1I7MB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with 4-amidinoindan-1-one-2'-amidinohydrazone
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
64
structure length
57
Chain Sequence
AHFFEGTEKLLEVWFSRGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 8
structure length 57
sequence length 64
chains with identical sequence D
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-09
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7mB01
1MHMB 1JENB 3DZ6B 3EPAB 1I7BB 1I7MB 3EP8B 3EP9B 3DZ2B 3H0VB 3EP6B 5TVOB 3EP5B 3DZ3B 3EP3B 3DZ7B 3EPBB 3DZ4B 3DZ5B 3H0WB 3EP4B 1I79B 1I72B 1I7CB 3EP7B
chains in the Genus database with same CATH superfamily
4DPMA 1NBOA 1H2HA 2I3AA 1E7MA 4F3YA 5JYFA 4ZHSA 3WYCA 1QKIA 1T4DA 3TUXA 4MVJP 1H9BA 1CRWG 1GADO 2DBVO 1GYQA 1P1IA 4L9RA 2H63A 3DAPA 4LGVA 5EIOA 1GL3A 1JKFA 4LRSB 2HO5A 3PYLA 1YS4A 1DIHA 1E7YA 3JSAA 5DDIP 1H6CA 5TVOB 5BNTA 3L0DA 1RM5A 1VKNA 4O8JA 4GMGA 1OBFO 1DRUA 2GYYA 1NQOA 3H0WB 1VSUA 3OA0A 4O63O 3BIOA 1H94A 1NPTO 1I7BB 1XEAA 3WGZA 5A03A 3NT2A 3DZ2B 1DC5A 2PKQO 1A7KA 1QMIA 4N54A 3DZ3B 1PS8A 1CF2O 3I23A 4PG8A 1NWCA 3LC1O 3B20A 3KUXA 4PLPA 3EC7A 3DMTA 3VOSA 3EP9B 2IXBA 3OHSX 1VC2A 5GZ1A 4GMFA 3CEAA 3H0VB 4LSMA 4DBVO 1YDWA 3PZBA 1VM6A 4MJLA 4P8RA 3UW3A 2X5JO 4EW6A 3OQBA 5A02A 3NT5A 2R00C 2AXQA 1ML3A 2I5PO 1E5QA 1RM3A 2FPNA 3RC1A 1F06A 4K9DA 1TVEA 3E9MA 4XB1A 3FHLA 3K73O 3NTRA 3HQ4O 3K9QO 4AK1A 3GFGA 5GZ3A 3DOCA 3EP6B 4MKXA 3PQVA 1FF9A 4KOAA 4XR4A 3WBFA 4JN6B 1I32A 3E5RA 3DZ7B 1H9AA 1P1JA 1U1IA 3FD8A 4H3VA 1MC4A 1SZJG 1JENB 4MIEA 3MOIA 4XB2A 1XYGA 3E1KA 1DC6A 1H93A 3VAZA 1NX6A 3HNPA 3QY9A 2PKRA 1P1FA 2OZPA 3LVFO 1PQPA 5KVSA 1RYDA 4MVJE 3C8MA 1DRWA 3Q11A 2POQX 4MIYA 1J5PA 2Q22A 3CMCO 2GZ1A 4PG4A 4IQ0A 3V5NA 1YWGO 3STHA 2Q49A 3DZ6B 3IWBB 3BTUA 3CPSA 1BRMA 2DUUA 1EBFA 5M6DA 1ARZA 4CLQA 3QVWA 3KSDO 1T4BA 3Q2KA 4LRTB 1DC4A 3WGQA 3B1KA 3IWDB 4L8VA 1PU2A 3EP3B 5CEFA 3DZ4B 4ZICA 5A04A 4TVBA 3TV1A 4R4JA 3E18A 3IJPA 4Z0HO 4R5MA 5T73A 5A06A 4R54A 1JN0A 3WGYA 4NHEA 3QVSA 3EP8B 4XQEA 3BTSA 2GD1O 1UYJA 2O48X 2GZ3A 4HADA 3PFWO 4RL6A 5C7OO 4R3WA 4O59O 1GR0A 2YV3A 3GPDG 5AQ1A 2X0NA 5C7IO 2YYYA 4MVJA 2CVOA 3KGDA 3Q1LA 3E82A 4FB5A 1NQAO 1J0XO 1JKIA 3B1JA 3DB2A 4MINA 3EP7B 1K3TA 4GPD1 3F4LA 1EBUA 1PR3A 1RYEA 3GDOA 1VKOA 3EUWA 4R51A 1RM4A 3ZJXA 1PQUA 3NT4A 1DSSG 1DBVO 2B4TO 3DTYA 5JYEA 3NTOA 3EP4B 4IQ8A 4WNIA 2DAPA 3V2UA 5JW6A 1LC0A 1LA2A 3EZYA 1B7GO 3IP3A 3L6OO 3O9ZA 4YWJA 5KVQA 2DC1A 3M2TA 4PG6A 3V1YA 1QMHA 2CZCA 1Q2XA 3MZ0A 1DPGA 4DPLA 3Q0EA 4MVJD 3GNQA 2EP7A 3HJAA 2VYNA 3IDSA 1GAEO 1TB4A 4MVJF 3WB9A 1DRVA 1RM0A 3CIFA 1P1HA 3OA2A 3PWKA 5A05A 2PH5A 4II7A 3TW3A 3RC7A 5EERA 5EESA 3RBVA 3TZ6A 3QVXA 1GPDG 3E6AA 2BHLA 1OZAA 3KSZO 3RCBA 4MVJG 1MHMB 4PG5A 2X5KO 3QV1A 5JYAA 3H9EO 4PG7A 5J9GA 2QZ9A 2P2SA 4MIOA 3IWCB 1NVMB 5C7LO 1E77A 1LC3A 3WGOA 1P1KA 1E5LA 3PYMA 3HXLA 4WOJA 3INGA 3L4SO 3RVDA 1I79B 4MVJM 1I72B 3PZRA 2EJWA 5EINA 1HDGO 1I7MB 4O89A 3K2BA 1GCUA 2PKQP 2GZ2A 3LC2O 1VSVA 3DR3A 2VYVA 3WBBA 5AVOA 2O4UX 3ZCXA 3NTQA 3QVTA 3BTVA 1EVJA 1MB4A 2VYND 4MVJH 4XRGA 3U3XA 3LC7O 1YL5A 1TA4A 2NQTA 4QX6A 3UUWA 3ZDFA 1Q7GA 4XQGA 3C1AA 2DPGA 3MTJA 3DMTC 3RC2A 3EVNA 1NWHA 4R5HA 3RC9A 1C3VA 2GLXA 4DIBA 1YL6A 1TLTA 5GZ6A 1ZNQO 4R3NA 3EP5B 4BOYA 1GYPA 1H6DA 2G17A 3DZ5B 2EP5A 1I7CB 1YL7A 3KV3O 3EPAB 1IHYA 5JY6A 4R41A 2Q4EA 1QXSA 1CERA 1IHXA 1ZH8A 2NVWA 2HKIA 4XQCA 1I33A 2XF8A 4XQ9A 1DC3A 4GQAA 4WNCA 3PYXA 3EPBB 4INAA 3ABIA 3Q2IA 4DPKA 2R00A 2BH9A 2VYVD 3CINA 3DBVO 3HSKA 1NQ5A 4MVJI 2HJSA 3QW2A 2D2IA 4MKZA 1OFGA 1S7CA 4YDRA 3TUTA 1U8FO 3PWSA 3DO5A 1DAPA 1P9LA 1GD1O 3WYBA 2IXAA 2I3GA 4HKTA 1H6BA 1H6AA 2B4RO 2G82A
chains in the Genus database with same CATH topology
1MHMB 3DZ3A 3EP5A 1JENB 3DZ6B 3EPAB 1I7BB 1I7MB 3EP8B 3EP3A 3DZ5A 3DZ7A 3EP9B 3EPBA 3DZ4A 3H0WA 3EP4A 1I79A 1I7CA 1I72A 1TMIA 3DZ2B 1JENA 1MHMA 3DZ6A 3EP7A 1I7MA 3H0VB 3EP6B 3EPAA 1I7BA 3EP9A 3EP8A 5TVOB 3EP5B 3DZ3B 3DZ2A 1JL0A 3EP3B 3DZ7B 3EPBB 3H0VA 1MSVA 3DZ4B 3EP6A 3DZ5B 3H0WB 3EP4B 5TVOA 1I79B 1TLUA 1VR7A 2IIIA 1I72B 1I7CB 3EP7B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MHM B;  1JEN B;  3DZ6 B;  3EPA B;  1I7B B;  1I7M B;  3EP8 B;  3EP9 B;  3DZ2 B;  3H0V B;  3EP6 B;  5TVO B;  3EP5 B;  3DZ3 B;  3EP3 B;  3DZ7 B;  3EPB B;  3DZ4 B;  3DZ5 B;  3H0W B;  3EP4 B;  1I79 B;  1I72 B;  1I7C B;  3EP7 B; 
#chains in the Genus database with same CATH topology
 4DPM A;  1NBO A;  1H2H A;  2I3A A;  1E7M A;  4F3Y A;  5JYF A;  4ZHS A;  3WYC A;  1QKI A;  1T4D A;  3TUX A;  4MVJ P;  1H9B A;  1CRW G;  1GAD O;  2DBV O;  1GYQ A;  1P1I A;  4L9R A;  2H63 A;  3DAP A;  4LGV A;  5EIO A;  1GL3 A;  1JKF A;  4LRS B;  2HO5 A;  3PYL A;  1YS4 A;  1DIH A;  1E7Y A;  3JSA A;  5DDI P;  1H6C A;  5TVO B;  5BNT A;  3L0D A;  1RM5 A;  1VKN A;  4O8J A;  4GMG A;  1OBF O;  1DRU A;  2GYY A;  1NQO A;  3H0W B;  1VSU A;  3OA0 A;  4O63 O;  3BIO A;  1H94 A;  1NPT O;  1I7B B;  1XEA A;  3WGZ A;  5A03 A;  3NT2 A;  3DZ2 B;  1DC5 A;  2PKQ O;  1A7K A;  1QMI A;  4N54 A;  3DZ3 B;  1PS8 A;  1CF2 O;  3I23 A;  4PG8 A;  1NWC A;  3LC1 O;  3B20 A;  3KUX A;  4PLP A;  3EC7 A;  3DMT A;  3VOS A;  3EP9 B;  2IXB A;  3OHS X;  1VC2 A;  5GZ1 A;  4GMF A;  3CEA A;  3H0V B;  4LSM A;  4DBV O;  1YDW A;  3PZB A;  1VM6 A;  4MJL A;  4P8R A;  3UW3 A;  2X5J O;  4EW6 A;  3OQB A;  5A02 A;  3NT5 A;  2R00 C;  2AXQ A;  1ML3 A;  2I5P O;  1E5Q A;  1RM3 A;  2FPN A;  3RC1 A;  1F06 A;  4K9D A;  1TVE A;  3E9M A;  4XB1 A;  3FHL A;  3K73 O;  3NTR A;  3HQ4 O;  3K9Q O;  4AK1 A;  3GFG A;  5GZ3 A;  3DOC A;  3EP6 B;  4MKX A;  3PQV A;  1FF9 A;  4KOA A;  4XR4 A;  3WBF A;  4JN6 B;  1I32 A;  3E5R A;  3DZ7 B;  1H9A A;  1P1J A;  1U1I A;  3FD8 A;  4H3V A;  1MC4 A;  1SZJ G;  1JEN B;  4MIE A;  3MOI A;  4XB2 A;  1XYG A;  3E1K A;  1DC6 A;  1H93 A;  3VAZ A;  1NX6 A;  3HNP A;  3QY9 A;  2PKR A;  1P1F A;  2OZP A;  3LVF O;  1PQP A;  5KVS A;  1RYD A;  4MVJ E;  3C8M A;  1DRW A;  3Q11 A;  2POQ X;  4MIY A;  1J5P A;  2Q22 A;  3CMC O;  2GZ1 A;  4PG4 A;  4IQ0 A;  3V5N A;  1YWG O;  3STH A;  2Q49 A;  3DZ6 B;  3IWB B;  3BTU A;  3CPS A;  1BRM A;  2DUU A;  1EBF A;  5M6D A;  1ARZ A;  4CLQ A;  3QVW A;  3KSD O;  1T4B A;  3Q2K A;  4LRT B;  1DC4 A;  3WGQ A;  3B1K A;  3IWD B;  4L8V A;  1PU2 A;  3EP3 B;  5CEF A;  3DZ4 B;  4ZIC A;  5A04 A;  4TVB A;  3TV1 A;  4R4J A;  3E18 A;  3IJP A;  4Z0H O;  4R5M A;  5T73 A;  5A06 A;  4R54 A;  1JN0 A;  3WGY A;  4NHE A;  3QVS A;  3EP8 B;  4XQE A;  3BTS A;  2GD1 O;  1UYJ A;  2O48 X;  2GZ3 A;  4HAD A;  3PFW O;  4RL6 A;  5C7O O;  4R3W A;  4O59 O;  1GR0 A;  2YV3 A;  3GPD G;  5AQ1 A;  2X0N A;  5C7I O;  2YYY A;  4MVJ A;  2CVO A;  3KGD A;  3Q1L A;  3E82 A;  4FB5 A;  1NQA O;  1J0X O;  1JKI A;  3B1J A;  3DB2 A;  4MIN A;  3EP7 B;  1K3T A;  4GPD 1;  3F4L A;  1EBU A;  1PR3 A;  1RYE A;  3GDO A;  1VKO A;  3EUW A;  4R51 A;  1RM4 A;  3ZJX A;  1PQU A;  3NT4 A;  1DSS G;  1DBV O;  2B4T O;  3DTY A;  5JYE A;  3NTO A;  3EP4 B;  4IQ8 A;  4WNI A;  2DAP A;  3V2U A;  5JW6 A;  1LC0 A;  1LA2 A;  3EZY A;  1B7G O;  3IP3 A;  3L6O O;  3O9Z A;  4YWJ A;  5KVQ A;  2DC1 A;  3M2T A;  4PG6 A;  3V1Y A;  1QMH A;  2CZC A;  1Q2X A;  3MZ0 A;  1DPG A;  4DPL A;  3Q0E A;  4MVJ D;  3GNQ A;  2EP7 A;  3HJA A;  2VYN A;  3IDS A;  1GAE O;  1TB4 A;  4MVJ F;  3WB9 A;  1DRV A;  1RM0 A;  3CIF A;  1P1H A;  3OA2 A;  3PWK A;  5A05 A;  2PH5 A;  4II7 A;  3TW3 A;  3RC7 A;  5EER A;  5EES A;  3RBV A;  3TZ6 A;  3QVX A;  1GPD G;  3E6A A;  2BHL A;  1OZA A;  3KSZ O;  3RCB A;  4MVJ G;  1MHM B;  4PG5 A;  2X5K O;  3QV1 A;  5JYA A;  3H9E O;  4PG7 A;  5J9G A;  2QZ9 A;  2P2S A;  4MIO A;  3IWC B;  1NVM B;  5C7L O;  1E77 A;  1LC3 A;  3WGO A;  1P1K A;  1E5L A;  3PYM A;  3HXL A;  4WOJ A;  3ING A;  3L4S O;  3RVD A;  1I79 B;  4MVJ M;  1I72 B;  3PZR A;  2EJW A;  5EIN A;  1HDG O;  1I7M B;  4O89 A;  3K2B A;  1GCU A;  2PKQ P;  2GZ2 A;  3LC2 O;  1VSV A;  3DR3 A;  2VYV A;  3WBB A;  5AVO A;  2O4U X;  3ZCX A;  3NTQ A;  3QVT A;  3BTV A;  1EVJ A;  1MB4 A;  2VYN D;  4MVJ H;  4XRG A;  3U3X A;  3LC7 O;  1YL5 A;  1TA4 A;  2NQT A;  4QX6 A;  3UUW A;  3ZDF A;  1Q7G A;  4XQG A;  3C1A A;  2DPG A;  3MTJ A;  3DMT C;  3RC2 A;  3EVN A;  1NWH A;  4R5H A;  3RC9 A;  1C3V A;  2GLX A;  4DIB A;  1YL6 A;  1TLT A;  5GZ6 A;  1ZNQ O;  4R3N A;  3EP5 B;  4BOY A;  1GYP A;  1H6D A;  2G17 A;  3DZ5 B;  2EP5 A;  1I7C B;  1YL7 A;  3KV3 O;  3EPA B;  1IHY A;  5JY6 A;  4R41 A;  2Q4E A;  1QXS A;  1CER A;  1IHX A;  1ZH8 A;  2NVW A;  2HKI A;  4XQC A;  1I33 A;  2XF8 A;  4XQ9 A;  1DC3 A;  4GQA A;  4WNC A;  3PYX A;  3EPB B;  4INA A;  3ABI A;  3Q2I A;  4DPK A;  2R00 A;  2BH9 A;  2VYV D;  3CIN A;  3DBV O;  3HSK A;  1NQ5 A;  4MVJ I;  2HJS A;  3QW2 A;  2D2I A;  4MKZ A;  1OFG A;  1S7C A;  4YDR A;  3TUT A;  1U8F O;  3PWS A;  3DO5 A;  1DAP A;  1P9L A;  1GD1 O;  3WYB A;  2IXA A;  2I3G A;  4HKT A;  1H6B A;  1H6A A;  2B4R O;  2G82 A; 
#chains in the Genus database with same CATH homology
 1MHM B;  3DZ3 A;  3EP5 A;  1JEN B;  3DZ6 B;  3EPA B;  1I7B B;  1I7M B;  3EP8 B;  3EP3 A;  3DZ5 A;  3DZ7 A;  3EP9 B;  3EPB A;  3DZ4 A;  3H0W A;  3EP4 A;  1I79 A;  1I7C A;  1I72 A;  1TMI A;  3DZ2 B;  1JEN A;  1MHM A;  3DZ6 A;  3EP7 A;  1I7M A;  3H0V B;  3EP6 B;  3EPA A;  1I7B A;  3EP9 A;  3EP8 A;  5TVO B;  3EP5 B;  3DZ3 B;  3DZ2 A;  1JL0 A;  3EP3 B;  3DZ7 B;  3EPB B;  3H0V A;  1MSV A;  3DZ4 B;  3EP6 A;  3DZ5 B;  3H0W B;  3EP4 B;  5TVO A;  1I79 B;  1TLU A;  1VR7 A;  2III A;  1I72 B;  1I7C B;  3EP7 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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