1I79B

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and covalently bound 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
Total Genus 7
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 7
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i79B01
3DZ3B 3H0VB 3EP8B 1JENB 1I7BB 1I79B 5TVOB 3DZ6B 1I7MB 3DZ7B 1I7CB 3DZ4B 1MHMB 3EP6B 3EPBB 3EP3B 3EP4B 3EP5B 3DZ5B 3EPAB 3EP9B 3EP7B 3H0WB 1I72B 3DZ2B
chains in the Genus database with same CATH superfamily
3DZ3B 1B7GO 4MVJE 2X0NA 3PZRA 2EJWA 3L6OO 1NX6A 1I7CB 3EVNA 1U8FO 4MVJA 3Q2KA 3EPBB 3WGOA 3WGZA 4MJLA 1H2HA 2HO5A 3QVSA 4R3NA 2HJSA 4Z0HO 2IXAA 1A7KA 4MVJP 3H9EO 2NQTA 1OZAA 2GZ2A 3DMTC 4GMGA 1S7CA 3C8MA 2GD1O 4XB2A 4PG6A 1BRMA 4DBVO 2QZ9A 4R54A 1PS8A 1H6CA 1RYDA 1JN0A 3DZ5B 2X5JO 3CEAA 1T4BA 3CMCO 3WBBA 3EP9B 2VYND 2POQX 3H0WB 4NHEA 2Q22A 1LC0A 3DOCA 4JN6B 3IJPA 3WYBA 1HDGO 4MVJG 1E77A 5KVQA 3IWDB 4XR4A 3B1JA 2GZ3A 2PKRA 3RC9A 3TW3A 1MC4A 1RYEA 3WYCA 1DRVA 2Q49A 1DIHA 3HXLA 3HSKA 1CRWG 4O89A 3PQVA 3CINA 4II7A 1EBUA 2DUUA 3EC7A 1H94A 3MOIA 1VM6A 3ABIA 1LC3A 4LRTB 5TVOB 3B1KA 1J5PA 4MIOA 4PLPA 5JW6A 2VYVD 4R5MA 1I32A 5A02A 4HADA 3PYMA 3KSZO 4MKZA 3PWKA 1GYPA 2CVOA 3BTSA 1OFGA 3PFWO 1ZH8A 3RCBA 3E18A 3EP8B 1DC4A 3PZBA 3OHSX 2VYVA 3LC2O 1ML3A 3K73O 3DB2A 4DPLA 1YDWA 3TZ6A 3GNQA 3B20A 3EP4B 4YDRA 2XF8A 1NWHA 5GZ1A 1DPGA 3HJAA 4RL6A 5EESA 1TLTA 3DAPA 3GDOA 1P1HA 3FHLA 1EBFA 3V1YA 2NVWA 1DC5A 3QY9A 3DZ6B 5C7IO 1P1FA 2GZ1A 1H6BA 1K3TA 4IQ8A 4WOJA 4XQCA 2BHLA 5CEFA 2BH9A 3M2TA 4MKXA 5A04A 1YS4A 1QKIA 1NBOA 3EUWA 3UUWA 3ZJXA 1XEAA 4GMFA 2DBVO 3DTYA 4PG8A 4L9RA 3TV1A 1GAEO 5GZ6A 5BNTA 2PKQP 2I3AA 1VC2A 1YL7A 1NQAO 1E5LA 4ZICA 4MIEA 2R00C 1QMIA 3FD8A 3NT4A 1DBVO 3LC7O 3BIOA 3E5RA 3TUXA 4TVBA 2I5PO 1RM4A 4MVJH 5C7OO 1JENB 2O48X 2PKQO 3RC1A 1YL6A 3BTVA 3PWSA 1H9BA 1CERA 5EINA 2GLXA 3Q0EA 1NQ5A 4N54A 1E7YA 3LC1O 3BTUA 5A03A 1OBFO 3KGDA 4BOYA 5J9GA 1H6DA 4PG5A 4XQGA 1E7MA 3DZ2B 1DSSG 3HNPA 3V2UA 1VSVA 4R51A 3Q11A 4LSMA 3LVFO 3DMTA 1DC6A 1MB4A 4GQAA 4QX6A 3JSAA 1CF2O 5DDIP 4LRSB 2R00A 1H93A 3ZDFA 3WBFA 4L8VA 3L0DA 4MVJF 5KVSA 3VAZA 4GPD1 1JKIA 3L4SO 2O4UX 3WGQA 1QXSA 2B4TO 1GR0A 1DAPA 4P8RA 2OZPA 3GFGA 4XQ9A 2B4RO 3PYXA 4K9DA 1NWCA 1ARZA 1EVJA 5JYAA 2YV3A 3Q2IA 1NQOA 3C1AA 3IP3A 3KV3O 1DRUA 1VKNA 2AXQA 3EP6B 1DC3A 5EIOA 4F3YA 2G82A 4INAA 4O59O 4HKTA 1T4DA 3NTRA 3VOSA 1VSUA 1GYQA 2DAPA 5EERA 1I7BB 3IWCB 4PG7A 2DC1A 4EW6A 4AK1A 4KOAA 3DZ4B 1MHMB 5JYEA 2P2SA 2IXBA 3WGYA 4XB1A 3E6AA 5T73A 1RM3A 1H9AA 1RM0A 3KUXA 3F4LA 5A05A 3QVXA 3WB9A 1YL5A 1P1IA 3GPDG 3RBVA 3I23A 3E82A 1I7MB 3RVDA 1I33A 1PQUA 1U1IA 4DPMA 3CIFA 1P9LA 1GCUA 1YWGO 4H3VA 4XRGA 3QVTA 5AQ1A 3KSDO 1F06A 2X5KO 2D2IA 2I3GA 1DRWA 1P1KA 1LA2A 3EZYA 4DPKA 3O9ZA 1NVMB 1E5QA 2H63A 3NTQA 1PR3A 3QV1A 1J0XO 4MVJM 4MVJI 4O8JA 1IHXA 3QVWA 3IWBB 1Q2XA 3CPSA 2EP5A 3K2BA 3EPAB 3NTOA 3INGA 4DIBA 4LGVA 3E1KA 3QW2A 3PYLA 3OQBA 1UYJA 1TA4A 5A06A 3MTJA 2DPGA 3Q1LA 3OA2A 4FB5A 1GL3A 5JYFA 2VYNA 3EP5B 4CLQA 3RC2A 1H6AA 5M6DA 2FPNA 3DR3A 3V5NA 3DO5A 4MINA 4R5HA 3UW3A 3NT2A 4WNCA 1I72B 2G17A 4ZHSA 3K9QO 2CZCA 4WNIA 1TVEA 1XYGA 1NPTO 4MIYA 1I79B 1IHYA 5JY6A 2HKIA 3DZ7B 3HQ4O 3STHA 3ZCXA 4IQ0A 2EP7A 3OA0A 3MZ0A 4R4JA 1VKOA 5AVOA 1RM5A 1SZJG 3E9MA 4YWJA 3RC7A 2PH5A 1ZNQO 4XQEA 1Q7GA 3H0VB 1TB4A 1GD1O 1QMHA 4PG4A 2GYYA 4O63O 4R41A 3NT5A 5GZ3A 1PQPA 3EP3B 4R3WA 2Q4EA 2YYYA 1PU2A 4MVJD 5C7LO 3DBVO 3TUTA 1P1JA 3IDSA 1GPDG 1GADO 1FF9A 3U3XA 1C3VA 3EP7B 1JKFA
chains in the Genus database with same CATH topology
3EP5A 3DZ3B 3H0VB 3DZ5A 3EP8B 1JENB 3EPAA 1I7BB 1I79B 5TVOB 3EP9A 3EP7A 3DZ6B 1I7MB 3DZ7B 1I72A 3H0WA 3DZ2A 3DZ3A 3H0VA 3EP8A 1I7CB 3DZ4B 1JENA 1MHMB 1VR7A 3EP6B 3EPBB 1I7BA 1I79A 3EP3B 3EP4B 5TVOA 3DZ6A 1I7MA 3DZ7A 3EP5B 3DZ5B 1TLUA 3DZ4A 1MSVA 3EPAB 1I7CA 1MHMA 3EP9B 2IIIA 3EP6A 3EPBA 3EP3A 3EP4A 3EP7B 1JL0A 3H0WB 1I72B 3DZ2B 1TMIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ3 B;  3H0V B;  3EP8 B;  1JEN B;  1I7B B;  1I79 B;  5TVO B;  3DZ6 B;  1I7M B;  3DZ7 B;  1I7C B;  3DZ4 B;  1MHM B;  3EP6 B;  3EPB B;  3EP3 B;  3EP4 B;  3EP5 B;  3DZ5 B;  3EPA B;  3EP9 B;  3EP7 B;  3H0W B;  1I72 B;  3DZ2 B; 
#chains in the Genus database with same CATH topology
 3DZ3 B;  1B7G O;  4MVJ E;  2X0N A;  3PZR A;  2EJW A;  3L6O O;  1NX6 A;  1I7C B;  3EVN A;  1U8F O;  4MVJ A;  3Q2K A;  3EPB B;  3WGO A;  3WGZ A;  4MJL A;  1H2H A;  2HO5 A;  3QVS A;  4R3N A;  2HJS A;  4Z0H O;  2IXA A;  1A7K A;  4MVJ P;  3H9E O;  2NQT A;  1OZA A;  2GZ2 A;  3DMT C;  4GMG A;  1S7C A;  3C8M A;  2GD1 O;  4XB2 A;  4PG6 A;  1BRM A;  4DBV O;  2QZ9 A;  4R54 A;  1PS8 A;  1H6C A;  1RYD A;  1JN0 A;  3DZ5 B;  2X5J O;  3CEA A;  1T4B A;  3CMC O;  3WBB A;  3EP9 B;  2VYN D;  2POQ X;  3H0W B;  4NHE A;  2Q22 A;  1LC0 A;  3DOC A;  4JN6 B;  3IJP A;  3WYB A;  1HDG O;  4MVJ G;  1E77 A;  5KVQ A;  3IWD B;  4XR4 A;  3B1J A;  2GZ3 A;  2PKR A;  3RC9 A;  3TW3 A;  1MC4 A;  1RYE A;  3WYC A;  1DRV A;  2Q49 A;  1DIH A;  3HXL A;  3HSK A;  1CRW G;  4O89 A;  3PQV A;  3CIN A;  4II7 A;  1EBU A;  2DUU A;  3EC7 A;  1H94 A;  3MOI A;  1VM6 A;  3ABI A;  1LC3 A;  4LRT B;  5TVO B;  3B1K A;  1J5P A;  4MIO A;  4PLP A;  5JW6 A;  2VYV D;  4R5M A;  1I32 A;  5A02 A;  4HAD A;  3PYM A;  3KSZ O;  4MKZ A;  3PWK A;  1GYP A;  2CVO A;  3BTS A;  1OFG A;  3PFW O;  1ZH8 A;  3RCB A;  3E18 A;  3EP8 B;  1DC4 A;  3PZB A;  3OHS X;  2VYV A;  3LC2 O;  1ML3 A;  3K73 O;  3DB2 A;  4DPL A;  1YDW A;  3TZ6 A;  3GNQ A;  3B20 A;  3EP4 B;  4YDR A;  2XF8 A;  1NWH A;  5GZ1 A;  1DPG A;  3HJA A;  4RL6 A;  5EES A;  1TLT A;  3DAP A;  3GDO A;  1P1H A;  3FHL A;  1EBF A;  3V1Y A;  2NVW A;  1DC5 A;  3QY9 A;  3DZ6 B;  5C7I O;  1P1F A;  2GZ1 A;  1H6B A;  1K3T A;  4IQ8 A;  4WOJ A;  4XQC A;  2BHL A;  5CEF A;  2BH9 A;  3M2T A;  4MKX A;  5A04 A;  1YS4 A;  1QKI A;  1NBO A;  3EUW A;  3UUW A;  3ZJX A;  1XEA A;  4GMF A;  2DBV O;  3DTY A;  4PG8 A;  4L9R A;  3TV1 A;  1GAE O;  5GZ6 A;  5BNT A;  2PKQ P;  2I3A A;  1VC2 A;  1YL7 A;  1NQA O;  1E5L A;  4ZIC A;  4MIE A;  2R00 C;  1QMI A;  3FD8 A;  3NT4 A;  1DBV O;  3LC7 O;  3BIO A;  3E5R A;  3TUX A;  4TVB A;  2I5P O;  1RM4 A;  4MVJ H;  5C7O O;  1JEN B;  2O48 X;  2PKQ O;  3RC1 A;  1YL6 A;  3BTV A;  3PWS A;  1H9B A;  1CER A;  5EIN A;  2GLX A;  3Q0E A;  1NQ5 A;  4N54 A;  1E7Y A;  3LC1 O;  3BTU A;  5A03 A;  1OBF O;  3KGD A;  4BOY A;  5J9G A;  1H6D A;  4PG5 A;  4XQG A;  1E7M A;  3DZ2 B;  1DSS G;  3HNP A;  3V2U A;  1VSV A;  4R51 A;  3Q11 A;  4LSM A;  3LVF O;  3DMT A;  1DC6 A;  1MB4 A;  4GQA A;  4QX6 A;  3JSA A;  1CF2 O;  5DDI P;  4LRS B;  2R00 A;  1H93 A;  3ZDF A;  3WBF A;  4L8V A;  3L0D A;  4MVJ F;  5KVS A;  3VAZ A;  4GPD 1;  1JKI A;  3L4S O;  2O4U X;  3WGQ A;  1QXS A;  2B4T O;  1GR0 A;  1DAP A;  4P8R A;  2OZP A;  3GFG A;  4XQ9 A;  2B4R O;  3PYX A;  4K9D A;  1NWC A;  1ARZ A;  1EVJ A;  5JYA A;  2YV3 A;  3Q2I A;  1NQO A;  3C1A A;  3IP3 A;  3KV3 O;  1DRU A;  1VKN A;  2AXQ A;  3EP6 B;  1DC3 A;  5EIO A;  4F3Y A;  2G82 A;  4INA A;  4O59 O;  4HKT A;  1T4D A;  3NTR A;  3VOS A;  1VSU A;  1GYQ A;  2DAP A;  5EER A;  1I7B B;  3IWC B;  4PG7 A;  2DC1 A;  4EW6 A;  4AK1 A;  4KOA A;  3DZ4 B;  1MHM B;  5JYE A;  2P2S A;  2IXB A;  3WGY A;  4XB1 A;  3E6A A;  5T73 A;  1RM3 A;  1H9A A;  1RM0 A;  3KUX A;  3F4L A;  5A05 A;  3QVX A;  3WB9 A;  1YL5 A;  1P1I A;  3GPD G;  3RBV A;  3I23 A;  3E82 A;  1I7M B;  3RVD A;  1I33 A;  1PQU A;  1U1I A;  4DPM A;  3CIF A;  1P9L A;  1GCU A;  1YWG O;  4H3V A;  4XRG A;  3QVT A;  5AQ1 A;  3KSD O;  1F06 A;  2X5K O;  2D2I A;  2I3G A;  1DRW A;  1P1K A;  1LA2 A;  3EZY A;  4DPK A;  3O9Z A;  1NVM B;  1E5Q A;  2H63 A;  3NTQ A;  1PR3 A;  3QV1 A;  1J0X O;  4MVJ M;  4MVJ I;  4O8J A;  1IHX A;  3QVW A;  3IWB B;  1Q2X A;  3CPS A;  2EP5 A;  3K2B A;  3EPA B;  3NTO A;  3ING A;  4DIB A;  4LGV A;  3E1K A;  3QW2 A;  3PYL A;  3OQB A;  1UYJ A;  1TA4 A;  5A06 A;  3MTJ A;  2DPG A;  3Q1L A;  3OA2 A;  4FB5 A;  1GL3 A;  5JYF A;  2VYN A;  3EP5 B;  4CLQ A;  3RC2 A;  1H6A A;  5M6D A;  2FPN A;  3DR3 A;  3V5N A;  3DO5 A;  4MIN A;  4R5H A;  3UW3 A;  3NT2 A;  4WNC A;  1I72 B;  2G17 A;  4ZHS A;  3K9Q O;  2CZC A;  4WNI A;  1TVE A;  1XYG A;  1NPT O;  4MIY A;  1I79 B;  1IHY A;  5JY6 A;  2HKI A;  3DZ7 B;  3HQ4 O;  3STH A;  3ZCX A;  4IQ0 A;  2EP7 A;  3OA0 A;  3MZ0 A;  4R4J A;  1VKO A;  5AVO A;  1RM5 A;  1SZJ G;  3E9M A;  4YWJ A;  3RC7 A;  2PH5 A;  1ZNQ O;  4XQE A;  1Q7G A;  3H0V B;  1TB4 A;  1GD1 O;  1QMH A;  4PG4 A;  2GYY A;  4O63 O;  4R41 A;  3NT5 A;  5GZ3 A;  1PQP A;  3EP3 B;  4R3W A;  2Q4E A;  2YYY A;  1PU2 A;  4MVJ D;  5C7L O;  3DBV O;  3TUT A;  1P1J A;  3IDS A;  1GPD G;  1GAD O;  1FF9 A;  3U3X A;  1C3V A;  3EP7 B;  1JKF A; 
#chains in the Genus database with same CATH homology
 3EP5 A;  3DZ3 B;  3H0V B;  3DZ5 A;  3EP8 B;  1JEN B;  3EPA A;  1I7B B;  1I79 B;  5TVO B;  3EP9 A;  3EP7 A;  3DZ6 B;  1I7M B;  3DZ7 B;  1I72 A;  3H0W A;  3DZ2 A;  3DZ3 A;  3H0V A;  3EP8 A;  1I7C B;  3DZ4 B;  1JEN A;  1MHM B;  1VR7 A;  3EP6 B;  3EPB B;  1I7B A;  1I79 A;  3EP3 B;  3EP4 B;  5TVO A;  3DZ6 A;  1I7M A;  3DZ7 A;  3EP5 B;  3DZ5 B;  1TLU A;  3DZ4 A;  1MSV A;  3EPA B;  1I7C A;  1MHM A;  3EP9 B;  2III A;  3EP6 A;  3EPB A;  3EP3 A;  3EP4 A;  3EP7 B;  1JL0 A;  3H0W B;  1I72 B;  3DZ2 B;  1TMI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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