1KH4A

E. coli alkaline phosphatase mutant (d330n) in complex with phosphate
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 154
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh4A00
5INHA 1EQJA 2GA3A 1ELXA 1N2LA 2W5WA 5LRMA 2IFYA 1EW9A 1ALIA 2W5VA 2W5QA 2W5RA 3BDHA 2GSOA 4ZG9A 2XRGA 3NKRA 2W5TA 4CYRA 4MIVA 4CXSA 3MK0A 1B8JA 4LRBA 1HQAA 4B56A 2W5SA 5LIAA 2VQRA 1HJKA 4LR7A 3DYCA 4LR8A 4UPHA 1AJDA 3B5QA 4LRFA 2XR9A 5EGEA 4UPLA 3UNYA 3M8YA 1KHNA 2GSUA 1K7HA 4YR1A 4GTZA 4ZGAA 5GRRA 5L0BA 3BDFA 3WAWA 1ED8A 1KH4A 1O99A 1ZEDA 2W8SA 3NVLA 4CYSA 5IJQA 1E3CP 5IJSA 3T02A 3NKNA 4UOPA 1KH9A 3Q3QA 4UPKA 1ZEBA 1HDHA 4ZG7A 5AJ9A 3LXQA 5KXAA 1AJBA 4KAVA 1ALJA 3WAVA 2RH6A 1AUKA 3UN5A 4LRDA 3WBHA 5DLVA 5L0EA 3E2DA 1EI6A 1EJJA 1AJCA 1KHLA 4LR9A 3T01A 3MK2A 2W5XA 4QAXA 4UPIA 1P49A 1ALHA 4KJGA 5EGHA 3OT9A 4LREA 1ELYA 2W8DA 1URBA 3M7VA 1ZEFA 5DLWA 5L0KA 3SZYA 4TN0A 2GLQA 2ANHA 3SZZA 3TX0A 2G9YA 2X98A 4CXUA 1N2KA 5HRTA 3IGYB 1SHQA 4UOOA 1AJAA 3A52A 4GTXA 3UO0A 1E33P 4MY4A 1ED9A 3CMRA 1E1ZP 3NKPA 2IUCA 3M8WA 5K4PA 1URAA 2D1GA 2QZUA 3IGZB 3TG0A 4KM4A 1ANJA 3MK1A 3ED4A 4KJDA 5C66A 2GSNA 5LRNA 1ELZA 3NKMA 4UORA 2IUCB 3M8ZA 1KHJA 3WAXA 4LRCA 1Y6VA 3T00A 5LQQA 1KH5A 3DPCA 4FDIA 4NWJA 3NKOA 5GOVA 3WAYA 3BDGB 4KAYA 1Y7AA 3UN3A 1EW8A 4LR2A 3UN2A 4N7TA 4ZG6A 5DLTA 1O98A 1SHNA 3NKQA 1ANIA 1E2SP 4CXKA 1KHKA 4FDJA 4NWXA 4MHXA 5TJ3A 4GTYA 3TWZA 4LRAA 2ZKTA 1KH7A 4GTWA 4LQYA 3IDDA 1EW2A 1FSUA 3KD8A 1ALKA 3BDGA
chains in the Genus database with same CATH superfamily
5INHA 1EQJA 2GA3A 1ELXA 1N2LA 2W5WA 5LRMA 2IFYA 1EW9A 1ALIA 2W5VA 2W5QA 2W5RA 3BDHA 2GSOA 4ZG9A 2XRGA 3NKRA 2W5TA 4CYRA 4MIVA 4CXSA 3MK0A 1B8JA 4LRBA 1HQAA 4B56A 2W5SA 5LIAA 2VQRA 1HJKA 4LR7A 3DYCA 4LR8A 4UPHA 1AJDA 3B5QA 4LRFA 2XR9A 5EGEA 4UPLA 3UNYA 3M8YA 1KHNA 2GSUA 1K7HA 4YR1A 4GTZA 4ZGAA 5GRRA 5L0BA 3BDFA 3WAWA 1ED8A 1KH4A 1O99A 1ZEDA 2W8SA 3NVLA 4CYSA 5IJQA 1E3CP 5IJSA 3T02A 3NKNA 4UOPA 1KH9A 3Q3QA 4UPKA 1ZEBA 1HDHA 4ZG7A 5AJ9A 3LXQA 5KXAA 1AJBA 4KAVA 1ALJA 3WAVA 2RH6A 1AUKA 3UN5A 4LRDA 3WBHA 5DLVA 5L0EA 3E2DA 1EI6A 1EJJA 1AJCA 1KHLA 4LR9A 3T01A 3MK2A 2W5XA 4QAXA 4UPIA 1P49A 1ALHA 4KJGA 5EGHA 3OT9A 4LREA 1ELYA 2W8DA 1URBA 3M7VA 1ZEFA 5DLWA 5L0KA 3SZYA 4TN0A 2GLQA 2ANHA 3SZZA 3TX0A 2G9YA 2X98A 4CXUA 1N2KA 5HRTA 3IGYB 1SHQA 4UOOA 1AJAA 3A52A 4GTXA 3UO0A 1E33P 4MY4A 1ED9A 3CMRA 1E1ZP 3NKPA 2IUCA 3M8WA 5K4PA 1URAA 2D1GA 2QZUA 3IGZB 3TG0A 4KM4A 1ANJA 3MK1A 3ED4A 4KJDA 5C66A 2GSNA 5LRNA 1ELZA 3NKMA 4UORA 2IUCB 3M8ZA 1KHJA 3WAXA 4LRCA 1Y6VA 3T00A 5LQQA 1KH5A 3DPCA 4FDIA 4NWJA 3NKOA 5GOVA 3WAYA 3BDGB 4KAYA 1Y7AA 3UN3A 1EW8A 4LR2A 3UN2A 4N7TA 4ZG6A 5DLTA 1O98A 1SHNA 3NKQA 1ANIA 1E2SP 4CXKA 1KHKA 4FDJA 4NWXA 4MHXA 5TJ3A 4GTYA 3TWZA 4LRAA 2ZKTA 1KH7A 4GTWA 4LQYA 3IDDA 1EW2A 1FSUA 3KD8A 1ALKA 3BDGA
chains in the Genus database with same CATH topology
5INHA 1EQJA 2GA3A 1ELXA 1N2LA 2W5WA 5LRMA 2IFYA 1EW9A 1ALIA 2W5VA 2W5QA 2W5RA 3BDHA 2GSOA 4ZG9A 2XRGA 3NKRA 2W5TA 4CYRA 4MIVA 4CXSA 3MK0A 1B8JA 4LRBA 1HQAA 4B56A 2W5SA 5LIAA 2VQRA 1HJKA 4LR7A 3DYCA 4LR8A 4UPHA 1AJDA 3B5QA 4LRFA 2XR9A 5EGEA 4UPLA 3UNYA 3M8YA 1KHNA 2GSUA 1K7HA 4YR1A 4GTZA 4ZGAA 5GRRA 5L0BA 3BDFA 3WAWA 1ED8A 1KH4A 1O99A 1ZEDA 2W8SA 3NVLA 4CYSA 5IJQA 1E3CP 5IJSA 3T02A 3NKNA 4UOPA 1KH9A 3Q3QA 4UPKA 1ZEBA 1HDHA 4ZG7A 5AJ9A 3LXQA 5KXAA 1AJBA 4KAVA 1ALJA 3WAVA 2RH6A 1AUKA 3UN5A 4LRDA 3WBHA 5DLVA 5L0EA 3E2DA 1EI6A 1EJJA 1AJCA 1KHLA 4LR9A 3T01A 3MK2A 2W5XA 4QAXA 4UPIA 1P49A 1ALHA 4KJGA 5EGHA 3OT9A 4LREA 1ELYA 2W8DA 1URBA 3M7VA 1ZEFA 5DLWA 5L0KA 3SZYA 4TN0A 2GLQA 2ANHA 3SZZA 3TX0A 2G9YA 2X98A 4CXUA 1N2KA 5HRTA 3IGYB 1SHQA 4UOOA 1AJAA 3A52A 4GTXA 3UO0A 1E33P 4MY4A 1ED9A 3CMRA 1E1ZP 3NKPA 2IUCA 3M8WA 5K4PA 1URAA 2D1GA 2QZUA 3IGZB 3TG0A 4KM4A 1ANJA 3MK1A 3ED4A 4KJDA 5C66A 2GSNA 5LRNA 1ELZA 3NKMA 4UORA 2IUCB 3M8ZA 1KHJA 3WAXA 4LRCA 1Y6VA 3T00A 5LQQA 1KH5A 3DPCA 4FDIA 4NWJA 3NKOA 5GOVA 3WAYA 3BDGB 4KAYA 1Y7AA 3UN3A 1EW8A 4LR2A 3UN2A 4N7TA 4ZG6A 5DLTA 1O98A 1SHNA 3NKQA 1ANIA 1E2SP 4CXKA 1KHKA 4FDJA 4NWXA 4MHXA 5TJ3A 4GTYA 3TWZA 4LRAA 2ZKTA 1KH7A 4GTWA 4LQYA 3IDDA 1EW2A 1FSUA 3KD8A 1ALKA 3BDGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5INH A;  1EQJ A;  2GA3 A;  1ELX A;  1N2L A;  2W5W A;  5LRM A;  2IFY A;  1EW9 A;  1ALI A;  2W5V A;  2W5Q A;  2W5R A;  3BDH A;  2GSO A;  4ZG9 A;  2XRG A;  3NKR A;  2W5T A;  4CYR A;  4MIV A;  4CXS A;  3MK0 A;  1B8J A;  4LRB A;  1HQA A;  4B56 A;  2W5S A;  5LIA A;  2VQR A;  1HJK A;  4LR7 A;  3DYC A;  4LR8 A;  4UPH A;  1AJD A;  3B5Q A;  4LRF A;  2XR9 A;  5EGE A;  4UPL A;  3UNY A;  3M8Y A;  1KHN A;  2GSU A;  1K7H A;  4YR1 A;  4GTZ A;  4ZGA A;  5GRR A;  5L0B A;  3BDF A;  3WAW A;  1ED8 A;  1KH4 A;  1O99 A;  1ZED A;  2W8S A;  3NVL A;  4CYS A;  5IJQ A;  1E3C P;  5IJS A;  3T02 A;  3NKN A;  4UOP A;  1KH9 A;  3Q3Q A;  4UPK A;  1ZEB A;  1HDH A;  4ZG7 A;  5AJ9 A;  3LXQ A;  5KXA A;  1AJB A;  4KAV A;  1ALJ A;  3WAV A;  2RH6 A;  1AUK A;  3UN5 A;  4LRD A;  3WBH A;  5DLV A;  5L0E A;  3E2D A;  1EI6 A;  1EJJ A;  1AJC A;  1KHL A;  4LR9 A;  3T01 A;  3MK2 A;  2W5X A;  4QAX A;  4UPI A;  1P49 A;  1ALH A;  4KJG A;  5EGH A;  3OT9 A;  4LRE A;  1ELY A;  2W8D A;  1URB A;  3M7V A;  1ZEF A;  5DLW A;  5L0K A;  3SZY A;  4TN0 A;  2GLQ A;  2ANH A;  3SZZ A;  3TX0 A;  2G9Y A;  2X98 A;  4CXU A;  1N2K A;  5HRT A;  3IGY B;  1SHQ A;  4UOO A;  1AJA A;  3A52 A;  4GTX A;  3UO0 A;  1E33 P;  4MY4 A;  1ED9 A;  3CMR A;  1E1Z P;  3NKP A;  2IUC A;  3M8W A;  5K4P A;  1URA A;  2D1G A;  2QZU A;  3IGZ B;  3TG0 A;  4KM4 A;  1ANJ A;  3MK1 A;  3ED4 A;  4KJD A;  5C66 A;  2GSN A;  5LRN A;  1ELZ A;  3NKM A;  4UOR A;  2IUC B;  3M8Z A;  1KHJ A;  3WAX A;  4LRC A;  1Y6V A;  3T00 A;  5LQQ A;  1KH5 A;  3DPC A;  4FDI A;  4NWJ A;  3NKO A;  5GOV A;  3WAY A;  3BDG B;  4KAY A;  1Y7A A;  3UN3 A;  1EW8 A;  4LR2 A;  3UN2 A;  4N7T A;  4ZG6 A;  5DLT A;  1O98 A;  1SHN A;  3NKQ A;  1ANI A;  1E2S P;  4CXK A;  1KHK A;  4FDJ A;  4NWX A;  4MHX A;  5TJ3 A;  4GTY A;  3TWZ A;  4LRA A;  2ZKT A;  1KH7 A;  4GTW A;  4LQY A;  3IDD A;  1EW2 A;  1FSU A;  3KD8 A;  1ALK A;  3BDG A; 
#chains in the Genus database with same CATH topology
 5INH A;  1EQJ A;  2GA3 A;  1ELX A;  1N2L A;  2W5W A;  5LRM A;  2IFY A;  1EW9 A;  1ALI A;  2W5V A;  2W5Q A;  2W5R A;  3BDH A;  2GSO A;  4ZG9 A;  2XRG A;  3NKR A;  2W5T A;  4CYR A;  4MIV A;  4CXS A;  3MK0 A;  1B8J A;  4LRB A;  1HQA A;  4B56 A;  2W5S A;  5LIA A;  2VQR A;  1HJK A;  4LR7 A;  3DYC A;  4LR8 A;  4UPH A;  1AJD A;  3B5Q A;  4LRF A;  2XR9 A;  5EGE A;  4UPL A;  3UNY A;  3M8Y A;  1KHN A;  2GSU A;  1K7H A;  4YR1 A;  4GTZ A;  4ZGA A;  5GRR A;  5L0B A;  3BDF A;  3WAW A;  1ED8 A;  1KH4 A;  1O99 A;  1ZED A;  2W8S A;  3NVL A;  4CYS A;  5IJQ A;  1E3C P;  5IJS A;  3T02 A;  3NKN A;  4UOP A;  1KH9 A;  3Q3Q A;  4UPK A;  1ZEB A;  1HDH A;  4ZG7 A;  5AJ9 A;  3LXQ A;  5KXA A;  1AJB A;  4KAV A;  1ALJ A;  3WAV A;  2RH6 A;  1AUK A;  3UN5 A;  4LRD A;  3WBH A;  5DLV A;  5L0E A;  3E2D A;  1EI6 A;  1EJJ A;  1AJC A;  1KHL A;  4LR9 A;  3T01 A;  3MK2 A;  2W5X A;  4QAX A;  4UPI A;  1P49 A;  1ALH A;  4KJG A;  5EGH A;  3OT9 A;  4LRE A;  1ELY A;  2W8D A;  1URB A;  3M7V A;  1ZEF A;  5DLW A;  5L0K A;  3SZY A;  4TN0 A;  2GLQ A;  2ANH A;  3SZZ A;  3TX0 A;  2G9Y A;  2X98 A;  4CXU A;  1N2K A;  5HRT A;  3IGY B;  1SHQ A;  4UOO A;  1AJA A;  3A52 A;  4GTX A;  3UO0 A;  1E33 P;  4MY4 A;  1ED9 A;  3CMR A;  1E1Z P;  3NKP A;  2IUC A;  3M8W A;  5K4P A;  1URA A;  2D1G A;  2QZU A;  3IGZ B;  3TG0 A;  4KM4 A;  1ANJ A;  3MK1 A;  3ED4 A;  4KJD A;  5C66 A;  2GSN A;  5LRN A;  1ELZ A;  3NKM A;  4UOR A;  2IUC B;  3M8Z A;  1KHJ A;  3WAX A;  4LRC A;  1Y6V A;  3T00 A;  5LQQ A;  1KH5 A;  3DPC A;  4FDI A;  4NWJ A;  3NKO A;  5GOV A;  3WAY A;  3BDG B;  4KAY A;  1Y7A A;  3UN3 A;  1EW8 A;  4LR2 A;  3UN2 A;  4N7T A;  4ZG6 A;  5DLT A;  1O98 A;  1SHN A;  3NKQ A;  1ANI A;  1E2S P;  4CXK A;  1KHK A;  4FDJ A;  4NWX A;  4MHX A;  5TJ3 A;  4GTY A;  3TWZ A;  4LRA A;  2ZKT A;  1KH7 A;  4GTW A;  4LQY A;  3IDD A;  1EW2 A;  1FSU A;  3KD8 A;  1ALK A;  3BDG A; 
#chains in the Genus database with same CATH homology
 5INH A;  1EQJ A;  2GA3 A;  1ELX A;  1N2L A;  2W5W A;  5LRM A;  2IFY A;  1EW9 A;  1ALI A;  2W5V A;  2W5Q A;  2W5R A;  3BDH A;  2GSO A;  4ZG9 A;  2XRG A;  3NKR A;  2W5T A;  4CYR A;  4MIV A;  4CXS A;  3MK0 A;  1B8J A;  4LRB A;  1HQA A;  4B56 A;  2W5S A;  5LIA A;  2VQR A;  1HJK A;  4LR7 A;  3DYC A;  4LR8 A;  4UPH A;  1AJD A;  3B5Q A;  4LRF A;  2XR9 A;  5EGE A;  4UPL A;  3UNY A;  3M8Y A;  1KHN A;  2GSU A;  1K7H A;  4YR1 A;  4GTZ A;  4ZGA A;  5GRR A;  5L0B A;  3BDF A;  3WAW A;  1ED8 A;  1KH4 A;  1O99 A;  1ZED A;  2W8S A;  3NVL A;  4CYS A;  5IJQ A;  1E3C P;  5IJS A;  3T02 A;  3NKN A;  4UOP A;  1KH9 A;  3Q3Q A;  4UPK A;  1ZEB A;  1HDH A;  4ZG7 A;  5AJ9 A;  3LXQ A;  5KXA A;  1AJB A;  4KAV A;  1ALJ A;  3WAV A;  2RH6 A;  1AUK A;  3UN5 A;  4LRD A;  3WBH A;  5DLV A;  5L0E A;  3E2D A;  1EI6 A;  1EJJ A;  1AJC A;  1KHL A;  4LR9 A;  3T01 A;  3MK2 A;  2W5X A;  4QAX A;  4UPI A;  1P49 A;  1ALH A;  4KJG A;  5EGH A;  3OT9 A;  4LRE A;  1ELY A;  2W8D A;  1URB A;  3M7V A;  1ZEF A;  5DLW A;  5L0K A;  3SZY A;  4TN0 A;  2GLQ A;  2ANH A;  3SZZ A;  3TX0 A;  2G9Y A;  2X98 A;  4CXU A;  1N2K A;  5HRT A;  3IGY B;  1SHQ A;  4UOO A;  1AJA A;  3A52 A;  4GTX A;  3UO0 A;  1E33 P;  4MY4 A;  1ED9 A;  3CMR A;  1E1Z P;  3NKP A;  2IUC A;  3M8W A;  5K4P A;  1URA A;  2D1G A;  2QZU A;  3IGZ B;  3TG0 A;  4KM4 A;  1ANJ A;  3MK1 A;  3ED4 A;  4KJD A;  5C66 A;  2GSN A;  5LRN A;  1ELZ A;  3NKM A;  4UOR A;  2IUC B;  3M8Z A;  1KHJ A;  3WAX A;  4LRC A;  1Y6V A;  3T00 A;  5LQQ A;  1KH5 A;  3DPC A;  4FDI A;  4NWJ A;  3NKO A;  5GOV A;  3WAY A;  3BDG B;  4KAY A;  1Y7A A;  3UN3 A;  1EW8 A;  4LR2 A;  3UN2 A;  4N7T A;  4ZG6 A;  5DLT A;  1O98 A;  1SHN A;  3NKQ A;  1ANI A;  1E2S P;  4CXK A;  1KHK A;  4FDJ A;  4NWX A;  4MHX A;  5TJ3 A;  4GTY A;  3TWZ A;  4LRA A;  2ZKT A;  1KH7 A;  4GTW A;  4LQY A;  3IDD A;  1EW2 A;  1FSU A;  3KD8 A;  1ALK A;  3BDG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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