5GLFA

Structural insights into the interaction of p97 n-terminal domain and shp motif in derlin-1 rhomboid pseudoprotease
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
170
structure length
170
Chain Sequence
PNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
pubmed doi rcsb
molecule tags Hydrolase/transport protein
source organism Homo sapiens
molecule keywords Transitional endoplasmic reticulum ATPase
total genus 48
structure length 170
sequence length 170
chains with identical sequence C, E, G
ec nomenclature ec 3.6.4.6: Vesicle-fusing ATPase.
pdb deposition date 2016-07-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02359 CDC48_N Cell division protein 48 (CDC48), N-terminal domain
A PF02933 CDC48_2 Cell division protein 48 (CDC48), domain 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases Barwin-like endoglucanases 5glfA01
3.10.330.10 Alpha Beta Roll Vcp-like ATPase; Chain A, domain 2 Vcp-like ATPase; Chain A, domain 2 5glfA02
3CF2A 1TWGA 4CRZA 1H5NA 1YLEA 1PT0A 3H0GA 2WB1A 3GTLA 1KQGA 4CS0A 2VPYA 1TWFA 1DMSA 5FTMA 3HU3A 1R27A 4AOKB 1Y1WA 3PLXB 2VPXA 2V45A 3CQZA 3QQ8A 5DYIA 2VUMA 3HU2A 2JV2A 1I50A 1WLFA 1Q16A 1H0HA 1S3SA 1TMOA 1UHEA 2EEOB 4AAYA 3O5AA 1CR5A 1PT1A 1SFOA 4CRYG 1TWAA 5FTJA 2NYAA 2R7ZA 3GTPA 2B63A 3GTQA 2E2HA 1G8KA 1E5VA 1DMRA 4AYBA 1TWHA 1FDIA 5FTLA 2NVYA 1I3QA 2R93A 1E61A 1OGYA 4KLNA 3TM7B 5FTKA 3GTKA 1Y5IA 3IR6A 2NVXA 5FTNA 2C45A 3IR7A 2JA5A 2YUJA 1EU1A 2Y0SA 1AA6A 1E60A 2E7ZA 2JA7A 5T5MD 1WCMA 1PPYA 3QWZA 5DYGA 4RV0A 4AZDA 3IR5A 5C18A 1VC3B 2VPWA 2DMRA 1IW7D 2KI8A 5GLFA 2R92A 1K83A 1E18A 1R9TA 2E2IA 1PYQA 1KQFA 5T5ID 3TIWA 1Y1VA 3HKZA 1QDNA 5EPPA 4D7ZB 2PMZA 2JA6A 1QCSA 3GTGA 4KO8A 1G8JA 1R7RA 1SIWA 4GA5A 3GTJA 2PJHB 4DMRA 1CZ4A 2WAQA 1ZC1A 1CZ5A 4GA6A 3HU1A 2JIRA 4KODA 2JIQA 1TWCA 2VPZA 1PQHA 4KDIA 1UHDA 2JIPA 4C2MA 2NAPA 3QQ7A 1PQEA 2IV2X 2V3VA 3QC8A 5C1BA 3OUGA 2JIOA 3DMRA 3FKIA 2JIMA 5B6CA 3GTMA 1E32A 4KDLA 3GTOA 3ML1A 1AW8B 1FDOA 2YU9A 4AONB 1PYUB 1Y4ZA 4QIWA 1PQFA
chains in the Genus database with same CATH superfamily
4UC4A 3CF2A 5GLXA 1TWGA 2Q18X 4CRZA 3SUKA 4FG2A 1H5NA 1YLEA 1PT0A 3FPUA 3H0GA 2WB1A 3GTLA 3SUJA 1KQGA 4CS0A 2Q1DX 2O5JD 2GAEA 2VPYA 1TWFA 2PNWA 1DMSA 3X2KA 2G5DA 2ENGA 2MM0A 3FPTA 5FTMA 3HU3A 1BW4A 1R27A 4AOKB 1Y1WA 2Q1AX 3CZBA 3PLXB 2VPXA 2V45A 3ENGA 4JS7A 3CQZA 3QQ8A 5DYIA 5CCXA 4JJOA 2PJJA 2VUMA 3HU2A 2JV2A 2KQAA 1I50A 1WLFA 1Q16A 4ENGA 2Q19X 1H0HA 1S3SA 1TMOA 1UHEA 2EEOB 4AAYA 3O5AA 4ZM7A 4AQ7A 3X2GA 2QQRA 1CR5A 1PT1A 1SFOA 4CRYG 5D6WA 1TWAA 3X2IA 3LHDA 5FTJA 2NYAA 2R7ZA 3X2LA 3GTPA 2B63A 3GTQA 2E2HA 3ZGZA 1G8KA 1BW3A 1OA7A 4FG4A 4CQNA 1E5VA 1DMRA 1OA9A 3SULA 1TWHA 1FDIA 4AYBA 2NVYA 5FTLA 1I3QA 2Q1CX 4AS1A 2R93A 1E61A 2A69D 2A6ED 1I9GA 3D30A 1OGYA 4L48A 4KLNA 3TM7B 1O54A 5FTKA 3GTKA 1N10A 1Y5IA 3IR6A 2NVXA 3FPRA 5FTNA 2KY9A 5EQJB 2C45A 3IR7A 2JA5A 2YUJA 1EU1A 2Y0SA 4JCWA 1AA6A 4ARCA 2MM2A 1E60A 2E7ZA 2A6HD 2JA7A 5T5MD 4FERA 3ZJUA 1YNJD 2QQSA 1WCMA 3X2JA 1PPYA 3QWZA 5DYGA 5CCBA 3X2PA 4RV0A 4AZDA 3IR5A 3X2MA 1VC3B 2VPWA 4AVRA 5C18A 2DMRA 2A68D 5GM9A 1IW7D 2XDPA 2KI8A 5GLFA 2R92A 3ZJVA 2GF7A 1K83A 1E18A 1R9TA 2G6GA 2E2IA 2AE0X 5CD1A 1L8FA 5D6YA 1PYQA 1KQFA 5T5ID 3TIWA 1Y1VA 3HKZA 1QDNA 5EPPA 4D7ZB 2PMZA 2JA6A 1QCSA 3GTGA 4FFTA 4KO8A 1G8JA 1R7RA 1SIWA 3X2NA 2BH0A 2HCZX 4GA5A 3GTJA 2PJHB 4NOHA 4DMRA 2CW0D 4FIBA 1CZ4A 1ZC1A 2WAQA 3MB5A 1CZ5A 4GA6A 3HU1A 2JIRA 4KODA 3LGAA 2JIQA 1TWCA 3X2OA 2LW6A 2YVLA 1HD5A 2VPZA 1PQHA 4KDIA 1UHDA 1ZYRD 2JIPA 5H4UA 4C2MA 3X2HA 2PWYA 2NAPA 3QQ7A 5ERGB 2B25A 1PQEA 2IV2X 2V3VA 3M3GA 4JP6A 3QC8A 5GLYA 5D6XA 5C1BA 3OUGA 2PI8A 2JIOA 1YNND 3DMRA 3FKIA 2JIMA 5B6CA 2PICA 1E32A 3GTMA 4KDLA 3GTOA 3ML1A 1AW8B 1SMYD 4JP7A 3BQBA 4ARIA 1FDOA 2YU9A 2BE5D 3SUMA 4AONB 2GFAA 1PYUB 1Y4ZA 1WC2A 4QIWA 1PQFA 3ZJTA
chains in the Genus database with same CATH topology
4UC4A 3CF2A 1TWGA 2Q18X 4CRZA 1H5NA 1YLEA 1PT0A 3FPUA 3H0GA 2WB1A 3GTLA 1KQGA 2Q1DX 4CS0A 2O5JD 2GAEA 2VPYA 1TWFA 2PNWA 1DMSA 2G5DA 2MM0A 3FPTA 5FTMA 3HU3A 1R27A 4AOKB 1Y1WA 2Q1AX 3CZBA 3PLXB 2VPXA 2V45A 3CQZA 3QQ8A 5DYIA 5CCXA 2PJJA 2VUMA 3HU2A 2JV2A 1I50A 1WLFA 1Q16A 2Q19X 1H0HA 1S3SA 1TMOA 1UHEA 2EEOB 4AAYA 3O5AA 4AQ7A 2QQRA 1CR5A 1PT1A 1SFOA 4CRYG 5D6WA 1TWAA 3LHDA 5FTJA 2NYAA 2R7ZA 3GTPA 2B63A 3GTQA 2E2HA 3ZGZA 1G8KA 4CQNA 1E5VA 1DMRA 4AYBA 1TWHA 1FDIA 5FTLA 2NVYA 1I3QA 2Q1CX 4AS1A 2R93A 1E61A 2A69D 2A6ED 1I9GA 1OGYA 4KLNA 3TM7B 1O54A 5FTKA 3GTKA 1Y5IA 3IR6A 2NVXA 3FPRA 5FTNA 2KY9A 5EQJB 2C45A 3IR7A 2JA5A 2YUJA 1EU1A 2Y0SA 1AA6A 4ARCA 2MM2A 1E60A 2E7ZA 2A6HD 2JA7A 5T5MD 3ZJUA 1YNJD 2QQSA 1WCMA 1PPYA 3QWZA 5DYGA 5CCBA 4RV0A 4AZDA 3IR5A 5C18A 1VC3B 2VPWA 2DMRA 2A68D 1IW7D 2XDPA 2KI8A 5GLFA 2R92A 3ZJVA 2GF7A 1K83A 1E18A 1R9TA 2G6GA 2E2IA 2AE0X 5CD1A 5D6YA 1PYQA 1KQFA 5T5ID 3TIWA 1Y1VA 3HKZA 1QDNA 5EPPA 4D7ZB 2PMZA 2JA6A 1QCSA 3GTGA 4KO8A 1G8JA 1R7RA 1SIWA 4GA5A 3GTJA 2PJHB 4DMRA 2CW0D 4FIBA 1CZ4A 1ZC1A 2WAQA 3MB5A 1CZ5A 4GA6A 3HU1A 2JIRA 4KODA 3LGAA 2JIQA 1TWCA 2LW6A 2YVLA 2VPZA 1PQHA 4KDIA 1UHDA 1ZYRD 2JIPA 4C2MA 2PWYA 5ERGB 2NAPA 3QQ7A 2B25A 1PQEA 2IV2X 2V3VA 3QC8A 5D6XA 5C1BA 3OUGA 2PI8A 2JIOA 1YNND 3DMRA 3FKIA 2JIMA 5B6CA 2PICA 1E32A 3GTMA 4KDLA 3GTOA 3ML1A 1AW8B 1SMYD 3BQBA 4ARIA 1FDOA 2YU9A 2BE5D 2GFAA 4AONB 1PYUB 1Y4ZA 4NOHA 4QIWA 1PQFA 3ZJTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CF2 A;  1TWG A;  4CRZ A;  1H5N A;  1YLE A;  1PT0 A;  3H0G A;  2WB1 A;  3GTL A;  1KQG A;  4CS0 A;  2VPY A;  1TWF A;  1DMS A;  5FTM A;  3HU3 A;  1R27 A;  4AOK B;  1Y1W A;  3PLX B;  2VPX A;  2V45 A;  3CQZ A;  3QQ8 A;  5DYI A;  2VUM A;  3HU2 A;  2JV2 A;  1I50 A;  1WLF A;  1Q16 A;  1H0H A;  1S3S A;  1TMO A;  1UHE A;  2EEO B;  4AAY A;  3O5A A;  1CR5 A;  1PT1 A;  1SFO A;  4CRY G;  1TWA A;  5FTJ A;  2NYA A;  2R7Z A;  3GTP A;  2B63 A;  3GTQ A;  2E2H A;  1G8K A;  1E5V A;  1DMR A;  4AYB A;  1TWH A;  1FDI A;  5FTL A;  2NVY A;  1I3Q A;  2R93 A;  1E61 A;  1OGY A;  4KLN A;  3TM7 B;  5FTK A;  3GTK A;  1Y5I A;  3IR6 A;  2NVX A;  5FTN A;  2C45 A;  3IR7 A;  2JA5 A;  2YUJ A;  1EU1 A;  2Y0S A;  1AA6 A;  1E60 A;  2E7Z A;  2JA7 A;  5T5M D;  1WCM A;  1PPY A;  3QWZ A;  5DYG A;  4RV0 A;  4AZD A;  3IR5 A;  5C18 A;  1VC3 B;  2VPW A;  2DMR A;  1IW7 D;  2KI8 A;  5GLF A;  2R92 A;  1K83 A;  1E18 A;  1R9T A;  2E2I A;  1PYQ A;  1KQF A;  5T5I D;  3TIW A;  1Y1V A;  3HKZ A;  1QDN A;  5EPP A;  4D7Z B;  2PMZ A;  2JA6 A;  1QCS A;  3GTG A;  4KO8 A;  1G8J A;  1R7R A;  1SIW A;  4GA5 A;  3GTJ A;  2PJH B;  4DMR A;  1CZ4 A;  2WAQ A;  1ZC1 A;  1CZ5 A;  4GA6 A;  3HU1 A;  2JIR A;  4KOD A;  2JIQ A;  1TWC A;  2VPZ A;  1PQH A;  4KDI A;  1UHD A;  2JIP A;  4C2M A;  2NAP A;  3QQ7 A;  1PQE A;  2IV2 X;  2V3V A;  3QC8 A;  5C1B A;  3OUG A;  2JIO A;  3DMR A;  3FKI A;  2JIM A;  5B6C A;  3GTM A;  1E32 A;  4KDL A;  3GTO A;  3ML1 A;  1AW8 B;  1FDO A;  2YU9 A;  4AON B;  1PYU B;  1Y4Z A;  4QIW A;  1PQF A; 
#chains in the Genus database with same CATH topology
 4UC4 A;  3CF2 A;  5GLX A;  1TWG A;  2Q18 X;  4CRZ A;  3SUK A;  4FG2 A;  1H5N A;  1YLE A;  1PT0 A;  3FPU A;  3H0G A;  2WB1 A;  3GTL A;  3SUJ A;  1KQG A;  4CS0 A;  2Q1D X;  2O5J D;  2GAE A;  2VPY A;  1TWF A;  2PNW A;  1DMS A;  3X2K A;  2G5D A;  2ENG A;  2MM0 A;  3FPT A;  5FTM A;  3HU3 A;  1BW4 A;  1R27 A;  4AOK B;  1Y1W A;  2Q1A X;  3CZB A;  3PLX B;  2VPX A;  2V45 A;  3ENG A;  4JS7 A;  3CQZ A;  3QQ8 A;  5DYI A;  5CCX A;  4JJO A;  2PJJ A;  2VUM A;  3HU2 A;  2JV2 A;  2KQA A;  1I50 A;  1WLF A;  1Q16 A;  4ENG A;  2Q19 X;  1H0H A;  1S3S A;  1TMO A;  1UHE A;  2EEO B;  4AAY A;  3O5A A;  4ZM7 A;  4AQ7 A;  3X2G A;  2QQR A;  1CR5 A;  1PT1 A;  1SFO A;  4CRY G;  5D6W A;  1TWA A;  3X2I A;  3LHD A;  5FTJ A;  2NYA A;  2R7Z A;  3X2L A;  3GTP A;  2B63 A;  3GTQ A;  2E2H A;  3ZGZ A;  1G8K A;  1BW3 A;  1OA7 A;  4FG4 A;  4CQN A;  1E5V A;  1DMR A;  1OA9 A;  3SUL A;  1TWH A;  1FDI A;  4AYB A;  2NVY A;  5FTL A;  1I3Q A;  2Q1C X;  4AS1 A;  2R93 A;  1E61 A;  2A69 D;  2A6E D;  1I9G A;  3D30 A;  1OGY A;  4L48 A;  4KLN A;  3TM7 B;  1O54 A;  5FTK A;  3GTK A;  1N10 A;  1Y5I A;  3IR6 A;  2NVX A;  3FPR A;  5FTN A;  2KY9 A;  5EQJ B;  2C45 A;  3IR7 A;  2JA5 A;  2YUJ A;  1EU1 A;  2Y0S A;  4JCW A;  1AA6 A;  4ARC A;  2MM2 A;  1E60 A;  2E7Z A;  2A6H D;  2JA7 A;  5T5M D;  4FER A;  3ZJU A;  1YNJ D;  2QQS A;  1WCM A;  3X2J A;  1PPY A;  3QWZ A;  5DYG A;  5CCB A;  3X2P A;  4RV0 A;  4AZD A;  3IR5 A;  3X2M A;  1VC3 B;  2VPW A;  4AVR A;  5C18 A;  2DMR A;  2A68 D;  5GM9 A;  1IW7 D;  2XDP A;  2KI8 A;  5GLF A;  2R92 A;  3ZJV A;  2GF7 A;  1K83 A;  1E18 A;  1R9T A;  2G6G A;  2E2I A;  2AE0 X;  5CD1 A;  1L8F A;  5D6Y A;  1PYQ A;  1KQF A;  5T5I D;  3TIW A;  1Y1V A;  3HKZ A;  1QDN A;  5EPP A;  4D7Z B;  2PMZ A;  2JA6 A;  1QCS A;  3GTG A;  4FFT A;  4KO8 A;  1G8J A;  1R7R A;  1SIW A;  3X2N A;  2BH0 A;  2HCZ X;  4GA5 A;  3GTJ A;  2PJH B;  4NOH A;  4DMR A;  2CW0 D;  4FIB A;  1CZ4 A;  1ZC1 A;  2WAQ A;  3MB5 A;  1CZ5 A;  4GA6 A;  3HU1 A;  2JIR A;  4KOD A;  3LGA A;  2JIQ A;  1TWC A;  3X2O A;  2LW6 A;  2YVL A;  1HD5 A;  2VPZ A;  1PQH A;  4KDI A;  1UHD A;  1ZYR D;  2JIP A;  5H4U A;  4C2M A;  3X2H A;  2PWY A;  2NAP A;  3QQ7 A;  5ERG B;  2B25 A;  1PQE A;  2IV2 X;  2V3V A;  3M3G A;  4JP6 A;  3QC8 A;  5GLY A;  5D6X A;  5C1B A;  3OUG A;  2PI8 A;  2JIO A;  1YNN D;  3DMR A;  3FKI A;  2JIM A;  5B6C A;  2PIC A;  1E32 A;  3GTM A;  4KDL A;  3GTO A;  3ML1 A;  1AW8 B;  1SMY D;  4JP7 A;  3BQB A;  4ARI A;  1FDO A;  2YU9 A;  2BE5 D;  3SUM A;  4AON B;  2GFA A;  1PYU B;  1Y4Z A;  1WC2 A;  4QIW A;  1PQF A;  3ZJT A; 
#chains in the Genus database with same CATH homology
 4UC4 A;  3CF2 A;  1TWG A;  2Q18 X;  4CRZ A;  1H5N A;  1YLE A;  1PT0 A;  3FPU A;  3H0G A;  2WB1 A;  3GTL A;  1KQG A;  2Q1D X;  4CS0 A;  2O5J D;  2GAE A;  2VPY A;  1TWF A;  2PNW A;  1DMS A;  2G5D A;  2MM0 A;  3FPT A;  5FTM A;  3HU3 A;  1R27 A;  4AOK B;  1Y1W A;  2Q1A X;  3CZB A;  3PLX B;  2VPX A;  2V45 A;  3CQZ A;  3QQ8 A;  5DYI A;  5CCX A;  2PJJ A;  2VUM A;  3HU2 A;  2JV2 A;  1I50 A;  1WLF A;  1Q16 A;  2Q19 X;  1H0H A;  1S3S A;  1TMO A;  1UHE A;  2EEO B;  4AAY A;  3O5A A;  4AQ7 A;  2QQR A;  1CR5 A;  1PT1 A;  1SFO A;  4CRY G;  5D6W A;  1TWA A;  3LHD A;  5FTJ A;  2NYA A;  2R7Z A;  3GTP A;  2B63 A;  3GTQ A;  2E2H A;  3ZGZ A;  1G8K A;  4CQN A;  1E5V A;  1DMR A;  4AYB A;  1TWH A;  1FDI A;  5FTL A;  2NVY A;  1I3Q A;  2Q1C X;  4AS1 A;  2R93 A;  1E61 A;  2A69 D;  2A6E D;  1I9G A;  1OGY A;  4KLN A;  3TM7 B;  1O54 A;  5FTK A;  3GTK A;  1Y5I A;  3IR6 A;  2NVX A;  3FPR A;  5FTN A;  2KY9 A;  5EQJ B;  2C45 A;  3IR7 A;  2JA5 A;  2YUJ A;  1EU1 A;  2Y0S A;  1AA6 A;  4ARC A;  2MM2 A;  1E60 A;  2E7Z A;  2A6H D;  2JA7 A;  5T5M D;  3ZJU A;  1YNJ D;  2QQS A;  1WCM A;  1PPY A;  3QWZ A;  5DYG A;  5CCB A;  4RV0 A;  4AZD A;  3IR5 A;  5C18 A;  1VC3 B;  2VPW A;  2DMR A;  2A68 D;  1IW7 D;  2XDP A;  2KI8 A;  5GLF A;  2R92 A;  3ZJV A;  2GF7 A;  1K83 A;  1E18 A;  1R9T A;  2G6G A;  2E2I A;  2AE0 X;  5CD1 A;  5D6Y A;  1PYQ A;  1KQF A;  5T5I D;  3TIW A;  1Y1V A;  3HKZ A;  1QDN A;  5EPP A;  4D7Z B;  2PMZ A;  2JA6 A;  1QCS A;  3GTG A;  4KO8 A;  1G8J A;  1R7R A;  1SIW A;  4GA5 A;  3GTJ A;  2PJH B;  4DMR A;  2CW0 D;  4FIB A;  1CZ4 A;  1ZC1 A;  2WAQ A;  3MB5 A;  1CZ5 A;  4GA6 A;  3HU1 A;  2JIR A;  4KOD A;  3LGA A;  2JIQ A;  1TWC A;  2LW6 A;  2YVL A;  2VPZ A;  1PQH A;  4KDI A;  1UHD A;  1ZYR D;  2JIP A;  4C2M A;  2PWY A;  5ERG B;  2NAP A;  3QQ7 A;  2B25 A;  1PQE A;  2IV2 X;  2V3V A;  3QC8 A;  5D6X A;  5C1B A;  3OUG A;  2PI8 A;  2JIO A;  1YNN D;  3DMR A;  3FKI A;  2JIM A;  5B6C A;  2PIC A;  1E32 A;  3GTM A;  4KDL A;  3GTO A;  3ML1 A;  1AW8 B;  1SMY D;  3BQB A;  4ARI A;  1FDO A;  2YU9 A;  2BE5 D;  2GFA A;  4AON B;  1PYU B;  1Y4Z A;  4NOH A;  4QIW A;  1PQF A;  3ZJT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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