1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
1O98A 1AJDA 4LR9A 3ED4A 1AJBA 1E3CP 5GOVA 1AUKA 2W5VA 2QZUA 4N7TA 3MK2A 3NKNA 1E2SP 1O99A 3DPCA 4KJGA 1ZEDA 4CXKA 3IGYB 3WAVA 2W5RA 3UN2A 1ELXA 3TX0A 3NKOA 5INHA 1FSUA 1ANIA 1N2LA 4ZG6A 4YR1A 1KHJA 2IUCB 4MIVA 1ALJA 4GTZA 4MHXA 1EJJA 3BDHA 1Y7AA 3E2DA 2GSUA 1E1ZP 5EGHA 3CMRA 1KH4A 1ELYA 2X98A 3M7VA 3T01A 3WAWA 1EW8A 1AJCA 2W8SA 4CYSA 1ELZA 2GLQA 2IFYA 1ALHA 3NKMA 1ALKA 3NVLA 5LRMA 3SZZA 3WAXA 5L0EA 1ZEBA 4LR8A 1P49A 1URBA 4UOOA 2W5XA 3WBHA 5IJSA 4KAYA 2GA3A 3BDGB 1ANJA 2W5WA 2IUCA 4GTWA 4NWJA 1K7HA 4CYRA 1KHLA 2XRGA 4GTXA 3DYCA 2ANHA 1Y6VA 1KHKA 1URAA 3OT9A 1KH7A 4QAXA 5L0BA 4FDIA 3MK1A 4UPHA 4FDJA 3BDFA 1ED8A 3NKPA 3M8WA 1EW2A 2GSNA 3IDDA 5IJQA 1ALIA 1KH9A 5K4PA 4CXUA 3WAYA 5KXAA 2W8DA 5LIAA 1EQJA 4LR2A 4LQYA 3TWZA 3BDGA 1HQAA 3IGZB 4ZG9A 4UPIA 4KAVA 2D1GA 2W5QA 3NKRA 1ZEFA 5HRTA 1EI6A 1ED9A 4NWXA 5GRRA 2GSOA 3Q3QA 1E33P 5C66A 4LRAA 4MY4A 4GTYA 1SHQA 4ZGAA 1HJKA 4LRFA 3M8ZA 4LRCA 3M8YA 5DLVA 5TJ3A 3UN3A 1N2KA 4LREA 3T02A 3LXQA 5LQQA 3A52A 4CXSA 3NKQA 5AJ9A 5L0KA 4LR7A 2W5TA 4ZG7A 5DLWA 1AJAA 3MK0A 5LRNA 2VQRA 1KH5A 2RH6A 4UOPA 2ZKTA 4KM4A 3UNYA 3UN5A 2XR9A 1HDHA 5DLTA 4TN0A 4B56A 4UPLA 1KHNA 3B5QA 4UORA 4LRDA 1SHNA 2W5SA 3T00A 4UPKA 3TG0A 4KJDA 4LRBA 3KD8A 1EW9A 3UO0A 1B8JA 3SZYA 5EGEA 2G9YA
chains in the Genus database with same CATH superfamily
1O98A 1AJDA 4LR9A 3ED4A 1AJBA 1E3CP 5GOVA 1AUKA 2W5VA 2QZUA 4N7TA 3MK2A 3NKNA 1E2SP 1O99A 3DPCA 4KJGA 1ZEDA 4CXKA 3IGYB 3WAVA 2W5RA 3UN2A 1ELXA 3TX0A 3NKOA 5INHA 1FSUA 1ANIA 1N2LA 4ZG6A 4YR1A 1KHJA 2IUCB 4MIVA 1ALJA 4GTZA 4MHXA 1EJJA 3BDHA 1Y7AA 3E2DA 2GSUA 1E1ZP 5EGHA 3CMRA 1KH4A 1ELYA 2X98A 3M7VA 3T01A 3WAWA 1EW8A 1AJCA 2W8SA 4CYSA 1ELZA 2GLQA 2IFYA 1ALHA 3NKMA 1ALKA 3NVLA 5LRMA 3SZZA 3WAXA 5L0EA 1ZEBA 4LR8A 1P49A 1URBA 4UOOA 2W5XA 3WBHA 5IJSA 4KAYA 2GA3A 3BDGB 1ANJA 2W5WA 2IUCA 4GTWA 4NWJA 1K7HA 4CYRA 1KHLA 2XRGA 4GTXA 3DYCA 2ANHA 1Y6VA 1KHKA 1URAA 3OT9A 1KH7A 4QAXA 5L0BA 4FDIA 3MK1A 4UPHA 4FDJA 3BDFA 1ED8A 3NKPA 3M8WA 1EW2A 2GSNA 3IDDA 5IJQA 1ALIA 1KH9A 5K4PA 4CXUA 3WAYA 5KXAA 2W8DA 5LIAA 1EQJA 4LR2A 4LQYA 3TWZA 3BDGA 1HQAA 3IGZB 4ZG9A 4UPIA 4KAVA 2D1GA 2W5QA 3NKRA 1ZEFA 5HRTA 1EI6A 1ED9A 4NWXA 5GRRA 2GSOA 3Q3QA 1E33P 5C66A 4LRAA 4MY4A 4GTYA 1SHQA 4ZGAA 1HJKA 4LRFA 3M8ZA 4LRCA 3M8YA 5DLVA 5TJ3A 3UN3A 1N2KA 4LREA 3T02A 3LXQA 5LQQA 3A52A 4CXSA 3NKQA 5AJ9A 5L0KA 4LR7A 2W5TA 4ZG7A 5DLWA 1AJAA 3MK0A 5LRNA 2VQRA 1KH5A 2RH6A 4UOPA 2ZKTA 4KM4A 3UNYA 3UN5A 2XR9A 1HDHA 5DLTA 4TN0A 4B56A 4UPLA 1KHNA 3B5QA 4UORA 4LRDA 1SHNA 2W5SA 3T00A 4UPKA 3TG0A 4KJDA 4LRBA 3KD8A 1EW9A 3UO0A 1B8JA 3SZYA 5EGEA 2G9YA
chains in the Genus database with same CATH topology
1O98A 1AJDA 4LR9A 3ED4A 1AJBA 1E3CP 5GOVA 1AUKA 2W5VA 2QZUA 4N7TA 3MK2A 3NKNA 1E2SP 1O99A 3DPCA 4KJGA 1ZEDA 4CXKA 3IGYB 3WAVA 2W5RA 3UN2A 1ELXA 3TX0A 3NKOA 5INHA 1FSUA 1ANIA 1N2LA 4ZG6A 4YR1A 1KHJA 2IUCB 4MIVA 1ALJA 4GTZA 4MHXA 1EJJA 3BDHA 1Y7AA 3E2DA 2GSUA 1E1ZP 5EGHA 3CMRA 1KH4A 1ELYA 2X98A 3M7VA 3T01A 3WAWA 1EW8A 1AJCA 2W8SA 4CYSA 1ELZA 2GLQA 2IFYA 1ALHA 3NKMA 1ALKA 3NVLA 5LRMA 3SZZA 3WAXA 5L0EA 1ZEBA 4LR8A 1P49A 1URBA 4UOOA 2W5XA 3WBHA 5IJSA 4KAYA 2GA3A 3BDGB 1ANJA 2W5WA 2IUCA 4GTWA 4NWJA 1K7HA 4CYRA 1KHLA 2XRGA 4GTXA 3DYCA 2ANHA 1Y6VA 1KHKA 1URAA 3OT9A 1KH7A 4QAXA 5L0BA 4FDIA 3MK1A 4UPHA 4FDJA 3BDFA 1ED8A 3NKPA 3M8WA 1EW2A 2GSNA 3IDDA 5IJQA 1ALIA 1KH9A 5K4PA 4CXUA 3WAYA 5KXAA 2W8DA 5LIAA 1EQJA 4LR2A 4LQYA 3TWZA 3BDGA 1HQAA 3IGZB 4ZG9A 4UPIA 4KAVA 2D1GA 2W5QA 3NKRA 1ZEFA 5HRTA 1EI6A 1ED9A 4NWXA 5GRRA 2GSOA 3Q3QA 1E33P 5C66A 4LRAA 4MY4A 4GTYA 1SHQA 4ZGAA 1HJKA 4LRFA 3M8ZA 4LRCA 3M8YA 5DLVA 5TJ3A 3UN3A 1N2KA 4LREA 3T02A 3LXQA 5LQQA 3A52A 4CXSA 3NKQA 5AJ9A 5L0KA 4LR7A 2W5TA 4ZG7A 5DLWA 1AJAA 3MK0A 5LRNA 2VQRA 1KH5A 2RH6A 4UOPA 2ZKTA 4KM4A 3UNYA 3UN5A 2XR9A 1HDHA 5DLTA 4TN0A 4B56A 4UPLA 1KHNA 3B5QA 4UORA 4LRDA 1SHNA 2W5SA 3T00A 4UPKA 3TG0A 4KJDA 4LRBA 3KD8A 1EW9A 3UO0A 1B8JA 3SZYA 5EGEA 2G9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O98 A;  1AJD A;  4LR9 A;  3ED4 A;  1AJB A;  1E3C P;  5GOV A;  1AUK A;  2W5V A;  2QZU A;  4N7T A;  3MK2 A;  3NKN A;  1E2S P;  1O99 A;  3DPC A;  4KJG A;  1ZED A;  4CXK A;  3IGY B;  3WAV A;  2W5R A;  3UN2 A;  1ELX A;  3TX0 A;  3NKO A;  5INH A;  1FSU A;  1ANI A;  1N2L A;  4ZG6 A;  4YR1 A;  1KHJ A;  2IUC B;  4MIV A;  1ALJ A;  4GTZ A;  4MHX A;  1EJJ A;  3BDH A;  1Y7A A;  3E2D A;  2GSU A;  1E1Z P;  5EGH A;  3CMR A;  1KH4 A;  1ELY A;  2X98 A;  3M7V A;  3T01 A;  3WAW A;  1EW8 A;  1AJC A;  2W8S A;  4CYS A;  1ELZ A;  2GLQ A;  2IFY A;  1ALH A;  3NKM A;  1ALK A;  3NVL A;  5LRM A;  3SZZ A;  3WAX A;  5L0E A;  1ZEB A;  4LR8 A;  1P49 A;  1URB A;  4UOO A;  2W5X A;  3WBH A;  5IJS A;  4KAY A;  2GA3 A;  3BDG B;  1ANJ A;  2W5W A;  2IUC A;  4GTW A;  4NWJ A;  1K7H A;  4CYR A;  1KHL A;  2XRG A;  4GTX A;  3DYC A;  2ANH A;  1Y6V A;  1KHK A;  1URA A;  3OT9 A;  1KH7 A;  4QAX A;  5L0B A;  4FDI A;  3MK1 A;  4UPH A;  4FDJ A;  3BDF A;  1ED8 A;  3NKP A;  3M8W A;  1EW2 A;  2GSN A;  3IDD A;  5IJQ A;  1ALI A;  1KH9 A;  5K4P A;  4CXU A;  3WAY A;  5KXA A;  2W8D A;  5LIA A;  1EQJ A;  4LR2 A;  4LQY A;  3TWZ A;  3BDG A;  1HQA A;  3IGZ B;  4ZG9 A;  4UPI A;  4KAV A;  2D1G A;  2W5Q A;  3NKR A;  1ZEF A;  5HRT A;  1EI6 A;  1ED9 A;  4NWX A;  5GRR A;  2GSO A;  3Q3Q A;  1E33 P;  5C66 A;  4LRA A;  4MY4 A;  4GTY A;  1SHQ A;  4ZGA A;  1HJK A;  4LRF A;  3M8Z A;  4LRC A;  3M8Y A;  5DLV A;  5TJ3 A;  3UN3 A;  1N2K A;  4LRE A;  3T02 A;  3LXQ A;  5LQQ A;  3A52 A;  4CXS A;  3NKQ A;  5AJ9 A;  5L0K A;  4LR7 A;  2W5T A;  4ZG7 A;  5DLW A;  1AJA A;  3MK0 A;  5LRN A;  2VQR A;  1KH5 A;  2RH6 A;  4UOP A;  2ZKT A;  4KM4 A;  3UNY A;  3UN5 A;  2XR9 A;  1HDH A;  5DLT A;  4TN0 A;  4B56 A;  4UPL A;  1KHN A;  3B5Q A;  4UOR A;  4LRD A;  1SHN A;  2W5S A;  3T00 A;  4UPK A;  3TG0 A;  4KJD A;  4LRB A;  3KD8 A;  1EW9 A;  3UO0 A;  1B8J A;  3SZY A;  5EGE A;  2G9Y A; 
#chains in the Genus database with same CATH topology
 1O98 A;  1AJD A;  4LR9 A;  3ED4 A;  1AJB A;  1E3C P;  5GOV A;  1AUK A;  2W5V A;  2QZU A;  4N7T A;  3MK2 A;  3NKN A;  1E2S P;  1O99 A;  3DPC A;  4KJG A;  1ZED A;  4CXK A;  3IGY B;  3WAV A;  2W5R A;  3UN2 A;  1ELX A;  3TX0 A;  3NKO A;  5INH A;  1FSU A;  1ANI A;  1N2L A;  4ZG6 A;  4YR1 A;  1KHJ A;  2IUC B;  4MIV A;  1ALJ A;  4GTZ A;  4MHX A;  1EJJ A;  3BDH A;  1Y7A A;  3E2D A;  2GSU A;  1E1Z P;  5EGH A;  3CMR A;  1KH4 A;  1ELY A;  2X98 A;  3M7V A;  3T01 A;  3WAW A;  1EW8 A;  1AJC A;  2W8S A;  4CYS A;  1ELZ A;  2GLQ A;  2IFY A;  1ALH A;  3NKM A;  1ALK A;  3NVL A;  5LRM A;  3SZZ A;  3WAX A;  5L0E A;  1ZEB A;  4LR8 A;  1P49 A;  1URB A;  4UOO A;  2W5X A;  3WBH A;  5IJS A;  4KAY A;  2GA3 A;  3BDG B;  1ANJ A;  2W5W A;  2IUC A;  4GTW A;  4NWJ A;  1K7H A;  4CYR A;  1KHL A;  2XRG A;  4GTX A;  3DYC A;  2ANH A;  1Y6V A;  1KHK A;  1URA A;  3OT9 A;  1KH7 A;  4QAX A;  5L0B A;  4FDI A;  3MK1 A;  4UPH A;  4FDJ A;  3BDF A;  1ED8 A;  3NKP A;  3M8W A;  1EW2 A;  2GSN A;  3IDD A;  5IJQ A;  1ALI A;  1KH9 A;  5K4P A;  4CXU A;  3WAY A;  5KXA A;  2W8D A;  5LIA A;  1EQJ A;  4LR2 A;  4LQY A;  3TWZ A;  3BDG A;  1HQA A;  3IGZ B;  4ZG9 A;  4UPI A;  4KAV A;  2D1G A;  2W5Q A;  3NKR A;  1ZEF A;  5HRT A;  1EI6 A;  1ED9 A;  4NWX A;  5GRR A;  2GSO A;  3Q3Q A;  1E33 P;  5C66 A;  4LRA A;  4MY4 A;  4GTY A;  1SHQ A;  4ZGA A;  1HJK A;  4LRF A;  3M8Z A;  4LRC A;  3M8Y A;  5DLV A;  5TJ3 A;  3UN3 A;  1N2K A;  4LRE A;  3T02 A;  3LXQ A;  5LQQ A;  3A52 A;  4CXS A;  3NKQ A;  5AJ9 A;  5L0K A;  4LR7 A;  2W5T A;  4ZG7 A;  5DLW A;  1AJA A;  3MK0 A;  5LRN A;  2VQR A;  1KH5 A;  2RH6 A;  4UOP A;  2ZKT A;  4KM4 A;  3UNY A;  3UN5 A;  2XR9 A;  1HDH A;  5DLT A;  4TN0 A;  4B56 A;  4UPL A;  1KHN A;  3B5Q A;  4UOR A;  4LRD A;  1SHN A;  2W5S A;  3T00 A;  4UPK A;  3TG0 A;  4KJD A;  4LRB A;  3KD8 A;  1EW9 A;  3UO0 A;  1B8J A;  3SZY A;  5EGE A;  2G9Y A; 
#chains in the Genus database with same CATH homology
 1O98 A;  1AJD A;  4LR9 A;  3ED4 A;  1AJB A;  1E3C P;  5GOV A;  1AUK A;  2W5V A;  2QZU A;  4N7T A;  3MK2 A;  3NKN A;  1E2S P;  1O99 A;  3DPC A;  4KJG A;  1ZED A;  4CXK A;  3IGY B;  3WAV A;  2W5R A;  3UN2 A;  1ELX A;  3TX0 A;  3NKO A;  5INH A;  1FSU A;  1ANI A;  1N2L A;  4ZG6 A;  4YR1 A;  1KHJ A;  2IUC B;  4MIV A;  1ALJ A;  4GTZ A;  4MHX A;  1EJJ A;  3BDH A;  1Y7A A;  3E2D A;  2GSU A;  1E1Z P;  5EGH A;  3CMR A;  1KH4 A;  1ELY A;  2X98 A;  3M7V A;  3T01 A;  3WAW A;  1EW8 A;  1AJC A;  2W8S A;  4CYS A;  1ELZ A;  2GLQ A;  2IFY A;  1ALH A;  3NKM A;  1ALK A;  3NVL A;  5LRM A;  3SZZ A;  3WAX A;  5L0E A;  1ZEB A;  4LR8 A;  1P49 A;  1URB A;  4UOO A;  2W5X A;  3WBH A;  5IJS A;  4KAY A;  2GA3 A;  3BDG B;  1ANJ A;  2W5W A;  2IUC A;  4GTW A;  4NWJ A;  1K7H A;  4CYR A;  1KHL A;  2XRG A;  4GTX A;  3DYC A;  2ANH A;  1Y6V A;  1KHK A;  1URA A;  3OT9 A;  1KH7 A;  4QAX A;  5L0B A;  4FDI A;  3MK1 A;  4UPH A;  4FDJ A;  3BDF A;  1ED8 A;  3NKP A;  3M8W A;  1EW2 A;  2GSN A;  3IDD A;  5IJQ A;  1ALI A;  1KH9 A;  5K4P A;  4CXU A;  3WAY A;  5KXA A;  2W8D A;  5LIA A;  1EQJ A;  4LR2 A;  4LQY A;  3TWZ A;  3BDG A;  1HQA A;  3IGZ B;  4ZG9 A;  4UPI A;  4KAV A;  2D1G A;  2W5Q A;  3NKR A;  1ZEF A;  5HRT A;  1EI6 A;  1ED9 A;  4NWX A;  5GRR A;  2GSO A;  3Q3Q A;  1E33 P;  5C66 A;  4LRA A;  4MY4 A;  4GTY A;  1SHQ A;  4ZGA A;  1HJK A;  4LRF A;  3M8Z A;  4LRC A;  3M8Y A;  5DLV A;  5TJ3 A;  3UN3 A;  1N2K A;  4LRE A;  3T02 A;  3LXQ A;  5LQQ A;  3A52 A;  4CXS A;  3NKQ A;  5AJ9 A;  5L0K A;  4LR7 A;  2W5T A;  4ZG7 A;  5DLW A;  1AJA A;  3MK0 A;  5LRN A;  2VQR A;  1KH5 A;  2RH6 A;  4UOP A;  2ZKT A;  4KM4 A;  3UNY A;  3UN5 A;  2XR9 A;  1HDH A;  5DLT A;  4TN0 A;  4B56 A;  4UPL A;  1KHN A;  3B5Q A;  4UOR A;  4LRD A;  1SHN A;  2W5S A;  3T00 A;  4UPK A;  3TG0 A;  4KJD A;  4LRB A;  3KD8 A;  1EW9 A;  3UO0 A;  1B8J A;  3SZY A;  5EGE A;  2G9Y A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...