4C8U | Genus

Total Genus 33

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	33
sequence length	152
structure length	146
Chain Sequence	ETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATISAEGEIVQMHPLGLCDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Ligase
source organism	Xenopus (silurana) tropicalis
publication title	Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. pubmed doi rcsb
molecule keywords	E3 UBIQUITIN-PROTEIN LIGASE ZNRF3
total genus	33
structure length	146
sequence length	152
chains with identical sequence	B
ec nomenclature	ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date	2013-10-01

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF18212	ZNRF_3_ecto	ZNRF-3 Ectodomain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.50.30.30	Alpha Beta	3-Layer(bba) Sandwich	Glucose Oxidase; domain 1	Glucose Oxidase; domain 1	4c8uA00

5D29A 4P45A 4C9RA 2XEJA 1DE4C 3FF3A 3I74A 2OR4A 3D7GA 4NGNA 2XEIA 4C8AA 1Y9ZA 3S9MA 3IIBA 2PVVA 4C9EA 4MCQA 1CX8A 4OMEA 2XEFA 4P4EA 2C6CA 1XF1A 4NGTA 4P4DA 4TWEA 2JBKA 4KNGE 3FEEA 4MCPA 2EK8A 3ICUA 4OC4A 2EK9A 4JYWA 2C6GA 3SJFA 3S9LA 4NGPA 3FECA 4X3RA 3S9NA 4C8PA 2C6PA 4W9YA 4TJVA 4NGMA 4C86A 4C9VA 3D7HA 4C8TA 4CDJA 4C9UA 4P4IA 3RBUA 3SJGA 5ELYA 3BHXA 4P4FA 4C8FA 3D7DA 4YN3A 2XEGA 4OC1A 1V6CA 3BI1A 4NGQA 3IWWA 2OOTA 4OC0A 4C9AA 3BXMA 4P44A 4P4BA 3I6SA 4TJXA 2PVWA 4C84A 4MCRA 4CDKA 3VTAA 3SJEA 1WVMA 3D7FA 3KASA 4MCSA 1Z8LA 2CIJA 4OC2A 4P4JA 4OC3A 3FEDA 5F09A 4C99A 4JZ0A 4LQGA 5IB9A 3BI0A 4NGRA 3EIFA 4NGSA 4C8UA 4C8CA 2JBJA 3SJXA 4OC5A 4C85A
chains in the Genus database with same CATH superfamily

4IIXA 5D29A 4P45A 4C9RA 1VBHA 2XEJA 1DE4C 3FF3A 3I74A 1EZAA 3EZBA 1BXRB 2AUMA 2OR4A 1KBLA 3D7GA 2B0AA 2XEIA 4NGNA 4C8AA 1M6VB 1C3OB 1Y9ZA 2HROA 3T05A 1T36B 3S9MA 3IIBA 2PVVA 4C9EA 2AUNA 1CX8A 4MCQA 2HI6A 3T0TA 4OMEA 2XEFA 4P4EA 2PCNA 3TLEA 2EZBA 1NBWA 2OLSA 3G23A 4MJXA 2C6CA 3TLGB 1XF1A 4NGTA 4JVOA 4MI1A 2HWGA 2FM4A 3EZAA 1VBGA 4P4DA 4TWEA 2JBKA 3K9TA 4KNGE 5F5XA 3FEEA 4IIYA 4MCPA 1C30B 2EK8A 2GP4A 5F9MA 3TLGA 3TLZA 3T07A 4M8DA 3EZEA 3ICUA 4OC4A 2EK9A 4JYWA 4CZ1A 2C6GA 3TLBA 3SJFA 3S9LA 2C5QA 3NOJA 4NGPA 5K99A 4H1HA 3FECA 4X3RA 3S9NA 4C8PA 2MP0A 2C6PA 2X0SA 4TJVA 4W9YA 4COGA 4NGMA 3C8OA 3KRVA 3TLYA 4J0NA 4C86A 4E94A 1ZRSA 1KEEB 4C9VA 3T5MA 1EZBA 3D7HA 4C8TA 4CDJA 2YJVA 4C9UA 4P4IA 3RBUA 4EYSA 3SJGA 2D0PA 3GJZA 1JDEA 1CE8B 5ELYA 4CO9A 3BHXA 2E28A 4P4FA 4C8FA 3D7DA 4YN3A 2XEGA 4OC1A 3SR3A 1V6CA 3BI1A 4E5SA 4NGQA 3IWWA 2OOTA 4OC0A 4C9AA 3BXMA 4P44A 4P4BA 3I6SA 1DIKA 2EZAA 4TJXA 2PVWA 2D0OA 2YJTA 4MCRA 4C84A 1KC7A 1Q5XA 1NXJA 5FD8A 4CDKA 3VTAA 1CS0B 3SJEA 1WVMA 1A9XB 3TYXA 1J3LA 3D7FA 3KASA 2R82A 5F1YA 2EZCA 4INJA 5JVLA 4MCSA 1Z8LA 2CIJA 4OC2A 4P4JA 5IR2A 1GGOA 4OC3A 1ZYMA 5JYBA 3FEDA 1ZL0A 3TLCA 5F09A 1JDBC 4C99A 4JZ0A 4LQGA 5IB9A 3BI0A 4NGRA 3EIFA 4NGSA 4C8UA 4C8CA 1VI4A 3U1BA 3K4IA 4COBA 2JBJA 3SJXA 3TLAA 1R61A 4OC5A 4C85A 2DIKA
chains in the Genus database with same CATH topology

5D29A 4P45A 4C9RA 2XEJA 1DE4C 3FF3A 3I74A 2OR4A 3D7GA 4NGNA 2XEIA 4C8AA 1Y9ZA 3S9MA 3IIBA 2PVVA 4C9EA 4MCQA 1CX8A 4OMEA 2XEFA 4P4EA 2C6CA 1XF1A 4NGTA 4P4DA 4TWEA 2JBKA 3K9TA 4KNGE 3FEEA 4MCPA 2EK8A 2GP4A 3ICUA 4OC4A 2EK9A 4JYWA 2C6GA 3SJFA 3S9LA 2C5QA 4NGPA 3FECA 4X3RA 3S9NA 4C8PA 2C6PA 4W9YA 4TJVA 4NGMA 4C86A 4C9VA 3D7HA 4C8TA 4CDJA 4C9UA 4P4IA 3RBUA 3SJGA 5ELYA 3BHXA 4P4FA 4C8FA 3D7DA 4YN3A 2XEGA 4OC1A 1V6CA 3BI1A 4NGQA 3IWWA 2OOTA 4OC0A 4C9AA 3BXMA 4P44A 4P4BA 3I6SA 4TJXA 2PVWA 4C84A 4MCRA 4CDKA 3VTAA 3SJEA 1WVMA 3D7FA 3KASA 4MCSA 1Z8LA 2CIJA 4OC2A 4P4JA 5IR2A 4OC3A 3FEDA 5F09A 4C99A 4JZ0A 4LQGA 5IB9A 3BI0A 4NGRA 3EIFA 4NGSA 4C8UA 4C8CA 2JBJA 3SJXA 4OC5A 4C85A
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 5D29 A;  4P45 A;  4C9R A;  2XEJ A;  1DE4 C;  3FF3 A;  3I74 A;  2OR4 A;  3D7G A;  4NGN A;  2XEI A;  4C8A A;  1Y9Z A;  3S9M A;  3IIB A;  2PVV A;  4C9E A;  4MCQ A;  1CX8 A;  4OME A;  2XEF A;  4P4E A;  2C6C A;  1XF1 A;  4NGT A;  4P4D A;  4TWE A;  2JBK A;  4KNG E;  3FEE A;  4MCP A;  2EK8 A;  3ICU A;  4OC4 A;  2EK9 A;  4JYW A;  2C6G A;  3SJF A;  3S9L A;  4NGP A;  3FEC A;  4X3R A;  3S9N A;  4C8P A;  2C6P A;  4W9Y A;  4TJV A;  4NGM A;  4C86 A;  4C9V A;  3D7H A;  4C8T A;  4CDJ A;  4C9U A;  4P4I A;  3RBU A;  3SJG A;  5ELY A;  3BHX A;  4P4F A;  4C8F A;  3D7D A;  4YN3 A;  2XEG A;  4OC1 A;  1V6C A;  3BI1 A;  4NGQ A;  3IWW A;  2OOT A;  4OC0 A;  4C9A A;  3BXM A;  4P44 A;  4P4B A;  3I6S A;  4TJX A;  2PVW A;  4C84 A;  4MCR A;  4CDK A;  3VTA A;  3SJE A;  1WVM A;  3D7F A;  3KAS A;  4MCS A;  1Z8L A;  2CIJ A;  4OC2 A;  4P4J A;  4OC3 A;  3FED A;  5F09 A;  4C99 A;  4JZ0 A;  4LQG A;  5IB9 A;  3BI0 A;  4NGR A;  3EIF A;  4NGS A;  4C8U A;  4C8C A;  2JBJ A;  3SJX A;  4OC5 A;  4C85 A; 
#chains in the Genus database with same CATH topology
 4IIX A;  5D29 A;  4P45 A;  4C9R A;  1VBH A;  2XEJ A;  1DE4 C;  3FF3 A;  3I74 A;  1EZA A;  3EZB A;  1BXR B;  2AUM A;  2OR4 A;  1KBL A;  3D7G A;  2B0A A;  2XEI A;  4NGN A;  4C8A A;  1M6V B;  1C3O B;  1Y9Z A;  2HRO A;  3T05 A;  1T36 B;  3S9M A;  3IIB A;  2PVV A;  4C9E A;  2AUN A;  1CX8 A;  4MCQ A;  2HI6 A;  3T0T A;  4OME A;  2XEF A;  4P4E A;  2PCN A;  3TLE A;  2EZB A;  1NBW A;  2OLS A;  3G23 A;  4MJX A;  2C6C A;  3TLG B;  1XF1 A;  4NGT A;  4JVO A;  4MI1 A;  2HWG A;  2FM4 A;  3EZA A;  1VBG A;  4P4D A;  4TWE A;  2JBK A;  3K9T A;  4KNG E;  5F5X A;  3FEE A;  4IIY A;  4MCP A;  1C30 B;  2EK8 A;  2GP4 A;  5F9M A;  3TLG A;  3TLZ A;  3T07 A;  4M8D A;  3EZE A;  3ICU A;  4OC4 A;  2EK9 A;  4JYW A;  4CZ1 A;  2C6G A;  3TLB A;  3SJF A;  3S9L A;  2C5Q A;  3NOJ A;  4NGP A;  5K99 A;  4H1H A;  3FEC A;  4X3R A;  3S9N A;  4C8P A;  2MP0 A;  2C6P A;  2X0S A;  4TJV A;  4W9Y A;  4COG A;  4NGM A;  3C8O A;  3KRV A;  3TLY A;  4J0N A;  4C86 A;  4E94 A;  1ZRS A;  1KEE B;  4C9V A;  3T5M A;  1EZB A;  3D7H A;  4C8T A;  4CDJ A;  2YJV A;  4C9U A;  4P4I A;  3RBU A;  4EYS A;  3SJG A;  2D0P A;  3GJZ A;  1JDE A;  1CE8 B;  5ELY A;  4CO9 A;  3BHX A;  2E28 A;  4P4F A;  4C8F A;  3D7D A;  4YN3 A;  2XEG A;  4OC1 A;  3SR3 A;  1V6C A;  3BI1 A;  4E5S A;  4NGQ A;  3IWW A;  2OOT A;  4OC0 A;  4C9A A;  3BXM A;  4P44 A;  4P4B A;  3I6S A;  1DIK A;  2EZA A;  4TJX A;  2PVW A;  2D0O A;  2YJT A;  4MCR A;  4C84 A;  1KC7 A;  1Q5X A;  1NXJ A;  5FD8 A;  4CDK A;  3VTA A;  1CS0 B;  3SJE A;  1WVM A;  1A9X B;  3TYX A;  1J3L A;  3D7F A;  3KAS A;  2R82 A;  5F1Y A;  2EZC A;  4INJ A;  5JVL A;  4MCS A;  1Z8L A;  2CIJ A;  4OC2 A;  4P4J A;  5IR2 A;  1GGO A;  4OC3 A;  1ZYM A;  5JYB A;  3FED A;  1ZL0 A;  3TLC A;  5F09 A;  1JDB C;  4C99 A;  4JZ0 A;  4LQG A;  5IB9 A;  3BI0 A;  4NGR A;  3EIF A;  4NGS A;  4C8U A;  4C8C A;  1VI4 A;  3U1B A;  3K4I A;  4COB A;  2JBJ A;  3SJX A;  3TLA A;  1R61 A;  4OC5 A;  4C85 A;  2DIK A; 
#chains in the Genus database with same CATH homology
 5D29 A;  4P45 A;  4C9R A;  2XEJ A;  1DE4 C;  3FF3 A;  3I74 A;  2OR4 A;  3D7G A;  4NGN A;  2XEI A;  4C8A A;  1Y9Z A;  3S9M A;  3IIB A;  2PVV A;  4C9E A;  4MCQ A;  1CX8 A;  4OME A;  2XEF A;  4P4E A;  2C6C A;  1XF1 A;  4NGT A;  4P4D A;  4TWE A;  2JBK A;  3K9T A;  4KNG E;  3FEE A;  4MCP A;  2EK8 A;  2GP4 A;  3ICU A;  4OC4 A;  2EK9 A;  4JYW A;  2C6G A;  3SJF A;  3S9L A;  2C5Q A;  4NGP A;  3FEC A;  4X3R A;  3S9N A;  4C8P A;  2C6P A;  4W9Y A;  4TJV A;  4NGM A;  4C86 A;  4C9V A;  3D7H A;  4C8T A;  4CDJ A;  4C9U A;  4P4I A;  3RBU A;  3SJG A;  5ELY A;  3BHX A;  4P4F A;  4C8F A;  3D7D A;  4YN3 A;  2XEG A;  4OC1 A;  1V6C A;  3BI1 A;  4NGQ A;  3IWW A;  2OOT A;  4OC0 A;  4C9A A;  3BXM A;  4P44 A;  4P4B A;  3I6S A;  4TJX A;  2PVW A;  4C84 A;  4MCR A;  4CDK A;  3VTA A;  3SJE A;  1WVM A;  3D7F A;  3KAS A;  4MCS A;  1Z8L A;  2CIJ A;  4OC2 A;  4P4J A;  5IR2 A;  4OC3 A;  3FED A;  5F09 A;  4C99 A;  4JZ0 A;  4LQG A;  5IB9 A;  3BI0 A;  4NGR A;  3EIF A;  4NGS A;  4C8U A;  4C8C A;  2JBJ A;  3SJX A;  4OC5 A;  4C85 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4C8UA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations