3MK1A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule keywords Alkaline phosphatase, placental type
total genus 180
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk1A00
2GSUA 2W5SA 4GTWA 2IUCA 2W8SA 4UPIA 4KJGA 3T01A 4ZG6A 5L0EA 2D1GA 5L0KA 3BDGB 3DYCA 2ANHA 5LRNA 1Y7AA 1KHJA 3BDFA 4MIVA 4KAVA 1Y6VA 1ZEDA 2IFYA 3A52A 4UPLA 3TWZA 4N7TA 1HJKA 1KHKA 5LIAA 5LQQA 3M8WA 2XR9A 4NWJA 4KM4A 1ALJA 3WAXA 4LQYA 2W5WA 3NKNA 3OT9A 4KAYA 1SHQA 4ZG9A 2RH6A 4LRAA 3UN5A 1ALHA 1HQAA 3MK2A 4FDJA 1ED8A 3DPCA 1HDHA 1ANIA 4ZGAA 4ZG7A 2IUCB 5DLTA 3UO0A 2W5RA 4LRFA 1N2KA 5C66A 1ELZA 1O98A 3UN3A 2X98A 5IJQA 3M8YA 3Q3QA 3IDDA 4MHXA 4UPHA 4LRBA 4CYSA 3TG0A 2G9YA 2GA3A 3ED4A 3IGYB 1E2SP 5LRMA 3TX0A 1EW9A 3CMRA 1ALKA 1N2LA 3M8ZA 1E1ZP 1K7HA 4LR8A 1ANJA 2W8DA 3SZYA 4CXUA 1ED9A 2XRGA 1FSUA 3E2DA 2ZKTA 3MK1A 2W5VA 3WAVA 4B56A 3WAYA 5GRRA 5INHA 4CXSA 1KH9A 5HRTA 1KHNA 1KHLA 1AJBA 3NKPA 3UN2A 4MY4A 1KH5A 5DLWA 1EJJA 4CXKA 4LRDA 4KJDA 1AJDA 3NKMA 4LRCA 4UOPA 5IJSA 3T02A 1ALIA 1URAA 1O99A 2W5XA 5GOVA 1ZEFA 2W5QA 4LR2A 2GSOA 4YR1A 3WAWA 4FDIA 5EGHA 4UORA 4GTZA 4GTYA 4GTXA 3UNYA 5TJ3A 2GSNA 3B5QA 3M7VA 1EQJA 3MK0A 1EW8A 1EI6A 1E33P 3BDHA 2VQRA 4TN0A 5DLVA 4QAXA 5EGEA 4UOOA 3NKQA 1E3CP 1AJCA 4UPKA 3SZZA 3BDGA 1EW2A 4LR9A 3KD8A 5AJ9A 1KH4A 1SHNA 5L0BA 5K4PA 1URBA 4CYRA 1ZEBA 1AJAA 3T00A 2QZUA 2GLQA 4LR7A 3NKOA 1AUKA 3WBHA 1P49A 3IGZB 3NKRA 5KXAA 1ELYA 1KH7A 3NVLA 1B8JA 2W5TA 3LXQA 4NWXA 1ELXA 4LREA
chains in the Genus database with same CATH superfamily
2GSUA 2W5SA 4GTWA 2IUCA 2W8SA 4UPIA 4KJGA 3T01A 4ZG6A 5L0EA 2D1GA 5L0KA 3BDGB 3DYCA 2ANHA 5LRNA 1Y7AA 1KHJA 3BDFA 4MIVA 4KAVA 1Y6VA 1ZEDA 2IFYA 3A52A 4UPLA 3TWZA 4N7TA 1HJKA 1KHKA 5LIAA 5LQQA 3M8WA 2XR9A 4NWJA 4KM4A 1ALJA 3WAXA 4LQYA 2W5WA 3NKNA 3OT9A 4KAYA 1SHQA 4ZG9A 2RH6A 4LRAA 3UN5A 1ALHA 1HQAA 3MK2A 4FDJA 1ED8A 3DPCA 1HDHA 1ANIA 4ZGAA 4ZG7A 2IUCB 5DLTA 3UO0A 2W5RA 4LRFA 1N2KA 5C66A 1ELZA 1O98A 3UN3A 2X98A 5IJQA 3M8YA 3Q3QA 3IDDA 4MHXA 4UPHA 4LRBA 4CYSA 3TG0A 2G9YA 2GA3A 3ED4A 3IGYB 1E2SP 5LRMA 3TX0A 1EW9A 3CMRA 1ALKA 1N2LA 3M8ZA 1E1ZP 1K7HA 4LR8A 1ANJA 2W8DA 3SZYA 4CXUA 1ED9A 2XRGA 1FSUA 3E2DA 2ZKTA 3MK1A 2W5VA 3WAVA 4B56A 3WAYA 5GRRA 5INHA 4CXSA 1KH9A 5HRTA 1KHNA 1KHLA 1AJBA 3NKPA 3UN2A 4MY4A 1KH5A 5DLWA 1EJJA 4CXKA 4LRDA 4KJDA 1AJDA 3NKMA 4LRCA 4UOPA 5IJSA 3T02A 1ALIA 1URAA 1O99A 2W5XA 5GOVA 1ZEFA 2W5QA 4LR2A 2GSOA 4YR1A 3WAWA 4FDIA 5EGHA 4UORA 4GTZA 4GTYA 4GTXA 3UNYA 5TJ3A 2GSNA 3B5QA 3M7VA 1EQJA 3MK0A 1EW8A 1EI6A 1E33P 3BDHA 2VQRA 4TN0A 5DLVA 4QAXA 5EGEA 4UOOA 3NKQA 1E3CP 1AJCA 4UPKA 3SZZA 3BDGA 1EW2A 4LR9A 3KD8A 5AJ9A 1KH4A 1SHNA 5L0BA 5K4PA 1URBA 4CYRA 1ZEBA 1AJAA 3T00A 2QZUA 2GLQA 4LR7A 3NKOA 1AUKA 3WBHA 1P49A 3IGZB 3NKRA 5KXAA 1ELYA 1KH7A 3NVLA 1B8JA 2W5TA 3LXQA 4NWXA 1ELXA 4LREA
chains in the Genus database with same CATH topology
2GSUA 2W5SA 4GTWA 2IUCA 2W8SA 4UPIA 4KJGA 3T01A 4ZG6A 5L0EA 2D1GA 5L0KA 3BDGB 3DYCA 2ANHA 5LRNA 1Y7AA 1KHJA 3BDFA 4MIVA 4KAVA 1Y6VA 1ZEDA 2IFYA 3A52A 4UPLA 3TWZA 4N7TA 1HJKA 1KHKA 5LIAA 5LQQA 3M8WA 2XR9A 4NWJA 4KM4A 1ALJA 3WAXA 4LQYA 2W5WA 3NKNA 3OT9A 4KAYA 1SHQA 4ZG9A 2RH6A 4LRAA 3UN5A 1ALHA 1HQAA 3MK2A 4FDJA 1ED8A 3DPCA 1HDHA 1ANIA 4ZGAA 4ZG7A 2IUCB 5DLTA 3UO0A 2W5RA 4LRFA 1N2KA 5C66A 1ELZA 1O98A 3UN3A 2X98A 5IJQA 3M8YA 3Q3QA 3IDDA 4MHXA 4UPHA 4LRBA 4CYSA 3TG0A 2G9YA 2GA3A 3ED4A 3IGYB 1E2SP 5LRMA 3TX0A 1EW9A 3CMRA 1ALKA 1N2LA 3M8ZA 1E1ZP 1K7HA 4LR8A 1ANJA 2W8DA 3SZYA 4CXUA 1ED9A 2XRGA 1FSUA 3E2DA 2ZKTA 3MK1A 2W5VA 3WAVA 4B56A 3WAYA 5GRRA 5INHA 4CXSA 1KH9A 5HRTA 1KHNA 1KHLA 1AJBA 3NKPA 3UN2A 4MY4A 1KH5A 5DLWA 1EJJA 4CXKA 4LRDA 4KJDA 1AJDA 3NKMA 4LRCA 4UOPA 5IJSA 3T02A 1ALIA 1URAA 1O99A 2W5XA 5GOVA 1ZEFA 2W5QA 4LR2A 2GSOA 4YR1A 3WAWA 4FDIA 5EGHA 4UORA 4GTZA 4GTYA 4GTXA 3UNYA 5TJ3A 2GSNA 3B5QA 3M7VA 1EQJA 3MK0A 1EW8A 1EI6A 1E33P 3BDHA 2VQRA 4TN0A 5DLVA 4QAXA 5EGEA 4UOOA 3NKQA 1E3CP 1AJCA 4UPKA 3SZZA 3BDGA 1EW2A 4LR9A 3KD8A 5AJ9A 1KH4A 1SHNA 5L0BA 5K4PA 1URBA 4CYRA 1ZEBA 1AJAA 3T00A 2QZUA 2GLQA 4LR7A 3NKOA 1AUKA 3WBHA 1P49A 3IGZB 3NKRA 5KXAA 1ELYA 1KH7A 3NVLA 1B8JA 2W5TA 3LXQA 4NWXA 1ELXA 4LREA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GSU A;  2W5S A;  4GTW A;  2IUC A;  2W8S A;  4UPI A;  4KJG A;  3T01 A;  4ZG6 A;  5L0E A;  2D1G A;  5L0K A;  3BDG B;  3DYC A;  2ANH A;  5LRN A;  1Y7A A;  1KHJ A;  3BDF A;  4MIV A;  4KAV A;  1Y6V A;  1ZED A;  2IFY A;  3A52 A;  4UPL A;  3TWZ A;  4N7T A;  1HJK A;  1KHK A;  5LIA A;  5LQQ A;  3M8W A;  2XR9 A;  4NWJ A;  4KM4 A;  1ALJ A;  3WAX A;  4LQY A;  2W5W A;  3NKN A;  3OT9 A;  4KAY A;  1SHQ A;  4ZG9 A;  2RH6 A;  4LRA A;  3UN5 A;  1ALH A;  1HQA A;  3MK2 A;  4FDJ A;  1ED8 A;  3DPC A;  1HDH A;  1ANI A;  4ZGA A;  4ZG7 A;  2IUC B;  5DLT A;  3UO0 A;  2W5R A;  4LRF A;  1N2K A;  5C66 A;  1ELZ A;  1O98 A;  3UN3 A;  2X98 A;  5IJQ A;  3M8Y A;  3Q3Q A;  3IDD A;  4MHX A;  4UPH A;  4LRB A;  4CYS A;  3TG0 A;  2G9Y A;  2GA3 A;  3ED4 A;  3IGY B;  1E2S P;  5LRM A;  3TX0 A;  1EW9 A;  3CMR A;  1ALK A;  1N2L A;  3M8Z A;  1E1Z P;  1K7H A;  4LR8 A;  1ANJ A;  2W8D A;  3SZY A;  4CXU A;  1ED9 A;  2XRG A;  1FSU A;  3E2D A;  2ZKT A;  3MK1 A;  2W5V A;  3WAV A;  4B56 A;  3WAY A;  5GRR A;  5INH A;  4CXS A;  1KH9 A;  5HRT A;  1KHN A;  1KHL A;  1AJB A;  3NKP A;  3UN2 A;  4MY4 A;  1KH5 A;  5DLW A;  1EJJ A;  4CXK A;  4LRD A;  4KJD A;  1AJD A;  3NKM A;  4LRC A;  4UOP A;  5IJS A;  3T02 A;  1ALI A;  1URA A;  1O99 A;  2W5X A;  5GOV A;  1ZEF A;  2W5Q A;  4LR2 A;  2GSO A;  4YR1 A;  3WAW A;  4FDI A;  5EGH A;  4UOR A;  4GTZ A;  4GTY A;  4GTX A;  3UNY A;  5TJ3 A;  2GSN A;  3B5Q A;  3M7V A;  1EQJ A;  3MK0 A;  1EW8 A;  1EI6 A;  1E33 P;  3BDH A;  2VQR A;  4TN0 A;  5DLV A;  4QAX A;  5EGE A;  4UOO A;  3NKQ A;  1E3C P;  1AJC A;  4UPK A;  3SZZ A;  3BDG A;  1EW2 A;  4LR9 A;  3KD8 A;  5AJ9 A;  1KH4 A;  1SHN A;  5L0B A;  5K4P A;  1URB A;  4CYR A;  1ZEB A;  1AJA A;  3T00 A;  2QZU A;  2GLQ A;  4LR7 A;  3NKO A;  1AUK A;  3WBH A;  1P49 A;  3IGZ B;  3NKR A;  5KXA A;  1ELY A;  1KH7 A;  3NVL A;  1B8J A;  2W5T A;  3LXQ A;  4NWX A;  1ELX A;  4LRE A; 
#chains in the Genus database with same CATH topology
 2GSU A;  2W5S A;  4GTW A;  2IUC A;  2W8S A;  4UPI A;  4KJG A;  3T01 A;  4ZG6 A;  5L0E A;  2D1G A;  5L0K A;  3BDG B;  3DYC A;  2ANH A;  5LRN A;  1Y7A A;  1KHJ A;  3BDF A;  4MIV A;  4KAV A;  1Y6V A;  1ZED A;  2IFY A;  3A52 A;  4UPL A;  3TWZ A;  4N7T A;  1HJK A;  1KHK A;  5LIA A;  5LQQ A;  3M8W A;  2XR9 A;  4NWJ A;  4KM4 A;  1ALJ A;  3WAX A;  4LQY A;  2W5W A;  3NKN A;  3OT9 A;  4KAY A;  1SHQ A;  4ZG9 A;  2RH6 A;  4LRA A;  3UN5 A;  1ALH A;  1HQA A;  3MK2 A;  4FDJ A;  1ED8 A;  3DPC A;  1HDH A;  1ANI A;  4ZGA A;  4ZG7 A;  2IUC B;  5DLT A;  3UO0 A;  2W5R A;  4LRF A;  1N2K A;  5C66 A;  1ELZ A;  1O98 A;  3UN3 A;  2X98 A;  5IJQ A;  3M8Y A;  3Q3Q A;  3IDD A;  4MHX A;  4UPH A;  4LRB A;  4CYS A;  3TG0 A;  2G9Y A;  2GA3 A;  3ED4 A;  3IGY B;  1E2S P;  5LRM A;  3TX0 A;  1EW9 A;  3CMR A;  1ALK A;  1N2L A;  3M8Z A;  1E1Z P;  1K7H A;  4LR8 A;  1ANJ A;  2W8D A;  3SZY A;  4CXU A;  1ED9 A;  2XRG A;  1FSU A;  3E2D A;  2ZKT A;  3MK1 A;  2W5V A;  3WAV A;  4B56 A;  3WAY A;  5GRR A;  5INH A;  4CXS A;  1KH9 A;  5HRT A;  1KHN A;  1KHL A;  1AJB A;  3NKP A;  3UN2 A;  4MY4 A;  1KH5 A;  5DLW A;  1EJJ A;  4CXK A;  4LRD A;  4KJD A;  1AJD A;  3NKM A;  4LRC A;  4UOP A;  5IJS A;  3T02 A;  1ALI A;  1URA A;  1O99 A;  2W5X A;  5GOV A;  1ZEF A;  2W5Q A;  4LR2 A;  2GSO A;  4YR1 A;  3WAW A;  4FDI A;  5EGH A;  4UOR A;  4GTZ A;  4GTY A;  4GTX A;  3UNY A;  5TJ3 A;  2GSN A;  3B5Q A;  3M7V A;  1EQJ A;  3MK0 A;  1EW8 A;  1EI6 A;  1E33 P;  3BDH A;  2VQR A;  4TN0 A;  5DLV A;  4QAX A;  5EGE A;  4UOO A;  3NKQ A;  1E3C P;  1AJC A;  4UPK A;  3SZZ A;  3BDG A;  1EW2 A;  4LR9 A;  3KD8 A;  5AJ9 A;  1KH4 A;  1SHN A;  5L0B A;  5K4P A;  1URB A;  4CYR A;  1ZEB A;  1AJA A;  3T00 A;  2QZU A;  2GLQ A;  4LR7 A;  3NKO A;  1AUK A;  3WBH A;  1P49 A;  3IGZ B;  3NKR A;  5KXA A;  1ELY A;  1KH7 A;  3NVL A;  1B8J A;  2W5T A;  3LXQ A;  4NWX A;  1ELX A;  4LRE A; 
#chains in the Genus database with same CATH homology
 2GSU A;  2W5S A;  4GTW A;  2IUC A;  2W8S A;  4UPI A;  4KJG A;  3T01 A;  4ZG6 A;  5L0E A;  2D1G A;  5L0K A;  3BDG B;  3DYC A;  2ANH A;  5LRN A;  1Y7A A;  1KHJ A;  3BDF A;  4MIV A;  4KAV A;  1Y6V A;  1ZED A;  2IFY A;  3A52 A;  4UPL A;  3TWZ A;  4N7T A;  1HJK A;  1KHK A;  5LIA A;  5LQQ A;  3M8W A;  2XR9 A;  4NWJ A;  4KM4 A;  1ALJ A;  3WAX A;  4LQY A;  2W5W A;  3NKN A;  3OT9 A;  4KAY A;  1SHQ A;  4ZG9 A;  2RH6 A;  4LRA A;  3UN5 A;  1ALH A;  1HQA A;  3MK2 A;  4FDJ A;  1ED8 A;  3DPC A;  1HDH A;  1ANI A;  4ZGA A;  4ZG7 A;  2IUC B;  5DLT A;  3UO0 A;  2W5R A;  4LRF A;  1N2K A;  5C66 A;  1ELZ A;  1O98 A;  3UN3 A;  2X98 A;  5IJQ A;  3M8Y A;  3Q3Q A;  3IDD A;  4MHX A;  4UPH A;  4LRB A;  4CYS A;  3TG0 A;  2G9Y A;  2GA3 A;  3ED4 A;  3IGY B;  1E2S P;  5LRM A;  3TX0 A;  1EW9 A;  3CMR A;  1ALK A;  1N2L A;  3M8Z A;  1E1Z P;  1K7H A;  4LR8 A;  1ANJ A;  2W8D A;  3SZY A;  4CXU A;  1ED9 A;  2XRG A;  1FSU A;  3E2D A;  2ZKT A;  3MK1 A;  2W5V A;  3WAV A;  4B56 A;  3WAY A;  5GRR A;  5INH A;  4CXS A;  1KH9 A;  5HRT A;  1KHN A;  1KHL A;  1AJB A;  3NKP A;  3UN2 A;  4MY4 A;  1KH5 A;  5DLW A;  1EJJ A;  4CXK A;  4LRD A;  4KJD A;  1AJD A;  3NKM A;  4LRC A;  4UOP A;  5IJS A;  3T02 A;  1ALI A;  1URA A;  1O99 A;  2W5X A;  5GOV A;  1ZEF A;  2W5Q A;  4LR2 A;  2GSO A;  4YR1 A;  3WAW A;  4FDI A;  5EGH A;  4UOR A;  4GTZ A;  4GTY A;  4GTX A;  3UNY A;  5TJ3 A;  2GSN A;  3B5Q A;  3M7V A;  1EQJ A;  3MK0 A;  1EW8 A;  1EI6 A;  1E33 P;  3BDH A;  2VQR A;  4TN0 A;  5DLV A;  4QAX A;  5EGE A;  4UOO A;  3NKQ A;  1E3C P;  1AJC A;  4UPK A;  3SZZ A;  3BDG A;  1EW2 A;  4LR9 A;  3KD8 A;  5AJ9 A;  1KH4 A;  1SHN A;  5L0B A;  5K4P A;  1URB A;  4CYR A;  1ZEB A;  1AJA A;  3T00 A;  2QZU A;  2GLQ A;  4LR7 A;  3NKO A;  1AUK A;  3WBH A;  1P49 A;  3IGZ B;  3NKR A;  5KXA A;  1ELY A;  1KH7 A;  3NVL A;  1B8J A;  2W5T A;  3LXQ A;  4NWX A;  1ELX A;  4LRE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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