1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
source organism Escherichia coli
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
4LRDA 2GSOA 4LR7A 5INHA 5DLVA 2IFYA 3IGYB 3WAYA 1E3CP 1N2KA 4NWJA 2IUCB 5EGEA 4LR2A 3UN2A 3TG0A 5L0EA 5AJ9A 1AUKA 2GSUA 3M8WA 4UORA 4UPKA 4GTXA 5K4PA 1ZEDA 1EJJA 2W5RA 5LRNA 4B56A 4LREA 4GTWA 5IJQA 5KXAA 1ANIA 5HRTA 1B8JA 3WBHA 1ZEBA 3MK2A 1ALJA 3DYCA 3SZZA 1AJAA 3UN3A 4MIVA 1AJBA 3NKQA 2GA3A 1ZEFA 3A52A 4QAXA 1O99A 4UPLA 4ZG6A 3IGZB 4LRCA 1KH5A 1SHQA 2IUCA 3ED4A 3SZYA 4LRAA 1KHLA 2D1GA 4KAVA 4TN0A 5GOVA 2GSNA 3BDGB 3M7VA 3DPCA 1ANJA 4UPIA 3Q3QA 1N2LA 4MY4A 1E2SP 1E33P 1EW2A 1P49A 2W5SA 1KHKA 2W8SA 1SHNA 5TJ3A 3NKNA 3E2DA 3CMRA 2X98A 1FSUA 3B5QA 4CXKA 3WAXA 2W5WA 3M8ZA 4LQYA 1ALIA 2ZKTA 1KH4A 1EQJA 1E1ZP 1EW8A 3UN5A 1AJCA 2QZUA 1EW9A 5EGHA 1HDHA 3KD8A 2W5XA 3BDGA 1KHNA 4YR1A 5IJSA 1KH7A 1Y6VA 1ELZA 3NKOA 1ED9A 3OT9A 1EI6A 2GLQA 4KJDA 2W5VA 5LRMA 1O98A 5DLTA 2W8DA 3T01A 4UOPA 4GTYA 4KM4A 1K7HA 2RH6A 4CYRA 2W5TA 2ANHA 3M8YA 2VQRA 1ELXA 3TWZA 5L0KA 1ALKA 1KHJA 1ED8A 4NWXA 5LQQA 4FDJA 1ELYA 3BDFA 4LR9A 3T00A 5GRRA 5LIAA 3MK1A 4KAYA 4LRFA 3T02A 5C66A 1Y7AA 1HJKA 4LRBA 3LXQA 1KH9A 3WAVA 1HQAA 4CXSA 2XR9A 4UPHA 4KJGA 3WAWA 3UNYA 3NKMA 3NVLA 3NKPA 1AJDA 4N7TA 2XRGA 4CXUA 4FDIA 3TX0A 1URAA 4MHXA 1ALHA 4ZGAA 4ZG7A 1URBA 3NKRA 4UOOA 3IDDA 3UO0A 5DLWA 4GTZA 4CYSA 5L0BA 2W5QA 4ZG9A 3MK0A 2G9YA 3BDHA 4LR8A
chains in the Genus database with same CATH superfamily
4LRDA 2GSOA 4LR7A 5INHA 5DLVA 2IFYA 3IGYB 3WAYA 1E3CP 1N2KA 4NWJA 2IUCB 5EGEA 4LR2A 3UN2A 3TG0A 5L0EA 5AJ9A 1AUKA 2GSUA 3M8WA 4UORA 4UPKA 4GTXA 5K4PA 1ZEDA 1EJJA 2W5RA 5LRNA 4B56A 4LREA 4GTWA 5IJQA 5KXAA 1ANIA 5HRTA 1B8JA 3WBHA 1ZEBA 3MK2A 1ALJA 3DYCA 3SZZA 1AJAA 3UN3A 4MIVA 1AJBA 3NKQA 2GA3A 1ZEFA 3A52A 4QAXA 1O99A 4UPLA 4ZG6A 3IGZB 4LRCA 1KH5A 1SHQA 2IUCA 3ED4A 3SZYA 4LRAA 1KHLA 2D1GA 4KAVA 4TN0A 5GOVA 2GSNA 3BDGB 3M7VA 3DPCA 1ANJA 4UPIA 3Q3QA 1N2LA 4MY4A 1E2SP 1E33P 1EW2A 1P49A 2W5SA 1KHKA 2W8SA 1SHNA 5TJ3A 3NKNA 3E2DA 3CMRA 2X98A 1FSUA 3B5QA 4CXKA 3WAXA 2W5WA 3M8ZA 4LQYA 1ALIA 2ZKTA 1KH4A 1EQJA 1E1ZP 1EW8A 3UN5A 1AJCA 2QZUA 1EW9A 5EGHA 1HDHA 3KD8A 2W5XA 3BDGA 1KHNA 4YR1A 5IJSA 1KH7A 1Y6VA 1ELZA 3NKOA 1ED9A 3OT9A 1EI6A 2GLQA 4KJDA 2W5VA 5LRMA 1O98A 5DLTA 2W8DA 3T01A 4UOPA 4GTYA 4KM4A 1K7HA 2RH6A 4CYRA 2W5TA 2ANHA 3M8YA 2VQRA 1ELXA 3TWZA 5L0KA 1ALKA 1KHJA 1ED8A 4NWXA 5LQQA 4FDJA 1ELYA 3BDFA 4LR9A 3T00A 5GRRA 5LIAA 3MK1A 4KAYA 4LRFA 3T02A 5C66A 1Y7AA 1HJKA 4LRBA 3LXQA 1KH9A 3WAVA 1HQAA 4CXSA 2XR9A 4UPHA 4KJGA 3WAWA 3UNYA 3NKMA 3NVLA 3NKPA 1AJDA 4N7TA 2XRGA 4CXUA 4FDIA 3TX0A 1URAA 4MHXA 1ALHA 4ZGAA 4ZG7A 1URBA 3NKRA 4UOOA 3IDDA 3UO0A 5DLWA 4GTZA 4CYSA 5L0BA 2W5QA 4ZG9A 3MK0A 2G9YA 3BDHA 4LR8A
chains in the Genus database with same CATH topology
4LRDA 2GSOA 4LR7A 5INHA 5DLVA 2IFYA 3IGYB 3WAYA 1E3CP 1N2KA 4NWJA 2IUCB 5EGEA 4LR2A 3UN2A 3TG0A 5L0EA 5AJ9A 1AUKA 2GSUA 3M8WA 4UORA 4UPKA 4GTXA 5K4PA 1ZEDA 1EJJA 2W5RA 5LRNA 4B56A 4LREA 4GTWA 5IJQA 5KXAA 1ANIA 5HRTA 1B8JA 3WBHA 1ZEBA 3MK2A 1ALJA 3DYCA 3SZZA 1AJAA 3UN3A 4MIVA 1AJBA 3NKQA 2GA3A 1ZEFA 3A52A 4QAXA 1O99A 4UPLA 4ZG6A 3IGZB 4LRCA 1KH5A 1SHQA 2IUCA 3ED4A 3SZYA 4LRAA 1KHLA 2D1GA 4KAVA 4TN0A 5GOVA 2GSNA 3BDGB 3M7VA 3DPCA 1ANJA 4UPIA 3Q3QA 1N2LA 4MY4A 1E2SP 1E33P 1EW2A 1P49A 2W5SA 1KHKA 2W8SA 1SHNA 5TJ3A 3NKNA 3E2DA 3CMRA 2X98A 1FSUA 3B5QA 4CXKA 3WAXA 2W5WA 3M8ZA 4LQYA 1ALIA 2ZKTA 1KH4A 1EQJA 1E1ZP 1EW8A 3UN5A 1AJCA 2QZUA 1EW9A 5EGHA 1HDHA 3KD8A 2W5XA 3BDGA 1KHNA 4YR1A 5IJSA 1KH7A 1Y6VA 1ELZA 3NKOA 1ED9A 3OT9A 1EI6A 2GLQA 4KJDA 2W5VA 5LRMA 1O98A 5DLTA 2W8DA 3T01A 4UOPA 4GTYA 4KM4A 1K7HA 2RH6A 4CYRA 2W5TA 2ANHA 3M8YA 2VQRA 1ELXA 3TWZA 5L0KA 1ALKA 1KHJA 1ED8A 4NWXA 5LQQA 4FDJA 1ELYA 3BDFA 4LR9A 3T00A 5GRRA 5LIAA 3MK1A 4KAYA 4LRFA 3T02A 5C66A 1Y7AA 1HJKA 4LRBA 3LXQA 1KH9A 3WAVA 1HQAA 4CXSA 2XR9A 4UPHA 4KJGA 3WAWA 3UNYA 3NKMA 3NVLA 3NKPA 1AJDA 4N7TA 2XRGA 4CXUA 4FDIA 3TX0A 1URAA 4MHXA 1ALHA 4ZGAA 4ZG7A 1URBA 3NKRA 4UOOA 3IDDA 3UO0A 5DLWA 4GTZA 4CYSA 5L0BA 2W5QA 4ZG9A 3MK0A 2G9YA 3BDHA 4LR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRD A;  2GSO A;  4LR7 A;  5INH A;  5DLV A;  2IFY A;  3IGY B;  3WAY A;  1E3C P;  1N2K A;  4NWJ A;  2IUC B;  5EGE A;  4LR2 A;  3UN2 A;  3TG0 A;  5L0E A;  5AJ9 A;  1AUK A;  2GSU A;  3M8W A;  4UOR A;  4UPK A;  4GTX A;  5K4P A;  1ZED A;  1EJJ A;  2W5R A;  5LRN A;  4B56 A;  4LRE A;  4GTW A;  5IJQ A;  5KXA A;  1ANI A;  5HRT A;  1B8J A;  3WBH A;  1ZEB A;  3MK2 A;  1ALJ A;  3DYC A;  3SZZ A;  1AJA A;  3UN3 A;  4MIV A;  1AJB A;  3NKQ A;  2GA3 A;  1ZEF A;  3A52 A;  4QAX A;  1O99 A;  4UPL A;  4ZG6 A;  3IGZ B;  4LRC A;  1KH5 A;  1SHQ A;  2IUC A;  3ED4 A;  3SZY A;  4LRA A;  1KHL A;  2D1G A;  4KAV A;  4TN0 A;  5GOV A;  2GSN A;  3BDG B;  3M7V A;  3DPC A;  1ANJ A;  4UPI A;  3Q3Q A;  1N2L A;  4MY4 A;  1E2S P;  1E33 P;  1EW2 A;  1P49 A;  2W5S A;  1KHK A;  2W8S A;  1SHN A;  5TJ3 A;  3NKN A;  3E2D A;  3CMR A;  2X98 A;  1FSU A;  3B5Q A;  4CXK A;  3WAX A;  2W5W A;  3M8Z A;  4LQY A;  1ALI A;  2ZKT A;  1KH4 A;  1EQJ A;  1E1Z P;  1EW8 A;  3UN5 A;  1AJC A;  2QZU A;  1EW9 A;  5EGH A;  1HDH A;  3KD8 A;  2W5X A;  3BDG A;  1KHN A;  4YR1 A;  5IJS A;  1KH7 A;  1Y6V A;  1ELZ A;  3NKO A;  1ED9 A;  3OT9 A;  1EI6 A;  2GLQ A;  4KJD A;  2W5V A;  5LRM A;  1O98 A;  5DLT A;  2W8D A;  3T01 A;  4UOP A;  4GTY A;  4KM4 A;  1K7H A;  2RH6 A;  4CYR A;  2W5T A;  2ANH A;  3M8Y A;  2VQR A;  1ELX A;  3TWZ A;  5L0K A;  1ALK A;  1KHJ A;  1ED8 A;  4NWX A;  5LQQ A;  4FDJ A;  1ELY A;  3BDF A;  4LR9 A;  3T00 A;  5GRR A;  5LIA A;  3MK1 A;  4KAY A;  4LRF A;  3T02 A;  5C66 A;  1Y7A A;  1HJK A;  4LRB A;  3LXQ A;  1KH9 A;  3WAV A;  1HQA A;  4CXS A;  2XR9 A;  4UPH A;  4KJG A;  3WAW A;  3UNY A;  3NKM A;  3NVL A;  3NKP A;  1AJD A;  4N7T A;  2XRG A;  4CXU A;  4FDI A;  3TX0 A;  1URA A;  4MHX A;  1ALH A;  4ZGA A;  4ZG7 A;  1URB A;  3NKR A;  4UOO A;  3IDD A;  3UO0 A;  5DLW A;  4GTZ A;  4CYS A;  5L0B A;  2W5Q A;  4ZG9 A;  3MK0 A;  2G9Y A;  3BDH A;  4LR8 A; 
#chains in the Genus database with same CATH topology
 4LRD A;  2GSO A;  4LR7 A;  5INH A;  5DLV A;  2IFY A;  3IGY B;  3WAY A;  1E3C P;  1N2K A;  4NWJ A;  2IUC B;  5EGE A;  4LR2 A;  3UN2 A;  3TG0 A;  5L0E A;  5AJ9 A;  1AUK A;  2GSU A;  3M8W A;  4UOR A;  4UPK A;  4GTX A;  5K4P A;  1ZED A;  1EJJ A;  2W5R A;  5LRN A;  4B56 A;  4LRE A;  4GTW A;  5IJQ A;  5KXA A;  1ANI A;  5HRT A;  1B8J A;  3WBH A;  1ZEB A;  3MK2 A;  1ALJ A;  3DYC A;  3SZZ A;  1AJA A;  3UN3 A;  4MIV A;  1AJB A;  3NKQ A;  2GA3 A;  1ZEF A;  3A52 A;  4QAX A;  1O99 A;  4UPL A;  4ZG6 A;  3IGZ B;  4LRC A;  1KH5 A;  1SHQ A;  2IUC A;  3ED4 A;  3SZY A;  4LRA A;  1KHL A;  2D1G A;  4KAV A;  4TN0 A;  5GOV A;  2GSN A;  3BDG B;  3M7V A;  3DPC A;  1ANJ A;  4UPI A;  3Q3Q A;  1N2L A;  4MY4 A;  1E2S P;  1E33 P;  1EW2 A;  1P49 A;  2W5S A;  1KHK A;  2W8S A;  1SHN A;  5TJ3 A;  3NKN A;  3E2D A;  3CMR A;  2X98 A;  1FSU A;  3B5Q A;  4CXK A;  3WAX A;  2W5W A;  3M8Z A;  4LQY A;  1ALI A;  2ZKT A;  1KH4 A;  1EQJ A;  1E1Z P;  1EW8 A;  3UN5 A;  1AJC A;  2QZU A;  1EW9 A;  5EGH A;  1HDH A;  3KD8 A;  2W5X A;  3BDG A;  1KHN A;  4YR1 A;  5IJS A;  1KH7 A;  1Y6V A;  1ELZ A;  3NKO A;  1ED9 A;  3OT9 A;  1EI6 A;  2GLQ A;  4KJD A;  2W5V A;  5LRM A;  1O98 A;  5DLT A;  2W8D A;  3T01 A;  4UOP A;  4GTY A;  4KM4 A;  1K7H A;  2RH6 A;  4CYR A;  2W5T A;  2ANH A;  3M8Y A;  2VQR A;  1ELX A;  3TWZ A;  5L0K A;  1ALK A;  1KHJ A;  1ED8 A;  4NWX A;  5LQQ A;  4FDJ A;  1ELY A;  3BDF A;  4LR9 A;  3T00 A;  5GRR A;  5LIA A;  3MK1 A;  4KAY A;  4LRF A;  3T02 A;  5C66 A;  1Y7A A;  1HJK A;  4LRB A;  3LXQ A;  1KH9 A;  3WAV A;  1HQA A;  4CXS A;  2XR9 A;  4UPH A;  4KJG A;  3WAW A;  3UNY A;  3NKM A;  3NVL A;  3NKP A;  1AJD A;  4N7T A;  2XRG A;  4CXU A;  4FDI A;  3TX0 A;  1URA A;  4MHX A;  1ALH A;  4ZGA A;  4ZG7 A;  1URB A;  3NKR A;  4UOO A;  3IDD A;  3UO0 A;  5DLW A;  4GTZ A;  4CYS A;  5L0B A;  2W5Q A;  4ZG9 A;  3MK0 A;  2G9Y A;  3BDH A;  4LR8 A; 
#chains in the Genus database with same CATH homology
 4LRD A;  2GSO A;  4LR7 A;  5INH A;  5DLV A;  2IFY A;  3IGY B;  3WAY A;  1E3C P;  1N2K A;  4NWJ A;  2IUC B;  5EGE A;  4LR2 A;  3UN2 A;  3TG0 A;  5L0E A;  5AJ9 A;  1AUK A;  2GSU A;  3M8W A;  4UOR A;  4UPK A;  4GTX A;  5K4P A;  1ZED A;  1EJJ A;  2W5R A;  5LRN A;  4B56 A;  4LRE A;  4GTW A;  5IJQ A;  5KXA A;  1ANI A;  5HRT A;  1B8J A;  3WBH A;  1ZEB A;  3MK2 A;  1ALJ A;  3DYC A;  3SZZ A;  1AJA A;  3UN3 A;  4MIV A;  1AJB A;  3NKQ A;  2GA3 A;  1ZEF A;  3A52 A;  4QAX A;  1O99 A;  4UPL A;  4ZG6 A;  3IGZ B;  4LRC A;  1KH5 A;  1SHQ A;  2IUC A;  3ED4 A;  3SZY A;  4LRA A;  1KHL A;  2D1G A;  4KAV A;  4TN0 A;  5GOV A;  2GSN A;  3BDG B;  3M7V A;  3DPC A;  1ANJ A;  4UPI A;  3Q3Q A;  1N2L A;  4MY4 A;  1E2S P;  1E33 P;  1EW2 A;  1P49 A;  2W5S A;  1KHK A;  2W8S A;  1SHN A;  5TJ3 A;  3NKN A;  3E2D A;  3CMR A;  2X98 A;  1FSU A;  3B5Q A;  4CXK A;  3WAX A;  2W5W A;  3M8Z A;  4LQY A;  1ALI A;  2ZKT A;  1KH4 A;  1EQJ A;  1E1Z P;  1EW8 A;  3UN5 A;  1AJC A;  2QZU A;  1EW9 A;  5EGH A;  1HDH A;  3KD8 A;  2W5X A;  3BDG A;  1KHN A;  4YR1 A;  5IJS A;  1KH7 A;  1Y6V A;  1ELZ A;  3NKO A;  1ED9 A;  3OT9 A;  1EI6 A;  2GLQ A;  4KJD A;  2W5V A;  5LRM A;  1O98 A;  5DLT A;  2W8D A;  3T01 A;  4UOP A;  4GTY A;  4KM4 A;  1K7H A;  2RH6 A;  4CYR A;  2W5T A;  2ANH A;  3M8Y A;  2VQR A;  1ELX A;  3TWZ A;  5L0K A;  1ALK A;  1KHJ A;  1ED8 A;  4NWX A;  5LQQ A;  4FDJ A;  1ELY A;  3BDF A;  4LR9 A;  3T00 A;  5GRR A;  5LIA A;  3MK1 A;  4KAY A;  4LRF A;  3T02 A;  5C66 A;  1Y7A A;  1HJK A;  4LRB A;  3LXQ A;  1KH9 A;  3WAV A;  1HQA A;  4CXS A;  2XR9 A;  4UPH A;  4KJG A;  3WAW A;  3UNY A;  3NKM A;  3NVL A;  3NKP A;  1AJD A;  4N7T A;  2XRG A;  4CXU A;  4FDI A;  3TX0 A;  1URA A;  4MHX A;  1ALH A;  4ZGA A;  4ZG7 A;  1URB A;  3NKR A;  4UOO A;  3IDD A;  3UO0 A;  5DLW A;  4GTZ A;  4CYS A;  5L0B A;  2W5Q A;  4ZG9 A;  3MK0 A;  2G9Y A;  3BDH A;  4LR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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