4KNGE

Crystal structure of human lgr5-rspo1-rnf43
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
149
structure length
149
Chain Sequence
QKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of R-spondin recognition by LGR5 and RNF43.
pubmed doi rcsb
molecule tags Signaling protein, membrane protein
source organism Homo sapiens
molecule keywords Leucine-rich repeat-containing G-protein coupled receptor 5
total genus 32
structure length 149
sequence length 149
chains with identical sequence F
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2013-05-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF18212 ZNRF_3_ecto ZNRF-3 Ectodomain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.30.30 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase; domain 1 Glucose Oxidase; domain 1 4kngE00
3FECA 2XEFA 4LQGA 2EK8A 2XEGA 4OC1A 2C6GA 3FF3A 4X3RA 3BI0A 3SJGA 3KASA 2C6CA 4OC3A 3VTAA 5IB9A 4OC2A 2PVVA 1XF1A 5F09A 3IWWA 4MCRA 2C6PA 4P45A 2OR4A 1V6CA 2XEIA 2EK9A 4C9AA 4C99A 4KNGE 4TJXA 4MCQA 3FEEA 5ELYA 4NGQA 1Z8LA 3I6SA 3RBUA 4NGTA 4NGNA 3D7GA 5D29A 4P4BA 3SJXA 4C8CA 4C9UA 3S9NA 4C85A 2OOTA 4P4EA 3ICUA 4C8UA 4JYWA 4C8TA 4P4FA 3D7FA 2CIJA 4NGRA 4NGMA 1Y9ZA 1WVMA 4C8AA 4JZ0A 1CX8A 2JBJA 3SJFA 3BXMA 1DE4C 4NGPA 4TJVA 3S9MA 3IIBA 3EIFA 4P4IA 3FEDA 3D7DA 4CDJA 4OMEA 4OC5A 3BI1A 4OC0A 3SJEA 4MCSA 4C8FA 2JBKA 4YN3A 4NGSA 3I74A 4OC4A 2XEJA 4C9VA 3D7HA 3BHXA 4C84A 4P4DA 3S9LA 4P4JA 4TWEA 4C86A 4C8PA 4MCPA 4C9EA 4P44A 2PVWA 4CDKA 4W9YA 4C9RA
chains in the Genus database with same CATH superfamily
2YJTA 3TLZA 3FECA 3TLCA 2XEFA 3TYXA 3T05A 4LQGA 3K4IA 2EK8A 2XEGA 2DIKA 1ZRSA 3T07A 4OC1A 2HROA 2C6GA 3FF3A 4X3RA 3BI0A 1BXRB 3NOJA 3SJGA 3KASA 2EZCA 4E5SA 1NBWA 2C6CA 4J0NA 4OC3A 3VTAA 5IB9A 4OC2A 4MI1A 1XF1A 2FM4A 2PVVA 5F09A 3IWWA 4MCRA 2C6PA 4P45A 1J3LA 4JVOA 3T0TA 2OR4A 3EZAA 3GJZA 1C30B 1V6CA 2XEIA 5IR2A 2EK9A 4C9AA 3SR3A 4C99A 4KNGE 4TJXA 3U1BA 1C3OB 2D0OA 2R82A 3KRVA 3TLGA 4COBA 4MCQA 3FEEA 2AUMA 1A9XB 2X0SA 4INJA 1NXJA 4CO9A 2MP0A 1KC7A 3TLAA 5ELYA 4NGQA 1Z8LA 2PCNA 3G23A 3I6SA 3RBUA 1R61A 4NGTA 5K99A 5JVLA 3EZEA 3D7GA 4NGNA 5D29A 1KEEB 4P4BA 3SJXA 1JDEA 5JYBA 1VBHA 4C8CA 4C9UA 3TLBA 3S9NA 4C85A 3TLGB 2OOTA 4P4EA 3ICUA 4C8UA 4JYWA 4C8TA 1EZBA 4P4FA 3TLYA 3D7FA 2CIJA 4NGRA 4NGMA 3EZBA 1Y9ZA 1WVMA 4MJXA 4JZ0A 4C8AA 1ZL0A 2AUNA 3T5MA 1DIKA 1JDBC 3C8OA 5F5XA 1CX8A 4IIYA 2JBJA 1KBLA 2YJVA 2EZAA 3SJFA 3BXMA 1DE4C 4NGPA 4TJVA 2C5QA 4IIXA 3S9MA 3IIBA 3TLEA 2E28A 3EIFA 1CE8B 4P4IA 3FEDA 3D7DA 5FD8A 4CDJA 2B0AA 4CZ1A 1ZYMA 2HWGA 4OMEA 2GP4A 4OC5A 4E94A 3BI1A 4OC0A 3SJEA 2OLSA 4MCSA 4C8FA 2JBKA 1CS0B 4YN3A 4EYSA 4NGSA 3I74A 1EZAA 4M8DA 4OC4A 2XEJA 4C9VA 1VBGA 3D7HA 3BHXA 4C84A 4P4DA 3S9LA 2EZBA 1VI4A 1Q5XA 4COGA 4P4JA 4TWEA 4C86A 1M6VB 1T36B 3K9TA 2D0PA 4C8PA 2HI6A 4MCPA 1GGOA 4C9EA 4P44A 2PVWA 5F1YA 4CDKA 4H1HA 5F9MA 4W9YA 4C9RA
chains in the Genus database with same CATH topology
3FECA 2XEFA 4LQGA 2EK8A 2XEGA 4OC1A 2C6GA 3FF3A 4X3RA 3BI0A 3SJGA 3KASA 2C6CA 4OC3A 3VTAA 5IB9A 4OC2A 2PVVA 1XF1A 5F09A 3IWWA 4MCRA 2C6PA 4P45A 2OR4A 1V6CA 2XEIA 5IR2A 2EK9A 4C9AA 4C99A 4KNGE 4TJXA 4MCQA 3FEEA 5ELYA 4NGQA 1Z8LA 3I6SA 3RBUA 4NGTA 4NGNA 3D7GA 5D29A 4P4BA 3SJXA 4C8CA 4C9UA 3S9NA 4C85A 2OOTA 4P4EA 3ICUA 4C8UA 4JYWA 4C8TA 4P4FA 3D7FA 2CIJA 4NGRA 4NGMA 1Y9ZA 1WVMA 4C8AA 4JZ0A 1CX8A 2JBJA 3SJFA 3BXMA 1DE4C 4NGPA 4TJVA 2C5QA 3S9MA 3IIBA 3EIFA 4P4IA 3FEDA 3D7DA 4CDJA 4OMEA 2GP4A 4OC5A 3BI1A 4OC0A 3SJEA 4MCSA 4C8FA 2JBKA 4YN3A 4NGSA 3I74A 4OC4A 2XEJA 4C9VA 3D7HA 3BHXA 4C84A 4P4DA 3S9LA 4P4JA 4TWEA 4C86A 3K9TA 4C8PA 4MCPA 4C9EA 4P44A 2PVWA 4CDKA 4W9YA 4C9RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FEC A;  2XEF A;  4LQG A;  2EK8 A;  2XEG A;  4OC1 A;  2C6G A;  3FF3 A;  4X3R A;  3BI0 A;  3SJG A;  3KAS A;  2C6C A;  4OC3 A;  3VTA A;  5IB9 A;  4OC2 A;  2PVV A;  1XF1 A;  5F09 A;  3IWW A;  4MCR A;  2C6P A;  4P45 A;  2OR4 A;  1V6C A;  2XEI A;  2EK9 A;  4C9A A;  4C99 A;  4KNG E;  4TJX A;  4MCQ A;  3FEE A;  5ELY A;  4NGQ A;  1Z8L A;  3I6S A;  3RBU A;  4NGT A;  4NGN A;  3D7G A;  5D29 A;  4P4B A;  3SJX A;  4C8C A;  4C9U A;  3S9N A;  4C85 A;  2OOT A;  4P4E A;  3ICU A;  4C8U A;  4JYW A;  4C8T A;  4P4F A;  3D7F A;  2CIJ A;  4NGR A;  4NGM A;  1Y9Z A;  1WVM A;  4C8A A;  4JZ0 A;  1CX8 A;  2JBJ A;  3SJF A;  3BXM A;  1DE4 C;  4NGP A;  4TJV A;  3S9M A;  3IIB A;  3EIF A;  4P4I A;  3FED A;  3D7D A;  4CDJ A;  4OME A;  4OC5 A;  3BI1 A;  4OC0 A;  3SJE A;  4MCS A;  4C8F A;  2JBK A;  4YN3 A;  4NGS A;  3I74 A;  4OC4 A;  2XEJ A;  4C9V A;  3D7H A;  3BHX A;  4C84 A;  4P4D A;  3S9L A;  4P4J A;  4TWE A;  4C86 A;  4C8P A;  4MCP A;  4C9E A;  4P44 A;  2PVW A;  4CDK A;  4W9Y A;  4C9R A; 
#chains in the Genus database with same CATH topology
 2YJT A;  3TLZ A;  3FEC A;  3TLC A;  2XEF A;  3TYX A;  3T05 A;  4LQG A;  3K4I A;  2EK8 A;  2XEG A;  2DIK A;  1ZRS A;  3T07 A;  4OC1 A;  2HRO A;  2C6G A;  3FF3 A;  4X3R A;  3BI0 A;  1BXR B;  3NOJ A;  3SJG A;  3KAS A;  2EZC A;  4E5S A;  1NBW A;  2C6C A;  4J0N A;  4OC3 A;  3VTA A;  5IB9 A;  4OC2 A;  4MI1 A;  1XF1 A;  2FM4 A;  2PVV A;  5F09 A;  3IWW A;  4MCR A;  2C6P A;  4P45 A;  1J3L A;  4JVO A;  3T0T A;  2OR4 A;  3EZA A;  3GJZ A;  1C30 B;  1V6C A;  2XEI A;  5IR2 A;  2EK9 A;  4C9A A;  3SR3 A;  4C99 A;  4KNG E;  4TJX A;  3U1B A;  1C3O B;  2D0O A;  2R82 A;  3KRV A;  3TLG A;  4COB A;  4MCQ A;  3FEE A;  2AUM A;  1A9X B;  2X0S A;  4INJ A;  1NXJ A;  4CO9 A;  2MP0 A;  1KC7 A;  3TLA A;  5ELY A;  4NGQ A;  1Z8L A;  2PCN A;  3G23 A;  3I6S A;  3RBU A;  1R61 A;  4NGT A;  5K99 A;  5JVL A;  3EZE A;  3D7G A;  4NGN A;  5D29 A;  1KEE B;  4P4B A;  3SJX A;  1JDE A;  5JYB A;  1VBH A;  4C8C A;  4C9U A;  3TLB A;  3S9N A;  4C85 A;  3TLG B;  2OOT A;  4P4E A;  3ICU A;  4C8U A;  4JYW A;  4C8T A;  1EZB A;  4P4F A;  3TLY A;  3D7F A;  2CIJ A;  4NGR A;  4NGM A;  3EZB A;  1Y9Z A;  1WVM A;  4MJX A;  4JZ0 A;  4C8A A;  1ZL0 A;  2AUN A;  3T5M A;  1DIK A;  1JDB C;  3C8O A;  5F5X A;  1CX8 A;  4IIY A;  2JBJ A;  1KBL A;  2YJV A;  2EZA A;  3SJF A;  3BXM A;  1DE4 C;  4NGP A;  4TJV A;  2C5Q A;  4IIX A;  3S9M A;  3IIB A;  3TLE A;  2E28 A;  3EIF A;  1CE8 B;  4P4I A;  3FED A;  3D7D A;  5FD8 A;  4CDJ A;  2B0A A;  4CZ1 A;  1ZYM A;  2HWG A;  4OME A;  2GP4 A;  4OC5 A;  4E94 A;  3BI1 A;  4OC0 A;  3SJE A;  2OLS A;  4MCS A;  4C8F A;  2JBK A;  1CS0 B;  4YN3 A;  4EYS A;  4NGS A;  3I74 A;  1EZA A;  4M8D A;  4OC4 A;  2XEJ A;  4C9V A;  1VBG A;  3D7H A;  3BHX A;  4C84 A;  4P4D A;  3S9L A;  2EZB A;  1VI4 A;  1Q5X A;  4COG A;  4P4J A;  4TWE A;  4C86 A;  1M6V B;  1T36 B;  3K9T A;  2D0P A;  4C8P A;  2HI6 A;  4MCP A;  1GGO A;  4C9E A;  4P44 A;  2PVW A;  5F1Y A;  4CDK A;  4H1H A;  5F9M A;  4W9Y A;  4C9R A; 
#chains in the Genus database with same CATH homology
 3FEC A;  2XEF A;  4LQG A;  2EK8 A;  2XEG A;  4OC1 A;  2C6G A;  3FF3 A;  4X3R A;  3BI0 A;  3SJG A;  3KAS A;  2C6C A;  4OC3 A;  3VTA A;  5IB9 A;  4OC2 A;  2PVV A;  1XF1 A;  5F09 A;  3IWW A;  4MCR A;  2C6P A;  4P45 A;  2OR4 A;  1V6C A;  2XEI A;  5IR2 A;  2EK9 A;  4C9A A;  4C99 A;  4KNG E;  4TJX A;  4MCQ A;  3FEE A;  5ELY A;  4NGQ A;  1Z8L A;  3I6S A;  3RBU A;  4NGT A;  4NGN A;  3D7G A;  5D29 A;  4P4B A;  3SJX A;  4C8C A;  4C9U A;  3S9N A;  4C85 A;  2OOT A;  4P4E A;  3ICU A;  4C8U A;  4JYW A;  4C8T A;  4P4F A;  3D7F A;  2CIJ A;  4NGR A;  4NGM A;  1Y9Z A;  1WVM A;  4C8A A;  4JZ0 A;  1CX8 A;  2JBJ A;  3SJF A;  3BXM A;  1DE4 C;  4NGP A;  4TJV A;  2C5Q A;  3S9M A;  3IIB A;  3EIF A;  4P4I A;  3FED A;  3D7D A;  4CDJ A;  4OME A;  2GP4 A;  4OC5 A;  3BI1 A;  4OC0 A;  3SJE A;  4MCS A;  4C8F A;  2JBK A;  4YN3 A;  4NGS A;  3I74 A;  4OC4 A;  2XEJ A;  4C9V A;  3D7H A;  3BHX A;  4C84 A;  4P4D A;  3S9L A;  4P4J A;  4TWE A;  4C86 A;  3K9T A;  4C8P A;  4MCP A;  4C9E A;  4P44 A;  2PVW A;  4CDK A;  4W9Y A;  4C9R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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