4KNGE

Crystal structure of human lgr5-rspo1-rnf43
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
149
structure length
149
Chain Sequence
QKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis of R-spondin recognition by LGR5 and RNF43.
pubmed doi rcsb
molecule tags Signaling protein, membrane protein
source organism Homo sapiens
molecule keywords Leucine-rich repeat-containing G-protein coupled receptor 5
total genus 32
structure length 149
sequence length 149
chains with identical sequence F
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2013-05-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF18212 ZNRF_3_ecto ZNRF-3 Ectodomain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.30.30 Alpha Beta 3-Layer(bba) Sandwich Glucose Oxidase; domain 1 Glucose Oxidase; domain 1 4kngE00
4C8AA 4KNGE 3FEDA 4TWEA 2XEIA 3D7HA 4OC3A 4P4FA 4W9YA 1Z8LA 4JZ0A 4C9UA 2CIJA 4TJXA 2EK9A 4MCRA 4OC0A 3SJXA 4LQGA 2XEFA 4TJVA 5IB9A 5F09A 4C9EA 4C99A 4OC5A 4P4IA 5D29A 3FF3A 3I74A 2OR4A 3ICUA 3S9NA 4NGQA 4P44A 2XEJA 3EIFA 3S9MA 3BI1A 2C6GA 4MCSA 4NGPA 3VTAA 4NGNA 4NGMA 3S9LA 2OOTA 3I6SA 4MCPA 4CDJA 3BXMA 3SJGA 4C8CA 3BI0A 3SJEA 3FECA 5ELYA 4NGSA 4NGTA 4MCQA 3D7DA 4C8UA 3FEEA 4C84A 4OMEA 2C6CA 2JBKA 4X3RA 4CDKA 3IIBA 4OC2A 4C9VA 1V6CA 1WVMA 4P4EA 2JBJA 4NGRA 1XF1A 3RBUA 2PVWA 4C8FA 4C9RA 2EK8A 4OC4A 3IWWA 4C9AA 4P45A 1Y9ZA 4P4BA 4C86A 3BHXA 2XEGA 4OC1A 4C8TA 4P4DA 3D7FA 2C6PA 3KASA 4JYWA 3SJFA 4C8PA 3D7GA 4C85A 4YN3A 1DE4C 2PVVA 4P4JA 1CX8A
chains in the Genus database with same CATH superfamily
3GJZA 2AUMA 4C8AA 1ZL0A 4KNGE 3FEDA 1GGOA 4TWEA 5JYBA 2XEIA 3D7HA 4OC3A 4P4FA 4W9YA 2AUNA 3KRVA 2X0SA 1Z8LA 2FM4A 2D0PA 4MI1A 4JZ0A 3TLBA 4MJXA 1ZYMA 2EZCA 4E5SA 4C9UA 2CIJA 4TJXA 1VI4A 2EK9A 4MCRA 4OC0A 3SJXA 3EZAA 4LQGA 2XEFA 1JDBC 3TLAA 1A9XB 2B0AA 1VBHA 1ZRSA 4TJVA 4CO9A 5IB9A 5F09A 1EZAA 4C9EA 3T07A 4C99A 4OC5A 4P4IA 3TLEA 5D29A 3C8OA 3FF3A 3I74A 5JVLA 2YJVA 4J0NA 2OR4A 3ICUA 3S9NA 4COBA 1CS0B 2EZBA 4NGQA 4P44A 4IIXA 5F9MA 2XEJA 3EIFA 3S9MA 3BI1A 4INJA 1JDEA 2C6GA 1M6VB 4MCSA 4NGPA 4JVOA 3VTAA 2D0OA 3T5MA 1VBGA 1C3OB 4IIYA 4NGNA 4NGMA 3S9LA 4M8DA 2OOTA 3I6SA 4MCPA 4CDJA 2HROA 3BXMA 3SJGA 3EZEA 4C8CA 5F5XA 3U1BA 3BI0A 2GP4A 3SJEA 3FECA 5ELYA 4NGSA 4NGTA 4MCQA 3D7DA 4C8UA 3FEEA 2YJTA 1R61A 3EZBA 2E28A 5F1YA 4C84A 2MP0A 4OMEA 2C6CA 1J3LA 2JBKA 5IR2A 4X3RA 4CDKA 3TLGA 3SR3A 2EZAA 3IIBA 4OC2A 4C9VA 1V6CA 1WVMA 1EZBA 4P4EA 2DIKA 3TLGB 2JBJA 3G23A 4NGRA 1XF1A 4H1HA 2R82A 3RBUA 2PVWA 4C8FA 3K4IA 1T36B 2PCNA 1BXRB 4E94A 1KBLA 2HI6A 1NBWA 1NXJA 2EK8A 4C9RA 4OC4A 3TLZA 3IWWA 2OLSA 1C30B 4COGA 1KEEB 4C9AA 4CZ1A 3NOJA 4P45A 1Y9ZA 4P4BA 4C86A 3T05A 3T0TA 3BHXA 1DIKA 2XEGA 1Q5XA 3TLCA 4OC1A 4C8TA 4P4DA 3D7FA 2C6PA 3KASA 4JYWA 3SJFA 4C8PA 3D7GA 4EYSA 2C5QA 3TYXA 4C85A 4YN3A 1CE8B 1DE4C 2PVVA 3K9TA 2HWGA 4P4JA 5FD8A 3TLYA 1KC7A 5K99A 1CX8A
chains in the Genus database with same CATH topology
4C8AA 4KNGE 3FEDA 4TWEA 2XEIA 3D7HA 4OC3A 4P4FA 4W9YA 1Z8LA 4JZ0A 4C9UA 2CIJA 4TJXA 2EK9A 4MCRA 4OC0A 3SJXA 4LQGA 2XEFA 4TJVA 5IB9A 5F09A 4C9EA 4C99A 4OC5A 4P4IA 5D29A 3FF3A 3I74A 2OR4A 3ICUA 3S9NA 4NGQA 4P44A 2XEJA 3EIFA 3S9MA 3BI1A 2C6GA 4MCSA 4NGPA 3VTAA 4NGNA 4NGMA 3S9LA 2OOTA 3I6SA 4MCPA 4CDJA 3BXMA 3SJGA 4C8CA 3BI0A 2GP4A 3SJEA 3FECA 5ELYA 4NGSA 4NGTA 4MCQA 3D7DA 4C8UA 3FEEA 4C84A 4OMEA 2C6CA 2JBKA 5IR2A 4X3RA 4CDKA 3IIBA 4OC2A 4C9VA 1V6CA 1WVMA 4P4EA 2JBJA 4NGRA 1XF1A 3RBUA 2PVWA 4C8FA 4C9RA 2EK8A 4OC4A 3IWWA 4C9AA 4P45A 1Y9ZA 4P4BA 4C86A 3BHXA 2XEGA 4OC1A 4C8TA 4P4DA 3D7FA 2C6PA 3KASA 4JYWA 3SJFA 4C8PA 3D7GA 2C5QA 4C85A 4YN3A 1DE4C 2PVVA 3K9TA 4P4JA 1CX8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C8A A;  4KNG E;  3FED A;  4TWE A;  2XEI A;  3D7H A;  4OC3 A;  4P4F A;  4W9Y A;  1Z8L A;  4JZ0 A;  4C9U A;  2CIJ A;  4TJX A;  2EK9 A;  4MCR A;  4OC0 A;  3SJX A;  4LQG A;  2XEF A;  4TJV A;  5IB9 A;  5F09 A;  4C9E A;  4C99 A;  4OC5 A;  4P4I A;  5D29 A;  3FF3 A;  3I74 A;  2OR4 A;  3ICU A;  3S9N A;  4NGQ A;  4P44 A;  2XEJ A;  3EIF A;  3S9M A;  3BI1 A;  2C6G A;  4MCS A;  4NGP A;  3VTA A;  4NGN A;  4NGM A;  3S9L A;  2OOT A;  3I6S A;  4MCP A;  4CDJ A;  3BXM A;  3SJG A;  4C8C A;  3BI0 A;  3SJE A;  3FEC A;  5ELY A;  4NGS A;  4NGT A;  4MCQ A;  3D7D A;  4C8U A;  3FEE A;  4C84 A;  4OME A;  2C6C A;  2JBK A;  4X3R A;  4CDK A;  3IIB A;  4OC2 A;  4C9V A;  1V6C A;  1WVM A;  4P4E A;  2JBJ A;  4NGR A;  1XF1 A;  3RBU A;  2PVW A;  4C8F A;  4C9R A;  2EK8 A;  4OC4 A;  3IWW A;  4C9A A;  4P45 A;  1Y9Z A;  4P4B A;  4C86 A;  3BHX A;  2XEG A;  4OC1 A;  4C8T A;  4P4D A;  3D7F A;  2C6P A;  3KAS A;  4JYW A;  3SJF A;  4C8P A;  3D7G A;  4C85 A;  4YN3 A;  1DE4 C;  2PVV A;  4P4J A;  1CX8 A; 
#chains in the Genus database with same CATH topology
 3GJZ A;  2AUM A;  4C8A A;  1ZL0 A;  4KNG E;  3FED A;  1GGO A;  4TWE A;  5JYB A;  2XEI A;  3D7H A;  4OC3 A;  4P4F A;  4W9Y A;  2AUN A;  3KRV A;  2X0S A;  1Z8L A;  2FM4 A;  2D0P A;  4MI1 A;  4JZ0 A;  3TLB A;  4MJX A;  1ZYM A;  2EZC A;  4E5S A;  4C9U A;  2CIJ A;  4TJX A;  1VI4 A;  2EK9 A;  4MCR A;  4OC0 A;  3SJX A;  3EZA A;  4LQG A;  2XEF A;  1JDB C;  3TLA A;  1A9X B;  2B0A A;  1VBH A;  1ZRS A;  4TJV A;  4CO9 A;  5IB9 A;  5F09 A;  1EZA A;  4C9E A;  3T07 A;  4C99 A;  4OC5 A;  4P4I A;  3TLE A;  5D29 A;  3C8O A;  3FF3 A;  3I74 A;  5JVL A;  2YJV A;  4J0N A;  2OR4 A;  3ICU A;  3S9N A;  4COB A;  1CS0 B;  2EZB A;  4NGQ A;  4P44 A;  4IIX A;  5F9M A;  2XEJ A;  3EIF A;  3S9M A;  3BI1 A;  4INJ A;  1JDE A;  2C6G A;  1M6V B;  4MCS A;  4NGP A;  4JVO A;  3VTA A;  2D0O A;  3T5M A;  1VBG A;  1C3O B;  4IIY A;  4NGN A;  4NGM A;  3S9L A;  4M8D A;  2OOT A;  3I6S A;  4MCP A;  4CDJ A;  2HRO A;  3BXM A;  3SJG A;  3EZE A;  4C8C A;  5F5X A;  3U1B A;  3BI0 A;  2GP4 A;  3SJE A;  3FEC A;  5ELY A;  4NGS A;  4NGT A;  4MCQ A;  3D7D A;  4C8U A;  3FEE A;  2YJT A;  1R61 A;  3EZB A;  2E28 A;  5F1Y A;  4C84 A;  2MP0 A;  4OME A;  2C6C A;  1J3L A;  2JBK A;  5IR2 A;  4X3R A;  4CDK A;  3TLG A;  3SR3 A;  2EZA A;  3IIB A;  4OC2 A;  4C9V A;  1V6C A;  1WVM A;  1EZB A;  4P4E A;  2DIK A;  3TLG B;  2JBJ A;  3G23 A;  4NGR A;  1XF1 A;  4H1H A;  2R82 A;  3RBU A;  2PVW A;  4C8F A;  3K4I A;  1T36 B;  2PCN A;  1BXR B;  4E94 A;  1KBL A;  2HI6 A;  1NBW A;  1NXJ A;  2EK8 A;  4C9R A;  4OC4 A;  3TLZ A;  3IWW A;  2OLS A;  1C30 B;  4COG A;  1KEE B;  4C9A A;  4CZ1 A;  3NOJ A;  4P45 A;  1Y9Z A;  4P4B A;  4C86 A;  3T05 A;  3T0T A;  3BHX A;  1DIK A;  2XEG A;  1Q5X A;  3TLC A;  4OC1 A;  4C8T A;  4P4D A;  3D7F A;  2C6P A;  3KAS A;  4JYW A;  3SJF A;  4C8P A;  3D7G A;  4EYS A;  2C5Q A;  3TYX A;  4C85 A;  4YN3 A;  1CE8 B;  1DE4 C;  2PVV A;  3K9T A;  2HWG A;  4P4J A;  5FD8 A;  3TLY A;  1KC7 A;  5K99 A;  1CX8 A; 
#chains in the Genus database with same CATH homology
 4C8A A;  4KNG E;  3FED A;  4TWE A;  2XEI A;  3D7H A;  4OC3 A;  4P4F A;  4W9Y A;  1Z8L A;  4JZ0 A;  4C9U A;  2CIJ A;  4TJX A;  2EK9 A;  4MCR A;  4OC0 A;  3SJX A;  4LQG A;  2XEF A;  4TJV A;  5IB9 A;  5F09 A;  4C9E A;  4C99 A;  4OC5 A;  4P4I A;  5D29 A;  3FF3 A;  3I74 A;  2OR4 A;  3ICU A;  3S9N A;  4NGQ A;  4P44 A;  2XEJ A;  3EIF A;  3S9M A;  3BI1 A;  2C6G A;  4MCS A;  4NGP A;  3VTA A;  4NGN A;  4NGM A;  3S9L A;  2OOT A;  3I6S A;  4MCP A;  4CDJ A;  3BXM A;  3SJG A;  4C8C A;  3BI0 A;  2GP4 A;  3SJE A;  3FEC A;  5ELY A;  4NGS A;  4NGT A;  4MCQ A;  3D7D A;  4C8U A;  3FEE A;  4C84 A;  4OME A;  2C6C A;  2JBK A;  5IR2 A;  4X3R A;  4CDK A;  3IIB A;  4OC2 A;  4C9V A;  1V6C A;  1WVM A;  4P4E A;  2JBJ A;  4NGR A;  1XF1 A;  3RBU A;  2PVW A;  4C8F A;  4C9R A;  2EK8 A;  4OC4 A;  3IWW A;  4C9A A;  4P45 A;  1Y9Z A;  4P4B A;  4C86 A;  3BHX A;  2XEG A;  4OC1 A;  4C8T A;  4P4D A;  3D7F A;  2C6P A;  3KAS A;  4JYW A;  3SJF A;  4C8P A;  3D7G A;  2C5Q A;  4C85 A;  4YN3 A;  1DE4 C;  2PVV A;  3K9T A;  4P4J A;  1CX8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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