5GLFA

Structural insights into the interaction of p97 n-terminal domain and shp motif in derlin-1 rhomboid pseudoprotease
Total Genus 48
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
48
sequence length
170
structure length
170
Chain Sequence
PNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the interaction of human p97 N-terminal domain and SHP motif in Derlin-1 rhomboid pseudoprotease.
pubmed doi rcsb
molecule tags Hydrolase/transport protein
source organism Homo sapiens
molecule keywords Transitional endoplasmic reticulum ATPase
total genus 48
structure length 170
sequence length 170
chains with identical sequence C, E, G
ec nomenclature ec 3.6.4.6: Vesicle-fusing ATPase.
pdb deposition date 2016-07-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02359 CDC48_N Cell division protein 48 (CDC48), N-terminal domain
A PF02933 CDC48_2 Cell division protein 48 (CDC48), domain 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases Barwin-like endoglucanases 5glfA01
3.10.330.10 Alpha Beta Roll Vcp-like ATPase; Chain A, domain 2 Vcp-like ATPase; Chain A, domain 2 5glfA02
3O5AA 4AOKB 1PQEA 4CRZA 2JV2A 5T5ID 4CRYG 4DMRA 2E2HA 1PYUB 1TWGA 2YU9A 4RV0A 1R7RA 1Y4ZA 2V3VA 4CS0A 3GTKA 5FTMA 2JIQA 3QC8A 5C1BA 2VPZA 1SIWA 1PQFA 1TWFA 1UHDA 1Y5IA 4AAYA 1WLFA 2KI8A 3GTOA 2PMZA 5FTNA 2EEOB 1PQHA 4KO8A 1YLEA 2VPYA 5FTKA 1DMRA 2V45A 1E60A 5DYIA 5C18A 3GTPA 2JIPA 1I3QA 1VC3B 1KQFA 3H0GA 3IR6A 1S3SA 4KODA 5T5MD 1CZ5A 2JA5A 3QWZA 2VPXA 1TWHA 1Y1VA 1TWAA 1E18A 3GTGA 2NAPA 3OUGA 2NVXA 4C2MA 1AA6A 3PLXB 1KQGA 1R27A 4GA5A 3GTQA 1FDOA 2JA6A 2B63A 3IR5A 2JA7A 2NVYA 2IV2X 1SFOA 1H5NA 3FKIA 2R7ZA 4AONB 3HU3A 3QQ7A 3ML1A 1E5VA 3HU2A 3GTMA 4KLNA 3QQ8A 1PT1A 1IW7D 2VPWA 1G8KA 2WAQA 4KDLA 2VUMA 4KDIA 1FDIA 1I50A 1AW8B 2E7ZA 3DMRA 1H0HA 5GLFA 3GTJA 1QCSA 2JIRA 1EU1A 3IR7A 1PT0A 2JIOA 1CZ4A 3HKZA 4QIWA 2R93A 4GA6A 1ZC1A 3TIWA 1R9TA 1PYQA 5DYGA 5FTLA 2R92A 1Y1WA 2YUJA 5FTJA 2WB1A 2C45A 2DMRA 3HU1A 4AZDA 1UHEA 1WCMA 1QDNA 5B6CA 1CR5A 4D7ZB 1E61A 4AYBA 3CF2A 3TM7B 2E2IA 1Q16A 2JIMA 1PPYA 1DMSA 5EPPA 1E32A 1K83A 3GTLA 2PJHB 1OGYA 1TWCA 2NYAA 1G8JA 2Y0SA 3CQZA 1TMOA
chains in the Genus database with same CATH superfamily
1N10A 4JP6A 3O5AA 4AOKB 1BW3A 3X2MA 1PQEA 4CRZA 2JV2A 2Q1DX 5ERGB 5T5ID 2A68D 4CRYG 4DMRA 3ZJUA 2E2HA 5GM9A 1I9GA 1ZYRD 5CD1A 1PYUB 1TWGA 2G5DA 2HCZX 2YU9A 4RV0A 1OA9A 3ZJVA 1R7RA 1Y4ZA 2V3VA 4CS0A 1YNND 2GF7A 5H4UA 2GFAA 3GTKA 3ZGZA 5FTMA 2JIQA 3QC8A 2MM0A 2XDPA 4AVRA 5C1BA 4CQNA 3X2OA 2VPZA 3X2HA 4UC4A 3X2KA 5CCBA 2PICA 2PNWA 1SIWA 1PQFA 1TWFA 3X2JA 5D6XA 1UHDA 1Y5IA 3LGAA 4FG2A 4AS1A 4AAYA 1WLFA 2KI8A 3GTOA 2PMZA 5FTNA 2EEOB 1PQHA 4KO8A 1YLEA 2VPYA 3LHDA 5FTKA 1DMRA 4JP7A 2V45A 1E60A 2O5JD 3SUMA 5DYIA 4FG4A 3ZJTA 5CCXA 5C18A 3GTPA 2JIPA 1I3QA 1VC3B 1KQFA 2QQRA 3H0GA 3IR6A 3FPUA 1S3SA 4KODA 5T5MD 4FERA 2JA5A 3QWZA 1HD5A 2VPXA 1CZ5A 2Q18X 3FPTA 2BH0A 3X2GA 1TWHA 1Y1VA 1TWAA 1E18A 4ARIA 2QQSA 3GTGA 3X2IA 2NAPA 3OUGA 4ENGA 2NVXA 4C2MA 1AA6A 2CW0D 2PI8A 3PLXB 1KQGA 1R27A 4JS7A 4GA5A 1BW4A 2A69D 3GTQA 1FDOA 5D6YA 2JA6A 2A6HD 2B63A 3IR5A 2JA7A 2NVYA 2IV2X 1SFOA 1H5NA 3FKIA 2PWYA 2R7ZA 4AONB 3HU3A 3QQ7A 2Q1CX 3ML1A 4ARCA 1E5VA 1WC2A 3HU2A 3GTMA 4KLNA 1L8FA 3QQ8A 1PT1A 1IW7D 2VPWA 4AQ7A 1G8KA 2WAQA 2AE0X 2A6ED 3M3GA 4KDLA 1SMYD 2VUMA 3D30A 3ENGA 4KDIA 2B25A 1FDIA 1I50A 4JJOA 3CZBA 1AW8B 1O54A 2E7ZA 2BE5D 3DMRA 1H0HA 4FFTA 3X2PA 2KQAA 2Q1AX 2YVLA 5GLFA 3GTJA 2PJJA 1QCSA 2JIRA 1EU1A 3IR7A 1PT0A 2JIOA 1CZ4A 1ZC1A 3HKZA 4QIWA 4GA6A 3SUKA 2R93A 3TIWA 3FPRA 1R9TA 1PYQA 5DYGA 3SUJA 5FTLA 2R92A 1Y1WA 2YUJA 5D6WA 2MM2A 5FTJA 2KY9A 2WB1A 3SULA 2C45A 3MB5A 2DMRA 3HU1A 4AZDA 1UHEA 1WCMA 1QDNA 5GLXA 5B6CA 1CR5A 3X2LA 1E61A 4AYBA 3CF2A 3TM7B 4D7ZB 2LW6A 2E2IA 5GLYA 1Q16A 2JIMA 1PPYA 1DMSA 5EPPA 1E32A 1K83A 5EQJB 4L48A 2G6GA 3GTLA 2PJHB 4NOHA 1OGYA 2ENGA 1TWCA 2NYAA 3BQBA 1G8JA 2Y0SA 2GAEA 4JCWA 3CQZA 1TMOA 3X2NA 1YNJD 4FIBA 1OA7A 2Q19X 4ZM7A
chains in the Genus database with same CATH topology
3O5AA 4AOKB 1PQEA 4CRZA 2JV2A 2Q1DX 5ERGB 5T5ID 2A68D 4CRYG 4DMRA 3ZJUA 2E2HA 1I9GA 1ZYRD 1PYUB 1TWGA 2G5DA 2YU9A 3ZJVA 4RV0A 1R7RA 1Y4ZA 2V3VA 4CS0A 1YNND 2GF7A 2GFAA 3GTKA 3ZGZA 5FTMA 2JIQA 3QC8A 2MM0A 2XDPA 5C1BA 4CQNA 2VPZA 4UC4A 5CCBA 2PICA 2PNWA 1SIWA 1PQFA 1TWFA 5D6XA 1UHDA 1Y5IA 3LGAA 4AS1A 4AAYA 1WLFA 2KI8A 3GTOA 2PMZA 5FTNA 2EEOB 1PQHA 4KO8A 1YLEA 2VPYA 3LHDA 5FTKA 1DMRA 2V45A 1E60A 2O5JD 5DYIA 3ZJTA 5CCXA 5C18A 3GTPA 2JIPA 1I3QA 1VC3B 1KQFA 2QQRA 3H0GA 3IR6A 3FPUA 1S3SA 4KODA 5T5MD 1CZ5A 2JA5A 3QWZA 2Q18X 2VPXA 3FPTA 1TWHA 1Y1VA 1TWAA 1E18A 4ARIA 2QQSA 3GTGA 2NAPA 3OUGA 2NVXA 4C2MA 1AA6A 2CW0D 2PI8A 3PLXB 1KQGA 1R27A 4GA5A 2A69D 3GTQA 1FDOA 5D6YA 2JA6A 2A6HD 2B63A 3IR5A 2JA7A 2NVYA 2IV2X 1SFOA 1H5NA 3FKIA 2PWYA 2R7ZA 4AONB 3HU3A 3QQ7A 2Q1CX 3ML1A 4ARCA 1E5VA 3HU2A 3GTMA 4KLNA 3QQ8A 1PT1A 1IW7D 2VPWA 4AQ7A 1G8KA 2WAQA 2AE0X 2A6ED 4KDLA 1SMYD 2VUMA 4KDIA 2B25A 1FDIA 1I50A 3CZBA 1AW8B 1O54A 2E7ZA 2BE5D 3DMRA 1H0HA 2Q1AX 2YVLA 5GLFA 3GTJA 2PJJA 1QCSA 2JIRA 1EU1A 3IR7A 1PT0A 2JIOA 1CZ4A 1ZC1A 3HKZA 4QIWA 4GA6A 2R93A 5CD1A 3TIWA 3FPRA 1R9TA 1PYQA 5DYGA 5FTLA 2R92A 1Y1WA 5D6WA 2YUJA 5FTJA 2KY9A 2WB1A 2C45A 3MB5A 2DMRA 3HU1A 4AZDA 1UHEA 1WCMA 1QDNA 5B6CA 1CR5A 4D7ZB 1E61A 4AYBA 3CF2A 3TM7B 2LW6A 2E2IA 1Q16A 2JIMA 1PPYA 1DMSA 5EPPA 1E32A 1K83A 5EQJB 3GTLA 2G6GA 2PJHB 4NOHA 1OGYA 1TWCA 2NYAA 3BQBA 1G8JA 2Y0SA 2GAEA 3CQZA 1TMOA 1YNJD 4FIBA 2MM2A 2Q19X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3O5A A;  4AOK B;  1PQE A;  4CRZ A;  2JV2 A;  5T5I D;  4CRY G;  4DMR A;  2E2H A;  1PYU B;  1TWG A;  2YU9 A;  4RV0 A;  1R7R A;  1Y4Z A;  2V3V A;  4CS0 A;  3GTK A;  5FTM A;  2JIQ A;  3QC8 A;  5C1B A;  2VPZ A;  1SIW A;  1PQF A;  1TWF A;  1UHD A;  1Y5I A;  4AAY A;  1WLF A;  2KI8 A;  3GTO A;  2PMZ A;  5FTN A;  2EEO B;  1PQH A;  4KO8 A;  1YLE A;  2VPY A;  5FTK A;  1DMR A;  2V45 A;  1E60 A;  5DYI A;  5C18 A;  3GTP A;  2JIP A;  1I3Q A;  1VC3 B;  1KQF A;  3H0G A;  3IR6 A;  1S3S A;  4KOD A;  5T5M D;  1CZ5 A;  2JA5 A;  3QWZ A;  2VPX A;  1TWH A;  1Y1V A;  1TWA A;  1E18 A;  3GTG A;  2NAP A;  3OUG A;  2NVX A;  4C2M A;  1AA6 A;  3PLX B;  1KQG A;  1R27 A;  4GA5 A;  3GTQ A;  1FDO A;  2JA6 A;  2B63 A;  3IR5 A;  2JA7 A;  2NVY A;  2IV2 X;  1SFO A;  1H5N A;  3FKI A;  2R7Z A;  4AON B;  3HU3 A;  3QQ7 A;  3ML1 A;  1E5V A;  3HU2 A;  3GTM A;  4KLN A;  3QQ8 A;  1PT1 A;  1IW7 D;  2VPW A;  1G8K A;  2WAQ A;  4KDL A;  2VUM A;  4KDI A;  1FDI A;  1I50 A;  1AW8 B;  2E7Z A;  3DMR A;  1H0H A;  5GLF A;  3GTJ A;  1QCS A;  2JIR A;  1EU1 A;  3IR7 A;  1PT0 A;  2JIO A;  1CZ4 A;  3HKZ A;  4QIW A;  2R93 A;  4GA6 A;  1ZC1 A;  3TIW A;  1R9T A;  1PYQ A;  5DYG A;  5FTL A;  2R92 A;  1Y1W A;  2YUJ A;  5FTJ A;  2WB1 A;  2C45 A;  2DMR A;  3HU1 A;  4AZD A;  1UHE A;  1WCM A;  1QDN A;  5B6C A;  1CR5 A;  4D7Z B;  1E61 A;  4AYB A;  3CF2 A;  3TM7 B;  2E2I A;  1Q16 A;  2JIM A;  1PPY A;  1DMS A;  5EPP A;  1E32 A;  1K83 A;  3GTL A;  2PJH B;  1OGY A;  1TWC A;  2NYA A;  1G8J A;  2Y0S A;  3CQZ A;  1TMO A; 
#chains in the Genus database with same CATH topology
 1N10 A;  4JP6 A;  3O5A A;  4AOK B;  1BW3 A;  3X2M A;  1PQE A;  4CRZ A;  2JV2 A;  2Q1D X;  5ERG B;  5T5I D;  2A68 D;  4CRY G;  4DMR A;  3ZJU A;  2E2H A;  5GM9 A;  1I9G A;  1ZYR D;  5CD1 A;  1PYU B;  1TWG A;  2G5D A;  2HCZ X;  2YU9 A;  4RV0 A;  1OA9 A;  3ZJV A;  1R7R A;  1Y4Z A;  2V3V A;  4CS0 A;  1YNN D;  2GF7 A;  5H4U A;  2GFA A;  3GTK A;  3ZGZ A;  5FTM A;  2JIQ A;  3QC8 A;  2MM0 A;  2XDP A;  4AVR A;  5C1B A;  4CQN A;  3X2O A;  2VPZ A;  3X2H A;  4UC4 A;  3X2K A;  5CCB A;  2PIC A;  2PNW A;  1SIW A;  1PQF A;  1TWF A;  3X2J A;  5D6X A;  1UHD A;  1Y5I A;  3LGA A;  4FG2 A;  4AS1 A;  4AAY A;  1WLF A;  2KI8 A;  3GTO A;  2PMZ A;  5FTN A;  2EEO B;  1PQH A;  4KO8 A;  1YLE A;  2VPY A;  3LHD A;  5FTK A;  1DMR A;  4JP7 A;  2V45 A;  1E60 A;  2O5J D;  3SUM A;  5DYI A;  4FG4 A;  3ZJT A;  5CCX A;  5C18 A;  3GTP A;  2JIP A;  1I3Q A;  1VC3 B;  1KQF A;  2QQR A;  3H0G A;  3IR6 A;  3FPU A;  1S3S A;  4KOD A;  5T5M D;  4FER A;  2JA5 A;  3QWZ A;  1HD5 A;  2VPX A;  1CZ5 A;  2Q18 X;  3FPT A;  2BH0 A;  3X2G A;  1TWH A;  1Y1V A;  1TWA A;  1E18 A;  4ARI A;  2QQS A;  3GTG A;  3X2I A;  2NAP A;  3OUG A;  4ENG A;  2NVX A;  4C2M A;  1AA6 A;  2CW0 D;  2PI8 A;  3PLX B;  1KQG A;  1R27 A;  4JS7 A;  4GA5 A;  1BW4 A;  2A69 D;  3GTQ A;  1FDO A;  5D6Y A;  2JA6 A;  2A6H D;  2B63 A;  3IR5 A;  2JA7 A;  2NVY A;  2IV2 X;  1SFO A;  1H5N A;  3FKI A;  2PWY A;  2R7Z A;  4AON B;  3HU3 A;  3QQ7 A;  2Q1C X;  3ML1 A;  4ARC A;  1E5V A;  1WC2 A;  3HU2 A;  3GTM A;  4KLN A;  1L8F A;  3QQ8 A;  1PT1 A;  1IW7 D;  2VPW A;  4AQ7 A;  1G8K A;  2WAQ A;  2AE0 X;  2A6E D;  3M3G A;  4KDL A;  1SMY D;  2VUM A;  3D30 A;  3ENG A;  4KDI A;  2B25 A;  1FDI A;  1I50 A;  4JJO A;  3CZB A;  1AW8 B;  1O54 A;  2E7Z A;  2BE5 D;  3DMR A;  1H0H A;  4FFT A;  3X2P A;  2KQA A;  2Q1A X;  2YVL A;  5GLF A;  3GTJ A;  2PJJ A;  1QCS A;  2JIR A;  1EU1 A;  3IR7 A;  1PT0 A;  2JIO A;  1CZ4 A;  1ZC1 A;  3HKZ A;  4QIW A;  4GA6 A;  3SUK A;  2R93 A;  3TIW A;  3FPR A;  1R9T A;  1PYQ A;  5DYG A;  3SUJ A;  5FTL A;  2R92 A;  1Y1W A;  2YUJ A;  5D6W A;  2MM2 A;  5FTJ A;  2KY9 A;  2WB1 A;  3SUL A;  2C45 A;  3MB5 A;  2DMR A;  3HU1 A;  4AZD A;  1UHE A;  1WCM A;  1QDN A;  5GLX A;  5B6C A;  1CR5 A;  3X2L A;  1E61 A;  4AYB A;  3CF2 A;  3TM7 B;  4D7Z B;  2LW6 A;  2E2I A;  5GLY A;  1Q16 A;  2JIM A;  1PPY A;  1DMS A;  5EPP A;  1E32 A;  1K83 A;  5EQJ B;  4L48 A;  2G6G A;  3GTL A;  2PJH B;  4NOH A;  1OGY A;  2ENG A;  1TWC A;  2NYA A;  3BQB A;  1G8J A;  2Y0S A;  2GAE A;  4JCW A;  3CQZ A;  1TMO A;  3X2N A;  1YNJ D;  4FIB A;  1OA7 A;  2Q19 X;  4ZM7 A; 
#chains in the Genus database with same CATH homology
 3O5A A;  4AOK B;  1PQE A;  4CRZ A;  2JV2 A;  2Q1D X;  5ERG B;  5T5I D;  2A68 D;  4CRY G;  4DMR A;  3ZJU A;  2E2H A;  1I9G A;  1ZYR D;  1PYU B;  1TWG A;  2G5D A;  2YU9 A;  3ZJV A;  4RV0 A;  1R7R A;  1Y4Z A;  2V3V A;  4CS0 A;  1YNN D;  2GF7 A;  2GFA A;  3GTK A;  3ZGZ A;  5FTM A;  2JIQ A;  3QC8 A;  2MM0 A;  2XDP A;  5C1B A;  4CQN A;  2VPZ A;  4UC4 A;  5CCB A;  2PIC A;  2PNW A;  1SIW A;  1PQF A;  1TWF A;  5D6X A;  1UHD A;  1Y5I A;  3LGA A;  4AS1 A;  4AAY A;  1WLF A;  2KI8 A;  3GTO A;  2PMZ A;  5FTN A;  2EEO B;  1PQH A;  4KO8 A;  1YLE A;  2VPY A;  3LHD A;  5FTK A;  1DMR A;  2V45 A;  1E60 A;  2O5J D;  5DYI A;  3ZJT A;  5CCX A;  5C18 A;  3GTP A;  2JIP A;  1I3Q A;  1VC3 B;  1KQF A;  2QQR A;  3H0G A;  3IR6 A;  3FPU A;  1S3S A;  4KOD A;  5T5M D;  1CZ5 A;  2JA5 A;  3QWZ A;  2Q18 X;  2VPX A;  3FPT A;  1TWH A;  1Y1V A;  1TWA A;  1E18 A;  4ARI A;  2QQS A;  3GTG A;  2NAP A;  3OUG A;  2NVX A;  4C2M A;  1AA6 A;  2CW0 D;  2PI8 A;  3PLX B;  1KQG A;  1R27 A;  4GA5 A;  2A69 D;  3GTQ A;  1FDO A;  5D6Y A;  2JA6 A;  2A6H D;  2B63 A;  3IR5 A;  2JA7 A;  2NVY A;  2IV2 X;  1SFO A;  1H5N A;  3FKI A;  2PWY A;  2R7Z A;  4AON B;  3HU3 A;  3QQ7 A;  2Q1C X;  3ML1 A;  4ARC A;  1E5V A;  3HU2 A;  3GTM A;  4KLN A;  3QQ8 A;  1PT1 A;  1IW7 D;  2VPW A;  4AQ7 A;  1G8K A;  2WAQ A;  2AE0 X;  2A6E D;  4KDL A;  1SMY D;  2VUM A;  4KDI A;  2B25 A;  1FDI A;  1I50 A;  3CZB A;  1AW8 B;  1O54 A;  2E7Z A;  2BE5 D;  3DMR A;  1H0H A;  2Q1A X;  2YVL A;  5GLF A;  3GTJ A;  2PJJ A;  1QCS A;  2JIR A;  1EU1 A;  3IR7 A;  1PT0 A;  2JIO A;  1CZ4 A;  1ZC1 A;  3HKZ A;  4QIW A;  4GA6 A;  2R93 A;  5CD1 A;  3TIW A;  3FPR A;  1R9T A;  1PYQ A;  5DYG A;  5FTL A;  2R92 A;  1Y1W A;  5D6W A;  2YUJ A;  5FTJ A;  2KY9 A;  2WB1 A;  2C45 A;  3MB5 A;  2DMR A;  3HU1 A;  4AZD A;  1UHE A;  1WCM A;  1QDN A;  5B6C A;  1CR5 A;  4D7Z B;  1E61 A;  4AYB A;  3CF2 A;  3TM7 B;  2LW6 A;  2E2I A;  1Q16 A;  2JIM A;  1PPY A;  1DMS A;  5EPP A;  1E32 A;  1K83 A;  5EQJ B;  3GTL A;  2G6G A;  2PJH B;  4NOH A;  1OGY A;  1TWC A;  2NYA A;  3BQB A;  1G8J A;  2Y0S A;  2GAE A;  3CQZ A;  1TMO A;  1YNJ D;  4FIB A;  2MM2 A;  2Q19 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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