1I7MB

Human s-adenosylmethionine decarboxylase with covalently bound pyruvoyl group and complexed with 4-amidinoindan-1-one-2'-amidinohydrazone
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
64
structure length
57
Chain Sequence
AHFFEGTEKLLEVWFSRGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN
total genus 8
structure length 57
sequence length 64
chains with identical sequence D
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2001-03-09
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.360.50 Alpha Beta 2-Layer Sandwich Dihydrodipicolinate Reductase; domain 2 S-adenosylmethionine decarboxylase 1i7mB01
1MHMB 1I7BB 3DZ6B 1I79B 3EP5B 3DZ5B 3DZ2B 3EP8B 3DZ4B 3EPAB 3EP7B 3EP6B 1I7MB 3DZ3B 3EP4B 1I7CB 5TVOB 3EP3B 3H0WB 3EPBB 3H0VB 1JENB 3DZ7B 3EP9B 1I72B
chains in the Genus database with same CATH superfamily
2AXQA 3CIFA 2GLXA 3TUTA 1HDGO 4XB1A 1LA2A 1EVJA 1NBOA 1H6AA 1YL7A 1P1IA 3PZRA 1GAEO 4O8JA 3K73O 4HADA 4R3NA 4XB2A 1YWGO 4FB5A 1ML3A 3PWKA 3OA2A 1U1IA 2VYNA 4PLPA 1I32A 1NVMB 3BTVA 2EJWA 3DOCA 2R00A 4YDRA 2VYVA 4MINA 1VKNA 4WNCA 4XQ9A 3CPSA 4GMGA 4AK1A 1Q7GA 3B1KA 1XEAA 4MVJI 3VOSA 3E9MA 3WB9A 3Q2IA 3DZ2B 2GZ3A 1PQPA 4LRSB 1DRWA 1A7KA 3ZJXA 4QX6A 2NVWA 3NT4A 3EZYA 4N54A 3OHSX 4DPMA 3WBFA 1U8FO 5A05A 1Q2XA 1C3VA 3QW2A 4MIOA 3NTRA 2YYYA 1BRMA 3FHLA 1OBFO 3GFGA 3PYMA 1CERA 1GR0A 1VC2A 1RM5A 1XYGA 4L8VA 3BTSA 2QZ9A 3DZ4B 3EC7A 1H2HA 3IWBB 4ZICA 3QVWA 4XQGA 3E82A 4MVJP 3E6AA 3RC9A 2CVOA 3TV1A 3L0DA 1NWHA 2B4RO 1DRVA 1EBFA 1H9BA 3I23A 4P8RA 3NTQA 2HKIA 3STHA 4DBVO 3BIOA 2G82A 3MZ0A 5C7OO 1PQUA 1P1JA 3RVDA 3V1YA 3WGYA 1NPTO 1MC4A 3DO5A 1E7YA 2HO5A 1P1KA 3MTJA 4YWJA 2O48X 4R3WA 1GL3A 3FD8A 4R5HA 1H9AA 1DC3A 3DAPA 4GMFA 1H94A 1PU2A 1YS4A 1DBVO 3LC2O 3RC1A 5JY6A 3EPAB 3BTUA 1GPDG 3OQBA 2YV3A 3IP3A 1GD1O 3H0VB 3CMCO 3E5RA 3IDSA 5AVOA 4IQ8A 2X5JO 1I72B 3RBVA 3U3XA 3PFWO 1QMIA 3Q2KA 5C7LO 3RC7A 2GZ2A 3IJPA 4MVJE 3DMTC 4PG7A 2EP7A 5JYAA 2OZPA 2CZCA 5EESA 1B7GO 1J0XO 1DSSG 3EUWA 1I7MB 3GDOA 4GQAA 3KSZO 4HKTA 4XR4A 3RC2A 4MIYA 4R5MA 1RYEA 4DPKA 3C1AA 2X5KO 3QY9A 2P2SA 2PKQP 4XQCA 1YL6A 3LVFO 3Q1LA 1JKFA 3PWSA 1NQAO 1DC4A 4JN6B 2D2IA 3E1KA 1PR3A 4H3VA 3EP3B 3EPBB 3WYBA 1LC3A 5DDIP 1TB4A 4XQEA 1I33A 3PQVA 3WYCA 3MOIA 4INAA 1P1HA 5JW6A 2GYYA 3NTOA 1VKOA 1RM4A 3UUWA 3EP8B 3B1JA 3PZBA 4K9DA 3KSDO 1CRWG 1IHXA 2BHLA 3DZ3B 4EW6A 2HJSA 5TVOB 2I3AA 1NWCA 4XRGA 4II7A 1QMHA 5JYFA 2PH5A 3PYXA 4KOAA 4LGVA 1LC0A 3LC7O 5A03A 4MVJH 5BNTA 2X0NA 1E5QA 4LSMA 3Q0EA 1CF2O 3C8MA 3E18A 3HSKA 4L9RA 1ZH8A 1JN0A 5J9GA 2H63A 3KV3O 1I7CB 2O4UX 3RCBA 2GZ1A 1T4DA 4BOYA 3Q11A 4WOJA 1GCUA 2IXBA 4MVJD 4MJLA 4DPLA 1QKIA 1I79B 1TA4A 1IHYA 1DC5A 2EP5A 4R41A 4F3YA 4ZHSA 1E77A 2FPNA 5A02A 5AQ1A 2PKQO 1RYDA 3LC1O 4MVJF 4WNIA 1VSVA 4PG6A 4MVJM 3GPDG 1OFGA 1DC6A 1YDWA 3HJAA 2PKRA 2DUUA 1J5PA 3EP9B 4O63O 5KVQA 1P1FA 1RM3A 5A06A 3EP7B 3QVSA 5T73A 1H6DA 3EVNA 3DMTA 4MVJA 3INGA 2G17A 3K9QO 3KGDA 2R00C 3OA0A 4GPD1 1PS8A 3EP5B 3NT2A 2Q4EA 3HNPA 4PG8A 3VAZA 1RM0A 3IWDB 3EP6B 3L4SO 2IXAA 4PG5A 4O89A 1P9LA 3NT5A 5C7IO 3PYLA 3WGOA 1UYJA 4IQ0A 4MIEA 3L6OO 1NX6A 1MB4A 4DIBA 3H0WB 1JENB 5JYEA 3ABIA 2B4TO 1DPGA 1H93A 3K2BA 3HQ4O 1I7BB 1NQ5A 1EBUA 2DAPA 3DZ6B 3M2TA 3WGZA 3DZ5B 1JKIA 4R4JA 2DPGA 4O59O 3JSAA 5KVSA 1FF9A 1T4BA 4RL6A 4Z0HO 3DR3A 3EP4B 3ZDFA 5GZ6A 4R54A 1H6CA 1H6BA 2GD1O 3CEAA 2XF8A 3CINA 1S7CA 1GYPA 3QV1A 5EERA 3B20A 3DZ7B 1E7MA 3V2UA 1SZJG 1NQOA 3UW3A 1DIHA 1E5LA 4NHEA 3TW3A 2BH9A 4MKZA 4TVBA 1VM6A 1GYQA 1DRUA 3F4LA 1VSUA 5A04A 2Q49A 2I3GA 4R51A 3H9EO 3V5NA 1F06A 3GNQA 2I5PO 1TVEA 1YL5A 1ZNQO 2DBVO 5EINA 2POQX 1OZAA 4LRTB 4CLQA 3O9ZA 3DB2A 1MHMB 4PG4A 4MVJG 3ZCXA 3TZ6A 5EIOA 3DBVO 2DC1A 3KUXA 2VYND 1QXSA 3WGQA 1TLTA 3WBBA 3IWCB 1DAPA 3HXLA 3TUXA 5CEFA 2Q22A 2VYVD 1ARZA 5GZ3A 3DTYA 5M6DA 3QVXA 2NQTA 3QVTA 1GADO 4MKXA 5GZ1A 1K3TA
chains in the Genus database with same CATH topology
1MHMB 3DZ7A 1I72A 1I7BB 1MHMA 1TMIA 3EP9A 3DZ6B 1I7BA 1I79B 3EP5B 1I79A 3DZ6A 3DZ5B 3EP5A 3DZ2B 3DZ5A 1MSVA 3EP8B 3DZ4B 3EPAB 3EP7B 3DZ2A 3EP8A 3EP6B 3DZ4A 3EPAA 3EP7A 1I7MB 3EP6A 3DZ3B 3EP4B 1I7CB 1TLUA 5TVOB 2IIIA 1I7MA 3EP4A 1I7CA 5TVOA 3DZ3A 3EP3B 3H0WB 3EPBB 3H0VB 1VR7A 3EP3A 1JENB 3H0WA 3EPBA 3H0VA 1JENA 3DZ7B 3EP9B 1I72B 1JL0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MHM B;  1I7B B;  3DZ6 B;  1I79 B;  3EP5 B;  3DZ5 B;  3DZ2 B;  3EP8 B;  3DZ4 B;  3EPA B;  3EP7 B;  3EP6 B;  1I7M B;  3DZ3 B;  3EP4 B;  1I7C B;  5TVO B;  3EP3 B;  3H0W B;  3EPB B;  3H0V B;  1JEN B;  3DZ7 B;  3EP9 B;  1I72 B; 
#chains in the Genus database with same CATH topology
 2AXQ A;  3CIF A;  2GLX A;  3TUT A;  1HDG O;  4XB1 A;  1LA2 A;  1EVJ A;  1NBO A;  1H6A A;  1YL7 A;  1P1I A;  3PZR A;  1GAE O;  4O8J A;  3K73 O;  4HAD A;  4R3N A;  4XB2 A;  1YWG O;  4FB5 A;  1ML3 A;  3PWK A;  3OA2 A;  1U1I A;  2VYN A;  4PLP A;  1I32 A;  1NVM B;  3BTV A;  2EJW A;  3DOC A;  2R00 A;  4YDR A;  2VYV A;  4MIN A;  1VKN A;  4WNC A;  4XQ9 A;  3CPS A;  4GMG A;  4AK1 A;  1Q7G A;  3B1K A;  1XEA A;  4MVJ I;  3VOS A;  3E9M A;  3WB9 A;  3Q2I A;  3DZ2 B;  2GZ3 A;  1PQP A;  4LRS B;  1DRW A;  1A7K A;  3ZJX A;  4QX6 A;  2NVW A;  3NT4 A;  3EZY A;  4N54 A;  3OHS X;  4DPM A;  3WBF A;  1U8F O;  5A05 A;  1Q2X A;  1C3V A;  3QW2 A;  4MIO A;  3NTR A;  2YYY A;  1BRM A;  3FHL A;  1OBF O;  3GFG A;  3PYM A;  1CER A;  1GR0 A;  1VC2 A;  1RM5 A;  1XYG A;  4L8V A;  3BTS A;  2QZ9 A;  3DZ4 B;  3EC7 A;  1H2H A;  3IWB B;  4ZIC A;  3QVW A;  4XQG A;  3E82 A;  4MVJ P;  3E6A A;  3RC9 A;  2CVO A;  3TV1 A;  3L0D A;  1NWH A;  2B4R O;  1DRV A;  1EBF A;  1H9B A;  3I23 A;  4P8R A;  3NTQ A;  2HKI A;  3STH A;  4DBV O;  3BIO A;  2G82 A;  3MZ0 A;  5C7O O;  1PQU A;  1P1J A;  3RVD A;  3V1Y A;  3WGY A;  1NPT O;  1MC4 A;  3DO5 A;  1E7Y A;  2HO5 A;  1P1K A;  3MTJ A;  4YWJ A;  2O48 X;  4R3W A;  1GL3 A;  3FD8 A;  4R5H A;  1H9A A;  1DC3 A;  3DAP A;  4GMF A;  1H94 A;  1PU2 A;  1YS4 A;  1DBV O;  3LC2 O;  3RC1 A;  5JY6 A;  3EPA B;  3BTU A;  1GPD G;  3OQB A;  2YV3 A;  3IP3 A;  1GD1 O;  3H0V B;  3CMC O;  3E5R A;  3IDS A;  5AVO A;  4IQ8 A;  2X5J O;  1I72 B;  3RBV A;  3U3X A;  3PFW O;  1QMI A;  3Q2K A;  5C7L O;  3RC7 A;  2GZ2 A;  3IJP A;  4MVJ E;  3DMT C;  4PG7 A;  2EP7 A;  5JYA A;  2OZP A;  2CZC A;  5EES A;  1B7G O;  1J0X O;  1DSS G;  3EUW A;  1I7M B;  3GDO A;  4GQA A;  3KSZ O;  4HKT A;  4XR4 A;  3RC2 A;  4MIY A;  4R5M A;  1RYE A;  4DPK A;  3C1A A;  2X5K O;  3QY9 A;  2P2S A;  2PKQ P;  4XQC A;  1YL6 A;  3LVF O;  3Q1L A;  1JKF A;  3PWS A;  1NQA O;  1DC4 A;  4JN6 B;  2D2I A;  3E1K A;  1PR3 A;  4H3V A;  3EP3 B;  3EPB B;  3WYB A;  1LC3 A;  5DDI P;  1TB4 A;  4XQE A;  1I33 A;  3PQV A;  3WYC A;  3MOI A;  4INA A;  1P1H A;  5JW6 A;  2GYY A;  3NTO A;  1VKO A;  1RM4 A;  3UUW A;  3EP8 B;  3B1J A;  3PZB A;  4K9D A;  3KSD O;  1CRW G;  1IHX A;  2BHL A;  3DZ3 B;  4EW6 A;  2HJS A;  5TVO B;  2I3A A;  1NWC A;  4XRG A;  4II7 A;  1QMH A;  5JYF A;  2PH5 A;  3PYX A;  4KOA A;  4LGV A;  1LC0 A;  3LC7 O;  5A03 A;  4MVJ H;  5BNT A;  2X0N A;  1E5Q A;  4LSM A;  3Q0E A;  1CF2 O;  3C8M A;  3E18 A;  3HSK A;  4L9R A;  1ZH8 A;  1JN0 A;  5J9G A;  2H63 A;  3KV3 O;  1I7C B;  2O4U X;  3RCB A;  2GZ1 A;  1T4D A;  4BOY A;  3Q11 A;  4WOJ A;  1GCU A;  2IXB A;  4MVJ D;  4MJL A;  4DPL A;  1QKI A;  1I79 B;  1TA4 A;  1IHY A;  1DC5 A;  2EP5 A;  4R41 A;  4F3Y A;  4ZHS A;  1E77 A;  2FPN A;  5A02 A;  5AQ1 A;  2PKQ O;  1RYD A;  3LC1 O;  4MVJ F;  4WNI A;  1VSV A;  4PG6 A;  4MVJ M;  3GPD G;  1OFG A;  1DC6 A;  1YDW A;  3HJA A;  2PKR A;  2DUU A;  1J5P A;  3EP9 B;  4O63 O;  5KVQ A;  1P1F A;  1RM3 A;  5A06 A;  3EP7 B;  3QVS A;  5T73 A;  1H6D A;  3EVN A;  3DMT A;  4MVJ A;  3ING A;  2G17 A;  3K9Q O;  3KGD A;  2R00 C;  3OA0 A;  4GPD 1;  1PS8 A;  3EP5 B;  3NT2 A;  2Q4E A;  3HNP A;  4PG8 A;  3VAZ A;  1RM0 A;  3IWD B;  3EP6 B;  3L4S O;  2IXA A;  4PG5 A;  4O89 A;  1P9L A;  3NT5 A;  5C7I O;  3PYL A;  3WGO A;  1UYJ A;  4IQ0 A;  4MIE A;  3L6O O;  1NX6 A;  1MB4 A;  4DIB A;  3H0W B;  1JEN B;  5JYE A;  3ABI A;  2B4T O;  1DPG A;  1H93 A;  3K2B A;  3HQ4 O;  1I7B B;  1NQ5 A;  1EBU A;  2DAP A;  3DZ6 B;  3M2T A;  3WGZ A;  3DZ5 B;  1JKI A;  4R4J A;  2DPG A;  4O59 O;  3JSA A;  5KVS A;  1FF9 A;  1T4B A;  4RL6 A;  4Z0H O;  3DR3 A;  3EP4 B;  3ZDF A;  5GZ6 A;  4R54 A;  1H6C A;  1H6B A;  2GD1 O;  3CEA A;  2XF8 A;  3CIN A;  1S7C A;  1GYP A;  3QV1 A;  5EER A;  3B20 A;  3DZ7 B;  1E7M A;  3V2U A;  1SZJ G;  1NQO A;  3UW3 A;  1DIH A;  1E5L A;  4NHE A;  3TW3 A;  2BH9 A;  4MKZ A;  4TVB A;  1VM6 A;  1GYQ A;  1DRU A;  3F4L A;  1VSU A;  5A04 A;  2Q49 A;  2I3G A;  4R51 A;  3H9E O;  3V5N A;  1F06 A;  3GNQ A;  2I5P O;  1TVE A;  1YL5 A;  1ZNQ O;  2DBV O;  5EIN A;  2POQ X;  1OZA A;  4LRT B;  4CLQ A;  3O9Z A;  3DB2 A;  1MHM B;  4PG4 A;  4MVJ G;  3ZCX A;  3TZ6 A;  5EIO A;  3DBV O;  2DC1 A;  3KUX A;  2VYN D;  1QXS A;  3WGQ A;  1TLT A;  3WBB A;  3IWC B;  1DAP A;  3HXL A;  3TUX A;  5CEF A;  2Q22 A;  2VYV D;  1ARZ A;  5GZ3 A;  3DTY A;  5M6D A;  3QVX A;  2NQT A;  3QVT A;  1GAD O;  4MKX A;  5GZ1 A;  1K3T A; 
#chains in the Genus database with same CATH homology
 1MHM B;  3DZ7 A;  1I72 A;  1I7B B;  1MHM A;  1TMI A;  3EP9 A;  3DZ6 B;  1I7B A;  1I79 B;  3EP5 B;  1I79 A;  3DZ6 A;  3DZ5 B;  3EP5 A;  3DZ2 B;  3DZ5 A;  1MSV A;  3EP8 B;  3DZ4 B;  3EPA B;  3EP7 B;  3DZ2 A;  3EP8 A;  3EP6 B;  3DZ4 A;  3EPA A;  3EP7 A;  1I7M B;  3EP6 A;  3DZ3 B;  3EP4 B;  1I7C B;  1TLU A;  5TVO B;  2III A;  1I7M A;  3EP4 A;  1I7C A;  5TVO A;  3DZ3 A;  3EP3 B;  3H0W B;  3EPB B;  3H0V B;  1VR7 A;  3EP3 A;  1JEN B;  3H0W A;  3EPB A;  3H0V A;  1JEN A;  3DZ7 B;  3EP9 B;  1I72 B;  1JL0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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