1KHLA

E. coli alkaline phosphatase mutant (d153hd330n) complex with phosphate
Total Genus 150
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
150
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule keywords Alkaline Phosphatase
molecule tags Hydrolase
source organism Escherichia coli
total genus 150
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khlA00
5DLWA 5LRMA 5L0BA 4GTWA 1ANJA 4UORA 3DPCA 3M8WA 4GTYA 1ELZA 1KHJA 2IUCA 3NVLA 3NKOA 1AJCA 4CXKA 3UN2A 1ZEDA 4QAXA 2GSUA 2XR9A 2X98A 2W5TA 2GSNA 1FSUA 1ELXA 3UN3A 5L0KA 1Y6VA 5IJQA 3T01A 3NKRA 1AUKA 4GTZA 2W5XA 1ALJA 4CYRA 4CYSA 3DYCA 1E1ZP 1EI6A 4LR7A 4LRBA 3WAYA 2W5SA 2IFYA 4UPLA 4MY4A 4FDJA 2GSOA 5GOVA 3MK0A 4LRFA 1ALKA 1EQJA 3OT9A 4ZGAA 3NKQA 1KHKA 3NKPA 1URBA 5HRTA 1E33P 1AJBA 3UO0A 1KH7A 4CXUA 2RH6A 1B8JA 3MK2A 3WAXA 1K7HA 4UPHA 4KJGA 4UPIA 4ZG9A 1E3CP 2ZKTA 4CXSA 3CMRA 5DLVA 1N2KA 5LRNA 1SHQA 2G9YA 4UOPA 1ZEBA 4MIVA 1EW9A 2GA3A 3IGYB 4LRDA 5EGHA 1N2LA 2W8DA 1URAA 2QZUA 2W5QA 4FDIA 1EJJA 4LR9A 3MK1A 2W8SA 4NWJA 4KM4A 2D1GA 5LQQA 1ED8A 1KHLA 4ZG7A 2W5WA 5LIAA 1AJDA 1HQAA 4UPKA 1KH4A 5DLTA 4LR2A 3Q3QA 1KH5A 3NKMA 4ZG6A 1AJAA 3WAVA 1ALIA 3BDGB 2W5RA 1E2SP 4LREA 4GTXA 3A52A 2ANHA 3TG0A 5C66A 1ED9A 4LRAA 1KH9A 3E2DA 2XRGA 1O98A 4B56A 3UN5A 1SHNA 4LRCA 5TJ3A 3TWZA 2W5VA 3M8YA 3SZYA 3M8ZA 3NKNA 5L0EA 3M7VA 3IDDA 4N7TA 4NWXA 1ALHA 4LR8A 3TX0A 4MHXA 2IUCB 3BDGA 1ANIA 3ED4A 1P49A 1Y7AA 4KAVA 5GRRA 1EW8A 3BDFA 5K4PA 4YR1A 1O99A 3T00A 5INHA 3UNYA 4TN0A 3LXQA 3KD8A 3WAWA 3B5QA 5AJ9A 1EW2A 4UOOA 1ELYA 1ZEFA 2VQRA 2GLQA 3SZZA 5IJSA 3IGZB 3BDHA 1KHNA 4KJDA 5KXAA 1HDHA 5EGEA 3WBHA 4LQYA 4KAYA 3T02A 1HJKA
chains in the Genus database with same CATH superfamily
5DLWA 5LRMA 5L0BA 4GTWA 1ANJA 4UORA 3DPCA 3M8WA 4GTYA 1ELZA 1KHJA 2IUCA 3NVLA 3NKOA 1AJCA 4CXKA 3UN2A 1ZEDA 4QAXA 2GSUA 2XR9A 2X98A 2W5TA 2GSNA 1FSUA 1ELXA 3UN3A 5L0KA 1Y6VA 5IJQA 3T01A 3NKRA 1AUKA 4GTZA 2W5XA 1ALJA 4CYRA 4CYSA 3DYCA 1E1ZP 1EI6A 4LR7A 4LRBA 3WAYA 2W5SA 2IFYA 4UPLA 4MY4A 4FDJA 2GSOA 5GOVA 3MK0A 4LRFA 1ALKA 1EQJA 3OT9A 4ZGAA 3NKQA 1KHKA 3NKPA 1URBA 5HRTA 1E33P 1AJBA 3UO0A 1KH7A 4CXUA 2RH6A 1B8JA 3MK2A 3WAXA 1K7HA 4UPHA 4KJGA 4UPIA 4ZG9A 1E3CP 2ZKTA 4CXSA 3CMRA 5DLVA 1N2KA 5LRNA 1SHQA 2G9YA 4UOPA 1ZEBA 4MIVA 1EW9A 2GA3A 3IGYB 4LRDA 5EGHA 1N2LA 2W8DA 1URAA 2QZUA 2W5QA 4FDIA 1EJJA 4LR9A 3MK1A 2W8SA 4NWJA 4KM4A 2D1GA 5LQQA 1ED8A 1KHLA 4ZG7A 2W5WA 5LIAA 1AJDA 1HQAA 4UPKA 1KH4A 5DLTA 4LR2A 3Q3QA 1KH5A 3NKMA 4ZG6A 1AJAA 3WAVA 1ALIA 3BDGB 2W5RA 1E2SP 4LREA 4GTXA 3A52A 2ANHA 3TG0A 5C66A 1ED9A 4LRAA 1KH9A 3E2DA 2XRGA 1O98A 4B56A 3UN5A 1SHNA 4LRCA 5TJ3A 3TWZA 2W5VA 3M8YA 3SZYA 3M8ZA 3NKNA 5L0EA 3M7VA 3IDDA 4N7TA 4NWXA 1ALHA 4LR8A 3TX0A 4MHXA 2IUCB 3BDGA 1ANIA 3ED4A 1P49A 1Y7AA 4KAVA 5GRRA 1EW8A 3BDFA 5K4PA 4YR1A 1O99A 3T00A 5INHA 3UNYA 4TN0A 3LXQA 3KD8A 3WAWA 3B5QA 5AJ9A 1EW2A 4UOOA 1ELYA 1ZEFA 2VQRA 2GLQA 3SZZA 5IJSA 3IGZB 3BDHA 1KHNA 4KJDA 5KXAA 1HDHA 5EGEA 3WBHA 4LQYA 4KAYA 3T02A 1HJKA
chains in the Genus database with same CATH topology
5DLWA 5LRMA 5L0BA 4GTWA 1ANJA 4UORA 3DPCA 3M8WA 4GTYA 1ELZA 1KHJA 2IUCA 3NVLA 3NKOA 1AJCA 4CXKA 3UN2A 1ZEDA 4QAXA 2GSUA 2XR9A 2X98A 2W5TA 2GSNA 1FSUA 1ELXA 3UN3A 5L0KA 1Y6VA 5IJQA 3T01A 3NKRA 1AUKA 4GTZA 2W5XA 1ALJA 4CYRA 4CYSA 3DYCA 1E1ZP 1EI6A 4LR7A 4LRBA 3WAYA 2W5SA 2IFYA 4UPLA 4MY4A 4FDJA 2GSOA 5GOVA 3MK0A 4LRFA 1ALKA 1EQJA 3OT9A 4ZGAA 3NKQA 1KHKA 3NKPA 1URBA 5HRTA 1E33P 1AJBA 3UO0A 1KH7A 4CXUA 2RH6A 1B8JA 3MK2A 3WAXA 1K7HA 4UPHA 4KJGA 4UPIA 4ZG9A 1E3CP 2ZKTA 4CXSA 3CMRA 5DLVA 1N2KA 5LRNA 1SHQA 2G9YA 4UOPA 1ZEBA 4MIVA 1EW9A 2GA3A 3IGYB 4LRDA 5EGHA 1N2LA 2W8DA 1URAA 2QZUA 2W5QA 4FDIA 1EJJA 4LR9A 3MK1A 2W8SA 4NWJA 4KM4A 2D1GA 5LQQA 1ED8A 1KHLA 4ZG7A 2W5WA 5LIAA 1AJDA 1HQAA 4UPKA 1KH4A 5DLTA 4LR2A 3Q3QA 1KH5A 3NKMA 4ZG6A 1AJAA 3WAVA 1ALIA 3BDGB 2W5RA 1E2SP 4LREA 4GTXA 3A52A 2ANHA 3TG0A 5C66A 1ED9A 4LRAA 1KH9A 3E2DA 2XRGA 1O98A 4B56A 3UN5A 1SHNA 4LRCA 5TJ3A 3TWZA 2W5VA 3M8YA 3SZYA 3M8ZA 3NKNA 5L0EA 3M7VA 3IDDA 4N7TA 4NWXA 1ALHA 4LR8A 3TX0A 4MHXA 2IUCB 3BDGA 1ANIA 3ED4A 1P49A 1Y7AA 4KAVA 5GRRA 1EW8A 3BDFA 5K4PA 4YR1A 1O99A 3T00A 5INHA 3UNYA 4TN0A 3LXQA 3KD8A 3WAWA 3B5QA 5AJ9A 1EW2A 4UOOA 1ELYA 1ZEFA 2VQRA 2GLQA 3SZZA 5IJSA 3IGZB 3BDHA 1KHNA 4KJDA 5KXAA 1HDHA 5EGEA 3WBHA 4LQYA 4KAYA 3T02A 1HJKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DLW A;  5LRM A;  5L0B A;  4GTW A;  1ANJ A;  4UOR A;  3DPC A;  3M8W A;  4GTY A;  1ELZ A;  1KHJ A;  2IUC A;  3NVL A;  3NKO A;  1AJC A;  4CXK A;  3UN2 A;  1ZED A;  4QAX A;  2GSU A;  2XR9 A;  2X98 A;  2W5T A;  2GSN A;  1FSU A;  1ELX A;  3UN3 A;  5L0K A;  1Y6V A;  5IJQ A;  3T01 A;  3NKR A;  1AUK A;  4GTZ A;  2W5X A;  1ALJ A;  4CYR A;  4CYS A;  3DYC A;  1E1Z P;  1EI6 A;  4LR7 A;  4LRB A;  3WAY A;  2W5S A;  2IFY A;  4UPL A;  4MY4 A;  4FDJ A;  2GSO A;  5GOV A;  3MK0 A;  4LRF A;  1ALK A;  1EQJ A;  3OT9 A;  4ZGA A;  3NKQ A;  1KHK A;  3NKP A;  1URB A;  5HRT A;  1E33 P;  1AJB A;  3UO0 A;  1KH7 A;  4CXU A;  2RH6 A;  1B8J A;  3MK2 A;  3WAX A;  1K7H A;  4UPH A;  4KJG A;  4UPI A;  4ZG9 A;  1E3C P;  2ZKT A;  4CXS A;  3CMR A;  5DLV A;  1N2K A;  5LRN A;  1SHQ A;  2G9Y A;  4UOP A;  1ZEB A;  4MIV A;  1EW9 A;  2GA3 A;  3IGY B;  4LRD A;  5EGH A;  1N2L A;  2W8D A;  1URA A;  2QZU A;  2W5Q A;  4FDI A;  1EJJ A;  4LR9 A;  3MK1 A;  2W8S A;  4NWJ A;  4KM4 A;  2D1G A;  5LQQ A;  1ED8 A;  1KHL A;  4ZG7 A;  2W5W A;  5LIA A;  1AJD A;  1HQA A;  4UPK A;  1KH4 A;  5DLT A;  4LR2 A;  3Q3Q A;  1KH5 A;  3NKM A;  4ZG6 A;  1AJA A;  3WAV A;  1ALI A;  3BDG B;  2W5R A;  1E2S P;  4LRE A;  4GTX A;  3A52 A;  2ANH A;  3TG0 A;  5C66 A;  1ED9 A;  4LRA A;  1KH9 A;  3E2D A;  2XRG A;  1O98 A;  4B56 A;  3UN5 A;  1SHN A;  4LRC A;  5TJ3 A;  3TWZ A;  2W5V A;  3M8Y A;  3SZY A;  3M8Z A;  3NKN A;  5L0E A;  3M7V A;  3IDD A;  4N7T A;  4NWX A;  1ALH A;  4LR8 A;  3TX0 A;  4MHX A;  2IUC B;  3BDG A;  1ANI A;  3ED4 A;  1P49 A;  1Y7A A;  4KAV A;  5GRR A;  1EW8 A;  3BDF A;  5K4P A;  4YR1 A;  1O99 A;  3T00 A;  5INH A;  3UNY A;  4TN0 A;  3LXQ A;  3KD8 A;  3WAW A;  3B5Q A;  5AJ9 A;  1EW2 A;  4UOO A;  1ELY A;  1ZEF A;  2VQR A;  2GLQ A;  3SZZ A;  5IJS A;  3IGZ B;  3BDH A;  1KHN A;  4KJD A;  5KXA A;  1HDH A;  5EGE A;  3WBH A;  4LQY A;  4KAY A;  3T02 A;  1HJK A; 
#chains in the Genus database with same CATH topology
 5DLW A;  5LRM A;  5L0B A;  4GTW A;  1ANJ A;  4UOR A;  3DPC A;  3M8W A;  4GTY A;  1ELZ A;  1KHJ A;  2IUC A;  3NVL A;  3NKO A;  1AJC A;  4CXK A;  3UN2 A;  1ZED A;  4QAX A;  2GSU A;  2XR9 A;  2X98 A;  2W5T A;  2GSN A;  1FSU A;  1ELX A;  3UN3 A;  5L0K A;  1Y6V A;  5IJQ A;  3T01 A;  3NKR A;  1AUK A;  4GTZ A;  2W5X A;  1ALJ A;  4CYR A;  4CYS A;  3DYC A;  1E1Z P;  1EI6 A;  4LR7 A;  4LRB A;  3WAY A;  2W5S A;  2IFY A;  4UPL A;  4MY4 A;  4FDJ A;  2GSO A;  5GOV A;  3MK0 A;  4LRF A;  1ALK A;  1EQJ A;  3OT9 A;  4ZGA A;  3NKQ A;  1KHK A;  3NKP A;  1URB A;  5HRT A;  1E33 P;  1AJB A;  3UO0 A;  1KH7 A;  4CXU A;  2RH6 A;  1B8J A;  3MK2 A;  3WAX A;  1K7H A;  4UPH A;  4KJG A;  4UPI A;  4ZG9 A;  1E3C P;  2ZKT A;  4CXS A;  3CMR A;  5DLV A;  1N2K A;  5LRN A;  1SHQ A;  2G9Y A;  4UOP A;  1ZEB A;  4MIV A;  1EW9 A;  2GA3 A;  3IGY B;  4LRD A;  5EGH A;  1N2L A;  2W8D A;  1URA A;  2QZU A;  2W5Q A;  4FDI A;  1EJJ A;  4LR9 A;  3MK1 A;  2W8S A;  4NWJ A;  4KM4 A;  2D1G A;  5LQQ A;  1ED8 A;  1KHL A;  4ZG7 A;  2W5W A;  5LIA A;  1AJD A;  1HQA A;  4UPK A;  1KH4 A;  5DLT A;  4LR2 A;  3Q3Q A;  1KH5 A;  3NKM A;  4ZG6 A;  1AJA A;  3WAV A;  1ALI A;  3BDG B;  2W5R A;  1E2S P;  4LRE A;  4GTX A;  3A52 A;  2ANH A;  3TG0 A;  5C66 A;  1ED9 A;  4LRA A;  1KH9 A;  3E2D A;  2XRG A;  1O98 A;  4B56 A;  3UN5 A;  1SHN A;  4LRC A;  5TJ3 A;  3TWZ A;  2W5V A;  3M8Y A;  3SZY A;  3M8Z A;  3NKN A;  5L0E A;  3M7V A;  3IDD A;  4N7T A;  4NWX A;  1ALH A;  4LR8 A;  3TX0 A;  4MHX A;  2IUC B;  3BDG A;  1ANI A;  3ED4 A;  1P49 A;  1Y7A A;  4KAV A;  5GRR A;  1EW8 A;  3BDF A;  5K4P A;  4YR1 A;  1O99 A;  3T00 A;  5INH A;  3UNY A;  4TN0 A;  3LXQ A;  3KD8 A;  3WAW A;  3B5Q A;  5AJ9 A;  1EW2 A;  4UOO A;  1ELY A;  1ZEF A;  2VQR A;  2GLQ A;  3SZZ A;  5IJS A;  3IGZ B;  3BDH A;  1KHN A;  4KJD A;  5KXA A;  1HDH A;  5EGE A;  3WBH A;  4LQY A;  4KAY A;  3T02 A;  1HJK A; 
#chains in the Genus database with same CATH homology
 5DLW A;  5LRM A;  5L0B A;  4GTW A;  1ANJ A;  4UOR A;  3DPC A;  3M8W A;  4GTY A;  1ELZ A;  1KHJ A;  2IUC A;  3NVL A;  3NKO A;  1AJC A;  4CXK A;  3UN2 A;  1ZED A;  4QAX A;  2GSU A;  2XR9 A;  2X98 A;  2W5T A;  2GSN A;  1FSU A;  1ELX A;  3UN3 A;  5L0K A;  1Y6V A;  5IJQ A;  3T01 A;  3NKR A;  1AUK A;  4GTZ A;  2W5X A;  1ALJ A;  4CYR A;  4CYS A;  3DYC A;  1E1Z P;  1EI6 A;  4LR7 A;  4LRB A;  3WAY A;  2W5S A;  2IFY A;  4UPL A;  4MY4 A;  4FDJ A;  2GSO A;  5GOV A;  3MK0 A;  4LRF A;  1ALK A;  1EQJ A;  3OT9 A;  4ZGA A;  3NKQ A;  1KHK A;  3NKP A;  1URB A;  5HRT A;  1E33 P;  1AJB A;  3UO0 A;  1KH7 A;  4CXU A;  2RH6 A;  1B8J A;  3MK2 A;  3WAX A;  1K7H A;  4UPH A;  4KJG A;  4UPI A;  4ZG9 A;  1E3C P;  2ZKT A;  4CXS A;  3CMR A;  5DLV A;  1N2K A;  5LRN A;  1SHQ A;  2G9Y A;  4UOP A;  1ZEB A;  4MIV A;  1EW9 A;  2GA3 A;  3IGY B;  4LRD A;  5EGH A;  1N2L A;  2W8D A;  1URA A;  2QZU A;  2W5Q A;  4FDI A;  1EJJ A;  4LR9 A;  3MK1 A;  2W8S A;  4NWJ A;  4KM4 A;  2D1G A;  5LQQ A;  1ED8 A;  1KHL A;  4ZG7 A;  2W5W A;  5LIA A;  1AJD A;  1HQA A;  4UPK A;  1KH4 A;  5DLT A;  4LR2 A;  3Q3Q A;  1KH5 A;  3NKM A;  4ZG6 A;  1AJA A;  3WAV A;  1ALI A;  3BDG B;  2W5R A;  1E2S P;  4LRE A;  4GTX A;  3A52 A;  2ANH A;  3TG0 A;  5C66 A;  1ED9 A;  4LRA A;  1KH9 A;  3E2D A;  2XRG A;  1O98 A;  4B56 A;  3UN5 A;  1SHN A;  4LRC A;  5TJ3 A;  3TWZ A;  2W5V A;  3M8Y A;  3SZY A;  3M8Z A;  3NKN A;  5L0E A;  3M7V A;  3IDD A;  4N7T A;  4NWX A;  1ALH A;  4LR8 A;  3TX0 A;  4MHX A;  2IUC B;  3BDG A;  1ANI A;  3ED4 A;  1P49 A;  1Y7A A;  4KAV A;  5GRR A;  1EW8 A;  3BDF A;  5K4P A;  4YR1 A;  1O99 A;  3T00 A;  5INH A;  3UNY A;  4TN0 A;  3LXQ A;  3KD8 A;  3WAW A;  3B5Q A;  5AJ9 A;  1EW2 A;  4UOO A;  1ELY A;  1ZEF A;  2VQR A;  2GLQ A;  3SZZ A;  5IJS A;  3IGZ B;  3BDH A;  1KHN A;  4KJD A;  5KXA A;  1HDH A;  5EGE A;  3WBH A;  4LQY A;  4KAY A;  3T02 A;  1HJK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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