1I7CB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with methylglyoxal bis-(guanylhydrazone)
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
64
structure length
61
Chain Sequence
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 9
structure length 61
sequence length 64
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7cB01
3DZ7B 3EP4B 3H0WB 3DZ3B 3EPBB 1I7BB 1I79B 3EP6B 3DZ6B 3EPAB 1I7MB 3DZ4B 3DZ2B 3EP3B 3EP7B 3DZ5B 5TVOB 1I72B 1MHMB 3EP8B 3EP9B 3EP5B 1I7CB 1JENB 3H0VB
chains in the Genus database with same CATH superfamily
1VKNA 1Q2XA 4R3NA 1GADO 2P2SA 3RC7A 2CZCA 1H9AA 3E18A 1RYEA 3PQVA 3C8MA 3OHSX 4R5MA 4MINA 1MHMB 5BNTA 4LSMA 1IHXA 2GZ3A 3H0WB 3INGA 2EJWA 1DC4A 2X5KO 3Q0EA 3DZ3B 1T4BA 1VSUA 4R3WA 3OQBA 4R54A 4YWJA 3DZ6B 4PG8A 4QX6A 3F4LA 1I7MB 1QMHA 3E6AA 4Z0HO 5A06A 2B4RO 1E77A 4MKZA 4EW6A 5M6DA 2PKQP 3HSKA 4FB5A 3TZ6A 3GFGA 5GZ1A 1YDWA 1GPDG 2GZ2A 3RC9A 3HNPA 4MVJD 3L0DA 4R51A 3PWSA 3U3XA 1CERA 2VYVD 2I5PO 3QW2A 1RM4A 1YL5A 1EVJA 4R5HA 3K2BA 5T73A 3IWBB 2I3AA 1H6DA 5JYFA 3UW3A 1DBVO 5A04A 1PQUA 4K9DA 4DPMA 4MIOA 4R4JA 3DAPA 2VYND 1TB4A 3MTJA 3FHLA 1MC4A 3ABIA 5C7IO 1GL3A 2IXAA 5GZ3A 3EP3B 2HJSA 4PG7A 1P1FA 4MKXA 1QKIA 1E7MA 2DPGA 1DC5A 3BTSA 3JSAA 1TLTA 4N54A 1OFGA 3NT2A 3EZYA 4XB1A 4WNIA 4XQ9A 4HKTA 3GDOA 3LC7O 2HKIA 4R41A 3WYBA 2AXQA 2DAPA 1DAPA 1QXSA 1QMIA 1EBFA 4GPD1 1CRWG 1E7YA 3NT4A 1XYGA 2G17A 2OZPA 4MVJE 2B4TO 4IQ8A 3IJPA 1I7BB 4XB2A 2NVWA 3DMTA 4GMGA 4DPLA 3PYMA 5EESA 2GZ1A 1VM6A 3B1KA 3WGYA 4L9RA 3EP8B 1NWHA 1RM0A 1H6CA 4WOJA 2H63A 1NVMB 3GPDG 1H94A 3H0VB 4PG6A 1PR3A 3PZRA 3EC7A 3LVFO 1HDGO 4O8JA 3QY9A 2YYYA 2Q49A 4GQAA 1YWGO 1DC3A 1NQOA 3ZCXA 2VYNA 3Q2IA 2PKRA 1NQAO 3V2UA 1LA2A 1K3TA 2GLXA 3QVTA 3B20A 1SZJG 4H3VA 3RVDA 1GAEO 3M2TA 3Q11A 1DRWA 3IWCB 2BH9A 1OZAA 3RC2A 1DIHA 2XF8A 3CPSA 1GCUA 3EP6B 1H9BA 3DBVO 4JN6B 5DDIP 1XEAA 1NPTO 3V5NA 1C3VA 3TV1A 1MB4A 3WB9A 3NTQA 3EP5B 3BIOA 3MOIA 3OA2A 1U8FO 5KVSA 5JYEA 2HO5A 4XQGA 1H93A 5JY6A 3E9MA 3O9ZA 4RL6A 4IQ0A 1B7GO 1F06A 3HXLA 1YL6A 3WBFA 3TW3A 3L4SO 4LRTB 1DRUA 4PLPA 1CF2O 3NTOA 4DIBA 1NQ5A 2QZ9A 2NQTA 3IWDB 1J0XO 2EP5A 5JW6A 1I33A 3RCBA 1VC2A 4XQEA 3EPBB 1JKIA 2FPNA 2R00A 3I23A 1VSVA 1Q7GA 1P9LA 2O4UX 3DB2A 3VOSA 3QV1A 1PS8A 3L6OO 1GYPA 4AK1A 3VAZA 3EP9B 4LRSB 3E5RA 3DMTC 5A03A 4MJLA 1E5QA 3HQ4O 1P1JA 3BTUA 1S7CA 3IP3A 3CEAA 1YL7A 3QVSA 4MIYA 3PYXA 3CIFA 5GZ6A 1DSSG 3UUWA 4MVJA 3STHA 3WGOA 3DZ4B 1PQPA 1DRVA 2VYVA 5KVQA 3LC1O 4XQCA 3GNQA 1DC6A 2GD1O 1P1IA 1A7KA 1BRMA 4MVJP 1H2HA 1H6BA 1VKOA 4O89A 3K73O 1JKFA 4II7A 1RYDA 2BHLA 1P1HA 1PU2A 3K9QO 3MZ0A 2DUUA 3WBBA 4MVJH 1GR0A 1GD1O 3PWKA 4O63O 4TVBA 5J9GA 4CLQA 3B1JA 4F3YA 5EERA 1YS4A 3KGDA 4O59O 3EPAB 5A05A 3V1YA 1FF9A 3PYLA 3QVXA 4YDRA 3WGZA 5TVOB 2D2IA 1H6AA 4NHEA 2X0NA 3H9EO 3TUTA 5C7LO 3WYCA 3WGQA 1ZNQO 2PKQO 1LC0A 4MIEA 3CMCO 3Q2KA 5A02A 2O48X 3ZDFA 1ML3A 1OBFO 2DBVO 3EP7B 3PFWO 3CINA 3DZ5B 3E82A 5EIOA 5CEFA 1E5LA 3ZJXA 3FD8A 4XRGA 4ZHSA 2PH5A 1I7CB 3KSDO 4XR4A 3NT5A 1RM5A 4L8VA 3DOCA 3PZBA 3RBVA 1NWCA 3EVNA 4ZICA 5JYAA 3E1KA 1P1KA 2YV3A 3KUXA 2G82A 3DR3A 4HADA 2CVOA 4MVJF 2POQX 3QVWA 2R00C 5AQ1A 1LC3A 1I72B 5AVOA 2DC1A 1RM3A 1T4DA 4PG5A 3DZ7B 3IDSA 1TVEA 4DPKA 1NX6A 4MVJG 1I32A 3KV3O 3HJAA 4WNCA 3DO5A 3RC1A 3C1AA 1NBOA 4INAA 1EBUA 4BOYA 5EINA 2Q22A 2IXBA 2X5JO 4DBVO 2I3GA 1TA4A 3Q1LA 3TUXA 1JN0A 2Q4EA 3EP4B 3KSZO 5C7OO 2GYYA 3DTYA 3BTVA 3EUWA 1I79B 4LGVA 1IHYA 4P8RA 2EP7A 3OA0A 3LC2O 4PG4A 3DZ2B 1UYJA 1ZH8A 4MVJI 1GYQA 4KOAA 1J5PA 1ARZA 3NTRA 1DPGA 4MVJM 1U1IA 1JENB 4GMFA
chains in the Genus database with same CATH topology
3DZ7B 3EP4A 3EP4B 3H0WB 3DZ3B 3DZ3A 3EPBA 3EPBB 1I7BA 1I7BB 1I79A 1I79B 1MSVA 3DZ6A 3EP6B 3EP6A 3DZ6B 3EPAA 3H0VB 3EPAB 1I7MB 1I7MA 1TMIA 3DZ4A 3DZ4B 3DZ2B 3DZ2A 3EP3A 3EP7A 3DZ5A 3EP3B 3EP7B 5TVOA 3DZ5B 3EP8A 5TVOB 1I72B 1I72A 1MHMB 1MHMA 3EP8B 3EP9B 3EP9A 3EP5B 1TLUA 3EP5A 1VR7A 1I7CA 3H0WA 1JENA 1JL0A 3H0VA 1I7CB 2IIIA 1JENB 3DZ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ7 B;  3EP4 B;  3H0W B;  3DZ3 B;  3EPB B;  1I7B B;  1I79 B;  3EP6 B;  3DZ6 B;  3EPA B;  1I7M B;  3DZ4 B;  3DZ2 B;  3EP3 B;  3EP7 B;  3DZ5 B;  5TVO B;  1I72 B;  1MHM B;  3EP8 B;  3EP9 B;  3EP5 B;  1I7C B;  1JEN B;  3H0V B; 
#chains in the Genus database with same CATH topology
 1VKN A;  1Q2X A;  4R3N A;  1GAD O;  2P2S A;  3RC7 A;  2CZC A;  1H9A A;  3E18 A;  1RYE A;  3PQV A;  3C8M A;  3OHS X;  4R5M A;  4MIN A;  1MHM B;  5BNT A;  4LSM A;  1IHX A;  2GZ3 A;  3H0W B;  3ING A;  2EJW A;  1DC4 A;  2X5K O;  3Q0E A;  3DZ3 B;  1T4B A;  1VSU A;  4R3W A;  3OQB A;  4R54 A;  4YWJ A;  3DZ6 B;  4PG8 A;  4QX6 A;  3F4L A;  1I7M B;  1QMH A;  3E6A A;  4Z0H O;  5A06 A;  2B4R O;  1E77 A;  4MKZ A;  4EW6 A;  5M6D A;  2PKQ P;  3HSK A;  4FB5 A;  3TZ6 A;  3GFG A;  5GZ1 A;  1YDW A;  1GPD G;  2GZ2 A;  3RC9 A;  3HNP A;  4MVJ D;  3L0D A;  4R51 A;  3PWS A;  3U3X A;  1CER A;  2VYV D;  2I5P O;  3QW2 A;  1RM4 A;  1YL5 A;  1EVJ A;  4R5H A;  3K2B A;  5T73 A;  3IWB B;  2I3A A;  1H6D A;  5JYF A;  3UW3 A;  1DBV O;  5A04 A;  1PQU A;  4K9D A;  4DPM A;  4MIO A;  4R4J A;  3DAP A;  2VYN D;  1TB4 A;  3MTJ A;  3FHL A;  1MC4 A;  3ABI A;  5C7I O;  1GL3 A;  2IXA A;  5GZ3 A;  3EP3 B;  2HJS A;  4PG7 A;  1P1F A;  4MKX A;  1QKI A;  1E7M A;  2DPG A;  1DC5 A;  3BTS A;  3JSA A;  1TLT A;  4N54 A;  1OFG A;  3NT2 A;  3EZY A;  4XB1 A;  4WNI A;  4XQ9 A;  4HKT A;  3GDO A;  3LC7 O;  2HKI A;  4R41 A;  3WYB A;  2AXQ A;  2DAP A;  1DAP A;  1QXS A;  1QMI A;  1EBF A;  4GPD 1;  1CRW G;  1E7Y A;  3NT4 A;  1XYG A;  2G17 A;  2OZP A;  4MVJ E;  2B4T O;  4IQ8 A;  3IJP A;  1I7B B;  4XB2 A;  2NVW A;  3DMT A;  4GMG A;  4DPL A;  3PYM A;  5EES A;  2GZ1 A;  1VM6 A;  3B1K A;  3WGY A;  4L9R A;  3EP8 B;  1NWH A;  1RM0 A;  1H6C A;  4WOJ A;  2H63 A;  1NVM B;  3GPD G;  1H94 A;  3H0V B;  4PG6 A;  1PR3 A;  3PZR A;  3EC7 A;  3LVF O;  1HDG O;  4O8J A;  3QY9 A;  2YYY A;  2Q49 A;  4GQA A;  1YWG O;  1DC3 A;  1NQO A;  3ZCX A;  2VYN A;  3Q2I A;  2PKR A;  1NQA O;  3V2U A;  1LA2 A;  1K3T A;  2GLX A;  3QVT A;  3B20 A;  1SZJ G;  4H3V A;  3RVD A;  1GAE O;  3M2T A;  3Q11 A;  1DRW A;  3IWC B;  2BH9 A;  1OZA A;  3RC2 A;  1DIH A;  2XF8 A;  3CPS A;  1GCU A;  3EP6 B;  1H9B A;  3DBV O;  4JN6 B;  5DDI P;  1XEA A;  1NPT O;  3V5N A;  1C3V A;  3TV1 A;  1MB4 A;  3WB9 A;  3NTQ A;  3EP5 B;  3BIO A;  3MOI A;  3OA2 A;  1U8F O;  5KVS A;  5JYE A;  2HO5 A;  4XQG A;  1H93 A;  5JY6 A;  3E9M A;  3O9Z A;  4RL6 A;  4IQ0 A;  1B7G O;  1F06 A;  3HXL A;  1YL6 A;  3WBF A;  3TW3 A;  3L4S O;  4LRT B;  1DRU A;  4PLP A;  1CF2 O;  3NTO A;  4DIB A;  1NQ5 A;  2QZ9 A;  2NQT A;  3IWD B;  1J0X O;  2EP5 A;  5JW6 A;  1I33 A;  3RCB A;  1VC2 A;  4XQE A;  3EPB B;  1JKI A;  2FPN A;  2R00 A;  3I23 A;  1VSV A;  1Q7G A;  1P9L A;  2O4U X;  3DB2 A;  3VOS A;  3QV1 A;  1PS8 A;  3L6O O;  1GYP A;  4AK1 A;  3VAZ A;  3EP9 B;  4LRS B;  3E5R A;  3DMT C;  5A03 A;  4MJL A;  1E5Q A;  3HQ4 O;  1P1J A;  3BTU A;  1S7C A;  3IP3 A;  3CEA A;  1YL7 A;  3QVS A;  4MIY A;  3PYX A;  3CIF A;  5GZ6 A;  1DSS G;  3UUW A;  4MVJ A;  3STH A;  3WGO A;  3DZ4 B;  1PQP A;  1DRV A;  2VYV A;  5KVQ A;  3LC1 O;  4XQC A;  3GNQ A;  1DC6 A;  2GD1 O;  1P1I A;  1A7K A;  1BRM A;  4MVJ P;  1H2H A;  1H6B A;  1VKO A;  4O89 A;  3K73 O;  1JKF A;  4II7 A;  1RYD A;  2BHL A;  1P1H A;  1PU2 A;  3K9Q O;  3MZ0 A;  2DUU A;  3WBB A;  4MVJ H;  1GR0 A;  1GD1 O;  3PWK A;  4O63 O;  4TVB A;  5J9G A;  4CLQ A;  3B1J A;  4F3Y A;  5EER A;  1YS4 A;  3KGD A;  4O59 O;  3EPA B;  5A05 A;  3V1Y A;  1FF9 A;  3PYL A;  3QVX A;  4YDR A;  3WGZ A;  5TVO B;  2D2I A;  1H6A A;  4NHE A;  2X0N A;  3H9E O;  3TUT A;  5C7L O;  3WYC A;  3WGQ A;  1ZNQ O;  2PKQ O;  1LC0 A;  4MIE A;  3CMC O;  3Q2K A;  5A02 A;  2O48 X;  3ZDF A;  1ML3 A;  1OBF O;  2DBV O;  3EP7 B;  3PFW O;  3CIN A;  3DZ5 B;  3E82 A;  5EIO A;  5CEF A;  1E5L A;  3ZJX A;  3FD8 A;  4XRG A;  4ZHS A;  2PH5 A;  1I7C B;  3KSD O;  4XR4 A;  3NT5 A;  1RM5 A;  4L8V A;  3DOC A;  3PZB A;  3RBV A;  1NWC A;  3EVN A;  4ZIC A;  5JYA A;  3E1K A;  1P1K A;  2YV3 A;  3KUX A;  2G82 A;  3DR3 A;  4HAD A;  2CVO A;  4MVJ F;  2POQ X;  3QVW A;  2R00 C;  5AQ1 A;  1LC3 A;  1I72 B;  5AVO A;  2DC1 A;  1RM3 A;  1T4D A;  4PG5 A;  3DZ7 B;  3IDS A;  1TVE A;  4DPK A;  1NX6 A;  4MVJ G;  1I32 A;  3KV3 O;  3HJA A;  4WNC A;  3DO5 A;  3RC1 A;  3C1A A;  1NBO A;  4INA A;  1EBU A;  4BOY A;  5EIN A;  2Q22 A;  2IXB A;  2X5J O;  4DBV O;  2I3G A;  1TA4 A;  3Q1L A;  3TUX A;  1JN0 A;  2Q4E A;  3EP4 B;  3KSZ O;  5C7O O;  2GYY A;  3DTY A;  3BTV A;  3EUW A;  1I79 B;  4LGV A;  1IHY A;  4P8R A;  2EP7 A;  3OA0 A;  3LC2 O;  4PG4 A;  3DZ2 B;  1UYJ A;  1ZH8 A;  4MVJ I;  1GYQ A;  4KOA A;  1J5P A;  1ARZ A;  3NTR A;  1DPG A;  4MVJ M;  1U1I A;  1JEN B;  4GMF A; 
#chains in the Genus database with same CATH homology
 3DZ7 B;  3EP4 A;  3EP4 B;  3H0W B;  3DZ3 B;  3DZ3 A;  3EPB A;  3EPB B;  1I7B A;  1I7B B;  1I79 A;  1I79 B;  1MSV A;  3DZ6 A;  3EP6 B;  3EP6 A;  3DZ6 B;  3EPA A;  3H0V B;  3EPA B;  1I7M B;  1I7M A;  1TMI A;  3DZ4 A;  3DZ4 B;  3DZ2 B;  3DZ2 A;  3EP3 A;  3EP7 A;  3DZ5 A;  3EP3 B;  3EP7 B;  5TVO A;  3DZ5 B;  3EP8 A;  5TVO B;  1I72 B;  1I72 A;  1MHM B;  1MHM A;  3EP8 B;  3EP9 B;  3EP9 A;  3EP5 B;  1TLU A;  3EP5 A;  1VR7 A;  1I7C A;  3H0W A;  1JEN A;  1JL0 A;  3H0V A;  1I7C B;  2III A;  1JEN B;  3DZ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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