1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule keywords Alkaline phosphatase
molecule tags Hydrolase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
3KD8A 1ELYA 3M8WA 5INHA 4LR2A 1EW9A 4FDIA 3SZZA 5IJSA 1ALHA 3A52A 4GTYA 3BDGB 4KJDA 1E3CP 4UOOA 1P49A 1EJJA 1KH7A 2W5RA 4LRFA 3MK0A 3OT9A 3BDFA 5AJ9A 5DLWA 2QZUA 5DLTA 3UN3A 4UORA 4YR1A 5L0EA 1O98A 1ANJA 1ELZA 4CXUA 3WAXA 3MK1A 2D1GA 5LRNA 1URBA 3T00A 4ZG6A 2IUCA 3TG0A 4KM4A 4CXSA 1ALIA 1K7HA 4B56A 4LREA 4UOPA 1AJAA 2X98A 3NKOA 4ZG7A 1EQJA 3IDDA 1ZEDA 4KAVA 2ANHA 5GOVA 1E33P 3BDHA 5LQQA 3NKRA 4LR9A 5DLVA 2W8DA 3SZYA 1AJCA 1AUKA 1HJKA 1ALJA 4LRBA 4LR8A 2W8SA 4CYRA 1KHKA 4UPIA 1Y7AA 1N2LA 2IUCB 4UPHA 5LIAA 3MK2A 4MIVA 1KH5A 1KH4A 3CMRA 3NKPA 5EGHA 1ZEBA 3DPCA 5L0BA 1E2SP 4UPKA 5TJ3A 3WAYA 2XR9A 3DYCA 3WAWA 4KJGA 4LRDA 1FSUA 1SHQA 4LRAA 2VQRA 1EW8A 4FDJA 1ED9A 1Y6VA 5LRMA 1KHLA 2W5SA 4NWJA 4UPLA 3UN2A 1KH9A 4KAYA 4MY4A 2IFYA 4LQYA 4QAXA 2GSOA 1HDHA 1KHJA 1SHNA 5K4PA 3UNYA 4CYSA 4LR7A 1HQAA 3NKQA 1ANIA 3NVLA 2W5WA 1URAA 1AJDA 1EI6A 2W5QA 4NWXA 1N2KA 1KHNA 3UN5A 1EW2A 5GRRA 1B8JA 3ED4A 4TN0A 3NKNA 5KXAA 3T01A 4CXKA 2GLQA 2GSUA 3TX0A 4GTZA 2G9YA 3B5QA 3TWZA 3WAVA 2GA3A 4GTXA 1ZEFA 3WBHA 4ZG9A 5HRTA 4MHXA 2W5TA 2GSNA 5EGEA 3LXQA 2ZKTA 1ALKA 2W5VA 4N7TA 3T02A 4LRCA 3BDGA 5L0KA 5IJQA 3NKMA 3E2DA 3IGZB 5C66A 1E1ZP 3M8ZA 3M8YA 1O99A 3UO0A 1ELXA 2RH6A 1ED8A 3IGYB 4GTWA 1AJBA 2XRGA 4ZGAA 2W5XA 3M7VA 3Q3QA
chains in the Genus database with same CATH superfamily
3KD8A 1ELYA 3M8WA 5INHA 4LR2A 1EW9A 4FDIA 3SZZA 5IJSA 1ALHA 3A52A 4GTYA 3BDGB 4KJDA 1E3CP 4UOOA 1P49A 1EJJA 1KH7A 2W5RA 4LRFA 3MK0A 3OT9A 3BDFA 5AJ9A 5DLWA 2QZUA 5DLTA 3UN3A 4UORA 4YR1A 5L0EA 1O98A 1ANJA 1ELZA 4CXUA 3WAXA 3MK1A 2D1GA 5LRNA 1URBA 3T00A 4ZG6A 2IUCA 3TG0A 4KM4A 4CXSA 1ALIA 1K7HA 4B56A 4LREA 4UOPA 1AJAA 2X98A 3NKOA 4ZG7A 1EQJA 3IDDA 1ZEDA 4KAVA 2ANHA 5GOVA 1E33P 3BDHA 5LQQA 3NKRA 4LR9A 5DLVA 2W8DA 3SZYA 1AJCA 1AUKA 1HJKA 1ALJA 4LRBA 4LR8A 2W8SA 4CYRA 1KHKA 4UPIA 1Y7AA 1N2LA 2IUCB 4UPHA 5LIAA 3MK2A 4MIVA 1KH5A 1KH4A 3CMRA 3NKPA 5EGHA 1ZEBA 3DPCA 5L0BA 1E2SP 4UPKA 5TJ3A 3WAYA 2XR9A 3DYCA 3WAWA 4KJGA 4LRDA 1FSUA 1SHQA 4LRAA 2VQRA 1EW8A 4FDJA 1ED9A 1Y6VA 5LRMA 1KHLA 2W5SA 4NWJA 4UPLA 3UN2A 1KH9A 4KAYA 4MY4A 2IFYA 4LQYA 4QAXA 2GSOA 1HDHA 1KHJA 1SHNA 5K4PA 3UNYA 4CYSA 4LR7A 1HQAA 3NKQA 1ANIA 3NVLA 2W5WA 1URAA 1AJDA 1EI6A 2W5QA 4NWXA 1N2KA 1KHNA 3UN5A 1EW2A 5GRRA 1B8JA 3ED4A 4TN0A 3NKNA 5KXAA 3T01A 4CXKA 2GLQA 2GSUA 3TX0A 4GTZA 2G9YA 3B5QA 3TWZA 3WAVA 2GA3A 4GTXA 1ZEFA 3WBHA 4ZG9A 5HRTA 4MHXA 2W5TA 2GSNA 5EGEA 3LXQA 2ZKTA 1ALKA 2W5VA 4N7TA 3T02A 4LRCA 3BDGA 5L0KA 5IJQA 3NKMA 3E2DA 3IGZB 5C66A 1E1ZP 3M8ZA 3M8YA 1O99A 3UO0A 1ELXA 2RH6A 1ED8A 3IGYB 4GTWA 1AJBA 2XRGA 4ZGAA 2W5XA 3M7VA 3Q3QA
chains in the Genus database with same CATH topology
3KD8A 1ELYA 3M8WA 5INHA 4LR2A 1EW9A 4FDIA 3SZZA 5IJSA 1ALHA 3A52A 4GTYA 3BDGB 4KJDA 1E3CP 4UOOA 1P49A 1EJJA 1KH7A 2W5RA 4LRFA 3MK0A 3OT9A 3BDFA 5AJ9A 5DLWA 2QZUA 5DLTA 3UN3A 4UORA 4YR1A 5L0EA 1O98A 1ANJA 1ELZA 4CXUA 3WAXA 3MK1A 2D1GA 5LRNA 1URBA 3T00A 4ZG6A 2IUCA 3TG0A 4KM4A 4CXSA 1ALIA 1K7HA 4B56A 4LREA 4UOPA 1AJAA 2X98A 3NKOA 4ZG7A 1EQJA 3IDDA 1ZEDA 4KAVA 2ANHA 5GOVA 1E33P 3BDHA 5LQQA 3NKRA 4LR9A 5DLVA 2W8DA 3SZYA 1AJCA 1AUKA 1HJKA 1ALJA 4LRBA 4LR8A 2W8SA 4CYRA 1KHKA 4UPIA 1Y7AA 1N2LA 2IUCB 4UPHA 5LIAA 3MK2A 4MIVA 1KH5A 1KH4A 3CMRA 3NKPA 5EGHA 1ZEBA 3DPCA 5L0BA 1E2SP 4UPKA 5TJ3A 3WAYA 2XR9A 3DYCA 3WAWA 4KJGA 4LRDA 1FSUA 1SHQA 4LRAA 2VQRA 1EW8A 4FDJA 1ED9A 1Y6VA 5LRMA 1KHLA 2W5SA 4NWJA 4UPLA 3UN2A 1KH9A 4KAYA 4MY4A 2IFYA 4LQYA 4QAXA 2GSOA 1HDHA 1KHJA 1SHNA 5K4PA 3UNYA 4CYSA 4LR7A 1HQAA 3NKQA 1ANIA 3NVLA 2W5WA 1URAA 1AJDA 1EI6A 2W5QA 4NWXA 1N2KA 1KHNA 3UN5A 1EW2A 5GRRA 1B8JA 3ED4A 4TN0A 3NKNA 5KXAA 3T01A 4CXKA 2GLQA 2GSUA 3TX0A 4GTZA 2G9YA 3B5QA 3TWZA 3WAVA 2GA3A 4GTXA 1ZEFA 3WBHA 4ZG9A 5HRTA 4MHXA 2W5TA 2GSNA 5EGEA 3LXQA 2ZKTA 1ALKA 2W5VA 4N7TA 3T02A 4LRCA 3BDGA 5L0KA 5IJQA 3NKMA 3E2DA 3IGZB 5C66A 1E1ZP 3M8ZA 3M8YA 1O99A 3UO0A 1ELXA 2RH6A 1ED8A 3IGYB 4GTWA 1AJBA 2XRGA 4ZGAA 2W5XA 3M7VA 3Q3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KD8 A;  1ELY A;  3M8W A;  5INH A;  4LR2 A;  1EW9 A;  4FDI A;  3SZZ A;  5IJS A;  1ALH A;  3A52 A;  4GTY A;  3BDG B;  4KJD A;  1E3C P;  4UOO A;  1P49 A;  1EJJ A;  1KH7 A;  2W5R A;  4LRF A;  3MK0 A;  3OT9 A;  3BDF A;  5AJ9 A;  5DLW A;  2QZU A;  5DLT A;  3UN3 A;  4UOR A;  4YR1 A;  5L0E A;  1O98 A;  1ANJ A;  1ELZ A;  4CXU A;  3WAX A;  3MK1 A;  2D1G A;  5LRN A;  1URB A;  3T00 A;  4ZG6 A;  2IUC A;  3TG0 A;  4KM4 A;  4CXS A;  1ALI A;  1K7H A;  4B56 A;  4LRE A;  4UOP A;  1AJA A;  2X98 A;  3NKO A;  4ZG7 A;  1EQJ A;  3IDD A;  1ZED A;  4KAV A;  2ANH A;  5GOV A;  1E33 P;  3BDH A;  5LQQ A;  3NKR A;  4LR9 A;  5DLV A;  2W8D A;  3SZY A;  1AJC A;  1AUK A;  1HJK A;  1ALJ A;  4LRB A;  4LR8 A;  2W8S A;  4CYR A;  1KHK A;  4UPI A;  1Y7A A;  1N2L A;  2IUC B;  4UPH A;  5LIA A;  3MK2 A;  4MIV A;  1KH5 A;  1KH4 A;  3CMR A;  3NKP A;  5EGH A;  1ZEB A;  3DPC A;  5L0B A;  1E2S P;  4UPK A;  5TJ3 A;  3WAY A;  2XR9 A;  3DYC A;  3WAW A;  4KJG A;  4LRD A;  1FSU A;  1SHQ A;  4LRA A;  2VQR A;  1EW8 A;  4FDJ A;  1ED9 A;  1Y6V A;  5LRM A;  1KHL A;  2W5S A;  4NWJ A;  4UPL A;  3UN2 A;  1KH9 A;  4KAY A;  4MY4 A;  2IFY A;  4LQY A;  4QAX A;  2GSO A;  1HDH A;  1KHJ A;  1SHN A;  5K4P A;  3UNY A;  4CYS A;  4LR7 A;  1HQA A;  3NKQ A;  1ANI A;  3NVL A;  2W5W A;  1URA A;  1AJD A;  1EI6 A;  2W5Q A;  4NWX A;  1N2K A;  1KHN A;  3UN5 A;  1EW2 A;  5GRR A;  1B8J A;  3ED4 A;  4TN0 A;  3NKN A;  5KXA A;  3T01 A;  4CXK A;  2GLQ A;  2GSU A;  3TX0 A;  4GTZ A;  2G9Y A;  3B5Q A;  3TWZ A;  3WAV A;  2GA3 A;  4GTX A;  1ZEF A;  3WBH A;  4ZG9 A;  5HRT A;  4MHX A;  2W5T A;  2GSN A;  5EGE A;  3LXQ A;  2ZKT A;  1ALK A;  2W5V A;  4N7T A;  3T02 A;  4LRC A;  3BDG A;  5L0K A;  5IJQ A;  3NKM A;  3E2D A;  3IGZ B;  5C66 A;  1E1Z P;  3M8Z A;  3M8Y A;  1O99 A;  3UO0 A;  1ELX A;  2RH6 A;  1ED8 A;  3IGY B;  4GTW A;  1AJB A;  2XRG A;  4ZGA A;  2W5X A;  3M7V A;  3Q3Q A; 
#chains in the Genus database with same CATH topology
 3KD8 A;  1ELY A;  3M8W A;  5INH A;  4LR2 A;  1EW9 A;  4FDI A;  3SZZ A;  5IJS A;  1ALH A;  3A52 A;  4GTY A;  3BDG B;  4KJD A;  1E3C P;  4UOO A;  1P49 A;  1EJJ A;  1KH7 A;  2W5R A;  4LRF A;  3MK0 A;  3OT9 A;  3BDF A;  5AJ9 A;  5DLW A;  2QZU A;  5DLT A;  3UN3 A;  4UOR A;  4YR1 A;  5L0E A;  1O98 A;  1ANJ A;  1ELZ A;  4CXU A;  3WAX A;  3MK1 A;  2D1G A;  5LRN A;  1URB A;  3T00 A;  4ZG6 A;  2IUC A;  3TG0 A;  4KM4 A;  4CXS A;  1ALI A;  1K7H A;  4B56 A;  4LRE A;  4UOP A;  1AJA A;  2X98 A;  3NKO A;  4ZG7 A;  1EQJ A;  3IDD A;  1ZED A;  4KAV A;  2ANH A;  5GOV A;  1E33 P;  3BDH A;  5LQQ A;  3NKR A;  4LR9 A;  5DLV A;  2W8D A;  3SZY A;  1AJC A;  1AUK A;  1HJK A;  1ALJ A;  4LRB A;  4LR8 A;  2W8S A;  4CYR A;  1KHK A;  4UPI A;  1Y7A A;  1N2L A;  2IUC B;  4UPH A;  5LIA A;  3MK2 A;  4MIV A;  1KH5 A;  1KH4 A;  3CMR A;  3NKP A;  5EGH A;  1ZEB A;  3DPC A;  5L0B A;  1E2S P;  4UPK A;  5TJ3 A;  3WAY A;  2XR9 A;  3DYC A;  3WAW A;  4KJG A;  4LRD A;  1FSU A;  1SHQ A;  4LRA A;  2VQR A;  1EW8 A;  4FDJ A;  1ED9 A;  1Y6V A;  5LRM A;  1KHL A;  2W5S A;  4NWJ A;  4UPL A;  3UN2 A;  1KH9 A;  4KAY A;  4MY4 A;  2IFY A;  4LQY A;  4QAX A;  2GSO A;  1HDH A;  1KHJ A;  1SHN A;  5K4P A;  3UNY A;  4CYS A;  4LR7 A;  1HQA A;  3NKQ A;  1ANI A;  3NVL A;  2W5W A;  1URA A;  1AJD A;  1EI6 A;  2W5Q A;  4NWX A;  1N2K A;  1KHN A;  3UN5 A;  1EW2 A;  5GRR A;  1B8J A;  3ED4 A;  4TN0 A;  3NKN A;  5KXA A;  3T01 A;  4CXK A;  2GLQ A;  2GSU A;  3TX0 A;  4GTZ A;  2G9Y A;  3B5Q A;  3TWZ A;  3WAV A;  2GA3 A;  4GTX A;  1ZEF A;  3WBH A;  4ZG9 A;  5HRT A;  4MHX A;  2W5T A;  2GSN A;  5EGE A;  3LXQ A;  2ZKT A;  1ALK A;  2W5V A;  4N7T A;  3T02 A;  4LRC A;  3BDG A;  5L0K A;  5IJQ A;  3NKM A;  3E2D A;  3IGZ B;  5C66 A;  1E1Z P;  3M8Z A;  3M8Y A;  1O99 A;  3UO0 A;  1ELX A;  2RH6 A;  1ED8 A;  3IGY B;  4GTW A;  1AJB A;  2XRG A;  4ZGA A;  2W5X A;  3M7V A;  3Q3Q A; 
#chains in the Genus database with same CATH homology
 3KD8 A;  1ELY A;  3M8W A;  5INH A;  4LR2 A;  1EW9 A;  4FDI A;  3SZZ A;  5IJS A;  1ALH A;  3A52 A;  4GTY A;  3BDG B;  4KJD A;  1E3C P;  4UOO A;  1P49 A;  1EJJ A;  1KH7 A;  2W5R A;  4LRF A;  3MK0 A;  3OT9 A;  3BDF A;  5AJ9 A;  5DLW A;  2QZU A;  5DLT A;  3UN3 A;  4UOR A;  4YR1 A;  5L0E A;  1O98 A;  1ANJ A;  1ELZ A;  4CXU A;  3WAX A;  3MK1 A;  2D1G A;  5LRN A;  1URB A;  3T00 A;  4ZG6 A;  2IUC A;  3TG0 A;  4KM4 A;  4CXS A;  1ALI A;  1K7H A;  4B56 A;  4LRE A;  4UOP A;  1AJA A;  2X98 A;  3NKO A;  4ZG7 A;  1EQJ A;  3IDD A;  1ZED A;  4KAV A;  2ANH A;  5GOV A;  1E33 P;  3BDH A;  5LQQ A;  3NKR A;  4LR9 A;  5DLV A;  2W8D A;  3SZY A;  1AJC A;  1AUK A;  1HJK A;  1ALJ A;  4LRB A;  4LR8 A;  2W8S A;  4CYR A;  1KHK A;  4UPI A;  1Y7A A;  1N2L A;  2IUC B;  4UPH A;  5LIA A;  3MK2 A;  4MIV A;  1KH5 A;  1KH4 A;  3CMR A;  3NKP A;  5EGH A;  1ZEB A;  3DPC A;  5L0B A;  1E2S P;  4UPK A;  5TJ3 A;  3WAY A;  2XR9 A;  3DYC A;  3WAW A;  4KJG A;  4LRD A;  1FSU A;  1SHQ A;  4LRA A;  2VQR A;  1EW8 A;  4FDJ A;  1ED9 A;  1Y6V A;  5LRM A;  1KHL A;  2W5S A;  4NWJ A;  4UPL A;  3UN2 A;  1KH9 A;  4KAY A;  4MY4 A;  2IFY A;  4LQY A;  4QAX A;  2GSO A;  1HDH A;  1KHJ A;  1SHN A;  5K4P A;  3UNY A;  4CYS A;  4LR7 A;  1HQA A;  3NKQ A;  1ANI A;  3NVL A;  2W5W A;  1URA A;  1AJD A;  1EI6 A;  2W5Q A;  4NWX A;  1N2K A;  1KHN A;  3UN5 A;  1EW2 A;  5GRR A;  1B8J A;  3ED4 A;  4TN0 A;  3NKN A;  5KXA A;  3T01 A;  4CXK A;  2GLQ A;  2GSU A;  3TX0 A;  4GTZ A;  2G9Y A;  3B5Q A;  3TWZ A;  3WAV A;  2GA3 A;  4GTX A;  1ZEF A;  3WBH A;  4ZG9 A;  5HRT A;  4MHX A;  2W5T A;  2GSN A;  5EGE A;  3LXQ A;  2ZKT A;  1ALK A;  2W5V A;  4N7T A;  3T02 A;  4LRC A;  3BDG A;  5L0K A;  5IJQ A;  3NKM A;  3E2D A;  3IGZ B;  5C66 A;  1E1Z P;  3M8Z A;  3M8Y A;  1O99 A;  3UO0 A;  1ELX A;  2RH6 A;  1ED8 A;  3IGY B;  4GTW A;  1AJB A;  2XRG A;  4ZGA A;  2W5X A;  3M7V A;  3Q3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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