1I7BB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound s-adenosylmethionine methyl ester
Total Genus 6
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
6
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 6
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7bB01
3DZ7B 3H0VB 3DZ5B 3DZ2B 3EP7B 3EPBB 3EPAB 1MHMB 3DZ6B 1I7MB 3EP8B 1I72B 5TVOB 1I7BB 3DZ4B 3EP3B 1I79B 1I7CB 3EP5B 3EP4B 3EP9B 1JENB 3DZ3B 3H0WB 3EP6B
chains in the Genus database with same CATH superfamily
2B4TO 1C3VA 2DPGA 2DAPA 3DZ2B 3O9ZA 3GFGA 3HQ4O 4O63O 1MHMB 4MIEA 3HSKA 1P1JA 4GPD1 1P1HA 4GMGA 3E1KA 4F3YA 1E5LA 5KVQA 3IJPA 5JYFA 4PG4A 1H2HA 4YWJA 1J0XO 3QW2A 1NWCA 1GADO 1H94A 1ZH8A 3EPAB 3UW3A 4HKTA 1CF2O 3PYXA 1DRWA 3EP4B 4DPLA 3CINA 1JENB 1GR0A 2PH5A 4R5MA 4MVJI 3U3XA 3QVWA 2X5JO 2XF8A 3WGZA 5T73A 1H9AA 5AVOA 1RYEA 2EP7A 3OA2A 1NQOA 1YL6A 4L8VA 1EBUA 3TUTA 3WB9A 1U8FO 2I3AA 3Q2KA 5GZ6A 1YS4A 2CZCA 1NVMB 1P1KA 1DRVA 1PQPA 2O48X 4LRTB 1GYPA 3DMTC 2DBVO 3DZ7B 2HO5A 4AK1A 4YDRA 1P9LA 2VYNA 3DOCA 4MVJA 3DZ5B 1PQUA 3PQVA 1DC5A 5CEFA 3RC9A 2PKQO 1CERA 1P1FA 3HJAA 4XQCA 1LA2A 1HDGO 3CIFA 3EP9B 3I23A 2PKRA 3RC1A 2IXAA 1NPTO 2D2IA 1SZJG 4O59O 2Q49A 3C1AA 3Q11A 3OA0A 3WBBA 1VM6A 3MOIA 1JKFA 2EJWA 2EP5A 1GCUA 5DDIP 4LRSB 1I7MB 1QXSA 5TVOB 5M6DA 3QY9A 4N54A 5JYEA 4WNCA 1E77A 3E82A 4MVJD 3C8MA 1TLTA 3OQBA 3K9QO 3KSDO 3K73O 4O8JA 1I32A 1UYJA 4ZICA 4PG6A 2QZ9A 3B1JA 4LSMA 5JY6A 3FHLA 4HADA 4R4JA 1VSVA 1TVEA 3EPBB 4ZHSA 1XYGA 3DZ6B 1RM5A 4IQ8A 2POQX 3KV3O 1NQ5A 1E7YA 1PR3A 3ZDFA 3BTUA 3NTRA 1I33A 3VAZA 3PFWO 1A7KA 1DC6A 2AXQA 5A05A 1RM0A 3NTQA 3K2BA 4DPKA 5C7LO 1H6CA 3BTVA 3VOSA 3EP8B 1S7CA 1I7BB 1H93A 5A04A 1LC0A 2GYYA 3DMTA 2GD1O 3L0DA 4MVJE 3NT2A 3DB2A 3TV1A 3B1KA 1RM3A 1YWGO 2NVWA 3WGOA 3WYCA 3Q0EA 4P8RA 1H6DA 4K9DA 1ZNQO 3EVNA 4WOJA 3MZ0A 2OZPA 4R5HA 2FPNA 5GZ3A 1ARZA 4IQ0A 5EERA 1E5QA 1NQAO 3L6OO 3H9EO 4KOAA 3H0WB 3EZYA 1J5PA 3KSZO 5JW6A 1VKNA 5JYAA 3Q2IA 3EUWA 4MVJH 4XQGA 3TZ6A 3MTJA 3E6AA 4DPMA 5C7IO 4R3NA 1I79B 4MINA 4INAA 4MVJP 3ZJXA 4DIBA 1DRUA 3OHSX 3TW3A 3EC7A 3PZRA 3IWDB 3LC7O 5BNTA 4CLQA 3GNQA 3WYBA 4Z0HO 2I5PO 2G17A 1QKIA 4XR4A 1MC4A 3DAPA 3RCBA 1FF9A 3V2UA 3GDOA 1TA4A 3UUWA 2O4UX 4MVJG 4FB5A 3PWSA 4LGVA 1GYQA 1GD1O 3NT5A 3HNPA 3RC2A 1OFGA 2YV3A 3DO5A 3PZBA 5EIOA 2I3GA 1YL7A 1DC4A 4R3WA 1EVJA 4R51A 1I72B 1U1IA 2BH9A 2VYVA 3KUXA 4NHEA 1P1IA 4XB2A 3IP3A 1IHYA 4MIOA 1NX6A 2GZ1A 3JSAA 3LVFO 4BOYA 4MKZA 4O89A 5KVSA 2PKQP 1OZAA 2R00C 5A03A 2G82A 3HXLA 1H6BA 3E18A 2YYYA 1DPGA 1BRMA 3WGQA 5GZ1A 1EBFA 3NT4A 1RM4A 3TUXA 4GQAA 5C7OO 3BTSA 4H3VA 3ZCXA 1Q7GA 3RC7A 4DBVO 3KGDA 5J9GA 2P2SA 2VYVD 1GPDG 2DUUA 3WBFA 3LC1O 1JKIA 2IXBA 3EP7B 1VSUA 3PWKA 1NWHA 4PG8A 3ABIA 3WGYA 1CRWG 1H6AA 3DBVO 2GZ2A 3QVTA 3EP3B 1LC3A 3Q1LA 1K3TA 1MB4A 4PLPA 3M2TA 4R41A 1YL5A 1QMIA 2HJSA 3QV1A 1NBOA 3V1YA 3EP6B 1OBFO 2X0NA 3CEAA 3IDSA 3PYMA 2GZ3A 3DTYA 3RBVA 2GLXA 3CMCO 4TVBA 2HKIA 1VKOA 3RVDA 2Q4EA 2NQTA 3IWBB 4MJLA 2B4RO 4MKXA 4QX6A 3PYLA 3L4SO 3EP5B 1DAPA 1IHXA 5A02A 4MVJM 5A06A 4L9RA 1DBVO 4JN6B 1T4BA 3NTOA 1E7MA 4R54A 4WNIA 3F4LA 1B7GO 3QVSA 1YDWA 4MIYA 4EW6A 1PU2A 3DR3A 3IWCB 1XEAA 1DIHA 4II7A 4XQEA 3INGA 3FD8A 1ML3A 1DC3A 4RL6A 4XB1A 3B20A 2CVOA 3E9MA 2H63A 3DZ3B 1DSSG 1PS8A 4PG5A 1TB4A 3H0VB 5EESA 3CPSA 1JN0A 2R00A 4XRGA 3LC2O 5AQ1A 2X5KO 3V5NA 3GPDG 4MVJF 4GMFA 2BHLA 4PG7A 2Q22A 5EINA 3DZ4B 1RYDA 3STHA 1I7CB 1GL3A 1H9BA 2VYND 1Q2XA 1GAEO 1F06A 3QVXA 4XQ9A 1VC2A 1QMHA 1T4DA 2DC1A 3BIOA 3E5RA
chains in the Genus database with same CATH topology
1JL0A 1I7MA 1VR7A 3DZ7B 1I72A 3EP8A 3H0VB 5TVOA 1I7BA 3DZ4A 3EP3A 3EP5A 1I79A 1I7CA 3EP4A 3EP9A 3DZ5B 3DZ2B 1MSVA 3EP7B 3EPBB 1JENA 3EPAB 3EP6B 1MHMB 3DZ6B 1I7MB 3EP8B 1I72B 5TVOB 3DZ3A 1I7BB 3DZ4B 3EP3B 1I79B 1I7CB 3DZ7A 3EP5B 3EP6A 3EP9B 3EP4B 3H0WA 3H0VA 1TLUA 1JENB 3DZ6A 1TMIA 2IIIA 3DZ5A 3DZ2A 3EP7A 3EPBA 3DZ3B 3EPAA 3H0WB 1MHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ7 B;  3H0V B;  3DZ5 B;  3DZ2 B;  3EP7 B;  3EPB B;  3EPA B;  1MHM B;  3DZ6 B;  1I7M B;  3EP8 B;  1I72 B;  5TVO B;  1I7B B;  3DZ4 B;  3EP3 B;  1I79 B;  1I7C B;  3EP5 B;  3EP4 B;  3EP9 B;  1JEN B;  3DZ3 B;  3H0W B;  3EP6 B; 
#chains in the Genus database with same CATH topology
 2B4T O;  1C3V A;  2DPG A;  2DAP A;  3DZ2 B;  3O9Z A;  3GFG A;  3HQ4 O;  4O63 O;  1MHM B;  4MIE A;  3HSK A;  1P1J A;  4GPD 1;  1P1H A;  4GMG A;  3E1K A;  4F3Y A;  1E5L A;  5KVQ A;  3IJP A;  5JYF A;  4PG4 A;  1H2H A;  4YWJ A;  1J0X O;  3QW2 A;  1NWC A;  1GAD O;  1H94 A;  1ZH8 A;  3EPA B;  3UW3 A;  4HKT A;  1CF2 O;  3PYX A;  1DRW A;  3EP4 B;  4DPL A;  3CIN A;  1JEN B;  1GR0 A;  2PH5 A;  4R5M A;  4MVJ I;  3U3X A;  3QVW A;  2X5J O;  2XF8 A;  3WGZ A;  5T73 A;  1H9A A;  5AVO A;  1RYE A;  2EP7 A;  3OA2 A;  1NQO A;  1YL6 A;  4L8V A;  1EBU A;  3TUT A;  3WB9 A;  1U8F O;  2I3A A;  3Q2K A;  5GZ6 A;  1YS4 A;  2CZC A;  1NVM B;  1P1K A;  1DRV A;  1PQP A;  2O48 X;  4LRT B;  1GYP A;  3DMT C;  2DBV O;  3DZ7 B;  2HO5 A;  4AK1 A;  4YDR A;  1P9L A;  2VYN A;  3DOC A;  4MVJ A;  3DZ5 B;  1PQU A;  3PQV A;  1DC5 A;  5CEF A;  3RC9 A;  2PKQ O;  1CER A;  1P1F A;  3HJA A;  4XQC A;  1LA2 A;  1HDG O;  3CIF A;  3EP9 B;  3I23 A;  2PKR A;  3RC1 A;  2IXA A;  1NPT O;  2D2I A;  1SZJ G;  4O59 O;  2Q49 A;  3C1A A;  3Q11 A;  3OA0 A;  3WBB A;  1VM6 A;  3MOI A;  1JKF A;  2EJW A;  2EP5 A;  1GCU A;  5DDI P;  4LRS B;  1I7M B;  1QXS A;  5TVO B;  5M6D A;  3QY9 A;  4N54 A;  5JYE A;  4WNC A;  1E77 A;  3E82 A;  4MVJ D;  3C8M A;  1TLT A;  3OQB A;  3K9Q O;  3KSD O;  3K73 O;  4O8J A;  1I32 A;  1UYJ A;  4ZIC A;  4PG6 A;  2QZ9 A;  3B1J A;  4LSM A;  5JY6 A;  3FHL A;  4HAD A;  4R4J A;  1VSV A;  1TVE A;  3EPB B;  4ZHS A;  1XYG A;  3DZ6 B;  1RM5 A;  4IQ8 A;  2POQ X;  3KV3 O;  1NQ5 A;  1E7Y A;  1PR3 A;  3ZDF A;  3BTU A;  3NTR A;  1I33 A;  3VAZ A;  3PFW O;  1A7K A;  1DC6 A;  2AXQ A;  5A05 A;  1RM0 A;  3NTQ A;  3K2B A;  4DPK A;  5C7L O;  1H6C A;  3BTV A;  3VOS A;  3EP8 B;  1S7C A;  1I7B B;  1H93 A;  5A04 A;  1LC0 A;  2GYY A;  3DMT A;  2GD1 O;  3L0D A;  4MVJ E;  3NT2 A;  3DB2 A;  3TV1 A;  3B1K A;  1RM3 A;  1YWG O;  2NVW A;  3WGO A;  3WYC A;  3Q0E A;  4P8R A;  1H6D A;  4K9D A;  1ZNQ O;  3EVN A;  4WOJ A;  3MZ0 A;  2OZP A;  4R5H A;  2FPN A;  5GZ3 A;  1ARZ A;  4IQ0 A;  5EER A;  1E5Q A;  1NQA O;  3L6O O;  3H9E O;  4KOA A;  3H0W B;  3EZY A;  1J5P A;  3KSZ O;  5JW6 A;  1VKN A;  5JYA A;  3Q2I A;  3EUW A;  4MVJ H;  4XQG A;  3TZ6 A;  3MTJ A;  3E6A A;  4DPM A;  5C7I O;  4R3N A;  1I79 B;  4MIN A;  4INA A;  4MVJ P;  3ZJX A;  4DIB A;  1DRU A;  3OHS X;  3TW3 A;  3EC7 A;  3PZR A;  3IWD B;  3LC7 O;  5BNT A;  4CLQ A;  3GNQ A;  3WYB A;  4Z0H O;  2I5P O;  2G17 A;  1QKI A;  4XR4 A;  1MC4 A;  3DAP A;  3RCB A;  1FF9 A;  3V2U A;  3GDO A;  1TA4 A;  3UUW A;  2O4U X;  4MVJ G;  4FB5 A;  3PWS A;  4LGV A;  1GYQ A;  1GD1 O;  3NT5 A;  3HNP A;  3RC2 A;  1OFG A;  2YV3 A;  3DO5 A;  3PZB A;  5EIO A;  2I3G A;  1YL7 A;  1DC4 A;  4R3W A;  1EVJ A;  4R51 A;  1I72 B;  1U1I A;  2BH9 A;  2VYV A;  3KUX A;  4NHE A;  1P1I A;  4XB2 A;  3IP3 A;  1IHY A;  4MIO A;  1NX6 A;  2GZ1 A;  3JSA A;  3LVF O;  4BOY A;  4MKZ A;  4O89 A;  5KVS A;  2PKQ P;  1OZA A;  2R00 C;  5A03 A;  2G82 A;  3HXL A;  1H6B A;  3E18 A;  2YYY A;  1DPG A;  1BRM A;  3WGQ A;  5GZ1 A;  1EBF A;  3NT4 A;  1RM4 A;  3TUX A;  4GQA A;  5C7O O;  3BTS A;  4H3V A;  3ZCX A;  1Q7G A;  3RC7 A;  4DBV O;  3KGD A;  5J9G A;  2P2S A;  2VYV D;  1GPD G;  2DUU A;  3WBF A;  3LC1 O;  1JKI A;  2IXB A;  3EP7 B;  1VSU A;  3PWK A;  1NWH A;  4PG8 A;  3ABI A;  3WGY A;  1CRW G;  1H6A A;  3DBV O;  2GZ2 A;  3QVT A;  3EP3 B;  1LC3 A;  3Q1L A;  1K3T A;  1MB4 A;  4PLP A;  3M2T A;  4R41 A;  1YL5 A;  1QMI A;  2HJS A;  3QV1 A;  1NBO A;  3V1Y A;  3EP6 B;  1OBF O;  2X0N A;  3CEA A;  3IDS A;  3PYM A;  2GZ3 A;  3DTY A;  3RBV A;  2GLX A;  3CMC O;  4TVB A;  2HKI A;  1VKO A;  3RVD A;  2Q4E A;  2NQT A;  3IWB B;  4MJL A;  2B4R O;  4MKX A;  4QX6 A;  3PYL A;  3L4S O;  3EP5 B;  1DAP A;  1IHX A;  5A02 A;  4MVJ M;  5A06 A;  4L9R A;  1DBV O;  4JN6 B;  1T4B A;  3NTO A;  1E7M A;  4R54 A;  4WNI A;  3F4L A;  1B7G O;  3QVS A;  1YDW A;  4MIY A;  4EW6 A;  1PU2 A;  3DR3 A;  3IWC B;  1XEA A;  1DIH A;  4II7 A;  4XQE A;  3ING A;  3FD8 A;  1ML3 A;  1DC3 A;  4RL6 A;  4XB1 A;  3B20 A;  2CVO A;  3E9M A;  2H63 A;  3DZ3 B;  1DSS G;  1PS8 A;  4PG5 A;  1TB4 A;  3H0V B;  5EES A;  3CPS A;  1JN0 A;  2R00 A;  4XRG A;  3LC2 O;  5AQ1 A;  2X5K O;  3V5N A;  3GPD G;  4MVJ F;  4GMF A;  2BHL A;  4PG7 A;  2Q22 A;  5EIN A;  3DZ4 B;  1RYD A;  3STH A;  1I7C B;  1GL3 A;  1H9B A;  2VYN D;  1Q2X A;  1GAE O;  1F06 A;  3QVX A;  4XQ9 A;  1VC2 A;  1QMH A;  1T4D A;  2DC1 A;  3BIO A;  3E5R A; 
#chains in the Genus database with same CATH homology
 1JL0 A;  1I7M A;  1VR7 A;  3DZ7 B;  1I72 A;  3EP8 A;  3H0V B;  5TVO A;  1I7B A;  3DZ4 A;  3EP3 A;  3EP5 A;  1I79 A;  1I7C A;  3EP4 A;  3EP9 A;  3DZ5 B;  3DZ2 B;  1MSV A;  3EP7 B;  3EPB B;  1JEN A;  3EPA B;  3EP6 B;  1MHM B;  3DZ6 B;  1I7M B;  3EP8 B;  1I72 B;  5TVO B;  3DZ3 A;  1I7B B;  3DZ4 B;  3EP3 B;  1I79 B;  1I7C B;  3DZ7 A;  3EP5 B;  3EP6 A;  3EP9 B;  3EP4 B;  3H0W A;  3H0V A;  1TLU A;  1JEN B;  3DZ6 A;  1TMI A;  2III A;  3DZ5 A;  3DZ2 A;  3EP7 A;  3EPB A;  3DZ3 B;  3EPA A;  3H0W B;  1MHM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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