBA 1EW9A 5INHA 5IJSA 2GA3A 2X98A 3NKMA 1ALHA 5EGHA 3NKNA 4CYRA 3DYCA 3E2DA 3T02A 1O99A 3NKOA 2W5WA 5AJ9A 1EQJA 1ED8A 1FSUA 2W5SA 5K4PA 3T01A 5L0KA 4UOOA 2GSOA 1URAA 3CMRA 4NWXA 4CXKA 3NKRA 1KHNA 5LRNA 1E2SP 1ALKA 3UN3A 3SZYA 4LRBA 2QZUA 4UPKA 1AUKA 4MIVA 5L0EA 5IJQA 3OT9A 1AJDA 1HJKA 1SHNA 3UN2A 4KAVA 4ZG9A 2XR9A 3WAVA 2IUCB 2W5XA 3KD8A 2W5TA 2IUCA 5DLTA 5C66A 1KH7A 3NVLA 1KHJA 5DLWA 4UPLA 1E33P 5EGEA 5DLVA 1ALJA 4KAYA 5GOVA 1ZEFA 4LRDA 3TWZA 3MK0A 2G9YA 2ZKTA 1E1ZP 4MY4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HRT A;  1K7H A;  1ZED A;  2D1G A;  4KJG A;  3MK1 A;  4KJD A;  3TG0 A;  3IGY B;  2GLQ A;  3Q3Q A;  4MHX A;  3ED4 A;  1KHK A;  4LR7 A;  4LR9 A;  4CXS A;  1SHQ A;  3LXQ A;  1EI6 A;  4ZGA A;  3M8W A;  3T00 A;  3UNY A;  1EW8 A;  1O98 A;  3TX0 A;  2W8S A;  4QAX A;  4LRA A;  2IFY A;  2W5Q A;  4FDJ A;  3A52 A;  3M8Y A;  5L0B A;  3NKQ A;  5LQQ A;  2RH6 A;  2VQR A;  5GRR A;  4ZG6 A;  3IDD A;  1ANI A;  3BDG B;  2XRG A;  4GTY A;  3BDG A;  3WAY A;  3WBH A;  1Y6V A;  5KXA A;  1ELY A;  2W5V A;  4TN0 A;  4FDI A;  5TJ3 A;  3UN5 A;  4UPI A;  3WAX A;  1ANJ A;  4NWJ A;  4GTZ A;  1N2K A;  4UPH A;  4LR8 A;  3DPC A;  3IGZ B;  1ED9 A;  1KH5 A;  2GSN A;  4CXU A;  1EW2 A;  3WAW A;  4B56 A;  1Y7A A;  1KH9 A;  1HDH A;  5LRM A;  3M7V A;  1EJJ A;  4KM4 A;  4LR2 A;  1ZEB A;  4CYS A;  1KH4 A;  1HQA A;  1AJA A;  1N2L A;  4UOR A;  3SZZ A;  3NKP A;  1ALI A;  4LQY A;  4LRC A;  4YR1 A;  1P49 A;  3MK2 A;  1ELZ A;  3BDF A;  4LRE A;  4LRF A;  1B8J A;  2ANH A;  1AJB A;  3B5Q A;  2W8D A;  4GTX A;  2W5R A;  4GTW A;  3UO0 A;  1KHL A;  2GSU A;  1ELX A;  4UOP A;  1AJC A;  5LIA A;  4ZG7 A;  4N7T A;  1E3C P;  3BDH A;  3M8Z A;  1URB A;  1EW9 A;  5INH A;  5IJS A;  2GA3 A;  2X98 A;  3NKM A;  1ALH A;  5EGH A;  3NKN A;  4CYR A;  3DYC A;  3E2D A;  3T02 A;  1O99 A;  3NKO A;  2W5W A;  5AJ9 A;  1EQJ A;  1ED8 A;  1FSU A;  2W5S A;  5K4P A;  3T01 A;  5L0K A;  4UOO A;  2GSO A;  1URA A;  3CMR A;  4NWX A;  4CXK A;  3NKR A;  1KHN A;  5LRN A;  1E2S P;  1ALK A;  3UN3 A;  3SZY A;  4LRB A;  2QZU A;  4UPK A;  1AUK A;  4MIV A;  5L0E A;  5IJQ A;  3OT9 A;  1AJD A;  1HJK A;  1SHN A;  3UN2 A;  4KAV A;  4ZG9 A;  2XR9 A;  3WAV A;  2IUC B;  2W5X A;  3KD8 A;  2W5T A;  2IUC A;  5DLT A;  5C66 A;  1KH7 A;  3NVL A;  1KHJ A;  5DLW A;  4UPL A;  1E33 P;  5EGE A;  5DLV A;  1ALJ A;  4KAY A;  5GOV A;  1ZEF A;  4LRD A;  3TWZ A;  3MK0 A;  2G9Y A;  2ZKT A;  1E1Z P;  4MY4 A; 
#chains in the Genus database with same CATH topology
 5HRT A;  1K7H A;  1ZED A;  2D1G A;  4KJG A;  3MK1 A;  4KJD A;  3TG0 A;  3IGY B;  2GLQ A;  3Q3Q A;  4MHX A;  3ED4 A;  1KHK A;  4LR7 A;  4LR9 A;  4CXS A;  1SHQ A;  3LXQ A;  1EI6 A;  4ZGA A;  3M8W A;  3T00 A;  3UNY A;  1EW8 A;  1O98 A;  3TX0 A;  2W8S A;  4QAX A;  4LRA A;  2IFY A;  2W5Q A;  4FDJ A;  3A52 A;  3M8Y A;  5L0B A;  3NKQ A;  5LQQ A;  2RH6 A;  2VQR A;  5GRR A;  4ZG6 A;  3IDD A;  1ANI A;  3BDG B;  2XRG A;  4GTY A;  3BDG A;  3WAY A;  3WBH A;  1Y6V A;  5KXA A;  1ELY A;  2W5V A;  4TN0 A;  4FDI A;  5TJ3 A;  3UN5 A;  4UPI A;  3WAX A;  1ANJ A;  4NWJ A;  4GTZ A;  1N2K A;  4UPH A;  4LR8 A;  3DPC A;  3IGZ B;  1ED9 A;  1KH5 A;  2GSN A;  4CXU A;  1EW2 A;  3WAW A;  4B56 A;  1Y7A A;  1KH9 A;  1HDH A;  5LRM A;  3M7V A;  1EJJ A;  4KM4 A;  4LR2 A;  1ZEB A;  4CYS A;  1KH4 A;  1HQA A;  1AJA A;  1N2L A;  4UOR A;  3SZZ A;  3NKP A;  1ALI A;  4LQY A;  4LRC A;  4YR1 A;  1P49 A;  3MK2 A;  1ELZ A;  3BDF A;  4LRE A;  4LRF A;  1B8J A;  2ANH A;  1AJB A;  3B5Q A;  2W8D A;  4GTX A;  2W5R A;  4GTW A;  3UO0 A;  1KHL A;  2GSU A;  1ELX A;  4UOP A;  1AJC A;  5LIA A;  4ZG7 A;  4N7T A;  1E3C P;  3BDH A;  3M8Z A;  1URB A;  1EW9 A;  5INH A;  5IJS A;  2GA3 A;  2X98 A;  3NKM A;  1ALH A;  5EGH A;  3NKN A;  4CYR A;  3DYC A;  3E2D A;  3T02 A;  1O99 A;  3NKO A;  2W5W A;  5AJ9 A;  1EQJ A;  1ED8 A;  1FSU A;  2W5S A;  5K4P A;  3T01 A;  5L0K A;  4UOO A;  2GSO A;  1URA A;  3CMR A;  4NWX A;  4CXK A;  3NKR A;  1KHN A;  5LRN A;  1E2S P;  1ALK A;  3UN3 A;  3SZY A;  4LRB A;  2QZU A;  4UPK A;  1AUK A;  4MIV A;  5L0E A;  5IJQ A;  3OT9 A;  1AJD A;  1HJK A;  1SHN A;  3UN2 A;  4KAV A;  4ZG9 A;  2XR9 A;  3WAV A;  2IUC B;  2W5X A;  3KD8 A;  2W5T A;  2IUC A;  5DLT A;  5C66 A;  1KH7 A;  3NVL A;  1KHJ A;  5DLW A;  4UPL A;  1E33 P;  5EGE A;  5DLV A;  1ALJ A;  4KAY A;  5GOV A;  1ZEF A;  4LRD A;  3TWZ A;  3MK0 A;  2G9Y A;  2ZKT A;  1E1Z P;  4MY4 A; 
#chains in the Genus database with same CATH homology
 5HRT A;  1K7H A;  1ZED A;  2D1G A;  4KJG A;  3MK1 A;  4KJD A;  3TG0 A;  3IGY B;  2GLQ A;  3Q3Q A;  4MHX A;  3ED4 A;  1KHK A;  4LR7 A;  4LR9 A;  4CXS A;  1SHQ A;  3LXQ A;  1EI6 A;  4ZGA A;  3M8W A;  3T00 A;  3UNY A;  1EW8 A;  1O98 A;  3TX0 A;  2W8S A;  4QAX A;  4LRA A;  2IFY A;  2W5Q A;  4FDJ A;  3A52 A;  3M8Y A;  5L0B A;  3NKQ A;  5LQQ A;  2RH6 A;  2VQR A;  5GRR A;  4ZG6 A;  3IDD A;  1ANI A;  3BDG B;  2XRG A;  4GTY A;  3BDG A;  3WAY A;  3WBH A;  1Y6V A;  5KXA A;  1ELY A;  2W5V A;  4TN0 A;  4FDI A;  5TJ3 A;  3UN5 A;  4UPI A;  3WAX A;  1ANJ A;  4NWJ A;  4GTZ A;  1N2K A;  4UPH A;  4LR8 A;  3DPC A;  3IGZ B;  1ED9 A;  1KH5 A;  2GSN A;  4CXU A;  1EW2 A;  3WAW A;  4B56 A;  1Y7A A;  1KH9 A;  1HDH A;  5LRM A;  3M7V A;  1EJJ A;  4KM4 A;  4LR2 A;  1ZEB A;  4CYS A;  1KH4 A;  1HQA A;  1AJA A;  1N2L A;  4UOR A;  3SZZ A;  3NKP A;  1ALI A;  4LQY A;  4LRC A;  4YR1 A;  1P49 A;  3MK2 A;  1ELZ A;  3BDF A;  4LRE A;  4LRF A;  1B8J A;  2ANH A;  1AJB A;  3B5Q A;  2W8D A;  4GTX A;  2W5R A;  4GTW A;  3UO0 A;  1KHL A;  2GSU A;  1ELX A;  4UOP A;  1AJC A;  5LIA A;  4ZG7 A;  4N7T A;  1E3C P;  3BDH A;  3M8Z A;  1URB A;  1EW9 A;  5INH A;  5IJS A;  2GA3 A;  2X98 A;  3NKM A;  1ALH A;  5EGH A;  3NKN A;  4CYR A;  3DYC A;  3E2D A;  3T02 A;  1O99 A;  3NKO A;  2W5W A;  5AJ9 A;  1EQJ A;  1ED8 A;  1FSU A;  2W5S A;  5K4P A;  3T01 A;  5L0K A;  4UOO A;  2GSO A;  1URA A;  3CMR A;  4NWX A;  4CXK A;  3NKR A;  1KHN A;  5LRN A;  1E2S P;  1ALK A;  3UN3 A;  3SZY A;  4LRB A;  2QZU A;  4UPK A;  1AUK A;  4MIV A;  5L0E A;  5IJQ A;  3OT9 A;  1AJD A;  1HJK A;  1SHN A;  3UN2 A;  4KAV A;  4ZG9 A;  2XR9 A;  3WAV A;  2IUC B;  2W5X A;  3KD8 A;  2W5T A;  2IUC A;  5DLT A;  5C66 A;  1KH7 A;  3NVL A;  1KHJ A;  5DLW A;  4UPL A;  1E33 P;  5EGE A;  5DLV A;  1ALJ A;  4KAY A;  5GOV A;  1ZEF A;  4LRD A;  3TWZ A;  3MK0 A;  2G9Y A;  2ZKT A;  1E1Z P;  4MY4 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...