3IGYB

Crystal structures of leishmania mexicana phosphoglycerate mutase at high cobalt concentrations
Total Genus 205
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
205
Knots found
sequence length
549
structure length
549
Chain Sequence
LLLKPHKDLPRRTVLIVVMDGLGIGPEDDYDAVHMASTPFMDAHRRDNRHFRCVRAHGTAVGLPTDADMGNSEVGHNALGAGRVALQGASLVDDAIKSGEIYTGEGYRYLHGAFSKEGSTLHLIGLLSDGGVHSRDNQIYSIIEHAVKDGAKRIRVHALYDGRDVPDGSSFRFTDELEAVLAKVRQNGCDAAIASGGGRMFVTMDRYDADWSIVERGWRAQVLGDARHFHSAKEAITTFREEDPKVTDQYYPPFIVVDEQDKPLGTIEDGDAVLCVNFRGDRVIEMTRAFEDEDFNKFDRVRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNIFACSETQKFGHVTYFWNGNRSGKIDEKHETFKEVPSDRVQFNEKPRMQSAAITEAAIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGVEAVDESLAKLKDAVDSVNGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTSHTLSPVPVFIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPEDYEPSLIYVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Isomerase
molecule keywords Cofactor-independent phosphoglycerate mutase
publication title Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
pubmed doi rcsb
source organism Leishmania mexicana
total genus 205
structure length 549
sequence length 549
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.1: Transferred entry: 5.4.2.11 and 5.4.2.12.
pdb deposition date 2009-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01676 Metalloenzyme Metalloenzyme superfamily
B PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3igyB01
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 3igyB02
1HQAA 3NVLA 3M8YA 1ANJA 3T01A 4CXKA 2ZKTA 3NKMA 2GSOA 1E3CP 1EW9A 1KH4A 2W5XA 3M8ZA 2GSUA 1HJKA 2GA3A 3MK1A 5IJQA 5L0EA 4TN0A 2W8DA 5DLVA 4MY4A 4UPIA 4ZG7A 1KHLA 5EGHA 5LIAA 4NWJA 4LRBA 3WAYA 4CXSA 4UPKA 1O99A 2W5RA 5LQQA 5L0BA 4UORA 1Y7AA 3NKRA 4UPHA 5L0KA 3ED4A 3UN3A 1AJCA 4GTXA 1SHQA 4CXUA 4NWXA 4UOOA 4LREA 4LR8A 4LRDA 3T02A 4LRAA 3IDDA 1ED8A 3TG0A 1E33P 1ELXA 1EW2A 5DLTA 3M7VA 4GTYA 2W5QA 5IJSA 3BDGA 1ZEDA 1P49A 3NKPA 3LXQA 5GOVA 1KH7A 2ANHA 3DYCA 5LRNA 1EQJA 5K4PA 2W8SA 4ZG9A 3UN2A 3NKQA 4FDIA 4KAYA 1O98A 1ELZA 3WAWA 3M8WA 4B56A 5EGEA 3UO0A 1FSUA 1URBA 4QAXA 2X98A 5DLWA 4CYSA 3BDGB 3KD8A 4KJGA 3IGZB 3TWZA 4ZG6A 3SZZA 3T00A 3UN5A 1ELYA 3CMRA 3A52A 1N2KA 1KHNA 3NKNA 2XR9A 1EW8A 3Q3QA 3TX0A 4LR7A 5C66A 2IUCA 1HDHA 1ZEBA 3BDHA 4LRFA 5HRTA 1ALKA 1KH5A 3WAXA 1ED9A 2XRGA 1Y6VA 4FDJA 5TJ3A 4GTWA 2W5WA 3WAVA 3NKOA 1ANIA 3OT9A 5AJ9A 2RH6A 2GSNA 1E1ZP 4MHXA 2W5TA 1SHNA 2D1GA 2QZUA 5GRRA 1KHKA 1N2LA 2GLQA 2IUCB 4LR2A 2IFYA 1E2SP 1AJAA 3B5QA 1AJDA 4KJDA 1AUKA 4LQYA 3WBHA 4UPLA 4ZGAA 2W5VA 4MIVA 1KHJA 5KXAA 4N7TA 1URAA 4GTZA 1ALHA 2W5SA 1ALIA 3E2DA 1B8JA 3SZYA 4YR1A 4CYRA 2VQRA 1AJBA 1EI6A 3DPCA 2G9YA 1K7HA 3MK2A 3MK0A 1KH9A 4UOPA 5INHA 3UNYA 4LRCA 4KM4A 1EJJA 4KAVA 3BDFA 1ALJA 4LR9A 5LRMA 3IGYB 1ZEFA
chains in the Genus database with same CATH superfamily
1HQAA 3NVLA 3M8YA 1ANJA 3T01A 4CXKA 2ZKTA 3NKMA 2GSOA 1E3CP 1EW9A 1KH4A 2W5XA 3M8ZA 2GSUA 1HJKA 2GA3A 3MK1A 5IJQA 5L0EA 4TN0A 2W8DA 5DLVA 4MY4A 4UPIA 4ZG7A 1KHLA 5EGHA 5LIAA 4NWJA 4LRBA 3WAYA 4CXSA 4UPKA 1O99A 2W5RA 5LQQA 5L0BA 4UORA 1Y7AA 3NKRA 4UPHA 5L0KA 3ED4A 3UN3A 1AJCA 4GTXA 1SHQA 4CXUA 4NWXA 4UOOA 4LREA 4LR8A 4LRDA 3T02A 4LRAA 3IDDA 1ED8A 3TG0A 1E33P 1ELXA 1EW2A 5DLTA 3M7VA 4GTYA 2W5QA 5IJSA 3BDGA 1ZEDA 1P49A 3NKPA 3LXQA 5GOVA 1KH7A 2ANHA 3DYCA 5LRNA 1EQJA 5K4PA 2W8SA 4ZG9A 3UN2A 3NKQA 4FDIA 4KAYA 1O98A 1ELZA 3WAWA 3M8WA 4B56A 5EGEA 3UO0A 1FSUA 1URBA 4QAXA 2X98A 5DLWA 4CYSA 3BDGB 3KD8A 4KJGA 3IGZB 3TWZA 4ZG6A 3SZZA 3T00A 3UN5A 1ELYA 3CMRA 3A52A 1N2KA 1KHNA 3NKNA 2XR9A 1EW8A 3Q3QA 3TX0A 4LR7A 5C66A 2IUCA 1HDHA 1ZEBA 3BDHA 4LRFA 5HRTA 1ALKA 1KH5A 3WAXA 1ED9A 2XRGA 1Y6VA 4FDJA 5TJ3A 4GTWA 2W5WA 3WAVA 3NKOA 1ANIA 3OT9A 5AJ9A 2RH6A 2GSNA 1E1ZP 4MHXA 2W5TA 1SHNA 2D1GA 2QZUA 5GRRA 1KHKA 1N2LA 2GLQA 2IUCB 4LR2A 2IFYA 1E2SP 1AJAA 3B5QA 1AJDA 4KJDA 1AUKA 4LQYA 3WBHA 4UPLA 4ZGAA 2W5VA 4MIVA 1KHJA 5KXAA 4N7TA 1URAA 4GTZA 1ALHA 2W5SA 1ALIA 3E2DA 1B8JA 3SZYA 4YR1A 4CYRA 2VQRA 1AJBA 1EI6A 3DPCA 2G9YA 1K7HA 3MK2A 3MK0A 1KH9A 4UOPA 5INHA 3UNYA 4LRCA 4KM4A 1EJJA 4KAVA 3BDFA 1ALJA 4LR9A 5LRMA 3IGYB 1ZEFA
chains in the Genus database with same CATH topology
1HQAA 3NVLA 3M8YA 1ANJA 3T01A 4CXKA 2ZKTA 3NKMA 2GSOA 1E3CP 1EW9A 1KH4A 2W5XA 3M8ZA 2GSUA 1HJKA 2GA3A 3MK1A 5IJQA 5L0EA 4TN0A 2W8DA 5DLVA 4MY4A 4UPIA 4ZG7A 1KHLA 5EGHA 5LIAA 4NWJA 4LRBA 3WAYA 4CXSA 4UPKA 1O99A 2W5RA 5LQQA 5L0BA 4UORA 1Y7AA 3NKRA 4UPHA 5L0KA 3ED4A 3UN3A 1AJCA 4GTXA 1SHQA 4CXUA 4NWXA 4UOOA 4LREA 4LR8A 4LRDA 3T02A 4LRAA 3IDDA 1ED8A 3TG0A 1E33P 1ELXA 1EW2A 5DLTA 3M7VA 4GTYA 2W5QA 5IJSA 3BDGA 1ZEDA 1P49A 3NKPA 3LXQA 5GOVA 1KH7A 2ANHA 3DYCA 5LRNA 1EQJA 5K4PA 2W8SA 4ZG9A 3UN2A 3NKQA 4FDIA 4KAYA 1O98A 1ELZA 3WAWA 3M8WA 4B56A 5EGEA 3UO0A 1FSUA 1URBA 4QAXA 2X98A 5DLWA 4CYSA 3BDGB 3KD8A 4KJGA 3IGZB 3TWZA 4ZG6A 3SZZA 3T00A 3UN5A 1ELYA 3CMRA 3A52A 1N2KA 1KHNA 3NKNA 2XR9A 1EW8A 3Q3QA 3TX0A 4LR7A 5C66A 2IUCA 1HDHA 1ZEBA 3BDHA 4LRFA 5HRTA 1ALKA 1KH5A 3WAXA 1ED9A 2XRGA 1Y6VA 4FDJA 5TJ3A 4GTWA 2W5WA 3WAVA 3NKOA 1ANIA 3OT9A 5AJ9A 2RH6A 2GSNA 1E1ZP 4MHXA 2W5TA 1SHNA 2D1GA 2QZUA 5GRRA 1KHKA 1N2LA 2GLQA 2IUCB 4LR2A 2IFYA 1E2SP 1AJAA 3B5QA 1AJDA 4KJDA 1AUKA 4LQYA 3WBHA 4UPLA 4ZGAA 2W5VA 4MIVA 1KHJA 5KXAA 4N7TA 1URAA 4GTZA 1ALHA 2W5SA 1ALIA 3E2DA 1B8JA 3SZYA 4YR1A 4CYRA 2VQRA 1AJBA 1EI6A 3DPCA 2G9YA 1K7HA 3MK2A 3MK0A 1KH9A 4UOPA 5INHA 3UNYA 4LRCA 4KM4A 1EJJA 4KAVA 3BDFA 1ALJA 4LR9A 5LRMA 3IGYB 1ZEFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HQA A;  3NVL A;  3M8Y A;  1ANJ A;  3T01 A;  4CXK A;  2ZKT A;  3NKM A;  2GSO A;  1E3C P;  1EW9 A;  1KH4 A;  2W5X A;  3M8Z A;  2GSU A;  1HJK A;  2GA3 A;  3MK1 A;  5IJQ A;  5L0E A;  4TN0 A;  2W8D A;  5DLV A;  4MY4 A;  4UPI A;  4ZG7 A;  1KHL A;  5EGH A;  5LIA A;  4NWJ A;  4LRB A;  3WAY A;  4CXS A;  4UPK A;  1O99 A;  2W5R A;  5LQQ A;  5L0B A;  4UOR A;  1Y7A A;  3NKR A;  4UPH A;  5L0K A;  3ED4 A;  3UN3 A;  1AJC A;  4GTX A;  1SHQ A;  4CXU A;  4NWX A;  4UOO A;  4LRE A;  4LR8 A;  4LRD A;  3T02 A;  4LRA A;  3IDD A;  1ED8 A;  3TG0 A;  1E33 P;  1ELX A;  1EW2 A;  5DLT A;  3M7V A;  4GTY A;  2W5Q A;  5IJS A;  3BDG A;  1ZED A;  1P49 A;  3NKP A;  3LXQ A;  5GOV A;  1KH7 A;  2ANH A;  3DYC A;  5LRN A;  1EQJ A;  5K4P A;  2W8S A;  4ZG9 A;  3UN2 A;  3NKQ A;  4FDI A;  4KAY A;  1O98 A;  1ELZ A;  3WAW A;  3M8W A;  4B56 A;  5EGE A;  3UO0 A;  1FSU A;  1URB A;  4QAX A;  2X98 A;  5DLW A;  4CYS A;  3BDG B;  3KD8 A;  4KJG A;  3IGZ B;  3TWZ A;  4ZG6 A;  3SZZ A;  3T00 A;  3UN5 A;  1ELY A;  3CMR A;  3A52 A;  1N2K A;  1KHN A;  3NKN A;  2XR9 A;  1EW8 A;  3Q3Q A;  3TX0 A;  4LR7 A;  5C66 A;  2IUC A;  1HDH A;  1ZEB A;  3BDH A;  4LRF A;  5HRT A;  1ALK A;  1KH5 A;  3WAX A;  1ED9 A;  2XRG A;  1Y6V A;  4FDJ A;  5TJ3 A;  4GTW A;  2W5W A;  3WAV A;  3NKO A;  1ANI A;  3OT9 A;  5AJ9 A;  2RH6 A;  2GSN A;  1E1Z P;  4MHX A;  2W5T A;  1SHN A;  2D1G A;  2QZU A;  5GRR A;  1KHK A;  1N2L A;  2GLQ A;  2IUC B;  4LR2 A;  2IFY A;  1E2S P;  1AJA A;  3B5Q A;  1AJD A;  4KJD A;  1AUK A;  4LQY A;  3WBH A;  4UPL A;  4ZGA A;  2W5V A;  4MIV A;  1KHJ A;  5KXA A;  4N7T A;  1URA A;  4GTZ A;  1ALH A;  2W5S A;  1ALI A;  3E2D A;  1B8J A;  3SZY A;  4YR1 A;  4CYR A;  2VQR A;  1AJB A;  1EI6 A;  3DPC A;  2G9Y A;  1K7H A;  3MK2 A;  3MK0 A;  1KH9 A;  4UOP A;  5INH A;  3UNY A;  4LRC A;  4KM4 A;  1EJJ A;  4KAV A;  3BDF A;  1ALJ A;  4LR9 A;  5LRM A;  3IGY B;  1ZEF A; 
#chains in the Genus database with same CATH topology
 1HQA A;  3NVL A;  3M8Y A;  1ANJ A;  3T01 A;  4CXK A;  2ZKT A;  3NKM A;  2GSO A;  1E3C P;  1EW9 A;  1KH4 A;  2W5X A;  3M8Z A;  2GSU A;  1HJK A;  2GA3 A;  3MK1 A;  5IJQ A;  5L0E A;  4TN0 A;  2W8D A;  5DLV A;  4MY4 A;  4UPI A;  4ZG7 A;  1KHL A;  5EGH A;  5LIA A;  4NWJ A;  4LRB A;  3WAY A;  4CXS A;  4UPK A;  1O99 A;  2W5R A;  5LQQ A;  5L0B A;  4UOR A;  1Y7A A;  3NKR A;  4UPH A;  5L0K A;  3ED4 A;  3UN3 A;  1AJC A;  4GTX A;  1SHQ A;  4CXU A;  4NWX A;  4UOO A;  4LRE A;  4LR8 A;  4LRD A;  3T02 A;  4LRA A;  3IDD A;  1ED8 A;  3TG0 A;  1E33 P;  1ELX A;  1EW2 A;  5DLT A;  3M7V A;  4GTY A;  2W5Q A;  5IJS A;  3BDG A;  1ZED A;  1P49 A;  3NKP A;  3LXQ A;  5GOV A;  1KH7 A;  2ANH A;  3DYC A;  5LRN A;  1EQJ A;  5K4P A;  2W8S A;  4ZG9 A;  3UN2 A;  3NKQ A;  4FDI A;  4KAY A;  1O98 A;  1ELZ A;  3WAW A;  3M8W A;  4B56 A;  5EGE A;  3UO0 A;  1FSU A;  1URB A;  4QAX A;  2X98 A;  5DLW A;  4CYS A;  3BDG B;  3KD8 A;  4KJG A;  3IGZ B;  3TWZ A;  4ZG6 A;  3SZZ A;  3T00 A;  3UN5 A;  1ELY A;  3CMR A;  3A52 A;  1N2K A;  1KHN A;  3NKN A;  2XR9 A;  1EW8 A;  3Q3Q A;  3TX0 A;  4LR7 A;  5C66 A;  2IUC A;  1HDH A;  1ZEB A;  3BDH A;  4LRF A;  5HRT A;  1ALK A;  1KH5 A;  3WAX A;  1ED9 A;  2XRG A;  1Y6V A;  4FDJ A;  5TJ3 A;  4GTW A;  2W5W A;  3WAV A;  3NKO A;  1ANI A;  3OT9 A;  5AJ9 A;  2RH6 A;  2GSN A;  1E1Z P;  4MHX A;  2W5T A;  1SHN A;  2D1G A;  2QZU A;  5GRR A;  1KHK A;  1N2L A;  2GLQ A;  2IUC B;  4LR2 A;  2IFY A;  1E2S P;  1AJA A;  3B5Q A;  1AJD A;  4KJD A;  1AUK A;  4LQY A;  3WBH A;  4UPL A;  4ZGA A;  2W5V A;  4MIV A;  1KHJ A;  5KXA A;  4N7T A;  1URA A;  4GTZ A;  1ALH A;  2W5S A;  1ALI A;  3E2D A;  1B8J A;  3SZY A;  4YR1 A;  4CYR A;  2VQR A;  1AJB A;  1EI6 A;  3DPC A;  2G9Y A;  1K7H A;  3MK2 A;  3MK0 A;  1KH9 A;  4UOP A;  5INH A;  3UNY A;  4LRC A;  4KM4 A;  1EJJ A;  4KAV A;  3BDF A;  1ALJ A;  4LR9 A;  5LRM A;  3IGY B;  1ZEF A; 
#chains in the Genus database with same CATH homology
 1HQA A;  3NVL A;  3M8Y A;  1ANJ A;  3T01 A;  4CXK A;  2ZKT A;  3NKM A;  2GSO A;  1E3C P;  1EW9 A;  1KH4 A;  2W5X A;  3M8Z A;  2GSU A;  1HJK A;  2GA3 A;  3MK1 A;  5IJQ A;  5L0E A;  4TN0 A;  2W8D A;  5DLV A;  4MY4 A;  4UPI A;  4ZG7 A;  1KHL A;  5EGH A;  5LIA A;  4NWJ A;  4LRB A;  3WAY A;  4CXS A;  4UPK A;  1O99 A;  2W5R A;  5LQQ A;  5L0B A;  4UOR A;  1Y7A A;  3NKR A;  4UPH A;  5L0K A;  3ED4 A;  3UN3 A;  1AJC A;  4GTX A;  1SHQ A;  4CXU A;  4NWX A;  4UOO A;  4LRE A;  4LR8 A;  4LRD A;  3T02 A;  4LRA A;  3IDD A;  1ED8 A;  3TG0 A;  1E33 P;  1ELX A;  1EW2 A;  5DLT A;  3M7V A;  4GTY A;  2W5Q A;  5IJS A;  3BDG A;  1ZED A;  1P49 A;  3NKP A;  3LXQ A;  5GOV A;  1KH7 A;  2ANH A;  3DYC A;  5LRN A;  1EQJ A;  5K4P A;  2W8S A;  4ZG9 A;  3UN2 A;  3NKQ A;  4FDI A;  4KAY A;  1O98 A;  1ELZ A;  3WAW A;  3M8W A;  4B56 A;  5EGE A;  3UO0 A;  1FSU A;  1URB A;  4QAX A;  2X98 A;  5DLW A;  4CYS A;  3BDG B;  3KD8 A;  4KJG A;  3IGZ B;  3TWZ A;  4ZG6 A;  3SZZ A;  3T00 A;  3UN5 A;  1ELY A;  3CMR A;  3A52 A;  1N2K A;  1KHN A;  3NKN A;  2XR9 A;  1EW8 A;  3Q3Q A;  3TX0 A;  4LR7 A;  5C66 A;  2IUC A;  1HDH A;  1ZEB A;  3BDH A;  4LRF A;  5HRT A;  1ALK A;  1KH5 A;  3WAX A;  1ED9 A;  2XRG A;  1Y6V A;  4FDJ A;  5TJ3 A;  4GTW A;  2W5W A;  3WAV A;  3NKO A;  1ANI A;  3OT9 A;  5AJ9 A;  2RH6 A;  2GSN A;  1E1Z P;  4MHX A;  2W5T A;  1SHN A;  2D1G A;  2QZU A;  5GRR A;  1KHK A;  1N2L A;  2GLQ A;  2IUC B;  4LR2 A;  2IFY A;  1E2S P;  1AJA A;  3B5Q A;  1AJD A;  4KJD A;  1AUK A;  4LQY A;  3WBH A;  4UPL A;  4ZGA A;  2W5V A;  4MIV A;  1KHJ A;  5KXA A;  4N7T A;  1URA A;  4GTZ A;  1ALH A;  2W5S A;  1ALI A;  3E2D A;  1B8J A;  3SZY A;  4YR1 A;  4CYR A;  2VQR A;  1AJB A;  1EI6 A;  3DPC A;  2G9Y A;  1K7H A;  3MK2 A;  3MK0 A;  1KH9 A;  4UOP A;  5INH A;  3UNY A;  4LRC A;  4KM4 A;  1EJJ A;  4KAV A;  3BDF A;  1ALJ A;  4LR9 A;  5LRM A;  3IGY B;  1ZEF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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