1I7CB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with methylglyoxal bis-(guanylhydrazone)
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 9
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7cB01
1I7CB 1MHMB 3DZ2B 3DZ6B 3DZ5B 3DZ7B 3EPBB 1I72B 1I7MB 3EP4B 1I79B 3EP6B 3EP3B 3DZ4B 3EP9B 1JENB 3EP5B 1I7BB 3H0VB 3EP7B 3DZ3B 5TVOB 3EPAB 3H0WB 3EP8B
chains in the Genus database with same CATH superfamily
1ARZA 4XQ9A 5C7IO 3IP3A 1GCUA 3RCBA 1HDGO 1NPTO 3E6AA 4Z0HO 3IWCB 1I72B 1TLTA 3Q0EA 3QVWA 3O9ZA 3PYXA 3WGQA 2HJSA 3EP5B 3NT4A 1I33A 4MVJH 5A06A 1Q7GA 2QZ9A 1PR3A 1VSVA 3KSDO 1EVJA 4MVJA 3TUTA 3FHLA 3JSAA 1J5PA 3OQBA 4MKXA 1NX6A 1A7KA 3WBBA 3LC7O 3H9EO 3DTYA 3EP4B 1CRWG 1PQPA 1I32A 1TVEA 3NT2A 2I3GA 4MINA 4PG8A 2DPGA 2CZCA 3C1AA 1YL7A 2VYNA 3MTJA 3EZYA 4MKZA 3NTOA 4DBVO 3EPBB 3M2TA 2PKQP 3DR3A 4NHEA 1H2HA 1MB4A 4MVJG 3E82A 3STHA 1I7MB 1YL6A 4L8VA 3I23A 4INAA 1DAPA 5KVQA 2R00C 1T4BA 1H9BA 1YDWA 4R5MA 4YDRA 4MVJE 4MIEA 2DUUA 3KUXA 4O63O 5BNTA 1OZAA 1NQOA 3K73O 4JN6B 2GYYA 3FD8A 4CLQA 3QW2A 4MVJI 4PLPA 3LVFO 4MVJD 2P2SA 1S7CA 1PU2A 3DZ2B 3L6OO 3WGOA 3IWBB 2Q49A 3DMTA 1XYGA 2NQTA 3IDSA 1GR0A 1P1KA 3WYBA 1B7GO 3CMCO 1P1IA 3RC7A 3DZ3B 5TVOB 4XQGA 1DBVO 1DPGA 3TUXA 1H6BA 2VYND 3QY9A 1E7YA 5EIOA 1DC3A 4XB1A 3PFWO 4F3YA 2I3AA 1NBOA 1J0XO 3EC7A 3KGDA 3RBVA 3WYCA 3KV3O 4R41A 4WOJA 3H0VB 1DIHA 4R3NA 3BTSA 3V2UA 3EP7B 1VKNA 3PZBA 2H63A 2G82A 2GZ2A 3UUWA 5AQ1A 1NWHA 3TV1A 3PQVA 4N54A 1NQ5A 3DO5A 3MOIA 1DRUA 4PG4A 3ZCXA 1MHMB 3DZ7B 4PG6A 2OZPA 2NVWA 5T73A 3EP9B 2VYVA 3PWSA 1H93A 1LC0A 4DIBA 1P9LA 3QV1A 1ZNQO 4PG5A 3WGYA 4O59O 3K2BA 2PH5A 1LC3A 2O4UX 1RM4A 3WB9A 3RC9A 4GMGA 3PZRA 4XB2A 4DPLA 1I79B 2DAPA 1H6DA 2YYYA 1IHYA 5GZ6A 3UW3A 1GD1O 4HADA 3VOSA 4XQCA 3HJAA 1DRVA 2GZ1A 3DZ5B 3QVSA 4IQ8A 2EJWA 4WNCA 1DRWA 4TVBA 2YV3A 1I7BB 3K9QO 4YWJA 1QXSA 2XF8A 5A04A 3E5RA 2VYVD 4MIYA 2IXAA 3BIOA 4ZHSA 4MJLA 1VC2A 1VKOA 3ZJXA 4XR4A 1EBUA 4P8RA 3WGZA 3MZ0A 1XEAA 1VSUA 3LC2O 4RL6A 5EERA 1DSSG 3L4SO 4KOAA 2BH9A 1CF2O 3Q11A 5A03A 4R5HA 2BHLA 3CEAA 3EVNA 1F06A 3RVDA 4MVJM 3DMTC 1E5QA 3GFGA 1UYJA 1JN0A 3E1KA 3ZDFA 1SZJG 1YWGO 1P1FA 4GMFA 4XQEA 3LC1O 5C7OO 2PKRA 1I7CB 3E18A 4BOYA 4XRGA 1QMIA 4ZICA 5KVSA 3EP6B 1ZH8A 4FB5A 5JW6A 3DOCA 3OA2A 5GZ3A 2EP5A 2I5PO 5AVOA 1OFGA 1CERA 5C7LO 1QMHA 1RM0A 2Q22A 1T4DA 4GPD1 3GPDG 3GNQA 4LSMA 1H6CA 4QX6A 1LA2A 1JKIA 3E9MA 5J9GA 3QVXA 5A02A 4R54A 1PS8A 2DC1A 2DBVO 5EESA 5DDIP 3KSZO 3EUWA 4R4JA 1EBFA 4WNIA 1PQUA 3NTQA 1NWCA 1NQAO 2GD1O 3PYLA 3V1YA 3F4LA 1YL5A 4O89A 4H3VA 1JKFA 3B1KA 5A05A 1TB4A 1H6AA 3DAPA 5GZ1A 3OA0A 1VM6A 1U1IA 1E77A 2HKIA 4MVJP 2O48X 1U8FO 3NTRA 3GDOA 3BTVA 3CINA 3U3XA 1GYQA 3IWDB 4GQAA 2POQX 1GPDG 4LRTB 5M6DA 5CEFA 4R51A 1BRMA 3EP3B 4AK1A 3V5NA 1RM5A 3NT5A 2X5KO 4LGVA 3C8MA 1FF9A 3BTUA 1YS4A 3EPAB 3VAZA 3EP8B 3CIFA 1OBFO 2GLXA 2AXQA 2CVOA 5JYEA 1H9AA 1E5LA 2HO5A 4PG7A 3CPSA 1C3VA 1K3TA 3TZ6A 2EP7A 2R00A 4EW6A 4IQ0A 3DB2A 4DPKA 4II7A 1RM3A 2FPNA 1RYEA 2Q4EA 1MC4A 4K9DA 3HQ4O 4R3WA 1IHXA 2GZ3A 5JYAA 3H0WB 3WBFA 3HNPA 3HXLA 3Q2IA 3Q2KA 2IXBA 3Q1LA 4LRSB 5JY6A 3TW3A 1Q2XA 1E7MA 3INGA 2X0NA 3B20A 4L9RA 3DZ4B 3OHSX 1JENB 3L0DA 2D2IA 1DC5A 1H94A 4MIOA 2X5JO 3IJPA 3DBVO 1QKIA 3RC2A 2PKQO 1GYPA 1NVMB 3HSKA 3PYMA 3DZ6B 1DC4A 2G17A 4DPMA 5JYFA 4O8JA 1GL3A 5EINA 1RYDA 1ML3A 1GAEO 1P1JA 3RC1A 4HKTA 1TA4A 2B4RO 3QVTA 4MVJF 2B4TO 1P1HA 3ABIA 1DC6A 3B1JA 1GADO 3PWKA
chains in the Genus database with same CATH topology
3EP8A 1MSVA 1I7CB 1I7CA 1MHMB 1MHMA 3DZ2B 3DZ5B 3DZ6B 3DZ7B 3DZ6A 3EPBB 3DZ2A 3EPBA 3DZ5A 3DZ7A 1VR7A 1I72B 1I7MB 1I72A 1I7MA 3EP4B 1I79B 3EP6B 3EP4A 3EP3B 1I79A 3DZ4B 3EP6A 3EP9B 3EP3A 1JENB 3DZ4A 3EP5B 1JL0A 3EP5A 3EP9A 1JENA 3H0WB 1I7BA 1I7BB 3H0VB 1TMIA 3H0VA 1TLUA 3EP7B 3EP7A 3DZ3B 5TVOB 2IIIA 3EPAB 3DZ3A 5TVOA 3EPAA 3EP8B 3H0WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I7C B;  1MHM B;  3DZ2 B;  3DZ6 B;  3DZ5 B;  3DZ7 B;  3EPB B;  1I72 B;  1I7M B;  3EP4 B;  1I79 B;  3EP6 B;  3EP3 B;  3DZ4 B;  3EP9 B;  1JEN B;  3EP5 B;  1I7B B;  3H0V B;  3EP7 B;  3DZ3 B;  5TVO B;  3EPA B;  3H0W B;  3EP8 B; 
#chains in the Genus database with same CATH topology
 1ARZ A;  4XQ9 A;  5C7I O;  3IP3 A;  1GCU A;  3RCB A;  1HDG O;  1NPT O;  3E6A A;  4Z0H O;  3IWC B;  1I72 B;  1TLT A;  3Q0E A;  3QVW A;  3O9Z A;  3PYX A;  3WGQ A;  2HJS A;  3EP5 B;  3NT4 A;  1I33 A;  4MVJ H;  5A06 A;  1Q7G A;  2QZ9 A;  1PR3 A;  1VSV A;  3KSD O;  1EVJ A;  4MVJ A;  3TUT A;  3FHL A;  3JSA A;  1J5P A;  3OQB A;  4MKX A;  1NX6 A;  1A7K A;  3WBB A;  3LC7 O;  3H9E O;  3DTY A;  3EP4 B;  1CRW G;  1PQP A;  1I32 A;  1TVE A;  3NT2 A;  2I3G A;  4MIN A;  4PG8 A;  2DPG A;  2CZC A;  3C1A A;  1YL7 A;  2VYN A;  3MTJ A;  3EZY A;  4MKZ A;  3NTO A;  4DBV O;  3EPB B;  3M2T A;  2PKQ P;  3DR3 A;  4NHE A;  1H2H A;  1MB4 A;  4MVJ G;  3E82 A;  3STH A;  1I7M B;  1YL6 A;  4L8V A;  3I23 A;  4INA A;  1DAP A;  5KVQ A;  2R00 C;  1T4B A;  1H9B A;  1YDW A;  4R5M A;  4YDR A;  4MVJ E;  4MIE A;  2DUU A;  3KUX A;  4O63 O;  5BNT A;  1OZA A;  1NQO A;  3K73 O;  4JN6 B;  2GYY A;  3FD8 A;  4CLQ A;  3QW2 A;  4MVJ I;  4PLP A;  3LVF O;  4MVJ D;  2P2S A;  1S7C A;  1PU2 A;  3DZ2 B;  3L6O O;  3WGO A;  3IWB B;  2Q49 A;  3DMT A;  1XYG A;  2NQT A;  3IDS A;  1GR0 A;  1P1K A;  3WYB A;  1B7G O;  3CMC O;  1P1I A;  3RC7 A;  3DZ3 B;  5TVO B;  4XQG A;  1DBV O;  1DPG A;  3TUX A;  1H6B A;  2VYN D;  3QY9 A;  1E7Y A;  5EIO A;  1DC3 A;  4XB1 A;  3PFW O;  4F3Y A;  2I3A A;  1NBO A;  1J0X O;  3EC7 A;  3KGD A;  3RBV A;  3WYC A;  3KV3 O;  4R41 A;  4WOJ A;  3H0V B;  1DIH A;  4R3N A;  3BTS A;  3V2U A;  3EP7 B;  1VKN A;  3PZB A;  2H63 A;  2G82 A;  2GZ2 A;  3UUW A;  5AQ1 A;  1NWH A;  3TV1 A;  3PQV A;  4N54 A;  1NQ5 A;  3DO5 A;  3MOI A;  1DRU A;  4PG4 A;  3ZCX A;  1MHM B;  3DZ7 B;  4PG6 A;  2OZP A;  2NVW A;  5T73 A;  3EP9 B;  2VYV A;  3PWS A;  1H93 A;  1LC0 A;  4DIB A;  1P9L A;  3QV1 A;  1ZNQ O;  4PG5 A;  3WGY A;  4O59 O;  3K2B A;  2PH5 A;  1LC3 A;  2O4U X;  1RM4 A;  3WB9 A;  3RC9 A;  4GMG A;  3PZR A;  4XB2 A;  4DPL A;  1I79 B;  2DAP A;  1H6D A;  2YYY A;  1IHY A;  5GZ6 A;  3UW3 A;  1GD1 O;  4HAD A;  3VOS A;  4XQC A;  3HJA A;  1DRV A;  2GZ1 A;  3DZ5 B;  3QVS A;  4IQ8 A;  2EJW A;  4WNC A;  1DRW A;  4TVB A;  2YV3 A;  1I7B B;  3K9Q O;  4YWJ A;  1QXS A;  2XF8 A;  5A04 A;  3E5R A;  2VYV D;  4MIY A;  2IXA A;  3BIO A;  4ZHS A;  4MJL A;  1VC2 A;  1VKO A;  3ZJX A;  4XR4 A;  1EBU A;  4P8R A;  3WGZ A;  3MZ0 A;  1XEA A;  1VSU A;  3LC2 O;  4RL6 A;  5EER A;  1DSS G;  3L4S O;  4KOA A;  2BH9 A;  1CF2 O;  3Q11 A;  5A03 A;  4R5H A;  2BHL A;  3CEA A;  3EVN A;  1F06 A;  3RVD A;  4MVJ M;  3DMT C;  1E5Q A;  3GFG A;  1UYJ A;  1JN0 A;  3E1K A;  3ZDF A;  1SZJ G;  1YWG O;  1P1F A;  4GMF A;  4XQE A;  3LC1 O;  5C7O O;  2PKR A;  1I7C B;  3E18 A;  4BOY A;  4XRG A;  1QMI A;  4ZIC A;  5KVS A;  3EP6 B;  1ZH8 A;  4FB5 A;  5JW6 A;  3DOC A;  3OA2 A;  5GZ3 A;  2EP5 A;  2I5P O;  5AVO A;  1OFG A;  1CER A;  5C7L O;  1QMH A;  1RM0 A;  2Q22 A;  1T4D A;  4GPD 1;  3GPD G;  3GNQ A;  4LSM A;  1H6C A;  4QX6 A;  1LA2 A;  1JKI A;  3E9M A;  5J9G A;  3QVX A;  5A02 A;  4R54 A;  1PS8 A;  2DC1 A;  2DBV O;  5EES A;  5DDI P;  3KSZ O;  3EUW A;  4R4J A;  1EBF A;  4WNI A;  1PQU A;  3NTQ A;  1NWC A;  1NQA O;  2GD1 O;  3PYL A;  3V1Y A;  3F4L A;  1YL5 A;  4O89 A;  4H3V A;  1JKF A;  3B1K A;  5A05 A;  1TB4 A;  1H6A A;  3DAP A;  5GZ1 A;  3OA0 A;  1VM6 A;  1U1I A;  1E77 A;  2HKI A;  4MVJ P;  2O48 X;  1U8F O;  3NTR A;  3GDO A;  3BTV A;  3CIN A;  3U3X A;  1GYQ A;  3IWD B;  4GQA A;  2POQ X;  1GPD G;  4LRT B;  5M6D A;  5CEF A;  4R51 A;  1BRM A;  3EP3 B;  4AK1 A;  3V5N A;  1RM5 A;  3NT5 A;  2X5K O;  4LGV A;  3C8M A;  1FF9 A;  3BTU A;  1YS4 A;  3EPA B;  3VAZ A;  3EP8 B;  3CIF A;  1OBF O;  2GLX A;  2AXQ A;  2CVO A;  5JYE A;  1H9A A;  1E5L A;  2HO5 A;  4PG7 A;  3CPS A;  1C3V A;  1K3T A;  3TZ6 A;  2EP7 A;  2R00 A;  4EW6 A;  4IQ0 A;  3DB2 A;  4DPK A;  4II7 A;  1RM3 A;  2FPN A;  1RYE A;  2Q4E A;  1MC4 A;  4K9D A;  3HQ4 O;  4R3W A;  1IHX A;  2GZ3 A;  5JYA A;  3H0W B;  3WBF A;  3HNP A;  3HXL A;  3Q2I A;  3Q2K A;  2IXB A;  3Q1L A;  4LRS B;  5JY6 A;  3TW3 A;  1Q2X A;  1E7M A;  3ING A;  2X0N A;  3B20 A;  4L9R A;  3DZ4 B;  3OHS X;  1JEN B;  3L0D A;  2D2I A;  1DC5 A;  1H94 A;  4MIO A;  2X5J O;  3IJP A;  3DBV O;  1QKI A;  3RC2 A;  2PKQ O;  1GYP A;  1NVM B;  3HSK A;  3PYM A;  3DZ6 B;  1DC4 A;  2G17 A;  4DPM A;  5JYF A;  4O8J A;  1GL3 A;  5EIN A;  1RYD A;  1ML3 A;  1GAE O;  1P1J A;  3RC1 A;  4HKT A;  1TA4 A;  2B4R O;  3QVT A;  4MVJ F;  2B4T O;  1P1H A;  3ABI A;  1DC6 A;  3B1J A;  1GAD O;  3PWK A; 
#chains in the Genus database with same CATH homology
 3EP8 A;  1MSV A;  1I7C B;  1I7C A;  1MHM B;  1MHM A;  3DZ2 B;  3DZ5 B;  3DZ6 B;  3DZ7 B;  3DZ6 A;  3EPB B;  3DZ2 A;  3EPB A;  3DZ5 A;  3DZ7 A;  1VR7 A;  1I72 B;  1I7M B;  1I72 A;  1I7M A;  3EP4 B;  1I79 B;  3EP6 B;  3EP4 A;  3EP3 B;  1I79 A;  3DZ4 B;  3EP6 A;  3EP9 B;  3EP3 A;  1JEN B;  3DZ4 A;  3EP5 B;  1JL0 A;  3EP5 A;  3EP9 A;  1JEN A;  3H0W B;  1I7B A;  1I7B B;  3H0V B;  1TMI A;  3H0V A;  1TLU A;  3EP7 B;  3EP7 A;  3DZ3 B;  5TVO B;  2III A;  3EPA B;  3DZ3 A;  5TVO A;  3EPA A;  3EP8 B;  3H0W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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