2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
source organism Thermus thermophilus
molecule keywords methyl transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
4YQTA 3BBEA 3IEFA 1UAKA 3IC6A 4E8BA 2EGVA 2QWVA 3NK6A 5CO4A 3GYQA 4YQGA 3KTYA 4J3CA 2I6DA 1O6DA 1OY5A 4YQNA 5GMBA 1J85A 4YQBA 4YQ3A 4YQ7A 1VHKA 3ILKA 4YVHA 4XBOA 1UALA 3ONPA 4YQ8A 1VH0A 4CNDA 4L69A 4YVKA 2Z0YA 5D9FA 4YPWA 3DCMX 4YPXA 4YPYA 4YQ0A 1GZ0A 3NK7A 4YVJA 4YQPA 4YQQA 3AI9X 2NWAA 4YQ4A 4MCDA 2O3AA 4H3YA 4YQAA 1UAMA 4YQ5A 4FAKA 2HA8A 4YQ9A 4YQ2A 3BBHA 3OIJA 4JALA 1Z85A 4X3LA 3O7BA 1K3RA 3KW2A 4YQIA 2CX8A 3BBDA 4RG1A 1VHYA 4YQDA 2QMMA 4PZKA 4KDZA 4IG6A 1UAJA 3E5YA 1MXIA 4CNFA 3OINA 2V3KA 4MCBA 1NS5A 1V2XA 1ZJRA 4YQKA 1NXZA 3OIIA 5GMCA 4X3MA 1X7OA 4YQLA 4YQ1A 4MCCA 3N4KA 1IPAA 4CNEA 4YQSA 4YPZA 1P9PA 3QUVA 4KGNA 1X7PA 4YQOA 4H3ZA 3KY7A 4JAKA 3L8UA 4YQJA 5FAIA 4YQRA 1V6ZA 3AXZA 4YVGA 2YY8A 5GM8A 3N4JA 3KNUA 4YVIA 1TO0A 4CNGA 4YQ6A 2V3JA 4YQCA 3AIAA 2EGWA
chains in the Genus database with same CATH superfamily
4V194 4H3SA 4YQTA 3BBEA 3IEFA 4JYZA 1EUQA 4WCES 4WFNS 4IO9S 1UAKA 3IC6A 4E8BA 2EGVA 1GTSA 2QWVA 1QRSA 3NK6A 5CO4A 3GYQA 4YQGA 3KTYA 1QRTA 1O0BA 4JWJA 4J3CA 2I6DA 1D6KA 1O6DA 1OY5A 2PICA 4YQNA 3PIPS 5GMBA 1EXDA 1J85A 4YQBA 1FEUA 4YQ7A 4YQ3A 1VHKA 3ILKA 4YVHA 3PIOS 5GADW 2ZJQS 1QRUA 4XBOA 2AE0X 1UALA 3ONPA 4YQ8A 3DLLS 1VH0A 4CNDA 4L69A 5DM7S 5JVGS 1B75A 2GAEA 2Z0YA 4YVKA 5D9FA 4YPWA 2ZJRS 1GTRA 4UY88 3DCMX 5JVHS 4YPXA 4YPYA 2RE8A 1DFUP 4YQ0A 1GZ0A 3NK7A 5BNZA 4JXXA 4YVJA 4YQPA 4YQQA 3AI9X 2NWAA 1QTQA 4YQ4A 4MCDA 2O3AA 4H3YA 4YQAA 1UAMA 4H4KA 4YQ5A 4FAKA 2HA8A 4YQ9A 4YQ2A 3BBHA 4FMWA 4U67S 3OIJA 4JALA 2HZ7A 1Z85A 1UDXA 5GAGW 1ZJWA 4X3LA 3O7BA 1K3RA 3KW2A 4YQIA 2CX8A 3CZBA 3BBDA 4RG1A 1VHYA 4YQDA 2QMMA 4WFBS 4PZKA 1O0CA 4KDZA 4IOCS 4IG6A 1UAJA 4JWFA 2RD2A 3E5YA 5IZNA 1MXIA 4P2BA 3W2VB 4CNFA 3OINA 2V3KA 4MCBA 1NS5A 2PNWA 3W2WB 1V2XA 3AIIA 1ZJRA 4WFAS 2ZJPS 4YQKA 1NXZA 3OIIA 5GMCA 4X3MA 2PJJA 4JWHA 1EUYA 1X7OA 4YQLA 3J7ZV 4YQ1A 4MCCA 4JXZA 3N4KA 1IPAA 4CNEA 5GAHW 4YQSA 4YPZA 1P9PA 3QUVA 5GAEW 2G6GA 1NYLA 4KGNA 1X7PA 4YQOA 5HL7S 4H3ZA 3X1LB 3KY7A 4JAKA 3L8UA 4YQJA 5FAIA 4YQRA 2PI8A 4JWGA 1V6ZA 2G5DA 4IOAS 5DM6S 3AXZA 4YVGA 2YY8A 5GM8A 3N4JA 3KNUA 4YVIA 4WF9S 1TO0A 4CNGA 4YQ6A 3CF5S 2V3JA 4YQCA 3AIAA 2EGWA
chains in the Genus database with same CATH topology
4YQTA 3BBEA 3IEFA 1UAKA 3IC6A 4E8BA 2EGVA 2QWVA 3NK6A 5CO4A 3GYQA 4YQGA 3KTYA 4JWJA 4J3CA 2I6DA 1O6DA 1OY5A 4YQNA 5GMBA 1J85A 4YQBA 4YQ3A 4YQ7A 1VHKA 3ILKA 4YVHA 4XBOA 1UALA 3ONPA 4YQ8A 1VH0A 4CNDA 4L69A 4YVKA 2Z0YA 5D9FA 4YPWA 3DCMX 4YPXA 4YPYA 4YQ0A 1GZ0A 3NK7A 4YVJA 4YQPA 4YQQA 3AI9X 2NWAA 4YQ4A 4MCDA 2O3AA 4H3YA 4YQAA 1UAMA 4YQ5A 4FAKA 2HA8A 4YQ9A 4YQ2A 3BBHA 4FMWA 3OIJA 4JALA 1Z85A 4X3LA 3O7BA 1K3RA 3KW2A 4YQIA 2CX8A 3BBDA 4RG1A 1VHYA 4YQDA 2QMMA 4PZKA 4KDZA 4IG6A 1UAJA 4JWFA 3E5YA 1MXIA 4CNFA 3OINA 2V3KA 4MCBA 1NS5A 1V2XA 1ZJRA 4YQKA 1NXZA 3OIIA 5GMCA 4X3MA 4JWHA 1X7OA 4YQLA 4YQ1A 4MCCA 3N4KA 1IPAA 4CNEA 4YQSA 4YPZA 1P9PA 3QUVA 4KGNA 1X7PA 4YQOA 4H3ZA 3KY7A 4JAKA 3L8UA 4YQJA 5FAIA 4YQRA 4JWGA 1V6ZA 3AXZA 4YVGA 2YY8A 5GM8A 3N4JA 3KNUA 4YVIA 1TO0A 4CNGA 4YQ6A 2V3JA 4YQCA 3AIAA 2EGWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YQT A;  3BBE A;  3IEF A;  1UAK A;  3IC6 A;  4E8B A;  2EGV A;  2QWV A;  3NK6 A;  5CO4 A;  3GYQ A;  4YQG A;  3KTY A;  4J3C A;  2I6D A;  1O6D A;  1OY5 A;  4YQN A;  5GMB A;  1J85 A;  4YQB A;  4YQ3 A;  4YQ7 A;  1VHK A;  3ILK A;  4YVH A;  4XBO A;  1UAL A;  3ONP A;  4YQ8 A;  1VH0 A;  4CND A;  4L69 A;  4YVK A;  2Z0Y A;  5D9F A;  4YPW A;  3DCM X;  4YPX A;  4YPY A;  4YQ0 A;  1GZ0 A;  3NK7 A;  4YVJ A;  4YQP A;  4YQQ A;  3AI9 X;  2NWA A;  4YQ4 A;  4MCD A;  2O3A A;  4H3Y A;  4YQA A;  1UAM A;  4YQ5 A;  4FAK A;  2HA8 A;  4YQ9 A;  4YQ2 A;  3BBH A;  3OIJ A;  4JAL A;  1Z85 A;  4X3L A;  3O7B A;  1K3R A;  3KW2 A;  4YQI A;  2CX8 A;  3BBD A;  4RG1 A;  1VHY A;  4YQD A;  2QMM A;  4PZK A;  4KDZ A;  4IG6 A;  1UAJ A;  3E5Y A;  1MXI A;  4CNF A;  3OIN A;  2V3K A;  4MCB A;  1NS5 A;  1V2X A;  1ZJR A;  4YQK A;  1NXZ A;  3OII A;  5GMC A;  4X3M A;  1X7O A;  4YQL A;  4YQ1 A;  4MCC A;  3N4K A;  1IPA A;  4CNE A;  4YQS A;  4YPZ A;  1P9P A;  3QUV A;  4KGN A;  1X7P A;  4YQO A;  4H3Z A;  3KY7 A;  4JAK A;  3L8U A;  4YQJ A;  5FAI A;  4YQR A;  1V6Z A;  3AXZ A;  4YVG A;  2YY8 A;  5GM8 A;  3N4J A;  3KNU A;  4YVI A;  1TO0 A;  4CNG A;  4YQ6 A;  2V3J A;  4YQC A;  3AIA A;  2EGW A; 
#chains in the Genus database with same CATH topology
 4V19 4;  4H3S A;  4YQT A;  3BBE A;  3IEF A;  4JYZ A;  1EUQ A;  4WCE S;  4WFN S;  4IO9 S;  1UAK A;  3IC6 A;  4E8B A;  2EGV A;  1GTS A;  2QWV A;  1QRS A;  3NK6 A;  5CO4 A;  3GYQ A;  4YQG A;  3KTY A;  1QRT A;  1O0B A;  4JWJ A;  4J3C A;  2I6D A;  1D6K A;  1O6D A;  1OY5 A;  2PIC A;  4YQN A;  3PIP S;  5GMB A;  1EXD A;  1J85 A;  4YQB A;  1FEU A;  4YQ7 A;  4YQ3 A;  1VHK A;  3ILK A;  4YVH A;  3PIO S;  5GAD W;  2ZJQ S;  1QRU A;  4XBO A;  2AE0 X;  1UAL A;  3ONP A;  4YQ8 A;  3DLL S;  1VH0 A;  4CND A;  4L69 A;  5DM7 S;  5JVG S;  1B75 A;  2GAE A;  2Z0Y A;  4YVK A;  5D9F A;  4YPW A;  2ZJR S;  1GTR A;  4UY8 8;  3DCM X;  5JVH S;  4YPX A;  4YPY A;  2RE8 A;  1DFU P;  4YQ0 A;  1GZ0 A;  3NK7 A;  5BNZ A;  4JXX A;  4YVJ A;  4YQP A;  4YQQ A;  3AI9 X;  2NWA A;  1QTQ A;  4YQ4 A;  4MCD A;  2O3A A;  4H3Y A;  4YQA A;  1UAM A;  4H4K A;  4YQ5 A;  4FAK A;  2HA8 A;  4YQ9 A;  4YQ2 A;  3BBH A;  4FMW A;  4U67 S;  3OIJ A;  4JAL A;  2HZ7 A;  1Z85 A;  1UDX A;  5GAG W;  1ZJW A;  4X3L A;  3O7B A;  1K3R A;  3KW2 A;  4YQI A;  2CX8 A;  3CZB A;  3BBD A;  4RG1 A;  1VHY A;  4YQD A;  2QMM A;  4WFB S;  4PZK A;  1O0C A;  4KDZ A;  4IOC S;  4IG6 A;  1UAJ A;  4JWF A;  2RD2 A;  3E5Y A;  5IZN A;  1MXI A;  4P2B A;  3W2V B;  4CNF A;  3OIN A;  2V3K A;  4MCB A;  1NS5 A;  2PNW A;  3W2W B;  1V2X A;  3AII A;  1ZJR A;  4WFA S;  2ZJP S;  4YQK A;  1NXZ A;  3OII A;  5GMC A;  4X3M A;  2PJJ A;  4JWH A;  1EUY A;  1X7O A;  4YQL A;  3J7Z V;  4YQ1 A;  4MCC A;  4JXZ A;  3N4K A;  1IPA A;  4CNE A;  5GAH W;  4YQS A;  4YPZ A;  1P9P A;  3QUV A;  5GAE W;  2G6G A;  1NYL A;  4KGN A;  1X7P A;  4YQO A;  5HL7 S;  4H3Z A;  3X1L B;  3KY7 A;  4JAK A;  3L8U A;  4YQJ A;  5FAI A;  4YQR A;  2PI8 A;  4JWG A;  1V6Z A;  2G5D A;  4IOA S;  5DM6 S;  3AXZ A;  4YVG A;  2YY8 A;  5GM8 A;  3N4J A;  3KNU A;  4YVI A;  4WF9 S;  1TO0 A;  4CNG A;  4YQ6 A;  3CF5 S;  2V3J A;  4YQC A;  3AIA A;  2EGW A; 
#chains in the Genus database with same CATH homology
 4YQT A;  3BBE A;  3IEF A;  1UAK A;  3IC6 A;  4E8B A;  2EGV A;  2QWV A;  3NK6 A;  5CO4 A;  3GYQ A;  4YQG A;  3KTY A;  4JWJ A;  4J3C A;  2I6D A;  1O6D A;  1OY5 A;  4YQN A;  5GMB A;  1J85 A;  4YQB A;  4YQ3 A;  4YQ7 A;  1VHK A;  3ILK A;  4YVH A;  4XBO A;  1UAL A;  3ONP A;  4YQ8 A;  1VH0 A;  4CND A;  4L69 A;  4YVK A;  2Z0Y A;  5D9F A;  4YPW A;  3DCM X;  4YPX A;  4YPY A;  4YQ0 A;  1GZ0 A;  3NK7 A;  4YVJ A;  4YQP A;  4YQQ A;  3AI9 X;  2NWA A;  4YQ4 A;  4MCD A;  2O3A A;  4H3Y A;  4YQA A;  1UAM A;  4YQ5 A;  4FAK A;  2HA8 A;  4YQ9 A;  4YQ2 A;  3BBH A;  4FMW A;  3OIJ A;  4JAL A;  1Z85 A;  4X3L A;  3O7B A;  1K3R A;  3KW2 A;  4YQI A;  2CX8 A;  3BBD A;  4RG1 A;  1VHY A;  4YQD A;  2QMM A;  4PZK A;  4KDZ A;  4IG6 A;  1UAJ A;  4JWF A;  3E5Y A;  1MXI A;  4CNF A;  3OIN A;  2V3K A;  4MCB A;  1NS5 A;  1V2X A;  1ZJR A;  4YQK A;  1NXZ A;  3OII A;  5GMC A;  4X3M A;  4JWH A;  1X7O A;  4YQL A;  4YQ1 A;  4MCC A;  3N4K A;  1IPA A;  4CNE A;  4YQS A;  4YPZ A;  1P9P A;  3QUV A;  4KGN A;  1X7P A;  4YQO A;  4H3Z A;  3KY7 A;  4JAK A;  3L8U A;  4YQJ A;  5FAI A;  4YQR A;  4JWG A;  1V6Z A;  3AXZ A;  4YVG A;  2YY8 A;  5GM8 A;  3N4J A;  3KNU A;  4YVI A;  1TO0 A;  4CNG A;  4YQ6 A;  2V3J A;  4YQC A;  3AIA A;  2EGW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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