1EW8A

Alkaline phosphatase (e.c. 3.1.3.1) complex with phosphonoacetic acid
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
total genus 155
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew8A00
4FDJA 3B5QA 4UOOA 2IFYA 3BDHA 4QAXA 3UN3A 3WAWA 4B56A 1KH7A 3BDGA 3SZYA 4KJGA 1ANIA 2W5SA 3WAYA 2W5VA 1AJDA 5IJQA 3M8YA 3NKPA 3NKNA 5LRNA 4KJDA 3UNYA 2GSNA 3IGZB 4LR8A 5DLVA 5K4PA 3NKOA 4YR1A 4GTZA 5L0KA 4KAYA 1HJKA 3TWZA 3DYCA 4ZG9A 4CYRA 3T01A 2ANHA 3UN2A 5LQQA 1E2SP 1ALJA 3KD8A 1EW9A 2GLQA 1AUKA 2XR9A 4TN0A 4UPHA 1Y7AA 2X98A 1KHKA 1HQAA 1ANJA 4UORA 5DLWA 3WAXA 5IJSA 4LRCA 1EQJA 3LXQA 4KAVA 1E1ZP 3A52A 3OT9A 4GTYA 3CMRA 2G9YA 2GA3A 1EW2A 3WAVA 5LIAA 1ZEDA 2QZUA 5GOVA 3NKMA 3M8ZA 1ALHA 2W5QA 4LR9A 3T00A 4LQYA 4LRAA 5L0BA 2GSOA 1E3CP 5AJ9A 2W5XA 2W8DA 4NWJA 3TG0A 2IUCB 4LREA 1O98A 2XRGA 4GTWA 4FDIA 4ZG6A 5INHA 1ELYA 1ED9A 1ZEBA 1N2LA 1O99A 3ED4A 3MK1A 4UPKA 1ELXA 1SHQA 1KHNA 3M8WA 4NWXA 3WBHA 2RH6A 1ED8A 1K7HA 1FSUA 4UOPA 3T02A 3UN5A 4GTXA 4KM4A 2ZKTA 4LR7A 4LRDA 1HDHA 2W5TA 4MY4A 3IDDA 4CYSA 4UPIA 2GSUA 5EGEA 2IUCA 2VQRA 3UO0A 4ZGAA 1KHJA 5EGHA 1SHNA 4LRFA 1URBA 1URAA 3E2DA 1E33P 1KHLA 1ALKA 2W5WA 4LR2A 4LRBA 1AJAA 4CXUA 5C66A 1AJCA 4N7TA 1KH4A 3MK0A 1KH9A 1P49A 3SZZA 5DLTA 1KH5A 3NKQA 4MIVA 3Q3QA 1EI6A 4ZG7A 3M7VA 1AJBA 1Y6VA 3DPCA 1B8JA 4CXKA 1ALIA 3BDGB 3MK2A 1EW8A 2D1GA 4UPLA 5HRTA 2W8SA 2W5RA 3NVLA 1ELZA 5GRRA 4CXSA 3BDFA 4MHXA 5TJ3A 3TX0A 1N2KA 3IGYB 5LRMA 5KXAA 1EJJA 5L0EA 3NKRA 1ZEFA
chains in the Genus database with same CATH superfamily
4FDJA 3B5QA 4UOOA 2IFYA 3BDHA 4QAXA 3UN3A 3WAWA 4B56A 1KH7A 3BDGA 3SZYA 4KJGA 1ANIA 2W5SA 3WAYA 2W5VA 1AJDA 5IJQA 3M8YA 3NKPA 3NKNA 5LRNA 4KJDA 3UNYA 2GSNA 3IGZB 4LR8A 5DLVA 5K4PA 3NKOA 4YR1A 4GTZA 5L0KA 4KAYA 1HJKA 3TWZA 3DYCA 4ZG9A 4CYRA 3T01A 2ANHA 3UN2A 5LQQA 1E2SP 1ALJA 3KD8A 1EW9A 2GLQA 1AUKA 2XR9A 4TN0A 4UPHA 1Y7AA 2X98A 1KHKA 1HQAA 1ANJA 4UORA 5DLWA 3WAXA 5IJSA 4LRCA 1EQJA 3LXQA 4KAVA 1E1ZP 3A52A 3OT9A 4GTYA 3CMRA 2G9YA 2GA3A 1EW2A 3WAVA 5LIAA 1ZEDA 2QZUA 5GOVA 3NKMA 3M8ZA 1ALHA 2W5QA 4LR9A 3T00A 4LQYA 4LRAA 5L0BA 2GSOA 1E3CP 5AJ9A 2W5XA 2W8DA 4NWJA 3TG0A 2IUCB 4LREA 1O98A 2XRGA 4GTWA 4FDIA 4ZG6A 5INHA 1ELYA 1ED9A 1ZEBA 1N2LA 1O99A 3ED4A 3MK1A 4UPKA 1ELXA 1SHQA 1KHNA 3M8WA 4NWXA 3WBHA 2RH6A 1ED8A 1K7HA 1FSUA 4UOPA 3T02A 3UN5A 4GTXA 4KM4A 2ZKTA 4LR7A 4LRDA 1HDHA 2W5TA 4MY4A 3IDDA 4CYSA 4UPIA 2GSUA 5EGEA 2IUCA 2VQRA 3UO0A 4ZGAA 1KHJA 5EGHA 1SHNA 4LRFA 1URBA 1URAA 3E2DA 1E33P 1KHLA 1ALKA 2W5WA 4LR2A 4LRBA 1AJAA 4CXUA 5C66A 1AJCA 4N7TA 1KH4A 3MK0A 1KH9A 1P49A 3SZZA 5DLTA 1KH5A 3NKQA 4MIVA 3Q3QA 1EI6A 4ZG7A 3M7VA 1AJBA 1Y6VA 3DPCA 1B8JA 4CXKA 1ALIA 3BDGB 3MK2A 1EW8A 2D1GA 4UPLA 5HRTA 2W8SA 2W5RA 3NVLA 1ELZA 5GRRA 4CXSA 3BDFA 4MHXA 5TJ3A 3TX0A 1N2KA 3IGYB 5LRMA 5KXAA 1EJJA 5L0EA 3NKRA 1ZEFA
chains in the Genus database with same CATH topology
4FDJA 3B5QA 4UOOA 2IFYA 3BDHA 4QAXA 3UN3A 3WAWA 4B56A 1KH7A 3BDGA 3SZYA 4KJGA 1ANIA 2W5SA 3WAYA 2W5VA 1AJDA 5IJQA 3M8YA 3NKPA 3NKNA 5LRNA 4KJDA 3UNYA 2GSNA 3IGZB 4LR8A 5DLVA 5K4PA 3NKOA 4YR1A 4GTZA 5L0KA 4KAYA 1HJKA 3TWZA 3DYCA 4ZG9A 4CYRA 3T01A 2ANHA 3UN2A 5LQQA 1E2SP 1ALJA 3KD8A 1EW9A 2GLQA 1AUKA 2XR9A 4TN0A 4UPHA 1Y7AA 2X98A 1KHKA 1HQAA 1ANJA 4UORA 5DLWA 3WAXA 5IJSA 4LRCA 1EQJA 3LXQA 4KAVA 1E1ZP 3A52A 3OT9A 4GTYA 3CMRA 2G9YA 2GA3A 1EW2A 3WAVA 5LIAA 1ZEDA 2QZUA 5GOVA 3NKMA 3M8ZA 1ALHA 2W5QA 4LR9A 3T00A 4LQYA 4LRAA 5L0BA 2GSOA 1E3CP 5AJ9A 2W5XA 2W8DA 4NWJA 3TG0A 2IUCB 4LREA 1O98A 2XRGA 4GTWA 4FDIA 4ZG6A 5INHA 1ELYA 1ED9A 1ZEBA 1N2LA 1O99A 3ED4A 3MK1A 4UPKA 1ELXA 1SHQA 1KHNA 3M8WA 4NWXA 3WBHA 2RH6A 1ED8A 1K7HA 1FSUA 4UOPA 3T02A 3UN5A 4GTXA 4KM4A 2ZKTA 4LR7A 4LRDA 1HDHA 2W5TA 4MY4A 3IDDA 4CYSA 4UPIA 2GSUA 5EGEA 2IUCA 2VQRA 3UO0A 4ZGAA 1KHJA 5EGHA 1SHNA 4LRFA 1URBA 1URAA 3E2DA 1E33P 1KHLA 1ALKA 2W5WA 4LR2A 4LRBA 1AJAA 4CXUA 5C66A 1AJCA 4N7TA 1KH4A 3MK0A 1KH9A 1P49A 3SZZA 5DLTA 1KH5A 3NKQA 4MIVA 3Q3QA 1EI6A 4ZG7A 3M7VA 1AJBA 1Y6VA 3DPCA 1B8JA 4CXKA 1ALIA 3BDGB 3MK2A 1EW8A 2D1GA 4UPLA 5HRTA 2W8SA 2W5RA 3NVLA 1ELZA 5GRRA 4CXSA 3BDFA 4MHXA 5TJ3A 3TX0A 1N2KA 3IGYB 5LRMA 5KXAA 1EJJA 5L0EA 3NKRA 1ZEFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FDJ A;  3B5Q A;  4UOO A;  2IFY A;  3BDH A;  4QAX A;  3UN3 A;  3WAW A;  4B56 A;  1KH7 A;  3BDG A;  3SZY A;  4KJG A;  1ANI A;  2W5S A;  3WAY A;  2W5V A;  1AJD A;  5IJQ A;  3M8Y A;  3NKP A;  3NKN A;  5LRN A;  4KJD A;  3UNY A;  2GSN A;  3IGZ B;  4LR8 A;  5DLV A;  5K4P A;  3NKO A;  4YR1 A;  4GTZ A;  5L0K A;  4KAY A;  1HJK A;  3TWZ A;  3DYC A;  4ZG9 A;  4CYR A;  3T01 A;  2ANH A;  3UN2 A;  5LQQ A;  1E2S P;  1ALJ A;  3KD8 A;  1EW9 A;  2GLQ A;  1AUK A;  2XR9 A;  4TN0 A;  4UPH A;  1Y7A A;  2X98 A;  1KHK A;  1HQA A;  1ANJ A;  4UOR A;  5DLW A;  3WAX A;  5IJS A;  4LRC A;  1EQJ A;  3LXQ A;  4KAV A;  1E1Z P;  3A52 A;  3OT9 A;  4GTY A;  3CMR A;  2G9Y A;  2GA3 A;  1EW2 A;  3WAV A;  5LIA A;  1ZED A;  2QZU A;  5GOV A;  3NKM A;  3M8Z A;  1ALH A;  2W5Q A;  4LR9 A;  3T00 A;  4LQY A;  4LRA A;  5L0B A;  2GSO A;  1E3C P;  5AJ9 A;  2W5X A;  2W8D A;  4NWJ A;  3TG0 A;  2IUC B;  4LRE A;  1O98 A;  2XRG A;  4GTW A;  4FDI A;  4ZG6 A;  5INH A;  1ELY A;  1ED9 A;  1ZEB A;  1N2L A;  1O99 A;  3ED4 A;  3MK1 A;  4UPK A;  1ELX A;  1SHQ A;  1KHN A;  3M8W A;  4NWX A;  3WBH A;  2RH6 A;  1ED8 A;  1K7H A;  1FSU A;  4UOP A;  3T02 A;  3UN5 A;  4GTX A;  4KM4 A;  2ZKT A;  4LR7 A;  4LRD A;  1HDH A;  2W5T A;  4MY4 A;  3IDD A;  4CYS A;  4UPI A;  2GSU A;  5EGE A;  2IUC A;  2VQR A;  3UO0 A;  4ZGA A;  1KHJ A;  5EGH A;  1SHN A;  4LRF A;  1URB A;  1URA A;  3E2D A;  1E33 P;  1KHL A;  1ALK A;  2W5W A;  4LR2 A;  4LRB A;  1AJA A;  4CXU A;  5C66 A;  1AJC A;  4N7T A;  1KH4 A;  3MK0 A;  1KH9 A;  1P49 A;  3SZZ A;  5DLT A;  1KH5 A;  3NKQ A;  4MIV A;  3Q3Q A;  1EI6 A;  4ZG7 A;  3M7V A;  1AJB A;  1Y6V A;  3DPC A;  1B8J A;  4CXK A;  1ALI A;  3BDG B;  3MK2 A;  1EW8 A;  2D1G A;  4UPL A;  5HRT A;  2W8S A;  2W5R A;  3NVL A;  1ELZ A;  5GRR A;  4CXS A;  3BDF A;  4MHX A;  5TJ3 A;  3TX0 A;  1N2K A;  3IGY B;  5LRM A;  5KXA A;  1EJJ A;  5L0E A;  3NKR A;  1ZEF A; 
#chains in the Genus database with same CATH topology
 4FDJ A;  3B5Q A;  4UOO A;  2IFY A;  3BDH A;  4QAX A;  3UN3 A;  3WAW A;  4B56 A;  1KH7 A;  3BDG A;  3SZY A;  4KJG A;  1ANI A;  2W5S A;  3WAY A;  2W5V A;  1AJD A;  5IJQ A;  3M8Y A;  3NKP A;  3NKN A;  5LRN A;  4KJD A;  3UNY A;  2GSN A;  3IGZ B;  4LR8 A;  5DLV A;  5K4P A;  3NKO A;  4YR1 A;  4GTZ A;  5L0K A;  4KAY A;  1HJK A;  3TWZ A;  3DYC A;  4ZG9 A;  4CYR A;  3T01 A;  2ANH A;  3UN2 A;  5LQQ A;  1E2S P;  1ALJ A;  3KD8 A;  1EW9 A;  2GLQ A;  1AUK A;  2XR9 A;  4TN0 A;  4UPH A;  1Y7A A;  2X98 A;  1KHK A;  1HQA A;  1ANJ A;  4UOR A;  5DLW A;  3WAX A;  5IJS A;  4LRC A;  1EQJ A;  3LXQ A;  4KAV A;  1E1Z P;  3A52 A;  3OT9 A;  4GTY A;  3CMR A;  2G9Y A;  2GA3 A;  1EW2 A;  3WAV A;  5LIA A;  1ZED A;  2QZU A;  5GOV A;  3NKM A;  3M8Z A;  1ALH A;  2W5Q A;  4LR9 A;  3T00 A;  4LQY A;  4LRA A;  5L0B A;  2GSO A;  1E3C P;  5AJ9 A;  2W5X A;  2W8D A;  4NWJ A;  3TG0 A;  2IUC B;  4LRE A;  1O98 A;  2XRG A;  4GTW A;  4FDI A;  4ZG6 A;  5INH A;  1ELY A;  1ED9 A;  1ZEB A;  1N2L A;  1O99 A;  3ED4 A;  3MK1 A;  4UPK A;  1ELX A;  1SHQ A;  1KHN A;  3M8W A;  4NWX A;  3WBH A;  2RH6 A;  1ED8 A;  1K7H A;  1FSU A;  4UOP A;  3T02 A;  3UN5 A;  4GTX A;  4KM4 A;  2ZKT A;  4LR7 A;  4LRD A;  1HDH A;  2W5T A;  4MY4 A;  3IDD A;  4CYS A;  4UPI A;  2GSU A;  5EGE A;  2IUC A;  2VQR A;  3UO0 A;  4ZGA A;  1KHJ A;  5EGH A;  1SHN A;  4LRF A;  1URB A;  1URA A;  3E2D A;  1E33 P;  1KHL A;  1ALK A;  2W5W A;  4LR2 A;  4LRB A;  1AJA A;  4CXU A;  5C66 A;  1AJC A;  4N7T A;  1KH4 A;  3MK0 A;  1KH9 A;  1P49 A;  3SZZ A;  5DLT A;  1KH5 A;  3NKQ A;  4MIV A;  3Q3Q A;  1EI6 A;  4ZG7 A;  3M7V A;  1AJB A;  1Y6V A;  3DPC A;  1B8J A;  4CXK A;  1ALI A;  3BDG B;  3MK2 A;  1EW8 A;  2D1G A;  4UPL A;  5HRT A;  2W8S A;  2W5R A;  3NVL A;  1ELZ A;  5GRR A;  4CXS A;  3BDF A;  4MHX A;  5TJ3 A;  3TX0 A;  1N2K A;  3IGY B;  5LRM A;  5KXA A;  1EJJ A;  5L0E A;  3NKR A;  1ZEF A; 
#chains in the Genus database with same CATH homology
 4FDJ A;  3B5Q A;  4UOO A;  2IFY A;  3BDH A;  4QAX A;  3UN3 A;  3WAW A;  4B56 A;  1KH7 A;  3BDG A;  3SZY A;  4KJG A;  1ANI A;  2W5S A;  3WAY A;  2W5V A;  1AJD A;  5IJQ A;  3M8Y A;  3NKP A;  3NKN A;  5LRN A;  4KJD A;  3UNY A;  2GSN A;  3IGZ B;  4LR8 A;  5DLV A;  5K4P A;  3NKO A;  4YR1 A;  4GTZ A;  5L0K A;  4KAY A;  1HJK A;  3TWZ A;  3DYC A;  4ZG9 A;  4CYR A;  3T01 A;  2ANH A;  3UN2 A;  5LQQ A;  1E2S P;  1ALJ A;  3KD8 A;  1EW9 A;  2GLQ A;  1AUK A;  2XR9 A;  4TN0 A;  4UPH A;  1Y7A A;  2X98 A;  1KHK A;  1HQA A;  1ANJ A;  4UOR A;  5DLW A;  3WAX A;  5IJS A;  4LRC A;  1EQJ A;  3LXQ A;  4KAV A;  1E1Z P;  3A52 A;  3OT9 A;  4GTY A;  3CMR A;  2G9Y A;  2GA3 A;  1EW2 A;  3WAV A;  5LIA A;  1ZED A;  2QZU A;  5GOV A;  3NKM A;  3M8Z A;  1ALH A;  2W5Q A;  4LR9 A;  3T00 A;  4LQY A;  4LRA A;  5L0B A;  2GSO A;  1E3C P;  5AJ9 A;  2W5X A;  2W8D A;  4NWJ A;  3TG0 A;  2IUC B;  4LRE A;  1O98 A;  2XRG A;  4GTW A;  4FDI A;  4ZG6 A;  5INH A;  1ELY A;  1ED9 A;  1ZEB A;  1N2L A;  1O99 A;  3ED4 A;  3MK1 A;  4UPK A;  1ELX A;  1SHQ A;  1KHN A;  3M8W A;  4NWX A;  3WBH A;  2RH6 A;  1ED8 A;  1K7H A;  1FSU A;  4UOP A;  3T02 A;  3UN5 A;  4GTX A;  4KM4 A;  2ZKT A;  4LR7 A;  4LRD A;  1HDH A;  2W5T A;  4MY4 A;  3IDD A;  4CYS A;  4UPI A;  2GSU A;  5EGE A;  2IUC A;  2VQR A;  3UO0 A;  4ZGA A;  1KHJ A;  5EGH A;  1SHN A;  4LRF A;  1URB A;  1URA A;  3E2D A;  1E33 P;  1KHL A;  1ALK A;  2W5W A;  4LR2 A;  4LRB A;  1AJA A;  4CXU A;  5C66 A;  1AJC A;  4N7T A;  1KH4 A;  3MK0 A;  1KH9 A;  1P49 A;  3SZZ A;  5DLT A;  1KH5 A;  3NKQ A;  4MIV A;  3Q3Q A;  1EI6 A;  4ZG7 A;  3M7V A;  1AJB A;  1Y6V A;  3DPC A;  1B8J A;  4CXK A;  1ALI A;  3BDG B;  3MK2 A;  1EW8 A;  2D1G A;  4UPL A;  5HRT A;  2W8S A;  2W5R A;  3NVL A;  1ELZ A;  5GRR A;  4CXS A;  3BDF A;  4MHX A;  5TJ3 A;  3TX0 A;  1N2K A;  3IGY B;  5LRM A;  5KXA A;  1EJJ A;  5L0E A;  3NKR A;  1ZEF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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