3MK0A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 178
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk0A00
3E2DA 1ALHA 3NKPA 4QAXA 3M8YA 5DLTA 5GRRA 3MK1A 5IJQA 1AJAA 3IGYB 4UPLA 1E1ZP 5L0BA 3BDGB 4MIVA 5L0KA 1K7HA 2IFYA 2XR9A 1KHJA 3NKOA 4KAVA 4LR7A 2W5SA 3WAYA 3KD8A 3OT9A 2W5WA 2XRGA 3WAWA 4FDIA 4CXSA 3NVLA 3BDFA 5C66A 3DPCA 4KM4A 4GTZA 2GSUA 1AJCA 2IUCA 4LQYA 5LIAA 3ED4A 2W5TA 1P49A 2W8SA 5K4PA 2GLQA 1E33P 4KAYA 4KJGA 1EQJA 4LR9A 3NKMA 3CMRA 1ANJA 4LRCA 5IJSA 1N2KA 4ZG9A 4NWJA 3SZYA 4LRFA 1SHNA 3M7VA 1ED8A 4LRAA 3TX0A 4TN0A 5AJ9A 3IDDA 1EW2A 3WBHA 1KHKA 5EGHA 2W5QA 1URBA 2X98A 3A52A 4UOOA 3BDHA 3DYCA 1EI6A 1ZEBA 3T01A 4YR1A 1HDHA 1ELZA 5KXAA 4NWXA 1KHLA 1EJJA 2ZKTA 4N7TA 2QZUA 3M8WA 2RH6A 2GA3A 3BDGA 1ALKA 4KJDA 3B5QA 4UORA 1KH7A 3Q3QA 3TWZA 1ALJA 3MK2A 4CXUA 4LRBA 2ANHA 1E2SP 1FSUA 4LRDA 4UPKA 4CYSA 2GSOA 4LR2A 2W8DA 2W5RA 4GTXA 1KH4A 2VQRA 3WAVA 4MHXA 2IUCB 3M8ZA 3NKQA 3T02A 1AJBA 4CXKA 4FDJA 1KH5A 1ZEFA 4LREA 1ELXA 5EGEA 4GTYA 3UN3A 1KH9A 5DLVA 3UO0A 3TG0A 4MY4A 5HRTA 1ELYA 1AJDA 1SHQA 1ZEDA 3LXQA 4UOPA 1O98A 4ZGAA 5INHA 1URAA 3MK0A 1EW9A 5TJ3A 1B8JA 1EW8A 1AUKA 4ZG7A 4UPHA 3SZZA 3NKRA 5LRNA 4LR8A 4ZG6A 5L0EA 1HJKA 2G9YA 5LQQA 5DLWA 3UN2A 1N2LA 3UN5A 2GSNA 2D1GA 4GTWA 4UPIA 3IGZB 1ED9A 5GOVA 3UNYA 3NKNA 1HQAA 1Y6VA 3WAXA 2W5XA 1ALIA 1E3CP 5LRMA 4B56A 4CYRA 1Y7AA 2W5VA 1O99A 3T00A 1KHNA 1ANIA
chains in the Genus database with same CATH superfamily
3E2DA 1ALHA 3NKPA 4QAXA 3M8YA 5DLTA 5GRRA 3MK1A 5IJQA 1AJAA 3IGYB 4UPLA 1E1ZP 5L0BA 3BDGB 4MIVA 5L0KA 1K7HA 2IFYA 2XR9A 1KHJA 3NKOA 4KAVA 4LR7A 2W5SA 3WAYA 3KD8A 3OT9A 2W5WA 2XRGA 3WAWA 4FDIA 4CXSA 3NVLA 3BDFA 5C66A 3DPCA 4KM4A 4GTZA 2GSUA 1AJCA 2IUCA 4LQYA 5LIAA 3ED4A 2W5TA 1P49A 2W8SA 5K4PA 2GLQA 1E33P 4KAYA 4KJGA 1EQJA 4LR9A 3NKMA 3CMRA 1ANJA 4LRCA 5IJSA 1N2KA 4ZG9A 4NWJA 3SZYA 4LRFA 1SHNA 3M7VA 1ED8A 4LRAA 3TX0A 4TN0A 5AJ9A 3IDDA 1EW2A 3WBHA 1KHKA 5EGHA 2W5QA 1URBA 2X98A 3A52A 4UOOA 3BDHA 3DYCA 1EI6A 1ZEBA 3T01A 4YR1A 1HDHA 1ELZA 5KXAA 4NWXA 1KHLA 1EJJA 2ZKTA 4N7TA 2QZUA 3M8WA 2RH6A 2GA3A 3BDGA 1ALKA 4KJDA 3B5QA 4UORA 1KH7A 3Q3QA 3TWZA 1ALJA 3MK2A 4CXUA 4LRBA 2ANHA 1E2SP 1FSUA 4LRDA 4UPKA 4CYSA 2GSOA 4LR2A 2W8DA 2W5RA 4GTXA 1KH4A 2VQRA 3WAVA 4MHXA 2IUCB 3M8ZA 3NKQA 3T02A 1AJBA 4CXKA 4FDJA 1KH5A 1ZEFA 4LREA 1ELXA 5EGEA 4GTYA 3UN3A 1KH9A 5DLVA 3UO0A 3TG0A 4MY4A 5HRTA 1ELYA 1AJDA 1SHQA 1ZEDA 3LXQA 4UOPA 1O98A 4ZGAA 5INHA 1URAA 3MK0A 1EW9A 5TJ3A 1B8JA 1EW8A 1AUKA 4ZG7A 4UPHA 3SZZA 3NKRA 5LRNA 4LR8A 4ZG6A 5L0EA 1HJKA 2G9YA 5LQQA 5DLWA 3UN2A 1N2LA 3UN5A 2GSNA 2D1GA 4GTWA 4UPIA 3IGZB 1ED9A 5GOVA 3UNYA 3NKNA 1HQAA 1Y6VA 3WAXA 2W5XA 1ALIA 1E3CP 5LRMA 4B56A 4CYRA 1Y7AA 2W5VA 1O99A 3T00A 1KHNA 1ANIA
chains in the Genus database with same CATH topology
3E2DA 1ALHA 3NKPA 4QAXA 3M8YA 5DLTA 5GRRA 3MK1A 5IJQA 1AJAA 3IGYB 4UPLA 1E1ZP 5L0BA 3BDGB 4MIVA 5L0KA 1K7HA 2IFYA 2XR9A 1KHJA 3NKOA 4KAVA 4LR7A 2W5SA 3WAYA 3KD8A 3OT9A 2W5WA 2XRGA 3WAWA 4FDIA 4CXSA 3NVLA 3BDFA 5C66A 3DPCA 4KM4A 4GTZA 2GSUA 1AJCA 2IUCA 4LQYA 5LIAA 3ED4A 2W5TA 1P49A 2W8SA 5K4PA 2GLQA 1E33P 4KAYA 4KJGA 1EQJA 4LR9A 3NKMA 3CMRA 1ANJA 4LRCA 5IJSA 1N2KA 4ZG9A 4NWJA 3SZYA 4LRFA 1SHNA 3M7VA 1ED8A 4LRAA 3TX0A 4TN0A 5AJ9A 3IDDA 1EW2A 3WBHA 1KHKA 5EGHA 2W5QA 1URBA 2X98A 3A52A 4UOOA 3BDHA 3DYCA 1EI6A 1ZEBA 3T01A 4YR1A 1HDHA 1ELZA 5KXAA 4NWXA 1KHLA 1EJJA 2ZKTA 4N7TA 2QZUA 3M8WA 2RH6A 2GA3A 3BDGA 1ALKA 4KJDA 3B5QA 4UORA 1KH7A 3Q3QA 3TWZA 1ALJA 3MK2A 4CXUA 4LRBA 2ANHA 1E2SP 1FSUA 4LRDA 4UPKA 4CYSA 2GSOA 4LR2A 2W8DA 2W5RA 4GTXA 1KH4A 2VQRA 3WAVA 4MHXA 2IUCB 3M8ZA 3NKQA 3T02A 1AJBA 4CXKA 4FDJA 1KH5A 1ZEFA 4LREA 1ELXA 5EGEA 4GTYA 3UN3A 1KH9A 5DLVA 3UO0A 3TG0A 4MY4A 5HRTA 1ELYA 1AJDA 1SHQA 1ZEDA 3LXQA 4UOPA 1O98A 4ZGAA 5INHA 1URAA 3MK0A 1EW9A 5TJ3A 1B8JA 1EW8A 1AUKA 4ZG7A 4UPHA 3SZZA 3NKRA 5LRNA 4LR8A 4ZG6A 5L0EA 1HJKA 2G9YA 5LQQA 5DLWA 3UN2A 1N2LA 3UN5A 2GSNA 2D1GA 4GTWA 4UPIA 3IGZB 1ED9A 5GOVA 3UNYA 3NKNA 1HQAA 1Y6VA 3WAXA 2W5XA 1ALIA 1E3CP 5LRMA 4B56A 4CYRA 1Y7AA 2W5VA 1O99A 3T00A 1KHNA 1ANIA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3E2D A;  1ALH A;  3NKP A;  4QAX A;  3M8Y A;  5DLT A;  5GRR A;  3MK1 A;  5IJQ A;  1AJA A;  3IGY B;  4UPL A;  1E1Z P;  5L0B A;  3BDG B;  4MIV A;  5L0K A;  1K7H A;  2IFY A;  2XR9 A;  1KHJ A;  3NKO A;  4KAV A;  4LR7 A;  2W5S A;  3WAY A;  3KD8 A;  3OT9 A;  2W5W A;  2XRG A;  3WAW A;  4FDI A;  4CXS A;  3NVL A;  3BDF A;  5C66 A;  3DPC A;  4KM4 A;  4GTZ A;  2GSU A;  1AJC A;  2IUC A;  4LQY A;  5LIA A;  3ED4 A;  2W5T A;  1P49 A;  2W8S A;  5K4P A;  2GLQ A;  1E33 P;  4KAY A;  4KJG A;  1EQJ A;  4LR9 A;  3NKM A;  3CMR A;  1ANJ A;  4LRC A;  5IJS A;  1N2K A;  4ZG9 A;  4NWJ A;  3SZY A;  4LRF A;  1SHN A;  3M7V A;  1ED8 A;  4LRA A;  3TX0 A;  4TN0 A;  5AJ9 A;  3IDD A;  1EW2 A;  3WBH A;  1KHK A;  5EGH A;  2W5Q A;  1URB A;  2X98 A;  3A52 A;  4UOO A;  3BDH A;  3DYC A;  1EI6 A;  1ZEB A;  3T01 A;  4YR1 A;  1HDH A;  1ELZ A;  5KXA A;  4NWX A;  1KHL A;  1EJJ A;  2ZKT A;  4N7T A;  2QZU A;  3M8W A;  2RH6 A;  2GA3 A;  3BDG A;  1ALK A;  4KJD A;  3B5Q A;  4UOR A;  1KH7 A;  3Q3Q A;  3TWZ A;  1ALJ A;  3MK2 A;  4CXU A;  4LRB A;  2ANH A;  1E2S P;  1FSU A;  4LRD A;  4UPK A;  4CYS A;  2GSO A;  4LR2 A;  2W8D A;  2W5R A;  4GTX A;  1KH4 A;  2VQR A;  3WAV A;  4MHX A;  2IUC B;  3M8Z A;  3NKQ A;  3T02 A;  1AJB A;  4CXK A;  4FDJ A;  1KH5 A;  1ZEF A;  4LRE A;  1ELX A;  5EGE A;  4GTY A;  3UN3 A;  1KH9 A;  5DLV A;  3UO0 A;  3TG0 A;  4MY4 A;  5HRT A;  1ELY A;  1AJD A;  1SHQ A;  1ZED A;  3LXQ A;  4UOP A;  1O98 A;  4ZGA A;  5INH A;  1URA A;  3MK0 A;  1EW9 A;  5TJ3 A;  1B8J A;  1EW8 A;  1AUK A;  4ZG7 A;  4UPH A;  3SZZ A;  3NKR A;  5LRN A;  4LR8 A;  4ZG6 A;  5L0E A;  1HJK A;  2G9Y A;  5LQQ A;  5DLW A;  3UN2 A;  1N2L A;  3UN5 A;  2GSN A;  2D1G A;  4GTW A;  4UPI A;  3IGZ B;  1ED9 A;  5GOV A;  3UNY A;  3NKN A;  1HQA A;  1Y6V A;  3WAX A;  2W5X A;  1ALI A;  1E3C P;  5LRM A;  4B56 A;  4CYR A;  1Y7A A;  2W5V A;  1O99 A;  3T00 A;  1KHN A;  1ANI A; 
#chains in the Genus database with same CATH topology
 3E2D A;  1ALH A;  3NKP A;  4QAX A;  3M8Y A;  5DLT A;  5GRR A;  3MK1 A;  5IJQ A;  1AJA A;  3IGY B;  4UPL A;  1E1Z P;  5L0B A;  3BDG B;  4MIV A;  5L0K A;  1K7H A;  2IFY A;  2XR9 A;  1KHJ A;  3NKO A;  4KAV A;  4LR7 A;  2W5S A;  3WAY A;  3KD8 A;  3OT9 A;  2W5W A;  2XRG A;  3WAW A;  4FDI A;  4CXS A;  3NVL A;  3BDF A;  5C66 A;  3DPC A;  4KM4 A;  4GTZ A;  2GSU A;  1AJC A;  2IUC A;  4LQY A;  5LIA A;  3ED4 A;  2W5T A;  1P49 A;  2W8S A;  5K4P A;  2GLQ A;  1E33 P;  4KAY A;  4KJG A;  1EQJ A;  4LR9 A;  3NKM A;  3CMR A;  1ANJ A;  4LRC A;  5IJS A;  1N2K A;  4ZG9 A;  4NWJ A;  3SZY A;  4LRF A;  1SHN A;  3M7V A;  1ED8 A;  4LRA A;  3TX0 A;  4TN0 A;  5AJ9 A;  3IDD A;  1EW2 A;  3WBH A;  1KHK A;  5EGH A;  2W5Q A;  1URB A;  2X98 A;  3A52 A;  4UOO A;  3BDH A;  3DYC A;  1EI6 A;  1ZEB A;  3T01 A;  4YR1 A;  1HDH A;  1ELZ A;  5KXA A;  4NWX A;  1KHL A;  1EJJ A;  2ZKT A;  4N7T A;  2QZU A;  3M8W A;  2RH6 A;  2GA3 A;  3BDG A;  1ALK A;  4KJD A;  3B5Q A;  4UOR A;  1KH7 A;  3Q3Q A;  3TWZ A;  1ALJ A;  3MK2 A;  4CXU A;  4LRB A;  2ANH A;  1E2S P;  1FSU A;  4LRD A;  4UPK A;  4CYS A;  2GSO A;  4LR2 A;  2W8D A;  2W5R A;  4GTX A;  1KH4 A;  2VQR A;  3WAV A;  4MHX A;  2IUC B;  3M8Z A;  3NKQ A;  3T02 A;  1AJB A;  4CXK A;  4FDJ A;  1KH5 A;  1ZEF A;  4LRE A;  1ELX A;  5EGE A;  4GTY A;  3UN3 A;  1KH9 A;  5DLV A;  3UO0 A;  3TG0 A;  4MY4 A;  5HRT A;  1ELY A;  1AJD A;  1SHQ A;  1ZED A;  3LXQ A;  4UOP A;  1O98 A;  4ZGA A;  5INH A;  1URA A;  3MK0 A;  1EW9 A;  5TJ3 A;  1B8J A;  1EW8 A;  1AUK A;  4ZG7 A;  4UPH A;  3SZZ A;  3NKR A;  5LRN A;  4LR8 A;  4ZG6 A;  5L0E A;  1HJK A;  2G9Y A;  5LQQ A;  5DLW A;  3UN2 A;  1N2L A;  3UN5 A;  2GSN A;  2D1G A;  4GTW A;  4UPI A;  3IGZ B;  1ED9 A;  5GOV A;  3UNY A;  3NKN A;  1HQA A;  1Y6V A;  3WAX A;  2W5X A;  1ALI A;  1E3C P;  5LRM A;  4B56 A;  4CYR A;  1Y7A A;  2W5V A;  1O99 A;  3T00 A;  1KHN A;  1ANI A; 
#chains in the Genus database with same CATH homology
 3E2D A;  1ALH A;  3NKP A;  4QAX A;  3M8Y A;  5DLT A;  5GRR A;  3MK1 A;  5IJQ A;  1AJA A;  3IGY B;  4UPL A;  1E1Z P;  5L0B A;  3BDG B;  4MIV A;  5L0K A;  1K7H A;  2IFY A;  2XR9 A;  1KHJ A;  3NKO A;  4KAV A;  4LR7 A;  2W5S A;  3WAY A;  3KD8 A;  3OT9 A;  2W5W A;  2XRG A;  3WAW A;  4FDI A;  4CXS A;  3NVL A;  3BDF A;  5C66 A;  3DPC A;  4KM4 A;  4GTZ A;  2GSU A;  1AJC A;  2IUC A;  4LQY A;  5LIA A;  3ED4 A;  2W5T A;  1P49 A;  2W8S A;  5K4P A;  2GLQ A;  1E33 P;  4KAY A;  4KJG A;  1EQJ A;  4LR9 A;  3NKM A;  3CMR A;  1ANJ A;  4LRC A;  5IJS A;  1N2K A;  4ZG9 A;  4NWJ A;  3SZY A;  4LRF A;  1SHN A;  3M7V A;  1ED8 A;  4LRA A;  3TX0 A;  4TN0 A;  5AJ9 A;  3IDD A;  1EW2 A;  3WBH A;  1KHK A;  5EGH A;  2W5Q A;  1URB A;  2X98 A;  3A52 A;  4UOO A;  3BDH A;  3DYC A;  1EI6 A;  1ZEB A;  3T01 A;  4YR1 A;  1HDH A;  1ELZ A;  5KXA A;  4NWX A;  1KHL A;  1EJJ A;  2ZKT A;  4N7T A;  2QZU A;  3M8W A;  2RH6 A;  2GA3 A;  3BDG A;  1ALK A;  4KJD A;  3B5Q A;  4UOR A;  1KH7 A;  3Q3Q A;  3TWZ A;  1ALJ A;  3MK2 A;  4CXU A;  4LRB A;  2ANH A;  1E2S P;  1FSU A;  4LRD A;  4UPK A;  4CYS A;  2GSO A;  4LR2 A;  2W8D A;  2W5R A;  4GTX A;  1KH4 A;  2VQR A;  3WAV A;  4MHX A;  2IUC B;  3M8Z A;  3NKQ A;  3T02 A;  1AJB A;  4CXK A;  4FDJ A;  1KH5 A;  1ZEF A;  4LRE A;  1ELX A;  5EGE A;  4GTY A;  3UN3 A;  1KH9 A;  5DLV A;  3UO0 A;  3TG0 A;  4MY4 A;  5HRT A;  1ELY A;  1AJD A;  1SHQ A;  1ZED A;  3LXQ A;  4UOP A;  1O98 A;  4ZGA A;  5INH A;  1URA A;  3MK0 A;  1EW9 A;  5TJ3 A;  1B8J A;  1EW8 A;  1AUK A;  4ZG7 A;  4UPH A;  3SZZ A;  3NKR A;  5LRN A;  4LR8 A;  4ZG6 A;  5L0E A;  1HJK A;  2G9Y A;  5LQQ A;  5DLW A;  3UN2 A;  1N2L A;  3UN5 A;  2GSN A;  2D1G A;  4GTW A;  4UPI A;  3IGZ B;  1ED9 A;  5GOV A;  3UNY A;  3NKN A;  1HQA A;  1Y6V A;  3WAX A;  2W5X A;  1ALI A;  1E3C P;  5LRM A;  4B56 A;  4CYR A;  1Y7A A;  2W5V A;  1O99 A;  3T00 A;  1KHN A;  1ANI A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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