5EPPA

Structural insights into the interaction of p97 n-terminus domain and vbm motif in rhomboid protease, rhbdl4
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
170
structure length
170
Chain Sequence
NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Transitional endoplasmic reticulum ATPase
total genus 46
structure length 170
sequence length 170
ec nomenclature ec 3.6.4.6: Vesicle-fusing ATPase.
pdb deposition date 2015-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02359 CDC48_N Cell division protein 48 (CDC48), N-terminal domain
A PF02933 CDC48_2 Cell division protein 48 (CDC48), domain 2
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.40.20 Mainly Beta Beta Barrel Barwin-like endoglucanases Barwin-like endoglucanases 5eppA01
3.10.330.10 Alpha Beta Roll Vcp-like ATPase; Chain A, domain 2 Vcp-like ATPase; Chain A, domain 2 5eppA02
4CS0A 3DMRA 2JV2A 1Y4ZA 1E32A 1S3SA 3IR5A 1PQEA 2JIPA 2VPWA 3GTJA 4C2MA 4QIWA 3HU2A 2C45A 1E60A 2KI8A 3CQZA 3H0GA 1PQHA 4CRYG 1TWGA 3CF2A 3GTGA 3PLXB 3GTPA 1Y5IA 2V45A 1E61A 2B63A 2IV2X 2JA7A 2JIOA 1YLEA 5GLFA 3GTLA 1H0HA 2JIRA 2VPYA 3IR7A 1R27A 2YU9A 3QQ8A 1IW7D 2JIQA 1TMOA 5FTLA 5FTMA 3IR6A 5EPPA 5T5ID 2DMRA 5DYIA 2JA6A 4KDLA 1AA6A 4CRZA 1PT1A 1I50A 1E18A 1G8JA 1Y1VA 1WLFA 5B6CA 1SFOA 1KQGA 1OGYA 2E7ZA 2WB1A 5C18A 5FTJA 1G8KA 1EU1A 2VPZA 3OUGA 1CZ4A 4RV0A 1PPYA 3GTMA 1QDNA 1PT0A 2E2IA 2JIMA 1TWFA 2VUMA 5FTNA 4GA6A 5C1BA 1CZ5A 1I3QA 3QC8A 2VPXA 1E5VA 5T5MD 3TIWA 4AOKB 1PQFA 4AZDA 4GA5A 4KDIA 4D7ZB 2YUJA 4AYBA 3GTOA 1TWAA 4KLNA 2E2HA 2NYAA 2NAPA 5DYGA 2R7ZA 1AW8B 2PMZA 1Y1WA 2V3VA 1H5NA 1DMRA 4KODA 4AAYA 1TWCA 1DMSA 1TWHA 2NVYA 4DMRA 1KQFA 2EEOB 3HU1A 3HKZA 1K83A 1R9TA 1UHEA 1FDOA 1Q16A 3ML1A 1PYUB 2PJHB 1SIWA 1FDIA 3FKIA 4KO8A 1PYQA 1UHDA 3GTKA 2R92A 1VC3B 1R7RA 1WCMA 3HU3A 2WAQA 5FTKA 3QWZA 1CR5A 3TM7B 2NVXA 3GTQA 2R93A 2Y0SA 3O5AA 2JA5A 1QCSA 3QQ7A 4AONB 1ZC1A
chains in the Genus database with same CATH superfamily
4CS0A 3DMRA 2JV2A 2HCZX 1Y4ZA 1E32A 4FG2A 1BW3A 1S3SA 2A68D 3IR5A 2GF7A 1PQEA 2Q19X 2JIPA 3SUJA 2PWYA 2VPWA 1YNJD 3GTJA 3SULA 4C2MA 4QIWA 3HU2A 2C45A 1E60A 3MB5A 2KI8A 1ZYRD 4UC4A 3CQZA 3H0GA 3CZBA 5GLYA 1PQHA 4CRYG 1TWGA 2PJJA 3CF2A 3PLXB 3GTGA 3GTPA 2PI8A 3LGAA 1Y5IA 5CCXA 2V45A 1E61A 2B63A 2IV2X 4AVRA 2JA7A 2XDPA 5ERGB 2JIOA 1O54A 1YLEA 5GLFA 2BE5D 3GTLA 1H0HA 3ZJVA 2JIRA 2VPYA 5D6WA 3IR7A 1R27A 2YU9A 2BH0A 3QQ8A 3X2OA 4AS1A 1IW7D 2JIQA 1TMOA 4JS7A 5FTLA 5FTMA 5EQJB 1L8FA 3IR6A 2QQRA 2Q1CX 5EPPA 5T5ID 2DMRA 5DYIA 2JA6A 4KDLA 1AA6A 2O5JD 4CRZA 1PT1A 1SMYD 1I50A 1E18A 1G8JA 4FIBA 3ZJUA 2GAEA 1Y1VA 1WLFA 5B6CA 1SFOA 1KQGA 4JP6A 1OGYA 2E7ZA 3X2MA 2WB1A 4L48A 5C18A 5FTJA 1G8KA 2A6HD 5GM9A 1EU1A 2GFAA 4ZM7A 2KQAA 3SUKA 1OA9A 2VPZA 3OUGA 1CZ4A 4RV0A 1PPYA 3GTMA 1QDNA 1PT0A 2E2IA 2JIMA 2Q1AX 1TWFA 2VUMA 5FTNA 4FERA 4GA6A 3SUMA 5C1BA 1CZ5A 2A6ED 3X2NA 3QC8A 2VPXA 3X2GA 1I3QA 3M3GA 2MM2A 1E5VA 5T5MD 3TIWA 4AOKB 1PQFA 2AE0X 4AZDA 3X2IA 4GA5A 4KDIA 2YUJA 4D7ZB 4CQNA 2Q18X 4AYBA 3X2PA 1WC2A 1TWAA 4KLNA 3GTOA 2E2HA 2NYAA 2NAPA 2KY9A 2LW6A 5DYGA 2R7ZA 3X2JA 1AW8B 2PNWA 2B25A 2PMZA 1Y1WA 2CW0D 2V3VA 5D6YA 1H5NA 4FG4A 4ENGA 4JJOA 3BQBA 1DMRA 1N10A 4KODA 2G5DA 2ENGA 4AAYA 1TWCA 5D6XA 2MM0A 1DMSA 1TWHA 5H4UA 3D30A 3FPUA 2NVYA 4DMRA 1KQFA 2EEOB 4FFTA 1HD5A 3HU1A 3X2KA 5CCBA 3HKZA 1K83A 1R9TA 1UHEA 1FDOA 1BW4A 4ARCA 2PICA 1Q16A 3ML1A 4AQ7A 1PYUB 3FPRA 3ZGZA 1I9GA 2PJHB 1SIWA 1FDIA 5GLXA 3ZJTA 1YNND 2Q1DX 3X2HA 5CD1A 3FKIA 4KO8A 1PYQA 1UHDA 3GTKA 2R92A 2QQSA 1VC3B 2G6GA 1R7RA 1WCMA 3HU3A 3X2LA 3LHDA 4ARIA 2A69D 4NOHA 2WAQA 5FTKA 3ENGA 3QWZA 1CR5A 3TM7B 2NVXA 4JCWA 3GTQA 3FPTA 2YVLA 4JP7A 2Y0SA 3O5AA 2R93A 2JA5A 1OA7A 1QCSA 3QQ7A 4AONB 1ZC1A
chains in the Genus database with same CATH topology
4CS0A 3DMRA 2JV2A 1Y4ZA 1E32A 1S3SA 2A68D 3IR5A 2GF7A 1PQEA 2Q19X 2JIPA 2PWYA 2VPWA 1YNJD 3GTJA 4C2MA 4QIWA 3HU2A 2C45A 1E60A 3MB5A 2KI8A 1ZYRD 4UC4A 3CQZA 3H0GA 3CZBA 1PQHA 4CRYG 1TWGA 2PJJA 3CF2A 3PLXB 3GTGA 3GTPA 2PI8A 3LGAA 1Y5IA 5CCXA 2V45A 1E61A 2B63A 2IV2X 2JA7A 2XDPA 5ERGB 2JIOA 1O54A 1YLEA 5GLFA 2BE5D 3GTLA 1H0HA 3ZJVA 2JIRA 2VPYA 5D6WA 3IR7A 1R27A 2YU9A 4AS1A 3QQ8A 1IW7D 2JIQA 1TMOA 5FTLA 5FTMA 5EQJB 3IR6A 2QQRA 2Q1CX 5EPPA 5T5ID 2DMRA 5DYIA 2JA6A 4KDLA 1AA6A 2O5JD 4CRZA 1PT1A 1SMYD 1I50A 1E18A 1G8JA 4FIBA 3ZJUA 2GAEA 1Y1VA 1WLFA 5B6CA 1SFOA 1KQGA 1OGYA 2E7ZA 2WB1A 5C18A 5FTJA 1G8KA 2A6HD 2GFAA 1EU1A 2VPZA 3OUGA 1CZ4A 4RV0A 1PPYA 3GTMA 1QDNA 1PT0A 2E2IA 2JIMA 2Q1AX 1TWFA 2VUMA 5FTNA 4GA6A 5C1BA 1CZ5A 2A6ED 1I3QA 3QC8A 2VPXA 2MM2A 1E5VA 5T5MD 3TIWA 4AOKB 1PQFA 2AE0X 4AZDA 4GA5A 4KDIA 2YUJA 4D7ZB 4CQNA 2Q18X 4AYBA 3GTOA 1TWAA 4KLNA 2E2HA 2KY9A 2LW6A 2NYAA 2NAPA 5DYGA 2R7ZA 1AW8B 2PNWA 2B25A 2PMZA 1Y1WA 2CW0D 2V3VA 5D6YA 1H5NA 3BQBA 1DMRA 4KODA 2G5DA 4AAYA 1TWCA 5D6XA 2MM0A 1DMSA 1TWHA 3FPUA 2NVYA 4DMRA 1KQFA 2EEOB 3HU1A 5CCBA 3HKZA 1K83A 1R9TA 1UHEA 1FDOA 4ARCA 2PICA 1Q16A 3ML1A 4AQ7A 1PYUB 3FPRA 3ZGZA 1I9GA 2PJHB 1SIWA 1FDIA 3ZJTA 1YNND 2Q1DX 5CD1A 3FKIA 4KO8A 1PYQA 1UHDA 3GTKA 2R92A 2QQSA 1VC3B 2G6GA 1R7RA 1WCMA 3HU3A 3LHDA 4ARIA 2A69D 4NOHA 2WAQA 5FTKA 3QWZA 1CR5A 3TM7B 2NVXA 3GTQA 3FPTA 2YVLA 2R93A 2Y0SA 3O5AA 2JA5A 1QCSA 3QQ7A 4AONB 1ZC1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CS0 A;  3DMR A;  2JV2 A;  1Y4Z A;  1E32 A;  1S3S A;  3IR5 A;  1PQE A;  2JIP A;  2VPW A;  3GTJ A;  4C2M A;  4QIW A;  3HU2 A;  2C45 A;  1E60 A;  2KI8 A;  3CQZ A;  3H0G A;  1PQH A;  4CRY G;  1TWG A;  3CF2 A;  3GTG A;  3PLX B;  3GTP A;  1Y5I A;  2V45 A;  1E61 A;  2B63 A;  2IV2 X;  2JA7 A;  2JIO A;  1YLE A;  5GLF A;  3GTL A;  1H0H A;  2JIR A;  2VPY A;  3IR7 A;  1R27 A;  2YU9 A;  3QQ8 A;  1IW7 D;  2JIQ A;  1TMO A;  5FTL A;  5FTM A;  3IR6 A;  5EPP A;  5T5I D;  2DMR A;  5DYI A;  2JA6 A;  4KDL A;  1AA6 A;  4CRZ A;  1PT1 A;  1I50 A;  1E18 A;  1G8J A;  1Y1V A;  1WLF A;  5B6C A;  1SFO A;  1KQG A;  1OGY A;  2E7Z A;  2WB1 A;  5C18 A;  5FTJ A;  1G8K A;  1EU1 A;  2VPZ A;  3OUG A;  1CZ4 A;  4RV0 A;  1PPY A;  3GTM A;  1QDN A;  1PT0 A;  2E2I A;  2JIM A;  1TWF A;  2VUM A;  5FTN A;  4GA6 A;  5C1B A;  1CZ5 A;  1I3Q A;  3QC8 A;  2VPX A;  1E5V A;  5T5M D;  3TIW A;  4AOK B;  1PQF A;  4AZD A;  4GA5 A;  4KDI A;  4D7Z B;  2YUJ A;  4AYB A;  3GTO A;  1TWA A;  4KLN A;  2E2H A;  2NYA A;  2NAP A;  5DYG A;  2R7Z A;  1AW8 B;  2PMZ A;  1Y1W A;  2V3V A;  1H5N A;  1DMR A;  4KOD A;  4AAY A;  1TWC A;  1DMS A;  1TWH A;  2NVY A;  4DMR A;  1KQF A;  2EEO B;  3HU1 A;  3HKZ A;  1K83 A;  1R9T A;  1UHE A;  1FDO A;  1Q16 A;  3ML1 A;  1PYU B;  2PJH B;  1SIW A;  1FDI A;  3FKI A;  4KO8 A;  1PYQ A;  1UHD A;  3GTK A;  2R92 A;  1VC3 B;  1R7R A;  1WCM A;  3HU3 A;  2WAQ A;  5FTK A;  3QWZ A;  1CR5 A;  3TM7 B;  2NVX A;  3GTQ A;  2R93 A;  2Y0S A;  3O5A A;  2JA5 A;  1QCS A;  3QQ7 A;  4AON B;  1ZC1 A; 
#chains in the Genus database with same CATH topology
 4CS0 A;  3DMR A;  2JV2 A;  2HCZ X;  1Y4Z A;  1E32 A;  4FG2 A;  1BW3 A;  1S3S A;  2A68 D;  3IR5 A;  2GF7 A;  1PQE A;  2Q19 X;  2JIP A;  3SUJ A;  2PWY A;  2VPW A;  1YNJ D;  3GTJ A;  3SUL A;  4C2M A;  4QIW A;  3HU2 A;  2C45 A;  1E60 A;  3MB5 A;  2KI8 A;  1ZYR D;  4UC4 A;  3CQZ A;  3H0G A;  3CZB A;  5GLY A;  1PQH A;  4CRY G;  1TWG A;  2PJJ A;  3CF2 A;  3PLX B;  3GTG A;  3GTP A;  2PI8 A;  3LGA A;  1Y5I A;  5CCX A;  2V45 A;  1E61 A;  2B63 A;  2IV2 X;  4AVR A;  2JA7 A;  2XDP A;  5ERG B;  2JIO A;  1O54 A;  1YLE A;  5GLF A;  2BE5 D;  3GTL A;  1H0H A;  3ZJV A;  2JIR A;  2VPY A;  5D6W A;  3IR7 A;  1R27 A;  2YU9 A;  2BH0 A;  3QQ8 A;  3X2O A;  4AS1 A;  1IW7 D;  2JIQ A;  1TMO A;  4JS7 A;  5FTL A;  5FTM A;  5EQJ B;  1L8F A;  3IR6 A;  2QQR A;  2Q1C X;  5EPP A;  5T5I D;  2DMR A;  5DYI A;  2JA6 A;  4KDL A;  1AA6 A;  2O5J D;  4CRZ A;  1PT1 A;  1SMY D;  1I50 A;  1E18 A;  1G8J A;  4FIB A;  3ZJU A;  2GAE A;  1Y1V A;  1WLF A;  5B6C A;  1SFO A;  1KQG A;  4JP6 A;  1OGY A;  2E7Z A;  3X2M A;  2WB1 A;  4L48 A;  5C18 A;  5FTJ A;  1G8K A;  2A6H D;  5GM9 A;  1EU1 A;  2GFA A;  4ZM7 A;  2KQA A;  3SUK A;  1OA9 A;  2VPZ A;  3OUG A;  1CZ4 A;  4RV0 A;  1PPY A;  3GTM A;  1QDN A;  1PT0 A;  2E2I A;  2JIM A;  2Q1A X;  1TWF A;  2VUM A;  5FTN A;  4FER A;  4GA6 A;  3SUM A;  5C1B A;  1CZ5 A;  2A6E D;  3X2N A;  3QC8 A;  2VPX A;  3X2G A;  1I3Q A;  3M3G A;  2MM2 A;  1E5V A;  5T5M D;  3TIW A;  4AOK B;  1PQF A;  2AE0 X;  4AZD A;  3X2I A;  4GA5 A;  4KDI A;  2YUJ A;  4D7Z B;  4CQN A;  2Q18 X;  4AYB A;  3X2P A;  1WC2 A;  1TWA A;  4KLN A;  3GTO A;  2E2H A;  2NYA A;  2NAP A;  2KY9 A;  2LW6 A;  5DYG A;  2R7Z A;  3X2J A;  1AW8 B;  2PNW A;  2B25 A;  2PMZ A;  1Y1W A;  2CW0 D;  2V3V A;  5D6Y A;  1H5N A;  4FG4 A;  4ENG A;  4JJO A;  3BQB A;  1DMR A;  1N10 A;  4KOD A;  2G5D A;  2ENG A;  4AAY A;  1TWC A;  5D6X A;  2MM0 A;  1DMS A;  1TWH A;  5H4U A;  3D30 A;  3FPU A;  2NVY A;  4DMR A;  1KQF A;  2EEO B;  4FFT A;  1HD5 A;  3HU1 A;  3X2K A;  5CCB A;  3HKZ A;  1K83 A;  1R9T A;  1UHE A;  1FDO A;  1BW4 A;  4ARC A;  2PIC A;  1Q16 A;  3ML1 A;  4AQ7 A;  1PYU B;  3FPR A;  3ZGZ A;  1I9G A;  2PJH B;  1SIW A;  1FDI A;  5GLX A;  3ZJT A;  1YNN D;  2Q1D X;  3X2H A;  5CD1 A;  3FKI A;  4KO8 A;  1PYQ A;  1UHD A;  3GTK A;  2R92 A;  2QQS A;  1VC3 B;  2G6G A;  1R7R A;  1WCM A;  3HU3 A;  3X2L A;  3LHD A;  4ARI A;  2A69 D;  4NOH A;  2WAQ A;  5FTK A;  3ENG A;  3QWZ A;  1CR5 A;  3TM7 B;  2NVX A;  4JCW A;  3GTQ A;  3FPT A;  2YVL A;  4JP7 A;  2Y0S A;  3O5A A;  2R93 A;  2JA5 A;  1OA7 A;  1QCS A;  3QQ7 A;  4AON B;  1ZC1 A; 
#chains in the Genus database with same CATH homology
 4CS0 A;  3DMR A;  2JV2 A;  1Y4Z A;  1E32 A;  1S3S A;  2A68 D;  3IR5 A;  2GF7 A;  1PQE A;  2Q19 X;  2JIP A;  2PWY A;  2VPW A;  1YNJ D;  3GTJ A;  4C2M A;  4QIW A;  3HU2 A;  2C45 A;  1E60 A;  3MB5 A;  2KI8 A;  1ZYR D;  4UC4 A;  3CQZ A;  3H0G A;  3CZB A;  1PQH A;  4CRY G;  1TWG A;  2PJJ A;  3CF2 A;  3PLX B;  3GTG A;  3GTP A;  2PI8 A;  3LGA A;  1Y5I A;  5CCX A;  2V45 A;  1E61 A;  2B63 A;  2IV2 X;  2JA7 A;  2XDP A;  5ERG B;  2JIO A;  1O54 A;  1YLE A;  5GLF A;  2BE5 D;  3GTL A;  1H0H A;  3ZJV A;  2JIR A;  2VPY A;  5D6W A;  3IR7 A;  1R27 A;  2YU9 A;  4AS1 A;  3QQ8 A;  1IW7 D;  2JIQ A;  1TMO A;  5FTL A;  5FTM A;  5EQJ B;  3IR6 A;  2QQR A;  2Q1C X;  5EPP A;  5T5I D;  2DMR A;  5DYI A;  2JA6 A;  4KDL A;  1AA6 A;  2O5J D;  4CRZ A;  1PT1 A;  1SMY D;  1I50 A;  1E18 A;  1G8J A;  4FIB A;  3ZJU A;  2GAE A;  1Y1V A;  1WLF A;  5B6C A;  1SFO A;  1KQG A;  1OGY A;  2E7Z A;  2WB1 A;  5C18 A;  5FTJ A;  1G8K A;  2A6H D;  2GFA A;  1EU1 A;  2VPZ A;  3OUG A;  1CZ4 A;  4RV0 A;  1PPY A;  3GTM A;  1QDN A;  1PT0 A;  2E2I A;  2JIM A;  2Q1A X;  1TWF A;  2VUM A;  5FTN A;  4GA6 A;  5C1B A;  1CZ5 A;  2A6E D;  1I3Q A;  3QC8 A;  2VPX A;  2MM2 A;  1E5V A;  5T5M D;  3TIW A;  4AOK B;  1PQF A;  2AE0 X;  4AZD A;  4GA5 A;  4KDI A;  2YUJ A;  4D7Z B;  4CQN A;  2Q18 X;  4AYB A;  3GTO A;  1TWA A;  4KLN A;  2E2H A;  2KY9 A;  2LW6 A;  2NYA A;  2NAP A;  5DYG A;  2R7Z A;  1AW8 B;  2PNW A;  2B25 A;  2PMZ A;  1Y1W A;  2CW0 D;  2V3V A;  5D6Y A;  1H5N A;  3BQB A;  1DMR A;  4KOD A;  2G5D A;  4AAY A;  1TWC A;  5D6X A;  2MM0 A;  1DMS A;  1TWH A;  3FPU A;  2NVY A;  4DMR A;  1KQF A;  2EEO B;  3HU1 A;  5CCB A;  3HKZ A;  1K83 A;  1R9T A;  1UHE A;  1FDO A;  4ARC A;  2PIC A;  1Q16 A;  3ML1 A;  4AQ7 A;  1PYU B;  3FPR A;  3ZGZ A;  1I9G A;  2PJH B;  1SIW A;  1FDI A;  3ZJT A;  1YNN D;  2Q1D X;  5CD1 A;  3FKI A;  4KO8 A;  1PYQ A;  1UHD A;  3GTK A;  2R92 A;  2QQS A;  1VC3 B;  2G6G A;  1R7R A;  1WCM A;  3HU3 A;  3LHD A;  4ARI A;  2A69 D;  4NOH A;  2WAQ A;  5FTK A;  3QWZ A;  1CR5 A;  3TM7 B;  2NVX A;  3GTQ A;  3FPT A;  2YVL A;  2R93 A;  2Y0S A;  3O5A A;  2JA5 A;  1QCS A;  3QQ7 A;  4AON B;  1ZC1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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