3MK2A

Placental alkaline phosphatase complexed with phe
Total Genus 184
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
total genus 184
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk2A00
1KH9A 4MHXA 4N7TA 3CMRA 1AJCA 3DPCA 5INHA 1K7HA 4YR1A 5LRMA 1KHKA 4GTXA 3WAWA 4LRAA 5DLTA 3UO0A 2W8SA 4ZG9A 1AJBA 3NKPA 4ZG6A 4UPHA 3M8ZA 3M7VA 4LRBA 4TN0A 1O98A 3TX0A 3SZYA 5GRRA 3UN3A 4CXUA 1EQJA 4NWJA 2W5XA 4GTYA 3B5QA 2GSOA 3OT9A 4KJGA 4CYSA 5GOVA 3NKOA 3IGZB 3MK2A 5EGHA 1KHLA 3ED4A 3NKNA 1E1ZP 1KHJA 3BDFA 1ELYA 4CYRA 1E2SP 4UPLA 1ALJA 3NKQA 4FDIA 3UNYA 1ALIA 5L0EA 1ZEFA 1ZEDA 3T01A 4MY4A 3LXQA 4LR2A 4LRDA 3BDGA 3SZZA 2GSUA 4GTZA 1E33P 1ELXA 1HQAA 2RH6A 2IUCA 3UN2A 5IJSA 1EW9A 5LIAA 2W5QA 4B56A 2W5VA 5LQQA 3TWZA 1P49A 2XR9A 2GA3A 2ANHA 1SHNA 4KAVA 5HRTA 3MK1A 3A52A 1ANJA 3NKMA 2XRGA 1KH4A 1ED8A 1ED9A 3T00A 1URBA 2X98A 2IUCB 5KXAA 4LQYA 4ZGAA 1URAA 3KD8A 5AJ9A 1ALHA 1KH7A 1O99A 1AJDA 2W5TA 1HJKA 1SHQA 2IFYA 3TG0A 4LR9A 3BDHA 4CXSA 1E3CP 1EW8A 4KJDA 3WBHA 2GSNA 3WAXA 1EJJA 2W5WA 4ZG7A 4LR8A 5TJ3A 3M8YA 4LREA 1AJAA 4NWXA 1N2LA 2ZKTA 1ZEBA 2GLQA 3M8WA 1HDHA 1ELZA 4FDJA 4GTWA 3T02A 5LRNA 5K4PA 2G9YA 2W8DA 3WAYA 4UOOA 3IDDA 2W5RA 1KH5A 4CXKA 3UN5A 5EGEA 1B8JA 1Y6VA 3BDGB 4QAXA 5DLWA 3WAVA 4MIVA 3NVLA 5C66A 3NKRA 4LR7A 1FSUA 4UPKA 1Y7AA 4UORA 1AUKA 1KHNA 1N2KA 5DLVA 1ALKA 4KAYA 3DYCA 3Q3QA 5L0BA 4LRFA 3MK0A 4KM4A 2D1GA 2QZUA 4UPIA 1ANIA 2VQRA 4UOPA 3IGYB 1EW2A 2W5SA 3E2DA 5IJQA 1EI6A 4LRCA 5L0KA
chains in the Genus database with same CATH superfamily
1KH9A 4MHXA 4N7TA 3CMRA 1AJCA 3DPCA 5INHA 1K7HA 4YR1A 5LRMA 1KHKA 4GTXA 3WAWA 4LRAA 5DLTA 3UO0A 2W8SA 4ZG9A 1AJBA 3NKPA 4ZG6A 4UPHA 3M8ZA 3M7VA 4LRBA 4TN0A 1O98A 3TX0A 3SZYA 5GRRA 3UN3A 4CXUA 1EQJA 4NWJA 2W5XA 4GTYA 3B5QA 2GSOA 3OT9A 4KJGA 4CYSA 5GOVA 3NKOA 3IGZB 3MK2A 5EGHA 1KHLA 3ED4A 3NKNA 1E1ZP 1KHJA 3BDFA 1ELYA 4CYRA 1E2SP 4UPLA 1ALJA 3NKQA 4FDIA 3UNYA 1ALIA 5L0EA 1ZEFA 1ZEDA 3T01A 4MY4A 3LXQA 4LR2A 4LRDA 3BDGA 3SZZA 2GSUA 4GTZA 1E33P 1ELXA 1HQAA 2RH6A 2IUCA 3UN2A 5IJSA 1EW9A 5LIAA 2W5QA 4B56A 2W5VA 5LQQA 3TWZA 1P49A 2XR9A 2GA3A 2ANHA 1SHNA 4KAVA 5HRTA 3MK1A 3A52A 1ANJA 3NKMA 2XRGA 1KH4A 1ED8A 1ED9A 3T00A 1URBA 2X98A 2IUCB 5KXAA 4LQYA 4ZGAA 1URAA 3KD8A 5AJ9A 1ALHA 1KH7A 1O99A 1AJDA 2W5TA 1HJKA 1SHQA 2IFYA 3TG0A 4LR9A 3BDHA 4CXSA 1E3CP 1EW8A 4KJDA 3WBHA 2GSNA 3WAXA 1EJJA 2W5WA 4ZG7A 4LR8A 5TJ3A 3M8YA 4LREA 1AJAA 4NWXA 1N2LA 2ZKTA 1ZEBA 2GLQA 3M8WA 1HDHA 1ELZA 4FDJA 4GTWA 3T02A 5LRNA 5K4PA 2G9YA 2W8DA 3WAYA 4UOOA 3IDDA 2W5RA 1KH5A 4CXKA 3UN5A 5EGEA 1B8JA 1Y6VA 3BDGB 4QAXA 5DLWA 3WAVA 4MIVA 3NVLA 5C66A 3NKRA 4LR7A 1FSUA 4UPKA 1Y7AA 4UORA 1AUKA 1KHNA 1N2KA 5DLVA 1ALKA 4KAYA 3DYCA 3Q3QA 5L0BA 4LRFA 3MK0A 4KM4A 2D1GA 2QZUA 4UPIA 1ANIA 2VQRA 4UOPA 3IGYB 1EW2A 2W5SA 3E2DA 5IJQA 1EI6A 4LRCA 5L0KA
chains in the Genus database with same CATH topology
1KH9A 4MHXA 4N7TA 3CMRA 1AJCA 3DPCA 5INHA 1K7HA 4YR1A 5LRMA 1KHKA 4GTXA 3WAWA 4LRAA 5DLTA 3UO0A 2W8SA 4ZG9A 1AJBA 3NKPA 4ZG6A 4UPHA 3M8ZA 3M7VA 4LRBA 4TN0A 1O98A 3TX0A 3SZYA 5GRRA 3UN3A 4CXUA 1EQJA 4NWJA 2W5XA 4GTYA 3B5QA 2GSOA 3OT9A 4KJGA 4CYSA 5GOVA 3NKOA 3IGZB 3MK2A 5EGHA 1KHLA 3ED4A 3NKNA 1E1ZP 1KHJA 3BDFA 1ELYA 4CYRA 1E2SP 4UPLA 1ALJA 3NKQA 4FDIA 3UNYA 1ALIA 5L0EA 1ZEFA 1ZEDA 3T01A 4MY4A 3LXQA 4LR2A 4LRDA 3BDGA 3SZZA 2GSUA 4GTZA 1E33P 1ELXA 1HQAA 2RH6A 2IUCA 3UN2A 5IJSA 1EW9A 5LIAA 2W5QA 4B56A 2W5VA 5LQQA 3TWZA 1P49A 2XR9A 2GA3A 2ANHA 1SHNA 4KAVA 5HRTA 3MK1A 3A52A 1ANJA 3NKMA 2XRGA 1KH4A 1ED8A 1ED9A 3T00A 1URBA 2X98A 2IUCB 5KXAA 4LQYA 4ZGAA 1URAA 3KD8A 5AJ9A 1ALHA 1KH7A 1O99A 1AJDA 2W5TA 1HJKA 1SHQA 2IFYA 3TG0A 4LR9A 3BDHA 4CXSA 1E3CP 1EW8A 4KJDA 3WBHA 2GSNA 3WAXA 1EJJA 2W5WA 4ZG7A 4LR8A 5TJ3A 3M8YA 4LREA 1AJAA 4NWXA 1N2LA 2ZKTA 1ZEBA 2GLQA 3M8WA 1HDHA 1ELZA 4FDJA 4GTWA 3T02A 5LRNA 5K4PA 2G9YA 2W8DA 3WAYA 4UOOA 3IDDA 2W5RA 1KH5A 4CXKA 3UN5A 5EGEA 1B8JA 1Y6VA 3BDGB 4QAXA 5DLWA 3WAVA 4MIVA 3NVLA 5C66A 3NKRA 4LR7A 1FSUA 4UPKA 1Y7AA 4UORA 1AUKA 1KHNA 1N2KA 5DLVA 1ALKA 4KAYA 3DYCA 3Q3QA 5L0BA 4LRFA 3MK0A 4KM4A 2D1GA 2QZUA 4UPIA 1ANIA 2VQRA 4UOPA 3IGYB 1EW2A 2W5SA 3E2DA 5IJQA 1EI6A 4LRCA 5L0KA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1KH9 A;  4MHX A;  4N7T A;  3CMR A;  1AJC A;  3DPC A;  5INH A;  1K7H A;  4YR1 A;  5LRM A;  1KHK A;  4GTX A;  3WAW A;  4LRA A;  5DLT A;  3UO0 A;  2W8S A;  4ZG9 A;  1AJB A;  3NKP A;  4ZG6 A;  4UPH A;  3M8Z A;  3M7V A;  4LRB A;  4TN0 A;  1O98 A;  3TX0 A;  3SZY A;  5GRR A;  3UN3 A;  4CXU A;  1EQJ A;  4NWJ A;  2W5X A;  4GTY A;  3B5Q A;  2GSO A;  3OT9 A;  4KJG A;  4CYS A;  5GOV A;  3NKO A;  3IGZ B;  3MK2 A;  5EGH A;  1KHL A;  3ED4 A;  3NKN A;  1E1Z P;  1KHJ A;  3BDF A;  1ELY A;  4CYR A;  1E2S P;  4UPL A;  1ALJ A;  3NKQ A;  4FDI A;  3UNY A;  1ALI A;  5L0E A;  1ZEF A;  1ZED A;  3T01 A;  4MY4 A;  3LXQ A;  4LR2 A;  4LRD A;  3BDG A;  3SZZ A;  2GSU A;  4GTZ A;  1E33 P;  1ELX A;  1HQA A;  2RH6 A;  2IUC A;  3UN2 A;  5IJS A;  1EW9 A;  5LIA A;  2W5Q A;  4B56 A;  2W5V A;  5LQQ A;  3TWZ A;  1P49 A;  2XR9 A;  2GA3 A;  2ANH A;  1SHN A;  4KAV A;  5HRT A;  3MK1 A;  3A52 A;  1ANJ A;  3NKM A;  2XRG A;  1KH4 A;  1ED8 A;  1ED9 A;  3T00 A;  1URB A;  2X98 A;  2IUC B;  5KXA A;  4LQY A;  4ZGA A;  1URA A;  3KD8 A;  5AJ9 A;  1ALH A;  1KH7 A;  1O99 A;  1AJD A;  2W5T A;  1HJK A;  1SHQ A;  2IFY A;  3TG0 A;  4LR9 A;  3BDH A;  4CXS A;  1E3C P;  1EW8 A;  4KJD A;  3WBH A;  2GSN A;  3WAX A;  1EJJ A;  2W5W A;  4ZG7 A;  4LR8 A;  5TJ3 A;  3M8Y A;  4LRE A;  1AJA A;  4NWX A;  1N2L A;  2ZKT A;  1ZEB A;  2GLQ A;  3M8W A;  1HDH A;  1ELZ A;  4FDJ A;  4GTW A;  3T02 A;  5LRN A;  5K4P A;  2G9Y A;  2W8D A;  3WAY A;  4UOO A;  3IDD A;  2W5R A;  1KH5 A;  4CXK A;  3UN5 A;  5EGE A;  1B8J A;  1Y6V A;  3BDG B;  4QAX A;  5DLW A;  3WAV A;  4MIV A;  3NVL A;  5C66 A;  3NKR A;  4LR7 A;  1FSU A;  4UPK A;  1Y7A A;  4UOR A;  1AUK A;  1KHN A;  1N2K A;  5DLV A;  1ALK A;  4KAY A;  3DYC A;  3Q3Q A;  5L0B A;  4LRF A;  3MK0 A;  4KM4 A;  2D1G A;  2QZU A;  4UPI A;  1ANI A;  2VQR A;  4UOP A;  3IGY B;  1EW2 A;  2W5S A;  3E2D A;  5IJQ A;  1EI6 A;  4LRC A;  5L0K A; 
#chains in the Genus database with same CATH topology
 1KH9 A;  4MHX A;  4N7T A;  3CMR A;  1AJC A;  3DPC A;  5INH A;  1K7H A;  4YR1 A;  5LRM A;  1KHK A;  4GTX A;  3WAW A;  4LRA A;  5DLT A;  3UO0 A;  2W8S A;  4ZG9 A;  1AJB A;  3NKP A;  4ZG6 A;  4UPH A;  3M8Z A;  3M7V A;  4LRB A;  4TN0 A;  1O98 A;  3TX0 A;  3SZY A;  5GRR A;  3UN3 A;  4CXU A;  1EQJ A;  4NWJ A;  2W5X A;  4GTY A;  3B5Q A;  2GSO A;  3OT9 A;  4KJG A;  4CYS A;  5GOV A;  3NKO A;  3IGZ B;  3MK2 A;  5EGH A;  1KHL A;  3ED4 A;  3NKN A;  1E1Z P;  1KHJ A;  3BDF A;  1ELY A;  4CYR A;  1E2S P;  4UPL A;  1ALJ A;  3NKQ A;  4FDI A;  3UNY A;  1ALI A;  5L0E A;  1ZEF A;  1ZED A;  3T01 A;  4MY4 A;  3LXQ A;  4LR2 A;  4LRD A;  3BDG A;  3SZZ A;  2GSU A;  4GTZ A;  1E33 P;  1ELX A;  1HQA A;  2RH6 A;  2IUC A;  3UN2 A;  5IJS A;  1EW9 A;  5LIA A;  2W5Q A;  4B56 A;  2W5V A;  5LQQ A;  3TWZ A;  1P49 A;  2XR9 A;  2GA3 A;  2ANH A;  1SHN A;  4KAV A;  5HRT A;  3MK1 A;  3A52 A;  1ANJ A;  3NKM A;  2XRG A;  1KH4 A;  1ED8 A;  1ED9 A;  3T00 A;  1URB A;  2X98 A;  2IUC B;  5KXA A;  4LQY A;  4ZGA A;  1URA A;  3KD8 A;  5AJ9 A;  1ALH A;  1KH7 A;  1O99 A;  1AJD A;  2W5T A;  1HJK A;  1SHQ A;  2IFY A;  3TG0 A;  4LR9 A;  3BDH A;  4CXS A;  1E3C P;  1EW8 A;  4KJD A;  3WBH A;  2GSN A;  3WAX A;  1EJJ A;  2W5W A;  4ZG7 A;  4LR8 A;  5TJ3 A;  3M8Y A;  4LRE A;  1AJA A;  4NWX A;  1N2L A;  2ZKT A;  1ZEB A;  2GLQ A;  3M8W A;  1HDH A;  1ELZ A;  4FDJ A;  4GTW A;  3T02 A;  5LRN A;  5K4P A;  2G9Y A;  2W8D A;  3WAY A;  4UOO A;  3IDD A;  2W5R A;  1KH5 A;  4CXK A;  3UN5 A;  5EGE A;  1B8J A;  1Y6V A;  3BDG B;  4QAX A;  5DLW A;  3WAV A;  4MIV A;  3NVL A;  5C66 A;  3NKR A;  4LR7 A;  1FSU A;  4UPK A;  1Y7A A;  4UOR A;  1AUK A;  1KHN A;  1N2K A;  5DLV A;  1ALK A;  4KAY A;  3DYC A;  3Q3Q A;  5L0B A;  4LRF A;  3MK0 A;  4KM4 A;  2D1G A;  2QZU A;  4UPI A;  1ANI A;  2VQR A;  4UOP A;  3IGY B;  1EW2 A;  2W5S A;  3E2D A;  5IJQ A;  1EI6 A;  4LRC A;  5L0K A; 
#chains in the Genus database with same CATH homology
 1KH9 A;  4MHX A;  4N7T A;  3CMR A;  1AJC A;  3DPC A;  5INH A;  1K7H A;  4YR1 A;  5LRM A;  1KHK A;  4GTX A;  3WAW A;  4LRA A;  5DLT A;  3UO0 A;  2W8S A;  4ZG9 A;  1AJB A;  3NKP A;  4ZG6 A;  4UPH A;  3M8Z A;  3M7V A;  4LRB A;  4TN0 A;  1O98 A;  3TX0 A;  3SZY A;  5GRR A;  3UN3 A;  4CXU A;  1EQJ A;  4NWJ A;  2W5X A;  4GTY A;  3B5Q A;  2GSO A;  3OT9 A;  4KJG A;  4CYS A;  5GOV A;  3NKO A;  3IGZ B;  3MK2 A;  5EGH A;  1KHL A;  3ED4 A;  3NKN A;  1E1Z P;  1KHJ A;  3BDF A;  1ELY A;  4CYR A;  1E2S P;  4UPL A;  1ALJ A;  3NKQ A;  4FDI A;  3UNY A;  1ALI A;  5L0E A;  1ZEF A;  1ZED A;  3T01 A;  4MY4 A;  3LXQ A;  4LR2 A;  4LRD A;  3BDG A;  3SZZ A;  2GSU A;  4GTZ A;  1E33 P;  1ELX A;  1HQA A;  2RH6 A;  2IUC A;  3UN2 A;  5IJS A;  1EW9 A;  5LIA A;  2W5Q A;  4B56 A;  2W5V A;  5LQQ A;  3TWZ A;  1P49 A;  2XR9 A;  2GA3 A;  2ANH A;  1SHN A;  4KAV A;  5HRT A;  3MK1 A;  3A52 A;  1ANJ A;  3NKM A;  2XRG A;  1KH4 A;  1ED8 A;  1ED9 A;  3T00 A;  1URB A;  2X98 A;  2IUC B;  5KXA A;  4LQY A;  4ZGA A;  1URA A;  3KD8 A;  5AJ9 A;  1ALH A;  1KH7 A;  1O99 A;  1AJD A;  2W5T A;  1HJK A;  1SHQ A;  2IFY A;  3TG0 A;  4LR9 A;  3BDH A;  4CXS A;  1E3C P;  1EW8 A;  4KJD A;  3WBH A;  2GSN A;  3WAX A;  1EJJ A;  2W5W A;  4ZG7 A;  4LR8 A;  5TJ3 A;  3M8Y A;  4LRE A;  1AJA A;  4NWX A;  1N2L A;  2ZKT A;  1ZEB A;  2GLQ A;  3M8W A;  1HDH A;  1ELZ A;  4FDJ A;  4GTW A;  3T02 A;  5LRN A;  5K4P A;  2G9Y A;  2W8D A;  3WAY A;  4UOO A;  3IDD A;  2W5R A;  1KH5 A;  4CXK A;  3UN5 A;  5EGE A;  1B8J A;  1Y6V A;  3BDG B;  4QAX A;  5DLW A;  3WAV A;  4MIV A;  3NVL A;  5C66 A;  3NKR A;  4LR7 A;  1FSU A;  4UPK A;  1Y7A A;  4UOR A;  1AUK A;  1KHN A;  1N2K A;  5DLV A;  1ALK A;  4KAY A;  3DYC A;  3Q3Q A;  5L0B A;  4LRF A;  3MK0 A;  4KM4 A;  2D1G A;  2QZU A;  4UPI A;  1ANI A;  2VQR A;  4UOP A;  3IGY B;  1EW2 A;  2W5S A;  3E2D A;  5IJQ A;  1EI6 A;  4LRC A;  5L0K A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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