3MK0A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 178
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk0A00
1ZEFA 3MK2A 4KM4A 1Y7AA 1ALKA 4MIVA 1EQJA 1KH4A 1AJBA 4GTZA 4NWJA 5LQQA 1SHNA 4UOOA 3NKQA 1E1ZP 2X98A 2ZKTA 4KJDA 5IJQA 1URBA 5L0EA 1KHNA 3BDFA 4MHXA 3WAYA 3MK1A 3SZYA 5AJ9A 1EW9A 4UPIA 1KH5A 4NWXA 3WBHA 5KXAA 3NVLA 1HJKA 5L0BA 5TJ3A 4UPLA 1O98A 2XRGA 1KHKA 4LREA 3TWZA 4GTXA 3UN2A 1ELXA 3UN5A 4CXSA 3OT9A 3UO0A 4ZG7A 1HQAA 5LIAA 3MK0A 3LXQA 4UPKA 2GA3A 4LRBA 4FDIA 3WAVA 1P49A 3NKMA 2ANHA 5GRRA 5GOVA 1E33P 1N2LA 5LRNA 4ZG9A 4CXKA 4FDJA 5K4PA 5LRMA 1E3CP 3SZZA 2G9YA 2W5RA 1ZEBA 3T01A 1ED9A 1E2SP 5DLVA 3NKNA 4MY4A 4UPHA 1N2KA 4LR7A 3M7VA 2VQRA 5DLWA 3M8WA 1SHQA 1O99A 2GLQA 1EI6A 4LR9A 1ALHA 1KHJA 5DLTA 2GSOA 4ZG6A 1AJDA 4LRDA 5EGEA 1FSUA 4LRAA 4CYRA 4QAXA 2W5WA 3UN3A 5C66A 1ELZA 1ANIA 4LRCA 2IFYA 1KH7A 1HDHA 2W5VA 2QZUA 3BDGB 3IDDA 1ALJA 4LRFA 3BDGA 4LR8A 4KAYA 3T02A 1ELYA 1ALIA 3IGYB 5HRTA 3CMRA 4TN0A 3M8YA 2GSUA 2W5QA 1EW8A 1B8JA 1KH9A 4UORA 3T00A 2IUCB 5IJSA 2D1GA 2RH6A 1AJCA 5L0KA 3TX0A 3E2DA 2IUCA 3DPCA 3B5QA 4YR1A 4KAVA 5INHA 4LQYA 4CYSA 4CXUA 4B56A 3KD8A 1K7HA 1ZEDA 2XR9A 3WAXA 3BDHA 4GTYA 4UOPA 5EGHA 2W8SA 3TG0A 4KJGA 1URAA 2W5XA 3DYCA 1Y6VA 3ED4A 3NKOA 1AJAA 1ANJA 3NKPA 3M8ZA 3Q3QA 4LR2A 3UNYA 1AUKA 1KHLA 2W8DA 4N7TA 1EW2A 3NKRA 4GTWA 1ED8A 3A52A 2W5TA 1EJJA 2W5SA 3WAWA 3IGZB 2GSNA 4ZGAA
chains in the Genus database with same CATH superfamily
1ZEFA 3MK2A 4KM4A 1Y7AA 1ALKA 4MIVA 1EQJA 1KH4A 1AJBA 4GTZA 4NWJA 5LQQA 1SHNA 4UOOA 3NKQA 1E1ZP 2X98A 2ZKTA 4KJDA 5IJQA 1URBA 5L0EA 1KHNA 3BDFA 4MHXA 3WAYA 3MK1A 3SZYA 5AJ9A 1EW9A 4UPIA 1KH5A 4NWXA 3WBHA 5KXAA 3NVLA 1HJKA 5L0BA 5TJ3A 4UPLA 1O98A 2XRGA 1KHKA 4LREA 3TWZA 4GTXA 3UN2A 1ELXA 3UN5A 4CXSA 3OT9A 3UO0A 4ZG7A 1HQAA 5LIAA 3MK0A 3LXQA 4UPKA 2GA3A 4LRBA 4FDIA 3WAVA 1P49A 3NKMA 2ANHA 5GRRA 5GOVA 1E33P 1N2LA 5LRNA 4ZG9A 4CXKA 4FDJA 5K4PA 5LRMA 1E3CP 3SZZA 2G9YA 2W5RA 1ZEBA 3T01A 1ED9A 1E2SP 5DLVA 3NKNA 4MY4A 4UPHA 1N2KA 4LR7A 3M7VA 2VQRA 5DLWA 3M8WA 1SHQA 1O99A 2GLQA 1EI6A 4LR9A 1ALHA 1KHJA 5DLTA 2GSOA 4ZG6A 1AJDA 4LRDA 5EGEA 1FSUA 4LRAA 4CYRA 4QAXA 2W5WA 3UN3A 5C66A 1ELZA 1ANIA 4LRCA 2IFYA 1KH7A 1HDHA 2W5VA 2QZUA 3BDGB 3IDDA 1ALJA 4LRFA 3BDGA 4LR8A 4KAYA 3T02A 1ELYA 1ALIA 3IGYB 5HRTA 3CMRA 4TN0A 3M8YA 2GSUA 2W5QA 1EW8A 1B8JA 1KH9A 4UORA 3T00A 2IUCB 5IJSA 2D1GA 2RH6A 1AJCA 5L0KA 3TX0A 3E2DA 2IUCA 3DPCA 3B5QA 4YR1A 4KAVA 5INHA 4LQYA 4CYSA 4CXUA 4B56A 3KD8A 1K7HA 1ZEDA 2XR9A 3WAXA 3BDHA 4GTYA 4UOPA 5EGHA 2W8SA 3TG0A 4KJGA 1URAA 2W5XA 3DYCA 1Y6VA 3ED4A 3NKOA 1AJAA 1ANJA 3NKPA 3M8ZA 3Q3QA 4LR2A 3UNYA 1AUKA 1KHLA 2W8DA 4N7TA 1EW2A 3NKRA 4GTWA 1ED8A 3A52A 2W5TA 1EJJA 2W5SA 3WAWA 3IGZB 2GSNA 4ZGAA
chains in the Genus database with same CATH topology
1ZEFA 3MK2A 4KM4A 1Y7AA 1ALKA 4MIVA 1EQJA 1KH4A 1AJBA 4GTZA 4NWJA 5LQQA 1SHNA 4UOOA 3NKQA 1E1ZP 2X98A 2ZKTA 4KJDA 5IJQA 1URBA 5L0EA 1KHNA 3BDFA 4MHXA 3WAYA 3MK1A 3SZYA 5AJ9A 1EW9A 4UPIA 1KH5A 4NWXA 3WBHA 5KXAA 3NVLA 1HJKA 5L0BA 5TJ3A 4UPLA 1O98A 2XRGA 1KHKA 4LREA 3TWZA 4GTXA 3UN2A 1ELXA 3UN5A 4CXSA 3OT9A 3UO0A 4ZG7A 1HQAA 5LIAA 3MK0A 3LXQA 4UPKA 2GA3A 4LRBA 4FDIA 3WAVA 1P49A 3NKMA 2ANHA 5GRRA 5GOVA 1E33P 1N2LA 5LRNA 4ZG9A 4CXKA 4FDJA 5K4PA 5LRMA 1E3CP 3SZZA 2G9YA 2W5RA 1ZEBA 3T01A 1ED9A 1E2SP 5DLVA 3NKNA 4MY4A 4UPHA 1N2KA 4LR7A 3M7VA 2VQRA 5DLWA 3M8WA 1SHQA 1O99A 2GLQA 1EI6A 4LR9A 1ALHA 1KHJA 5DLTA 2GSOA 4ZG6A 1AJDA 4LRDA 5EGEA 1FSUA 4LRAA 4CYRA 4QAXA 2W5WA 3UN3A 5C66A 1ELZA 1ANIA 4LRCA 2IFYA 1KH7A 1HDHA 2W5VA 2QZUA 3BDGB 3IDDA 1ALJA 4LRFA 3BDGA 4LR8A 4KAYA 3T02A 1ELYA 1ALIA 3IGYB 5HRTA 3CMRA 4TN0A 3M8YA 2GSUA 2W5QA 1EW8A 1B8JA 1KH9A 4UORA 3T00A 2IUCB 5IJSA 2D1GA 2RH6A 1AJCA 5L0KA 3TX0A 3E2DA 2IUCA 3DPCA 3B5QA 4YR1A 4KAVA 5INHA 4LQYA 4CYSA 4CXUA 4B56A 3KD8A 1K7HA 1ZEDA 2XR9A 3WAXA 3BDHA 4GTYA 4UOPA 5EGHA 2W8SA 3TG0A 4KJGA 1URAA 2W5XA 3DYCA 1Y6VA 3ED4A 3NKOA 1AJAA 1ANJA 3NKPA 3M8ZA 3Q3QA 4LR2A 3UNYA 1AUKA 1KHLA 2W8DA 4N7TA 1EW2A 3NKRA 4GTWA 1ED8A 3A52A 2W5TA 1EJJA 2W5SA 3WAWA 3IGZB 2GSNA 4ZGAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEF A;  3MK2 A;  4KM4 A;  1Y7A A;  1ALK A;  4MIV A;  1EQJ A;  1KH4 A;  1AJB A;  4GTZ A;  4NWJ A;  5LQQ A;  1SHN A;  4UOO A;  3NKQ A;  1E1Z P;  2X98 A;  2ZKT A;  4KJD A;  5IJQ A;  1URB A;  5L0E A;  1KHN A;  3BDF A;  4MHX A;  3WAY A;  3MK1 A;  3SZY A;  5AJ9 A;  1EW9 A;  4UPI A;  1KH5 A;  4NWX A;  3WBH A;  5KXA A;  3NVL A;  1HJK A;  5L0B A;  5TJ3 A;  4UPL A;  1O98 A;  2XRG A;  1KHK A;  4LRE A;  3TWZ A;  4GTX A;  3UN2 A;  1ELX A;  3UN5 A;  4CXS A;  3OT9 A;  3UO0 A;  4ZG7 A;  1HQA A;  5LIA A;  3MK0 A;  3LXQ A;  4UPK A;  2GA3 A;  4LRB A;  4FDI A;  3WAV A;  1P49 A;  3NKM A;  2ANH A;  5GRR A;  5GOV A;  1E33 P;  1N2L A;  5LRN A;  4ZG9 A;  4CXK A;  4FDJ A;  5K4P A;  5LRM A;  1E3C P;  3SZZ A;  2G9Y A;  2W5R A;  1ZEB A;  3T01 A;  1ED9 A;  1E2S P;  5DLV A;  3NKN A;  4MY4 A;  4UPH A;  1N2K A;  4LR7 A;  3M7V A;  2VQR A;  5DLW A;  3M8W A;  1SHQ A;  1O99 A;  2GLQ A;  1EI6 A;  4LR9 A;  1ALH A;  1KHJ A;  5DLT A;  2GSO A;  4ZG6 A;  1AJD A;  4LRD A;  5EGE A;  1FSU A;  4LRA A;  4CYR A;  4QAX A;  2W5W A;  3UN3 A;  5C66 A;  1ELZ A;  1ANI A;  4LRC A;  2IFY A;  1KH7 A;  1HDH A;  2W5V A;  2QZU A;  3BDG B;  3IDD A;  1ALJ A;  4LRF A;  3BDG A;  4LR8 A;  4KAY A;  3T02 A;  1ELY A;  1ALI A;  3IGY B;  5HRT A;  3CMR A;  4TN0 A;  3M8Y A;  2GSU A;  2W5Q A;  1EW8 A;  1B8J A;  1KH9 A;  4UOR A;  3T00 A;  2IUC B;  5IJS A;  2D1G A;  2RH6 A;  1AJC A;  5L0K A;  3TX0 A;  3E2D A;  2IUC A;  3DPC A;  3B5Q A;  4YR1 A;  4KAV A;  5INH A;  4LQY A;  4CYS A;  4CXU A;  4B56 A;  3KD8 A;  1K7H A;  1ZED A;  2XR9 A;  3WAX A;  3BDH A;  4GTY A;  4UOP A;  5EGH A;  2W8S A;  3TG0 A;  4KJG A;  1URA A;  2W5X A;  3DYC A;  1Y6V A;  3ED4 A;  3NKO A;  1AJA A;  1ANJ A;  3NKP A;  3M8Z A;  3Q3Q A;  4LR2 A;  3UNY A;  1AUK A;  1KHL A;  2W8D A;  4N7T A;  1EW2 A;  3NKR A;  4GTW A;  1ED8 A;  3A52 A;  2W5T A;  1EJJ A;  2W5S A;  3WAW A;  3IGZ B;  2GSN A;  4ZGA A; 
#chains in the Genus database with same CATH topology
 1ZEF A;  3MK2 A;  4KM4 A;  1Y7A A;  1ALK A;  4MIV A;  1EQJ A;  1KH4 A;  1AJB A;  4GTZ A;  4NWJ A;  5LQQ A;  1SHN A;  4UOO A;  3NKQ A;  1E1Z P;  2X98 A;  2ZKT A;  4KJD A;  5IJQ A;  1URB A;  5L0E A;  1KHN A;  3BDF A;  4MHX A;  3WAY A;  3MK1 A;  3SZY A;  5AJ9 A;  1EW9 A;  4UPI A;  1KH5 A;  4NWX A;  3WBH A;  5KXA A;  3NVL A;  1HJK A;  5L0B A;  5TJ3 A;  4UPL A;  1O98 A;  2XRG A;  1KHK A;  4LRE A;  3TWZ A;  4GTX A;  3UN2 A;  1ELX A;  3UN5 A;  4CXS A;  3OT9 A;  3UO0 A;  4ZG7 A;  1HQA A;  5LIA A;  3MK0 A;  3LXQ A;  4UPK A;  2GA3 A;  4LRB A;  4FDI A;  3WAV A;  1P49 A;  3NKM A;  2ANH A;  5GRR A;  5GOV A;  1E33 P;  1N2L A;  5LRN A;  4ZG9 A;  4CXK A;  4FDJ A;  5K4P A;  5LRM A;  1E3C P;  3SZZ A;  2G9Y A;  2W5R A;  1ZEB A;  3T01 A;  1ED9 A;  1E2S P;  5DLV A;  3NKN A;  4MY4 A;  4UPH A;  1N2K A;  4LR7 A;  3M7V A;  2VQR A;  5DLW A;  3M8W A;  1SHQ A;  1O99 A;  2GLQ A;  1EI6 A;  4LR9 A;  1ALH A;  1KHJ A;  5DLT A;  2GSO A;  4ZG6 A;  1AJD A;  4LRD A;  5EGE A;  1FSU A;  4LRA A;  4CYR A;  4QAX A;  2W5W A;  3UN3 A;  5C66 A;  1ELZ A;  1ANI A;  4LRC A;  2IFY A;  1KH7 A;  1HDH A;  2W5V A;  2QZU A;  3BDG B;  3IDD A;  1ALJ A;  4LRF A;  3BDG A;  4LR8 A;  4KAY A;  3T02 A;  1ELY A;  1ALI A;  3IGY B;  5HRT A;  3CMR A;  4TN0 A;  3M8Y A;  2GSU A;  2W5Q A;  1EW8 A;  1B8J A;  1KH9 A;  4UOR A;  3T00 A;  2IUC B;  5IJS A;  2D1G A;  2RH6 A;  1AJC A;  5L0K A;  3TX0 A;  3E2D A;  2IUC A;  3DPC A;  3B5Q A;  4YR1 A;  4KAV A;  5INH A;  4LQY A;  4CYS A;  4CXU A;  4B56 A;  3KD8 A;  1K7H A;  1ZED A;  2XR9 A;  3WAX A;  3BDH A;  4GTY A;  4UOP A;  5EGH A;  2W8S A;  3TG0 A;  4KJG A;  1URA A;  2W5X A;  3DYC A;  1Y6V A;  3ED4 A;  3NKO A;  1AJA A;  1ANJ A;  3NKP A;  3M8Z A;  3Q3Q A;  4LR2 A;  3UNY A;  1AUK A;  1KHL A;  2W8D A;  4N7T A;  1EW2 A;  3NKR A;  4GTW A;  1ED8 A;  3A52 A;  2W5T A;  1EJJ A;  2W5S A;  3WAW A;  3IGZ B;  2GSN A;  4ZGA A; 
#chains in the Genus database with same CATH homology
 1ZEF A;  3MK2 A;  4KM4 A;  1Y7A A;  1ALK A;  4MIV A;  1EQJ A;  1KH4 A;  1AJB A;  4GTZ A;  4NWJ A;  5LQQ A;  1SHN A;  4UOO A;  3NKQ A;  1E1Z P;  2X98 A;  2ZKT A;  4KJD A;  5IJQ A;  1URB A;  5L0E A;  1KHN A;  3BDF A;  4MHX A;  3WAY A;  3MK1 A;  3SZY A;  5AJ9 A;  1EW9 A;  4UPI A;  1KH5 A;  4NWX A;  3WBH A;  5KXA A;  3NVL A;  1HJK A;  5L0B A;  5TJ3 A;  4UPL A;  1O98 A;  2XRG A;  1KHK A;  4LRE A;  3TWZ A;  4GTX A;  3UN2 A;  1ELX A;  3UN5 A;  4CXS A;  3OT9 A;  3UO0 A;  4ZG7 A;  1HQA A;  5LIA A;  3MK0 A;  3LXQ A;  4UPK A;  2GA3 A;  4LRB A;  4FDI A;  3WAV A;  1P49 A;  3NKM A;  2ANH A;  5GRR A;  5GOV A;  1E33 P;  1N2L A;  5LRN A;  4ZG9 A;  4CXK A;  4FDJ A;  5K4P A;  5LRM A;  1E3C P;  3SZZ A;  2G9Y A;  2W5R A;  1ZEB A;  3T01 A;  1ED9 A;  1E2S P;  5DLV A;  3NKN A;  4MY4 A;  4UPH A;  1N2K A;  4LR7 A;  3M7V A;  2VQR A;  5DLW A;  3M8W A;  1SHQ A;  1O99 A;  2GLQ A;  1EI6 A;  4LR9 A;  1ALH A;  1KHJ A;  5DLT A;  2GSO A;  4ZG6 A;  1AJD A;  4LRD A;  5EGE A;  1FSU A;  4LRA A;  4CYR A;  4QAX A;  2W5W A;  3UN3 A;  5C66 A;  1ELZ A;  1ANI A;  4LRC A;  2IFY A;  1KH7 A;  1HDH A;  2W5V A;  2QZU A;  3BDG B;  3IDD A;  1ALJ A;  4LRF A;  3BDG A;  4LR8 A;  4KAY A;  3T02 A;  1ELY A;  1ALI A;  3IGY B;  5HRT A;  3CMR A;  4TN0 A;  3M8Y A;  2GSU A;  2W5Q A;  1EW8 A;  1B8J A;  1KH9 A;  4UOR A;  3T00 A;  2IUC B;  5IJS A;  2D1G A;  2RH6 A;  1AJC A;  5L0K A;  3TX0 A;  3E2D A;  2IUC A;  3DPC A;  3B5Q A;  4YR1 A;  4KAV A;  5INH A;  4LQY A;  4CYS A;  4CXU A;  4B56 A;  3KD8 A;  1K7H A;  1ZED A;  2XR9 A;  3WAX A;  3BDH A;  4GTY A;  4UOP A;  5EGH A;  2W8S A;  3TG0 A;  4KJG A;  1URA A;  2W5X A;  3DYC A;  1Y6V A;  3ED4 A;  3NKO A;  1AJA A;  1ANJ A;  3NKP A;  3M8Z A;  3Q3Q A;  4LR2 A;  3UNY A;  1AUK A;  1KHL A;  2W8D A;  4N7T A;  1EW2 A;  3NKR A;  4GTW A;  1ED8 A;  3A52 A;  2W5T A;  1EJJ A;  2W5S A;  3WAW A;  3IGZ B;  2GSN A;  4ZGA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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