1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
4FDIA 2W5XA 1ED8A 5TJ3A 3DYCA 3CMRA 2G9YA 1EW9A 1AJDA 1ELXA 3BDGB 1ALJA 3IDDA 1Y6VA 4LRFA 3UNYA 1EW2A 2D1GA 1ELZA 3MK1A 5EGHA 3NKRA 4QAXA 2IUCA 1N2LA 5GOVA 5K4PA 4ZG7A 3SZYA 4UPLA 3B5QA 5IJSA 2XRGA 3DPCA 3LXQA 4KJDA 4UOOA 2W5RA 3M8WA 4ZG6A 4FDJA 2GLQA 3M8YA 2XR9A 1KH7A 1ANIA 5LIAA 1KHNA 1URAA 1AJAA 3SZZA 4LRDA 3MK0A 5L0BA 1HJKA 1HQAA 1EI6A 1Y7AA 4GTXA 2IUCB 3UN3A 5HRTA 1ZEBA 1EJJA 1ZEDA 2RH6A 2W5TA 4UOPA 1KHLA 1HDHA 1KHKA 3WAXA 1ALHA 3T02A 3WBHA 1E2SP 4CYSA 3OT9A 4YR1A 4UPKA 4CXKA 3IGZB 3UN5A 5DLVA 2ZKTA 3UN2A 3M8ZA 2GSOA 2GSNA 4KAYA 1FSUA 2W5WA 4UORA 1EQJA 2W8SA 4LR8A 4LR9A 3BDHA 4TN0A 3NKMA 1AUKA 2W5VA 2W5SA 4ZGAA 1ANJA 4MIVA 1EW8A 5KXAA 1ZEFA 3KD8A 4GTYA 4CYRA 1KH5A 3E2DA 3ED4A 1URBA 5LQQA 4CXSA 3NKPA 5GRRA 1SHQA 1B8JA 5IJQA 1O98A 4LRCA 1K7HA 4N7TA 3WAWA 1ALKA 4LQYA 1E1ZP 3M7VA 5DLWA 4ZG9A 1O99A 4KAVA 5INHA 2GA3A 3TWZA 4LR7A 5EGEA 1KH4A 3NKNA 3NKQA 2W8DA 5LRMA 1E3CP 1AJBA 4KM4A 5LRNA 4UPHA 4B56A 3BDFA 1ALIA 5DLTA 4MY4A 1E33P 3NVLA 1KHJA 5L0EA 4KJGA 3MK2A 5L0KA 2W5QA 3TX0A 2X98A 3UO0A 4LRBA 4NWJA 2GSUA 3T00A 1ELYA 3A52A 4LREA 3TG0A 3BDGA 1N2KA 4GTWA 4MHXA 1SHNA 4CXUA 3Q3QA 5AJ9A 1ED9A 4NWXA 1P49A 4LR2A 4GTZA 4LRAA 2QZUA 2IFYA 1AJCA 5C66A 2ANHA 3NKOA 4UPIA 3WAVA 3WAYA 3IGYB 3T01A 1KH9A 2VQRA
chains in the Genus database with same CATH superfamily
4FDIA 2W5XA 1ED8A 5TJ3A 3DYCA 3CMRA 2G9YA 1EW9A 1AJDA 1ELXA 3BDGB 1ALJA 3IDDA 1Y6VA 4LRFA 3UNYA 1EW2A 2D1GA 1ELZA 3MK1A 5EGHA 3NKRA 4QAXA 2IUCA 1N2LA 5GOVA 5K4PA 4ZG7A 3SZYA 4UPLA 3B5QA 5IJSA 2XRGA 3DPCA 3LXQA 4KJDA 4UOOA 2W5RA 3M8WA 4ZG6A 4FDJA 2GLQA 3M8YA 2XR9A 1KH7A 1ANIA 5LIAA 1KHNA 1URAA 1AJAA 3SZZA 4LRDA 3MK0A 5L0BA 1HJKA 1HQAA 1EI6A 1Y7AA 4GTXA 2IUCB 3UN3A 5HRTA 1ZEBA 1EJJA 1ZEDA 2RH6A 2W5TA 4UOPA 1KHLA 1HDHA 1KHKA 3WAXA 1ALHA 3T02A 3WBHA 1E2SP 4CYSA 3OT9A 4YR1A 4UPKA 4CXKA 3IGZB 3UN5A 5DLVA 2ZKTA 3UN2A 3M8ZA 2GSOA 2GSNA 4KAYA 1FSUA 2W5WA 4UORA 1EQJA 2W8SA 4LR8A 4LR9A 3BDHA 4TN0A 3NKMA 1AUKA 2W5VA 2W5SA 4ZGAA 1ANJA 4MIVA 1EW8A 5KXAA 1ZEFA 3KD8A 4GTYA 4CYRA 1KH5A 3E2DA 3ED4A 1URBA 5LQQA 4CXSA 3NKPA 5GRRA 1SHQA 1B8JA 5IJQA 1O98A 4LRCA 1K7HA 4N7TA 3WAWA 1ALKA 4LQYA 1E1ZP 3M7VA 5DLWA 4ZG9A 1O99A 4KAVA 5INHA 2GA3A 3TWZA 4LR7A 5EGEA 1KH4A 3NKNA 3NKQA 2W8DA 5LRMA 1E3CP 1AJBA 4KM4A 5LRNA 4UPHA 4B56A 3BDFA 1ALIA 5DLTA 4MY4A 1E33P 3NVLA 1KHJA 5L0EA 4KJGA 3MK2A 5L0KA 2W5QA 3TX0A 2X98A 3UO0A 4LRBA 4NWJA 2GSUA 3T00A 1ELYA 3A52A 4LREA 3TG0A 3BDGA 1N2KA 4GTWA 4MHXA 1SHNA 4CXUA 3Q3QA 5AJ9A 1ED9A 4NWXA 1P49A 4LR2A 4GTZA 4LRAA 2QZUA 2IFYA 1AJCA 5C66A 2ANHA 3NKOA 4UPIA 3WAVA 3WAYA 3IGYB 3T01A 1KH9A 2VQRA
chains in the Genus database with same CATH topology
4FDIA 2W5XA 1ED8A 5TJ3A 3DYCA 3CMRA 2G9YA 1EW9A 1AJDA 1ELXA 3BDGB 1ALJA 3IDDA 1Y6VA 4LRFA 3UNYA 1EW2A 2D1GA 1ELZA 3MK1A 5EGHA 3NKRA 4QAXA 2IUCA 1N2LA 5GOVA 5K4PA 4ZG7A 3SZYA 4UPLA 3B5QA 5IJSA 2XRGA 3DPCA 3LXQA 4KJDA 4UOOA 2W5RA 3M8WA 4ZG6A 4FDJA 2GLQA 3M8YA 2XR9A 1KH7A 1ANIA 5LIAA 1KHNA 1URAA 1AJAA 3SZZA 4LRDA 3MK0A 5L0BA 1HJKA 1HQAA 1EI6A 1Y7AA 4GTXA 2IUCB 3UN3A 5HRTA 1ZEBA 1EJJA 1ZEDA 2RH6A 2W5TA 4UOPA 1KHLA 1HDHA 1KHKA 3WAXA 1ALHA 3T02A 3WBHA 1E2SP 4CYSA 3OT9A 4YR1A 4UPKA 4CXKA 3IGZB 3UN5A 5DLVA 2ZKTA 3UN2A 3M8ZA 2GSOA 2GSNA 4KAYA 1FSUA 2W5WA 4UORA 1EQJA 2W8SA 4LR8A 4LR9A 3BDHA 4TN0A 3NKMA 1AUKA 2W5VA 2W5SA 4ZGAA 1ANJA 4MIVA 1EW8A 5KXAA 1ZEFA 3KD8A 4GTYA 4CYRA 1KH5A 3E2DA 3ED4A 1URBA 5LQQA 4CXSA 3NKPA 5GRRA 1SHQA 1B8JA 5IJQA 1O98A 4LRCA 1K7HA 4N7TA 3WAWA 1ALKA 4LQYA 1E1ZP 3M7VA 5DLWA 4ZG9A 1O99A 4KAVA 5INHA 2GA3A 3TWZA 4LR7A 5EGEA 1KH4A 3NKNA 3NKQA 2W8DA 5LRMA 1E3CP 1AJBA 4KM4A 5LRNA 4UPHA 4B56A 3BDFA 1ALIA 5DLTA 4MY4A 1E33P 3NVLA 1KHJA 5L0EA 4KJGA 3MK2A 5L0KA 2W5QA 3TX0A 2X98A 3UO0A 4LRBA 4NWJA 2GSUA 3T00A 1ELYA 3A52A 4LREA 3TG0A 3BDGA 1N2KA 4GTWA 4MHXA 1SHNA 4CXUA 3Q3QA 5AJ9A 1ED9A 4NWXA 1P49A 4LR2A 4GTZA 4LRAA 2QZUA 2IFYA 1AJCA 5C66A 2ANHA 3NKOA 4UPIA 3WAVA 3WAYA 3IGYB 3T01A 1KH9A 2VQRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FDI A;  2W5X A;  1ED8 A;  5TJ3 A;  3DYC A;  3CMR A;  2G9Y A;  1EW9 A;  1AJD A;  1ELX A;  3BDG B;  1ALJ A;  3IDD A;  1Y6V A;  4LRF A;  3UNY A;  1EW2 A;  2D1G A;  1ELZ A;  3MK1 A;  5EGH A;  3NKR A;  4QAX A;  2IUC A;  1N2L A;  5GOV A;  5K4P A;  4ZG7 A;  3SZY A;  4UPL A;  3B5Q A;  5IJS A;  2XRG A;  3DPC A;  3LXQ A;  4KJD A;  4UOO A;  2W5R A;  3M8W A;  4ZG6 A;  4FDJ A;  2GLQ A;  3M8Y A;  2XR9 A;  1KH7 A;  1ANI A;  5LIA A;  1KHN A;  1URA A;  1AJA A;  3SZZ A;  4LRD A;  3MK0 A;  5L0B A;  1HJK A;  1HQA A;  1EI6 A;  1Y7A A;  4GTX A;  2IUC B;  3UN3 A;  5HRT A;  1ZEB A;  1EJJ A;  1ZED A;  2RH6 A;  2W5T A;  4UOP A;  1KHL A;  1HDH A;  1KHK A;  3WAX A;  1ALH A;  3T02 A;  3WBH A;  1E2S P;  4CYS A;  3OT9 A;  4YR1 A;  4UPK A;  4CXK A;  3IGZ B;  3UN5 A;  5DLV A;  2ZKT A;  3UN2 A;  3M8Z A;  2GSO A;  2GSN A;  4KAY A;  1FSU A;  2W5W A;  4UOR A;  1EQJ A;  2W8S A;  4LR8 A;  4LR9 A;  3BDH A;  4TN0 A;  3NKM A;  1AUK A;  2W5V A;  2W5S A;  4ZGA A;  1ANJ A;  4MIV A;  1EW8 A;  5KXA A;  1ZEF A;  3KD8 A;  4GTY A;  4CYR A;  1KH5 A;  3E2D A;  3ED4 A;  1URB A;  5LQQ A;  4CXS A;  3NKP A;  5GRR A;  1SHQ A;  1B8J A;  5IJQ A;  1O98 A;  4LRC A;  1K7H A;  4N7T A;  3WAW A;  1ALK A;  4LQY A;  1E1Z P;  3M7V A;  5DLW A;  4ZG9 A;  1O99 A;  4KAV A;  5INH A;  2GA3 A;  3TWZ A;  4LR7 A;  5EGE A;  1KH4 A;  3NKN A;  3NKQ A;  2W8D A;  5LRM A;  1E3C P;  1AJB A;  4KM4 A;  5LRN A;  4UPH A;  4B56 A;  3BDF A;  1ALI A;  5DLT A;  4MY4 A;  1E33 P;  3NVL A;  1KHJ A;  5L0E A;  4KJG A;  3MK2 A;  5L0K A;  2W5Q A;  3TX0 A;  2X98 A;  3UO0 A;  4LRB A;  4NWJ A;  2GSU A;  3T00 A;  1ELY A;  3A52 A;  4LRE A;  3TG0 A;  3BDG A;  1N2K A;  4GTW A;  4MHX A;  1SHN A;  4CXU A;  3Q3Q A;  5AJ9 A;  1ED9 A;  4NWX A;  1P49 A;  4LR2 A;  4GTZ A;  4LRA A;  2QZU A;  2IFY A;  1AJC A;  5C66 A;  2ANH A;  3NKO A;  4UPI A;  3WAV A;  3WAY A;  3IGY B;  3T01 A;  1KH9 A;  2VQR A; 
#chains in the Genus database with same CATH topology
 4FDI A;  2W5X A;  1ED8 A;  5TJ3 A;  3DYC A;  3CMR A;  2G9Y A;  1EW9 A;  1AJD A;  1ELX A;  3BDG B;  1ALJ A;  3IDD A;  1Y6V A;  4LRF A;  3UNY A;  1EW2 A;  2D1G A;  1ELZ A;  3MK1 A;  5EGH A;  3NKR A;  4QAX A;  2IUC A;  1N2L A;  5GOV A;  5K4P A;  4ZG7 A;  3SZY A;  4UPL A;  3B5Q A;  5IJS A;  2XRG A;  3DPC A;  3LXQ A;  4KJD A;  4UOO A;  2W5R A;  3M8W A;  4ZG6 A;  4FDJ A;  2GLQ A;  3M8Y A;  2XR9 A;  1KH7 A;  1ANI A;  5LIA A;  1KHN A;  1URA A;  1AJA A;  3SZZ A;  4LRD A;  3MK0 A;  5L0B A;  1HJK A;  1HQA A;  1EI6 A;  1Y7A A;  4GTX A;  2IUC B;  3UN3 A;  5HRT A;  1ZEB A;  1EJJ A;  1ZED A;  2RH6 A;  2W5T A;  4UOP A;  1KHL A;  1HDH A;  1KHK A;  3WAX A;  1ALH A;  3T02 A;  3WBH A;  1E2S P;  4CYS A;  3OT9 A;  4YR1 A;  4UPK A;  4CXK A;  3IGZ B;  3UN5 A;  5DLV A;  2ZKT A;  3UN2 A;  3M8Z A;  2GSO A;  2GSN A;  4KAY A;  1FSU A;  2W5W A;  4UOR A;  1EQJ A;  2W8S A;  4LR8 A;  4LR9 A;  3BDH A;  4TN0 A;  3NKM A;  1AUK A;  2W5V A;  2W5S A;  4ZGA A;  1ANJ A;  4MIV A;  1EW8 A;  5KXA A;  1ZEF A;  3KD8 A;  4GTY A;  4CYR A;  1KH5 A;  3E2D A;  3ED4 A;  1URB A;  5LQQ A;  4CXS A;  3NKP A;  5GRR A;  1SHQ A;  1B8J A;  5IJQ A;  1O98 A;  4LRC A;  1K7H A;  4N7T A;  3WAW A;  1ALK A;  4LQY A;  1E1Z P;  3M7V A;  5DLW A;  4ZG9 A;  1O99 A;  4KAV A;  5INH A;  2GA3 A;  3TWZ A;  4LR7 A;  5EGE A;  1KH4 A;  3NKN A;  3NKQ A;  2W8D A;  5LRM A;  1E3C P;  1AJB A;  4KM4 A;  5LRN A;  4UPH A;  4B56 A;  3BDF A;  1ALI A;  5DLT A;  4MY4 A;  1E33 P;  3NVL A;  1KHJ A;  5L0E A;  4KJG A;  3MK2 A;  5L0K A;  2W5Q A;  3TX0 A;  2X98 A;  3UO0 A;  4LRB A;  4NWJ A;  2GSU A;  3T00 A;  1ELY A;  3A52 A;  4LRE A;  3TG0 A;  3BDG A;  1N2K A;  4GTW A;  4MHX A;  1SHN A;  4CXU A;  3Q3Q A;  5AJ9 A;  1ED9 A;  4NWX A;  1P49 A;  4LR2 A;  4GTZ A;  4LRA A;  2QZU A;  2IFY A;  1AJC A;  5C66 A;  2ANH A;  3NKO A;  4UPI A;  3WAV A;  3WAY A;  3IGY B;  3T01 A;  1KH9 A;  2VQR A; 
#chains in the Genus database with same CATH homology
 4FDI A;  2W5X A;  1ED8 A;  5TJ3 A;  3DYC A;  3CMR A;  2G9Y A;  1EW9 A;  1AJD A;  1ELX A;  3BDG B;  1ALJ A;  3IDD A;  1Y6V A;  4LRF A;  3UNY A;  1EW2 A;  2D1G A;  1ELZ A;  3MK1 A;  5EGH A;  3NKR A;  4QAX A;  2IUC A;  1N2L A;  5GOV A;  5K4P A;  4ZG7 A;  3SZY A;  4UPL A;  3B5Q A;  5IJS A;  2XRG A;  3DPC A;  3LXQ A;  4KJD A;  4UOO A;  2W5R A;  3M8W A;  4ZG6 A;  4FDJ A;  2GLQ A;  3M8Y A;  2XR9 A;  1KH7 A;  1ANI A;  5LIA A;  1KHN A;  1URA A;  1AJA A;  3SZZ A;  4LRD A;  3MK0 A;  5L0B A;  1HJK A;  1HQA A;  1EI6 A;  1Y7A A;  4GTX A;  2IUC B;  3UN3 A;  5HRT A;  1ZEB A;  1EJJ A;  1ZED A;  2RH6 A;  2W5T A;  4UOP A;  1KHL A;  1HDH A;  1KHK A;  3WAX A;  1ALH A;  3T02 A;  3WBH A;  1E2S P;  4CYS A;  3OT9 A;  4YR1 A;  4UPK A;  4CXK A;  3IGZ B;  3UN5 A;  5DLV A;  2ZKT A;  3UN2 A;  3M8Z A;  2GSO A;  2GSN A;  4KAY A;  1FSU A;  2W5W A;  4UOR A;  1EQJ A;  2W8S A;  4LR8 A;  4LR9 A;  3BDH A;  4TN0 A;  3NKM A;  1AUK A;  2W5V A;  2W5S A;  4ZGA A;  1ANJ A;  4MIV A;  1EW8 A;  5KXA A;  1ZEF A;  3KD8 A;  4GTY A;  4CYR A;  1KH5 A;  3E2D A;  3ED4 A;  1URB A;  5LQQ A;  4CXS A;  3NKP A;  5GRR A;  1SHQ A;  1B8J A;  5IJQ A;  1O98 A;  4LRC A;  1K7H A;  4N7T A;  3WAW A;  1ALK A;  4LQY A;  1E1Z P;  3M7V A;  5DLW A;  4ZG9 A;  1O99 A;  4KAV A;  5INH A;  2GA3 A;  3TWZ A;  4LR7 A;  5EGE A;  1KH4 A;  3NKN A;  3NKQ A;  2W8D A;  5LRM A;  1E3C P;  1AJB A;  4KM4 A;  5LRN A;  4UPH A;  4B56 A;  3BDF A;  1ALI A;  5DLT A;  4MY4 A;  1E33 P;  3NVL A;  1KHJ A;  5L0E A;  4KJG A;  3MK2 A;  5L0K A;  2W5Q A;  3TX0 A;  2X98 A;  3UO0 A;  4LRB A;  4NWJ A;  2GSU A;  3T00 A;  1ELY A;  3A52 A;  4LRE A;  3TG0 A;  3BDG A;  1N2K A;  4GTW A;  4MHX A;  1SHN A;  4CXU A;  3Q3Q A;  5AJ9 A;  1ED9 A;  4NWX A;  1P49 A;  4LR2 A;  4GTZ A;  4LRA A;  2QZU A;  2IFY A;  1AJC A;  5C66 A;  2ANH A;  3NKO A;  4UPI A;  3WAV A;  3WAY A;  3IGY B;  3T01 A;  1KH9 A;  2VQR A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...