1KHKA

E. coli alkaline phosphatase mutant (d153hd330n)
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
444
structure length
444
Chain Sequence
b'VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline Phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 149
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khkA00
4UPKA 1HDHA 2W5WA 2IUCA 4GTXA 4LRCA 4FDIA 1K7HA 4LR8A 3T00A 3T02A 5IJSA 1ZEBA 1EJJA 3BDGA 4UPLA 3UO0A 1ALJA 1EI6A 3IDDA 2XRGA 5L0BA 4YR1A 1KHKA 2VQRA 1E33P 3BDHA 3CMRA 1O99A 1KHJA 1N2KA 1ZEFA 3ED4A 1EW9A 5K4PA 1B8JA 3WAVA 5IJQA 3NKRA 3UN5A 4LR2A 4ZGAA 1AJAA 1P49A 5GOVA 4MHXA 1AUKA 2XR9A 1KH5A 2ANHA 5LRMA 3OT9A 3DPCA 4KJGA 4LR9A 5DLWA 5L0KA 1KH4A 1ELZA 3MK0A 4KAVA 3SZYA 4GTYA 3NKOA 4UOPA 3T01A 1O98A 3UNYA 4LREA 4LRDA 3A52A 1KH9A 3DYCA 3IGYB 3M7VA 1SHQA 4LQYA 4GTWA 4N7TA 1ED9A 4CYSA 1HQAA 3IGZB 5EGHA 1E3CP 3LXQA 3NKNA 4UPIA 2QZUA 2GSUA 2W5RA 4UPHA 5GRRA 4QAXA 1ANIA 4NWXA 2X98A 4UORA 2ZKTA 1Y7AA 4LRAA 5INHA 3UN3A 5C66A 1AJCA 1EQJA 3MK2A 2W5SA 1EW2A 1N2LA 1E2SP 4ZG7A 2W5TA 4CXKA 1AJBA 3NVLA 2GSNA 5EGEA 1HJKA 3B5QA 3MK1A 3M8YA 4LR7A 3UN2A 1SHNA 1ALKA 5LIAA 2IUCB 5AJ9A 1URAA 3NKPA 1Y6VA 4CYRA 1KHLA 2D1GA 4LRFA 2W8SA 1ELXA 5LRNA 4CXSA 1E1ZP 2RH6A 1EW8A 3E2DA 4NWJA 4CXUA 4GTZA 4UOOA 3TX0A 1KH7A 2W8DA 2GSOA 2G9YA 3TWZA 1KHNA 5DLVA 5LQQA 4KJDA 3BDFA 2W5XA 1ELYA 4TN0A 3M8WA 3WAXA 4ZG6A 3WAWA 4B56A 3TG0A 2GLQA 1ALIA 5TJ3A 4MY4A 1ZEDA 3NKQA 3BDGB 4LRBA 1ED8A 4KAYA 1URBA 1AJDA 3SZZA 3WBHA 1ANJA 4FDJA 2IFYA 3KD8A 5KXAA 3Q3QA 4MIVA 5DLTA 4KM4A 1FSUA 2W5QA 4ZG9A 3M8ZA 2GA3A 1ALHA 3NKMA 3WAYA 2W5VA 5HRTA 5L0EA
chains in the Genus database with same CATH superfamily
4UPKA 1HDHA 2W5WA 2IUCA 4GTXA 4LRCA 4FDIA 1K7HA 4LR8A 3T00A 3T02A 5IJSA 1ZEBA 1EJJA 3BDGA 4UPLA 3UO0A 1ALJA 1EI6A 3IDDA 2XRGA 5L0BA 4YR1A 1KHKA 2VQRA 1E33P 3BDHA 3CMRA 1O99A 1KHJA 1N2KA 1ZEFA 3ED4A 1EW9A 5K4PA 1B8JA 3WAVA 5IJQA 3NKRA 3UN5A 4LR2A 4ZGAA 1AJAA 1P49A 5GOVA 4MHXA 1AUKA 2XR9A 1KH5A 2ANHA 5LRMA 3OT9A 3DPCA 4KJGA 4LR9A 5DLWA 5L0KA 1KH4A 1ELZA 3MK0A 4KAVA 3SZYA 4GTYA 3NKOA 4UOPA 3T01A 1O98A 3UNYA 4LREA 4LRDA 3A52A 1KH9A 3DYCA 3IGYB 3M7VA 1SHQA 4LQYA 4GTWA 4N7TA 1ED9A 4CYSA 1HQAA 3IGZB 5EGHA 1E3CP 3LXQA 3NKNA 4UPIA 2QZUA 2GSUA 2W5RA 4UPHA 5GRRA 4QAXA 1ANIA 4NWXA 2X98A 4UORA 2ZKTA 1Y7AA 4LRAA 5INHA 3UN3A 5C66A 1AJCA 1EQJA 3MK2A 2W5SA 1EW2A 1N2LA 1E2SP 4ZG7A 2W5TA 4CXKA 1AJBA 3NVLA 2GSNA 5EGEA 1HJKA 3B5QA 3MK1A 3M8YA 4LR7A 3UN2A 1SHNA 1ALKA 5LIAA 2IUCB 5AJ9A 1URAA 3NKPA 1Y6VA 4CYRA 1KHLA 2D1GA 4LRFA 2W8SA 1ELXA 5LRNA 4CXSA 1E1ZP 2RH6A 1EW8A 3E2DA 4NWJA 4CXUA 4GTZA 4UOOA 3TX0A 1KH7A 2W8DA 2GSOA 2G9YA 3TWZA 1KHNA 5DLVA 5LQQA 4KJDA 3BDFA 2W5XA 1ELYA 4TN0A 3M8WA 3WAXA 4ZG6A 3WAWA 4B56A 3TG0A 2GLQA 1ALIA 5TJ3A 4MY4A 1ZEDA 3NKQA 3BDGB 4LRBA 1ED8A 4KAYA 1URBA 1AJDA 3SZZA 3WBHA 1ANJA 4FDJA 2IFYA 3KD8A 5KXAA 3Q3QA 4MIVA 5DLTA 4KM4A 1FSUA 2W5QA 4ZG9A 3M8ZA 2GA3A 1ALHA 3NKMA 3WAYA 2W5VA 5HRTA 5L0EA
chains in the Genus database with same CATH topology
4UPKA 1HDHA 2W5WA 2IUCA 4GTXA 4LRCA 4FDIA 1K7HA 4LR8A 3T00A 3T02A 5IJSA 1ZEBA 1EJJA 3BDGA 4UPLA 3UO0A 1ALJA 1EI6A 3IDDA 2XRGA 5L0BA 4YR1A 1KHKA 2VQRA 1E33P 3BDHA 3CMRA 1O99A 1KHJA 1N2KA 1ZEFA 3ED4A 1EW9A 5K4PA 1B8JA 3WAVA 5IJQA 3NKRA 3UN5A 4LR2A 4ZGAA 1AJAA 1P49A 5GOVA 4MHXA 1AUKA 2XR9A 1KH5A 2ANHA 5LRMA 3OT9A 3DPCA 4KJGA 4LR9A 5DLWA 5L0KA 1KH4A 1ELZA 3MK0A 4KAVA 3SZYA 4GTYA 3NKOA 4UOPA 3T01A 1O98A 3UNYA 4LREA 4LRDA 3A52A 1KH9A 3DYCA 3IGYB 3M7VA 1SHQA 4LQYA 4GTWA 4N7TA 1ED9A 4CYSA 1HQAA 3IGZB 5EGHA 1E3CP 3LXQA 3NKNA 4UPIA 2QZUA 2GSUA 2W5RA 4UPHA 5GRRA 4QAXA 1ANIA 4NWXA 2X98A 4UORA 2ZKTA 1Y7AA 4LRAA 5INHA 3UN3A 5C66A 1AJCA 1EQJA 3MK2A 2W5SA 1EW2A 1N2LA 1E2SP 4ZG7A 2W5TA 4CXKA 1AJBA 3NVLA 2GSNA 5EGEA 1HJKA 3B5QA 3MK1A 3M8YA 4LR7A 3UN2A 1SHNA 1ALKA 5LIAA 2IUCB 5AJ9A 1URAA 3NKPA 1Y6VA 4CYRA 1KHLA 2D1GA 4LRFA 2W8SA 1ELXA 5LRNA 4CXSA 1E1ZP 2RH6A 1EW8A 3E2DA 4NWJA 4CXUA 4GTZA 4UOOA 3TX0A 1KH7A 2W8DA 2GSOA 2G9YA 3TWZA 1KHNA 5DLVA 5LQQA 4KJDA 3BDFA 2W5XA 1ELYA 4TN0A 3M8WA 3WAXA 4ZG6A 3WAWA 4B56A 3TG0A 2GLQA 1ALIA 5TJ3A 4MY4A 1ZEDA 3NKQA 3BDGB 4LRBA 1ED8A 4KAYA 1URBA 1AJDA 3SZZA 3WBHA 1ANJA 4FDJA 2IFYA 3KD8A 5KXAA 3Q3QA 4MIVA 5DLTA 4KM4A 1FSUA 2W5QA 4ZG9A 3M8ZA 2GA3A 1ALHA 3NKMA 3WAYA 2W5VA 5HRTA 5L0EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UPK A;  1HDH A;  2W5W A;  2IUC A;  4GTX A;  4LRC A;  4FDI A;  1K7H A;  4LR8 A;  3T00 A;  3T02 A;  5IJS A;  1ZEB A;  1EJJ A;  3BDG A;  4UPL A;  3UO0 A;  1ALJ A;  1EI6 A;  3IDD A;  2XRG A;  5L0B A;  4YR1 A;  1KHK A;  2VQR A;  1E33 P;  3BDH A;  3CMR A;  1O99 A;  1KHJ A;  1N2K A;  1ZEF A;  3ED4 A;  1EW9 A;  5K4P A;  1B8J A;  3WAV A;  5IJQ A;  3NKR A;  3UN5 A;  4LR2 A;  4ZGA A;  1AJA A;  1P49 A;  5GOV A;  4MHX A;  1AUK A;  2XR9 A;  1KH5 A;  2ANH A;  5LRM A;  3OT9 A;  3DPC A;  4KJG A;  4LR9 A;  5DLW A;  5L0K A;  1KH4 A;  1ELZ A;  3MK0 A;  4KAV A;  3SZY A;  4GTY A;  3NKO A;  4UOP A;  3T01 A;  1O98 A;  3UNY A;  4LRE A;  4LRD A;  3A52 A;  1KH9 A;  3DYC A;  3IGY B;  3M7V A;  1SHQ A;  4LQY A;  4GTW A;  4N7T A;  1ED9 A;  4CYS A;  1HQA A;  3IGZ B;  5EGH A;  1E3C P;  3LXQ A;  3NKN A;  4UPI A;  2QZU A;  2GSU A;  2W5R A;  4UPH A;  5GRR A;  4QAX A;  1ANI A;  4NWX A;  2X98 A;  4UOR A;  2ZKT A;  1Y7A A;  4LRA A;  5INH A;  3UN3 A;  5C66 A;  1AJC A;  1EQJ A;  3MK2 A;  2W5S A;  1EW2 A;  1N2L A;  1E2S P;  4ZG7 A;  2W5T A;  4CXK A;  1AJB A;  3NVL A;  2GSN A;  5EGE A;  1HJK A;  3B5Q A;  3MK1 A;  3M8Y A;  4LR7 A;  3UN2 A;  1SHN A;  1ALK A;  5LIA A;  2IUC B;  5AJ9 A;  1URA A;  3NKP A;  1Y6V A;  4CYR A;  1KHL A;  2D1G A;  4LRF A;  2W8S A;  1ELX A;  5LRN A;  4CXS A;  1E1Z P;  2RH6 A;  1EW8 A;  3E2D A;  4NWJ A;  4CXU A;  4GTZ A;  4UOO A;  3TX0 A;  1KH7 A;  2W8D A;  2GSO A;  2G9Y A;  3TWZ A;  1KHN A;  5DLV A;  5LQQ A;  4KJD A;  3BDF A;  2W5X A;  1ELY A;  4TN0 A;  3M8W A;  3WAX A;  4ZG6 A;  3WAW A;  4B56 A;  3TG0 A;  2GLQ A;  1ALI A;  5TJ3 A;  4MY4 A;  1ZED A;  3NKQ A;  3BDG B;  4LRB A;  1ED8 A;  4KAY A;  1URB A;  1AJD A;  3SZZ A;  3WBH A;  1ANJ A;  4FDJ A;  2IFY A;  3KD8 A;  5KXA A;  3Q3Q A;  4MIV A;  5DLT A;  4KM4 A;  1FSU A;  2W5Q A;  4ZG9 A;  3M8Z A;  2GA3 A;  1ALH A;  3NKM A;  3WAY A;  2W5V A;  5HRT A;  5L0E A; 
#chains in the Genus database with same CATH topology
 4UPK A;  1HDH A;  2W5W A;  2IUC A;  4GTX A;  4LRC A;  4FDI A;  1K7H A;  4LR8 A;  3T00 A;  3T02 A;  5IJS A;  1ZEB A;  1EJJ A;  3BDG A;  4UPL A;  3UO0 A;  1ALJ A;  1EI6 A;  3IDD A;  2XRG A;  5L0B A;  4YR1 A;  1KHK A;  2VQR A;  1E33 P;  3BDH A;  3CMR A;  1O99 A;  1KHJ A;  1N2K A;  1ZEF A;  3ED4 A;  1EW9 A;  5K4P A;  1B8J A;  3WAV A;  5IJQ A;  3NKR A;  3UN5 A;  4LR2 A;  4ZGA A;  1AJA A;  1P49 A;  5GOV A;  4MHX A;  1AUK A;  2XR9 A;  1KH5 A;  2ANH A;  5LRM A;  3OT9 A;  3DPC A;  4KJG A;  4LR9 A;  5DLW A;  5L0K A;  1KH4 A;  1ELZ A;  3MK0 A;  4KAV A;  3SZY A;  4GTY A;  3NKO A;  4UOP A;  3T01 A;  1O98 A;  3UNY A;  4LRE A;  4LRD A;  3A52 A;  1KH9 A;  3DYC A;  3IGY B;  3M7V A;  1SHQ A;  4LQY A;  4GTW A;  4N7T A;  1ED9 A;  4CYS A;  1HQA A;  3IGZ B;  5EGH A;  1E3C P;  3LXQ A;  3NKN A;  4UPI A;  2QZU A;  2GSU A;  2W5R A;  4UPH A;  5GRR A;  4QAX A;  1ANI A;  4NWX A;  2X98 A;  4UOR A;  2ZKT A;  1Y7A A;  4LRA A;  5INH A;  3UN3 A;  5C66 A;  1AJC A;  1EQJ A;  3MK2 A;  2W5S A;  1EW2 A;  1N2L A;  1E2S P;  4ZG7 A;  2W5T A;  4CXK A;  1AJB A;  3NVL A;  2GSN A;  5EGE A;  1HJK A;  3B5Q A;  3MK1 A;  3M8Y A;  4LR7 A;  3UN2 A;  1SHN A;  1ALK A;  5LIA A;  2IUC B;  5AJ9 A;  1URA A;  3NKP A;  1Y6V A;  4CYR A;  1KHL A;  2D1G A;  4LRF A;  2W8S A;  1ELX A;  5LRN A;  4CXS A;  1E1Z P;  2RH6 A;  1EW8 A;  3E2D A;  4NWJ A;  4CXU A;  4GTZ A;  4UOO A;  3TX0 A;  1KH7 A;  2W8D A;  2GSO A;  2G9Y A;  3TWZ A;  1KHN A;  5DLV A;  5LQQ A;  4KJD A;  3BDF A;  2W5X A;  1ELY A;  4TN0 A;  3M8W A;  3WAX A;  4ZG6 A;  3WAW A;  4B56 A;  3TG0 A;  2GLQ A;  1ALI A;  5TJ3 A;  4MY4 A;  1ZED A;  3NKQ A;  3BDG B;  4LRB A;  1ED8 A;  4KAY A;  1URB A;  1AJD A;  3SZZ A;  3WBH A;  1ANJ A;  4FDJ A;  2IFY A;  3KD8 A;  5KXA A;  3Q3Q A;  4MIV A;  5DLT A;  4KM4 A;  1FSU A;  2W5Q A;  4ZG9 A;  3M8Z A;  2GA3 A;  1ALH A;  3NKM A;  3WAY A;  2W5V A;  5HRT A;  5L0E A; 
#chains in the Genus database with same CATH homology
 4UPK A;  1HDH A;  2W5W A;  2IUC A;  4GTX A;  4LRC A;  4FDI A;  1K7H A;  4LR8 A;  3T00 A;  3T02 A;  5IJS A;  1ZEB A;  1EJJ A;  3BDG A;  4UPL A;  3UO0 A;  1ALJ A;  1EI6 A;  3IDD A;  2XRG A;  5L0B A;  4YR1 A;  1KHK A;  2VQR A;  1E33 P;  3BDH A;  3CMR A;  1O99 A;  1KHJ A;  1N2K A;  1ZEF A;  3ED4 A;  1EW9 A;  5K4P A;  1B8J A;  3WAV A;  5IJQ A;  3NKR A;  3UN5 A;  4LR2 A;  4ZGA A;  1AJA A;  1P49 A;  5GOV A;  4MHX A;  1AUK A;  2XR9 A;  1KH5 A;  2ANH A;  5LRM A;  3OT9 A;  3DPC A;  4KJG A;  4LR9 A;  5DLW A;  5L0K A;  1KH4 A;  1ELZ A;  3MK0 A;  4KAV A;  3SZY A;  4GTY A;  3NKO A;  4UOP A;  3T01 A;  1O98 A;  3UNY A;  4LRE A;  4LRD A;  3A52 A;  1KH9 A;  3DYC A;  3IGY B;  3M7V A;  1SHQ A;  4LQY A;  4GTW A;  4N7T A;  1ED9 A;  4CYS A;  1HQA A;  3IGZ B;  5EGH A;  1E3C P;  3LXQ A;  3NKN A;  4UPI A;  2QZU A;  2GSU A;  2W5R A;  4UPH A;  5GRR A;  4QAX A;  1ANI A;  4NWX A;  2X98 A;  4UOR A;  2ZKT A;  1Y7A A;  4LRA A;  5INH A;  3UN3 A;  5C66 A;  1AJC A;  1EQJ A;  3MK2 A;  2W5S A;  1EW2 A;  1N2L A;  1E2S P;  4ZG7 A;  2W5T A;  4CXK A;  1AJB A;  3NVL A;  2GSN A;  5EGE A;  1HJK A;  3B5Q A;  3MK1 A;  3M8Y A;  4LR7 A;  3UN2 A;  1SHN A;  1ALK A;  5LIA A;  2IUC B;  5AJ9 A;  1URA A;  3NKP A;  1Y6V A;  4CYR A;  1KHL A;  2D1G A;  4LRF A;  2W8S A;  1ELX A;  5LRN A;  4CXS A;  1E1Z P;  2RH6 A;  1EW8 A;  3E2D A;  4NWJ A;  4CXU A;  4GTZ A;  4UOO A;  3TX0 A;  1KH7 A;  2W8D A;  2GSO A;  2G9Y A;  3TWZ A;  1KHN A;  5DLV A;  5LQQ A;  4KJD A;  3BDF A;  2W5X A;  1ELY A;  4TN0 A;  3M8W A;  3WAX A;  4ZG6 A;  3WAW A;  4B56 A;  3TG0 A;  2GLQ A;  1ALI A;  5TJ3 A;  4MY4 A;  1ZED A;  3NKQ A;  3BDG B;  4LRB A;  1ED8 A;  4KAY A;  1URB A;  1AJD A;  3SZZ A;  3WBH A;  1ANJ A;  4FDJ A;  2IFY A;  3KD8 A;  5KXA A;  3Q3Q A;  4MIV A;  5DLT A;  4KM4 A;  1FSU A;  2W5Q A;  4ZG9 A;  3M8Z A;  2GA3 A;  1ALH A;  3NKM A;  3WAY A;  2W5V A;  5HRT A;  5L0E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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