1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
1KHJA 5L0BA 1KH7A 3T00A 4UPHA 3UO0A 1E33P 1E1ZP 1ZEDA 2G9YA 3LXQA 5K4PA 3TWZA 3BDGA 4LR2A 2VQRA 5LRMA 2D1GA 3MK2A 4LRCA 5EGHA 3IGYB 5GRRA 3WAYA 1KH9A 5TJ3A 4FDJA 4B56A 4GTWA 2W5XA 4LRBA 1HDHA 4MIVA 4CXSA 4NWXA 4LQYA 1KH5A 2GSOA 2ANHA 4ZGAA 2ZKTA 4LREA 3NKOA 4CXKA 3UN3A 4KJDA 3OT9A 2IFYA 3BDHA 1SHNA 3WAXA 4UPIA 4KM4A 5AJ9A 1ED9A 2X98A 5EGEA 3UN2A 1ANIA 1Y6VA 3M8YA 4FDIA 4LRFA 3NKQA 5DLTA 4YR1A 4LRAA 3WAWA 4CXUA 3NVLA 4UPKA 1EJJA 3A52A 2IUCB 3SZZA 1EI6A 2W5QA 5LRNA 1ELYA 5IJSA 1KHLA 1ELZA 1ALIA 3B5QA 1AJBA 5IJQA 1ALHA 1EW9A 2IUCA 2XRGA 1K7HA 3IGZB 3Q3QA 4ZG7A 3M8WA 3BDGB 2W5VA 1EW8A 1E2SP 3BDFA 4QAXA 5L0EA 2W5TA 2W8SA 3WAVA 2GSUA 2GLQA 2RH6A 3NKNA 4TN0A 2GSNA 4LR8A 4ZG6A 4UOOA 1URBA 2XR9A 3CMRA 2W5RA 5DLWA 3T01A 3NKMA 5LIAA 3M7VA 3TX0A 2W5SA 1Y7AA 2W5WA 1ALJA 1N2KA 4KAVA 1KH4A 3ED4A 3UNYA 4UPLA 4KJGA 5KXAA 4GTYA 5GOVA 1AJDA 1B8JA 4NWJA 3SZYA 4MHXA 3MK1A 4LR9A 5LQQA 4LRDA 4MY4A 3WBHA 3E2DA 2GA3A 4CYSA 1P49A 1O98A 1ANJA 3DYCA 1FSUA 3M8ZA 4CYRA 4ZG9A 3DPCA 1ZEFA 1HQAA 4GTZA 4GTXA 3KD8A 1N2LA 3T02A 3MK0A 1AJCA 5INHA 1AUKA 4N7TA 1AJAA 2QZUA 3TG0A 1EQJA 1SHQA 1KHKA 4LR7A 2W8DA 5DLVA 4UOPA 1EW2A 3IDDA 1KHNA 1ELXA 4KAYA 1ALKA 1ED8A 1E3CP 3NKRA 1HJKA 3NKPA 5C66A 5L0KA 3UN5A 4UORA 1ZEBA 5HRTA 1URAA 1O99A
chains in the Genus database with same CATH superfamily
1KHJA 5L0BA 1KH7A 3T00A 4UPHA 3UO0A 1E33P 1E1ZP 1ZEDA 2G9YA 3LXQA 5K4PA 3TWZA 3BDGA 4LR2A 2VQRA 5LRMA 2D1GA 3MK2A 4LRCA 5EGHA 3IGYB 5GRRA 3WAYA 1KH9A 5TJ3A 4FDJA 4B56A 4GTWA 2W5XA 4LRBA 1HDHA 4MIVA 4CXSA 4NWXA 4LQYA 1KH5A 2GSOA 2ANHA 4ZGAA 2ZKTA 4LREA 3NKOA 4CXKA 3UN3A 4KJDA 3OT9A 2IFYA 3BDHA 1SHNA 3WAXA 4UPIA 4KM4A 5AJ9A 1ED9A 2X98A 5EGEA 3UN2A 1ANIA 1Y6VA 3M8YA 4FDIA 4LRFA 3NKQA 5DLTA 4YR1A 4LRAA 3WAWA 4CXUA 3NVLA 4UPKA 1EJJA 3A52A 2IUCB 3SZZA 1EI6A 2W5QA 5LRNA 1ELYA 5IJSA 1KHLA 1ELZA 1ALIA 3B5QA 1AJBA 5IJQA 1ALHA 1EW9A 2IUCA 2XRGA 1K7HA 3IGZB 3Q3QA 4ZG7A 3M8WA 3BDGB 2W5VA 1EW8A 1E2SP 3BDFA 4QAXA 5L0EA 2W5TA 2W8SA 3WAVA 2GSUA 2GLQA 2RH6A 3NKNA 4TN0A 2GSNA 4LR8A 4ZG6A 4UOOA 1URBA 2XR9A 3CMRA 2W5RA 5DLWA 3T01A 3NKMA 5LIAA 3M7VA 3TX0A 2W5SA 1Y7AA 2W5WA 1ALJA 1N2KA 4KAVA 1KH4A 3ED4A 3UNYA 4UPLA 4KJGA 5KXAA 4GTYA 5GOVA 1AJDA 1B8JA 4NWJA 3SZYA 4MHXA 3MK1A 4LR9A 5LQQA 4LRDA 4MY4A 3WBHA 3E2DA 2GA3A 4CYSA 1P49A 1O98A 1ANJA 3DYCA 1FSUA 3M8ZA 4CYRA 4ZG9A 3DPCA 1ZEFA 1HQAA 4GTZA 4GTXA 3KD8A 1N2LA 3T02A 3MK0A 1AJCA 5INHA 1AUKA 4N7TA 1AJAA 2QZUA 3TG0A 1EQJA 1SHQA 1KHKA 4LR7A 2W8DA 5DLVA 4UOPA 1EW2A 3IDDA 1KHNA 1ELXA 4KAYA 1ALKA 1ED8A 1E3CP 3NKRA 1HJKA 3NKPA 5C66A 5L0KA 3UN5A 4UORA 1ZEBA 5HRTA 1URAA 1O99A
chains in the Genus database with same CATH topology
1KHJA 5L0BA 1KH7A 3T00A 4UPHA 3UO0A 1E33P 1E1ZP 1ZEDA 2G9YA 3LXQA 5K4PA 3TWZA 3BDGA 4LR2A 2VQRA 5LRMA 2D1GA 3MK2A 4LRCA 5EGHA 3IGYB 5GRRA 3WAYA 1KH9A 5TJ3A 4FDJA 4B56A 4GTWA 2W5XA 4LRBA 1HDHA 4MIVA 4CXSA 4NWXA 4LQYA 1KH5A 2GSOA 2ANHA 4ZGAA 2ZKTA 4LREA 3NKOA 4CXKA 3UN3A 4KJDA 3OT9A 2IFYA 3BDHA 1SHNA 3WAXA 4UPIA 4KM4A 5AJ9A 1ED9A 2X98A 5EGEA 3UN2A 1ANIA 1Y6VA 3M8YA 4FDIA 4LRFA 3NKQA 5DLTA 4YR1A 4LRAA 3WAWA 4CXUA 3NVLA 4UPKA 1EJJA 3A52A 2IUCB 3SZZA 1EI6A 2W5QA 5LRNA 1ELYA 5IJSA 1KHLA 1ELZA 1ALIA 3B5QA 1AJBA 5IJQA 1ALHA 1EW9A 2IUCA 2XRGA 1K7HA 3IGZB 3Q3QA 4ZG7A 3M8WA 3BDGB 2W5VA 1EW8A 1E2SP 3BDFA 4QAXA 5L0EA 2W5TA 2W8SA 3WAVA 2GSUA 2GLQA 2RH6A 3NKNA 4TN0A 2GSNA 4LR8A 4ZG6A 4UOOA 1URBA 2XR9A 3CMRA 2W5RA 5DLWA 3T01A 3NKMA 5LIAA 3M7VA 3TX0A 2W5SA 1Y7AA 2W5WA 1ALJA 1N2KA 4KAVA 1KH4A 3ED4A 3UNYA 4UPLA 4KJGA 5KXAA 4GTYA 5GOVA 1AJDA 1B8JA 4NWJA 3SZYA 4MHXA 3MK1A 4LR9A 5LQQA 4LRDA 4MY4A 3WBHA 3E2DA 2GA3A 4CYSA 1P49A 1O98A 1ANJA 3DYCA 1FSUA 3M8ZA 4CYRA 4ZG9A 3DPCA 1ZEFA 1HQAA 4GTZA 4GTXA 3KD8A 1N2LA 3T02A 3MK0A 1AJCA 5INHA 1AUKA 4N7TA 1AJAA 2QZUA 3TG0A 1EQJA 1SHQA 1KHKA 4LR7A 2W8DA 5DLVA 4UOPA 1EW2A 3IDDA 1KHNA 1ELXA 4KAYA 1ALKA 1ED8A 1E3CP 3NKRA 1HJKA 3NKPA 5C66A 5L0KA 3UN5A 4UORA 1ZEBA 5HRTA 1URAA 1O99A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KHJ A;  5L0B A;  1KH7 A;  3T00 A;  4UPH A;  3UO0 A;  1E33 P;  1E1Z P;  1ZED A;  2G9Y A;  3LXQ A;  5K4P A;  3TWZ A;  3BDG A;  4LR2 A;  2VQR A;  5LRM A;  2D1G A;  3MK2 A;  4LRC A;  5EGH A;  3IGY B;  5GRR A;  3WAY A;  1KH9 A;  5TJ3 A;  4FDJ A;  4B56 A;  4GTW A;  2W5X A;  4LRB A;  1HDH A;  4MIV A;  4CXS A;  4NWX A;  4LQY A;  1KH5 A;  2GSO A;  2ANH A;  4ZGA A;  2ZKT A;  4LRE A;  3NKO A;  4CXK A;  3UN3 A;  4KJD A;  3OT9 A;  2IFY A;  3BDH A;  1SHN A;  3WAX A;  4UPI A;  4KM4 A;  5AJ9 A;  1ED9 A;  2X98 A;  5EGE A;  3UN2 A;  1ANI A;  1Y6V A;  3M8Y A;  4FDI A;  4LRF A;  3NKQ A;  5DLT A;  4YR1 A;  4LRA A;  3WAW A;  4CXU A;  3NVL A;  4UPK A;  1EJJ A;  3A52 A;  2IUC B;  3SZZ A;  1EI6 A;  2W5Q A;  5LRN A;  1ELY A;  5IJS A;  1KHL A;  1ELZ A;  1ALI A;  3B5Q A;  1AJB A;  5IJQ A;  1ALH A;  1EW9 A;  2IUC A;  2XRG A;  1K7H A;  3IGZ B;  3Q3Q A;  4ZG7 A;  3M8W A;  3BDG B;  2W5V A;  1EW8 A;  1E2S P;  3BDF A;  4QAX A;  5L0E A;  2W5T A;  2W8S A;  3WAV A;  2GSU A;  2GLQ A;  2RH6 A;  3NKN A;  4TN0 A;  2GSN A;  4LR8 A;  4ZG6 A;  4UOO A;  1URB A;  2XR9 A;  3CMR A;  2W5R A;  5DLW A;  3T01 A;  3NKM A;  5LIA A;  3M7V A;  3TX0 A;  2W5S A;  1Y7A A;  2W5W A;  1ALJ A;  1N2K A;  4KAV A;  1KH4 A;  3ED4 A;  3UNY A;  4UPL A;  4KJG A;  5KXA A;  4GTY A;  5GOV A;  1AJD A;  1B8J A;  4NWJ A;  3SZY A;  4MHX A;  3MK1 A;  4LR9 A;  5LQQ A;  4LRD A;  4MY4 A;  3WBH A;  3E2D A;  2GA3 A;  4CYS A;  1P49 A;  1O98 A;  1ANJ A;  3DYC A;  1FSU A;  3M8Z A;  4CYR A;  4ZG9 A;  3DPC A;  1ZEF A;  1HQA A;  4GTZ A;  4GTX A;  3KD8 A;  1N2L A;  3T02 A;  3MK0 A;  1AJC A;  5INH A;  1AUK A;  4N7T A;  1AJA A;  2QZU A;  3TG0 A;  1EQJ A;  1SHQ A;  1KHK A;  4LR7 A;  2W8D A;  5DLV A;  4UOP A;  1EW2 A;  3IDD A;  1KHN A;  1ELX A;  4KAY A;  1ALK A;  1ED8 A;  1E3C P;  3NKR A;  1HJK A;  3NKP A;  5C66 A;  5L0K A;  3UN5 A;  4UOR A;  1ZEB A;  5HRT A;  1URA A;  1O99 A; 
#chains in the Genus database with same CATH topology
 1KHJ A;  5L0B A;  1KH7 A;  3T00 A;  4UPH A;  3UO0 A;  1E33 P;  1E1Z P;  1ZED A;  2G9Y A;  3LXQ A;  5K4P A;  3TWZ A;  3BDG A;  4LR2 A;  2VQR A;  5LRM A;  2D1G A;  3MK2 A;  4LRC A;  5EGH A;  3IGY B;  5GRR A;  3WAY A;  1KH9 A;  5TJ3 A;  4FDJ A;  4B56 A;  4GTW A;  2W5X A;  4LRB A;  1HDH A;  4MIV A;  4CXS A;  4NWX A;  4LQY A;  1KH5 A;  2GSO A;  2ANH A;  4ZGA A;  2ZKT A;  4LRE A;  3NKO A;  4CXK A;  3UN3 A;  4KJD A;  3OT9 A;  2IFY A;  3BDH A;  1SHN A;  3WAX A;  4UPI A;  4KM4 A;  5AJ9 A;  1ED9 A;  2X98 A;  5EGE A;  3UN2 A;  1ANI A;  1Y6V A;  3M8Y A;  4FDI A;  4LRF A;  3NKQ A;  5DLT A;  4YR1 A;  4LRA A;  3WAW A;  4CXU A;  3NVL A;  4UPK A;  1EJJ A;  3A52 A;  2IUC B;  3SZZ A;  1EI6 A;  2W5Q A;  5LRN A;  1ELY A;  5IJS A;  1KHL A;  1ELZ A;  1ALI A;  3B5Q A;  1AJB A;  5IJQ A;  1ALH A;  1EW9 A;  2IUC A;  2XRG A;  1K7H A;  3IGZ B;  3Q3Q A;  4ZG7 A;  3M8W A;  3BDG B;  2W5V A;  1EW8 A;  1E2S P;  3BDF A;  4QAX A;  5L0E A;  2W5T A;  2W8S A;  3WAV A;  2GSU A;  2GLQ A;  2RH6 A;  3NKN A;  4TN0 A;  2GSN A;  4LR8 A;  4ZG6 A;  4UOO A;  1URB A;  2XR9 A;  3CMR A;  2W5R A;  5DLW A;  3T01 A;  3NKM A;  5LIA A;  3M7V A;  3TX0 A;  2W5S A;  1Y7A A;  2W5W A;  1ALJ A;  1N2K A;  4KAV A;  1KH4 A;  3ED4 A;  3UNY A;  4UPL A;  4KJG A;  5KXA A;  4GTY A;  5GOV A;  1AJD A;  1B8J A;  4NWJ A;  3SZY A;  4MHX A;  3MK1 A;  4LR9 A;  5LQQ A;  4LRD A;  4MY4 A;  3WBH A;  3E2D A;  2GA3 A;  4CYS A;  1P49 A;  1O98 A;  1ANJ A;  3DYC A;  1FSU A;  3M8Z A;  4CYR A;  4ZG9 A;  3DPC A;  1ZEF A;  1HQA A;  4GTZ A;  4GTX A;  3KD8 A;  1N2L A;  3T02 A;  3MK0 A;  1AJC A;  5INH A;  1AUK A;  4N7T A;  1AJA A;  2QZU A;  3TG0 A;  1EQJ A;  1SHQ A;  1KHK A;  4LR7 A;  2W8D A;  5DLV A;  4UOP A;  1EW2 A;  3IDD A;  1KHN A;  1ELX A;  4KAY A;  1ALK A;  1ED8 A;  1E3C P;  3NKR A;  1HJK A;  3NKP A;  5C66 A;  5L0K A;  3UN5 A;  4UOR A;  1ZEB A;  5HRT A;  1URA A;  1O99 A; 
#chains in the Genus database with same CATH homology
 1KHJ A;  5L0B A;  1KH7 A;  3T00 A;  4UPH A;  3UO0 A;  1E33 P;  1E1Z P;  1ZED A;  2G9Y A;  3LXQ A;  5K4P A;  3TWZ A;  3BDG A;  4LR2 A;  2VQR A;  5LRM A;  2D1G A;  3MK2 A;  4LRC A;  5EGH A;  3IGY B;  5GRR A;  3WAY A;  1KH9 A;  5TJ3 A;  4FDJ A;  4B56 A;  4GTW A;  2W5X A;  4LRB A;  1HDH A;  4MIV A;  4CXS A;  4NWX A;  4LQY A;  1KH5 A;  2GSO A;  2ANH A;  4ZGA A;  2ZKT A;  4LRE A;  3NKO A;  4CXK A;  3UN3 A;  4KJD A;  3OT9 A;  2IFY A;  3BDH A;  1SHN A;  3WAX A;  4UPI A;  4KM4 A;  5AJ9 A;  1ED9 A;  2X98 A;  5EGE A;  3UN2 A;  1ANI A;  1Y6V A;  3M8Y A;  4FDI A;  4LRF A;  3NKQ A;  5DLT A;  4YR1 A;  4LRA A;  3WAW A;  4CXU A;  3NVL A;  4UPK A;  1EJJ A;  3A52 A;  2IUC B;  3SZZ A;  1EI6 A;  2W5Q A;  5LRN A;  1ELY A;  5IJS A;  1KHL A;  1ELZ A;  1ALI A;  3B5Q A;  1AJB A;  5IJQ A;  1ALH A;  1EW9 A;  2IUC A;  2XRG A;  1K7H A;  3IGZ B;  3Q3Q A;  4ZG7 A;  3M8W A;  3BDG B;  2W5V A;  1EW8 A;  1E2S P;  3BDF A;  4QAX A;  5L0E A;  2W5T A;  2W8S A;  3WAV A;  2GSU A;  2GLQ A;  2RH6 A;  3NKN A;  4TN0 A;  2GSN A;  4LR8 A;  4ZG6 A;  4UOO A;  1URB A;  2XR9 A;  3CMR A;  2W5R A;  5DLW A;  3T01 A;  3NKM A;  5LIA A;  3M7V A;  3TX0 A;  2W5S A;  1Y7A A;  2W5W A;  1ALJ A;  1N2K A;  4KAV A;  1KH4 A;  3ED4 A;  3UNY A;  4UPL A;  4KJG A;  5KXA A;  4GTY A;  5GOV A;  1AJD A;  1B8J A;  4NWJ A;  3SZY A;  4MHX A;  3MK1 A;  4LR9 A;  5LQQ A;  4LRD A;  4MY4 A;  3WBH A;  3E2D A;  2GA3 A;  4CYS A;  1P49 A;  1O98 A;  1ANJ A;  3DYC A;  1FSU A;  3M8Z A;  4CYR A;  4ZG9 A;  3DPC A;  1ZEF A;  1HQA A;  4GTZ A;  4GTX A;  3KD8 A;  1N2L A;  3T02 A;  3MK0 A;  1AJC A;  5INH A;  1AUK A;  4N7T A;  1AJA A;  2QZU A;  3TG0 A;  1EQJ A;  1SHQ A;  1KHK A;  4LR7 A;  2W8D A;  5DLV A;  4UOP A;  1EW2 A;  3IDD A;  1KHN A;  1ELX A;  4KAY A;  1ALK A;  1ED8 A;  1E3C P;  3NKR A;  1HJK A;  3NKP A;  5C66 A;  5L0K A;  3UN5 A;  4UOR A;  1ZEB A;  5HRT A;  1URA A;  1O99 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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