2CX8A

Crystal structure of methyltransferase with ligand(sah)
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
Knots found
sequence length
225
structure length
225
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
source organism Thermus thermophilus
molecule keywords methyl transferase
total genus 70
structure length 225
sequence length 225
chains with identical sequence B
other databases KnotProt 2.0: K +31
ec nomenclature
pdb deposition date 2005-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
4YPZA 4E8BA 2HA8A 3N4JA 4XBOA 3OINA 4MCDA 2I6DA 3NK6A 3OIIA 2O3AA 4YPYA 1VHYA 1VHKA 4YQRA 4H3YA 4CNGA 3DCMX 4JALA 1UAJA 3KW2A 4YQOA 4KGNA 3QUVA 5FAIA 4YQ9A 1NS5A 4YVJA 3BBHA 4YQCA 5GMCA 2EGWA 3NK7A 4YQ5A 3ILKA 4L69A 4PZKA 3AIAA 1X7PA 2V3JA 4YQIA 3KY7A 2QWVA 4MCCA 3BBEA 1TO0A 4FAKA 3IEFA 1V2XA 4YVIA 4YQGA 2CX8A 4YQDA 2Z0YA 2QMMA 4YPWA 1K3RA 1IPAA 2YY8A 4CNEA 3KNUA 4YQJA 4CNFA 5GMBA 1J85A 4YQPA 3AXZA 4J3CA 4MCBA 1V6ZA 4YQ1A 1VH0A 1UAMA 3KTYA 3BBDA 3IC6A 1MXIA 4YQSA 4KDZA 3O7BA 1GZ0A 1O6DA 1X7OA 5CO4A 3GYQA 4YQ6A 4IG6A 4YQAA 4YPXA 4YQLA 5GM8A 3ONPA 4CNDA 2V3KA 1UAKA 4YQTA 3OIJA 4YQBA 4YQ0A 4YQKA 1UALA 4YVHA 2EGVA 3N4KA 4YQ4A 3AI9X 5D9FA 4X3LA 1Z85A 1P9PA 3L8UA 4YQ2A 3E5YA 4YQ8A 4YVGA 4YVKA 4H3ZA 4X3MA 2NWAA 4YQQA 1NXZA 1OY5A 1ZJRA 4YQ3A 4YQ7A 4YQNA 4JAKA 4RG1A
chains in the Genus database with same CATH superfamily
4YPZA 4E8BA 2HA8A 3N4JA 4XBOA 3OINA 4MCDA 5GAGW 3W2WB 4JYZA 4U67S 1UDXA 2I6DA 3NK6A 3OIIA 2PI8A 2O3AA 4YPYA 2PICA 1VHYA 4IOCS 4JWHA 1VHKA 5JVHS 4YQRA 1EXDA 4JXXA 4H3YA 1ZJWA 4CNGA 3DCMX 4JALA 1UAJA 2RD2A 3KW2A 1QRSA 2GAEA 4YQOA 4KGNA 3QUVA 5FAIA 2HZ7A 4YQ9A 1NS5A 4YVJA 3BBHA 3CF5S 4YQCA 4P2BA 1EUQA 5GMCA 2EGWA 3NK7A 4YQ5A 3ILKA 1EUYA 4L69A 4PZKA 3AIAA 1X7PA 2V3JA 4YQIA 3KY7A 1NYLA 2QWVA 1FEUA 4WFAS 4MCCA 3BBEA 1TO0A 3J7ZV 4FAKA 3IEFA 1V2XA 4JWFA 4YVIA 1B75A 4YQGA 2CX8A 1QRTA 4IOAS 2PJJA 5IZNA 4YQDA 2Z0YA 4H3SA 2QMMA 2PNWA 1K3RA 4YPWA 4JXZA 5JVGS 1IPAA 2YY8A 4CNEA 3KNUA 4YQJA 4CNFA 5GMBA 1J85A 2RE8A 3X1LB 4YQPA 3AXZA 4JWJA 4J3CA 5GAEW 1O0BA 1V6ZA 5BNZA 1VH0A 4MCBA 4YQ1A 1UAMA 3KTYA 3W2VB 1DFUP 3BBDA 1MXIA 3IC6A 4KDZA 4YQSA 4V194 2AE0X 2G6GA 3O7BA 5DM7S 1GZ0A 1O6DA 1X7OA 4H4KA 2ZJRS 5CO4A 3GYQA 1GTRA 4YQ6A 3CZBA 4IG6A 4WCES 4UY88 4YQAA 1QRUA 4YPXA 4WFBS 4YQLA 5GM8A 3ONPA 4CNDA 2V3KA 1D6KA 1UAKA 4YQTA 4WF9S 1GTSA 3OIJA 4YQBA 1QTQA 4YQ0A 4YQKA 5GADW 1UALA 4YVHA 4JWGA 2EGVA 3N4KA 4YQ4A 2ZJQS 5DM6S 3AIIA 3AI9X 5D9FA 4X3LA 1Z85A 1P9PA 3L8UA 4YQ2A 3PIPS 3E5YA 4YQ8A 3DLLS 5HL7S 4YVGA 1O0CA 4IO9S 4YVKA 4H3ZA 4X3MA 2G5DA 2ZJPS 2NWAA 5GAHW 1NXZA 1OY5A 1ZJRA 4YQQA 4YQ3A 4FMWA 4WFNS 4YQ7A 4YQNA 3PIOS 4JAKA 4RG1A
chains in the Genus database with same CATH topology
4YPZA 4E8BA 2HA8A 3N4JA 4XBOA 3OINA 4MCDA 2I6DA 3NK6A 3OIIA 2O3AA 4YPYA 1VHYA 4JWHA 1VHKA 4YQRA 4H3YA 4CNGA 3DCMX 4JALA 1UAJA 3KW2A 4YQOA 4KGNA 3QUVA 5FAIA 4YQ9A 1NS5A 4YVJA 3BBHA 4YQCA 5GMCA 2EGWA 3NK7A 4YQ5A 3ILKA 4L69A 4PZKA 3AIAA 1X7PA 2V3JA 4YQIA 3KY7A 2QWVA 4MCCA 3BBEA 1TO0A 4FAKA 3IEFA 1V2XA 4JWFA 4YVIA 4YQGA 2CX8A 4YQDA 2Z0YA 2QMMA 4YPWA 1K3RA 1IPAA 2YY8A 4CNEA 3KNUA 4YQJA 4CNFA 5GMBA 1J85A 4YQPA 3AXZA 4JWJA 4J3CA 4MCBA 1V6ZA 4YQ1A 1VH0A 1UAMA 3KTYA 3BBDA 3IC6A 1MXIA 4YQSA 4KDZA 3O7BA 1GZ0A 1O6DA 1X7OA 5CO4A 3GYQA 4YQ6A 4IG6A 4YQAA 4YPXA 4YQLA 5GM8A 3ONPA 4CNDA 2V3KA 1UAKA 4YQTA 3OIJA 4YQBA 4YQ0A 4YQKA 1UALA 4YVHA 4JWGA 2EGVA 3N4KA 4YQ4A 3AI9X 5D9FA 4X3LA 1Z85A 1P9PA 3L8UA 4YQ2A 3E5YA 4YQ8A 4YVGA 4YVKA 4H3ZA 4X3MA 2NWAA 4YQQA 1NXZA 1OY5A 1ZJRA 4YQ3A 4FMWA 4YQ7A 4YQNA 4JAKA 4RG1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YPZ A;  4E8B A;  2HA8 A;  3N4J A;  4XBO A;  3OIN A;  4MCD A;  2I6D A;  3NK6 A;  3OII A;  2O3A A;  4YPY A;  1VHY A;  1VHK A;  4YQR A;  4H3Y A;  4CNG A;  3DCM X;  4JAL A;  1UAJ A;  3KW2 A;  4YQO A;  4KGN A;  3QUV A;  5FAI A;  4YQ9 A;  1NS5 A;  4YVJ A;  3BBH A;  4YQC A;  5GMC A;  2EGW A;  3NK7 A;  4YQ5 A;  3ILK A;  4L69 A;  4PZK A;  3AIA A;  1X7P A;  2V3J A;  4YQI A;  3KY7 A;  2QWV A;  4MCC A;  3BBE A;  1TO0 A;  4FAK A;  3IEF A;  1V2X A;  4YVI A;  4YQG A;  2CX8 A;  4YQD A;  2Z0Y A;  2QMM A;  4YPW A;  1K3R A;  1IPA A;  2YY8 A;  4CNE A;  3KNU A;  4YQJ A;  4CNF A;  5GMB A;  1J85 A;  4YQP A;  3AXZ A;  4J3C A;  4MCB A;  1V6Z A;  4YQ1 A;  1VH0 A;  1UAM A;  3KTY A;  3BBD A;  3IC6 A;  1MXI A;  4YQS A;  4KDZ A;  3O7B A;  1GZ0 A;  1O6D A;  1X7O A;  5CO4 A;  3GYQ A;  4YQ6 A;  4IG6 A;  4YQA A;  4YPX A;  4YQL A;  5GM8 A;  3ONP A;  4CND A;  2V3K A;  1UAK A;  4YQT A;  3OIJ A;  4YQB A;  4YQ0 A;  4YQK A;  1UAL A;  4YVH A;  2EGV A;  3N4K A;  4YQ4 A;  3AI9 X;  5D9F A;  4X3L A;  1Z85 A;  1P9P A;  3L8U A;  4YQ2 A;  3E5Y A;  4YQ8 A;  4YVG A;  4YVK A;  4H3Z A;  4X3M A;  2NWA A;  4YQQ A;  1NXZ A;  1OY5 A;  1ZJR A;  4YQ3 A;  4YQ7 A;  4YQN A;  4JAK A;  4RG1 A; 
#chains in the Genus database with same CATH topology
 4YPZ A;  4E8B A;  2HA8 A;  3N4J A;  4XBO A;  3OIN A;  4MCD A;  5GAG W;  3W2W B;  4JYZ A;  4U67 S;  1UDX A;  2I6D A;  3NK6 A;  3OII A;  2PI8 A;  2O3A A;  4YPY A;  2PIC A;  1VHY A;  4IOC S;  4JWH A;  1VHK A;  5JVH S;  4YQR A;  1EXD A;  4JXX A;  4H3Y A;  1ZJW A;  4CNG A;  3DCM X;  4JAL A;  1UAJ A;  2RD2 A;  3KW2 A;  1QRS A;  2GAE A;  4YQO A;  4KGN A;  3QUV A;  5FAI A;  2HZ7 A;  4YQ9 A;  1NS5 A;  4YVJ A;  3BBH A;  3CF5 S;  4YQC A;  4P2B A;  1EUQ A;  5GMC A;  2EGW A;  3NK7 A;  4YQ5 A;  3ILK A;  1EUY A;  4L69 A;  4PZK A;  3AIA A;  1X7P A;  2V3J A;  4YQI A;  3KY7 A;  1NYL A;  2QWV A;  1FEU A;  4WFA S;  4MCC A;  3BBE A;  1TO0 A;  3J7Z V;  4FAK A;  3IEF A;  1V2X A;  4JWF A;  4YVI A;  1B75 A;  4YQG A;  2CX8 A;  1QRT A;  4IOA S;  2PJJ A;  5IZN A;  4YQD A;  2Z0Y A;  4H3S A;  2QMM A;  2PNW A;  1K3R A;  4YPW A;  4JXZ A;  5JVG S;  1IPA A;  2YY8 A;  4CNE A;  3KNU A;  4YQJ A;  4CNF A;  5GMB A;  1J85 A;  2RE8 A;  3X1L B;  4YQP A;  3AXZ A;  4JWJ A;  4J3C A;  5GAE W;  1O0B A;  1V6Z A;  5BNZ A;  1VH0 A;  4MCB A;  4YQ1 A;  1UAM A;  3KTY A;  3W2V B;  1DFU P;  3BBD A;  1MXI A;  3IC6 A;  4KDZ A;  4YQS A;  4V19 4;  2AE0 X;  2G6G A;  3O7B A;  5DM7 S;  1GZ0 A;  1O6D A;  1X7O A;  4H4K A;  2ZJR S;  5CO4 A;  3GYQ A;  1GTR A;  4YQ6 A;  3CZB A;  4IG6 A;  4WCE S;  4UY8 8;  4YQA A;  1QRU A;  4YPX A;  4WFB S;  4YQL A;  5GM8 A;  3ONP A;  4CND A;  2V3K A;  1D6K A;  1UAK A;  4YQT A;  4WF9 S;  1GTS A;  3OIJ A;  4YQB A;  1QTQ A;  4YQ0 A;  4YQK A;  5GAD W;  1UAL A;  4YVH A;  4JWG A;  2EGV A;  3N4K A;  4YQ4 A;  2ZJQ S;  5DM6 S;  3AII A;  3AI9 X;  5D9F A;  4X3L A;  1Z85 A;  1P9P A;  3L8U A;  4YQ2 A;  3PIP S;  3E5Y A;  4YQ8 A;  3DLL S;  5HL7 S;  4YVG A;  1O0C A;  4IO9 S;  4YVK A;  4H3Z A;  4X3M A;  2G5D A;  2ZJP S;  2NWA A;  5GAH W;  1NXZ A;  1OY5 A;  1ZJR A;  4YQQ A;  4YQ3 A;  4FMW A;  4WFN S;  4YQ7 A;  4YQN A;  3PIO S;  4JAK A;  4RG1 A; 
#chains in the Genus database with same CATH homology
 4YPZ A;  4E8B A;  2HA8 A;  3N4J A;  4XBO A;  3OIN A;  4MCD A;  2I6D A;  3NK6 A;  3OII A;  2O3A A;  4YPY A;  1VHY A;  4JWH A;  1VHK A;  4YQR A;  4H3Y A;  4CNG A;  3DCM X;  4JAL A;  1UAJ A;  3KW2 A;  4YQO A;  4KGN A;  3QUV A;  5FAI A;  4YQ9 A;  1NS5 A;  4YVJ A;  3BBH A;  4YQC A;  5GMC A;  2EGW A;  3NK7 A;  4YQ5 A;  3ILK A;  4L69 A;  4PZK A;  3AIA A;  1X7P A;  2V3J A;  4YQI A;  3KY7 A;  2QWV A;  4MCC A;  3BBE A;  1TO0 A;  4FAK A;  3IEF A;  1V2X A;  4JWF A;  4YVI A;  4YQG A;  2CX8 A;  4YQD A;  2Z0Y A;  2QMM A;  4YPW A;  1K3R A;  1IPA A;  2YY8 A;  4CNE A;  3KNU A;  4YQJ A;  4CNF A;  5GMB A;  1J85 A;  4YQP A;  3AXZ A;  4JWJ A;  4J3C A;  4MCB A;  1V6Z A;  4YQ1 A;  1VH0 A;  1UAM A;  3KTY A;  3BBD A;  3IC6 A;  1MXI A;  4YQS A;  4KDZ A;  3O7B A;  1GZ0 A;  1O6D A;  1X7O A;  5CO4 A;  3GYQ A;  4YQ6 A;  4IG6 A;  4YQA A;  4YPX A;  4YQL A;  5GM8 A;  3ONP A;  4CND A;  2V3K A;  1UAK A;  4YQT A;  3OIJ A;  4YQB A;  4YQ0 A;  4YQK A;  1UAL A;  4YVH A;  4JWG A;  2EGV A;  3N4K A;  4YQ4 A;  3AI9 X;  5D9F A;  4X3L A;  1Z85 A;  1P9P A;  3L8U A;  4YQ2 A;  3E5Y A;  4YQ8 A;  4YVG A;  4YVK A;  4H3Z A;  4X3M A;  2NWA A;  4YQQ A;  1NXZ A;  1OY5 A;  1ZJR A;  4YQ3 A;  4FMW A;  4YQ7 A;  4YQN A;  4JAK A;  4RG1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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