The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
126
|
sequence length |
513
|
structure length |
474
|
Chain Sequence |
LRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCFLLDFEEDLKALHSVQCSP
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
pubmed doi rcsb |
| molecule tags |
Signaling protein
|
| source organism |
Homo sapiens
|
| molecule keywords |
LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5
|
| total genus |
126
|
| structure length |
474
|
| sequence length |
513
|
| chains with identical sequence |
B, E, F
|
| ec nomenclature | |
| pdb deposition date | 2013-06-11 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01462 | LRRNT | Leucine rich repeat N-terminal domain |
| A | PF13855 | LRR_8 | Leucine rich repeat |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Alpha-Beta Horseshoe | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | Ribonuclease Inhibitor |
#chains in the Genus database with same CATH superfamily 3E3Z A; 4LXS A; 3ZYN A; 4WP6 A; 1JL5 A; 4WYK A; 3M18 A; 5IJD A; 4RWT C; 4RCW A; 4PSJ A; 2XWT C; 2Z82 A; 3DZE A; 5AWA A; 5GS2 B; 3RGX A; 1H6U A; 2P1N B; 3W3K A; 4C2A B; 1K5D C; 2Z66 A; 4FMZ A; 2JE1 A; 3OJA B; 1P9A G; 4IM6 A; 4FDW A; 2OMU A; 3WPD A; 5CMN A; 3E2J A; 2OMY A; 4R6A A; 1XEU A; 4ECO A; 2BNH A; 5AZ5 A; 2R9U A; 2Z64 A; 3O53 A; 4FS7 A; 4P8S A; 4LI2 A; 3BZ5 A; 4P91 A; 2FT3 A; 5D3I A; 1M9S A; 3ULV A; 3W3N A; 2P1Q B; 3CIY A; 4R58 A; 5IJB A; 4Z79 A; 4QXE A; 1P8T A; 1FQV A; 2O6S A; 1XEC A; 2WQV A; 2P1M B; 4FHO A; 4LSA A; 1KOO A; 4MN8 B; 3RFE A; 4PEQ B; 2OMT A; 4KXF B; 1KOH A; 3CVR A; 5IYX C; 4L3A A; 1P8V A; 4R5D A; 4ECN A; 3P72 A; 3G39 A; 3WPH A; 4M7E C; 4BSR A; 1G9U A; 2OMX A; 2O6Q A; 1WWL A; 4MQW X; 4Z94 G; 3FXI A; 4M7E A; 1DFJ I; 1O6T A; 4G8A A; 3OGM B; 4UFR A; 3RIZ A; 3G04 C; 3W3M A; 4U08 A; 4AW4 A; 1LTX A; 3E6J A; 1M9L A; 1W8A A; 3G3B A; 5GMF A; 1A4Y A; 3REZ A; 4R07 A; 4V2D A; 4XSQ A; 4QC0 A; 2Z63 A; 4J4L A; 4U7L A; 4Z64 C; 3ULU A; 3C6O B; 1YRG A; 3WPC A; 4FCG A; 4CC4 C; 4QBZ A; 4I6J B; 4CIL A; 4U09 A; 3ZYO A; 2Z62 A; 1OTM A; 4CC4 A; 2OMW A; 3G06 A; 4TZH A; 3ZYI A; 4Y61 B; 1O6V A; 4KT1 A; 3WPI A; 4LSC A; 4EZG A; 3JB9 j; 4YEB B; 1OTN A; 3OGK B; 5HZL B; 1OGQ A; 2V9T B; 3KJ4 A; 3W3L A; 4PKI G; 2UZY A; 4CNC A; 2ASS B; 2JQD A; 4FD0 A; 5A5C A; 4XOS A; 4K17 A; 4RCA B; 2ID5 A; 2WQW A; 2RA8 A; 4BSU A; 4NKG A; 5LFN A; 4V2E A; 1FO1 A; 4AY9 X; 4R5C A; 3VQ1 A; 3RFJ A; 4NKH A; 3A79 B; 5GS0 A; 1SQ0 B; 3SB4 A; 4U06 A; 4CP6 A; 2V70 A; 3RW7 A; 3ULA A; 4BSS A; 2AST B; 5CMP A; 3WPE A; 2O6R A; 1FT8 A; 2Q4G W; 1M10 B; 4R0A A; 5B0N A; 3WPF A; 5GMG A; 2UZX A; 2Z65 A; 3G3A A; 5AWB A; 5B4P A; 2OMZ A; 4LSX C; 3C6P B; 1U0N D; 1OTO A; 3UL7 A; 1D0B A; 1XKU A; 3CIG A; 3WPG A; 3O6N A; 2V9S A; 4ARR A; 4LSX A; 4PER A; 5FTT B; 5GMH A; 4PQ8 A; 2Y5Q A; 4Q3I A; 4ARN A; 4GT6 A; 2XOT A; 1O6S A; 4R6G A; 1ZIW A; 1Z7X W; 4LI1 A; 1GWB A; 4L3F A; 4C2B B; 1QYY A; 3W3G A; 1M0Z A; 3C6N B; 4R08 A; 3RJ0 A; 3GOZ A; 4V2C A; 2Z7X A; 4OQT A; 4R09 A; 4GLP A; 4HQ1 A; 5IJC A; 3UN9 A; 3UL9 A; 4H09 A; 2Z81 A; 4R6J A; 4J0M A; 3RFS A; 4Z61 C; 5HDH A; 2P1O B; 3RGZ A; 2OMV A; 2WFH A; 4R6F A; 4XGO A; 1H6T A; 1XWD C; 4Q3G A; 4B8C D; 4CNM A; 2BEX A; 3VQ2 A; 3UL8 A; 3ZYJ A; 3E4G A; 2RR6 A; 1OZN A; 1PGV A; 2P1P B; 3RW6 A; 2IFG A; 3PMH G; 2JE0 A; 2Z7X B; 1DS9 A; 2A0Z A; 3W3J A; 1A9N A; 5GQR K; 3WN4 A; 3WPB A; 3TSR E; 1IO0 A; 1XCD A; 2ELL A; 1FS2 A; 4BV4 R; 3OGL B; 2WQU A; 4Z8G A; 1OOK G; 2CA6 A; 3OJA A; 1K5G C; 1DCE A; 3M19 A; 5AWD A; 5AWC A; 4LXR A; 5B0T A; 2WQX A; 4KNG A; 4Q62 A; #chains in the Genus database with same CATH topology 3E3Z A; 4LXS A; 3ZYN A; 4WP6 A; 1JL5 A; 4WYK A; 3M18 A; 5IJD A; 4RWT C; 4RCW A; 4PSJ A; 2XWT C; 2Z82 A; 3DZE A; 5AWA A; 5GS2 B; 3RGX A; 1H6U A; 2P1N B; 3W3K A; 4C2A B; 1K5D C; 2Z66 A; 4FMZ A; 2JE1 A; 3OJA B; 1P9A G; 4IM6 A; 4FDW A; 2OMU A; 3WPD A; 5CMN A; 3E2J A; 2OMY A; 4R6A A; 1XEU A; 4ECO A; 2BNH A; 5AZ5 A; 2R9U A; 2Z64 A; 3O53 A; 4FS7 A; 4P8S A; 4LI2 A; 3BZ5 A; 4P91 A; 2FT3 A; 5D3I A; 1M9S A; 3ULV A; 3W3N A; 2P1Q B; 3CIY A; 4R58 A; 5IJB A; 4Z79 A; 4QXE A; 1P8T A; 1FQV A; 2O6S A; 1XEC A; 2WQV A; 2P1M B; 4FHO A; 4LSA A; 1KOO A; 4MN8 B; 3RFE A; 4PEQ B; 2OMT A; 4KXF B; 1KOH A; 3CVR A; 5IYX C; 4L3A A; 1P8V A; 4R5D A; 4ECN A; 3P72 A; 3G39 A; 3WPH A; 4M7E C; 4BSR A; 1G9U A; 2OMX A; 2O6Q A; 1WWL A; 4MQW X; 4Z94 G; 3FXI A; 4M7E A; 1DFJ I; 1O6T A; 4G8A A; 3OGM B; 4UFR A; 3RIZ A; 3G04 C; 3W3M A; 4U08 A; 4AW4 A; 1LTX A; 3E6J A; 1M9L A; 1W8A A; 3G3B A; 5GMF A; 1A4Y A; 3REZ A; 4R07 A; 4V2D A; 4XSQ A; 4QC0 A; 2Z63 A; 4J4L A; 4U7L A; 4Z64 C; 3ULU A; 3C6O B; 1YRG A; 3WPC A; 4FCG A; 4CC4 C; 4QBZ A; 4I6J B; 4CIL A; 4U09 A; 3ZYO A; 2Z62 A; 1OTM A; 4CC4 A; 2OMW A; 3G06 A; 4TZH A; 3ZYI A; 4Y61 B; 1O6V A; 4KT1 A; 3WPI A; 4LSC A; 4EZG A; 3JB9 j; 4YEB B; 1OTN A; 3OGK B; 5HZL B; 1OGQ A; 2V9T B; 3KJ4 A; 3W3L A; 4PKI G; 2UZY A; 4CNC A; 2ASS B; 2JQD A; 4FD0 A; 5A5C A; 4XOS A; 4K17 A; 4RCA B; 2ID5 A; 2WQW A; 2RA8 A; 4BSU A; 4NKG A; 5LFN A; 4V2E A; 1FO1 A; 4AY9 X; 4R5C A; 3VQ1 A; 3RFJ A; 4NKH A; 3A79 B; 5GS0 A; 1SQ0 B; 3SB4 A; 4U06 A; 4CP6 A; 2V70 A; 3RW7 A; 3ULA A; 4BSS A; 2AST B; 5CMP A; 3WPE A; 2O6R A; 1FT8 A; 2Q4G W; 1M10 B; 4R0A A; 5B0N A; 3WPF A; 5GMG A; 2UZX A; 2Z65 A; 3G3A A; 5AWB A; 5B4P A; 2OMZ A; 4LSX C; 3C6P B; 1U0N D; 1OTO A; 3UL7 A; 1D0B A; 1XKU A; 3CIG A; 3WPG A; 3O6N A; 2V9S A; 4ARR A; 4LSX A; 4PER A; 5FTT B; 5GMH A; 4PQ8 A; 2Y5Q A; 4Q3I A; 4ARN A; 4GT6 A; 2XOT A; 1O6S A; 4R6G A; 1ZIW A; 1Z7X W; 4LI1 A; 1GWB A; 4L3F A; 4C2B B; 1QYY A; 3W3G A; 1M0Z A; 3C6N B; 4R08 A; 3RJ0 A; 3GOZ A; 4V2C A; 2Z7X A; 4OQT A; 4R09 A; 4GLP A; 4HQ1 A; 5IJC A; 3UN9 A; 4NZR M; 3UL9 A; 4H09 A; 2Z81 A; 4R6J A; 4J0M A; 3RFS A; 4Z61 C; 5HDH A; 2P1O B; 3RGZ A; 2OMV A; 2WFH A; 4R6F A; 4XGO A; 1H6T A; 1XWD C; 4Q3G A; 4B8C D; 4CNM A; 2BEX A; 3VQ2 A; 3UL8 A; 4NZT M; 3ZYJ A; 3E4G A; 2RR6 A; 1OZN A; 1PGV A; 2P1P B; 3RW6 A; 2IFG A; 3PMH G; 2JE0 A; 2Z7X B; 1DS9 A; 2A0Z A; 3W3J A; 1A9N A; 5GQR K; 3WN4 A; 3WPB A; 3TSR E; 1IO0 A; 1XCD A; 2ELL A; 1FS2 A; 4BV4 R; 3OGL B; 2WQU A; 4Z8G A; 1OOK G; 2CA6 A; 3OJA A; 1K5G C; 1DCE A; 3M19 A; 5AWD A; 5AWC A; 4LXR A; 5B0T A; 2WQX A; 4KNG A; 4Q62 A; #chains in the Genus database with same CATH homology 3E3Z A; 4LXS A; 3ZYN A; 4WP6 A; 1JL5 A; 4WYK A; 3M18 A; 5IJD A; 4RWT C; 4RCW A; 4PSJ A; 2XWT C; 2Z82 A; 3DZE A; 5AWA A; 5GS2 B; 3RGX A; 1H6U A; 2P1N B; 3W3K A; 4C2A B; 1K5D C; 2Z66 A; 4FMZ A; 2JE1 A; 3OJA B; 1P9A G; 4IM6 A; 4FDW A; 2OMU A; 3WPD A; 5CMN A; 3E2J A; 2OMY A; 4R6A A; 1XEU A; 4ECO A; 2BNH A; 5AZ5 A; 2R9U A; 2Z64 A; 3O53 A; 4FS7 A; 4P8S A; 4LI2 A; 3BZ5 A; 4P91 A; 2FT3 A; 5D3I A; 1M9S A; 3ULV A; 3W3N A; 2P1Q B; 3CIY A; 4R58 A; 5IJB A; 4Z79 A; 4QXE A; 1P8T A; 1FQV A; 2O6S A; 1XEC A; 2WQV A; 2P1M B; 4FHO A; 4LSA A; 1KOO A; 4MN8 B; 3RFE A; 4PEQ B; 2OMT A; 4KXF B; 1KOH A; 3CVR A; 5IYX C; 4L3A A; 1P8V A; 4R5D A; 4ECN A; 3P72 A; 3G39 A; 3WPH A; 4M7E C; 4BSR A; 1G9U A; 2OMX A; 2O6Q A; 1WWL A; 4MQW X; 4Z94 G; 3FXI A; 4M7E A; 1DFJ I; 1O6T A; 4G8A A; 3OGM B; 4UFR A; 3RIZ A; 3G04 C; 3W3M A; 4U08 A; 4AW4 A; 1LTX A; 3E6J A; 1M9L A; 1W8A A; 3G3B A; 5GMF A; 1A4Y A; 3REZ A; 4R07 A; 4V2D A; 4XSQ A; 4QC0 A; 2Z63 A; 4J4L A; 4U7L A; 4Z64 C; 3ULU A; 3C6O B; 1YRG A; 3WPC A; 4FCG A; 4CC4 C; 4QBZ A; 4I6J B; 4CIL A; 4U09 A; 3ZYO A; 2Z62 A; 1OTM A; 4CC4 A; 2OMW A; 3G06 A; 4TZH A; 3ZYI A; 4Y61 B; 1O6V A; 4KT1 A; 3WPI A; 4LSC A; 4EZG A; 3JB9 j; 4YEB B; 1OTN A; 3OGK B; 5HZL B; 1OGQ A; 2V9T B; 3KJ4 A; 3W3L A; 4PKI G; 2UZY A; 4CNC A; 2ASS B; 2JQD A; 4FD0 A; 5A5C A; 4XOS A; 4K17 A; 4RCA B; 2ID5 A; 2WQW A; 2RA8 A; 4BSU A; 4NKG A; 5LFN A; 4V2E A; 1FO1 A; 4AY9 X; 4R5C A; 3VQ1 A; 3RFJ A; 4NKH A; 3A79 B; 5GS0 A; 1SQ0 B; 3SB4 A; 4U06 A; 4CP6 A; 2V70 A; 3RW7 A; 3ULA A; 4BSS A; 2AST B; 5CMP A; 3WPE A; 2O6R A; 1FT8 A; 2Q4G W; 1M10 B; 4R0A A; 5B0N A; 3WPF A; 5GMG A; 2UZX A; 2Z65 A; 3G3A A; 5AWB A; 5B4P A; 2OMZ A; 4LSX C; 3C6P B; 1U0N D; 1OTO A; 3UL7 A; 1D0B A; 1XKU A; 3CIG A; 3WPG A; 3O6N A; 2V9S A; 4ARR A; 4LSX A; 4PER A; 5FTT B; 5GMH A; 4PQ8 A; 2Y5Q A; 4Q3I A; 4ARN A; 4GT6 A; 2XOT A; 1O6S A; 4R6G A; 1ZIW A; 1Z7X W; 4LI1 A; 1GWB A; 4L3F A; 4C2B B; 1QYY A; 3W3G A; 1M0Z A; 3C6N B; 4R08 A; 3RJ0 A; 3GOZ A; 4V2C A; 2Z7X A; 4OQT A; 4R09 A; 4GLP A; 4HQ1 A; 5IJC A; 3UN9 A; 3UL9 A; 4H09 A; 2Z81 A; 4R6J A; 4J0M A; 3RFS A; 4Z61 C; 5HDH A; 2P1O B; 3RGZ A; 2OMV A; 2WFH A; 4R6F A; 4XGO A; 1H6T A; 1XWD C; 4Q3G A; 4B8C D; 4CNM A; 2BEX A; 3VQ2 A; 3UL8 A; 3ZYJ A; 3E4G A; 2RR6 A; 1OZN A; 1PGV A; 2P1P B; 3RW6 A; 2IFG A; 3PMH G; 2JE0 A; 2Z7X B; 1DS9 A; 2A0Z A; 3W3J A; 1A9N A; 5GQR K; 3WN4 A; 3WPB A; 3TSR E; 1IO0 A; 1XCD A; 2ELL A; 1FS2 A; 4BV4 R; 3OGL B; 2WQU A; 4Z8G A; 1OOK G; 2CA6 A; 3OJA A; 1K5G C; 1DCE A; 3M19 A; 5AWD A; 5AWC A; 4LXR A; 5B0T A; 2WQX A; 4KNG A; 4Q62 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
