1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
3BDGA 3UN5A 4LREA 4UOPA 1K7HA 2VQRA 1Y6VA 1AJAA 1ED9A 1EI6A 3NVLA 1EW2A 1AJBA 2GA3A 4UOOA 1ANJA 1ZEDA 4MY4A 1HDHA 3B5QA 3IGYB 2IUCA 5DLVA 4KJGA 4GTWA 4UPLA 2IFYA 3Q3QA 2GSOA 5L0EA 2GSUA 4LQYA 5LQQA 5KXAA 1KH7A 1ALIA 1KH5A 3BDFA 5GOVA 4ZG7A 1HQAA 2GLQA 5DLTA 1AUKA 3T01A 3M8ZA 1KH9A 4ZG6A 4LR7A 5EGEA 3T02A 4N7TA 1N2KA 1KHNA 4MIVA 2D1GA 5HRTA 5LRNA 4FDJA 4LR2A 1ANIA 1FSUA 1ZEFA 3UO0A 1P49A 3TX0A 1SHQA 2W8SA 4LR8A 5L0KA 1HJKA 2XRGA 4MHXA 3WAXA 3T00A 3M8WA 1ELXA 3NKPA 4GTZA 4UORA 1KH4A 3E2DA 1O98A 2G9YA 3NKNA 3UNYA 5GRRA 3KD8A 4KJDA 3ED4A 1ALHA 4CYSA 1ELYA 3SZYA 5K4PA 4CYRA 3NKOA 3TWZA 2X98A 3MK2A 3UN2A 1KHLA 4ZGAA 4NWXA 2W5TA 1EQJA 3WBHA 1AJDA 3M7VA 5IJSA 4LRFA 3NKMA 2XR9A 4LRDA 1ALKA 1EW9A 3OT9A 1EW8A 4LRAA 3MK1A 4CXSA 5IJQA 4LRBA 3NKQA 5C66A 2QZUA 1E1ZP 2W5QA 5AJ9A 3IDDA 4UPKA 3DPCA 4CXUA 3DYCA 3SZZA 3WAVA 3BDHA 2ZKTA 4YR1A 3MK0A 4KAYA 5TJ3A 3M8YA 5INHA 3TG0A 1E2SP 2RH6A 3LXQA 4LRCA 1B8JA 1ED8A 4UPIA 1URAA 4FDIA 4NWJA 2W5SA 1KHKA 4TN0A 2W5XA 4CXKA 2W5RA 5DLWA 3CMRA 4B56A 5LRMA 1KHJA 4GTXA 4LR9A 3UN3A 5EGHA 4UPHA 3BDGB 5L0BA 5LIAA 1E3CP 3NKRA 2ANHA 2W5WA 2W8DA 1URBA 1ALJA 2W5VA 4ZG9A 4KAVA 1E33P 2GSNA 1EJJA 1ZEBA 1SHNA 2IUCB 3WAYA 1ELZA 1Y7AA 1N2LA 3A52A 1O99A 3IGZB 4GTYA 4QAXA 3WAWA 4KM4A 1AJCA
chains in the Genus database with same CATH superfamily
3BDGA 3UN5A 4LREA 4UOPA 1K7HA 2VQRA 1Y6VA 1AJAA 1ED9A 1EI6A 3NVLA 1EW2A 1AJBA 2GA3A 4UOOA 1ANJA 1ZEDA 4MY4A 1HDHA 3B5QA 3IGYB 2IUCA 5DLVA 4KJGA 4GTWA 4UPLA 2IFYA 3Q3QA 2GSOA 5L0EA 2GSUA 4LQYA 5LQQA 5KXAA 1KH7A 1ALIA 1KH5A 3BDFA 5GOVA 4ZG7A 1HQAA 2GLQA 5DLTA 1AUKA 3T01A 3M8ZA 1KH9A 4ZG6A 4LR7A 5EGEA 3T02A 4N7TA 1N2KA 1KHNA 4MIVA 2D1GA 5HRTA 5LRNA 4FDJA 4LR2A 1ANIA 1FSUA 1ZEFA 3UO0A 1P49A 3TX0A 1SHQA 2W8SA 4LR8A 5L0KA 1HJKA 2XRGA 4MHXA 3WAXA 3T00A 3M8WA 1ELXA 3NKPA 4GTZA 4UORA 1KH4A 3E2DA 1O98A 2G9YA 3NKNA 3UNYA 5GRRA 3KD8A 4KJDA 3ED4A 1ALHA 4CYSA 1ELYA 3SZYA 5K4PA 4CYRA 3NKOA 3TWZA 2X98A 3MK2A 3UN2A 1KHLA 4ZGAA 4NWXA 2W5TA 1EQJA 3WBHA 1AJDA 3M7VA 5IJSA 4LRFA 3NKMA 2XR9A 4LRDA 1ALKA 1EW9A 3OT9A 1EW8A 4LRAA 3MK1A 4CXSA 5IJQA 4LRBA 3NKQA 5C66A 2QZUA 1E1ZP 2W5QA 5AJ9A 3IDDA 4UPKA 3DPCA 4CXUA 3DYCA 3SZZA 3WAVA 3BDHA 2ZKTA 4YR1A 3MK0A 4KAYA 5TJ3A 3M8YA 5INHA 3TG0A 1E2SP 2RH6A 3LXQA 4LRCA 1B8JA 1ED8A 4UPIA 1URAA 4FDIA 4NWJA 2W5SA 1KHKA 4TN0A 2W5XA 4CXKA 2W5RA 5DLWA 3CMRA 4B56A 5LRMA 1KHJA 4GTXA 4LR9A 3UN3A 5EGHA 4UPHA 3BDGB 5L0BA 5LIAA 1E3CP 3NKRA 2ANHA 2W5WA 2W8DA 1URBA 1ALJA 2W5VA 4ZG9A 4KAVA 1E33P 2GSNA 1EJJA 1ZEBA 1SHNA 2IUCB 3WAYA 1ELZA 1Y7AA 1N2LA 3A52A 1O99A 3IGZB 4GTYA 4QAXA 3WAWA 4KM4A 1AJCA
chains in the Genus database with same CATH topology
3BDGA 3UN5A 4LREA 4UOPA 1K7HA 2VQRA 1Y6VA 1AJAA 1ED9A 1EI6A 3NVLA 1EW2A 1AJBA 2GA3A 4UOOA 1ANJA 1ZEDA 4MY4A 1HDHA 3B5QA 3IGYB 2IUCA 5DLVA 4KJGA 4GTWA 4UPLA 2IFYA 3Q3QA 2GSOA 5L0EA 2GSUA 4LQYA 5LQQA 5KXAA 1KH7A 1ALIA 1KH5A 3BDFA 5GOVA 4ZG7A 1HQAA 2GLQA 5DLTA 1AUKA 3T01A 3M8ZA 1KH9A 4ZG6A 4LR7A 5EGEA 3T02A 4N7TA 1N2KA 1KHNA 4MIVA 2D1GA 5HRTA 5LRNA 4FDJA 4LR2A 1ANIA 1FSUA 1ZEFA 3UO0A 1P49A 3TX0A 1SHQA 2W8SA 4LR8A 5L0KA 1HJKA 2XRGA 4MHXA 3WAXA 3T00A 3M8WA 1ELXA 3NKPA 4GTZA 4UORA 1KH4A 3E2DA 1O98A 2G9YA 3NKNA 3UNYA 5GRRA 3KD8A 4KJDA 3ED4A 1ALHA 4CYSA 1ELYA 3SZYA 5K4PA 4CYRA 3NKOA 3TWZA 2X98A 3MK2A 3UN2A 1KHLA 4ZGAA 4NWXA 2W5TA 1EQJA 3WBHA 1AJDA 3M7VA 5IJSA 4LRFA 3NKMA 2XR9A 4LRDA 1ALKA 1EW9A 3OT9A 1EW8A 4LRAA 3MK1A 4CXSA 5IJQA 4LRBA 3NKQA 5C66A 2QZUA 1E1ZP 2W5QA 5AJ9A 3IDDA 4UPKA 3DPCA 4CXUA 3DYCA 3SZZA 3WAVA 3BDHA 2ZKTA 4YR1A 3MK0A 4KAYA 5TJ3A 3M8YA 5INHA 3TG0A 1E2SP 2RH6A 3LXQA 4LRCA 1B8JA 1ED8A 4UPIA 1URAA 4FDIA 4NWJA 2W5SA 1KHKA 4TN0A 2W5XA 4CXKA 2W5RA 5DLWA 3CMRA 4B56A 5LRMA 1KHJA 4GTXA 4LR9A 3UN3A 5EGHA 4UPHA 3BDGB 5L0BA 5LIAA 1E3CP 3NKRA 2ANHA 2W5WA 2W8DA 1URBA 1ALJA 2W5VA 4ZG9A 4KAVA 1E33P 2GSNA 1EJJA 1ZEBA 1SHNA 2IUCB 3WAYA 1ELZA 1Y7AA 1N2LA 3A52A 1O99A 3IGZB 4GTYA 4QAXA 3WAWA 4KM4A 1AJCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDG A;  3UN5 A;  4LRE A;  4UOP A;  1K7H A;  2VQR A;  1Y6V A;  1AJA A;  1ED9 A;  1EI6 A;  3NVL A;  1EW2 A;  1AJB A;  2GA3 A;  4UOO A;  1ANJ A;  1ZED A;  4MY4 A;  1HDH A;  3B5Q A;  3IGY B;  2IUC A;  5DLV A;  4KJG A;  4GTW A;  4UPL A;  2IFY A;  3Q3Q A;  2GSO A;  5L0E A;  2GSU A;  4LQY A;  5LQQ A;  5KXA A;  1KH7 A;  1ALI A;  1KH5 A;  3BDF A;  5GOV A;  4ZG7 A;  1HQA A;  2GLQ A;  5DLT A;  1AUK A;  3T01 A;  3M8Z A;  1KH9 A;  4ZG6 A;  4LR7 A;  5EGE A;  3T02 A;  4N7T A;  1N2K A;  1KHN A;  4MIV A;  2D1G A;  5HRT A;  5LRN A;  4FDJ A;  4LR2 A;  1ANI A;  1FSU A;  1ZEF A;  3UO0 A;  1P49 A;  3TX0 A;  1SHQ A;  2W8S A;  4LR8 A;  5L0K A;  1HJK A;  2XRG A;  4MHX A;  3WAX A;  3T00 A;  3M8W A;  1ELX A;  3NKP A;  4GTZ A;  4UOR A;  1KH4 A;  3E2D A;  1O98 A;  2G9Y A;  3NKN A;  3UNY A;  5GRR A;  3KD8 A;  4KJD A;  3ED4 A;  1ALH A;  4CYS A;  1ELY A;  3SZY A;  5K4P A;  4CYR A;  3NKO A;  3TWZ A;  2X98 A;  3MK2 A;  3UN2 A;  1KHL A;  4ZGA A;  4NWX A;  2W5T A;  1EQJ A;  3WBH A;  1AJD A;  3M7V A;  5IJS A;  4LRF A;  3NKM A;  2XR9 A;  4LRD A;  1ALK A;  1EW9 A;  3OT9 A;  1EW8 A;  4LRA A;  3MK1 A;  4CXS A;  5IJQ A;  4LRB A;  3NKQ A;  5C66 A;  2QZU A;  1E1Z P;  2W5Q A;  5AJ9 A;  3IDD A;  4UPK A;  3DPC A;  4CXU A;  3DYC A;  3SZZ A;  3WAV A;  3BDH A;  2ZKT A;  4YR1 A;  3MK0 A;  4KAY A;  5TJ3 A;  3M8Y A;  5INH A;  3TG0 A;  1E2S P;  2RH6 A;  3LXQ A;  4LRC A;  1B8J A;  1ED8 A;  4UPI A;  1URA A;  4FDI A;  4NWJ A;  2W5S A;  1KHK A;  4TN0 A;  2W5X A;  4CXK A;  2W5R A;  5DLW A;  3CMR A;  4B56 A;  5LRM A;  1KHJ A;  4GTX A;  4LR9 A;  3UN3 A;  5EGH A;  4UPH A;  3BDG B;  5L0B A;  5LIA A;  1E3C P;  3NKR A;  2ANH A;  2W5W A;  2W8D A;  1URB A;  1ALJ A;  2W5V A;  4ZG9 A;  4KAV A;  1E33 P;  2GSN A;  1EJJ A;  1ZEB A;  1SHN A;  2IUC B;  3WAY A;  1ELZ A;  1Y7A A;  1N2L A;  3A52 A;  1O99 A;  3IGZ B;  4GTY A;  4QAX A;  3WAW A;  4KM4 A;  1AJC A; 
#chains in the Genus database with same CATH topology
 3BDG A;  3UN5 A;  4LRE A;  4UOP A;  1K7H A;  2VQR A;  1Y6V A;  1AJA A;  1ED9 A;  1EI6 A;  3NVL A;  1EW2 A;  1AJB A;  2GA3 A;  4UOO A;  1ANJ A;  1ZED A;  4MY4 A;  1HDH A;  3B5Q A;  3IGY B;  2IUC A;  5DLV A;  4KJG A;  4GTW A;  4UPL A;  2IFY A;  3Q3Q A;  2GSO A;  5L0E A;  2GSU A;  4LQY A;  5LQQ A;  5KXA A;  1KH7 A;  1ALI A;  1KH5 A;  3BDF A;  5GOV A;  4ZG7 A;  1HQA A;  2GLQ A;  5DLT A;  1AUK A;  3T01 A;  3M8Z A;  1KH9 A;  4ZG6 A;  4LR7 A;  5EGE A;  3T02 A;  4N7T A;  1N2K A;  1KHN A;  4MIV A;  2D1G A;  5HRT A;  5LRN A;  4FDJ A;  4LR2 A;  1ANI A;  1FSU A;  1ZEF A;  3UO0 A;  1P49 A;  3TX0 A;  1SHQ A;  2W8S A;  4LR8 A;  5L0K A;  1HJK A;  2XRG A;  4MHX A;  3WAX A;  3T00 A;  3M8W A;  1ELX A;  3NKP A;  4GTZ A;  4UOR A;  1KH4 A;  3E2D A;  1O98 A;  2G9Y A;  3NKN A;  3UNY A;  5GRR A;  3KD8 A;  4KJD A;  3ED4 A;  1ALH A;  4CYS A;  1ELY A;  3SZY A;  5K4P A;  4CYR A;  3NKO A;  3TWZ A;  2X98 A;  3MK2 A;  3UN2 A;  1KHL A;  4ZGA A;  4NWX A;  2W5T A;  1EQJ A;  3WBH A;  1AJD A;  3M7V A;  5IJS A;  4LRF A;  3NKM A;  2XR9 A;  4LRD A;  1ALK A;  1EW9 A;  3OT9 A;  1EW8 A;  4LRA A;  3MK1 A;  4CXS A;  5IJQ A;  4LRB A;  3NKQ A;  5C66 A;  2QZU A;  1E1Z P;  2W5Q A;  5AJ9 A;  3IDD A;  4UPK A;  3DPC A;  4CXU A;  3DYC A;  3SZZ A;  3WAV A;  3BDH A;  2ZKT A;  4YR1 A;  3MK0 A;  4KAY A;  5TJ3 A;  3M8Y A;  5INH A;  3TG0 A;  1E2S P;  2RH6 A;  3LXQ A;  4LRC A;  1B8J A;  1ED8 A;  4UPI A;  1URA A;  4FDI A;  4NWJ A;  2W5S A;  1KHK A;  4TN0 A;  2W5X A;  4CXK A;  2W5R A;  5DLW A;  3CMR A;  4B56 A;  5LRM A;  1KHJ A;  4GTX A;  4LR9 A;  3UN3 A;  5EGH A;  4UPH A;  3BDG B;  5L0B A;  5LIA A;  1E3C P;  3NKR A;  2ANH A;  2W5W A;  2W8D A;  1URB A;  1ALJ A;  2W5V A;  4ZG9 A;  4KAV A;  1E33 P;  2GSN A;  1EJJ A;  1ZEB A;  1SHN A;  2IUC B;  3WAY A;  1ELZ A;  1Y7A A;  1N2L A;  3A52 A;  1O99 A;  3IGZ B;  4GTY A;  4QAX A;  3WAW A;  4KM4 A;  1AJC A; 
#chains in the Genus database with same CATH homology
 3BDG A;  3UN5 A;  4LRE A;  4UOP A;  1K7H A;  2VQR A;  1Y6V A;  1AJA A;  1ED9 A;  1EI6 A;  3NVL A;  1EW2 A;  1AJB A;  2GA3 A;  4UOO A;  1ANJ A;  1ZED A;  4MY4 A;  1HDH A;  3B5Q A;  3IGY B;  2IUC A;  5DLV A;  4KJG A;  4GTW A;  4UPL A;  2IFY A;  3Q3Q A;  2GSO A;  5L0E A;  2GSU A;  4LQY A;  5LQQ A;  5KXA A;  1KH7 A;  1ALI A;  1KH5 A;  3BDF A;  5GOV A;  4ZG7 A;  1HQA A;  2GLQ A;  5DLT A;  1AUK A;  3T01 A;  3M8Z A;  1KH9 A;  4ZG6 A;  4LR7 A;  5EGE A;  3T02 A;  4N7T A;  1N2K A;  1KHN A;  4MIV A;  2D1G A;  5HRT A;  5LRN A;  4FDJ A;  4LR2 A;  1ANI A;  1FSU A;  1ZEF A;  3UO0 A;  1P49 A;  3TX0 A;  1SHQ A;  2W8S A;  4LR8 A;  5L0K A;  1HJK A;  2XRG A;  4MHX A;  3WAX A;  3T00 A;  3M8W A;  1ELX A;  3NKP A;  4GTZ A;  4UOR A;  1KH4 A;  3E2D A;  1O98 A;  2G9Y A;  3NKN A;  3UNY A;  5GRR A;  3KD8 A;  4KJD A;  3ED4 A;  1ALH A;  4CYS A;  1ELY A;  3SZY A;  5K4P A;  4CYR A;  3NKO A;  3TWZ A;  2X98 A;  3MK2 A;  3UN2 A;  1KHL A;  4ZGA A;  4NWX A;  2W5T A;  1EQJ A;  3WBH A;  1AJD A;  3M7V A;  5IJS A;  4LRF A;  3NKM A;  2XR9 A;  4LRD A;  1ALK A;  1EW9 A;  3OT9 A;  1EW8 A;  4LRA A;  3MK1 A;  4CXS A;  5IJQ A;  4LRB A;  3NKQ A;  5C66 A;  2QZU A;  1E1Z P;  2W5Q A;  5AJ9 A;  3IDD A;  4UPK A;  3DPC A;  4CXU A;  3DYC A;  3SZZ A;  3WAV A;  3BDH A;  2ZKT A;  4YR1 A;  3MK0 A;  4KAY A;  5TJ3 A;  3M8Y A;  5INH A;  3TG0 A;  1E2S P;  2RH6 A;  3LXQ A;  4LRC A;  1B8J A;  1ED8 A;  4UPI A;  1URA A;  4FDI A;  4NWJ A;  2W5S A;  1KHK A;  4TN0 A;  2W5X A;  4CXK A;  2W5R A;  5DLW A;  3CMR A;  4B56 A;  5LRM A;  1KHJ A;  4GTX A;  4LR9 A;  3UN3 A;  5EGH A;  4UPH A;  3BDG B;  5L0B A;  5LIA A;  1E3C P;  3NKR A;  2ANH A;  2W5W A;  2W8D A;  1URB A;  1ALJ A;  2W5V A;  4ZG9 A;  4KAV A;  1E33 P;  2GSN A;  1EJJ A;  1ZEB A;  1SHN A;  2IUC B;  3WAY A;  1ELZ A;  1Y7A A;  1N2L A;  3A52 A;  1O99 A;  3IGZ B;  4GTY A;  4QAX A;  3WAW A;  4KM4 A;  1AJC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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