1Y7AA

Structure of d153h/k328w e. coli alkaline phosphatase in presence of cobalt at 1.77 a resolution
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDWQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y7aA00
5GOVA 2W8DA 4KJDA 1KHKA 3UNYA 2W5QA 3NVLA 3SZZA 3TWZA 1O99A 2W5TA 1ELXA 4KAYA 4TN0A 1HDHA 3DPCA 4CYRA 4ZG9A 5LRMA 2IUCB 3M8WA 4LQYA 3MK2A 2W5RA 4N7TA 4GTWA 3M8ZA 2GLQA 3NKMA 1KH4A 4NWJA 1E2SP 2IFYA 3CMRA 3IGYB 1HJKA 1Y6VA 4UPKA 5DLWA 4QAXA 5LRNA 4ZG7A 2D1GA 3WAXA 2IUCA 3LXQA 1AUKA 3MK0A 5HRTA 2ANHA 4LRAA 3T02A 5L0EA 4LRCA 1ED9A 2G9YA 3IGZB 3B5QA 4GTZA 3NKPA 1SHQA 4YR1A 3BDFA 3T01A 1AJAA 3OT9A 1EW9A 4CXSA 3E2DA 1ZEDA 5KXAA 5INHA 1KH7A 2GSUA 4KAVA 4MHXA 3TX0A 4CXUA 5IJQA 4ZGAA 4B56A 4ZG6A 3A52A 1ALJA 1EQJA 2W5WA 2ZKTA 3WAVA 1N2LA 1KHJA 4UOOA 5DLVA 1ALHA 1FSUA 1EW8A 1KH9A 1URAA 1AJCA 3UN2A 3KD8A 1URBA 4GTXA 4KM4A 4LRFA 4NWXA 5GRRA 2W8SA 4LREA 5EGEA 5DLTA 3WBHA 1ALKA 2W5VA 1KHLA 1N2KA 3T00A 4LR7A 4UPIA 1Y7AA 4MY4A 1E3CP 5LQQA 1EW2A 5TJ3A 1SHNA 3WAYA 2XR9A 3UN3A 3UO0A 4LRDA 3DYCA 3BDHA 2X98A 2QZUA 1B8JA 5EGHA 3TG0A 5C66A 3NKQA 1KH5A 4UOPA 3WAWA 1KHNA 2W5XA 4CXKA 3ED4A 2GSNA 4CYSA 2RH6A 1ED8A 3NKOA 3UN5A 1EJJA 3Q3QA 2GSOA 2VQRA 2W5SA 4UPLA 3NKRA 3IDDA 1AJDA 5LIAA 4MIVA 1ANIA 5L0KA 4LRBA 1ELYA 2GA3A 2XRGA 3BDGB 3NKNA 4LR9A 3MK1A 1HQAA 1K7HA 5K4PA 3SZYA 1ZEFA 1O98A 4FDJA 1P49A 1ELZA 4UPHA 1ZEBA 5L0BA 3M8YA 3BDGA 4LR2A 1EI6A 4KJGA 5AJ9A 3M7VA 4FDIA 1ANJA 5IJSA 1AJBA 4LR8A 1ALIA 1E1ZP 4UORA 4GTYA 1E33P
chains in the Genus database with same CATH superfamily
5GOVA 2W8DA 4KJDA 1KHKA 3UNYA 2W5QA 3NVLA 3SZZA 3TWZA 1O99A 2W5TA 1ELXA 4KAYA 4TN0A 1HDHA 3DPCA 4CYRA 4ZG9A 5LRMA 2IUCB 3M8WA 4LQYA 3MK2A 2W5RA 4N7TA 4GTWA 3M8ZA 2GLQA 3NKMA 1KH4A 4NWJA 1E2SP 2IFYA 3CMRA 3IGYB 1HJKA 1Y6VA 4UPKA 5DLWA 4QAXA 5LRNA 4ZG7A 2D1GA 3WAXA 2IUCA 3LXQA 1AUKA 3MK0A 5HRTA 2ANHA 4LRAA 3T02A 5L0EA 4LRCA 1ED9A 2G9YA 3IGZB 3B5QA 4GTZA 3NKPA 1SHQA 4YR1A 3BDFA 3T01A 1AJAA 3OT9A 1EW9A 4CXSA 3E2DA 1ZEDA 5KXAA 5INHA 1KH7A 2GSUA 4KAVA 4MHXA 3TX0A 4CXUA 5IJQA 4ZGAA 4B56A 4ZG6A 3A52A 1ALJA 1EQJA 2W5WA 2ZKTA 3WAVA 1N2LA 1KHJA 4UOOA 5DLVA 1ALHA 1FSUA 1EW8A 1KH9A 1URAA 1AJCA 3UN2A 3KD8A 1URBA 4GTXA 4KM4A 4LRFA 4NWXA 5GRRA 2W8SA 4LREA 5EGEA 5DLTA 3WBHA 1ALKA 2W5VA 1KHLA 1N2KA 3T00A 4LR7A 4UPIA 1Y7AA 4MY4A 1E3CP 5LQQA 1EW2A 5TJ3A 1SHNA 3WAYA 2XR9A 3UN3A 3UO0A 4LRDA 3DYCA 3BDHA 2X98A 2QZUA 1B8JA 5EGHA 3TG0A 5C66A 3NKQA 1KH5A 4UOPA 3WAWA 1KHNA 2W5XA 4CXKA 3ED4A 2GSNA 4CYSA 2RH6A 1ED8A 3NKOA 3UN5A 1EJJA 3Q3QA 2GSOA 2VQRA 2W5SA 4UPLA 3NKRA 3IDDA 1AJDA 5LIAA 4MIVA 1ANIA 5L0KA 4LRBA 1ELYA 2GA3A 2XRGA 3BDGB 3NKNA 4LR9A 3MK1A 1HQAA 1K7HA 5K4PA 3SZYA 1ZEFA 1O98A 4FDJA 1P49A 1ELZA 4UPHA 1ZEBA 5L0BA 3M8YA 3BDGA 4LR2A 1EI6A 4KJGA 5AJ9A 3M7VA 4FDIA 1ANJA 5IJSA 1AJBA 4LR8A 1ALIA 1E1ZP 4UORA 4GTYA 1E33P
chains in the Genus database with same CATH topology
5GOVA 2W8DA 4KJDA 1KHKA 3UNYA 2W5QA 3NVLA 3SZZA 3TWZA 1O99A 2W5TA 1ELXA 4KAYA 4TN0A 1HDHA 3DPCA 4CYRA 4ZG9A 5LRMA 2IUCB 3M8WA 4LQYA 3MK2A 2W5RA 4N7TA 4GTWA 3M8ZA 2GLQA 3NKMA 1KH4A 4NWJA 1E2SP 2IFYA 3CMRA 3IGYB 1HJKA 1Y6VA 4UPKA 5DLWA 4QAXA 5LRNA 4ZG7A 2D1GA 3WAXA 2IUCA 3LXQA 1AUKA 3MK0A 5HRTA 2ANHA 4LRAA 3T02A 5L0EA 4LRCA 1ED9A 2G9YA 3IGZB 3B5QA 4GTZA 3NKPA 1SHQA 4YR1A 3BDFA 3T01A 1AJAA 3OT9A 1EW9A 4CXSA 3E2DA 1ZEDA 5KXAA 5INHA 1KH7A 2GSUA 4KAVA 4MHXA 3TX0A 4CXUA 5IJQA 4ZGAA 4B56A 4ZG6A 3A52A 1ALJA 1EQJA 2W5WA 2ZKTA 3WAVA 1N2LA 1KHJA 4UOOA 5DLVA 1ALHA 1FSUA 1EW8A 1KH9A 1URAA 1AJCA 3UN2A 3KD8A 1URBA 4GTXA 4KM4A 4LRFA 4NWXA 5GRRA 2W8SA 4LREA 5EGEA 5DLTA 3WBHA 1ALKA 2W5VA 1KHLA 1N2KA 3T00A 4LR7A 4UPIA 1Y7AA 4MY4A 1E3CP 5LQQA 1EW2A 5TJ3A 1SHNA 3WAYA 2XR9A 3UN3A 3UO0A 4LRDA 3DYCA 3BDHA 2X98A 2QZUA 1B8JA 5EGHA 3TG0A 5C66A 3NKQA 1KH5A 4UOPA 3WAWA 1KHNA 2W5XA 4CXKA 3ED4A 2GSNA 4CYSA 2RH6A 1ED8A 3NKOA 3UN5A 1EJJA 3Q3QA 2GSOA 2VQRA 2W5SA 4UPLA 3NKRA 3IDDA 1AJDA 5LIAA 4MIVA 1ANIA 5L0KA 4LRBA 1ELYA 2GA3A 2XRGA 3BDGB 3NKNA 4LR9A 3MK1A 1HQAA 1K7HA 5K4PA 3SZYA 1ZEFA 1O98A 4FDJA 1P49A 1ELZA 4UPHA 1ZEBA 5L0BA 3M8YA 3BDGA 4LR2A 1EI6A 4KJGA 5AJ9A 3M7VA 4FDIA 1ANJA 5IJSA 1AJBA 4LR8A 1ALIA 1E1ZP 4UORA 4GTYA 1E33P
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GOV A;  2W8D A;  4KJD A;  1KHK A;  3UNY A;  2W5Q A;  3NVL A;  3SZZ A;  3TWZ A;  1O99 A;  2W5T A;  1ELX A;  4KAY A;  4TN0 A;  1HDH A;  3DPC A;  4CYR A;  4ZG9 A;  5LRM A;  2IUC B;  3M8W A;  4LQY A;  3MK2 A;  2W5R A;  4N7T A;  4GTW A;  3M8Z A;  2GLQ A;  3NKM A;  1KH4 A;  4NWJ A;  1E2S P;  2IFY A;  3CMR A;  3IGY B;  1HJK A;  1Y6V A;  4UPK A;  5DLW A;  4QAX A;  5LRN A;  4ZG7 A;  2D1G A;  3WAX A;  2IUC A;  3LXQ A;  1AUK A;  3MK0 A;  5HRT A;  2ANH A;  4LRA A;  3T02 A;  5L0E A;  4LRC A;  1ED9 A;  2G9Y A;  3IGZ B;  3B5Q A;  4GTZ A;  3NKP A;  1SHQ A;  4YR1 A;  3BDF A;  3T01 A;  1AJA A;  3OT9 A;  1EW9 A;  4CXS A;  3E2D A;  1ZED A;  5KXA A;  5INH A;  1KH7 A;  2GSU A;  4KAV A;  4MHX A;  3TX0 A;  4CXU A;  5IJQ A;  4ZGA A;  4B56 A;  4ZG6 A;  3A52 A;  1ALJ A;  1EQJ A;  2W5W A;  2ZKT A;  3WAV A;  1N2L A;  1KHJ A;  4UOO A;  5DLV A;  1ALH A;  1FSU A;  1EW8 A;  1KH9 A;  1URA A;  1AJC A;  3UN2 A;  3KD8 A;  1URB A;  4GTX A;  4KM4 A;  4LRF A;  4NWX A;  5GRR A;  2W8S A;  4LRE A;  5EGE A;  5DLT A;  3WBH A;  1ALK A;  2W5V A;  1KHL A;  1N2K A;  3T00 A;  4LR7 A;  4UPI A;  1Y7A A;  4MY4 A;  1E3C P;  5LQQ A;  1EW2 A;  5TJ3 A;  1SHN A;  3WAY A;  2XR9 A;  3UN3 A;  3UO0 A;  4LRD A;  3DYC A;  3BDH A;  2X98 A;  2QZU A;  1B8J A;  5EGH A;  3TG0 A;  5C66 A;  3NKQ A;  1KH5 A;  4UOP A;  3WAW A;  1KHN A;  2W5X A;  4CXK A;  3ED4 A;  2GSN A;  4CYS A;  2RH6 A;  1ED8 A;  3NKO A;  3UN5 A;  1EJJ A;  3Q3Q A;  2GSO A;  2VQR A;  2W5S A;  4UPL A;  3NKR A;  3IDD A;  1AJD A;  5LIA A;  4MIV A;  1ANI A;  5L0K A;  4LRB A;  1ELY A;  2GA3 A;  2XRG A;  3BDG B;  3NKN A;  4LR9 A;  3MK1 A;  1HQA A;  1K7H A;  5K4P A;  3SZY A;  1ZEF A;  1O98 A;  4FDJ A;  1P49 A;  1ELZ A;  4UPH A;  1ZEB A;  5L0B A;  3M8Y A;  3BDG A;  4LR2 A;  1EI6 A;  4KJG A;  5AJ9 A;  3M7V A;  4FDI A;  1ANJ A;  5IJS A;  1AJB A;  4LR8 A;  1ALI A;  1E1Z P;  4UOR A;  4GTY A;  1E33 P; 
#chains in the Genus database with same CATH topology
 5GOV A;  2W8D A;  4KJD A;  1KHK A;  3UNY A;  2W5Q A;  3NVL A;  3SZZ A;  3TWZ A;  1O99 A;  2W5T A;  1ELX A;  4KAY A;  4TN0 A;  1HDH A;  3DPC A;  4CYR A;  4ZG9 A;  5LRM A;  2IUC B;  3M8W A;  4LQY A;  3MK2 A;  2W5R A;  4N7T A;  4GTW A;  3M8Z A;  2GLQ A;  3NKM A;  1KH4 A;  4NWJ A;  1E2S P;  2IFY A;  3CMR A;  3IGY B;  1HJK A;  1Y6V A;  4UPK A;  5DLW A;  4QAX A;  5LRN A;  4ZG7 A;  2D1G A;  3WAX A;  2IUC A;  3LXQ A;  1AUK A;  3MK0 A;  5HRT A;  2ANH A;  4LRA A;  3T02 A;  5L0E A;  4LRC A;  1ED9 A;  2G9Y A;  3IGZ B;  3B5Q A;  4GTZ A;  3NKP A;  1SHQ A;  4YR1 A;  3BDF A;  3T01 A;  1AJA A;  3OT9 A;  1EW9 A;  4CXS A;  3E2D A;  1ZED A;  5KXA A;  5INH A;  1KH7 A;  2GSU A;  4KAV A;  4MHX A;  3TX0 A;  4CXU A;  5IJQ A;  4ZGA A;  4B56 A;  4ZG6 A;  3A52 A;  1ALJ A;  1EQJ A;  2W5W A;  2ZKT A;  3WAV A;  1N2L A;  1KHJ A;  4UOO A;  5DLV A;  1ALH A;  1FSU A;  1EW8 A;  1KH9 A;  1URA A;  1AJC A;  3UN2 A;  3KD8 A;  1URB A;  4GTX A;  4KM4 A;  4LRF A;  4NWX A;  5GRR A;  2W8S A;  4LRE A;  5EGE A;  5DLT A;  3WBH A;  1ALK A;  2W5V A;  1KHL A;  1N2K A;  3T00 A;  4LR7 A;  4UPI A;  1Y7A A;  4MY4 A;  1E3C P;  5LQQ A;  1EW2 A;  5TJ3 A;  1SHN A;  3WAY A;  2XR9 A;  3UN3 A;  3UO0 A;  4LRD A;  3DYC A;  3BDH A;  2X98 A;  2QZU A;  1B8J A;  5EGH A;  3TG0 A;  5C66 A;  3NKQ A;  1KH5 A;  4UOP A;  3WAW A;  1KHN A;  2W5X A;  4CXK A;  3ED4 A;  2GSN A;  4CYS A;  2RH6 A;  1ED8 A;  3NKO A;  3UN5 A;  1EJJ A;  3Q3Q A;  2GSO A;  2VQR A;  2W5S A;  4UPL A;  3NKR A;  3IDD A;  1AJD A;  5LIA A;  4MIV A;  1ANI A;  5L0K A;  4LRB A;  1ELY A;  2GA3 A;  2XRG A;  3BDG B;  3NKN A;  4LR9 A;  3MK1 A;  1HQA A;  1K7H A;  5K4P A;  3SZY A;  1ZEF A;  1O98 A;  4FDJ A;  1P49 A;  1ELZ A;  4UPH A;  1ZEB A;  5L0B A;  3M8Y A;  3BDG A;  4LR2 A;  1EI6 A;  4KJG A;  5AJ9 A;  3M7V A;  4FDI A;  1ANJ A;  5IJS A;  1AJB A;  4LR8 A;  1ALI A;  1E1Z P;  4UOR A;  4GTY A;  1E33 P; 
#chains in the Genus database with same CATH homology
 5GOV A;  2W8D A;  4KJD A;  1KHK A;  3UNY A;  2W5Q A;  3NVL A;  3SZZ A;  3TWZ A;  1O99 A;  2W5T A;  1ELX A;  4KAY A;  4TN0 A;  1HDH A;  3DPC A;  4CYR A;  4ZG9 A;  5LRM A;  2IUC B;  3M8W A;  4LQY A;  3MK2 A;  2W5R A;  4N7T A;  4GTW A;  3M8Z A;  2GLQ A;  3NKM A;  1KH4 A;  4NWJ A;  1E2S P;  2IFY A;  3CMR A;  3IGY B;  1HJK A;  1Y6V A;  4UPK A;  5DLW A;  4QAX A;  5LRN A;  4ZG7 A;  2D1G A;  3WAX A;  2IUC A;  3LXQ A;  1AUK A;  3MK0 A;  5HRT A;  2ANH A;  4LRA A;  3T02 A;  5L0E A;  4LRC A;  1ED9 A;  2G9Y A;  3IGZ B;  3B5Q A;  4GTZ A;  3NKP A;  1SHQ A;  4YR1 A;  3BDF A;  3T01 A;  1AJA A;  3OT9 A;  1EW9 A;  4CXS A;  3E2D A;  1ZED A;  5KXA A;  5INH A;  1KH7 A;  2GSU A;  4KAV A;  4MHX A;  3TX0 A;  4CXU A;  5IJQ A;  4ZGA A;  4B56 A;  4ZG6 A;  3A52 A;  1ALJ A;  1EQJ A;  2W5W A;  2ZKT A;  3WAV A;  1N2L A;  1KHJ A;  4UOO A;  5DLV A;  1ALH A;  1FSU A;  1EW8 A;  1KH9 A;  1URA A;  1AJC A;  3UN2 A;  3KD8 A;  1URB A;  4GTX A;  4KM4 A;  4LRF A;  4NWX A;  5GRR A;  2W8S A;  4LRE A;  5EGE A;  5DLT A;  3WBH A;  1ALK A;  2W5V A;  1KHL A;  1N2K A;  3T00 A;  4LR7 A;  4UPI A;  1Y7A A;  4MY4 A;  1E3C P;  5LQQ A;  1EW2 A;  5TJ3 A;  1SHN A;  3WAY A;  2XR9 A;  3UN3 A;  3UO0 A;  4LRD A;  3DYC A;  3BDH A;  2X98 A;  2QZU A;  1B8J A;  5EGH A;  3TG0 A;  5C66 A;  3NKQ A;  1KH5 A;  4UOP A;  3WAW A;  1KHN A;  2W5X A;  4CXK A;  3ED4 A;  2GSN A;  4CYS A;  2RH6 A;  1ED8 A;  3NKO A;  3UN5 A;  1EJJ A;  3Q3Q A;  2GSO A;  2VQR A;  2W5S A;  4UPL A;  3NKR A;  3IDD A;  1AJD A;  5LIA A;  4MIV A;  1ANI A;  5L0K A;  4LRB A;  1ELY A;  2GA3 A;  2XRG A;  3BDG B;  3NKN A;  4LR9 A;  3MK1 A;  1HQA A;  1K7H A;  5K4P A;  3SZY A;  1ZEF A;  1O98 A;  4FDJ A;  1P49 A;  1ELZ A;  4UPH A;  1ZEB A;  5L0B A;  3M8Y A;  3BDG A;  4LR2 A;  1EI6 A;  4KJG A;  5AJ9 A;  3M7V A;  4FDI A;  1ANJ A;  5IJS A;  1AJB A;  4LR8 A;  1ALI A;  1E1Z P;  4UOR A;  4GTY A;  1E33 P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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