4MHXA

Crystal structure of sulfamidase
Total Genus 167
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
483
structure length
482
Chain Sequence
PRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNELRS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
source organism Homo sapiens
publication title Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.
pubmed doi rcsb
molecule keywords N-sulphoglucosamine sulphohydrolase
total genus 167
structure length 482
sequence length 483
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.10.1.1: N-sulfoglucosamine sulfohydrolase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
A PF16347 DUF4976 Domain of unknown function (DUF4976)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4mhxA01
5C66A 2W5QA 1KHNA 2W5TA 3DYCA 4UPLA 5INHA 4KJGA 3SZYA 1URAA 4UPIA 3NKRA 1AUKA 1KH5A 2ZKTA 3UNYA 4CYSA 3MK0A 4LQYA 3WAVA 3A52A 5LRMA 4NWXA 4KM4A 4LR7A 1ZEBA 1N2LA 4KAVA 1AJDA 3T00A 5KXAA 1AJCA 1SHQA 4GTZA 4N7TA 1Y6VA 4LRFA 4UPKA 5EGHA 5LIAA 1KHKA 5GRRA 1EW8A 2IUCB 3WAWA 3IGYB 4LR9A 2VQRA 2W8DA 5AJ9A 4UOOA 3M8YA 4QAXA 1ALJA 3ED4A 5DLTA 1EW2A 1ALIA 1EW9A 1EQJA 4B56A 4GTXA 1ED9A 5IJSA 3NKMA 1KHJA 3NKNA 4MY4A 5EGEA 4LR8A 3T02A 1ED8A 3BDGB 3Q3QA 1ANJA 2G9YA 4CYRA 3MK2A 3NKPA 3OT9A 1ANIA 1HJKA 1N2KA 2W5RA 1Y7AA 4ZG7A 2GA3A 5L0EA 4GTWA 1ALKA 3SZZA 3NVLA 1ZEFA 1AJAA 1ELZA 4UPHA 3T01A 4FDIA 5LQQA 4UORA 3WBHA 2GLQA 3B5QA 2XRGA 4KJDA 1E3CP 2IFYA 1KH9A 5GOVA 2ANHA 4LRDA 2W5VA 2GSUA 1FSUA 3MK1A 5L0BA 3M8ZA 3KD8A 4LRCA 1KHLA 4LRAA 1KH7A 2RH6A 1KH4A 3WAXA 5HRTA 4KAYA 3NKQA 4ZG6A 3NKOA 1ZEDA 1ELXA 1SHNA 1B8JA 4MHXA 5K4PA 1ALHA 3BDHA 2GSNA 4LR2A 1P49A 4YR1A 3TG0A 1HQAA 2XR9A 5L0KA 1EJJA 3WAYA 4CXSA 4CXKA 2X98A 4ZGAA 2W5WA 3IGZB 1O98A 4LRBA 4UOPA 1HDHA 4NWJA 5LRNA 1E2SP 5IJQA 1AJBA 1E1ZP 4GTYA 3CMRA 3BDFA 2W8SA 4FDJA 1E33P 3UN2A 1K7HA 3DPCA 4ZG9A 3M7VA 3M8WA 2IUCA 2W5SA 3LXQA 5DLWA 1EI6A 2GSOA 2QZUA 3E2DA 3UN5A 2D1GA 3IDDA 1O99A 4CXUA 2W5XA 3TWZA 4LREA 3TX0A 5TJ3A 3UO0A 1ELYA 3BDGA 4MIVA 1URBA 3UN3A 5DLVA 4TN0A
chains in the Genus database with same CATH superfamily
5C66A 2W5QA 1KHNA 2W5TA 3DYCA 4UPLA 5INHA 4KJGA 3SZYA 1URAA 4UPIA 3NKRA 1AUKA 1KH5A 2ZKTA 3UNYA 4CYSA 3MK0A 4LQYA 3WAVA 3A52A 5LRMA 4NWXA 4KM4A 4LR7A 1ZEBA 1N2LA 4KAVA 1AJDA 3T00A 5KXAA 1AJCA 1SHQA 4GTZA 4N7TA 1Y6VA 4LRFA 4UPKA 5EGHA 5LIAA 1KHKA 5GRRA 1EW8A 2IUCB 3WAWA 3IGYB 4LR9A 2VQRA 2W8DA 5AJ9A 4UOOA 3M8YA 4QAXA 1ALJA 3ED4A 5DLTA 1EW2A 1ALIA 1EW9A 1EQJA 4B56A 4GTXA 1ED9A 5IJSA 3NKMA 1KHJA 3NKNA 4MY4A 5EGEA 4LR8A 3T02A 1ED8A 3BDGB 3Q3QA 1ANJA 2G9YA 4CYRA 3MK2A 3NKPA 3OT9A 1ANIA 1HJKA 1N2KA 2W5RA 1Y7AA 4ZG7A 2GA3A 5L0EA 4GTWA 1ALKA 3SZZA 3NVLA 1ZEFA 1AJAA 1ELZA 4UPHA 3T01A 4FDIA 5LQQA 4UORA 3WBHA 2GLQA 3B5QA 2XRGA 4KJDA 1E3CP 2IFYA 1KH9A 5GOVA 2ANHA 4LRDA 2W5VA 2GSUA 1FSUA 3MK1A 5L0BA 3M8ZA 3KD8A 4LRCA 1KHLA 4LRAA 1KH7A 2RH6A 1KH4A 3WAXA 5HRTA 4KAYA 3NKQA 4ZG6A 3NKOA 1ZEDA 1ELXA 1SHNA 1B8JA 4MHXA 5K4PA 1ALHA 3BDHA 2GSNA 4LR2A 1P49A 4YR1A 3TG0A 1HQAA 2XR9A 5L0KA 1EJJA 3WAYA 4CXSA 4CXKA 2X98A 4ZGAA 2W5WA 3IGZB 1O98A 4LRBA 4UOPA 1HDHA 4NWJA 5LRNA 1E2SP 5IJQA 1AJBA 1E1ZP 4GTYA 3CMRA 3BDFA 2W8SA 4FDJA 1E33P 3UN2A 1K7HA 3DPCA 4ZG9A 3M7VA 3M8WA 2IUCA 2W5SA 3LXQA 5DLWA 1EI6A 2GSOA 2QZUA 3E2DA 3UN5A 2D1GA 3IDDA 1O99A 4CXUA 2W5XA 3TWZA 4LREA 3TX0A 5TJ3A 3UO0A 1ELYA 3BDGA 4MIVA 1URBA 3UN3A 5DLVA 4TN0A
chains in the Genus database with same CATH topology
5C66A 2W5QA 1KHNA 2W5TA 3DYCA 4UPLA 5INHA 4KJGA 3SZYA 1URAA 4UPIA 3NKRA 1AUKA 1KH5A 2ZKTA 3UNYA 4CYSA 3MK0A 4LQYA 3WAVA 3A52A 5LRMA 4NWXA 4KM4A 4LR7A 1ZEBA 1N2LA 4KAVA 1AJDA 3T00A 5KXAA 1AJCA 1SHQA 4GTZA 4N7TA 1Y6VA 4LRFA 4UPKA 5EGHA 5LIAA 1KHKA 5GRRA 1EW8A 2IUCB 3WAWA 3IGYB 4LR9A 2VQRA 2W8DA 5AJ9A 4UOOA 3M8YA 4QAXA 1ALJA 3ED4A 5DLTA 1EW2A 1ALIA 1EW9A 1EQJA 4B56A 4GTXA 1ED9A 5IJSA 3NKMA 1KHJA 3NKNA 4MY4A 5EGEA 4LR8A 3T02A 1ED8A 3BDGB 3Q3QA 1ANJA 2G9YA 4CYRA 3MK2A 3NKPA 3OT9A 1ANIA 1HJKA 1N2KA 2W5RA 1Y7AA 4ZG7A 2GA3A 5L0EA 4GTWA 1ALKA 3SZZA 3NVLA 1ZEFA 1AJAA 1ELZA 4UPHA 3T01A 4FDIA 5LQQA 4UORA 3WBHA 2GLQA 3B5QA 2XRGA 4KJDA 1E3CP 2IFYA 1KH9A 5GOVA 2ANHA 4LRDA 2W5VA 2GSUA 1FSUA 3MK1A 5L0BA 3M8ZA 3KD8A 4LRCA 1KHLA 4LRAA 1KH7A 2RH6A 1KH4A 3WAXA 5HRTA 4KAYA 3NKQA 4ZG6A 3NKOA 1ZEDA 1ELXA 1SHNA 1B8JA 4MHXA 5K4PA 1ALHA 3BDHA 2GSNA 4LR2A 1P49A 4YR1A 3TG0A 1HQAA 2XR9A 5L0KA 1EJJA 3WAYA 4CXSA 4CXKA 2X98A 4ZGAA 2W5WA 3IGZB 1O98A 4LRBA 4UOPA 1HDHA 4NWJA 5LRNA 1E2SP 5IJQA 1AJBA 1E1ZP 4GTYA 3CMRA 3BDFA 2W8SA 4FDJA 1E33P 3UN2A 1K7HA 3DPCA 4ZG9A 3M7VA 3M8WA 2IUCA 2W5SA 3LXQA 5DLWA 1EI6A 2GSOA 2QZUA 3E2DA 3UN5A 2D1GA 3IDDA 1O99A 4CXUA 2W5XA 3TWZA 4LREA 3TX0A 5TJ3A 3UO0A 1ELYA 3BDGA 4MIVA 1URBA 3UN3A 5DLVA 4TN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C66 A;  2W5Q A;  1KHN A;  2W5T A;  3DYC A;  4UPL A;  5INH A;  4KJG A;  3SZY A;  1URA A;  4UPI A;  3NKR A;  1AUK A;  1KH5 A;  2ZKT A;  3UNY A;  4CYS A;  3MK0 A;  4LQY A;  3WAV A;  3A52 A;  5LRM A;  4NWX A;  4KM4 A;  4LR7 A;  1ZEB A;  1N2L A;  4KAV A;  1AJD A;  3T00 A;  5KXA A;  1AJC A;  1SHQ A;  4GTZ A;  4N7T A;  1Y6V A;  4LRF A;  4UPK A;  5EGH A;  5LIA A;  1KHK A;  5GRR A;  1EW8 A;  2IUC B;  3WAW A;  3IGY B;  4LR9 A;  2VQR A;  2W8D A;  5AJ9 A;  4UOO A;  3M8Y A;  4QAX A;  1ALJ A;  3ED4 A;  5DLT A;  1EW2 A;  1ALI A;  1EW9 A;  1EQJ A;  4B56 A;  4GTX A;  1ED9 A;  5IJS A;  3NKM A;  1KHJ A;  3NKN A;  4MY4 A;  5EGE A;  4LR8 A;  3T02 A;  1ED8 A;  3BDG B;  3Q3Q A;  1ANJ A;  2G9Y A;  4CYR A;  3MK2 A;  3NKP A;  3OT9 A;  1ANI A;  1HJK A;  1N2K A;  2W5R A;  1Y7A A;  4ZG7 A;  2GA3 A;  5L0E A;  4GTW A;  1ALK A;  3SZZ A;  3NVL A;  1ZEF A;  1AJA A;  1ELZ A;  4UPH A;  3T01 A;  4FDI A;  5LQQ A;  4UOR A;  3WBH A;  2GLQ A;  3B5Q A;  2XRG A;  4KJD A;  1E3C P;  2IFY A;  1KH9 A;  5GOV A;  2ANH A;  4LRD A;  2W5V A;  2GSU A;  1FSU A;  3MK1 A;  5L0B A;  3M8Z A;  3KD8 A;  4LRC A;  1KHL A;  4LRA A;  1KH7 A;  2RH6 A;  1KH4 A;  3WAX A;  5HRT A;  4KAY A;  3NKQ A;  4ZG6 A;  3NKO A;  1ZED A;  1ELX A;  1SHN A;  1B8J A;  4MHX A;  5K4P A;  1ALH A;  3BDH A;  2GSN A;  4LR2 A;  1P49 A;  4YR1 A;  3TG0 A;  1HQA A;  2XR9 A;  5L0K A;  1EJJ A;  3WAY A;  4CXS A;  4CXK A;  2X98 A;  4ZGA A;  2W5W A;  3IGZ B;  1O98 A;  4LRB A;  4UOP A;  1HDH A;  4NWJ A;  5LRN A;  1E2S P;  5IJQ A;  1AJB A;  1E1Z P;  4GTY A;  3CMR A;  3BDF A;  2W8S A;  4FDJ A;  1E33 P;  3UN2 A;  1K7H A;  3DPC A;  4ZG9 A;  3M7V A;  3M8W A;  2IUC A;  2W5S A;  3LXQ A;  5DLW A;  1EI6 A;  2GSO A;  2QZU A;  3E2D A;  3UN5 A;  2D1G A;  3IDD A;  1O99 A;  4CXU A;  2W5X A;  3TWZ A;  4LRE A;  3TX0 A;  5TJ3 A;  3UO0 A;  1ELY A;  3BDG A;  4MIV A;  1URB A;  3UN3 A;  5DLV A;  4TN0 A; 
#chains in the Genus database with same CATH topology
 5C66 A;  2W5Q A;  1KHN A;  2W5T A;  3DYC A;  4UPL A;  5INH A;  4KJG A;  3SZY A;  1URA A;  4UPI A;  3NKR A;  1AUK A;  1KH5 A;  2ZKT A;  3UNY A;  4CYS A;  3MK0 A;  4LQY A;  3WAV A;  3A52 A;  5LRM A;  4NWX A;  4KM4 A;  4LR7 A;  1ZEB A;  1N2L A;  4KAV A;  1AJD A;  3T00 A;  5KXA A;  1AJC A;  1SHQ A;  4GTZ A;  4N7T A;  1Y6V A;  4LRF A;  4UPK A;  5EGH A;  5LIA A;  1KHK A;  5GRR A;  1EW8 A;  2IUC B;  3WAW A;  3IGY B;  4LR9 A;  2VQR A;  2W8D A;  5AJ9 A;  4UOO A;  3M8Y A;  4QAX A;  1ALJ A;  3ED4 A;  5DLT A;  1EW2 A;  1ALI A;  1EW9 A;  1EQJ A;  4B56 A;  4GTX A;  1ED9 A;  5IJS A;  3NKM A;  1KHJ A;  3NKN A;  4MY4 A;  5EGE A;  4LR8 A;  3T02 A;  1ED8 A;  3BDG B;  3Q3Q A;  1ANJ A;  2G9Y A;  4CYR A;  3MK2 A;  3NKP A;  3OT9 A;  1ANI A;  1HJK A;  1N2K A;  2W5R A;  1Y7A A;  4ZG7 A;  2GA3 A;  5L0E A;  4GTW A;  1ALK A;  3SZZ A;  3NVL A;  1ZEF A;  1AJA A;  1ELZ A;  4UPH A;  3T01 A;  4FDI A;  5LQQ A;  4UOR A;  3WBH A;  2GLQ A;  3B5Q A;  2XRG A;  4KJD A;  1E3C P;  2IFY A;  1KH9 A;  5GOV A;  2ANH A;  4LRD A;  2W5V A;  2GSU A;  1FSU A;  3MK1 A;  5L0B A;  3M8Z A;  3KD8 A;  4LRC A;  1KHL A;  4LRA A;  1KH7 A;  2RH6 A;  1KH4 A;  3WAX A;  5HRT A;  4KAY A;  3NKQ A;  4ZG6 A;  3NKO A;  1ZED A;  1ELX A;  1SHN A;  1B8J A;  4MHX A;  5K4P A;  1ALH A;  3BDH A;  2GSN A;  4LR2 A;  1P49 A;  4YR1 A;  3TG0 A;  1HQA A;  2XR9 A;  5L0K A;  1EJJ A;  3WAY A;  4CXS A;  4CXK A;  2X98 A;  4ZGA A;  2W5W A;  3IGZ B;  1O98 A;  4LRB A;  4UOP A;  1HDH A;  4NWJ A;  5LRN A;  1E2S P;  5IJQ A;  1AJB A;  1E1Z P;  4GTY A;  3CMR A;  3BDF A;  2W8S A;  4FDJ A;  1E33 P;  3UN2 A;  1K7H A;  3DPC A;  4ZG9 A;  3M7V A;  3M8W A;  2IUC A;  2W5S A;  3LXQ A;  5DLW A;  1EI6 A;  2GSO A;  2QZU A;  3E2D A;  3UN5 A;  2D1G A;  3IDD A;  1O99 A;  4CXU A;  2W5X A;  3TWZ A;  4LRE A;  3TX0 A;  5TJ3 A;  3UO0 A;  1ELY A;  3BDG A;  4MIV A;  1URB A;  3UN3 A;  5DLV A;  4TN0 A; 
#chains in the Genus database with same CATH homology
 5C66 A;  2W5Q A;  1KHN A;  2W5T A;  3DYC A;  4UPL A;  5INH A;  4KJG A;  3SZY A;  1URA A;  4UPI A;  3NKR A;  1AUK A;  1KH5 A;  2ZKT A;  3UNY A;  4CYS A;  3MK0 A;  4LQY A;  3WAV A;  3A52 A;  5LRM A;  4NWX A;  4KM4 A;  4LR7 A;  1ZEB A;  1N2L A;  4KAV A;  1AJD A;  3T00 A;  5KXA A;  1AJC A;  1SHQ A;  4GTZ A;  4N7T A;  1Y6V A;  4LRF A;  4UPK A;  5EGH A;  5LIA A;  1KHK A;  5GRR A;  1EW8 A;  2IUC B;  3WAW A;  3IGY B;  4LR9 A;  2VQR A;  2W8D A;  5AJ9 A;  4UOO A;  3M8Y A;  4QAX A;  1ALJ A;  3ED4 A;  5DLT A;  1EW2 A;  1ALI A;  1EW9 A;  1EQJ A;  4B56 A;  4GTX A;  1ED9 A;  5IJS A;  3NKM A;  1KHJ A;  3NKN A;  4MY4 A;  5EGE A;  4LR8 A;  3T02 A;  1ED8 A;  3BDG B;  3Q3Q A;  1ANJ A;  2G9Y A;  4CYR A;  3MK2 A;  3NKP A;  3OT9 A;  1ANI A;  1HJK A;  1N2K A;  2W5R A;  1Y7A A;  4ZG7 A;  2GA3 A;  5L0E A;  4GTW A;  1ALK A;  3SZZ A;  3NVL A;  1ZEF A;  1AJA A;  1ELZ A;  4UPH A;  3T01 A;  4FDI A;  5LQQ A;  4UOR A;  3WBH A;  2GLQ A;  3B5Q A;  2XRG A;  4KJD A;  1E3C P;  2IFY A;  1KH9 A;  5GOV A;  2ANH A;  4LRD A;  2W5V A;  2GSU A;  1FSU A;  3MK1 A;  5L0B A;  3M8Z A;  3KD8 A;  4LRC A;  1KHL A;  4LRA A;  1KH7 A;  2RH6 A;  1KH4 A;  3WAX A;  5HRT A;  4KAY A;  3NKQ A;  4ZG6 A;  3NKO A;  1ZED A;  1ELX A;  1SHN A;  1B8J A;  4MHX A;  5K4P A;  1ALH A;  3BDH A;  2GSN A;  4LR2 A;  1P49 A;  4YR1 A;  3TG0 A;  1HQA A;  2XR9 A;  5L0K A;  1EJJ A;  3WAY A;  4CXS A;  4CXK A;  2X98 A;  4ZGA A;  2W5W A;  3IGZ B;  1O98 A;  4LRB A;  4UOP A;  1HDH A;  4NWJ A;  5LRN A;  1E2S P;  5IJQ A;  1AJB A;  1E1Z P;  4GTY A;  3CMR A;  3BDF A;  2W8S A;  4FDJ A;  1E33 P;  3UN2 A;  1K7H A;  3DPC A;  4ZG9 A;  3M7V A;  3M8W A;  2IUC A;  2W5S A;  3LXQ A;  5DLW A;  1EI6 A;  2GSO A;  2QZU A;  3E2D A;  3UN5 A;  2D1G A;  3IDD A;  1O99 A;  4CXU A;  2W5X A;  3TWZ A;  4LRE A;  3TX0 A;  5TJ3 A;  3UO0 A;  1ELY A;  3BDG A;  4MIV A;  1URB A;  3UN3 A;  5DLV A;  4TN0 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...