3MK1 | Genus

Total Genus 180

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	180
Knots found	KnotProt 2.0: S +3₁
sequence length	481
structure length	480
Chain Sequence	IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
publication title	Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site. pubmed doi rcsb
molecule keywords	Alkaline phosphatase, placental type
total genus	180
structure length	480
sequence length	481
other databases	KnotProt 2.0: S +3₁
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2010-04-13

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	3mk1A00

1O98A 2W5RA 4CXKA 4LR2A 5DLVA 2IFYA 4KJDA 2VQRA 1ANIA 1KHKA 1K7HA 4FDIA 1N2LA 3T02A 3WAVA 2QZUA 3TG0A 1KH4A 1EW8A 2W8DA 3UNYA 2IUCB 4LRCA 1HDHA 3B5QA 4CXSA 4UOPA 1E33P 2GSOA 4ZGAA 2ZKTA 3MK0A 2GSUA 5LRMA 5EGEA 3BDFA 5L0KA 4ZG9A 4UPKA 4LRBA 4MY4A 3WBHA 4LR9A 1P49A 5K4PA 3NKMA 1ALHA 1Y6VA 5C66A 3BDHA 4TN0A 1EQJA 4KAYA 1KH5A 2W5WA 1E1ZP 4KM4A 1ELYA 3UN2A 1FSUA 3MK1A 1KH7A 3IDDA 2GSNA 4LRDA 3BDGA 1AJDA 3TX0A 1SHQA 3NKNA 3UO0A 4CYRA 1ELZA 5AJ9A 1AJBA 5GOVA 3WAXA 3SZYA 3SZZA 4FDJA 5IJQA 3Q3QA 1AJAA 1B8JA 4CXUA 5HRTA 4UORA 2RH6A 3NVLA 4CYSA 4YR1A 4MHXA 1EI6A 2GLQA 3M8ZA 2X98A 1EW9A 4UPIA 4UPHA 1N2KA 1ALJA 3A52A 2ANHA 2D1GA 1ALKA 4GTXA 2G9YA 1E2SP 1HJKA 2W5TA 3DPCA 4MIVA 1AUKA 4LQYA 5IJSA 1ANJA 1E3CP 2GA3A 5LIAA 3BDGB 4UOOA 1URAA 3E2DA 5TJ3A 3UN5A 3LXQA 3M7VA 3IGYB 4B56A 2XRGA 4LRAA 1URBA 5KXAA 4GTWA 5LRNA 3OT9A 1HQAA 1ELXA 3DYCA 3WAWA 3IGZB 4GTYA 3NKQA 5L0BA 4QAXA 1Y7AA 2W5SA 3KD8A 1ZEFA 3CMRA 3UN3A 4ZG7A 3TWZA 2W5XA 1KHLA 1ZEDA 3T00A 2W5VA 4NWJA 3M8YA 5EGHA 5LQQA 4LREA 3NKOA 5DLWA 2W5QA 3NKRA 2W8SA 4LR7A 1KHJA 4LRFA 3NKPA 4GTZA 5INHA 5DLTA 1KH9A 4N7TA 2XR9A 1EJJA 3T01A 2IUCA 1AJCA 1SHNA 3MK2A 4ZG6A 1ED9A 5L0EA 1ZEBA 1O99A 4LR8A 4KAVA 3WAYA 3ED4A 4NWXA 4UPLA 1EW2A 1KHNA 5GRRA 1ED8A 4KJGA 1ALIA 3M8WA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1O98 A;  2W5R A;  4CXK A;  4LR2 A;  5DLV A;  2IFY A;  4KJD A;  2VQR A;  1ANI A;  1KHK A;  1K7H A;  4FDI A;  1N2L A;  3T02 A;  3WAV A;  2QZU A;  3TG0 A;  1KH4 A;  1EW8 A;  2W8D A;  3UNY A;  2IUC B;  4LRC A;  1HDH A;  3B5Q A;  4CXS A;  4UOP A;  1E33 P;  2GSO A;  4ZGA A;  2ZKT A;  3MK0 A;  2GSU A;  5LRM A;  5EGE A;  3BDF A;  5L0K A;  4ZG9 A;  4UPK A;  4LRB A;  4MY4 A;  3WBH A;  4LR9 A;  1P49 A;  5K4P A;  3NKM A;  1ALH A;  1Y6V A;  5C66 A;  3BDH A;  4TN0 A;  1EQJ A;  4KAY A;  1KH5 A;  2W5W A;  1E1Z P;  4KM4 A;  1ELY A;  3UN2 A;  1FSU A;  3MK1 A;  1KH7 A;  3IDD A;  2GSN A;  4LRD A;  3BDG A;  1AJD A;  3TX0 A;  1SHQ A;  3NKN A;  3UO0 A;  4CYR A;  1ELZ A;  5AJ9 A;  1AJB A;  5GOV A;  3WAX A;  3SZY A;  3SZZ A;  4FDJ A;  5IJQ A;  3Q3Q A;  1AJA A;  1B8J A;  4CXU A;  5HRT A;  4UOR A;  2RH6 A;  3NVL A;  4CYS A;  4YR1 A;  4MHX A;  1EI6 A;  2GLQ A;  3M8Z A;  2X98 A;  1EW9 A;  4UPI A;  4UPH A;  1N2K A;  1ALJ A;  3A52 A;  2ANH A;  2D1G A;  1ALK A;  4GTX A;  2G9Y A;  1E2S P;  1HJK A;  2W5T A;  3DPC A;  4MIV A;  1AUK A;  4LQY A;  5IJS A;  1ANJ A;  1E3C P;  2GA3 A;  5LIA A;  3BDG B;  4UOO A;  1URA A;  3E2D A;  5TJ3 A;  3UN5 A;  3LXQ A;  3M7V A;  3IGY B;  4B56 A;  2XRG A;  4LRA A;  1URB A;  5KXA A;  4GTW A;  5LRN A;  3OT9 A;  1HQA A;  1ELX A;  3DYC A;  3WAW A;  3IGZ B;  4GTY A;  3NKQ A;  5L0B A;  4QAX A;  1Y7A A;  2W5S A;  3KD8 A;  1ZEF A;  3CMR A;  3UN3 A;  4ZG7 A;  3TWZ A;  2W5X A;  1KHL A;  1ZED A;  3T00 A;  2W5V A;  4NWJ A;  3M8Y A;  5EGH A;  5LQQ A;  4LRE A;  3NKO A;  5DLW A;  2W5Q A;  3NKR A;  2W8S A;  4LR7 A;  1KHJ A;  4LRF A;  3NKP A;  4GTZ A;  5INH A;  5DLT A;  1KH9 A;  4N7T A;  2XR9 A;  1EJJ A;  3T01 A;  2IUC A;  1AJC A;  1SHN A;  3MK2 A;  4ZG6 A;  1ED9 A;  5L0E A;  1ZEB A;  1O99 A;  4LR8 A;  4KAV A;  3WAY A;  3ED4 A;  4NWX A;  4UPL A;  1EW2 A;  1KHN A;  5GRR A;  1ED8 A;  4KJG A;  1ALI A;  3M8W A; 
#chains in the Genus database with same CATH topology
 1O98 A;  2W5R A;  4CXK A;  4LR2 A;  5DLV A;  2IFY A;  4KJD A;  2VQR A;  1ANI A;  1KHK A;  1K7H A;  4FDI A;  1N2L A;  3T02 A;  3WAV A;  2QZU A;  3TG0 A;  1KH4 A;  1EW8 A;  2W8D A;  3UNY A;  2IUC B;  4LRC A;  1HDH A;  3B5Q A;  4CXS A;  4UOP A;  1E33 P;  2GSO A;  4ZGA A;  2ZKT A;  3MK0 A;  2GSU A;  5LRM A;  5EGE A;  3BDF A;  5L0K A;  4ZG9 A;  4UPK A;  4LRB A;  4MY4 A;  3WBH A;  4LR9 A;  1P49 A;  5K4P A;  3NKM A;  1ALH A;  1Y6V A;  5C66 A;  3BDH A;  4TN0 A;  1EQJ A;  4KAY A;  1KH5 A;  2W5W A;  1E1Z P;  4KM4 A;  1ELY A;  3UN2 A;  1FSU A;  3MK1 A;  1KH7 A;  3IDD A;  2GSN A;  4LRD A;  3BDG A;  1AJD A;  3TX0 A;  1SHQ A;  3NKN A;  3UO0 A;  4CYR A;  1ELZ A;  5AJ9 A;  1AJB A;  5GOV A;  3WAX A;  3SZY A;  3SZZ A;  4FDJ A;  5IJQ A;  3Q3Q A;  1AJA A;  1B8J A;  4CXU A;  5HRT A;  4UOR A;  2RH6 A;  3NVL A;  4CYS A;  4YR1 A;  4MHX A;  1EI6 A;  2GLQ A;  3M8Z A;  2X98 A;  1EW9 A;  4UPI A;  4UPH A;  1N2K A;  1ALJ A;  3A52 A;  2ANH A;  2D1G A;  1ALK A;  4GTX A;  2G9Y A;  1E2S P;  1HJK A;  2W5T A;  3DPC A;  4MIV A;  1AUK A;  4LQY A;  5IJS A;  1ANJ A;  1E3C P;  2GA3 A;  5LIA A;  3BDG B;  4UOO A;  1URA A;  3E2D A;  5TJ3 A;  3UN5 A;  3LXQ A;  3M7V A;  3IGY B;  4B56 A;  2XRG A;  4LRA A;  1URB A;  5KXA A;  4GTW A;  5LRN A;  3OT9 A;  1HQA A;  1ELX A;  3DYC A;  3WAW A;  3IGZ B;  4GTY A;  3NKQ A;  5L0B A;  4QAX A;  1Y7A A;  2W5S A;  3KD8 A;  1ZEF A;  3CMR A;  3UN3 A;  4ZG7 A;  3TWZ A;  2W5X A;  1KHL A;  1ZED A;  3T00 A;  2W5V A;  4NWJ A;  3M8Y A;  5EGH A;  5LQQ A;  4LRE A;  3NKO A;  5DLW A;  2W5Q A;  3NKR A;  2W8S A;  4LR7 A;  1KHJ A;  4LRF A;  3NKP A;  4GTZ A;  5INH A;  5DLT A;  1KH9 A;  4N7T A;  2XR9 A;  1EJJ A;  3T01 A;  2IUC A;  1AJC A;  1SHN A;  3MK2 A;  4ZG6 A;  1ED9 A;  5L0E A;  1ZEB A;  1O99 A;  4LR8 A;  4KAV A;  3WAY A;  3ED4 A;  4NWX A;  4UPL A;  1EW2 A;  1KHN A;  5GRR A;  1ED8 A;  4KJG A;  1ALI A;  3M8W A; 
#chains in the Genus database with same CATH homology
 1O98 A;  2W5R A;  4CXK A;  4LR2 A;  5DLV A;  2IFY A;  4KJD A;  2VQR A;  1ANI A;  1KHK A;  1K7H A;  4FDI A;  1N2L A;  3T02 A;  3WAV A;  2QZU A;  3TG0 A;  1KH4 A;  1EW8 A;  2W8D A;  3UNY A;  2IUC B;  4LRC A;  1HDH A;  3B5Q A;  4CXS A;  4UOP A;  1E33 P;  2GSO A;  4ZGA A;  2ZKT A;  3MK0 A;  2GSU A;  5LRM A;  5EGE A;  3BDF A;  5L0K A;  4ZG9 A;  4UPK A;  4LRB A;  4MY4 A;  3WBH A;  4LR9 A;  1P49 A;  5K4P A;  3NKM A;  1ALH A;  1Y6V A;  5C66 A;  3BDH A;  4TN0 A;  1EQJ A;  4KAY A;  1KH5 A;  2W5W A;  1E1Z P;  4KM4 A;  1ELY A;  3UN2 A;  1FSU A;  3MK1 A;  1KH7 A;  3IDD A;  2GSN A;  4LRD A;  3BDG A;  1AJD A;  3TX0 A;  1SHQ A;  3NKN A;  3UO0 A;  4CYR A;  1ELZ A;  5AJ9 A;  1AJB A;  5GOV A;  3WAX A;  3SZY A;  3SZZ A;  4FDJ A;  5IJQ A;  3Q3Q A;  1AJA A;  1B8J A;  4CXU A;  5HRT A;  4UOR A;  2RH6 A;  3NVL A;  4CYS A;  4YR1 A;  4MHX A;  1EI6 A;  2GLQ A;  3M8Z A;  2X98 A;  1EW9 A;  4UPI A;  4UPH A;  1N2K A;  1ALJ A;  3A52 A;  2ANH A;  2D1G A;  1ALK A;  4GTX A;  2G9Y A;  1E2S P;  1HJK A;  2W5T A;  3DPC A;  4MIV A;  1AUK A;  4LQY A;  5IJS A;  1ANJ A;  1E3C P;  2GA3 A;  5LIA A;  3BDG B;  4UOO A;  1URA A;  3E2D A;  5TJ3 A;  3UN5 A;  3LXQ A;  3M7V A;  3IGY B;  4B56 A;  2XRG A;  4LRA A;  1URB A;  5KXA A;  4GTW A;  5LRN A;  3OT9 A;  1HQA A;  1ELX A;  3DYC A;  3WAW A;  3IGZ B;  4GTY A;  3NKQ A;  5L0B A;  4QAX A;  1Y7A A;  2W5S A;  3KD8 A;  1ZEF A;  3CMR A;  3UN3 A;  4ZG7 A;  3TWZ A;  2W5X A;  1KHL A;  1ZED A;  3T00 A;  2W5V A;  4NWJ A;  3M8Y A;  5EGH A;  5LQQ A;  4LRE A;  3NKO A;  5DLW A;  2W5Q A;  3NKR A;  2W8S A;  4LR7 A;  1KHJ A;  4LRF A;  3NKP A;  4GTZ A;  5INH A;  5DLT A;  1KH9 A;  4N7T A;  2XR9 A;  1EJJ A;  3T01 A;  2IUC A;  1AJC A;  1SHN A;  3MK2 A;  4ZG6 A;  1ED9 A;  5L0E A;  1ZEB A;  1O99 A;  4LR8 A;  4KAV A;  3WAY A;  3ED4 A;  4NWX A;  4UPL A;  1EW2 A;  1KHN A;  5GRR A;  1ED8 A;  4KJG A;  1ALI A;  3M8W A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3MK1A

Total Genus

Knots found

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations