2GA3A

Structure of s102t e. coli alkaline phosphatase-phosphate intermediate at 2.20a resolution
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
Knots found
sequence length
449
structure length
448
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
molecule tags Hydrolase
source organism Escherichia coli
publication title Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine.
pubmed doi rcsb
total genus 165
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-03-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2ga3A00
1ZEDA 1KH5A 4LR8A 2W5TA 3SZZA 2W5SA 3UN3A 3BDGB 1ANJA 1AJCA 3WAWA 1ZEBA 3MK2A 4NWJA 3NKRA 3WAXA 1HDHA 1O98A 1O99A 2XR9A 3ED4A 5L0EA 5K4PA 2W8DA 1ELXA 1E33P 5EGEA 1KH7A 2GLQA 4LRCA 3M8ZA 2W5QA 1EW8A 2RH6A 3WAVA 4YR1A 1ED9A 3WBHA 4GTYA 3KD8A 3BDHA 1Y7AA 3TG0A 1AJBA 3LXQA 3IDDA 4KAVA 4LR7A 1AJAA 1KHKA 4UPLA 1SHQA 1ED8A 4MHXA 3IGYB 4UPHA 1E3CP 5L0BA 3A52A 2X98A 3NKNA 4ZG9A 4LR2A 4ZGAA 1ELZA 2W5VA 4CXUA 4UOOA 3CMRA 3Q3QA 1Y6VA 2D1GA 4GTXA 3UNYA 4LR9A 5TJ3A 1ANIA 2IUCA 2ZKTA 1B8JA 1EQJA 4CXSA 4GTWA 2GSOA 4KM4A 3BDFA 2G9YA 5DLVA 5LIAA 1EW2A 3UO0A 4UPIA 3T00A 3M8YA 1ZEFA 5DLWA 5KXAA 4CYRA 4LREA 5LRMA 4UOPA 3T02A 5LRNA 1N2KA 1FSUA 1EJJA 5GOVA 1N2LA 4KAYA 3NVLA 1E1ZP 2W5RA 3M7VA 5C66A 5HRTA 2GSUA 5GRRA 1ELYA 3E2DA 2IUCB 5L0KA 1AJDA 1KHLA 2GSNA 4NWXA 1HQAA 5AJ9A 3TWZA 1SHNA 4CXKA 1KHJA 4LRBA 4B56A 3B5QA 3OT9A 3TX0A 3UN2A 4LQYA 2W5XA 1P49A 5IJSA 1ALIA 2ANHA 5DLTA 3T01A 3MK0A 3IGZB 3MK1A 4MY4A 1AUKA 3SZYA 4FDJA 4KJDA 5LQQA 1ALKA 1EW9A 5IJQA 2VQRA 4TN0A 3M8WA 1KH4A 1KH9A 4LRFA 4LRDA 4ZG6A 4FDIA 2QZUA 4GTZA 3NKOA 1EI6A 5INHA 3NKQA 2GA3A 1E2SP 3NKMA 1URAA 1K7HA 3NKPA 1ALHA 1HJKA 1URBA 1ALJA 3DYCA 3UN5A 4CYSA 3DPCA 4KJGA 4MIVA 4LRAA 2XRGA 4ZG7A 2W5WA 2IFYA 4UORA 4N7TA 1KHNA 4UPKA 4QAXA 3BDGA 5EGHA 2W8SA 3WAYA
chains in the Genus database with same CATH superfamily
1ZEDA 1KH5A 4LR8A 2W5TA 3SZZA 2W5SA 3UN3A 3BDGB 1ANJA 1AJCA 3WAWA 1ZEBA 3MK2A 4NWJA 3NKRA 3WAXA 1HDHA 1O98A 1O99A 2XR9A 3ED4A 5L0EA 5K4PA 2W8DA 1ELXA 1E33P 5EGEA 1KH7A 2GLQA 4LRCA 3M8ZA 2W5QA 1EW8A 2RH6A 3WAVA 4YR1A 1ED9A 3WBHA 4GTYA 3KD8A 3BDHA 1Y7AA 3TG0A 1AJBA 3LXQA 3IDDA 4KAVA 4LR7A 1AJAA 1KHKA 4UPLA 1SHQA 1ED8A 4MHXA 3IGYB 4UPHA 1E3CP 5L0BA 3A52A 2X98A 3NKNA 4ZG9A 4LR2A 4ZGAA 1ELZA 2W5VA 4CXUA 4UOOA 3CMRA 3Q3QA 1Y6VA 2D1GA 4GTXA 3UNYA 4LR9A 5TJ3A 1ANIA 2IUCA 2ZKTA 1B8JA 1EQJA 4CXSA 4GTWA 2GSOA 4KM4A 3BDFA 2G9YA 5DLVA 5LIAA 1EW2A 3UO0A 4UPIA 3T00A 3M8YA 1ZEFA 5DLWA 5KXAA 4CYRA 4LREA 5LRMA 4UOPA 3T02A 5LRNA 1N2KA 1FSUA 1EJJA 5GOVA 1N2LA 4KAYA 3NVLA 1E1ZP 2W5RA 3M7VA 5C66A 5HRTA 2GSUA 5GRRA 1ELYA 3E2DA 2IUCB 5L0KA 1AJDA 1KHLA 2GSNA 4NWXA 1HQAA 5AJ9A 3TWZA 1SHNA 4CXKA 1KHJA 4LRBA 4B56A 3B5QA 3OT9A 3TX0A 3UN2A 4LQYA 2W5XA 1P49A 5IJSA 1ALIA 2ANHA 5DLTA 3T01A 3MK0A 3IGZB 3MK1A 4MY4A 1AUKA 3SZYA 4FDJA 4KJDA 5LQQA 1ALKA 1EW9A 5IJQA 2VQRA 4TN0A 3M8WA 1KH4A 1KH9A 4LRFA 4LRDA 4ZG6A 4FDIA 2QZUA 4GTZA 3NKOA 1EI6A 5INHA 3NKQA 2GA3A 1E2SP 3NKMA 1URAA 1K7HA 3NKPA 1ALHA 1HJKA 1URBA 1ALJA 3DYCA 3UN5A 4CYSA 3DPCA 4KJGA 4MIVA 4LRAA 2XRGA 4ZG7A 2W5WA 2IFYA 4UORA 4N7TA 1KHNA 4UPKA 4QAXA 3BDGA 5EGHA 2W8SA 3WAYA
chains in the Genus database with same CATH topology
1ZEDA 1KH5A 4LR8A 2W5TA 3SZZA 2W5SA 3UN3A 3BDGB 1ANJA 1AJCA 3WAWA 1ZEBA 3MK2A 4NWJA 3NKRA 3WAXA 1HDHA 1O98A 1O99A 2XR9A 3ED4A 5L0EA 5K4PA 2W8DA 1ELXA 1E33P 5EGEA 1KH7A 2GLQA 4LRCA 3M8ZA 2W5QA 1EW8A 2RH6A 3WAVA 4YR1A 1ED9A 3WBHA 4GTYA 3KD8A 3BDHA 1Y7AA 3TG0A 1AJBA 3LXQA 3IDDA 4KAVA 4LR7A 1AJAA 1KHKA 4UPLA 1SHQA 1ED8A 4MHXA 3IGYB 4UPHA 1E3CP 5L0BA 3A52A 2X98A 3NKNA 4ZG9A 4LR2A 4ZGAA 1ELZA 2W5VA 4CXUA 4UOOA 3CMRA 3Q3QA 1Y6VA 2D1GA 4GTXA 3UNYA 4LR9A 5TJ3A 1ANIA 2IUCA 2ZKTA 1B8JA 1EQJA 4CXSA 4GTWA 2GSOA 4KM4A 3BDFA 2G9YA 5DLVA 5LIAA 1EW2A 3UO0A 4UPIA 3T00A 3M8YA 1ZEFA 5DLWA 5KXAA 4CYRA 4LREA 5LRMA 4UOPA 3T02A 5LRNA 1N2KA 1FSUA 1EJJA 5GOVA 1N2LA 4KAYA 3NVLA 1E1ZP 2W5RA 3M7VA 5C66A 5HRTA 2GSUA 5GRRA 1ELYA 3E2DA 2IUCB 5L0KA 1AJDA 1KHLA 2GSNA 4NWXA 1HQAA 5AJ9A 3TWZA 1SHNA 4CXKA 1KHJA 4LRBA 4B56A 3B5QA 3OT9A 3TX0A 3UN2A 4LQYA 2W5XA 1P49A 5IJSA 1ALIA 2ANHA 5DLTA 3T01A 3MK0A 3IGZB 3MK1A 4MY4A 1AUKA 3SZYA 4FDJA 4KJDA 5LQQA 1ALKA 1EW9A 5IJQA 2VQRA 4TN0A 3M8WA 1KH4A 1KH9A 4LRFA 4LRDA 4ZG6A 4FDIA 2QZUA 4GTZA 3NKOA 1EI6A 5INHA 3NKQA 2GA3A 1E2SP 3NKMA 1URAA 1K7HA 3NKPA 1ALHA 1HJKA 1URBA 1ALJA 3DYCA 3UN5A 4CYSA 3DPCA 4KJGA 4MIVA 4LRAA 2XRGA 4ZG7A 2W5WA 2IFYA 4UORA 4N7TA 1KHNA 4UPKA 4QAXA 3BDGA 5EGHA 2W8SA 3WAYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZED A;  1KH5 A;  4LR8 A;  2W5T A;  3SZZ A;  2W5S A;  3UN3 A;  3BDG B;  1ANJ A;  1AJC A;  3WAW A;  1ZEB A;  3MK2 A;  4NWJ A;  3NKR A;  3WAX A;  1HDH A;  1O98 A;  1O99 A;  2XR9 A;  3ED4 A;  5L0E A;  5K4P A;  2W8D A;  1ELX A;  1E33 P;  5EGE A;  1KH7 A;  2GLQ A;  4LRC A;  3M8Z A;  2W5Q A;  1EW8 A;  2RH6 A;  3WAV A;  4YR1 A;  1ED9 A;  3WBH A;  4GTY A;  3KD8 A;  3BDH A;  1Y7A A;  3TG0 A;  1AJB A;  3LXQ A;  3IDD A;  4KAV A;  4LR7 A;  1AJA A;  1KHK A;  4UPL A;  1SHQ A;  1ED8 A;  4MHX A;  3IGY B;  4UPH A;  1E3C P;  5L0B A;  3A52 A;  2X98 A;  3NKN A;  4ZG9 A;  4LR2 A;  4ZGA A;  1ELZ A;  2W5V A;  4CXU A;  4UOO A;  3CMR A;  3Q3Q A;  1Y6V A;  2D1G A;  4GTX A;  3UNY A;  4LR9 A;  5TJ3 A;  1ANI A;  2IUC A;  2ZKT A;  1B8J A;  1EQJ A;  4CXS A;  4GTW A;  2GSO A;  4KM4 A;  3BDF A;  2G9Y A;  5DLV A;  5LIA A;  1EW2 A;  3UO0 A;  4UPI A;  3T00 A;  3M8Y A;  1ZEF A;  5DLW A;  5KXA A;  4CYR A;  4LRE A;  5LRM A;  4UOP A;  3T02 A;  5LRN A;  1N2K A;  1FSU A;  1EJJ A;  5GOV A;  1N2L A;  4KAY A;  3NVL A;  1E1Z P;  2W5R A;  3M7V A;  5C66 A;  5HRT A;  2GSU A;  5GRR A;  1ELY A;  3E2D A;  2IUC B;  5L0K A;  1AJD A;  1KHL A;  2GSN A;  4NWX A;  1HQA A;  5AJ9 A;  3TWZ A;  1SHN A;  4CXK A;  1KHJ A;  4LRB A;  4B56 A;  3B5Q A;  3OT9 A;  3TX0 A;  3UN2 A;  4LQY A;  2W5X A;  1P49 A;  5IJS A;  1ALI A;  2ANH A;  5DLT A;  3T01 A;  3MK0 A;  3IGZ B;  3MK1 A;  4MY4 A;  1AUK A;  3SZY A;  4FDJ A;  4KJD A;  5LQQ A;  1ALK A;  1EW9 A;  5IJQ A;  2VQR A;  4TN0 A;  3M8W A;  1KH4 A;  1KH9 A;  4LRF A;  4LRD A;  4ZG6 A;  4FDI A;  2QZU A;  4GTZ A;  3NKO A;  1EI6 A;  5INH A;  3NKQ A;  2GA3 A;  1E2S P;  3NKM A;  1URA A;  1K7H A;  3NKP A;  1ALH A;  1HJK A;  1URB A;  1ALJ A;  3DYC A;  3UN5 A;  4CYS A;  3DPC A;  4KJG A;  4MIV A;  4LRA A;  2XRG A;  4ZG7 A;  2W5W A;  2IFY A;  4UOR A;  4N7T A;  1KHN A;  4UPK A;  4QAX A;  3BDG A;  5EGH A;  2W8S A;  3WAY A; 
#chains in the Genus database with same CATH topology
 1ZED A;  1KH5 A;  4LR8 A;  2W5T A;  3SZZ A;  2W5S A;  3UN3 A;  3BDG B;  1ANJ A;  1AJC A;  3WAW A;  1ZEB A;  3MK2 A;  4NWJ A;  3NKR A;  3WAX A;  1HDH A;  1O98 A;  1O99 A;  2XR9 A;  3ED4 A;  5L0E A;  5K4P A;  2W8D A;  1ELX A;  1E33 P;  5EGE A;  1KH7 A;  2GLQ A;  4LRC A;  3M8Z A;  2W5Q A;  1EW8 A;  2RH6 A;  3WAV A;  4YR1 A;  1ED9 A;  3WBH A;  4GTY A;  3KD8 A;  3BDH A;  1Y7A A;  3TG0 A;  1AJB A;  3LXQ A;  3IDD A;  4KAV A;  4LR7 A;  1AJA A;  1KHK A;  4UPL A;  1SHQ A;  1ED8 A;  4MHX A;  3IGY B;  4UPH A;  1E3C P;  5L0B A;  3A52 A;  2X98 A;  3NKN A;  4ZG9 A;  4LR2 A;  4ZGA A;  1ELZ A;  2W5V A;  4CXU A;  4UOO A;  3CMR A;  3Q3Q A;  1Y6V A;  2D1G A;  4GTX A;  3UNY A;  4LR9 A;  5TJ3 A;  1ANI A;  2IUC A;  2ZKT A;  1B8J A;  1EQJ A;  4CXS A;  4GTW A;  2GSO A;  4KM4 A;  3BDF A;  2G9Y A;  5DLV A;  5LIA A;  1EW2 A;  3UO0 A;  4UPI A;  3T00 A;  3M8Y A;  1ZEF A;  5DLW A;  5KXA A;  4CYR A;  4LRE A;  5LRM A;  4UOP A;  3T02 A;  5LRN A;  1N2K A;  1FSU A;  1EJJ A;  5GOV A;  1N2L A;  4KAY A;  3NVL A;  1E1Z P;  2W5R A;  3M7V A;  5C66 A;  5HRT A;  2GSU A;  5GRR A;  1ELY A;  3E2D A;  2IUC B;  5L0K A;  1AJD A;  1KHL A;  2GSN A;  4NWX A;  1HQA A;  5AJ9 A;  3TWZ A;  1SHN A;  4CXK A;  1KHJ A;  4LRB A;  4B56 A;  3B5Q A;  3OT9 A;  3TX0 A;  3UN2 A;  4LQY A;  2W5X A;  1P49 A;  5IJS A;  1ALI A;  2ANH A;  5DLT A;  3T01 A;  3MK0 A;  3IGZ B;  3MK1 A;  4MY4 A;  1AUK A;  3SZY A;  4FDJ A;  4KJD A;  5LQQ A;  1ALK A;  1EW9 A;  5IJQ A;  2VQR A;  4TN0 A;  3M8W A;  1KH4 A;  1KH9 A;  4LRF A;  4LRD A;  4ZG6 A;  4FDI A;  2QZU A;  4GTZ A;  3NKO A;  1EI6 A;  5INH A;  3NKQ A;  2GA3 A;  1E2S P;  3NKM A;  1URA A;  1K7H A;  3NKP A;  1ALH A;  1HJK A;  1URB A;  1ALJ A;  3DYC A;  3UN5 A;  4CYS A;  3DPC A;  4KJG A;  4MIV A;  4LRA A;  2XRG A;  4ZG7 A;  2W5W A;  2IFY A;  4UOR A;  4N7T A;  1KHN A;  4UPK A;  4QAX A;  3BDG A;  5EGH A;  2W8S A;  3WAY A; 
#chains in the Genus database with same CATH homology
 1ZED A;  1KH5 A;  4LR8 A;  2W5T A;  3SZZ A;  2W5S A;  3UN3 A;  3BDG B;  1ANJ A;  1AJC A;  3WAW A;  1ZEB A;  3MK2 A;  4NWJ A;  3NKR A;  3WAX A;  1HDH A;  1O98 A;  1O99 A;  2XR9 A;  3ED4 A;  5L0E A;  5K4P A;  2W8D A;  1ELX A;  1E33 P;  5EGE A;  1KH7 A;  2GLQ A;  4LRC A;  3M8Z A;  2W5Q A;  1EW8 A;  2RH6 A;  3WAV A;  4YR1 A;  1ED9 A;  3WBH A;  4GTY A;  3KD8 A;  3BDH A;  1Y7A A;  3TG0 A;  1AJB A;  3LXQ A;  3IDD A;  4KAV A;  4LR7 A;  1AJA A;  1KHK A;  4UPL A;  1SHQ A;  1ED8 A;  4MHX A;  3IGY B;  4UPH A;  1E3C P;  5L0B A;  3A52 A;  2X98 A;  3NKN A;  4ZG9 A;  4LR2 A;  4ZGA A;  1ELZ A;  2W5V A;  4CXU A;  4UOO A;  3CMR A;  3Q3Q A;  1Y6V A;  2D1G A;  4GTX A;  3UNY A;  4LR9 A;  5TJ3 A;  1ANI A;  2IUC A;  2ZKT A;  1B8J A;  1EQJ A;  4CXS A;  4GTW A;  2GSO A;  4KM4 A;  3BDF A;  2G9Y A;  5DLV A;  5LIA A;  1EW2 A;  3UO0 A;  4UPI A;  3T00 A;  3M8Y A;  1ZEF A;  5DLW A;  5KXA A;  4CYR A;  4LRE A;  5LRM A;  4UOP A;  3T02 A;  5LRN A;  1N2K A;  1FSU A;  1EJJ A;  5GOV A;  1N2L A;  4KAY A;  3NVL A;  1E1Z P;  2W5R A;  3M7V A;  5C66 A;  5HRT A;  2GSU A;  5GRR A;  1ELY A;  3E2D A;  2IUC B;  5L0K A;  1AJD A;  1KHL A;  2GSN A;  4NWX A;  1HQA A;  5AJ9 A;  3TWZ A;  1SHN A;  4CXK A;  1KHJ A;  4LRB A;  4B56 A;  3B5Q A;  3OT9 A;  3TX0 A;  3UN2 A;  4LQY A;  2W5X A;  1P49 A;  5IJS A;  1ALI A;  2ANH A;  5DLT A;  3T01 A;  3MK0 A;  3IGZ B;  3MK1 A;  4MY4 A;  1AUK A;  3SZY A;  4FDJ A;  4KJD A;  5LQQ A;  1ALK A;  1EW9 A;  5IJQ A;  2VQR A;  4TN0 A;  3M8W A;  1KH4 A;  1KH9 A;  4LRF A;  4LRD A;  4ZG6 A;  4FDI A;  2QZU A;  4GTZ A;  3NKO A;  1EI6 A;  5INH A;  3NKQ A;  2GA3 A;  1E2S P;  3NKM A;  1URA A;  1K7H A;  3NKP A;  1ALH A;  1HJK A;  1URB A;  1ALJ A;  3DYC A;  3UN5 A;  4CYS A;  3DPC A;  4KJG A;  4MIV A;  4LRA A;  2XRG A;  4ZG7 A;  2W5W A;  2IFY A;  4UOR A;  4N7T A;  1KHN A;  4UPK A;  4QAX A;  3BDG A;  5EGH A;  2W8S A;  3WAY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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