1HQAA

Alkaline phosphatase (h412q)
Total Genus 161
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEQTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase (alkaline phosphatase)
molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
pubmed doi rcsb
source organism Escherichia coli
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hqaA00
1AUKA 5DLTA 4LRFA 1ANIA 2X98A 1HQAA 1EQJA 1Y7AA 3IDDA 3IGZB 3ED4A 4GTZA 4KJDA 4LRCA 1KHKA 3UO0A 2XR9A 1HDHA 4LRDA 5IJQA 3WAVA 1E33P 4UOPA 3WAXA 1AJBA 5LQQA 1O98A 1ED8A 4ZG9A 4LR2A 3BDHA 3A52A 3E2DA 3M8WA 4N7TA 1ZEDA 2VQRA 1ALHA 3BDGA 3NKNA 2GSUA 5HRTA 5IJSA 3TG0A 4KM4A 3UN2A 3NVLA 4LRAA 4LR9A 3M7VA 3UNYA 5KXAA 3M8ZA 3TWZA 1O99A 2GSOA 4B56A 3T02A 4UPLA 1SHQA 1ELXA 3DYCA 4CYRA 1KH5A 4LRBA 1SHNA 5TJ3A 1E1ZP 2W8DA 3T00A 2W5RA 4ZG7A 4CXSA 3NKQA 4MY4A 2IUCB 1EW8A 4KAYA 1ZEFA 4KAVA 5GOVA 3UN3A 1B8JA 1ELZA 4YR1A 5LIAA 3KD8A 3NKPA 2W5QA 1N2KA 3IGYB 5AJ9A 3NKOA 3DPCA 1EW2A 3M8YA 2W5SA 4UOOA 3UN5A 4UPIA 3NKMA 3Q3QA 3T01A 1HJKA 2W5TA 2GA3A 3TX0A 1KH7A 1ZEBA 1ELYA 3B5QA 3WBHA 4GTYA 4MHXA 2W5XA 4LQYA 2D1GA 2W8SA 4LR7A 5LRMA 2G9YA 1URAA 5L0BA 4CXUA 3BDGB 1EW9A 3CMRA 1KHJA 2ZKTA 1P49A 2XRGA 3MK2A 5L0EA 1URBA 4LR8A 5LRNA 2IFYA 5K4PA 1Y6VA 4GTXA 2W5WA 4NWJA 2GSNA 1FSUA 1AJAA 4NWXA 5GRRA 1EJJA 5INHA 4UPKA 1KH4A 2GLQA 4ZG6A 4UPHA 5L0KA 3MK1A 1E2SP 4UORA 4CXKA 1ALIA 3OT9A 1KHNA 5EGHA 2QZUA 3NKRA 4FDJA 4LREA 1AJDA 1N2LA 3SZYA 1AJCA 3WAYA 3MK0A 4GTWA 1KHLA 3SZZA 5C66A 1ALJA 1ED9A 2ANHA 4QAXA 1ALKA 1K7HA 2RH6A 2W5VA 2IUCA 3WAWA 4KJGA 4MIVA 3BDFA 1KH9A 4ZGAA 4TN0A 1EI6A 1E3CP 4FDIA 5DLWA 5DLVA 1ANJA 5EGEA 4CYSA 3LXQA
chains in the Genus database with same CATH superfamily
1AUKA 5DLTA 4LRFA 1ANIA 2X98A 1HQAA 1EQJA 1Y7AA 3IDDA 3IGZB 3ED4A 4GTZA 4KJDA 4LRCA 1KHKA 3UO0A 2XR9A 1HDHA 4LRDA 5IJQA 3WAVA 1E33P 4UOPA 3WAXA 1AJBA 5LQQA 1O98A 1ED8A 4ZG9A 4LR2A 3BDHA 3A52A 3E2DA 3M8WA 4N7TA 1ZEDA 2VQRA 1ALHA 3BDGA 3NKNA 2GSUA 5HRTA 5IJSA 3TG0A 4KM4A 3UN2A 3NVLA 4LRAA 4LR9A 3M7VA 3UNYA 5KXAA 3M8ZA 3TWZA 1O99A 2GSOA 4B56A 3T02A 4UPLA 1SHQA 1ELXA 3DYCA 4CYRA 1KH5A 4LRBA 1SHNA 5TJ3A 1E1ZP 2W8DA 3T00A 2W5RA 4ZG7A 4CXSA 3NKQA 4MY4A 2IUCB 1EW8A 4KAYA 1ZEFA 4KAVA 5GOVA 3UN3A 1B8JA 1ELZA 4YR1A 5LIAA 3KD8A 3NKPA 2W5QA 1N2KA 3IGYB 5AJ9A 3NKOA 3DPCA 1EW2A 3M8YA 2W5SA 4UOOA 3UN5A 4UPIA 3NKMA 3Q3QA 3T01A 1HJKA 2W5TA 2GA3A 3TX0A 1KH7A 1ZEBA 1ELYA 3B5QA 3WBHA 4GTYA 4MHXA 2W5XA 4LQYA 2D1GA 2W8SA 4LR7A 5LRMA 2G9YA 1URAA 5L0BA 4CXUA 3BDGB 1EW9A 3CMRA 1KHJA 2ZKTA 1P49A 2XRGA 3MK2A 5L0EA 1URBA 4LR8A 5LRNA 2IFYA 5K4PA 1Y6VA 4GTXA 2W5WA 4NWJA 2GSNA 1FSUA 1AJAA 4NWXA 5GRRA 1EJJA 5INHA 4UPKA 1KH4A 2GLQA 4ZG6A 4UPHA 5L0KA 3MK1A 1E2SP 4UORA 4CXKA 1ALIA 3OT9A 1KHNA 5EGHA 2QZUA 3NKRA 4FDJA 4LREA 1AJDA 1N2LA 3SZYA 1AJCA 3WAYA 3MK0A 4GTWA 1KHLA 3SZZA 5C66A 1ALJA 1ED9A 2ANHA 4QAXA 1ALKA 1K7HA 2RH6A 2W5VA 2IUCA 3WAWA 4KJGA 4MIVA 3BDFA 1KH9A 4ZGAA 4TN0A 1EI6A 1E3CP 4FDIA 5DLWA 5DLVA 1ANJA 5EGEA 4CYSA 3LXQA
chains in the Genus database with same CATH topology
1AUKA 5DLTA 4LRFA 1ANIA 2X98A 1HQAA 1EQJA 1Y7AA 3IDDA 3IGZB 3ED4A 4GTZA 4KJDA 4LRCA 1KHKA 3UO0A 2XR9A 1HDHA 4LRDA 5IJQA 3WAVA 1E33P 4UOPA 3WAXA 1AJBA 5LQQA 1O98A 1ED8A 4ZG9A 4LR2A 3BDHA 3A52A 3E2DA 3M8WA 4N7TA 1ZEDA 2VQRA 1ALHA 3BDGA 3NKNA 2GSUA 5HRTA 5IJSA 3TG0A 4KM4A 3UN2A 3NVLA 4LRAA 4LR9A 3M7VA 3UNYA 5KXAA 3M8ZA 3TWZA 1O99A 2GSOA 4B56A 3T02A 4UPLA 1SHQA 1ELXA 3DYCA 4CYRA 1KH5A 4LRBA 1SHNA 5TJ3A 1E1ZP 2W8DA 3T00A 2W5RA 4ZG7A 4CXSA 3NKQA 4MY4A 2IUCB 1EW8A 4KAYA 1ZEFA 4KAVA 5GOVA 3UN3A 1B8JA 1ELZA 4YR1A 5LIAA 3KD8A 3NKPA 2W5QA 1N2KA 3IGYB 5AJ9A 3NKOA 3DPCA 1EW2A 3M8YA 2W5SA 4UOOA 3UN5A 4UPIA 3NKMA 3Q3QA 3T01A 1HJKA 2W5TA 2GA3A 3TX0A 1KH7A 1ZEBA 1ELYA 3B5QA 3WBHA 4GTYA 4MHXA 2W5XA 4LQYA 2D1GA 2W8SA 4LR7A 5LRMA 2G9YA 1URAA 5L0BA 4CXUA 3BDGB 1EW9A 3CMRA 1KHJA 2ZKTA 1P49A 2XRGA 3MK2A 5L0EA 1URBA 4LR8A 5LRNA 2IFYA 5K4PA 1Y6VA 4GTXA 2W5WA 4NWJA 2GSNA 1FSUA 1AJAA 4NWXA 5GRRA 1EJJA 5INHA 4UPKA 1KH4A 2GLQA 4ZG6A 4UPHA 5L0KA 3MK1A 1E2SP 4UORA 4CXKA 1ALIA 3OT9A 1KHNA 5EGHA 2QZUA 3NKRA 4FDJA 4LREA 1AJDA 1N2LA 3SZYA 1AJCA 3WAYA 3MK0A 4GTWA 1KHLA 3SZZA 5C66A 1ALJA 1ED9A 2ANHA 4QAXA 1ALKA 1K7HA 2RH6A 2W5VA 2IUCA 3WAWA 4KJGA 4MIVA 3BDFA 1KH9A 4ZGAA 4TN0A 1EI6A 1E3CP 4FDIA 5DLWA 5DLVA 1ANJA 5EGEA 4CYSA 3LXQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AUK A;  5DLT A;  4LRF A;  1ANI A;  2X98 A;  1HQA A;  1EQJ A;  1Y7A A;  3IDD A;  3IGZ B;  3ED4 A;  4GTZ A;  4KJD A;  4LRC A;  1KHK A;  3UO0 A;  2XR9 A;  1HDH A;  4LRD A;  5IJQ A;  3WAV A;  1E33 P;  4UOP A;  3WAX A;  1AJB A;  5LQQ A;  1O98 A;  1ED8 A;  4ZG9 A;  4LR2 A;  3BDH A;  3A52 A;  3E2D A;  3M8W A;  4N7T A;  1ZED A;  2VQR A;  1ALH A;  3BDG A;  3NKN A;  2GSU A;  5HRT A;  5IJS A;  3TG0 A;  4KM4 A;  3UN2 A;  3NVL A;  4LRA A;  4LR9 A;  3M7V A;  3UNY A;  5KXA A;  3M8Z A;  3TWZ A;  1O99 A;  2GSO A;  4B56 A;  3T02 A;  4UPL A;  1SHQ A;  1ELX A;  3DYC A;  4CYR A;  1KH5 A;  4LRB A;  1SHN A;  5TJ3 A;  1E1Z P;  2W8D A;  3T00 A;  2W5R A;  4ZG7 A;  4CXS A;  3NKQ A;  4MY4 A;  2IUC B;  1EW8 A;  4KAY A;  1ZEF A;  4KAV A;  5GOV A;  3UN3 A;  1B8J A;  1ELZ A;  4YR1 A;  5LIA A;  3KD8 A;  3NKP A;  2W5Q A;  1N2K A;  3IGY B;  5AJ9 A;  3NKO A;  3DPC A;  1EW2 A;  3M8Y A;  2W5S A;  4UOO A;  3UN5 A;  4UPI A;  3NKM A;  3Q3Q A;  3T01 A;  1HJK A;  2W5T A;  2GA3 A;  3TX0 A;  1KH7 A;  1ZEB A;  1ELY A;  3B5Q A;  3WBH A;  4GTY A;  4MHX A;  2W5X A;  4LQY A;  2D1G A;  2W8S A;  4LR7 A;  5LRM A;  2G9Y A;  1URA A;  5L0B A;  4CXU A;  3BDG B;  1EW9 A;  3CMR A;  1KHJ A;  2ZKT A;  1P49 A;  2XRG A;  3MK2 A;  5L0E A;  1URB A;  4LR8 A;  5LRN A;  2IFY A;  5K4P A;  1Y6V A;  4GTX A;  2W5W A;  4NWJ A;  2GSN A;  1FSU A;  1AJA A;  4NWX A;  5GRR A;  1EJJ A;  5INH A;  4UPK A;  1KH4 A;  2GLQ A;  4ZG6 A;  4UPH A;  5L0K A;  3MK1 A;  1E2S P;  4UOR A;  4CXK A;  1ALI A;  3OT9 A;  1KHN A;  5EGH A;  2QZU A;  3NKR A;  4FDJ A;  4LRE A;  1AJD A;  1N2L A;  3SZY A;  1AJC A;  3WAY A;  3MK0 A;  4GTW A;  1KHL A;  3SZZ A;  5C66 A;  1ALJ A;  1ED9 A;  2ANH A;  4QAX A;  1ALK A;  1K7H A;  2RH6 A;  2W5V A;  2IUC A;  3WAW A;  4KJG A;  4MIV A;  3BDF A;  1KH9 A;  4ZGA A;  4TN0 A;  1EI6 A;  1E3C P;  4FDI A;  5DLW A;  5DLV A;  1ANJ A;  5EGE A;  4CYS A;  3LXQ A; 
#chains in the Genus database with same CATH topology
 1AUK A;  5DLT A;  4LRF A;  1ANI A;  2X98 A;  1HQA A;  1EQJ A;  1Y7A A;  3IDD A;  3IGZ B;  3ED4 A;  4GTZ A;  4KJD A;  4LRC A;  1KHK A;  3UO0 A;  2XR9 A;  1HDH A;  4LRD A;  5IJQ A;  3WAV A;  1E33 P;  4UOP A;  3WAX A;  1AJB A;  5LQQ A;  1O98 A;  1ED8 A;  4ZG9 A;  4LR2 A;  3BDH A;  3A52 A;  3E2D A;  3M8W A;  4N7T A;  1ZED A;  2VQR A;  1ALH A;  3BDG A;  3NKN A;  2GSU A;  5HRT A;  5IJS A;  3TG0 A;  4KM4 A;  3UN2 A;  3NVL A;  4LRA A;  4LR9 A;  3M7V A;  3UNY A;  5KXA A;  3M8Z A;  3TWZ A;  1O99 A;  2GSO A;  4B56 A;  3T02 A;  4UPL A;  1SHQ A;  1ELX A;  3DYC A;  4CYR A;  1KH5 A;  4LRB A;  1SHN A;  5TJ3 A;  1E1Z P;  2W8D A;  3T00 A;  2W5R A;  4ZG7 A;  4CXS A;  3NKQ A;  4MY4 A;  2IUC B;  1EW8 A;  4KAY A;  1ZEF A;  4KAV A;  5GOV A;  3UN3 A;  1B8J A;  1ELZ A;  4YR1 A;  5LIA A;  3KD8 A;  3NKP A;  2W5Q A;  1N2K A;  3IGY B;  5AJ9 A;  3NKO A;  3DPC A;  1EW2 A;  3M8Y A;  2W5S A;  4UOO A;  3UN5 A;  4UPI A;  3NKM A;  3Q3Q A;  3T01 A;  1HJK A;  2W5T A;  2GA3 A;  3TX0 A;  1KH7 A;  1ZEB A;  1ELY A;  3B5Q A;  3WBH A;  4GTY A;  4MHX A;  2W5X A;  4LQY A;  2D1G A;  2W8S A;  4LR7 A;  5LRM A;  2G9Y A;  1URA A;  5L0B A;  4CXU A;  3BDG B;  1EW9 A;  3CMR A;  1KHJ A;  2ZKT A;  1P49 A;  2XRG A;  3MK2 A;  5L0E A;  1URB A;  4LR8 A;  5LRN A;  2IFY A;  5K4P A;  1Y6V A;  4GTX A;  2W5W A;  4NWJ A;  2GSN A;  1FSU A;  1AJA A;  4NWX A;  5GRR A;  1EJJ A;  5INH A;  4UPK A;  1KH4 A;  2GLQ A;  4ZG6 A;  4UPH A;  5L0K A;  3MK1 A;  1E2S P;  4UOR A;  4CXK A;  1ALI A;  3OT9 A;  1KHN A;  5EGH A;  2QZU A;  3NKR A;  4FDJ A;  4LRE A;  1AJD A;  1N2L A;  3SZY A;  1AJC A;  3WAY A;  3MK0 A;  4GTW A;  1KHL A;  3SZZ A;  5C66 A;  1ALJ A;  1ED9 A;  2ANH A;  4QAX A;  1ALK A;  1K7H A;  2RH6 A;  2W5V A;  2IUC A;  3WAW A;  4KJG A;  4MIV A;  3BDF A;  1KH9 A;  4ZGA A;  4TN0 A;  1EI6 A;  1E3C P;  4FDI A;  5DLW A;  5DLV A;  1ANJ A;  5EGE A;  4CYS A;  3LXQ A; 
#chains in the Genus database with same CATH homology
 1AUK A;  5DLT A;  4LRF A;  1ANI A;  2X98 A;  1HQA A;  1EQJ A;  1Y7A A;  3IDD A;  3IGZ B;  3ED4 A;  4GTZ A;  4KJD A;  4LRC A;  1KHK A;  3UO0 A;  2XR9 A;  1HDH A;  4LRD A;  5IJQ A;  3WAV A;  1E33 P;  4UOP A;  3WAX A;  1AJB A;  5LQQ A;  1O98 A;  1ED8 A;  4ZG9 A;  4LR2 A;  3BDH A;  3A52 A;  3E2D A;  3M8W A;  4N7T A;  1ZED A;  2VQR A;  1ALH A;  3BDG A;  3NKN A;  2GSU A;  5HRT A;  5IJS A;  3TG0 A;  4KM4 A;  3UN2 A;  3NVL A;  4LRA A;  4LR9 A;  3M7V A;  3UNY A;  5KXA A;  3M8Z A;  3TWZ A;  1O99 A;  2GSO A;  4B56 A;  3T02 A;  4UPL A;  1SHQ A;  1ELX A;  3DYC A;  4CYR A;  1KH5 A;  4LRB A;  1SHN A;  5TJ3 A;  1E1Z P;  2W8D A;  3T00 A;  2W5R A;  4ZG7 A;  4CXS A;  3NKQ A;  4MY4 A;  2IUC B;  1EW8 A;  4KAY A;  1ZEF A;  4KAV A;  5GOV A;  3UN3 A;  1B8J A;  1ELZ A;  4YR1 A;  5LIA A;  3KD8 A;  3NKP A;  2W5Q A;  1N2K A;  3IGY B;  5AJ9 A;  3NKO A;  3DPC A;  1EW2 A;  3M8Y A;  2W5S A;  4UOO A;  3UN5 A;  4UPI A;  3NKM A;  3Q3Q A;  3T01 A;  1HJK A;  2W5T A;  2GA3 A;  3TX0 A;  1KH7 A;  1ZEB A;  1ELY A;  3B5Q A;  3WBH A;  4GTY A;  4MHX A;  2W5X A;  4LQY A;  2D1G A;  2W8S A;  4LR7 A;  5LRM A;  2G9Y A;  1URA A;  5L0B A;  4CXU A;  3BDG B;  1EW9 A;  3CMR A;  1KHJ A;  2ZKT A;  1P49 A;  2XRG A;  3MK2 A;  5L0E A;  1URB A;  4LR8 A;  5LRN A;  2IFY A;  5K4P A;  1Y6V A;  4GTX A;  2W5W A;  4NWJ A;  2GSN A;  1FSU A;  1AJA A;  4NWX A;  5GRR A;  1EJJ A;  5INH A;  4UPK A;  1KH4 A;  2GLQ A;  4ZG6 A;  4UPH A;  5L0K A;  3MK1 A;  1E2S P;  4UOR A;  4CXK A;  1ALI A;  3OT9 A;  1KHN A;  5EGH A;  2QZU A;  3NKR A;  4FDJ A;  4LRE A;  1AJD A;  1N2L A;  3SZY A;  1AJC A;  3WAY A;  3MK0 A;  4GTW A;  1KHL A;  3SZZ A;  5C66 A;  1ALJ A;  1ED9 A;  2ANH A;  4QAX A;  1ALK A;  1K7H A;  2RH6 A;  2W5V A;  2IUC A;  3WAW A;  4KJG A;  4MIV A;  3BDF A;  1KH9 A;  4ZGA A;  4TN0 A;  1EI6 A;  1E3C P;  4FDI A;  5DLW A;  5DLV A;  1ANJ A;  5EGE A;  4CYS A;  3LXQ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...