2W5VA

Structure of tab5 alkaline phosphatase mutant his 135 asp with mg bound in the m3 site.
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
molecule tags Hydrolase
source organism Antarctic bacterium tab5
total genus 128
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5vA00
3UN5A 3IDDA 1ANIA 3WBHA 3TX0A 4CYRA 3TG0A 2IUCB 1HDHA 5L0KA 4MHXA 1ED8A 3SZZA 1KHKA 1AJCA 2D1GA 3LXQA 5LQQA 2W5QA 1E33P 1URBA 3DPCA 5TJ3A 1AUKA 3NKPA 4KJGA 4LRCA 4NWJA 5K4PA 4UPLA 4LQYA 4QAXA 2GSOA 3NKRA 1EI6A 1B8JA 3NVLA 5DLVA 4MY4A 4LRBA 4LR7A 1SHQA 4UPIA 2W5VA 5L0BA 1KHLA 1N2LA 4UOOA 3UN2A 4GTYA 1E2SP 3NKMA 3M8WA 4YR1A 5GOVA 2ZKTA 5IJQA 1AJBA 3WAVA 4ZG6A 1URAA 5L0EA 1ELYA 1P49A 1KHJA 4LR2A 4FDJA 4LRDA 1E1ZP 3UNYA 1HQAA 2IFYA 3MK2A 5C66A 4N7TA 1EW9A 2GSNA 3DYCA 1ELXA 5GRRA 4LRAA 4CXSA 2W5XA 4FDIA 5LIAA 3MK0A 3ED4A 1ELZA 1EW2A 4UPHA 3M7VA 5AJ9A 5LRMA 4KAYA 3A52A 3BDFA 1ZEDA 4KJDA 4LR8A 4UPKA 3T02A 5KXAA 2W5SA 4NWXA 3BDHA 4CXUA 4B56A 1KH9A 1EJJA 4GTXA 4GTWA 1AJAA 2W8SA 3M8YA 1FSUA 2GLQA 1KH5A 2ANHA 1ED9A 4LR9A 4CXKA 3NKQA 2W5TA 1O98A 5EGEA 3Q3QA 4ZG9A 1E3CP 4LRFA 1ALJA 4TN0A 3IGZB 3WAXA 3NKNA 5IJSA 1ANJA 1HJKA 5LRNA 3T01A 2XRGA 1K7HA 2GSUA 1ALIA 1KH7A 3TWZA 4ZG7A 2W8DA 3T00A 4MIVA 3WAYA 1ZEFA 2XR9A 5INHA 4GTZA 3KD8A 4KM4A 2RH6A 3BDGA 3WAWA 3UO0A 2GA3A 1SHNA 5EGHA 2QZUA 1Y7AA 5DLWA 1ZEBA 2VQRA 3BDGB 3IGYB 2W5WA 4CYSA 1ALHA 5HRTA 4ZGAA 1AJDA 3E2DA 3M8ZA 5DLTA 1ALKA 3UN3A 1KHNA 1KH4A 3MK1A 1O99A 4UORA 3NKOA 3CMRA 1N2KA 4LREA 2G9YA 3B5QA 4UOPA 3SZYA 2W5RA 3OT9A 2X98A 1Y6VA 4KAVA 1EQJA 2IUCA 1EW8A
chains in the Genus database with same CATH superfamily
3UN5A 3IDDA 1ANIA 3WBHA 3TX0A 4CYRA 3TG0A 2IUCB 1HDHA 5L0KA 4MHXA 1ED8A 3SZZA 1KHKA 1AJCA 2D1GA 3LXQA 5LQQA 2W5QA 1E33P 1URBA 3DPCA 5TJ3A 1AUKA 3NKPA 4KJGA 4LRCA 4NWJA 5K4PA 4UPLA 4LQYA 4QAXA 2GSOA 3NKRA 1EI6A 1B8JA 3NVLA 5DLVA 4MY4A 4LRBA 4LR7A 1SHQA 4UPIA 2W5VA 5L0BA 1KHLA 1N2LA 4UOOA 3UN2A 4GTYA 1E2SP 3NKMA 3M8WA 4YR1A 5GOVA 2ZKTA 5IJQA 1AJBA 3WAVA 4ZG6A 1URAA 5L0EA 1ELYA 1P49A 1KHJA 4LR2A 4FDJA 4LRDA 1E1ZP 3UNYA 1HQAA 2IFYA 3MK2A 5C66A 4N7TA 1EW9A 2GSNA 3DYCA 1ELXA 5GRRA 4LRAA 4CXSA 2W5XA 4FDIA 5LIAA 3MK0A 3ED4A 1ELZA 1EW2A 4UPHA 3M7VA 5AJ9A 5LRMA 4KAYA 3A52A 3BDFA 1ZEDA 4KJDA 4LR8A 4UPKA 3T02A 5KXAA 2W5SA 4NWXA 3BDHA 4CXUA 4B56A 1KH9A 1EJJA 4GTXA 4GTWA 1AJAA 2W8SA 3M8YA 1FSUA 2GLQA 1KH5A 2ANHA 1ED9A 4LR9A 4CXKA 3NKQA 2W5TA 1O98A 5EGEA 3Q3QA 4ZG9A 1E3CP 4LRFA 1ALJA 4TN0A 3IGZB 3WAXA 3NKNA 5IJSA 1ANJA 1HJKA 5LRNA 3T01A 2XRGA 1K7HA 2GSUA 1ALIA 1KH7A 3TWZA 4ZG7A 2W8DA 3T00A 4MIVA 3WAYA 1ZEFA 2XR9A 5INHA 4GTZA 3KD8A 4KM4A 2RH6A 3BDGA 3WAWA 3UO0A 2GA3A 1SHNA 5EGHA 2QZUA 1Y7AA 5DLWA 1ZEBA 2VQRA 3BDGB 3IGYB 2W5WA 4CYSA 1ALHA 5HRTA 4ZGAA 1AJDA 3E2DA 3M8ZA 5DLTA 1ALKA 3UN3A 1KHNA 1KH4A 3MK1A 1O99A 4UORA 3NKOA 3CMRA 1N2KA 4LREA 2G9YA 3B5QA 4UOPA 3SZYA 2W5RA 3OT9A 2X98A 1Y6VA 4KAVA 1EQJA 2IUCA 1EW8A
chains in the Genus database with same CATH topology
3UN5A 3IDDA 1ANIA 3WBHA 3TX0A 4CYRA 3TG0A 2IUCB 1HDHA 5L0KA 4MHXA 1ED8A 3SZZA 1KHKA 1AJCA 2D1GA 3LXQA 5LQQA 2W5QA 1E33P 1URBA 3DPCA 5TJ3A 1AUKA 3NKPA 4KJGA 4LRCA 4NWJA 5K4PA 4UPLA 4LQYA 4QAXA 2GSOA 3NKRA 1EI6A 1B8JA 3NVLA 5DLVA 4MY4A 4LRBA 4LR7A 1SHQA 4UPIA 2W5VA 5L0BA 1KHLA 1N2LA 4UOOA 3UN2A 4GTYA 1E2SP 3NKMA 3M8WA 4YR1A 5GOVA 2ZKTA 5IJQA 1AJBA 3WAVA 4ZG6A 1URAA 5L0EA 1ELYA 1P49A 1KHJA 4LR2A 4FDJA 4LRDA 1E1ZP 3UNYA 1HQAA 2IFYA 3MK2A 5C66A 4N7TA 1EW9A 2GSNA 3DYCA 1ELXA 5GRRA 4LRAA 4CXSA 2W5XA 4FDIA 5LIAA 3MK0A 3ED4A 1ELZA 1EW2A 4UPHA 3M7VA 5AJ9A 5LRMA 4KAYA 3A52A 3BDFA 1ZEDA 4KJDA 4LR8A 4UPKA 3T02A 5KXAA 2W5SA 4NWXA 3BDHA 4CXUA 4B56A 1KH9A 1EJJA 4GTXA 4GTWA 1AJAA 2W8SA 3M8YA 1FSUA 2GLQA 1KH5A 2ANHA 1ED9A 4LR9A 4CXKA 3NKQA 2W5TA 1O98A 5EGEA 3Q3QA 4ZG9A 1E3CP 4LRFA 1ALJA 4TN0A 3IGZB 3WAXA 3NKNA 5IJSA 1ANJA 1HJKA 5LRNA 3T01A 2XRGA 1K7HA 2GSUA 1ALIA 1KH7A 3TWZA 4ZG7A 2W8DA 3T00A 4MIVA 3WAYA 1ZEFA 2XR9A 5INHA 4GTZA 3KD8A 4KM4A 2RH6A 3BDGA 3WAWA 3UO0A 2GA3A 1SHNA 5EGHA 2QZUA 1Y7AA 5DLWA 1ZEBA 2VQRA 3BDGB 3IGYB 2W5WA 4CYSA 1ALHA 5HRTA 4ZGAA 1AJDA 3E2DA 3M8ZA 5DLTA 1ALKA 3UN3A 1KHNA 1KH4A 3MK1A 1O99A 4UORA 3NKOA 3CMRA 1N2KA 4LREA 2G9YA 3B5QA 4UOPA 3SZYA 2W5RA 3OT9A 2X98A 1Y6VA 4KAVA 1EQJA 2IUCA 1EW8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UN5 A;  3IDD A;  1ANI A;  3WBH A;  3TX0 A;  4CYR A;  3TG0 A;  2IUC B;  1HDH A;  5L0K A;  4MHX A;  1ED8 A;  3SZZ A;  1KHK A;  1AJC A;  2D1G A;  3LXQ A;  5LQQ A;  2W5Q A;  1E33 P;  1URB A;  3DPC A;  5TJ3 A;  1AUK A;  3NKP A;  4KJG A;  4LRC A;  4NWJ A;  5K4P A;  4UPL A;  4LQY A;  4QAX A;  2GSO A;  3NKR A;  1EI6 A;  1B8J A;  3NVL A;  5DLV A;  4MY4 A;  4LRB A;  4LR7 A;  1SHQ A;  4UPI A;  2W5V A;  5L0B A;  1KHL A;  1N2L A;  4UOO A;  3UN2 A;  4GTY A;  1E2S P;  3NKM A;  3M8W A;  4YR1 A;  5GOV A;  2ZKT A;  5IJQ A;  1AJB A;  3WAV A;  4ZG6 A;  1URA A;  5L0E A;  1ELY A;  1P49 A;  1KHJ A;  4LR2 A;  4FDJ A;  4LRD A;  1E1Z P;  3UNY A;  1HQA A;  2IFY A;  3MK2 A;  5C66 A;  4N7T A;  1EW9 A;  2GSN A;  3DYC A;  1ELX A;  5GRR A;  4LRA A;  4CXS A;  2W5X A;  4FDI A;  5LIA A;  3MK0 A;  3ED4 A;  1ELZ A;  1EW2 A;  4UPH A;  3M7V A;  5AJ9 A;  5LRM A;  4KAY A;  3A52 A;  3BDF A;  1ZED A;  4KJD A;  4LR8 A;  4UPK A;  3T02 A;  5KXA A;  2W5S A;  4NWX A;  3BDH A;  4CXU A;  4B56 A;  1KH9 A;  1EJJ A;  4GTX A;  4GTW A;  1AJA A;  2W8S A;  3M8Y A;  1FSU A;  2GLQ A;  1KH5 A;  2ANH A;  1ED9 A;  4LR9 A;  4CXK A;  3NKQ A;  2W5T A;  1O98 A;  5EGE A;  3Q3Q A;  4ZG9 A;  1E3C P;  4LRF A;  1ALJ A;  4TN0 A;  3IGZ B;  3WAX A;  3NKN A;  5IJS A;  1ANJ A;  1HJK A;  5LRN A;  3T01 A;  2XRG A;  1K7H A;  2GSU A;  1ALI A;  1KH7 A;  3TWZ A;  4ZG7 A;  2W8D A;  3T00 A;  4MIV A;  3WAY A;  1ZEF A;  2XR9 A;  5INH A;  4GTZ A;  3KD8 A;  4KM4 A;  2RH6 A;  3BDG A;  3WAW A;  3UO0 A;  2GA3 A;  1SHN A;  5EGH A;  2QZU A;  1Y7A A;  5DLW A;  1ZEB A;  2VQR A;  3BDG B;  3IGY B;  2W5W A;  4CYS A;  1ALH A;  5HRT A;  4ZGA A;  1AJD A;  3E2D A;  3M8Z A;  5DLT A;  1ALK A;  3UN3 A;  1KHN A;  1KH4 A;  3MK1 A;  1O99 A;  4UOR A;  3NKO A;  3CMR A;  1N2K A;  4LRE A;  2G9Y A;  3B5Q A;  4UOP A;  3SZY A;  2W5R A;  3OT9 A;  2X98 A;  1Y6V A;  4KAV A;  1EQJ A;  2IUC A;  1EW8 A; 
#chains in the Genus database with same CATH topology
 3UN5 A;  3IDD A;  1ANI A;  3WBH A;  3TX0 A;  4CYR A;  3TG0 A;  2IUC B;  1HDH A;  5L0K A;  4MHX A;  1ED8 A;  3SZZ A;  1KHK A;  1AJC A;  2D1G A;  3LXQ A;  5LQQ A;  2W5Q A;  1E33 P;  1URB A;  3DPC A;  5TJ3 A;  1AUK A;  3NKP A;  4KJG A;  4LRC A;  4NWJ A;  5K4P A;  4UPL A;  4LQY A;  4QAX A;  2GSO A;  3NKR A;  1EI6 A;  1B8J A;  3NVL A;  5DLV A;  4MY4 A;  4LRB A;  4LR7 A;  1SHQ A;  4UPI A;  2W5V A;  5L0B A;  1KHL A;  1N2L A;  4UOO A;  3UN2 A;  4GTY A;  1E2S P;  3NKM A;  3M8W A;  4YR1 A;  5GOV A;  2ZKT A;  5IJQ A;  1AJB A;  3WAV A;  4ZG6 A;  1URA A;  5L0E A;  1ELY A;  1P49 A;  1KHJ A;  4LR2 A;  4FDJ A;  4LRD A;  1E1Z P;  3UNY A;  1HQA A;  2IFY A;  3MK2 A;  5C66 A;  4N7T A;  1EW9 A;  2GSN A;  3DYC A;  1ELX A;  5GRR A;  4LRA A;  4CXS A;  2W5X A;  4FDI A;  5LIA A;  3MK0 A;  3ED4 A;  1ELZ A;  1EW2 A;  4UPH A;  3M7V A;  5AJ9 A;  5LRM A;  4KAY A;  3A52 A;  3BDF A;  1ZED A;  4KJD A;  4LR8 A;  4UPK A;  3T02 A;  5KXA A;  2W5S A;  4NWX A;  3BDH A;  4CXU A;  4B56 A;  1KH9 A;  1EJJ A;  4GTX A;  4GTW A;  1AJA A;  2W8S A;  3M8Y A;  1FSU A;  2GLQ A;  1KH5 A;  2ANH A;  1ED9 A;  4LR9 A;  4CXK A;  3NKQ A;  2W5T A;  1O98 A;  5EGE A;  3Q3Q A;  4ZG9 A;  1E3C P;  4LRF A;  1ALJ A;  4TN0 A;  3IGZ B;  3WAX A;  3NKN A;  5IJS A;  1ANJ A;  1HJK A;  5LRN A;  3T01 A;  2XRG A;  1K7H A;  2GSU A;  1ALI A;  1KH7 A;  3TWZ A;  4ZG7 A;  2W8D A;  3T00 A;  4MIV A;  3WAY A;  1ZEF A;  2XR9 A;  5INH A;  4GTZ A;  3KD8 A;  4KM4 A;  2RH6 A;  3BDG A;  3WAW A;  3UO0 A;  2GA3 A;  1SHN A;  5EGH A;  2QZU A;  1Y7A A;  5DLW A;  1ZEB A;  2VQR A;  3BDG B;  3IGY B;  2W5W A;  4CYS A;  1ALH A;  5HRT A;  4ZGA A;  1AJD A;  3E2D A;  3M8Z A;  5DLT A;  1ALK A;  3UN3 A;  1KHN A;  1KH4 A;  3MK1 A;  1O99 A;  4UOR A;  3NKO A;  3CMR A;  1N2K A;  4LRE A;  2G9Y A;  3B5Q A;  4UOP A;  3SZY A;  2W5R A;  3OT9 A;  2X98 A;  1Y6V A;  4KAV A;  1EQJ A;  2IUC A;  1EW8 A; 
#chains in the Genus database with same CATH homology
 3UN5 A;  3IDD A;  1ANI A;  3WBH A;  3TX0 A;  4CYR A;  3TG0 A;  2IUC B;  1HDH A;  5L0K A;  4MHX A;  1ED8 A;  3SZZ A;  1KHK A;  1AJC A;  2D1G A;  3LXQ A;  5LQQ A;  2W5Q A;  1E33 P;  1URB A;  3DPC A;  5TJ3 A;  1AUK A;  3NKP A;  4KJG A;  4LRC A;  4NWJ A;  5K4P A;  4UPL A;  4LQY A;  4QAX A;  2GSO A;  3NKR A;  1EI6 A;  1B8J A;  3NVL A;  5DLV A;  4MY4 A;  4LRB A;  4LR7 A;  1SHQ A;  4UPI A;  2W5V A;  5L0B A;  1KHL A;  1N2L A;  4UOO A;  3UN2 A;  4GTY A;  1E2S P;  3NKM A;  3M8W A;  4YR1 A;  5GOV A;  2ZKT A;  5IJQ A;  1AJB A;  3WAV A;  4ZG6 A;  1URA A;  5L0E A;  1ELY A;  1P49 A;  1KHJ A;  4LR2 A;  4FDJ A;  4LRD A;  1E1Z P;  3UNY A;  1HQA A;  2IFY A;  3MK2 A;  5C66 A;  4N7T A;  1EW9 A;  2GSN A;  3DYC A;  1ELX A;  5GRR A;  4LRA A;  4CXS A;  2W5X A;  4FDI A;  5LIA A;  3MK0 A;  3ED4 A;  1ELZ A;  1EW2 A;  4UPH A;  3M7V A;  5AJ9 A;  5LRM A;  4KAY A;  3A52 A;  3BDF A;  1ZED A;  4KJD A;  4LR8 A;  4UPK A;  3T02 A;  5KXA A;  2W5S A;  4NWX A;  3BDH A;  4CXU A;  4B56 A;  1KH9 A;  1EJJ A;  4GTX A;  4GTW A;  1AJA A;  2W8S A;  3M8Y A;  1FSU A;  2GLQ A;  1KH5 A;  2ANH A;  1ED9 A;  4LR9 A;  4CXK A;  3NKQ A;  2W5T A;  1O98 A;  5EGE A;  3Q3Q A;  4ZG9 A;  1E3C P;  4LRF A;  1ALJ A;  4TN0 A;  3IGZ B;  3WAX A;  3NKN A;  5IJS A;  1ANJ A;  1HJK A;  5LRN A;  3T01 A;  2XRG A;  1K7H A;  2GSU A;  1ALI A;  1KH7 A;  3TWZ A;  4ZG7 A;  2W8D A;  3T00 A;  4MIV A;  3WAY A;  1ZEF A;  2XR9 A;  5INH A;  4GTZ A;  3KD8 A;  4KM4 A;  2RH6 A;  3BDG A;  3WAW A;  3UO0 A;  2GA3 A;  1SHN A;  5EGH A;  2QZU A;  1Y7A A;  5DLW A;  1ZEB A;  2VQR A;  3BDG B;  3IGY B;  2W5W A;  4CYS A;  1ALH A;  5HRT A;  4ZGA A;  1AJD A;  3E2D A;  3M8Z A;  5DLT A;  1ALK A;  3UN3 A;  1KHN A;  1KH4 A;  3MK1 A;  1O99 A;  4UOR A;  3NKO A;  3CMR A;  1N2K A;  4LRE A;  2G9Y A;  3B5Q A;  4UOP A;  3SZY A;  2W5R A;  3OT9 A;  2X98 A;  1Y6V A;  4KAV A;  1EQJ A;  2IUC A;  1EW8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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