5EPPA

Structural insights into the interaction of p97 n-terminus domain and vbm motif in rhomboid protease, rhbdl4
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
170
structure length
170
Chain Sequence
NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Transitional endoplasmic reticulum ATPase
total genus 46
structure length 170
sequence length 170
ec nomenclature ec 3.6.4.6: Vesicle-fusing ATPase.
pdb deposition date 2015-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02359 CDC48_N Cell division protein 48 (CDC48), N-terminal domain
A PF02933 CDC48_2 Cell division protein 48 (CDC48), domain 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases Barwin-like endoglucanases 5eppA01
3.10.330.10 Alpha Beta Roll Vcp-like ATPase; Chain A, domain 2 Vcp-like ATPase; Chain A, domain 2 5eppA02
2VPWA 2NVYA 1QDNA 2R92A 1H0HA 1Y1VA 1E32A 1Y5IA 2JIOA 5FTKA 5GLFA 2Y0SA 4CS0A 2VPXA 2JIQA 3IR5A 1DMSA 2E2IA 4CRYG 2YU9A 2E2HA 3ML1A 2PJHB 4KODA 1CZ5A 1PQHA 1WLFA 1Y4ZA 3QWZA 1PYQA 5EPPA 1QCSA 1PQEA 4KLNA 2JA5A 1YLEA 1Q16A 1TMOA 3IR6A 3IR7A 4QIWA 1E61A 1SFOA 1UHEA 2YUJA 1WCMA 1G8JA 1G8KA 1E60A 4GA5A 1ZC1A 3H0GA 1PPYA 1R7RA 1S3SA 2PMZA 5FTJA 3GTLA 1AW8B 2V3VA 5B6CA 2NVXA 1FDIA 4AONB 4KDLA 5FTLA 1I50A 5C1BA 3GTOA 1Y1WA 2WAQA 1VC3B 2JIRA 1TWGA 4AZDA 4AYBA 2JIMA 2NAPA 3PLXB 2B63A 4KO8A 2VPYA 4RV0A 1KQFA 1E18A 3GTJA 1CZ4A 5T5MD 3GTMA 2C45A 1AA6A 1SIWA 5T5ID 3HU2A 4GA6A 1H5NA 3QC8A 1TWAA 2DMRA 2VPZA 4CRZA 1KQGA 3GTKA 3FKIA 1PT0A 1I3QA 1OGYA 5FTMA 3TM7B 2JIPA 1R27A 3HU3A 4KDIA 3QQ8A 2E7ZA 2V45A 2EEOB 1E5VA 1EU1A 2R7ZA 3HKZA 1IW7D 3GTQA 1TWCA 3CF2A 3DMRA 2R93A 4AAYA 3TIWA 2KI8A 2IV2X 1DMRA 2VUMA 4AOKB 5DYIA 4C2MA 2NYAA 1TWHA 1UHDA 3OUGA 5DYGA 2JV2A 5FTNA 1FDOA 2WB1A 3GTPA 2JA7A 1R9TA 3HU1A 1PYUB 1K83A 3CQZA 3QQ7A 5C18A 3O5AA 2JA6A 3GTGA 1TWFA 1PT1A 4D7ZB 4DMRA 1PQFA 1CR5A
chains in the Genus database with same CATH superfamily
2VPWA 2NVYA 2ENGA 1QDNA 4JP7A 3X2JA 2R92A 1H0HA 1Y1VA 3ZJVA 1E32A 2AE0X 1Y5IA 2JIOA 5EQJB 3ZJTA 2BE5D 2PICA 5FTKA 5GLFA 2MM0A 2Y0SA 1HD5A 4CS0A 2VPXA 2JIQA 1BW3A 2G5DA 5ERGB 3IR5A 1DMSA 2E2IA 3FPUA 5D6WA 4CRYG 2YU9A 4JP6A 2E2HA 3ML1A 2PJHB 4KODA 3X2MA 2QQSA 1CZ5A 1L8FA 1PQHA 1WLFA 1Y4ZA 4L48A 3QWZA 1PYQA 2B25A 5EPPA 1QCSA 4FIBA 3ZGZA 1PQEA 2PJJA 4KLNA 2GF7A 2HCZX 2Q1AX 5CCXA 3MB5A 2JA5A 1YLEA 5CCBA 1Q16A 1TMOA 3IR6A 3IR7A 1WC2A 1E61A 4QIWA 1UHEA 2YUJA 1SFOA 1WCMA 1G8JA 1G8KA 1E60A 2A6HD 3X2IA 4GA5A 2Q1CX 1OA7A 1ZC1A 3H0GA 1PPYA 1R7RA 3LHDA 1S3SA 3X2KA 2PMZA 4FERA 5FTJA 3GTLA 2GFAA 3LGAA 2Q1DX 1AW8B 2V3VA 5B6CA 1YNND 2BH0A 1FDIA 3X2OA 4KDLA 4JS7A 4AONB 3SULA 5C1BA 2KQAA 5FTLA 1I50A 5GM9A 2WAQA 3GTOA 1VC3B 1Y1WA 2MM2A 1OA9A 2JIRA 3M3GA 5H4UA 2PNWA 1TWGA 2Q19X 4AZDA 4AYBA 5CD1A 2JIMA 3ENGA 5GLXA 2NAPA 3PLXB 2B63A 3BQBA 5D6YA 4KO8A 2VPYA 4RV0A 1KQFA 1E18A 3GTJA 1CZ4A 3FPRA 4UC4A 5T5MD 3GTMA 3D30A 4ENGA 2C45A 1AA6A 1N10A 4ARIA 2QQRA 1SIWA 4AQ7A 4ZM7A 2PI8A 5T5ID 3HU2A 2O5JD 4GA6A 1H5NA 3QC8A 1SMYD 1TWAA 2DMRA 1YNJD 2VPZA 5GLYA 4CRZA 1KQGA 3SUJA 3CZBA 3GTKA 3FKIA 4JCWA 2Q18X 3X2HA 1PT0A 5D6XA 1I3QA 3FPTA 1OGYA 2A69D 5FTMA 3TM7B 2JIPA 1BW4A 4CQNA 1R27A 3HU3A 4KDIA 3SUMA 3QQ8A 2NVXA 2E7ZA 2V45A 2EEOB 1E5VA 1EU1A 2GAEA 4NOHA 2R7ZA 2CW0D 3HKZA 1IW7D 3GTQA 1TWCA 3CF2A 3DMRA 3X2NA 2R93A 4AAYA 3TIWA 1O54A 2LW6A 2KI8A 1I9GA 2A6ED 2IV2X 1DMRA 2VUMA 4AOKB 5DYIA 4C2MA 2NYAA 1TWHA 4AVRA 1UHDA 3OUGA 5DYGA 3X2PA 2YVLA 2JV2A 5FTNA 2KY9A 1FDOA 2A68D 4FFTA 3X2GA 1ZYRD 2WB1A 3GTPA 3SUKA 2PWYA 4FG4A 2JA7A 3ZJUA 1R9TA 4AS1A 3HU1A 1PYUB 4JJOA 2G6GA 1K83A 3CQZA 3QQ7A 3X2LA 4ARCA 5C18A 3O5AA 2JA6A 3GTGA 1TWFA 2XDPA 1PT1A 4D7ZB 4DMRA 4FG2A 1PQFA 1CR5A
chains in the Genus database with same CATH topology
2VPWA 2NVYA 1QDNA 2R92A 1H0HA 1Y1VA 3ZJVA 1E32A 2AE0X 1Y5IA 2JIOA 5EQJB 3ZJTA 2BE5D 2PICA 5FTKA 5GLFA 2MM0A 2Y0SA 4CS0A 2VPXA 2JIQA 2G5DA 5ERGB 3IR5A 1DMSA 2E2IA 3FPUA 5D6WA 4CRYG 2YU9A 2E2HA 3ML1A 2PJHB 4KODA 2QQSA 1CZ5A 1PQHA 1WLFA 1Y4ZA 2B25A 3QWZA 1PYQA 4FIBA 5EPPA 1QCSA 3ZGZA 1PQEA 2PJJA 4KLNA 2GF7A 2Q1AX 5CCXA 3MB5A 2JA5A 1YLEA 5CCBA 1Q16A 1TMOA 3IR6A 3IR7A 4QIWA 1E61A 1SFOA 1UHEA 2YUJA 1WCMA 1G8JA 1G8KA 1E60A 2A6HD 4GA5A 2Q1CX 1ZC1A 3LHDA 3H0GA 1PPYA 1R7RA 1S3SA 2PMZA 5FTJA 3GTLA 2GFAA 3LGAA 2Q1DX 1AW8B 2V3VA 5B6CA 1YNND 2NVXA 1FDIA 4AONB 4KDLA 5FTLA 1I50A 5C1BA 3GTOA 1Y1WA 2MM2A 2WAQA 1VC3B 2JIRA 2PNWA 1TWGA 2Q19X 4AZDA 4AYBA 5CD1A 2JIMA 2NAPA 3PLXB 2B63A 3BQBA 5D6YA 4KO8A 2VPYA 4RV0A 1KQFA 1E18A 3GTJA 1CZ4A 3FPRA 4UC4A 5T5MD 3GTMA 2C45A 1AA6A 4ARIA 2QQRA 1SIWA 4AQ7A 2PI8A 5T5ID 3HU2A 2O5JD 4GA6A 1H5NA 3QC8A 1SMYD 1TWAA 2DMRA 1YNJD 2VPZA 4CRZA 1KQGA 3GTKA 3CZBA 3FKIA 2Q18X 1PT0A 5D6XA 1I3QA 3FPTA 1OGYA 2A69D 5FTMA 3TM7B 2JIPA 4CQNA 1R27A 3HU3A 4KDIA 3QQ8A 2E7ZA 2V45A 2EEOB 1E5VA 1EU1A 2GAEA 4NOHA 2R7ZA 2CW0D 3HKZA 1IW7D 3GTQA 1TWCA 3CF2A 3DMRA 2R93A 1O54A 4AAYA 3TIWA 2LW6A 2KI8A 1I9GA 2A6ED 2IV2X 1DMRA 2VUMA 4AOKB 5DYIA 4C2MA 2NYAA 1TWHA 1UHDA 3OUGA 5DYGA 2YVLA 2JV2A 5FTNA 2KY9A 1FDOA 2A68D 1ZYRD 2WB1A 3GTPA 2PWYA 2JA7A 3ZJUA 1R9TA 4AS1A 3HU1A 1PYUB 2G6GA 1K83A 3CQZA 3QQ7A 4ARCA 5C18A 3O5AA 2JA6A 3GTGA 1TWFA 2XDPA 1PT1A 4D7ZB 4DMRA 1PQFA 1CR5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VPW A;  2NVY A;  1QDN A;  2R92 A;  1H0H A;  1Y1V A;  1E32 A;  1Y5I A;  2JIO A;  5FTK A;  5GLF A;  2Y0S A;  4CS0 A;  2VPX A;  2JIQ A;  3IR5 A;  1DMS A;  2E2I A;  4CRY G;  2YU9 A;  2E2H A;  3ML1 A;  2PJH B;  4KOD A;  1CZ5 A;  1PQH A;  1WLF A;  1Y4Z A;  3QWZ A;  1PYQ A;  5EPP A;  1QCS A;  1PQE A;  4KLN A;  2JA5 A;  1YLE A;  1Q16 A;  1TMO A;  3IR6 A;  3IR7 A;  4QIW A;  1E61 A;  1SFO A;  1UHE A;  2YUJ A;  1WCM A;  1G8J A;  1G8K A;  1E60 A;  4GA5 A;  1ZC1 A;  3H0G A;  1PPY A;  1R7R A;  1S3S A;  2PMZ A;  5FTJ A;  3GTL A;  1AW8 B;  2V3V A;  5B6C A;  2NVX A;  1FDI A;  4AON B;  4KDL A;  5FTL A;  1I50 A;  5C1B A;  3GTO A;  1Y1W A;  2WAQ A;  1VC3 B;  2JIR A;  1TWG A;  4AZD A;  4AYB A;  2JIM A;  2NAP A;  3PLX B;  2B63 A;  4KO8 A;  2VPY A;  4RV0 A;  1KQF A;  1E18 A;  3GTJ A;  1CZ4 A;  5T5M D;  3GTM A;  2C45 A;  1AA6 A;  1SIW A;  5T5I D;  3HU2 A;  4GA6 A;  1H5N A;  3QC8 A;  1TWA A;  2DMR A;  2VPZ A;  4CRZ A;  1KQG A;  3GTK A;  3FKI A;  1PT0 A;  1I3Q A;  1OGY A;  5FTM A;  3TM7 B;  2JIP A;  1R27 A;  3HU3 A;  4KDI A;  3QQ8 A;  2E7Z A;  2V45 A;  2EEO B;  1E5V A;  1EU1 A;  2R7Z A;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  3CF2 A;  3DMR A;  2R93 A;  4AAY A;  3TIW A;  2KI8 A;  2IV2 X;  1DMR A;  2VUM A;  4AOK B;  5DYI A;  4C2M A;  2NYA A;  1TWH A;  1UHD A;  3OUG A;  5DYG A;  2JV2 A;  5FTN A;  1FDO A;  2WB1 A;  3GTP A;  2JA7 A;  1R9T A;  3HU1 A;  1PYU B;  1K83 A;  3CQZ A;  3QQ7 A;  5C18 A;  3O5A A;  2JA6 A;  3GTG A;  1TWF A;  1PT1 A;  4D7Z B;  4DMR A;  1PQF A;  1CR5 A; 
#chains in the Genus database with same CATH topology
 2VPW A;  2NVY A;  2ENG A;  1QDN A;  4JP7 A;  3X2J A;  2R92 A;  1H0H A;  1Y1V A;  3ZJV A;  1E32 A;  2AE0 X;  1Y5I A;  2JIO A;  5EQJ B;  3ZJT A;  2BE5 D;  2PIC A;  5FTK A;  5GLF A;  2MM0 A;  2Y0S A;  1HD5 A;  4CS0 A;  2VPX A;  2JIQ A;  1BW3 A;  2G5D A;  5ERG B;  3IR5 A;  1DMS A;  2E2I A;  3FPU A;  5D6W A;  4CRY G;  2YU9 A;  4JP6 A;  2E2H A;  3ML1 A;  2PJH B;  4KOD A;  3X2M A;  2QQS A;  1CZ5 A;  1L8F A;  1PQH A;  1WLF A;  1Y4Z A;  4L48 A;  3QWZ A;  1PYQ A;  2B25 A;  5EPP A;  1QCS A;  4FIB A;  3ZGZ A;  1PQE A;  2PJJ A;  4KLN A;  2GF7 A;  2HCZ X;  2Q1A X;  5CCX A;  3MB5 A;  2JA5 A;  1YLE A;  5CCB A;  1Q16 A;  1TMO A;  3IR6 A;  3IR7 A;  1WC2 A;  1E61 A;  4QIW A;  1UHE A;  2YUJ A;  1SFO A;  1WCM A;  1G8J A;  1G8K A;  1E60 A;  2A6H D;  3X2I A;  4GA5 A;  2Q1C X;  1OA7 A;  1ZC1 A;  3H0G A;  1PPY A;  1R7R A;  3LHD A;  1S3S A;  3X2K A;  2PMZ A;  4FER A;  5FTJ A;  3GTL A;  2GFA A;  3LGA A;  2Q1D X;  1AW8 B;  2V3V A;  5B6C A;  1YNN D;  2BH0 A;  1FDI A;  3X2O A;  4KDL A;  4JS7 A;  4AON B;  3SUL A;  5C1B A;  2KQA A;  5FTL A;  1I50 A;  5GM9 A;  2WAQ A;  3GTO A;  1VC3 B;  1Y1W A;  2MM2 A;  1OA9 A;  2JIR A;  3M3G A;  5H4U A;  2PNW A;  1TWG A;  2Q19 X;  4AZD A;  4AYB A;  5CD1 A;  2JIM A;  3ENG A;  5GLX A;  2NAP A;  3PLX B;  2B63 A;  3BQB A;  5D6Y A;  4KO8 A;  2VPY A;  4RV0 A;  1KQF A;  1E18 A;  3GTJ A;  1CZ4 A;  3FPR A;  4UC4 A;  5T5M D;  3GTM A;  3D30 A;  4ENG A;  2C45 A;  1AA6 A;  1N10 A;  4ARI A;  2QQR A;  1SIW A;  4AQ7 A;  4ZM7 A;  2PI8 A;  5T5I D;  3HU2 A;  2O5J D;  4GA6 A;  1H5N A;  3QC8 A;  1SMY D;  1TWA A;  2DMR A;  1YNJ D;  2VPZ A;  5GLY A;  4CRZ A;  1KQG A;  3SUJ A;  3CZB A;  3GTK A;  3FKI A;  4JCW A;  2Q18 X;  3X2H A;  1PT0 A;  5D6X A;  1I3Q A;  3FPT A;  1OGY A;  2A69 D;  5FTM A;  3TM7 B;  2JIP A;  1BW4 A;  4CQN A;  1R27 A;  3HU3 A;  4KDI A;  3SUM A;  3QQ8 A;  2NVX A;  2E7Z A;  2V45 A;  2EEO B;  1E5V A;  1EU1 A;  2GAE A;  4NOH A;  2R7Z A;  2CW0 D;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  3CF2 A;  3DMR A;  3X2N A;  2R93 A;  4AAY A;  3TIW A;  1O54 A;  2LW6 A;  2KI8 A;  1I9G A;  2A6E D;  2IV2 X;  1DMR A;  2VUM A;  4AOK B;  5DYI A;  4C2M A;  2NYA A;  1TWH A;  4AVR A;  1UHD A;  3OUG A;  5DYG A;  3X2P A;  2YVL A;  2JV2 A;  5FTN A;  2KY9 A;  1FDO A;  2A68 D;  4FFT A;  3X2G A;  1ZYR D;  2WB1 A;  3GTP A;  3SUK A;  2PWY A;  4FG4 A;  2JA7 A;  3ZJU A;  1R9T A;  4AS1 A;  3HU1 A;  1PYU B;  4JJO A;  2G6G A;  1K83 A;  3CQZ A;  3QQ7 A;  3X2L A;  4ARC A;  5C18 A;  3O5A A;  2JA6 A;  3GTG A;  1TWF A;  2XDP A;  1PT1 A;  4D7Z B;  4DMR A;  4FG2 A;  1PQF A;  1CR5 A; 
#chains in the Genus database with same CATH homology
 2VPW A;  2NVY A;  1QDN A;  2R92 A;  1H0H A;  1Y1V A;  3ZJV A;  1E32 A;  2AE0 X;  1Y5I A;  2JIO A;  5EQJ B;  3ZJT A;  2BE5 D;  2PIC A;  5FTK A;  5GLF A;  2MM0 A;  2Y0S A;  4CS0 A;  2VPX A;  2JIQ A;  2G5D A;  5ERG B;  3IR5 A;  1DMS A;  2E2I A;  3FPU A;  5D6W A;  4CRY G;  2YU9 A;  2E2H A;  3ML1 A;  2PJH B;  4KOD A;  2QQS A;  1CZ5 A;  1PQH A;  1WLF A;  1Y4Z A;  2B25 A;  3QWZ A;  1PYQ A;  4FIB A;  5EPP A;  1QCS A;  3ZGZ A;  1PQE A;  2PJJ A;  4KLN A;  2GF7 A;  2Q1A X;  5CCX A;  3MB5 A;  2JA5 A;  1YLE A;  5CCB A;  1Q16 A;  1TMO A;  3IR6 A;  3IR7 A;  4QIW A;  1E61 A;  1SFO A;  1UHE A;  2YUJ A;  1WCM A;  1G8J A;  1G8K A;  1E60 A;  2A6H D;  4GA5 A;  2Q1C X;  1ZC1 A;  3LHD A;  3H0G A;  1PPY A;  1R7R A;  1S3S A;  2PMZ A;  5FTJ A;  3GTL A;  2GFA A;  3LGA A;  2Q1D X;  1AW8 B;  2V3V A;  5B6C A;  1YNN D;  2NVX A;  1FDI A;  4AON B;  4KDL A;  5FTL A;  1I50 A;  5C1B A;  3GTO A;  1Y1W A;  2MM2 A;  2WAQ A;  1VC3 B;  2JIR A;  2PNW A;  1TWG A;  2Q19 X;  4AZD A;  4AYB A;  5CD1 A;  2JIM A;  2NAP A;  3PLX B;  2B63 A;  3BQB A;  5D6Y A;  4KO8 A;  2VPY A;  4RV0 A;  1KQF A;  1E18 A;  3GTJ A;  1CZ4 A;  3FPR A;  4UC4 A;  5T5M D;  3GTM A;  2C45 A;  1AA6 A;  4ARI A;  2QQR A;  1SIW A;  4AQ7 A;  2PI8 A;  5T5I D;  3HU2 A;  2O5J D;  4GA6 A;  1H5N A;  3QC8 A;  1SMY D;  1TWA A;  2DMR A;  1YNJ D;  2VPZ A;  4CRZ A;  1KQG A;  3GTK A;  3CZB A;  3FKI A;  2Q18 X;  1PT0 A;  5D6X A;  1I3Q A;  3FPT A;  1OGY A;  2A69 D;  5FTM A;  3TM7 B;  2JIP A;  4CQN A;  1R27 A;  3HU3 A;  4KDI A;  3QQ8 A;  2E7Z A;  2V45 A;  2EEO B;  1E5V A;  1EU1 A;  2GAE A;  4NOH A;  2R7Z A;  2CW0 D;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  3CF2 A;  3DMR A;  2R93 A;  1O54 A;  4AAY A;  3TIW A;  2LW6 A;  2KI8 A;  1I9G A;  2A6E D;  2IV2 X;  1DMR A;  2VUM A;  4AOK B;  5DYI A;  4C2M A;  2NYA A;  1TWH A;  1UHD A;  3OUG A;  5DYG A;  2YVL A;  2JV2 A;  5FTN A;  2KY9 A;  1FDO A;  2A68 D;  1ZYR D;  2WB1 A;  3GTP A;  2PWY A;  2JA7 A;  3ZJU A;  1R9T A;  4AS1 A;  3HU1 A;  1PYU B;  2G6G A;  1K83 A;  3CQZ A;  3QQ7 A;  4ARC A;  5C18 A;  3O5A A;  2JA6 A;  3GTG A;  1TWF A;  2XDP A;  1PT1 A;  4D7Z B;  4DMR A;  1PQF A;  1CR5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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