1I72B

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound 5'-deoxy-5'-[n-methyl-n-(2-aminooxyethyl) amino]adenosine
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 6
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-07
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i72B01
1I79B 3EPAB 3DZ7B 3EP6B 3DZ6B 1I72B 3EP7B 3H0VB 3DZ3B 3EPBB 1I7MB 3H0WB 3EP3B 1I7CB 3DZ2B 3DZ5B 3EP9B 3EP4B 3EP5B 1I7BB 5TVOB 1JENB 3DZ4B 3EP8B 1MHMB
chains in the Genus database with same CATH superfamily
1H9BA 1NQOA 3Q0EA 3DBVO 3QV1A 5J9GA 2I3GA 3IWBB 1GYPA 3DO5A 1NQ5A 4CLQA 1SZJG 1JKFA 4LSMA 2HO5A 1CERA 2R00A 3HXLA 5KVQA 3CINA 3WGQA 1J0XO 3MTJA 1YDWA 4XQCA 1PS8A 3H9EO 1P1FA 3O9ZA 4MVJM 1IHXA 4YDRA 1H6DA 2OZPA 2GZ2A 3EPAB 3EP7B 3WBBA 1GAEO 1EBFA 1VKOA 1ZNQO 2I3AA 3C1AA 3E6AA 1DC6A 4MKZA 1P1KA 3ZCXA 4R54A 5TVOB 5DDIP 3JSAA 1RM5A 4MVJF 4DIBA 3V1YA 3DB2A 4MKXA 4GPD1 3VOSA 3RCBA 2VYVA 1DIHA 4MIOA 3F4LA 1J5PA 3WGZA 3EP6B 1DC5A 3QY9A 3L0DA 3U3XA 4R4JA 1JKIA 3RC2A 3DZ2B 3IP3A 3KSZO 3EP4B 1DSSG 1RYEA 3QVWA 4WNIA 5JYFA 4LGVA 3DAPA 3GPDG 3WBFA 1E7YA 1LC0A 1VKNA 1DC3A 3INGA 4BOYA 1QKIA 4N54A 3UUWA 5GZ1A 3IWDB 3DOCA 2YV3A 1K3TA 3K2BA 3L6OO 3IDSA 5CEFA 3BTSA 1RM3A 1I7MB 3EPBB 2EJWA 4MJLA 3PFWO 3TUTA 1GADO 5EINA 3PQVA 3EUWA 3EP9B 3EP5B 4ZICA 3GFGA 3MOIA 2BH9A 2BHLA 3PZBA 5A05A 5C7OO 3PYLA 3NTOA 1PU2A 1I72B 4INAA 1NPTO 1NWCA 2D2IA 3TW3A 3WGYA 2B4RO 3CMCO 1EBUA 3HNPA 1E5QA 3LC1O 2DC1A 1H9AA 5EIOA 4O8JA 1C3VA 4XR4A 1DPGA 2G82A 3E5RA 3NT5A 4TVBA 1NX6A 2XF8A 2PKRA 4HKTA 3TUXA 1I79B 3NT2A 1P1IA 1P1JA 3M2TA 3NTRA 2DAPA 2X0NA 1PQUA 1E5LA 4MVJA 4FB5A 2POQX 3Q2KA 1YS4A 5JW6A 4MIEA 2VYND 3OQBA 4HADA 5C7LO 1H94A 3V2UA 1NBOA 5EESA 3RVDA 1A7KA 1TVEA 4JN6B 3E9MA 1OFGA 3PYXA 1I7CB 1H2HA 1DC4A 3WYCA 2G17A 2O4UX 1FF9A 3ZDFA 3GDOA 3K73O 1EVJA 1CRWG 4DPMA 2GZ3A 3BIOA 3ABIA 4XQEA 2FPNA 1PR3A 3BTVA 1T4DA 2IXAA 3NT4A 2I5PO 3CPSA 3WB9A 3H0WB 5BNTA 1ARZA 5M6DA 4PLPA 5A04A 3E1KA 3L4SO 1TA4A 1I7BB 3V5NA 2Q22A 1XYGA 1JN0A 4QX6A 5GZ3A 2NVWA 3TZ6A 5AQ1A 2IXBA 5GZ6A 3PYMA 2R00C 3C8MA 2CVOA 1VSUA 5JYEA 4F3YA 4K9DA 4PG7A 2DBVO 3DMTA 3OHSX 4L9RA 1NVMB 1NQAO 1VSVA 3EC7A 1P9LA 1DBVO 4MINA 3RBVA 3RC9A 1ZH8A 3QVTA 3KGDA 3LC7O 4EW6A 2CZCA 4IQ8A 3MZ0A 4KOAA 1I32A 1TLTA 4ZHSA 1BRMA 3DZ6B 2X5JO 1B7GO 3K9QO 2EP7A 2X5KO 3EP3B 2VYVD 3FHLA 4H3VA 4R5MA 5AVOA 2GYYA 4XQ9A 3WGOA 2YYYA 3KV3O 2GD1O 1NWHA 4P8RA 3QVXA 2Q4EA 1S7CA 1H6AA 1GR0A 1DAPA 1QXSA 2H63A 3Q11A 4DPLA 5A06A 4L8VA 2HJSA 1H6BA 4R51A 3WYBA 1RM4A 3IWCB 4GMGA 1XEAA 4DBVO 4MVJG 3PWKA 1DRWA 1MC4A 1MB4A 4LRTB 3UW3A 1OZAA 1U1IA 4LRSB 2O48X 3FD8A 5JY6A 3LC2O 4GQAA 1YL6A 4MVJH 4PG5A 4XB2A 1CF2O 1VM6A 3DZ3B 1RM0A 3RC1A 4XB1A 4R5HA 3QVSA 4Z0HO 4R41A 1GCUA 1UYJA 5T73A 3PZRA 1E77A 2HKIA 4NHEA 3DZ4B 2PH5A 2QZ9A 4RL6A 2B4TO 4O63O 3EVNA 1Q7GA 1H93A 1YL5A 1DRVA 1E7MA 4GMFA 3H0VB 4MVJP 1GD1O 3HJAA 4DPKA 2P2SA 3E82A 1GPDG 3DZ5B 1LA2A 4YWJA 2AXQA 3STHA 4O59O 5JYAA 4XRGA 1ML3A 3E18A 4MVJD 3I23A 3DZ7B 4PG4A 1F06A 4PG8A 5A03A 2DUUA 2DPGA 1RYDA 1VC2A 4II7A 3RC7A 3IJPA 1JENB 1YWGO 3DR3A 3HSKA 3NTQA 1Q2XA 1T4BA 2Q49A 3Q1LA 4R3NA 1MHMB 2PKQP 3KUXA 4R3WA 3PWSA 1QMIA 3OA0A 5A02A 1YL7A 4IQ0A 3HQ4O 4AK1A 2PKQO 1HDGO 4XQGA 3CEAA 2VYNA 4O89A 3OA2A 3CIFA 3ZJXA 5KVSA 3EZYA 1H6CA 3QW2A 1GYQA 1OBFO 2GZ1A 1PQPA 2NQTA 1U8FO 3B1KA 3DTYA 4PG6A 3TV1A 4WNCA 3B1JA 1P1HA 4MVJE 3BTUA 3B20A 5EERA 3Q2IA 2EP5A 3LVFO 4MVJI 1GL3A 1DRUA 3KSDO 5C7IO 1IHYA 3DMTC 1I33A 1QMHA 4WOJA 4MIYA 3VAZA 1TB4A 2GLXA 3EP8B 1LC3A 3GNQA
chains in the Genus database with same CATH topology
1I7CA 1I79B 3DZ2A 3EPAB 3DZ5A 3DZ7B 3EP6B 3DZ6B 3EP9A 1I72B 3EP7B 3EP4A 3H0VB 3EP5A 3DZ3B 1I7BA 3EPBB 1I7MB 3H0WB 1TLUA 5TVOA 1JENA 3EP3B 3DZ4A 1JL0A 1I7CB 3DZ2B 3DZ5B 3EP9B 3EP8A 1MSVA 3EP4B 3EP5B 1I7BB 1VR7A 5TVOB 1JENB 3DZ4B 1I79A 1MHMA 3EPAA 3EP8B 3EP7A 3DZ7A 3EP6A 3DZ6A 3H0VA 1I72A 3EPBA 1I7MA 3H0WA 3DZ3A 1TMIA 1MHMB 3EP3A 2IIIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I79 B;  3EPA B;  3DZ7 B;  3EP6 B;  3DZ6 B;  1I72 B;  3EP7 B;  3H0V B;  3DZ3 B;  3EPB B;  1I7M B;  3H0W B;  3EP3 B;  1I7C B;  3DZ2 B;  3DZ5 B;  3EP9 B;  3EP4 B;  3EP5 B;  1I7B B;  5TVO B;  1JEN B;  3DZ4 B;  3EP8 B;  1MHM B; 
#chains in the Genus database with same CATH topology
 1H9B A;  1NQO A;  3Q0E A;  3DBV O;  3QV1 A;  5J9G A;  2I3G A;  3IWB B;  1GYP A;  3DO5 A;  1NQ5 A;  4CLQ A;  1SZJ G;  1JKF A;  4LSM A;  2HO5 A;  1CER A;  2R00 A;  3HXL A;  5KVQ A;  3CIN A;  3WGQ A;  1J0X O;  3MTJ A;  1YDW A;  4XQC A;  1PS8 A;  3H9E O;  1P1F A;  3O9Z A;  4MVJ M;  1IHX A;  4YDR A;  1H6D A;  2OZP A;  2GZ2 A;  3EPA B;  3EP7 B;  3WBB A;  1GAE O;  1EBF A;  1VKO A;  1ZNQ O;  2I3A A;  3C1A A;  3E6A A;  1DC6 A;  4MKZ A;  1P1K A;  3ZCX A;  4R54 A;  5TVO B;  5DDI P;  3JSA A;  1RM5 A;  4MVJ F;  4DIB A;  3V1Y A;  3DB2 A;  4MKX A;  4GPD 1;  3VOS A;  3RCB A;  2VYV A;  1DIH A;  4MIO A;  3F4L A;  1J5P A;  3WGZ A;  3EP6 B;  1DC5 A;  3QY9 A;  3L0D A;  3U3X A;  4R4J A;  1JKI A;  3RC2 A;  3DZ2 B;  3IP3 A;  3KSZ O;  3EP4 B;  1DSS G;  1RYE A;  3QVW A;  4WNI A;  5JYF A;  4LGV A;  3DAP A;  3GPD G;  3WBF A;  1E7Y A;  1LC0 A;  1VKN A;  1DC3 A;  3ING A;  4BOY A;  1QKI A;  4N54 A;  3UUW A;  5GZ1 A;  3IWD B;  3DOC A;  2YV3 A;  1K3T A;  3K2B A;  3L6O O;  3IDS A;  5CEF A;  3BTS A;  1RM3 A;  1I7M B;  3EPB B;  2EJW A;  4MJL A;  3PFW O;  3TUT A;  1GAD O;  5EIN A;  3PQV A;  3EUW A;  3EP9 B;  3EP5 B;  4ZIC A;  3GFG A;  3MOI A;  2BH9 A;  2BHL A;  3PZB A;  5A05 A;  5C7O O;  3PYL A;  3NTO A;  1PU2 A;  1I72 B;  4INA A;  1NPT O;  1NWC A;  2D2I A;  3TW3 A;  3WGY A;  2B4R O;  3CMC O;  1EBU A;  3HNP A;  1E5Q A;  3LC1 O;  2DC1 A;  1H9A A;  5EIO A;  4O8J A;  1C3V A;  4XR4 A;  1DPG A;  2G82 A;  3E5R A;  3NT5 A;  4TVB A;  1NX6 A;  2XF8 A;  2PKR A;  4HKT A;  3TUX A;  1I79 B;  3NT2 A;  1P1I A;  1P1J A;  3M2T A;  3NTR A;  2DAP A;  2X0N A;  1PQU A;  1E5L A;  4MVJ A;  4FB5 A;  2POQ X;  3Q2K A;  1YS4 A;  5JW6 A;  4MIE A;  2VYN D;  3OQB A;  4HAD A;  5C7L O;  1H94 A;  3V2U A;  1NBO A;  5EES A;  3RVD A;  1A7K A;  1TVE A;  4JN6 B;  3E9M A;  1OFG A;  3PYX A;  1I7C B;  1H2H A;  1DC4 A;  3WYC A;  2G17 A;  2O4U X;  1FF9 A;  3ZDF A;  3GDO A;  3K73 O;  1EVJ A;  1CRW G;  4DPM A;  2GZ3 A;  3BIO A;  3ABI A;  4XQE A;  2FPN A;  1PR3 A;  3BTV A;  1T4D A;  2IXA A;  3NT4 A;  2I5P O;  3CPS A;  3WB9 A;  3H0W B;  5BNT A;  1ARZ A;  5M6D A;  4PLP A;  5A04 A;  3E1K A;  3L4S O;  1TA4 A;  1I7B B;  3V5N A;  2Q22 A;  1XYG A;  1JN0 A;  4QX6 A;  5GZ3 A;  2NVW A;  3TZ6 A;  5AQ1 A;  2IXB A;  5GZ6 A;  3PYM A;  2R00 C;  3C8M A;  2CVO A;  1VSU A;  5JYE A;  4F3Y A;  4K9D A;  4PG7 A;  2DBV O;  3DMT A;  3OHS X;  4L9R A;  1NVM B;  1NQA O;  1VSV A;  3EC7 A;  1P9L A;  1DBV O;  4MIN A;  3RBV A;  3RC9 A;  1ZH8 A;  3QVT A;  3KGD A;  3LC7 O;  4EW6 A;  2CZC A;  4IQ8 A;  3MZ0 A;  4KOA A;  1I32 A;  1TLT A;  4ZHS A;  1BRM A;  3DZ6 B;  2X5J O;  1B7G O;  3K9Q O;  2EP7 A;  2X5K O;  3EP3 B;  2VYV D;  3FHL A;  4H3V A;  4R5M A;  5AVO A;  2GYY A;  4XQ9 A;  3WGO A;  2YYY A;  3KV3 O;  2GD1 O;  1NWH A;  4P8R A;  3QVX A;  2Q4E A;  1S7C A;  1H6A A;  1GR0 A;  1DAP A;  1QXS A;  2H63 A;  3Q11 A;  4DPL A;  5A06 A;  4L8V A;  2HJS A;  1H6B A;  4R51 A;  3WYB A;  1RM4 A;  3IWC B;  4GMG A;  1XEA A;  4DBV O;  4MVJ G;  3PWK A;  1DRW A;  1MC4 A;  1MB4 A;  4LRT B;  3UW3 A;  1OZA A;  1U1I A;  4LRS B;  2O48 X;  3FD8 A;  5JY6 A;  3LC2 O;  4GQA A;  1YL6 A;  4MVJ H;  4PG5 A;  4XB2 A;  1CF2 O;  1VM6 A;  3DZ3 B;  1RM0 A;  3RC1 A;  4XB1 A;  4R5H A;  3QVS A;  4Z0H O;  4R41 A;  1GCU A;  1UYJ A;  5T73 A;  3PZR A;  1E77 A;  2HKI A;  4NHE A;  3DZ4 B;  2PH5 A;  2QZ9 A;  4RL6 A;  2B4T O;  4O63 O;  3EVN A;  1Q7G A;  1H93 A;  1YL5 A;  1DRV A;  1E7M A;  4GMF A;  3H0V B;  4MVJ P;  1GD1 O;  3HJA A;  4DPK A;  2P2S A;  3E82 A;  1GPD G;  3DZ5 B;  1LA2 A;  4YWJ A;  2AXQ A;  3STH A;  4O59 O;  5JYA A;  4XRG A;  1ML3 A;  3E18 A;  4MVJ D;  3I23 A;  3DZ7 B;  4PG4 A;  1F06 A;  4PG8 A;  5A03 A;  2DUU A;  2DPG A;  1RYD A;  1VC2 A;  4II7 A;  3RC7 A;  3IJP A;  1JEN B;  1YWG O;  3DR3 A;  3HSK A;  3NTQ A;  1Q2X A;  1T4B A;  2Q49 A;  3Q1L A;  4R3N A;  1MHM B;  2PKQ P;  3KUX A;  4R3W A;  3PWS A;  1QMI A;  3OA0 A;  5A02 A;  1YL7 A;  4IQ0 A;  3HQ4 O;  4AK1 A;  2PKQ O;  1HDG O;  4XQG A;  3CEA A;  2VYN A;  4O89 A;  3OA2 A;  3CIF A;  3ZJX A;  5KVS A;  3EZY A;  1H6C A;  3QW2 A;  1GYQ A;  1OBF O;  2GZ1 A;  1PQP A;  2NQT A;  1U8F O;  3B1K A;  3DTY A;  4PG6 A;  3TV1 A;  4WNC A;  3B1J A;  1P1H A;  4MVJ E;  3BTU A;  3B20 A;  5EER A;  3Q2I A;  2EP5 A;  3LVF O;  4MVJ I;  1GL3 A;  1DRU A;  3KSD O;  5C7I O;  1IHY A;  3DMT C;  1I33 A;  1QMH A;  4WOJ A;  4MIY A;  3VAZ A;  1TB4 A;  2GLX A;  3EP8 B;  1LC3 A;  3GNQ A; 
#chains in the Genus database with same CATH homology
 1I7C A;  1I79 B;  3DZ2 A;  3EPA B;  3DZ5 A;  3DZ7 B;  3EP6 B;  3DZ6 B;  3EP9 A;  1I72 B;  3EP7 B;  3EP4 A;  3H0V B;  3EP5 A;  3DZ3 B;  1I7B A;  3EPB B;  1I7M B;  3H0W B;  1TLU A;  5TVO A;  1JEN A;  3EP3 B;  3DZ4 A;  1JL0 A;  1I7C B;  3DZ2 B;  3DZ5 B;  3EP9 B;  3EP8 A;  1MSV A;  3EP4 B;  3EP5 B;  1I7B B;  1VR7 A;  5TVO B;  1JEN B;  3DZ4 B;  1I79 A;  1MHM A;  3EPA A;  3EP8 B;  3EP7 A;  3DZ7 A;  3EP6 A;  3DZ6 A;  3H0V A;  1I72 A;  3EPB A;  1I7M A;  3H0W A;  3DZ3 A;  1TMI A;  1MHM B;  3EP3 A;  2III A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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