2W5XA

Structure of tab5 alkaline phosphatase mutant his 135 glu with mg bound in the m3 site.
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITEATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule tags Hydrolase
source organism Antarctic bacterium tab5
molecule keywords ALKALINE PHOSPHATASE
total genus 131
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5xA00
3NKRA 3OT9A 4UOPA 3TX0A 2GA3A 2W5WA 1KH5A 4UPKA 5GOVA 1KH7A 5DLVA 1AJCA 1KH9A 4LRFA 5LRMA 3T01A 3T02A 4CXUA 2W5VA 5LRNA 4LR8A 3MK0A 2W5RA 4NWJA 4ZG6A 3WAVA 1O98A 1KHJA 1AUKA 3NKNA 4NWXA 1ANJA 3E2DA 3IGYB 5LQQA 3M7VA 3IGZB 3T00A 2W5TA 4LQYA 3UN2A 1HDHA 5EGHA 3LXQA 3UN5A 1Y6VA 1ED9A 1SHQA 3M8YA 4UPLA 1EI6A 3SZZA 1ALIA 1HJKA 1EJJA 5KXAA 4MIVA 1URAA 3NVLA 2W8SA 3MK1A 5INHA 1HQAA 4UPHA 3UO0A 4KM4A 2W5QA 1P49A 4GTYA 2ZKTA 4N7TA 3NKQA 1ALKA 3BDGA 2VQRA 3TWZA 4CYRA 1AJBA 4MY4A 2QZUA 3WBHA 1B8JA 3UN3A 1N2KA 1KHKA 3NKMA 1E3CP 3MK2A 1KH4A 3B5QA 4QAXA 4FDIA 4KAVA 5HRTA 2RH6A 3KD8A 4ZGAA 1ZEBA 2IUCB 4KJDA 4MHXA 1ELXA 1SHNA 4FDJA 2X98A 2GSUA 2W5XA 2GSOA 1EW8A 4LREA 4UPIA 4GTXA 1EW9A 3M8WA 3WAXA 1E2SP 1ZEFA 4LR2A 5DLWA 5IJSA 1ZEDA 4LR7A 4LR9A 3BDFA 4B56A 1K7HA 2GLQA 1E1ZP 5C66A 5L0BA 2ANHA 3NKOA 4ZG9A 4LRAA 4CXKA 1FSUA 4ZG7A 3TG0A 5GRRA 1AJAA 1ANIA 3IDDA 5TJ3A 4LRDA 1ALJA 5AJ9A 1O99A 1E33P 1EQJA 5L0EA 4GTWA 3UNYA 3SZYA 5IJQA 4YR1A 2XR9A 3M8ZA 4CXSA 1KHNA 4UORA 4KAYA 3A52A 1KHLA 4KJGA 5L0KA 2IUCA 4GTZA 3DYCA 4LRBA 1EW2A 1ALHA 2D1GA 5DLTA 3WAYA 2XRGA 1URBA 3Q3QA 2IFYA 1ED8A 3ED4A 2GSNA 1AJDA 2W8DA 1N2LA 2W5SA 5LIAA 1ELZA 5K4PA 1Y7AA 3CMRA 2G9YA 3WAWA 4LRCA 4CYSA 3BDGB 1ELYA 3BDHA 5EGEA 3NKPA 4TN0A 4UOOA 3DPCA
chains in the Genus database with same CATH superfamily
3NKRA 3OT9A 4UOPA 3TX0A 2GA3A 2W5WA 1KH5A 4UPKA 5GOVA 1KH7A 5DLVA 1AJCA 1KH9A 4LRFA 5LRMA 3T01A 3T02A 4CXUA 2W5VA 5LRNA 4LR8A 3MK0A 2W5RA 4NWJA 4ZG6A 3WAVA 1O98A 1KHJA 1AUKA 3NKNA 4NWXA 1ANJA 3E2DA 3IGYB 5LQQA 3M7VA 3IGZB 3T00A 2W5TA 4LQYA 3UN2A 1HDHA 5EGHA 3LXQA 3UN5A 1Y6VA 1ED9A 1SHQA 3M8YA 4UPLA 1EI6A 3SZZA 1ALIA 1HJKA 1EJJA 5KXAA 4MIVA 1URAA 3NVLA 2W8SA 3MK1A 5INHA 1HQAA 4UPHA 3UO0A 4KM4A 2W5QA 1P49A 4GTYA 2ZKTA 4N7TA 3NKQA 1ALKA 3BDGA 2VQRA 3TWZA 4CYRA 1AJBA 4MY4A 2QZUA 3WBHA 1B8JA 3UN3A 1N2KA 1KHKA 3NKMA 1E3CP 3MK2A 1KH4A 3B5QA 4QAXA 4FDIA 4KAVA 5HRTA 2RH6A 3KD8A 4ZGAA 1ZEBA 2IUCB 4KJDA 4MHXA 1ELXA 1SHNA 4FDJA 2X98A 2GSUA 2W5XA 2GSOA 1EW8A 4LREA 4UPIA 4GTXA 1EW9A 3M8WA 3WAXA 1E2SP 1ZEFA 4LR2A 5DLWA 5IJSA 1ZEDA 4LR7A 4LR9A 3BDFA 4B56A 1K7HA 2GLQA 1E1ZP 5C66A 5L0BA 2ANHA 3NKOA 4ZG9A 4LRAA 4CXKA 1FSUA 4ZG7A 3TG0A 5GRRA 1AJAA 1ANIA 3IDDA 5TJ3A 4LRDA 1ALJA 5AJ9A 1O99A 1E33P 1EQJA 5L0EA 4GTWA 3UNYA 3SZYA 5IJQA 4YR1A 2XR9A 3M8ZA 4CXSA 1KHNA 4UORA 4KAYA 3A52A 1KHLA 4KJGA 5L0KA 2IUCA 4GTZA 3DYCA 4LRBA 1EW2A 1ALHA 2D1GA 5DLTA 3WAYA 2XRGA 1URBA 3Q3QA 2IFYA 1ED8A 3ED4A 2GSNA 1AJDA 2W8DA 1N2LA 2W5SA 5LIAA 1ELZA 5K4PA 1Y7AA 3CMRA 2G9YA 3WAWA 4LRCA 4CYSA 3BDGB 1ELYA 3BDHA 5EGEA 3NKPA 4TN0A 4UOOA 3DPCA
chains in the Genus database with same CATH topology
3NKRA 3OT9A 4UOPA 3TX0A 2GA3A 2W5WA 1KH5A 4UPKA 5GOVA 1KH7A 5DLVA 1AJCA 1KH9A 4LRFA 5LRMA 3T01A 3T02A 4CXUA 2W5VA 5LRNA 4LR8A 3MK0A 2W5RA 4NWJA 4ZG6A 3WAVA 1O98A 1KHJA 1AUKA 3NKNA 4NWXA 1ANJA 3E2DA 3IGYB 5LQQA 3M7VA 3IGZB 3T00A 2W5TA 4LQYA 3UN2A 1HDHA 5EGHA 3LXQA 3UN5A 1Y6VA 1ED9A 1SHQA 3M8YA 4UPLA 1EI6A 3SZZA 1ALIA 1HJKA 1EJJA 5KXAA 4MIVA 1URAA 3NVLA 2W8SA 3MK1A 5INHA 1HQAA 4UPHA 3UO0A 4KM4A 2W5QA 1P49A 4GTYA 2ZKTA 4N7TA 3NKQA 1ALKA 3BDGA 2VQRA 3TWZA 4CYRA 1AJBA 4MY4A 2QZUA 3WBHA 1B8JA 3UN3A 1N2KA 1KHKA 3NKMA 1E3CP 3MK2A 1KH4A 3B5QA 4QAXA 4FDIA 4KAVA 5HRTA 2RH6A 3KD8A 4ZGAA 1ZEBA 2IUCB 4KJDA 4MHXA 1ELXA 1SHNA 4FDJA 2X98A 2GSUA 2W5XA 2GSOA 1EW8A 4LREA 4UPIA 4GTXA 1EW9A 3M8WA 3WAXA 1E2SP 1ZEFA 4LR2A 5DLWA 5IJSA 1ZEDA 4LR7A 4LR9A 3BDFA 4B56A 1K7HA 2GLQA 1E1ZP 5C66A 5L0BA 2ANHA 3NKOA 4ZG9A 4LRAA 4CXKA 1FSUA 4ZG7A 3TG0A 5GRRA 1AJAA 1ANIA 3IDDA 5TJ3A 4LRDA 1ALJA 5AJ9A 1O99A 1E33P 1EQJA 5L0EA 4GTWA 3UNYA 3SZYA 5IJQA 4YR1A 2XR9A 3M8ZA 4CXSA 1KHNA 4UORA 4KAYA 3A52A 1KHLA 4KJGA 5L0KA 2IUCA 4GTZA 3DYCA 4LRBA 1EW2A 1ALHA 2D1GA 5DLTA 3WAYA 2XRGA 1URBA 3Q3QA 2IFYA 1ED8A 3ED4A 2GSNA 1AJDA 2W8DA 1N2LA 2W5SA 5LIAA 1ELZA 5K4PA 1Y7AA 3CMRA 2G9YA 3WAWA 4LRCA 4CYSA 3BDGB 1ELYA 3BDHA 5EGEA 3NKPA 4TN0A 4UOOA 3DPCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NKR A;  3OT9 A;  4UOP A;  3TX0 A;  2GA3 A;  2W5W A;  1KH5 A;  4UPK A;  5GOV A;  1KH7 A;  5DLV A;  1AJC A;  1KH9 A;  4LRF A;  5LRM A;  3T01 A;  3T02 A;  4CXU A;  2W5V A;  5LRN A;  4LR8 A;  3MK0 A;  2W5R A;  4NWJ A;  4ZG6 A;  3WAV A;  1O98 A;  1KHJ A;  1AUK A;  3NKN A;  4NWX A;  1ANJ A;  3E2D A;  3IGY B;  5LQQ A;  3M7V A;  3IGZ B;  3T00 A;  2W5T A;  4LQY A;  3UN2 A;  1HDH A;  5EGH A;  3LXQ A;  3UN5 A;  1Y6V A;  1ED9 A;  1SHQ A;  3M8Y A;  4UPL A;  1EI6 A;  3SZZ A;  1ALI A;  1HJK A;  1EJJ A;  5KXA A;  4MIV A;  1URA A;  3NVL A;  2W8S A;  3MK1 A;  5INH A;  1HQA A;  4UPH A;  3UO0 A;  4KM4 A;  2W5Q A;  1P49 A;  4GTY A;  2ZKT A;  4N7T A;  3NKQ A;  1ALK A;  3BDG A;  2VQR A;  3TWZ A;  4CYR A;  1AJB A;  4MY4 A;  2QZU A;  3WBH A;  1B8J A;  3UN3 A;  1N2K A;  1KHK A;  3NKM A;  1E3C P;  3MK2 A;  1KH4 A;  3B5Q A;  4QAX A;  4FDI A;  4KAV A;  5HRT A;  2RH6 A;  3KD8 A;  4ZGA A;  1ZEB A;  2IUC B;  4KJD A;  4MHX A;  1ELX A;  1SHN A;  4FDJ A;  2X98 A;  2GSU A;  2W5X A;  2GSO A;  1EW8 A;  4LRE A;  4UPI A;  4GTX A;  1EW9 A;  3M8W A;  3WAX A;  1E2S P;  1ZEF A;  4LR2 A;  5DLW A;  5IJS A;  1ZED A;  4LR7 A;  4LR9 A;  3BDF A;  4B56 A;  1K7H A;  2GLQ A;  1E1Z P;  5C66 A;  5L0B A;  2ANH A;  3NKO A;  4ZG9 A;  4LRA A;  4CXK A;  1FSU A;  4ZG7 A;  3TG0 A;  5GRR A;  1AJA A;  1ANI A;  3IDD A;  5TJ3 A;  4LRD A;  1ALJ A;  5AJ9 A;  1O99 A;  1E33 P;  1EQJ A;  5L0E A;  4GTW A;  3UNY A;  3SZY A;  5IJQ A;  4YR1 A;  2XR9 A;  3M8Z A;  4CXS A;  1KHN A;  4UOR A;  4KAY A;  3A52 A;  1KHL A;  4KJG A;  5L0K A;  2IUC A;  4GTZ A;  3DYC A;  4LRB A;  1EW2 A;  1ALH A;  2D1G A;  5DLT A;  3WAY A;  2XRG A;  1URB A;  3Q3Q A;  2IFY A;  1ED8 A;  3ED4 A;  2GSN A;  1AJD A;  2W8D A;  1N2L A;  2W5S A;  5LIA A;  1ELZ A;  5K4P A;  1Y7A A;  3CMR A;  2G9Y A;  3WAW A;  4LRC A;  4CYS A;  3BDG B;  1ELY A;  3BDH A;  5EGE A;  3NKP A;  4TN0 A;  4UOO A;  3DPC A; 
#chains in the Genus database with same CATH topology
 3NKR A;  3OT9 A;  4UOP A;  3TX0 A;  2GA3 A;  2W5W A;  1KH5 A;  4UPK A;  5GOV A;  1KH7 A;  5DLV A;  1AJC A;  1KH9 A;  4LRF A;  5LRM A;  3T01 A;  3T02 A;  4CXU A;  2W5V A;  5LRN A;  4LR8 A;  3MK0 A;  2W5R A;  4NWJ A;  4ZG6 A;  3WAV A;  1O98 A;  1KHJ A;  1AUK A;  3NKN A;  4NWX A;  1ANJ A;  3E2D A;  3IGY B;  5LQQ A;  3M7V A;  3IGZ B;  3T00 A;  2W5T A;  4LQY A;  3UN2 A;  1HDH A;  5EGH A;  3LXQ A;  3UN5 A;  1Y6V A;  1ED9 A;  1SHQ A;  3M8Y A;  4UPL A;  1EI6 A;  3SZZ A;  1ALI A;  1HJK A;  1EJJ A;  5KXA A;  4MIV A;  1URA A;  3NVL A;  2W8S A;  3MK1 A;  5INH A;  1HQA A;  4UPH A;  3UO0 A;  4KM4 A;  2W5Q A;  1P49 A;  4GTY A;  2ZKT A;  4N7T A;  3NKQ A;  1ALK A;  3BDG A;  2VQR A;  3TWZ A;  4CYR A;  1AJB A;  4MY4 A;  2QZU A;  3WBH A;  1B8J A;  3UN3 A;  1N2K A;  1KHK A;  3NKM A;  1E3C P;  3MK2 A;  1KH4 A;  3B5Q A;  4QAX A;  4FDI A;  4KAV A;  5HRT A;  2RH6 A;  3KD8 A;  4ZGA A;  1ZEB A;  2IUC B;  4KJD A;  4MHX A;  1ELX A;  1SHN A;  4FDJ A;  2X98 A;  2GSU A;  2W5X A;  2GSO A;  1EW8 A;  4LRE A;  4UPI A;  4GTX A;  1EW9 A;  3M8W A;  3WAX A;  1E2S P;  1ZEF A;  4LR2 A;  5DLW A;  5IJS A;  1ZED A;  4LR7 A;  4LR9 A;  3BDF A;  4B56 A;  1K7H A;  2GLQ A;  1E1Z P;  5C66 A;  5L0B A;  2ANH A;  3NKO A;  4ZG9 A;  4LRA A;  4CXK A;  1FSU A;  4ZG7 A;  3TG0 A;  5GRR A;  1AJA A;  1ANI A;  3IDD A;  5TJ3 A;  4LRD A;  1ALJ A;  5AJ9 A;  1O99 A;  1E33 P;  1EQJ A;  5L0E A;  4GTW A;  3UNY A;  3SZY A;  5IJQ A;  4YR1 A;  2XR9 A;  3M8Z A;  4CXS A;  1KHN A;  4UOR A;  4KAY A;  3A52 A;  1KHL A;  4KJG A;  5L0K A;  2IUC A;  4GTZ A;  3DYC A;  4LRB A;  1EW2 A;  1ALH A;  2D1G A;  5DLT A;  3WAY A;  2XRG A;  1URB A;  3Q3Q A;  2IFY A;  1ED8 A;  3ED4 A;  2GSN A;  1AJD A;  2W8D A;  1N2L A;  2W5S A;  5LIA A;  1ELZ A;  5K4P A;  1Y7A A;  3CMR A;  2G9Y A;  3WAW A;  4LRC A;  4CYS A;  3BDG B;  1ELY A;  3BDH A;  5EGE A;  3NKP A;  4TN0 A;  4UOO A;  3DPC A; 
#chains in the Genus database with same CATH homology
 3NKR A;  3OT9 A;  4UOP A;  3TX0 A;  2GA3 A;  2W5W A;  1KH5 A;  4UPK A;  5GOV A;  1KH7 A;  5DLV A;  1AJC A;  1KH9 A;  4LRF A;  5LRM A;  3T01 A;  3T02 A;  4CXU A;  2W5V A;  5LRN A;  4LR8 A;  3MK0 A;  2W5R A;  4NWJ A;  4ZG6 A;  3WAV A;  1O98 A;  1KHJ A;  1AUK A;  3NKN A;  4NWX A;  1ANJ A;  3E2D A;  3IGY B;  5LQQ A;  3M7V A;  3IGZ B;  3T00 A;  2W5T A;  4LQY A;  3UN2 A;  1HDH A;  5EGH A;  3LXQ A;  3UN5 A;  1Y6V A;  1ED9 A;  1SHQ A;  3M8Y A;  4UPL A;  1EI6 A;  3SZZ A;  1ALI A;  1HJK A;  1EJJ A;  5KXA A;  4MIV A;  1URA A;  3NVL A;  2W8S A;  3MK1 A;  5INH A;  1HQA A;  4UPH A;  3UO0 A;  4KM4 A;  2W5Q A;  1P49 A;  4GTY A;  2ZKT A;  4N7T A;  3NKQ A;  1ALK A;  3BDG A;  2VQR A;  3TWZ A;  4CYR A;  1AJB A;  4MY4 A;  2QZU A;  3WBH A;  1B8J A;  3UN3 A;  1N2K A;  1KHK A;  3NKM A;  1E3C P;  3MK2 A;  1KH4 A;  3B5Q A;  4QAX A;  4FDI A;  4KAV A;  5HRT A;  2RH6 A;  3KD8 A;  4ZGA A;  1ZEB A;  2IUC B;  4KJD A;  4MHX A;  1ELX A;  1SHN A;  4FDJ A;  2X98 A;  2GSU A;  2W5X A;  2GSO A;  1EW8 A;  4LRE A;  4UPI A;  4GTX A;  1EW9 A;  3M8W A;  3WAX A;  1E2S P;  1ZEF A;  4LR2 A;  5DLW A;  5IJS A;  1ZED A;  4LR7 A;  4LR9 A;  3BDF A;  4B56 A;  1K7H A;  2GLQ A;  1E1Z P;  5C66 A;  5L0B A;  2ANH A;  3NKO A;  4ZG9 A;  4LRA A;  4CXK A;  1FSU A;  4ZG7 A;  3TG0 A;  5GRR A;  1AJA A;  1ANI A;  3IDD A;  5TJ3 A;  4LRD A;  1ALJ A;  5AJ9 A;  1O99 A;  1E33 P;  1EQJ A;  5L0E A;  4GTW A;  3UNY A;  3SZY A;  5IJQ A;  4YR1 A;  2XR9 A;  3M8Z A;  4CXS A;  1KHN A;  4UOR A;  4KAY A;  3A52 A;  1KHL A;  4KJG A;  5L0K A;  2IUC A;  4GTZ A;  3DYC A;  4LRB A;  1EW2 A;  1ALH A;  2D1G A;  5DLT A;  3WAY A;  2XRG A;  1URB A;  3Q3Q A;  2IFY A;  1ED8 A;  3ED4 A;  2GSN A;  1AJD A;  2W8D A;  1N2L A;  2W5S A;  5LIA A;  1ELZ A;  5K4P A;  1Y7A A;  3CMR A;  2G9Y A;  3WAW A;  4LRC A;  4CYS A;  3BDG B;  1ELY A;  3BDH A;  5EGE A;  3NKP A;  4TN0 A;  4UOO A;  3DPC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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