3MK1A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
Knots found
sequence length
481
structure length
480
Chain Sequence
b'IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
total genus 180
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk1A00
1Y6VA 3T01A 4KAVA 3UNYA 3MK2A 1ANJA 2IUCA 5EGHA 5INHA 1P49A 2W5SA 3M8WA 4UOPA 1K7HA 5L0EA 4LR9A 1HDHA 5IJSA 1E1ZP 2GSNA 3Q3QA 3BDGB 3M8ZA 2GLQA 3WAXA 3UN3A 5L0KA 3NKNA 5DLWA 3T00A 2W5TA 3BDHA 3CMRA 4LR2A 3WAYA 5HRTA 1ALJA 1URBA 3MK1A 4GTWA 5C66A 3A52A 2D1GA 1EJJA 1EI6A 1N2KA 1KHNA 4GTZA 3DPCA 2X98A 4ZG6A 3NKOA 4ZG7A 4ZG9A 1Y7AA 5L0BA 3IGZB 2XRGA 2GSOA 3NKPA 1E33P 1ED8A 5LRMA 4QAXA 5GOVA 1EW9A 2W5XA 1KH7A 1N2LA 4LQYA 1ED9A 1URAA 1E3CP 4UPIA 4LREA 4B56A 1AJAA 1KHJA 2RH6A 1SHNA 2W5WA 2XR9A 4FDIA 2QZUA 5IJQA 5K4PA 1SHQA 4CYSA 5LRNA 1ALKA 3OT9A 3NKRA 3MK0A 2IUCB 1KH4A 2W5QA 4FDJA 2W5VA 3M8YA 4KAYA 1ELYA 3KD8A 3UN5A 4LRDA 2VQRA 1AJDA 1ALHA 2W8SA 3B5QA 4KM4A 4MHXA 5KXAA 4GTXA 3DYCA 1B8JA 1ALIA 2GSUA 4TN0A 1AJBA 3TX0A 1AJCA 2GA3A 1ANIA 3M7VA 4UPLA 1FSUA 2ANHA 2W5RA 1ZEBA 1KH5A 4CXKA 1ZEFA 1O98A 4UORA 1AUKA 2W8DA 4UOOA 4N7TA 1KHKA 4CXUA 5GRRA 3NVLA 3E2DA 4LRBA 3BDGA 1EW8A 4NWXA 5EGEA 4ZGAA 3NKQA 3WBHA 3SZZA 1KH9A 3WAVA 4LRAA 1KHLA 3IGYB 3T02A 4MIVA 3NKMA 3BDFA 4KJGA 4CYRA 4GTYA 5DLVA 3IDDA 4LRFA 2IFYA 4LR7A 5LIAA 1O99A 4MY4A 3WAWA 1EW2A 1HQAA 5DLTA 2G9YA 1ELXA 4LRCA 1E2SP 1ZEDA 5AJ9A 1EQJA 3TWZA 3UN2A 3SZYA 3UO0A 3ED4A 5TJ3A 5LQQA 1HJKA 3TG0A 4YR1A 4CXSA 4UPKA 1ELZA 2ZKTA 4UPHA 4NWJA 3LXQA 4LR8A 4KJDA
chains in the Genus database with same CATH superfamily
1Y6VA 3T01A 4KAVA 3UNYA 3MK2A 1ANJA 2IUCA 5EGHA 5INHA 1P49A 2W5SA 3M8WA 4UOPA 1K7HA 5L0EA 4LR9A 1HDHA 5IJSA 1E1ZP 2GSNA 3Q3QA 3BDGB 3M8ZA 2GLQA 3WAXA 3UN3A 5L0KA 3NKNA 5DLWA 3T00A 2W5TA 3BDHA 3CMRA 4LR2A 3WAYA 5HRTA 1ALJA 1URBA 3MK1A 4GTWA 5C66A 3A52A 2D1GA 1EJJA 1EI6A 1N2KA 1KHNA 4GTZA 3DPCA 2X98A 4ZG6A 3NKOA 4ZG7A 4ZG9A 1Y7AA 5L0BA 3IGZB 2XRGA 2GSOA 3NKPA 1E33P 1ED8A 5LRMA 4QAXA 5GOVA 1EW9A 2W5XA 1KH7A 1N2LA 4LQYA 1ED9A 1URAA 1E3CP 4UPIA 4LREA 4B56A 1AJAA 1KHJA 2RH6A 1SHNA 2W5WA 2XR9A 4FDIA 2QZUA 5IJQA 5K4PA 1SHQA 4CYSA 5LRNA 1ALKA 3OT9A 3NKRA 3MK0A 2IUCB 1KH4A 2W5QA 4FDJA 2W5VA 3M8YA 4KAYA 1ELYA 3KD8A 3UN5A 4LRDA 2VQRA 1AJDA 1ALHA 2W8SA 3B5QA 4KM4A 4MHXA 5KXAA 4GTXA 3DYCA 1B8JA 1ALIA 2GSUA 4TN0A 1AJBA 3TX0A 1AJCA 2GA3A 1ANIA 3M7VA 4UPLA 1FSUA 2ANHA 2W5RA 1ZEBA 1KH5A 4CXKA 1ZEFA 1O98A 4UORA 1AUKA 2W8DA 4UOOA 4N7TA 1KHKA 4CXUA 5GRRA 3NVLA 3E2DA 4LRBA 3BDGA 1EW8A 4NWXA 5EGEA 4ZGAA 3NKQA 3WBHA 3SZZA 1KH9A 3WAVA 4LRAA 1KHLA 3IGYB 3T02A 4MIVA 3NKMA 3BDFA 4KJGA 4CYRA 4GTYA 5DLVA 3IDDA 4LRFA 2IFYA 4LR7A 5LIAA 1O99A 4MY4A 3WAWA 1EW2A 1HQAA 5DLTA 2G9YA 1ELXA 4LRCA 1E2SP 1ZEDA 5AJ9A 1EQJA 3TWZA 3UN2A 3SZYA 3UO0A 3ED4A 5TJ3A 5LQQA 1HJKA 3TG0A 4YR1A 4CXSA 4UPKA 1ELZA 2ZKTA 4UPHA 4NWJA 3LXQA 4LR8A 4KJDA
chains in the Genus database with same CATH topology
1Y6VA 3T01A 4KAVA 3UNYA 3MK2A 1ANJA 2IUCA 5EGHA 5INHA 1P49A 2W5SA 3M8WA 4UOPA 1K7HA 5L0EA 4LR9A 1HDHA 5IJSA 1E1ZP 2GSNA 3Q3QA 3BDGB 3M8ZA 2GLQA 3WAXA 3UN3A 5L0KA 3NKNA 5DLWA 3T00A 2W5TA 3BDHA 3CMRA 4LR2A 3WAYA 5HRTA 1ALJA 1URBA 3MK1A 4GTWA 5C66A 3A52A 2D1GA 1EJJA 1EI6A 1N2KA 1KHNA 4GTZA 3DPCA 2X98A 4ZG6A 3NKOA 4ZG7A 4ZG9A 1Y7AA 5L0BA 3IGZB 2XRGA 2GSOA 3NKPA 1E33P 1ED8A 5LRMA 4QAXA 5GOVA 1EW9A 2W5XA 1KH7A 1N2LA 4LQYA 1ED9A 1URAA 1E3CP 4UPIA 4LREA 4B56A 1AJAA 1KHJA 2RH6A 1SHNA 2W5WA 2XR9A 4FDIA 2QZUA 5IJQA 5K4PA 1SHQA 4CYSA 5LRNA 1ALKA 3OT9A 3NKRA 3MK0A 2IUCB 1KH4A 2W5QA 4FDJA 2W5VA 3M8YA 4KAYA 1ELYA 3KD8A 3UN5A 4LRDA 2VQRA 1AJDA 1ALHA 2W8SA 3B5QA 4KM4A 4MHXA 5KXAA 4GTXA 3DYCA 1B8JA 1ALIA 2GSUA 4TN0A 1AJBA 3TX0A 1AJCA 2GA3A 1ANIA 3M7VA 4UPLA 1FSUA 2ANHA 2W5RA 1ZEBA 1KH5A 4CXKA 1ZEFA 1O98A 4UORA 1AUKA 2W8DA 4UOOA 4N7TA 1KHKA 4CXUA 5GRRA 3NVLA 3E2DA 4LRBA 3BDGA 1EW8A 4NWXA 5EGEA 4ZGAA 3NKQA 3WBHA 3SZZA 1KH9A 3WAVA 4LRAA 1KHLA 3IGYB 3T02A 4MIVA 3NKMA 3BDFA 4KJGA 4CYRA 4GTYA 5DLVA 3IDDA 4LRFA 2IFYA 4LR7A 5LIAA 1O99A 4MY4A 3WAWA 1EW2A 1HQAA 5DLTA 2G9YA 1ELXA 4LRCA 1E2SP 1ZEDA 5AJ9A 1EQJA 3TWZA 3UN2A 3SZYA 3UO0A 3ED4A 5TJ3A 5LQQA 1HJKA 3TG0A 4YR1A 4CXSA 4UPKA 1ELZA 2ZKTA 4UPHA 4NWJA 3LXQA 4LR8A 4KJDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y6V A;  3T01 A;  4KAV A;  3UNY A;  3MK2 A;  1ANJ A;  2IUC A;  5EGH A;  5INH A;  1P49 A;  2W5S A;  3M8W A;  4UOP A;  1K7H A;  5L0E A;  4LR9 A;  1HDH A;  5IJS A;  1E1Z P;  2GSN A;  3Q3Q A;  3BDG B;  3M8Z A;  2GLQ A;  3WAX A;  3UN3 A;  5L0K A;  3NKN A;  5DLW A;  3T00 A;  2W5T A;  3BDH A;  3CMR A;  4LR2 A;  3WAY A;  5HRT A;  1ALJ A;  1URB A;  3MK1 A;  4GTW A;  5C66 A;  3A52 A;  2D1G A;  1EJJ A;  1EI6 A;  1N2K A;  1KHN A;  4GTZ A;  3DPC A;  2X98 A;  4ZG6 A;  3NKO A;  4ZG7 A;  4ZG9 A;  1Y7A A;  5L0B A;  3IGZ B;  2XRG A;  2GSO A;  3NKP A;  1E33 P;  1ED8 A;  5LRM A;  4QAX A;  5GOV A;  1EW9 A;  2W5X A;  1KH7 A;  1N2L A;  4LQY A;  1ED9 A;  1URA A;  1E3C P;  4UPI A;  4LRE A;  4B56 A;  1AJA A;  1KHJ A;  2RH6 A;  1SHN A;  2W5W A;  2XR9 A;  4FDI A;  2QZU A;  5IJQ A;  5K4P A;  1SHQ A;  4CYS A;  5LRN A;  1ALK A;  3OT9 A;  3NKR A;  3MK0 A;  2IUC B;  1KH4 A;  2W5Q A;  4FDJ A;  2W5V A;  3M8Y A;  4KAY A;  1ELY A;  3KD8 A;  3UN5 A;  4LRD A;  2VQR A;  1AJD A;  1ALH A;  2W8S A;  3B5Q A;  4KM4 A;  4MHX A;  5KXA A;  4GTX A;  3DYC A;  1B8J A;  1ALI A;  2GSU A;  4TN0 A;  1AJB A;  3TX0 A;  1AJC A;  2GA3 A;  1ANI A;  3M7V A;  4UPL A;  1FSU A;  2ANH A;  2W5R A;  1ZEB A;  1KH5 A;  4CXK A;  1ZEF A;  1O98 A;  4UOR A;  1AUK A;  2W8D A;  4UOO A;  4N7T A;  1KHK A;  4CXU A;  5GRR A;  3NVL A;  3E2D A;  4LRB A;  3BDG A;  1EW8 A;  4NWX A;  5EGE A;  4ZGA A;  3NKQ A;  3WBH A;  3SZZ A;  1KH9 A;  3WAV A;  4LRA A;  1KHL A;  3IGY B;  3T02 A;  4MIV A;  3NKM A;  3BDF A;  4KJG A;  4CYR A;  4GTY A;  5DLV A;  3IDD A;  4LRF A;  2IFY A;  4LR7 A;  5LIA A;  1O99 A;  4MY4 A;  3WAW A;  1EW2 A;  1HQA A;  5DLT A;  2G9Y A;  1ELX A;  4LRC A;  1E2S P;  1ZED A;  5AJ9 A;  1EQJ A;  3TWZ A;  3UN2 A;  3SZY A;  3UO0 A;  3ED4 A;  5TJ3 A;  5LQQ A;  1HJK A;  3TG0 A;  4YR1 A;  4CXS A;  4UPK A;  1ELZ A;  2ZKT A;  4UPH A;  4NWJ A;  3LXQ A;  4LR8 A;  4KJD A; 
#chains in the Genus database with same CATH topology
 1Y6V A;  3T01 A;  4KAV A;  3UNY A;  3MK2 A;  1ANJ A;  2IUC A;  5EGH A;  5INH A;  1P49 A;  2W5S A;  3M8W A;  4UOP A;  1K7H A;  5L0E A;  4LR9 A;  1HDH A;  5IJS A;  1E1Z P;  2GSN A;  3Q3Q A;  3BDG B;  3M8Z A;  2GLQ A;  3WAX A;  3UN3 A;  5L0K A;  3NKN A;  5DLW A;  3T00 A;  2W5T A;  3BDH A;  3CMR A;  4LR2 A;  3WAY A;  5HRT A;  1ALJ A;  1URB A;  3MK1 A;  4GTW A;  5C66 A;  3A52 A;  2D1G A;  1EJJ A;  1EI6 A;  1N2K A;  1KHN A;  4GTZ A;  3DPC A;  2X98 A;  4ZG6 A;  3NKO A;  4ZG7 A;  4ZG9 A;  1Y7A A;  5L0B A;  3IGZ B;  2XRG A;  2GSO A;  3NKP A;  1E33 P;  1ED8 A;  5LRM A;  4QAX A;  5GOV A;  1EW9 A;  2W5X A;  1KH7 A;  1N2L A;  4LQY A;  1ED9 A;  1URA A;  1E3C P;  4UPI A;  4LRE A;  4B56 A;  1AJA A;  1KHJ A;  2RH6 A;  1SHN A;  2W5W A;  2XR9 A;  4FDI A;  2QZU A;  5IJQ A;  5K4P A;  1SHQ A;  4CYS A;  5LRN A;  1ALK A;  3OT9 A;  3NKR A;  3MK0 A;  2IUC B;  1KH4 A;  2W5Q A;  4FDJ A;  2W5V A;  3M8Y A;  4KAY A;  1ELY A;  3KD8 A;  3UN5 A;  4LRD A;  2VQR A;  1AJD A;  1ALH A;  2W8S A;  3B5Q A;  4KM4 A;  4MHX A;  5KXA A;  4GTX A;  3DYC A;  1B8J A;  1ALI A;  2GSU A;  4TN0 A;  1AJB A;  3TX0 A;  1AJC A;  2GA3 A;  1ANI A;  3M7V A;  4UPL A;  1FSU A;  2ANH A;  2W5R A;  1ZEB A;  1KH5 A;  4CXK A;  1ZEF A;  1O98 A;  4UOR A;  1AUK A;  2W8D A;  4UOO A;  4N7T A;  1KHK A;  4CXU A;  5GRR A;  3NVL A;  3E2D A;  4LRB A;  3BDG A;  1EW8 A;  4NWX A;  5EGE A;  4ZGA A;  3NKQ A;  3WBH A;  3SZZ A;  1KH9 A;  3WAV A;  4LRA A;  1KHL A;  3IGY B;  3T02 A;  4MIV A;  3NKM A;  3BDF A;  4KJG A;  4CYR A;  4GTY A;  5DLV A;  3IDD A;  4LRF A;  2IFY A;  4LR7 A;  5LIA A;  1O99 A;  4MY4 A;  3WAW A;  1EW2 A;  1HQA A;  5DLT A;  2G9Y A;  1ELX A;  4LRC A;  1E2S P;  1ZED A;  5AJ9 A;  1EQJ A;  3TWZ A;  3UN2 A;  3SZY A;  3UO0 A;  3ED4 A;  5TJ3 A;  5LQQ A;  1HJK A;  3TG0 A;  4YR1 A;  4CXS A;  4UPK A;  1ELZ A;  2ZKT A;  4UPH A;  4NWJ A;  3LXQ A;  4LR8 A;  4KJD A; 
#chains in the Genus database with same CATH homology
 1Y6V A;  3T01 A;  4KAV A;  3UNY A;  3MK2 A;  1ANJ A;  2IUC A;  5EGH A;  5INH A;  1P49 A;  2W5S A;  3M8W A;  4UOP A;  1K7H A;  5L0E A;  4LR9 A;  1HDH A;  5IJS A;  1E1Z P;  2GSN A;  3Q3Q A;  3BDG B;  3M8Z A;  2GLQ A;  3WAX A;  3UN3 A;  5L0K A;  3NKN A;  5DLW A;  3T00 A;  2W5T A;  3BDH A;  3CMR A;  4LR2 A;  3WAY A;  5HRT A;  1ALJ A;  1URB A;  3MK1 A;  4GTW A;  5C66 A;  3A52 A;  2D1G A;  1EJJ A;  1EI6 A;  1N2K A;  1KHN A;  4GTZ A;  3DPC A;  2X98 A;  4ZG6 A;  3NKO A;  4ZG7 A;  4ZG9 A;  1Y7A A;  5L0B A;  3IGZ B;  2XRG A;  2GSO A;  3NKP A;  1E33 P;  1ED8 A;  5LRM A;  4QAX A;  5GOV A;  1EW9 A;  2W5X A;  1KH7 A;  1N2L A;  4LQY A;  1ED9 A;  1URA A;  1E3C P;  4UPI A;  4LRE A;  4B56 A;  1AJA A;  1KHJ A;  2RH6 A;  1SHN A;  2W5W A;  2XR9 A;  4FDI A;  2QZU A;  5IJQ A;  5K4P A;  1SHQ A;  4CYS A;  5LRN A;  1ALK A;  3OT9 A;  3NKR A;  3MK0 A;  2IUC B;  1KH4 A;  2W5Q A;  4FDJ A;  2W5V A;  3M8Y A;  4KAY A;  1ELY A;  3KD8 A;  3UN5 A;  4LRD A;  2VQR A;  1AJD A;  1ALH A;  2W8S A;  3B5Q A;  4KM4 A;  4MHX A;  5KXA A;  4GTX A;  3DYC A;  1B8J A;  1ALI A;  2GSU A;  4TN0 A;  1AJB A;  3TX0 A;  1AJC A;  2GA3 A;  1ANI A;  3M7V A;  4UPL A;  1FSU A;  2ANH A;  2W5R A;  1ZEB A;  1KH5 A;  4CXK A;  1ZEF A;  1O98 A;  4UOR A;  1AUK A;  2W8D A;  4UOO A;  4N7T A;  1KHK A;  4CXU A;  5GRR A;  3NVL A;  3E2D A;  4LRB A;  3BDG A;  1EW8 A;  4NWX A;  5EGE A;  4ZGA A;  3NKQ A;  3WBH A;  3SZZ A;  1KH9 A;  3WAV A;  4LRA A;  1KHL A;  3IGY B;  3T02 A;  4MIV A;  3NKM A;  3BDF A;  4KJG A;  4CYR A;  4GTY A;  5DLV A;  3IDD A;  4LRF A;  2IFY A;  4LR7 A;  5LIA A;  1O99 A;  4MY4 A;  3WAW A;  1EW2 A;  1HQA A;  5DLT A;  2G9Y A;  1ELX A;  4LRC A;  1E2S P;  1ZED A;  5AJ9 A;  1EQJ A;  3TWZ A;  3UN2 A;  3SZY A;  3UO0 A;  3ED4 A;  5TJ3 A;  5LQQ A;  1HJK A;  3TG0 A;  4YR1 A;  4CXS A;  4UPK A;  1ELZ A;  2ZKT A;  4UPH A;  4NWJ A;  3LXQ A;  4LR8 A;  4KJD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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