4MHXA

Crystal structure of sulfamidase
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
483
structure length
482
Chain Sequence
PRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNELRS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords N-sulphoglucosamine sulphohydrolase
publication title Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.
pubmed doi rcsb
source organism Homo sapiens
total genus 167
structure length 482
sequence length 483
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.10.1.1: N-sulfoglucosamine sulfohydrolase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
A PF16347 DUF4976 Domain of unknown function (DUF4976)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4mhxA01
5L0EA 4LR8A 5DLWA 3MK0A 5KXAA 1ANIA 1AJBA 3NKOA 5INHA 3M8ZA 2D1GA 2W8DA 3UO0A 1AJCA 1FSUA 1O99A 1AJDA 4GTXA 4NWJA 4UOOA 4LRBA 1ZEDA 2ANHA 1N2LA 2G9YA 4KJDA 5EGHA 4QAXA 5IJSA 1URBA 2RH6A 4UOPA 4CXUA 4CYRA 4GTWA 2W5RA 5C66A 4GTYA 1EW2A 1ED9A 3DYCA 1KHNA 3MK2A 5GOVA 1KHLA 2GSNA 5HRTA 3B5QA 4UPHA 3Q3QA 4FDIA 5DLVA 1O98A 1E1ZP 2XRGA 5LRNA 3CMRA 4LREA 1EJJA 4NWXA 1KH9A 3WAVA 1ELYA 3M7VA 1HJKA 3UN5A 1SHNA 5GRRA 1AJAA 2QZUA 1EQJA 3OT9A 3A52A 4UPKA 3WBHA 3T02A 2GSUA 4ZGAA 1E33P 1HQAA 1ZEBA 2IUCB 5AJ9A 2IFYA 4UPLA 2W5QA 2GA3A 2W5VA 3T01A 2W5WA 4LQYA 4FDJA 3TWZA 4LR2A 2W5XA 2GSOA 3ED4A 4CXSA 1ALHA 1SHQA 4CYSA 3UN3A 4KJGA 1KHJA 4LR9A 4MHXA 4B56A 2ZKTA 1E3CP 1E2SP 2W5TA 3IDDA 2IUCA 3KD8A 3MK1A 4LRCA 1Y6VA 3E2DA 1ED8A 1N2KA 3IGYB 1ZEFA 4LRDA 1ANJA 3BDFA 4UORA 3M8YA 4KAVA 5IJQA 1URAA 1Y7AA 3SZYA 1ALKA 3WAWA 3BDHA 4ZG7A 1KH7A 5L0BA 1KH4A 3SZZA 3WAYA 3NKMA 1ALIA 2VQRA 2X98A 5L0KA 4GTZA 1EW8A 3NKRA 3NKQA 3UN2A 5LIAA 3BDGB 4ZG6A 4YR1A 1ELXA 1KHKA 1KH5A 4MY4A 1HDHA 4KAYA 1EW9A 3UNYA 4CXKA 2GLQA 3NKNA 4LRFA 3TX0A 5LQQA 1AUKA 3NVLA 3NKPA 5DLTA 5LRMA 1EI6A 3IGZB 4MIVA 3WAXA 4ZG9A 4LRAA 1K7HA 3LXQA 1B8JA 4UPIA 4TN0A 1ALJA 5TJ3A 5K4PA 3BDGA 1P49A 4KM4A 2W5SA 1ELZA 4N7TA 4LR7A 2W8SA 3DPCA 3T00A 3M8WA 5EGEA 2XR9A 3TG0A
chains in the Genus database with same CATH superfamily
5L0EA 4LR8A 5DLWA 3MK0A 5KXAA 1ANIA 1AJBA 3NKOA 5INHA 3M8ZA 2D1GA 2W8DA 3UO0A 1AJCA 1FSUA 1O99A 1AJDA 4GTXA 4NWJA 4UOOA 4LRBA 1ZEDA 2ANHA 1N2LA 2G9YA 4KJDA 5EGHA 4QAXA 5IJSA 1URBA 2RH6A 4UOPA 4CXUA 4CYRA 4GTWA 2W5RA 5C66A 4GTYA 1EW2A 1ED9A 3DYCA 1KHNA 3MK2A 5GOVA 1KHLA 2GSNA 5HRTA 3B5QA 4UPHA 3Q3QA 4FDIA 5DLVA 1O98A 1E1ZP 2XRGA 5LRNA 3CMRA 4LREA 1EJJA 4NWXA 1KH9A 3WAVA 1ELYA 3M7VA 1HJKA 3UN5A 1SHNA 5GRRA 1AJAA 2QZUA 1EQJA 3OT9A 3A52A 4UPKA 3WBHA 3T02A 2GSUA 4ZGAA 1E33P 1HQAA 1ZEBA 2IUCB 5AJ9A 2IFYA 4UPLA 2W5QA 2GA3A 2W5VA 3T01A 2W5WA 4LQYA 4FDJA 3TWZA 4LR2A 2W5XA 2GSOA 3ED4A 4CXSA 1ALHA 1SHQA 4CYSA 3UN3A 4KJGA 1KHJA 4LR9A 4MHXA 4B56A 2ZKTA 1E3CP 1E2SP 2W5TA 3IDDA 2IUCA 3KD8A 3MK1A 4LRCA 1Y6VA 3E2DA 1ED8A 1N2KA 3IGYB 1ZEFA 4LRDA 1ANJA 3BDFA 4UORA 3M8YA 4KAVA 5IJQA 1URAA 1Y7AA 3SZYA 1ALKA 3WAWA 3BDHA 4ZG7A 1KH7A 5L0BA 1KH4A 3SZZA 3WAYA 3NKMA 1ALIA 2VQRA 2X98A 5L0KA 4GTZA 1EW8A 3NKRA 3NKQA 3UN2A 5LIAA 3BDGB 4ZG6A 4YR1A 1ELXA 1KHKA 1KH5A 4MY4A 1HDHA 4KAYA 1EW9A 3UNYA 4CXKA 2GLQA 3NKNA 4LRFA 3TX0A 5LQQA 1AUKA 3NVLA 3NKPA 5DLTA 5LRMA 1EI6A 3IGZB 4MIVA 3WAXA 4ZG9A 4LRAA 1K7HA 3LXQA 1B8JA 4UPIA 4TN0A 1ALJA 5TJ3A 5K4PA 3BDGA 1P49A 4KM4A 2W5SA 1ELZA 4N7TA 4LR7A 2W8SA 3DPCA 3T00A 3M8WA 5EGEA 2XR9A 3TG0A
chains in the Genus database with same CATH topology
5L0EA 4LR8A 5DLWA 3MK0A 5KXAA 1ANIA 1AJBA 3NKOA 5INHA 3M8ZA 2D1GA 2W8DA 3UO0A 1AJCA 1FSUA 1O99A 1AJDA 4GTXA 4NWJA 4UOOA 4LRBA 1ZEDA 2ANHA 1N2LA 2G9YA 4KJDA 5EGHA 4QAXA 5IJSA 1URBA 2RH6A 4UOPA 4CXUA 4CYRA 4GTWA 2W5RA 5C66A 4GTYA 1EW2A 1ED9A 3DYCA 1KHNA 3MK2A 5GOVA 1KHLA 2GSNA 5HRTA 3B5QA 4UPHA 3Q3QA 4FDIA 5DLVA 1O98A 1E1ZP 2XRGA 5LRNA 3CMRA 4LREA 1EJJA 4NWXA 1KH9A 3WAVA 1ELYA 3M7VA 1HJKA 3UN5A 1SHNA 5GRRA 1AJAA 2QZUA 1EQJA 3OT9A 3A52A 4UPKA 3WBHA 3T02A 2GSUA 4ZGAA 1E33P 1HQAA 1ZEBA 2IUCB 5AJ9A 2IFYA 4UPLA 2W5QA 2GA3A 2W5VA 3T01A 2W5WA 4LQYA 4FDJA 3TWZA 4LR2A 2W5XA 2GSOA 3ED4A 4CXSA 1ALHA 1SHQA 4CYSA 3UN3A 4KJGA 1KHJA 4LR9A 4MHXA 4B56A 2ZKTA 1E3CP 1E2SP 2W5TA 3IDDA 2IUCA 3KD8A 3MK1A 4LRCA 1Y6VA 3E2DA 1ED8A 1N2KA 3IGYB 1ZEFA 4LRDA 1ANJA 3BDFA 4UORA 3M8YA 4KAVA 5IJQA 1URAA 1Y7AA 3SZYA 1ALKA 3WAWA 3BDHA 4ZG7A 1KH7A 5L0BA 1KH4A 3SZZA 3WAYA 3NKMA 1ALIA 2VQRA 2X98A 5L0KA 4GTZA 1EW8A 3NKRA 3NKQA 3UN2A 5LIAA 3BDGB 4ZG6A 4YR1A 1ELXA 1KHKA 1KH5A 4MY4A 1HDHA 4KAYA 1EW9A 3UNYA 4CXKA 2GLQA 3NKNA 4LRFA 3TX0A 5LQQA 1AUKA 3NVLA 3NKPA 5DLTA 5LRMA 1EI6A 3IGZB 4MIVA 3WAXA 4ZG9A 4LRAA 1K7HA 3LXQA 1B8JA 4UPIA 4TN0A 1ALJA 5TJ3A 5K4PA 3BDGA 1P49A 4KM4A 2W5SA 1ELZA 4N7TA 4LR7A 2W8SA 3DPCA 3T00A 3M8WA 5EGEA 2XR9A 3TG0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0E A;  4LR8 A;  5DLW A;  3MK0 A;  5KXA A;  1ANI A;  1AJB A;  3NKO A;  5INH A;  3M8Z A;  2D1G A;  2W8D A;  3UO0 A;  1AJC A;  1FSU A;  1O99 A;  1AJD A;  4GTX A;  4NWJ A;  4UOO A;  4LRB A;  1ZED A;  2ANH A;  1N2L A;  2G9Y A;  4KJD A;  5EGH A;  4QAX A;  5IJS A;  1URB A;  2RH6 A;  4UOP A;  4CXU A;  4CYR A;  4GTW A;  2W5R A;  5C66 A;  4GTY A;  1EW2 A;  1ED9 A;  3DYC A;  1KHN A;  3MK2 A;  5GOV A;  1KHL A;  2GSN A;  5HRT A;  3B5Q A;  4UPH A;  3Q3Q A;  4FDI A;  5DLV A;  1O98 A;  1E1Z P;  2XRG A;  5LRN A;  3CMR A;  4LRE A;  1EJJ A;  4NWX A;  1KH9 A;  3WAV A;  1ELY A;  3M7V A;  1HJK A;  3UN5 A;  1SHN A;  5GRR A;  1AJA A;  2QZU A;  1EQJ A;  3OT9 A;  3A52 A;  4UPK A;  3WBH A;  3T02 A;  2GSU A;  4ZGA A;  1E33 P;  1HQA A;  1ZEB A;  2IUC B;  5AJ9 A;  2IFY A;  4UPL A;  2W5Q A;  2GA3 A;  2W5V A;  3T01 A;  2W5W A;  4LQY A;  4FDJ A;  3TWZ A;  4LR2 A;  2W5X A;  2GSO A;  3ED4 A;  4CXS A;  1ALH A;  1SHQ A;  4CYS A;  3UN3 A;  4KJG A;  1KHJ A;  4LR9 A;  4MHX A;  4B56 A;  2ZKT A;  1E3C P;  1E2S P;  2W5T A;  3IDD A;  2IUC A;  3KD8 A;  3MK1 A;  4LRC A;  1Y6V A;  3E2D A;  1ED8 A;  1N2K A;  3IGY B;  1ZEF A;  4LRD A;  1ANJ A;  3BDF A;  4UOR A;  3M8Y A;  4KAV A;  5IJQ A;  1URA A;  1Y7A A;  3SZY A;  1ALK A;  3WAW A;  3BDH A;  4ZG7 A;  1KH7 A;  5L0B A;  1KH4 A;  3SZZ A;  3WAY A;  3NKM A;  1ALI A;  2VQR A;  2X98 A;  5L0K A;  4GTZ A;  1EW8 A;  3NKR A;  3NKQ A;  3UN2 A;  5LIA A;  3BDG B;  4ZG6 A;  4YR1 A;  1ELX A;  1KHK A;  1KH5 A;  4MY4 A;  1HDH A;  4KAY A;  1EW9 A;  3UNY A;  4CXK A;  2GLQ A;  3NKN A;  4LRF A;  3TX0 A;  5LQQ A;  1AUK A;  3NVL A;  3NKP A;  5DLT A;  5LRM A;  1EI6 A;  3IGZ B;  4MIV A;  3WAX A;  4ZG9 A;  4LRA A;  1K7H A;  3LXQ A;  1B8J A;  4UPI A;  4TN0 A;  1ALJ A;  5TJ3 A;  5K4P A;  3BDG A;  1P49 A;  4KM4 A;  2W5S A;  1ELZ A;  4N7T A;  4LR7 A;  2W8S A;  3DPC A;  3T00 A;  3M8W A;  5EGE A;  2XR9 A;  3TG0 A; 
#chains in the Genus database with same CATH topology
 5L0E A;  4LR8 A;  5DLW A;  3MK0 A;  5KXA A;  1ANI A;  1AJB A;  3NKO A;  5INH A;  3M8Z A;  2D1G A;  2W8D A;  3UO0 A;  1AJC A;  1FSU A;  1O99 A;  1AJD A;  4GTX A;  4NWJ A;  4UOO A;  4LRB A;  1ZED A;  2ANH A;  1N2L A;  2G9Y A;  4KJD A;  5EGH A;  4QAX A;  5IJS A;  1URB A;  2RH6 A;  4UOP A;  4CXU A;  4CYR A;  4GTW A;  2W5R A;  5C66 A;  4GTY A;  1EW2 A;  1ED9 A;  3DYC A;  1KHN A;  3MK2 A;  5GOV A;  1KHL A;  2GSN A;  5HRT A;  3B5Q A;  4UPH A;  3Q3Q A;  4FDI A;  5DLV A;  1O98 A;  1E1Z P;  2XRG A;  5LRN A;  3CMR A;  4LRE A;  1EJJ A;  4NWX A;  1KH9 A;  3WAV A;  1ELY A;  3M7V A;  1HJK A;  3UN5 A;  1SHN A;  5GRR A;  1AJA A;  2QZU A;  1EQJ A;  3OT9 A;  3A52 A;  4UPK A;  3WBH A;  3T02 A;  2GSU A;  4ZGA A;  1E33 P;  1HQA A;  1ZEB A;  2IUC B;  5AJ9 A;  2IFY A;  4UPL A;  2W5Q A;  2GA3 A;  2W5V A;  3T01 A;  2W5W A;  4LQY A;  4FDJ A;  3TWZ A;  4LR2 A;  2W5X A;  2GSO A;  3ED4 A;  4CXS A;  1ALH A;  1SHQ A;  4CYS A;  3UN3 A;  4KJG A;  1KHJ A;  4LR9 A;  4MHX A;  4B56 A;  2ZKT A;  1E3C P;  1E2S P;  2W5T A;  3IDD A;  2IUC A;  3KD8 A;  3MK1 A;  4LRC A;  1Y6V A;  3E2D A;  1ED8 A;  1N2K A;  3IGY B;  1ZEF A;  4LRD A;  1ANJ A;  3BDF A;  4UOR A;  3M8Y A;  4KAV A;  5IJQ A;  1URA A;  1Y7A A;  3SZY A;  1ALK A;  3WAW A;  3BDH A;  4ZG7 A;  1KH7 A;  5L0B A;  1KH4 A;  3SZZ A;  3WAY A;  3NKM A;  1ALI A;  2VQR A;  2X98 A;  5L0K A;  4GTZ A;  1EW8 A;  3NKR A;  3NKQ A;  3UN2 A;  5LIA A;  3BDG B;  4ZG6 A;  4YR1 A;  1ELX A;  1KHK A;  1KH5 A;  4MY4 A;  1HDH A;  4KAY A;  1EW9 A;  3UNY A;  4CXK A;  2GLQ A;  3NKN A;  4LRF A;  3TX0 A;  5LQQ A;  1AUK A;  3NVL A;  3NKP A;  5DLT A;  5LRM A;  1EI6 A;  3IGZ B;  4MIV A;  3WAX A;  4ZG9 A;  4LRA A;  1K7H A;  3LXQ A;  1B8J A;  4UPI A;  4TN0 A;  1ALJ A;  5TJ3 A;  5K4P A;  3BDG A;  1P49 A;  4KM4 A;  2W5S A;  1ELZ A;  4N7T A;  4LR7 A;  2W8S A;  3DPC A;  3T00 A;  3M8W A;  5EGE A;  2XR9 A;  3TG0 A; 
#chains in the Genus database with same CATH homology
 5L0E A;  4LR8 A;  5DLW A;  3MK0 A;  5KXA A;  1ANI A;  1AJB A;  3NKO A;  5INH A;  3M8Z A;  2D1G A;  2W8D A;  3UO0 A;  1AJC A;  1FSU A;  1O99 A;  1AJD A;  4GTX A;  4NWJ A;  4UOO A;  4LRB A;  1ZED A;  2ANH A;  1N2L A;  2G9Y A;  4KJD A;  5EGH A;  4QAX A;  5IJS A;  1URB A;  2RH6 A;  4UOP A;  4CXU A;  4CYR A;  4GTW A;  2W5R A;  5C66 A;  4GTY A;  1EW2 A;  1ED9 A;  3DYC A;  1KHN A;  3MK2 A;  5GOV A;  1KHL A;  2GSN A;  5HRT A;  3B5Q A;  4UPH A;  3Q3Q A;  4FDI A;  5DLV A;  1O98 A;  1E1Z P;  2XRG A;  5LRN A;  3CMR A;  4LRE A;  1EJJ A;  4NWX A;  1KH9 A;  3WAV A;  1ELY A;  3M7V A;  1HJK A;  3UN5 A;  1SHN A;  5GRR A;  1AJA A;  2QZU A;  1EQJ A;  3OT9 A;  3A52 A;  4UPK A;  3WBH A;  3T02 A;  2GSU A;  4ZGA A;  1E33 P;  1HQA A;  1ZEB A;  2IUC B;  5AJ9 A;  2IFY A;  4UPL A;  2W5Q A;  2GA3 A;  2W5V A;  3T01 A;  2W5W A;  4LQY A;  4FDJ A;  3TWZ A;  4LR2 A;  2W5X A;  2GSO A;  3ED4 A;  4CXS A;  1ALH A;  1SHQ A;  4CYS A;  3UN3 A;  4KJG A;  1KHJ A;  4LR9 A;  4MHX A;  4B56 A;  2ZKT A;  1E3C P;  1E2S P;  2W5T A;  3IDD A;  2IUC A;  3KD8 A;  3MK1 A;  4LRC A;  1Y6V A;  3E2D A;  1ED8 A;  1N2K A;  3IGY B;  1ZEF A;  4LRD A;  1ANJ A;  3BDF A;  4UOR A;  3M8Y A;  4KAV A;  5IJQ A;  1URA A;  1Y7A A;  3SZY A;  1ALK A;  3WAW A;  3BDH A;  4ZG7 A;  1KH7 A;  5L0B A;  1KH4 A;  3SZZ A;  3WAY A;  3NKM A;  1ALI A;  2VQR A;  2X98 A;  5L0K A;  4GTZ A;  1EW8 A;  3NKR A;  3NKQ A;  3UN2 A;  5LIA A;  3BDG B;  4ZG6 A;  4YR1 A;  1ELX A;  1KHK A;  1KH5 A;  4MY4 A;  1HDH A;  4KAY A;  1EW9 A;  3UNY A;  4CXK A;  2GLQ A;  3NKN A;  4LRF A;  3TX0 A;  5LQQ A;  1AUK A;  3NVL A;  3NKP A;  5DLT A;  5LRM A;  1EI6 A;  3IGZ B;  4MIV A;  3WAX A;  4ZG9 A;  4LRA A;  1K7H A;  3LXQ A;  1B8J A;  4UPI A;  4TN0 A;  1ALJ A;  5TJ3 A;  5K4P A;  3BDG A;  1P49 A;  4KM4 A;  2W5S A;  1ELZ A;  4N7T A;  4LR7 A;  2W8S A;  3DPC A;  3T00 A;  3M8W A;  5EGE A;  2XR9 A;  3TG0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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