1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
3BDGA 1ANJA 1ED9A 1SHQA 5TJ3A 3WAXA 1ZEFA 3TX0A 1HQAA 1O98A 1AJAA 2GLQA 4ZG6A 4NWXA 3NVLA 2ZKTA 3E2DA 2W5TA 4KAYA 4ZGAA 1EQJA 3BDFA 2IUCB 1EJJA 1EW8A 4LQYA 3WAVA 4CXKA 3UN2A 1Y7AA 5DLVA 5HRTA 1EI6A 2RH6A 1URBA 4GTXA 3M8ZA 3M8WA 3TWZA 3MK0A 2W5SA 4UPHA 1ALHA 4UPLA 4FDJA 5L0KA 1E33P 4QAXA 2GSOA 3MK2A 1EW2A 1N2KA 1Y6VA 3OT9A 4GTZA 5DLWA 4KAVA 2GSNA 4LRCA 1ZEDA 4TN0A 5LRMA 1KHJA 4UOOA 3WAWA 1HDHA 3NKQA 3WAYA 1KH4A 1P49A 4CYRA 4N7TA 5GRRA 5EGHA 5LQQA 3TG0A 3DYCA 1HJKA 5KXAA 4LRFA 4UOPA 1FSUA 1KH9A 5GOVA 1ED8A 1E1ZP 3NKOA 1E3CP 2D1GA 3SZYA 3M7VA 4B56A 5C66A 2IFYA 2IUCA 4NWJA 5EGEA 1URAA 5AJ9A 1ALJA 1AJBA 3DPCA 2X98A 4LREA 2W5XA 3NKMA 3UN5A 5L0EA 2VQRA 4ZG9A 1KHKA 2GSUA 1ANIA 3NKPA 1ALIA 1AJCA 2W5QA 1N2LA 3KD8A 4MHXA 4LRAA 3CMRA 1KH7A 1O99A 4LRBA 3UN3A 4LR2A 4LR7A 4LRDA 3IGZB 1B8JA 1ELYA 2W5RA 1SHNA 2W5WA 1ALKA 1KHLA 4UORA 2XRGA 1E2SP 1AJDA 3T02A 3NKRA 4LR9A 1KH5A 4KM4A 3T01A 2W8DA 1ELZA 3BDGB 5L0BA 3IDDA 4CXSA 3A52A 4KJGA 2QZUA 1EW9A 3B5QA 1ELXA 4LR8A 4UPKA 5K4PA 4UPIA 4ZG7A 5IJSA 2W8SA 1KHNA 3SZZA 5LIAA 1K7HA 4FDIA 3UNYA 3UO0A 1AUKA 4KJDA 4GTWA 2ANHA 4GTYA 5IJQA 4CXUA 2GA3A 3BDHA 3T00A 1ZEBA 2G9YA 4CYSA 4YR1A 3M8YA 3NKNA 3Q3QA 5LRNA 4MIVA 3MK1A 5DLTA 3LXQA 5INHA 3WBHA 4MY4A 3IGYB 2W5VA 2XR9A 3ED4A
chains in the Genus database with same CATH superfamily
3BDGA 1ANJA 1ED9A 1SHQA 5TJ3A 3WAXA 1ZEFA 3TX0A 1HQAA 1O98A 1AJAA 2GLQA 4ZG6A 4NWXA 3NVLA 2ZKTA 3E2DA 2W5TA 4KAYA 4ZGAA 1EQJA 3BDFA 2IUCB 1EJJA 1EW8A 4LQYA 3WAVA 4CXKA 3UN2A 1Y7AA 5DLVA 5HRTA 1EI6A 2RH6A 1URBA 4GTXA 3M8ZA 3M8WA 3TWZA 3MK0A 2W5SA 4UPHA 1ALHA 4UPLA 4FDJA 5L0KA 1E33P 4QAXA 2GSOA 3MK2A 1EW2A 1N2KA 1Y6VA 3OT9A 4GTZA 5DLWA 4KAVA 2GSNA 4LRCA 1ZEDA 4TN0A 5LRMA 1KHJA 4UOOA 3WAWA 1HDHA 3NKQA 3WAYA 1KH4A 1P49A 4CYRA 4N7TA 5GRRA 5EGHA 5LQQA 3TG0A 3DYCA 1HJKA 5KXAA 4LRFA 4UOPA 1FSUA 1KH9A 5GOVA 1ED8A 1E1ZP 3NKOA 1E3CP 2D1GA 3SZYA 3M7VA 4B56A 5C66A 2IFYA 2IUCA 4NWJA 5EGEA 1URAA 5AJ9A 1ALJA 1AJBA 3DPCA 2X98A 4LREA 2W5XA 3NKMA 3UN5A 5L0EA 2VQRA 4ZG9A 1KHKA 2GSUA 1ANIA 3NKPA 1ALIA 1AJCA 2W5QA 1N2LA 3KD8A 4MHXA 4LRAA 3CMRA 1KH7A 1O99A 4LRBA 3UN3A 4LR2A 4LR7A 4LRDA 3IGZB 1B8JA 1ELYA 2W5RA 1SHNA 2W5WA 1ALKA 1KHLA 4UORA 2XRGA 1E2SP 1AJDA 3T02A 3NKRA 4LR9A 1KH5A 4KM4A 3T01A 2W8DA 1ELZA 3BDGB 5L0BA 3IDDA 4CXSA 3A52A 4KJGA 2QZUA 1EW9A 3B5QA 1ELXA 4LR8A 4UPKA 5K4PA 4UPIA 4ZG7A 5IJSA 2W8SA 1KHNA 3SZZA 5LIAA 1K7HA 4FDIA 3UNYA 3UO0A 1AUKA 4KJDA 4GTWA 2ANHA 4GTYA 5IJQA 4CXUA 2GA3A 3BDHA 3T00A 1ZEBA 2G9YA 4CYSA 4YR1A 3M8YA 3NKNA 3Q3QA 5LRNA 4MIVA 3MK1A 5DLTA 3LXQA 5INHA 3WBHA 4MY4A 3IGYB 2W5VA 2XR9A 3ED4A
chains in the Genus database with same CATH topology
3BDGA 1ANJA 1ED9A 1SHQA 5TJ3A 3WAXA 1ZEFA 3TX0A 1HQAA 1O98A 1AJAA 2GLQA 4ZG6A 4NWXA 3NVLA 2ZKTA 3E2DA 2W5TA 4KAYA 4ZGAA 1EQJA 3BDFA 2IUCB 1EJJA 1EW8A 4LQYA 3WAVA 4CXKA 3UN2A 1Y7AA 5DLVA 5HRTA 1EI6A 2RH6A 1URBA 4GTXA 3M8ZA 3M8WA 3TWZA 3MK0A 2W5SA 4UPHA 1ALHA 4UPLA 4FDJA 5L0KA 1E33P 4QAXA 2GSOA 3MK2A 1EW2A 1N2KA 1Y6VA 3OT9A 4GTZA 5DLWA 4KAVA 2GSNA 4LRCA 1ZEDA 4TN0A 5LRMA 1KHJA 4UOOA 3WAWA 1HDHA 3NKQA 3WAYA 1KH4A 1P49A 4CYRA 4N7TA 5GRRA 5EGHA 5LQQA 3TG0A 3DYCA 1HJKA 5KXAA 4LRFA 4UOPA 1FSUA 1KH9A 5GOVA 1ED8A 1E1ZP 3NKOA 1E3CP 2D1GA 3SZYA 3M7VA 4B56A 5C66A 2IFYA 2IUCA 4NWJA 5EGEA 1URAA 5AJ9A 1ALJA 1AJBA 3DPCA 2X98A 4LREA 2W5XA 3NKMA 3UN5A 5L0EA 2VQRA 4ZG9A 1KHKA 2GSUA 1ANIA 3NKPA 1ALIA 1AJCA 2W5QA 1N2LA 3KD8A 4MHXA 4LRAA 3CMRA 1KH7A 1O99A 4LRBA 3UN3A 4LR2A 4LR7A 4LRDA 3IGZB 1B8JA 1ELYA 2W5RA 1SHNA 2W5WA 1ALKA 1KHLA 4UORA 2XRGA 1E2SP 1AJDA 3T02A 3NKRA 4LR9A 1KH5A 4KM4A 3T01A 2W8DA 1ELZA 3BDGB 5L0BA 3IDDA 4CXSA 3A52A 4KJGA 2QZUA 1EW9A 3B5QA 1ELXA 4LR8A 4UPKA 5K4PA 4UPIA 4ZG7A 5IJSA 2W8SA 1KHNA 3SZZA 5LIAA 1K7HA 4FDIA 3UNYA 3UO0A 1AUKA 4KJDA 4GTWA 2ANHA 4GTYA 5IJQA 4CXUA 2GA3A 3BDHA 3T00A 1ZEBA 2G9YA 4CYSA 4YR1A 3M8YA 3NKNA 3Q3QA 5LRNA 4MIVA 3MK1A 5DLTA 3LXQA 5INHA 3WBHA 4MY4A 3IGYB 2W5VA 2XR9A 3ED4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDG A;  1ANJ A;  1ED9 A;  1SHQ A;  5TJ3 A;  3WAX A;  1ZEF A;  3TX0 A;  1HQA A;  1O98 A;  1AJA A;  2GLQ A;  4ZG6 A;  4NWX A;  3NVL A;  2ZKT A;  3E2D A;  2W5T A;  4KAY A;  4ZGA A;  1EQJ A;  3BDF A;  2IUC B;  1EJJ A;  1EW8 A;  4LQY A;  3WAV A;  4CXK A;  3UN2 A;  1Y7A A;  5DLV A;  5HRT A;  1EI6 A;  2RH6 A;  1URB A;  4GTX A;  3M8Z A;  3M8W A;  3TWZ A;  3MK0 A;  2W5S A;  4UPH A;  1ALH A;  4UPL A;  4FDJ A;  5L0K A;  1E33 P;  4QAX A;  2GSO A;  3MK2 A;  1EW2 A;  1N2K A;  1Y6V A;  3OT9 A;  4GTZ A;  5DLW A;  4KAV A;  2GSN A;  4LRC A;  1ZED A;  4TN0 A;  5LRM A;  1KHJ A;  4UOO A;  3WAW A;  1HDH A;  3NKQ A;  3WAY A;  1KH4 A;  1P49 A;  4CYR A;  4N7T A;  5GRR A;  5EGH A;  5LQQ A;  3TG0 A;  3DYC A;  1HJK A;  5KXA A;  4LRF A;  4UOP A;  1FSU A;  1KH9 A;  5GOV A;  1ED8 A;  1E1Z P;  3NKO A;  1E3C P;  2D1G A;  3SZY A;  3M7V A;  4B56 A;  5C66 A;  2IFY A;  2IUC A;  4NWJ A;  5EGE A;  1URA A;  5AJ9 A;  1ALJ A;  1AJB A;  3DPC A;  2X98 A;  4LRE A;  2W5X A;  3NKM A;  3UN5 A;  5L0E A;  2VQR A;  4ZG9 A;  1KHK A;  2GSU A;  1ANI A;  3NKP A;  1ALI A;  1AJC A;  2W5Q A;  1N2L A;  3KD8 A;  4MHX A;  4LRA A;  3CMR A;  1KH7 A;  1O99 A;  4LRB A;  3UN3 A;  4LR2 A;  4LR7 A;  4LRD A;  3IGZ B;  1B8J A;  1ELY A;  2W5R A;  1SHN A;  2W5W A;  1ALK A;  1KHL A;  4UOR A;  2XRG A;  1E2S P;  1AJD A;  3T02 A;  3NKR A;  4LR9 A;  1KH5 A;  4KM4 A;  3T01 A;  2W8D A;  1ELZ A;  3BDG B;  5L0B A;  3IDD A;  4CXS A;  3A52 A;  4KJG A;  2QZU A;  1EW9 A;  3B5Q A;  1ELX A;  4LR8 A;  4UPK A;  5K4P A;  4UPI A;  4ZG7 A;  5IJS A;  2W8S A;  1KHN A;  3SZZ A;  5LIA A;  1K7H A;  4FDI A;  3UNY A;  3UO0 A;  1AUK A;  4KJD A;  4GTW A;  2ANH A;  4GTY A;  5IJQ A;  4CXU A;  2GA3 A;  3BDH A;  3T00 A;  1ZEB A;  2G9Y A;  4CYS A;  4YR1 A;  3M8Y A;  3NKN A;  3Q3Q A;  5LRN A;  4MIV A;  3MK1 A;  5DLT A;  3LXQ A;  5INH A;  3WBH A;  4MY4 A;  3IGY B;  2W5V A;  2XR9 A;  3ED4 A; 
#chains in the Genus database with same CATH topology
 3BDG A;  1ANJ A;  1ED9 A;  1SHQ A;  5TJ3 A;  3WAX A;  1ZEF A;  3TX0 A;  1HQA A;  1O98 A;  1AJA A;  2GLQ A;  4ZG6 A;  4NWX A;  3NVL A;  2ZKT A;  3E2D A;  2W5T A;  4KAY A;  4ZGA A;  1EQJ A;  3BDF A;  2IUC B;  1EJJ A;  1EW8 A;  4LQY A;  3WAV A;  4CXK A;  3UN2 A;  1Y7A A;  5DLV A;  5HRT A;  1EI6 A;  2RH6 A;  1URB A;  4GTX A;  3M8Z A;  3M8W A;  3TWZ A;  3MK0 A;  2W5S A;  4UPH A;  1ALH A;  4UPL A;  4FDJ A;  5L0K A;  1E33 P;  4QAX A;  2GSO A;  3MK2 A;  1EW2 A;  1N2K A;  1Y6V A;  3OT9 A;  4GTZ A;  5DLW A;  4KAV A;  2GSN A;  4LRC A;  1ZED A;  4TN0 A;  5LRM A;  1KHJ A;  4UOO A;  3WAW A;  1HDH A;  3NKQ A;  3WAY A;  1KH4 A;  1P49 A;  4CYR A;  4N7T A;  5GRR A;  5EGH A;  5LQQ A;  3TG0 A;  3DYC A;  1HJK A;  5KXA A;  4LRF A;  4UOP A;  1FSU A;  1KH9 A;  5GOV A;  1ED8 A;  1E1Z P;  3NKO A;  1E3C P;  2D1G A;  3SZY A;  3M7V A;  4B56 A;  5C66 A;  2IFY A;  2IUC A;  4NWJ A;  5EGE A;  1URA A;  5AJ9 A;  1ALJ A;  1AJB A;  3DPC A;  2X98 A;  4LRE A;  2W5X A;  3NKM A;  3UN5 A;  5L0E A;  2VQR A;  4ZG9 A;  1KHK A;  2GSU A;  1ANI A;  3NKP A;  1ALI A;  1AJC A;  2W5Q A;  1N2L A;  3KD8 A;  4MHX A;  4LRA A;  3CMR A;  1KH7 A;  1O99 A;  4LRB A;  3UN3 A;  4LR2 A;  4LR7 A;  4LRD A;  3IGZ B;  1B8J A;  1ELY A;  2W5R A;  1SHN A;  2W5W A;  1ALK A;  1KHL A;  4UOR A;  2XRG A;  1E2S P;  1AJD A;  3T02 A;  3NKR A;  4LR9 A;  1KH5 A;  4KM4 A;  3T01 A;  2W8D A;  1ELZ A;  3BDG B;  5L0B A;  3IDD A;  4CXS A;  3A52 A;  4KJG A;  2QZU A;  1EW9 A;  3B5Q A;  1ELX A;  4LR8 A;  4UPK A;  5K4P A;  4UPI A;  4ZG7 A;  5IJS A;  2W8S A;  1KHN A;  3SZZ A;  5LIA A;  1K7H A;  4FDI A;  3UNY A;  3UO0 A;  1AUK A;  4KJD A;  4GTW A;  2ANH A;  4GTY A;  5IJQ A;  4CXU A;  2GA3 A;  3BDH A;  3T00 A;  1ZEB A;  2G9Y A;  4CYS A;  4YR1 A;  3M8Y A;  3NKN A;  3Q3Q A;  5LRN A;  4MIV A;  3MK1 A;  5DLT A;  3LXQ A;  5INH A;  3WBH A;  4MY4 A;  3IGY B;  2W5V A;  2XR9 A;  3ED4 A; 
#chains in the Genus database with same CATH homology
 3BDG A;  1ANJ A;  1ED9 A;  1SHQ A;  5TJ3 A;  3WAX A;  1ZEF A;  3TX0 A;  1HQA A;  1O98 A;  1AJA A;  2GLQ A;  4ZG6 A;  4NWX A;  3NVL A;  2ZKT A;  3E2D A;  2W5T A;  4KAY A;  4ZGA A;  1EQJ A;  3BDF A;  2IUC B;  1EJJ A;  1EW8 A;  4LQY A;  3WAV A;  4CXK A;  3UN2 A;  1Y7A A;  5DLV A;  5HRT A;  1EI6 A;  2RH6 A;  1URB A;  4GTX A;  3M8Z A;  3M8W A;  3TWZ A;  3MK0 A;  2W5S A;  4UPH A;  1ALH A;  4UPL A;  4FDJ A;  5L0K A;  1E33 P;  4QAX A;  2GSO A;  3MK2 A;  1EW2 A;  1N2K A;  1Y6V A;  3OT9 A;  4GTZ A;  5DLW A;  4KAV A;  2GSN A;  4LRC A;  1ZED A;  4TN0 A;  5LRM A;  1KHJ A;  4UOO A;  3WAW A;  1HDH A;  3NKQ A;  3WAY A;  1KH4 A;  1P49 A;  4CYR A;  4N7T A;  5GRR A;  5EGH A;  5LQQ A;  3TG0 A;  3DYC A;  1HJK A;  5KXA A;  4LRF A;  4UOP A;  1FSU A;  1KH9 A;  5GOV A;  1ED8 A;  1E1Z P;  3NKO A;  1E3C P;  2D1G A;  3SZY A;  3M7V A;  4B56 A;  5C66 A;  2IFY A;  2IUC A;  4NWJ A;  5EGE A;  1URA A;  5AJ9 A;  1ALJ A;  1AJB A;  3DPC A;  2X98 A;  4LRE A;  2W5X A;  3NKM A;  3UN5 A;  5L0E A;  2VQR A;  4ZG9 A;  1KHK A;  2GSU A;  1ANI A;  3NKP A;  1ALI A;  1AJC A;  2W5Q A;  1N2L A;  3KD8 A;  4MHX A;  4LRA A;  3CMR A;  1KH7 A;  1O99 A;  4LRB A;  3UN3 A;  4LR2 A;  4LR7 A;  4LRD A;  3IGZ B;  1B8J A;  1ELY A;  2W5R A;  1SHN A;  2W5W A;  1ALK A;  1KHL A;  4UOR A;  2XRG A;  1E2S P;  1AJD A;  3T02 A;  3NKR A;  4LR9 A;  1KH5 A;  4KM4 A;  3T01 A;  2W8D A;  1ELZ A;  3BDG B;  5L0B A;  3IDD A;  4CXS A;  3A52 A;  4KJG A;  2QZU A;  1EW9 A;  3B5Q A;  1ELX A;  4LR8 A;  4UPK A;  5K4P A;  4UPI A;  4ZG7 A;  5IJS A;  2W8S A;  1KHN A;  3SZZ A;  5LIA A;  1K7H A;  4FDI A;  3UNY A;  3UO0 A;  1AUK A;  4KJD A;  4GTW A;  2ANH A;  4GTY A;  5IJQ A;  4CXU A;  2GA3 A;  3BDH A;  3T00 A;  1ZEB A;  2G9Y A;  4CYS A;  4YR1 A;  3M8Y A;  3NKN A;  3Q3Q A;  5LRN A;  4MIV A;  3MK1 A;  5DLT A;  3LXQ A;  5INH A;  3WBH A;  4MY4 A;  3IGY B;  2W5V A;  2XR9 A;  3ED4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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