1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
4LRCA 2ANHA 5INHA 5LQQA 3WBHA 3CMRA 1N2KA 1KH4A 1URAA 1KH5A 1KHNA 3BDHA 5IJQA 3SZYA 3E2DA 1HDHA 4KJDA 3LXQA 1EW2A 3UN3A 1N2LA 1FSUA 5LIAA 2IFYA 4ZG9A 3TX0A 2VQRA 2D1GA 3MK2A 2IUCB 4FDJA 4LR9A 2ZKTA 4UPKA 1Y7AA 1E33P 5C66A 3UO0A 4CXUA 3NKRA 3DYCA 4CXKA 1KH9A 4MY4A 3BDFA 3OT9A 2IUCA 4KAVA 3B5QA 3Q3QA 2GSOA 1ANJA 1SHQA 1Y6VA 2GLQA 1AUKA 4GTXA 5K4PA 3TWZA 2W5SA 4GTWA 3M7VA 3NKPA 1EW9A 3IDDA 2W5RA 3IGZB 4NWJA 5LRNA 1SHNA 4ZG6A 2GSNA 1K7HA 3T01A 1E1ZP 2W5QA 3SZZA 1O98A 1E2SP 4UORA 4MHXA 4TN0A 3WAVA 1B8JA 1ZEBA 2G9YA 4CYRA 3NKMA 2W5VA 3UNYA 1URBA 1KHKA 3M8YA 4LR7A 2GSUA 4UPIA 5TJ3A 4GTYA 3NVLA 3NKOA 4UOOA 5DLTA 3BDGB 4NWXA 3M8WA 5DLWA 1EW8A 3UN5A 4LQYA 1ZEDA 3T02A 5GOVA 4B56A 4N7TA 2XR9A 5L0BA 1ED9A 1AJCA 3M8ZA 4LRBA 1KHLA 2W8SA 5EGEA 3T00A 4CYSA 5L0EA 5GRRA 5LRMA 2GA3A 2XRGA 1O99A 2W5WA 3ED4A 5L0KA 1KH7A 4KJGA 1ELYA 1ALJA 3MK0A 4GTZA 5EGHA 3NKQA 1AJAA 3TG0A 5IJSA 4UPHA 3WAYA 2W5TA 3UN2A 1AJBA 4LR8A 4ZGAA 3WAXA 1EI6A 1HQAA 3WAWA 1P49A 3NKNA 4LRAA 4LRFA 1ALHA 4LR2A 4MIVA 5DLVA 1ELZA 1EQJA 3KD8A 4UOPA 3A52A 3BDGA 4UPLA 2W8DA 5KXAA 2RH6A 4ZG7A 1ALKA 2X98A 1ED8A 1ALIA 1EJJA 2QZUA 5AJ9A 4YR1A 4CXSA 1ANIA 4LREA 4FDIA 4QAXA 1ZEFA 2W5XA 3IGYB 4LRDA 1KHJA 1ELXA 4KM4A 4KAYA 1AJDA 5HRTA 1HJKA 3MK1A 1E3CP 3DPCA
chains in the Genus database with same CATH superfamily
4LRCA 2ANHA 5INHA 5LQQA 3WBHA 3CMRA 1N2KA 1KH4A 1URAA 1KH5A 1KHNA 3BDHA 5IJQA 3SZYA 3E2DA 1HDHA 4KJDA 3LXQA 1EW2A 3UN3A 1N2LA 1FSUA 5LIAA 2IFYA 4ZG9A 3TX0A 2VQRA 2D1GA 3MK2A 2IUCB 4FDJA 4LR9A 2ZKTA 4UPKA 1Y7AA 1E33P 5C66A 3UO0A 4CXUA 3NKRA 3DYCA 4CXKA 1KH9A 4MY4A 3BDFA 3OT9A 2IUCA 4KAVA 3B5QA 3Q3QA 2GSOA 1ANJA 1SHQA 1Y6VA 2GLQA 1AUKA 4GTXA 5K4PA 3TWZA 2W5SA 4GTWA 3M7VA 3NKPA 1EW9A 3IDDA 2W5RA 3IGZB 4NWJA 5LRNA 1SHNA 4ZG6A 2GSNA 1K7HA 3T01A 1E1ZP 2W5QA 3SZZA 1O98A 1E2SP 4UORA 4MHXA 4TN0A 3WAVA 1B8JA 1ZEBA 2G9YA 4CYRA 3NKMA 2W5VA 3UNYA 1URBA 1KHKA 3M8YA 4LR7A 2GSUA 4UPIA 5TJ3A 4GTYA 3NVLA 3NKOA 4UOOA 5DLTA 3BDGB 4NWXA 3M8WA 5DLWA 1EW8A 3UN5A 4LQYA 1ZEDA 3T02A 5GOVA 4B56A 4N7TA 2XR9A 5L0BA 1ED9A 1AJCA 3M8ZA 4LRBA 1KHLA 2W8SA 5EGEA 3T00A 4CYSA 5L0EA 5GRRA 5LRMA 2GA3A 2XRGA 1O99A 2W5WA 3ED4A 5L0KA 1KH7A 4KJGA 1ELYA 1ALJA 3MK0A 4GTZA 5EGHA 3NKQA 1AJAA 3TG0A 5IJSA 4UPHA 3WAYA 2W5TA 3UN2A 1AJBA 4LR8A 4ZGAA 3WAXA 1EI6A 1HQAA 3WAWA 1P49A 3NKNA 4LRAA 4LRFA 1ALHA 4LR2A 4MIVA 5DLVA 1ELZA 1EQJA 3KD8A 4UOPA 3A52A 3BDGA 4UPLA 2W8DA 5KXAA 2RH6A 4ZG7A 1ALKA 2X98A 1ED8A 1ALIA 1EJJA 2QZUA 5AJ9A 4YR1A 4CXSA 1ANIA 4LREA 4FDIA 4QAXA 1ZEFA 2W5XA 3IGYB 4LRDA 1KHJA 1ELXA 4KM4A 4KAYA 1AJDA 5HRTA 1HJKA 3MK1A 1E3CP 3DPCA
chains in the Genus database with same CATH topology
4LRCA 2ANHA 5INHA 5LQQA 3WBHA 3CMRA 1N2KA 1KH4A 1URAA 1KH5A 1KHNA 3BDHA 5IJQA 3SZYA 3E2DA 1HDHA 4KJDA 3LXQA 1EW2A 3UN3A 1N2LA 1FSUA 5LIAA 2IFYA 4ZG9A 3TX0A 2VQRA 2D1GA 3MK2A 2IUCB 4FDJA 4LR9A 2ZKTA 4UPKA 1Y7AA 1E33P 5C66A 3UO0A 4CXUA 3NKRA 3DYCA 4CXKA 1KH9A 4MY4A 3BDFA 3OT9A 2IUCA 4KAVA 3B5QA 3Q3QA 2GSOA 1ANJA 1SHQA 1Y6VA 2GLQA 1AUKA 4GTXA 5K4PA 3TWZA 2W5SA 4GTWA 3M7VA 3NKPA 1EW9A 3IDDA 2W5RA 3IGZB 4NWJA 5LRNA 1SHNA 4ZG6A 2GSNA 1K7HA 3T01A 1E1ZP 2W5QA 3SZZA 1O98A 1E2SP 4UORA 4MHXA 4TN0A 3WAVA 1B8JA 1ZEBA 2G9YA 4CYRA 3NKMA 2W5VA 3UNYA 1URBA 1KHKA 3M8YA 4LR7A 2GSUA 4UPIA 5TJ3A 4GTYA 3NVLA 3NKOA 4UOOA 5DLTA 3BDGB 4NWXA 3M8WA 5DLWA 1EW8A 3UN5A 4LQYA 1ZEDA 3T02A 5GOVA 4B56A 4N7TA 2XR9A 5L0BA 1ED9A 1AJCA 3M8ZA 4LRBA 1KHLA 2W8SA 5EGEA 3T00A 4CYSA 5L0EA 5GRRA 5LRMA 2GA3A 2XRGA 1O99A 2W5WA 3ED4A 5L0KA 1KH7A 4KJGA 1ELYA 1ALJA 3MK0A 4GTZA 5EGHA 3NKQA 1AJAA 3TG0A 5IJSA 4UPHA 3WAYA 2W5TA 3UN2A 1AJBA 4LR8A 4ZGAA 3WAXA 1EI6A 1HQAA 3WAWA 1P49A 3NKNA 4LRAA 4LRFA 1ALHA 4LR2A 4MIVA 5DLVA 1ELZA 1EQJA 3KD8A 4UOPA 3A52A 3BDGA 4UPLA 2W8DA 5KXAA 2RH6A 4ZG7A 1ALKA 2X98A 1ED8A 1ALIA 1EJJA 2QZUA 5AJ9A 4YR1A 4CXSA 1ANIA 4LREA 4FDIA 4QAXA 1ZEFA 2W5XA 3IGYB 4LRDA 1KHJA 1ELXA 4KM4A 4KAYA 1AJDA 5HRTA 1HJKA 3MK1A 1E3CP 3DPCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRC A;  2ANH A;  5INH A;  5LQQ A;  3WBH A;  3CMR A;  1N2K A;  1KH4 A;  1URA A;  1KH5 A;  1KHN A;  3BDH A;  5IJQ A;  3SZY A;  3E2D A;  1HDH A;  4KJD A;  3LXQ A;  1EW2 A;  3UN3 A;  1N2L A;  1FSU A;  5LIA A;  2IFY A;  4ZG9 A;  3TX0 A;  2VQR A;  2D1G A;  3MK2 A;  2IUC B;  4FDJ A;  4LR9 A;  2ZKT A;  4UPK A;  1Y7A A;  1E33 P;  5C66 A;  3UO0 A;  4CXU A;  3NKR A;  3DYC A;  4CXK A;  1KH9 A;  4MY4 A;  3BDF A;  3OT9 A;  2IUC A;  4KAV A;  3B5Q A;  3Q3Q A;  2GSO A;  1ANJ A;  1SHQ A;  1Y6V A;  2GLQ A;  1AUK A;  4GTX A;  5K4P A;  3TWZ A;  2W5S A;  4GTW A;  3M7V A;  3NKP A;  1EW9 A;  3IDD A;  2W5R A;  3IGZ B;  4NWJ A;  5LRN A;  1SHN A;  4ZG6 A;  2GSN A;  1K7H A;  3T01 A;  1E1Z P;  2W5Q A;  3SZZ A;  1O98 A;  1E2S P;  4UOR A;  4MHX A;  4TN0 A;  3WAV A;  1B8J A;  1ZEB A;  2G9Y A;  4CYR A;  3NKM A;  2W5V A;  3UNY A;  1URB A;  1KHK A;  3M8Y A;  4LR7 A;  2GSU A;  4UPI A;  5TJ3 A;  4GTY A;  3NVL A;  3NKO A;  4UOO A;  5DLT A;  3BDG B;  4NWX A;  3M8W A;  5DLW A;  1EW8 A;  3UN5 A;  4LQY A;  1ZED A;  3T02 A;  5GOV A;  4B56 A;  4N7T A;  2XR9 A;  5L0B A;  1ED9 A;  1AJC A;  3M8Z A;  4LRB A;  1KHL A;  2W8S A;  5EGE A;  3T00 A;  4CYS A;  5L0E A;  5GRR A;  5LRM A;  2GA3 A;  2XRG A;  1O99 A;  2W5W A;  3ED4 A;  5L0K A;  1KH7 A;  4KJG A;  1ELY A;  1ALJ A;  3MK0 A;  4GTZ A;  5EGH A;  3NKQ A;  1AJA A;  3TG0 A;  5IJS A;  4UPH A;  3WAY A;  2W5T A;  3UN2 A;  1AJB A;  4LR8 A;  4ZGA A;  3WAX A;  1EI6 A;  1HQA A;  3WAW A;  1P49 A;  3NKN A;  4LRA A;  4LRF A;  1ALH A;  4LR2 A;  4MIV A;  5DLV A;  1ELZ A;  1EQJ A;  3KD8 A;  4UOP A;  3A52 A;  3BDG A;  4UPL A;  2W8D A;  5KXA A;  2RH6 A;  4ZG7 A;  1ALK A;  2X98 A;  1ED8 A;  1ALI A;  1EJJ A;  2QZU A;  5AJ9 A;  4YR1 A;  4CXS A;  1ANI A;  4LRE A;  4FDI A;  4QAX A;  1ZEF A;  2W5X A;  3IGY B;  4LRD A;  1KHJ A;  1ELX A;  4KM4 A;  4KAY A;  1AJD A;  5HRT A;  1HJK A;  3MK1 A;  1E3C P;  3DPC A; 
#chains in the Genus database with same CATH topology
 4LRC A;  2ANH A;  5INH A;  5LQQ A;  3WBH A;  3CMR A;  1N2K A;  1KH4 A;  1URA A;  1KH5 A;  1KHN A;  3BDH A;  5IJQ A;  3SZY A;  3E2D A;  1HDH A;  4KJD A;  3LXQ A;  1EW2 A;  3UN3 A;  1N2L A;  1FSU A;  5LIA A;  2IFY A;  4ZG9 A;  3TX0 A;  2VQR A;  2D1G A;  3MK2 A;  2IUC B;  4FDJ A;  4LR9 A;  2ZKT A;  4UPK A;  1Y7A A;  1E33 P;  5C66 A;  3UO0 A;  4CXU A;  3NKR A;  3DYC A;  4CXK A;  1KH9 A;  4MY4 A;  3BDF A;  3OT9 A;  2IUC A;  4KAV A;  3B5Q A;  3Q3Q A;  2GSO A;  1ANJ A;  1SHQ A;  1Y6V A;  2GLQ A;  1AUK A;  4GTX A;  5K4P A;  3TWZ A;  2W5S A;  4GTW A;  3M7V A;  3NKP A;  1EW9 A;  3IDD A;  2W5R A;  3IGZ B;  4NWJ A;  5LRN A;  1SHN A;  4ZG6 A;  2GSN A;  1K7H A;  3T01 A;  1E1Z P;  2W5Q A;  3SZZ A;  1O98 A;  1E2S P;  4UOR A;  4MHX A;  4TN0 A;  3WAV A;  1B8J A;  1ZEB A;  2G9Y A;  4CYR A;  3NKM A;  2W5V A;  3UNY A;  1URB A;  1KHK A;  3M8Y A;  4LR7 A;  2GSU A;  4UPI A;  5TJ3 A;  4GTY A;  3NVL A;  3NKO A;  4UOO A;  5DLT A;  3BDG B;  4NWX A;  3M8W A;  5DLW A;  1EW8 A;  3UN5 A;  4LQY A;  1ZED A;  3T02 A;  5GOV A;  4B56 A;  4N7T A;  2XR9 A;  5L0B A;  1ED9 A;  1AJC A;  3M8Z A;  4LRB A;  1KHL A;  2W8S A;  5EGE A;  3T00 A;  4CYS A;  5L0E A;  5GRR A;  5LRM A;  2GA3 A;  2XRG A;  1O99 A;  2W5W A;  3ED4 A;  5L0K A;  1KH7 A;  4KJG A;  1ELY A;  1ALJ A;  3MK0 A;  4GTZ A;  5EGH A;  3NKQ A;  1AJA A;  3TG0 A;  5IJS A;  4UPH A;  3WAY A;  2W5T A;  3UN2 A;  1AJB A;  4LR8 A;  4ZGA A;  3WAX A;  1EI6 A;  1HQA A;  3WAW A;  1P49 A;  3NKN A;  4LRA A;  4LRF A;  1ALH A;  4LR2 A;  4MIV A;  5DLV A;  1ELZ A;  1EQJ A;  3KD8 A;  4UOP A;  3A52 A;  3BDG A;  4UPL A;  2W8D A;  5KXA A;  2RH6 A;  4ZG7 A;  1ALK A;  2X98 A;  1ED8 A;  1ALI A;  1EJJ A;  2QZU A;  5AJ9 A;  4YR1 A;  4CXS A;  1ANI A;  4LRE A;  4FDI A;  4QAX A;  1ZEF A;  2W5X A;  3IGY B;  4LRD A;  1KHJ A;  1ELX A;  4KM4 A;  4KAY A;  1AJD A;  5HRT A;  1HJK A;  3MK1 A;  1E3C P;  3DPC A; 
#chains in the Genus database with same CATH homology
 4LRC A;  2ANH A;  5INH A;  5LQQ A;  3WBH A;  3CMR A;  1N2K A;  1KH4 A;  1URA A;  1KH5 A;  1KHN A;  3BDH A;  5IJQ A;  3SZY A;  3E2D A;  1HDH A;  4KJD A;  3LXQ A;  1EW2 A;  3UN3 A;  1N2L A;  1FSU A;  5LIA A;  2IFY A;  4ZG9 A;  3TX0 A;  2VQR A;  2D1G A;  3MK2 A;  2IUC B;  4FDJ A;  4LR9 A;  2ZKT A;  4UPK A;  1Y7A A;  1E33 P;  5C66 A;  3UO0 A;  4CXU A;  3NKR A;  3DYC A;  4CXK A;  1KH9 A;  4MY4 A;  3BDF A;  3OT9 A;  2IUC A;  4KAV A;  3B5Q A;  3Q3Q A;  2GSO A;  1ANJ A;  1SHQ A;  1Y6V A;  2GLQ A;  1AUK A;  4GTX A;  5K4P A;  3TWZ A;  2W5S A;  4GTW A;  3M7V A;  3NKP A;  1EW9 A;  3IDD A;  2W5R A;  3IGZ B;  4NWJ A;  5LRN A;  1SHN A;  4ZG6 A;  2GSN A;  1K7H A;  3T01 A;  1E1Z P;  2W5Q A;  3SZZ A;  1O98 A;  1E2S P;  4UOR A;  4MHX A;  4TN0 A;  3WAV A;  1B8J A;  1ZEB A;  2G9Y A;  4CYR A;  3NKM A;  2W5V A;  3UNY A;  1URB A;  1KHK A;  3M8Y A;  4LR7 A;  2GSU A;  4UPI A;  5TJ3 A;  4GTY A;  3NVL A;  3NKO A;  4UOO A;  5DLT A;  3BDG B;  4NWX A;  3M8W A;  5DLW A;  1EW8 A;  3UN5 A;  4LQY A;  1ZED A;  3T02 A;  5GOV A;  4B56 A;  4N7T A;  2XR9 A;  5L0B A;  1ED9 A;  1AJC A;  3M8Z A;  4LRB A;  1KHL A;  2W8S A;  5EGE A;  3T00 A;  4CYS A;  5L0E A;  5GRR A;  5LRM A;  2GA3 A;  2XRG A;  1O99 A;  2W5W A;  3ED4 A;  5L0K A;  1KH7 A;  4KJG A;  1ELY A;  1ALJ A;  3MK0 A;  4GTZ A;  5EGH A;  3NKQ A;  1AJA A;  3TG0 A;  5IJS A;  4UPH A;  3WAY A;  2W5T A;  3UN2 A;  1AJB A;  4LR8 A;  4ZGA A;  3WAX A;  1EI6 A;  1HQA A;  3WAW A;  1P49 A;  3NKN A;  4LRA A;  4LRF A;  1ALH A;  4LR2 A;  4MIV A;  5DLV A;  1ELZ A;  1EQJ A;  3KD8 A;  4UOP A;  3A52 A;  3BDG A;  4UPL A;  2W8D A;  5KXA A;  2RH6 A;  4ZG7 A;  1ALK A;  2X98 A;  1ED8 A;  1ALI A;  1EJJ A;  2QZU A;  5AJ9 A;  4YR1 A;  4CXS A;  1ANI A;  4LRE A;  4FDI A;  4QAX A;  1ZEF A;  2W5X A;  3IGY B;  4LRD A;  1KHJ A;  1ELX A;  4KM4 A;  4KAY A;  1AJD A;  5HRT A;  1HJK A;  3MK1 A;  1E3C P;  3DPC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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