1IS0A

Crystal structure of a complex of the src sh2 domain with conformationally constrained peptide inhibitor
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
102
structure length
102
Chain Sequence
EEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding.
pubmed doi rcsb
molecule tags Transferase/transferase inhibitor
source organism Rous sarcoma virus
molecule keywords Tyrosine-protein kinase transforming protein SRC
total genus 27
structure length 102
sequence length 102
chains with identical sequence B
ec nomenclature ec 2.7.10.2: Non-specific protein-tyrosine kinase.
pdb deposition date 2001-11-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 1is0A00
4OHLA 1QG1E 1O44A 3UYOA 3VGOA 1BG1A 1O4LA 3OP0A 1CJ1A 3QWYA 3PSJA 4XZ1A 1NRVA 1O48A 2LQNA 2CS0A 1Y1UA 1BHHA 3MXYA 3VRPA 2AOBA 3OB2B 5GJHA 4NWGA 3M7FA 1LKKA 2JYQA 2H8HA 1MILA 2GE9A 1O4GA 1RJAA 3GQIB 1F1WA 1MW4A 2CRHA 2DVJA 1BHFA 4K45A 1R1SA 4K11A 1TCEA 1BFIA 1KC2A 1M61A 1BFJA 1SHAA 1FBVA 1AB2A 1KSWA 2EO3A 3PJPA 3S8LA 1A07A 2L3TA 2IZVA 2ABLA 3VS3A 2IUGA 4EY0A 1M27A 2EYZA 1XA6A 2L6KA 2QMSA 3S8NA 1R1QA 1AOUF 1A1EA 1CSZA 1A1CA 4GL9E 1KA6A 2CR4A 3US4A 5EEQA 5HKZA 4M4ZA 2HCKA 3VS7A 2SRCA 5IBSA 1SKJA 3S9KA 1O4KA 2EKXA 4GPLB 1Y57A 5KAZA 1QADA 2CIAA 4A4CA 2K7AB 3VRZA 5DF6A 4F59A 3VS6A 2CI8A 1GRIA 1B47A 2DLYA 1FMKA 2PLEA 1O4NA 2FCIA 2MRKA 1AOTF 1F2FA 4P9ZA 3TL0A 1BKMA 3VS2A 1O45A 2SHPA 2GSBA 1O4FA 5HKWA 4FBNA 1LUIA 3VS4A 2MK2A 4E68A 1JYRA 3IMJA 2EO6A 1RQQC 1O4EA 1LCJA 2LCTA 2YSXA 2MC1A 3VS5A 4K2RA 4K44A 1X0NA 1IS0A 3N8MA 2PNAA 1AD5A 3PS5A 1FBZA 3HIZB 1OO4A 4U1PA 1IJRA 1A1AA 1A08A 3ZNIA 4D8KA 1AYDA 2HMHA 1OPLA 4QSYA 2HDXA 3GXXA 4H34A 1O4CA 2CBLA 1A09A 4U17A 1BHHB 3BUMB 3C7IA 2ETZA 3CXLA 3BUWB 1ZFPE 5AULA 1CWEA 3OVEA 1A1BA 2PNBA 2LNWA 2FO0A 1BM2A 1AYAA 3EAZA 1HCTB 2H46E 2XP1A 1O42A 4OHEA 2EL8A 4P9VA 1SPRA 4E93A 3CD3A 2RMXA 1O49A 1O4RA 1O47A 1K9AA 2L4KA 1SPSA 2DLZA 4JGHA 3HCKA 3VRYA 5DC4A 1I3ZA 1RPYA 1OO3A 1FYRA 5EELA 4GWFA 1BKLA 1O4QA 5EHPA 3CBLA 5J3XA 3CWGA 1O4OA 1LCKA 2OQ1A 1BLKA 3VROA 2CI9A 5D0JA 2C0IA 3HHMB 2DCRA 1O4JA 4OHIA 2MQIA 2RVFA 3GXWA 1LUMA 3PLFB 4LUEA 2Y3AB 3VS0A 1JYUA 1G83A 2Y1NA 5AXIA 2B3OA 2DM0A 2AUGA 1BF5A 1FU6A 5EG3B 4X6SA 4F5BA 1BMBA 2IUIA 2BBUA 2KNOA 1TZEE 1X27A 4OHDA 1O41A 1NZVA 2C9WA 4F5AA 3KFJA 1SHDA 2HUWA 5IBMA 1SHBA 3VRNA 2C0TA 1NZLA 5I6VA 4EIHA 1JWOA 1LUKA 3VS1A 1O43A 2LNXA 3IN7A 1A81A 3QWXX 1R1PA 3BKBA 2EU0A 2YU7A 3PQZA 3MXCA 1LKLA 1D4TA 2DX0A 1D4WA 3IMDA 1JU5A 1QCFA 1O4HA 4XZ0A 1UUSA 3PFVA 3PSKA 2AOAA 3N84A 3TKZA 3VRRA 1O4BA 1O4AA 4WWQA 1AYBA 3VRQA 5EHRA 3IN8A 1P13A 3UF4A 3BUXB 2PTKA 4DGXA 1CSYA 2VIFA 1PICA 1HCSB 1O4IA 3BUNB 1WQUA 5HKYA 5DC0B 1FU5A 1UURA 3MAZA 3OB1B 2HDVA 2OZOA 4LUDA 1O46A 4OHHA 5BO4A 4DGPA 3EACA 4A4BA 1YVHA 1X6CA 1YVLA 4H1OA 1OPKA 1KA7A 1O4PA 1Z3KA 5GJIA 2MRJA 1LUNA 2LQWA 4JE4A 1O4MA 2RSYA 2Y1MA 4JEGA 4FL2A 3WA4A 1O4DA 1CWDL 3OV1A 4L1BB 3K2MA 3BUOB 1BLJA 2K79B 5CDWA 5DC9A 1H9OA 3S8OA 2KK6A 2PLDA 3NHNA 2IUHA 4FL3A 4NWFA 1D1ZA 1GHUA 2C0OA 2EOBA 2ECDA 2EYVA 2EYYA 1JYQA 3T04A 1AYCA 1FHSA 4TZIA 2H5KA 4ROJA 2RORA 3N7YA
chains in the Genus database with same CATH superfamily
4OHLA 1QG1E 1O44A 3UYOA 3VGOA 1BG1A 1O4LA 3OP0A 1CJ1A 3QWYA 3PSJA 4XZ1A 1NRVA 1O48A 2LQNA 2CS0A 2KGYA 1Y1UA 1BHHA 3MXYA 3K2TA 3VRPA 2AOBA 3OB2B 5GJHA 4NWGA 3M7FA 1LKKA 2JYQA 2H8HA 1MILA 2GE9A 1O4GA 1RJAA 3GQIB 1F1WA 1MW4A 2CRHA 2DVJA 1BHFA 4K45A 1R1SA 4K11A 1TCEA 1BFIA 1KC2A 1M61A 1BFJA 1SHAA 1FBVA 1AB2A 1KSWA 2EO3A 3PJPA 3S8LA 1A07A 2L3TA 2IZVA 2ABLA 3VS3A 2IUGA 4EY0A 1M27A 2EYZA 1XA6A 2L6KA 2QMSA 3S8NA 1R1QA 1AOUF 1A1EA 1CSZA 1A1CA 4GL9E 1KA6A 2CR4A 3US4A 5EEQA 5HKZA 4M4ZA 2HCKA 3VS7A 2SRCA 5IBSA 1SKJA 3S9KA 1O4KA 2EKXA 4GPLB 1Y57A 5KAZA 1QADA 2CIAA 4A4CA 2K7AB 3VRZA 5DF6A 4F59A 3VS6A 2CI8A 1GRIA 1B47A 2DLYA 1FMKA 2PLEA 1O4NA 2FCIA 2MRKA 1AOTF 1F2FA 4P9ZA 3TL0A 1BKMA 3VS2A 1O45A 2SHPA 2GSBA 1O4FA 5HKWA 4FBNA 1LUIA 3VS4A 2MK2A 4E68A 1JYRA 3IMJA 2EO6A 1RQQC 1O4EA 1LCJA 2LCTA 2YSXA 2MC1A 3VS5A 4K2RA 4K44A 1X0NA 1IS0A 3N8MA 2PNAA 1AD5A 3PS5A 1FBZA 3HIZB 1OO4A 4U1PA 1IJRA 1A1AA 1A08A 3ZNIA 4D8KA 1AYDA 2HMHA 1OPLA 4QSYA 2HDXA 3GXXA 4H34A 1O4CA 2CBLA 1A09A 4U17A 1BHHB 3BUMB 3C7IA 2ETZA 3CXLA 3BUWB 1ZFPE 5AULA 1CWEA 3OVEA 1A1BA 2PNBA 2LNWA 2FO0A 1BM2A 1AYAA 3EAZA 1HCTB 2H46E 2XP1A 1O42A 4OHEA 2EL8A 4P9VA 1SPRA 4E93A 3CD3A 2RMXA 1O49A 1O4RA 1O47A 1K9AA 2L4KA 1SPSA 2DLZA 4JGHA 3HCKA 3VRYA 5DC4A 1I3ZA 1RPYA 1OO3A 1FYRA 5EELA 4GWFA 1BKLA 1O4QA 5EHPA 3CBLA 5J3XA 3CWGA 1O4OA 1LCKA 2OQ1A 1BLKA 3VROA 2CI9A 5D0JA 2C0IA 3HHMB 2DCRA 1O4JA 4OHIA 2MQIA 2RVFA 3GXWA 1LUMA 3PLFB 4LUEA 2Y3AB 3VS0A 1JYUA 1G83A 2Y1NA 5AXIA 2B3OA 2DM0A 2AUGA 1BF5A 1FU6A 5EG3B 4X6SA 4F5BA 1BMBA 2IUIA 2BBUA 2KNOA 1TZEE 1X27A 4OHDA 1O41A 1NZVA 2C9WA 4F5AA 3KFJA 1SHDA 2HUWA 5IBMA 1SHBA 3LYVA 3VRNA 2C0TA 1NZLA 5I6VA 4EIHA 1JWOA 1LUKA 3VS1A 1O43A 2LNXA 3IN7A 1A81A 3QWXX 1R1PA 3BKBA 2EU0A 2YU7A 3PQZA 3MXCA 1LKLA 1D4TA 2DX0A 1D4WA 3IMDA 1JU5A 1QCFA 1O4HA 4XZ0A 1UUSA 3PFVA 3PSKA 2AOAA 3N84A 3TKZA 3VRRA 1O4BA 1O4AA 4WWQA 1AYBA 3VRQA 5EHRA 3IN8A 1P13A 3UF4A 3BUXB 2PTKA 4DGXA 1CSYA 2VIFA 1PICA 1HCSB 1O4IA 3BUNB 1WQUA 5HKYA 5DC0B 1FU5A 1UURA 3MAZA 3OB1B 2HDVA 2OZOA 4LUDA 1O46A 4OHHA 5BO4A 4DGPA 3EACA 4A4BA 1YVHA 1X6CA 1YVLA 4H1OA 1OPKA 2LRAA 1KA7A 1O4PA 1Z3KA 5GJIA 2MRJA 1LUNA 2LQWA 4JE4A 1O4MA 2RSYA 2Y1MA 4JEGA 4FL2A 3WA4A 1O4DA 1CWDL 3OV1A 4L1BB 3K2MA 3BUOB 1BLJA 2K79B 5CDWA 1H9OA 5DC9A 3S8OA 2KK6A 2PLDA 3NHNA 2IUHA 4FL3A 4NWFA 1D1ZA 1GHUA 2C0OA 2EOBA 2ECDA 2EYVA 2EYYA 1JYQA 3T04A 1AYCA 1FHSA 4TZIA 2H5KA 4ROJA 2RORA 3N7YA
chains in the Genus database with same CATH topology
4OHLA 1QG1E 1O44A 3UYOA 3VGOA 1BG1A 1O4LA 3OP0A 1CJ1A 3QWYA 3PSJA 4XZ1A 1NRVA 1O48A 2LQNA 2CS0A 1Y1UA 1BHHA 3MXYA 3VRPA 2AOBA 3OB2B 5GJHA 4NWGA 3M7FA 1LKKA 2JYQA 2H8HA 1MILA 2GE9A 1O4GA 1RJAA 3GQIB 1F1WA 1MW4A 2CRHA 2DVJA 1BHFA 4K45A 1R1SA 4K11A 1TCEA 1BFIA 1KC2A 1M61A 1BFJA 1SHAA 1FBVA 1AB2A 1KSWA 2EO3A 3PJPA 3S8LA 1A07A 2L3TA 2IZVA 2ABLA 3VS3A 2IUGA 4EY0A 1M27A 2EYZA 1XA6A 2L6KA 2QMSA 3S8NA 1R1QA 1AOUF 1A1EA 1CSZA 1A1CA 4GL9E 1KA6A 2CR4A 3US4A 5EEQA 5HKZA 4M4ZA 2HCKA 3VS7A 2SRCA 5IBSA 1SKJA 3S9KA 1O4KA 2EKXA 4GPLB 1Y57A 5KAZA 1QADA 2CIAA 4A4CA 2K7AB 3VRZA 5DF6A 4F59A 3VS6A 2CI8A 1GRIA 1B47A 2DLYA 1FMKA 2PLEA 1O4NA 2FCIA 2MRKA 1AOTF 1F2FA 4P9ZA 3TL0A 1BKMA 3VS2A 1O45A 2SHPA 2GSBA 1O4FA 5HKWA 4FBNA 1LUIA 3VS4A 2MK2A 4E68A 1JYRA 3IMJA 2EO6A 1RQQC 1O4EA 1LCJA 2LCTA 2YSXA 2MC1A 3VS5A 4K2RA 4K44A 1X0NA 1IS0A 3N8MA 2PNAA 1AD5A 3PS5A 1FBZA 3HIZB 1OO4A 4U1PA 1IJRA 1A1AA 1A08A 3ZNIA 4D8KA 1AYDA 2HMHA 1OPLA 4QSYA 2HDXA 3GXXA 4H34A 1O4CA 2CBLA 1A09A 4U17A 1BHHB 3BUMB 3C7IA 2ETZA 3CXLA 3BUWB 1ZFPE 5AULA 1CWEA 3OVEA 1A1BA 2PNBA 2LNWA 2FO0A 1BM2A 1AYAA 3EAZA 1HCTB 2H46E 2XP1A 1O42A 4OHEA 2EL8A 4P9VA 1SPRA 4E93A 3CD3A 2RMXA 1O49A 1O4RA 1O47A 1K9AA 2L4KA 1SPSA 2DLZA 4JGHA 3HCKA 3VRYA 5DC4A 1I3ZA 1RPYA 1OO3A 1FYRA 5EELA 4GWFA 1BKLA 1O4QA 5EHPA 3CBLA 5J3XA 3CWGA 1O4OA 1LCKA 2OQ1A 1BLKA 3VROA 2CI9A 5D0JA 2C0IA 3HHMB 2DCRA 1O4JA 4OHIA 2MQIA 2RVFA 3GXWA 1LUMA 3PLFB 4LUEA 2Y3AB 3VS0A 1JYUA 1G83A 2Y1NA 5AXIA 2B3OA 2DM0A 2AUGA 1BF5A 1FU6A 5EG3B 4X6SA 4F5BA 1BMBA 2IUIA 2BBUA 2KNOA 1TZEE 1X27A 4OHDA 1O41A 1NZVA 2C9WA 4F5AA 3KFJA 1SHDA 2HUWA 5IBMA 1SHBA 3VRNA 2C0TA 1NZLA 5I6VA 4EIHA 1JWOA 1LUKA 3VS1A 1O43A 2LNXA 3IN7A 1A81A 3QWXX 1R1PA 3BKBA 2EU0A 2YU7A 3PQZA 3MXCA 1LKLA 1D4TA 2DX0A 1D4WA 3IMDA 1JU5A 1QCFA 1O4HA 4XZ0A 1UUSA 3PFVA 3PSKA 2AOAA 3N84A 3TKZA 3VRRA 1O4BA 1O4AA 4WWQA 1AYBA 3VRQA 5EHRA 3IN8A 1P13A 3UF4A 3BUXB 2PTKA 4DGXA 1CSYA 2VIFA 1PICA 1HCSB 1O4IA 3BUNB 1WQUA 5HKYA 5DC0B 1FU5A 1UURA 3MAZA 3OB1B 2HDVA 2OZOA 4LUDA 1O46A 4OHHA 5BO4A 4DGPA 3EACA 4A4BA 1YVHA 1X6CA 1YVLA 4H1OA 1OPKA 1KA7A 1O4PA 1Z3KA 5GJIA 2MRJA 1LUNA 2LQWA 4JE4A 1O4MA 2RSYA 2Y1MA 4JEGA 4FL2A 3WA4A 1O4DA 1CWDL 3OV1A 4L1BB 3K2MA 3BUOB 1BLJA 2K79B 5CDWA 5DC9A 1H9OA 3S8OA 2KK6A 2PLDA 3NHNA 2IUHA 4FL3A 4NWFA 1D1ZA 1GHUA 2C0OA 2EOBA 2ECDA 2EYVA 2EYYA 1JYQA 3T04A 1AYCA 1FHSA 4TZIA 2H5KA 4ROJA 2RORA 3N7YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OHL A;  1QG1 E;  1O44 A;  3UYO A;  3VGO A;  1BG1 A;  1O4L A;  3OP0 A;  1CJ1 A;  3QWY A;  3PSJ A;  4XZ1 A;  1NRV A;  1O48 A;  2LQN A;  2CS0 A;  1Y1U A;  1BHH A;  3MXY A;  3VRP A;  2AOB A;  3OB2 B;  5GJH A;  4NWG A;  3M7F A;  1LKK A;  2JYQ A;  2H8H A;  1MIL A;  2GE9 A;  1O4G A;  1RJA A;  3GQI B;  1F1W A;  1MW4 A;  2CRH A;  2DVJ A;  1BHF A;  4K45 A;  1R1S A;  4K11 A;  1TCE A;  1BFI A;  1KC2 A;  1M61 A;  1BFJ A;  1SHA A;  1FBV A;  1AB2 A;  1KSW A;  2EO3 A;  3PJP A;  3S8L A;  1A07 A;  2L3T A;  2IZV A;  2ABL A;  3VS3 A;  2IUG A;  4EY0 A;  1M27 A;  2EYZ A;  1XA6 A;  2L6K A;  2QMS A;  3S8N A;  1R1Q A;  1AOU F;  1A1E A;  1CSZ A;  1A1C A;  4GL9 E;  1KA6 A;  2CR4 A;  3US4 A;  5EEQ A;  5HKZ A;  4M4Z A;  2HCK A;  3VS7 A;  2SRC A;  5IBS A;  1SKJ A;  3S9K A;  1O4K A;  2EKX A;  4GPL B;  1Y57 A;  5KAZ A;  1QAD A;  2CIA A;  4A4C A;  2K7A B;  3VRZ A;  5DF6 A;  4F59 A;  3VS6 A;  2CI8 A;  1GRI A;  1B47 A;  2DLY A;  1FMK A;  2PLE A;  1O4N A;  2FCI A;  2MRK A;  1AOT F;  1F2F A;  4P9Z A;  3TL0 A;  1BKM A;  3VS2 A;  1O45 A;  2SHP A;  2GSB A;  1O4F A;  5HKW A;  4FBN A;  1LUI A;  3VS4 A;  2MK2 A;  4E68 A;  1JYR A;  3IMJ A;  2EO6 A;  1RQQ C;  1O4E A;  1LCJ A;  2LCT A;  2YSX A;  2MC1 A;  3VS5 A;  4K2R A;  4K44 A;  1X0N A;  1IS0 A;  3N8M A;  2PNA A;  1AD5 A;  3PS5 A;  1FBZ A;  3HIZ B;  1OO4 A;  4U1P A;  1IJR A;  1A1A A;  1A08 A;  3ZNI A;  4D8K A;  1AYD A;  2HMH A;  1OPL A;  4QSY A;  2HDX A;  3GXX A;  4H34 A;  1O4C A;  2CBL A;  1A09 A;  4U17 A;  1BHH B;  3BUM B;  3C7I A;  2ETZ A;  3CXL A;  3BUW B;  1ZFP E;  5AUL A;  1CWE A;  3OVE A;  1A1B A;  2PNB A;  2LNW A;  2FO0 A;  1BM2 A;  1AYA A;  3EAZ A;  1HCT B;  2H46 E;  2XP1 A;  1O42 A;  4OHE A;  2EL8 A;  4P9V A;  1SPR A;  4E93 A;  3CD3 A;  2RMX A;  1O49 A;  1O4R A;  1O47 A;  1K9A A;  2L4K A;  1SPS A;  2DLZ A;  4JGH A;  3HCK A;  3VRY A;  5DC4 A;  1I3Z A;  1RPY A;  1OO3 A;  1FYR A;  5EEL A;  4GWF A;  1BKL A;  1O4Q A;  5EHP A;  3CBL A;  5J3X A;  3CWG A;  1O4O A;  1LCK A;  2OQ1 A;  1BLK A;  3VRO A;  2CI9 A;  5D0J A;  2C0I A;  3HHM B;  2DCR A;  1O4J A;  4OHI A;  2MQI A;  2RVF A;  3GXW A;  1LUM A;  3PLF B;  4LUE A;  2Y3A B;  3VS0 A;  1JYU A;  1G83 A;  2Y1N A;  5AXI A;  2B3O A;  2DM0 A;  2AUG A;  1BF5 A;  1FU6 A;  5EG3 B;  4X6S A;  4F5B A;  1BMB A;  2IUI A;  2BBU A;  2KNO A;  1TZE E;  1X27 A;  4OHD A;  1O41 A;  1NZV A;  2C9W A;  4F5A A;  3KFJ A;  1SHD A;  2HUW A;  5IBM A;  1SHB A;  3VRN A;  2C0T A;  1NZL A;  5I6V A;  4EIH A;  1JWO A;  1LUK A;  3VS1 A;  1O43 A;  2LNX A;  3IN7 A;  1A81 A;  3QWX X;  1R1P A;  3BKB A;  2EU0 A;  2YU7 A;  3PQZ A;  3MXC A;  1LKL A;  1D4T A;  2DX0 A;  1D4W A;  3IMD A;  1JU5 A;  1QCF A;  1O4H A;  4XZ0 A;  1UUS A;  3PFV A;  3PSK A;  2AOA A;  3N84 A;  3TKZ A;  3VRR A;  1O4B A;  1O4A A;  4WWQ A;  1AYB A;  3VRQ A;  5EHR A;  3IN8 A;  1P13 A;  3UF4 A;  3BUX B;  2PTK A;  4DGX A;  1CSY A;  2VIF A;  1PIC A;  1HCS B;  1O4I A;  3BUN B;  1WQU A;  5HKY A;  5DC0 B;  1FU5 A;  1UUR A;  3MAZ A;  3OB1 B;  2HDV A;  2OZO A;  4LUD A;  1O46 A;  4OHH A;  5BO4 A;  4DGP A;  3EAC A;  4A4B A;  1YVH A;  1X6C A;  1YVL A;  4H1O A;  1OPK A;  1KA7 A;  1O4P A;  1Z3K A;  5GJI A;  2MRJ A;  1LUN A;  2LQW A;  4JE4 A;  1O4M A;  2RSY A;  2Y1M A;  4JEG A;  4FL2 A;  3WA4 A;  1O4D A;  1CWD L;  3OV1 A;  4L1B B;  3K2M A;  3BUO B;  1BLJ A;  2K79 B;  5CDW A;  5DC9 A;  1H9O A;  3S8O A;  2KK6 A;  2PLD A;  3NHN A;  2IUH A;  4FL3 A;  4NWF A;  1D1Z A;  1GHU A;  2C0O A;  2EOB A;  2ECD A;  2EYV A;  2EYY A;  1JYQ A;  3T04 A;  1AYC A;  1FHS A;  4TZI A;  2H5K A;  4ROJ A;  2ROR A;  3N7Y A; 
#chains in the Genus database with same CATH topology
 4OHL A;  1QG1 E;  1O44 A;  3UYO A;  3VGO A;  1BG1 A;  1O4L A;  3OP0 A;  1CJ1 A;  3QWY A;  3PSJ A;  4XZ1 A;  1NRV A;  1O48 A;  2LQN A;  2CS0 A;  2KGY A;  1Y1U A;  1BHH A;  3MXY A;  3K2T A;  3VRP A;  2AOB A;  3OB2 B;  5GJH A;  4NWG A;  3M7F A;  1LKK A;  2JYQ A;  2H8H A;  1MIL A;  2GE9 A;  1O4G A;  1RJA A;  3GQI B;  1F1W A;  1MW4 A;  2CRH A;  2DVJ A;  1BHF A;  4K45 A;  1R1S A;  4K11 A;  1TCE A;  1BFI A;  1KC2 A;  1M61 A;  1BFJ A;  1SHA A;  1FBV A;  1AB2 A;  1KSW A;  2EO3 A;  3PJP A;  3S8L A;  1A07 A;  2L3T A;  2IZV A;  2ABL A;  3VS3 A;  2IUG A;  4EY0 A;  1M27 A;  2EYZ A;  1XA6 A;  2L6K A;  2QMS A;  3S8N A;  1R1Q A;  1AOU F;  1A1E A;  1CSZ A;  1A1C A;  4GL9 E;  1KA6 A;  2CR4 A;  3US4 A;  5EEQ A;  5HKZ A;  4M4Z A;  2HCK A;  3VS7 A;  2SRC A;  5IBS A;  1SKJ A;  3S9K A;  1O4K A;  2EKX A;  4GPL B;  1Y57 A;  5KAZ A;  1QAD A;  2CIA A;  4A4C A;  2K7A B;  3VRZ A;  5DF6 A;  4F59 A;  3VS6 A;  2CI8 A;  1GRI A;  1B47 A;  2DLY A;  1FMK A;  2PLE A;  1O4N A;  2FCI A;  2MRK A;  1AOT F;  1F2F A;  4P9Z A;  3TL0 A;  1BKM A;  3VS2 A;  1O45 A;  2SHP A;  2GSB A;  1O4F A;  5HKW A;  4FBN A;  1LUI A;  3VS4 A;  2MK2 A;  4E68 A;  1JYR A;  3IMJ A;  2EO6 A;  1RQQ C;  1O4E A;  1LCJ A;  2LCT A;  2YSX A;  2MC1 A;  3VS5 A;  4K2R A;  4K44 A;  1X0N A;  1IS0 A;  3N8M A;  2PNA A;  1AD5 A;  3PS5 A;  1FBZ A;  3HIZ B;  1OO4 A;  4U1P A;  1IJR A;  1A1A A;  1A08 A;  3ZNI A;  4D8K A;  1AYD A;  2HMH A;  1OPL A;  4QSY A;  2HDX A;  3GXX A;  4H34 A;  1O4C A;  2CBL A;  1A09 A;  4U17 A;  1BHH B;  3BUM B;  3C7I A;  2ETZ A;  3CXL A;  3BUW B;  1ZFP E;  5AUL A;  1CWE A;  3OVE A;  1A1B A;  2PNB A;  2LNW A;  2FO0 A;  1BM2 A;  1AYA A;  3EAZ A;  1HCT B;  2H46 E;  2XP1 A;  1O42 A;  4OHE A;  2EL8 A;  4P9V A;  1SPR A;  4E93 A;  3CD3 A;  2RMX A;  1O49 A;  1O4R A;  1O47 A;  1K9A A;  2L4K A;  1SPS A;  2DLZ A;  4JGH A;  3HCK A;  3VRY A;  5DC4 A;  1I3Z A;  1RPY A;  1OO3 A;  1FYR A;  5EEL A;  4GWF A;  1BKL A;  1O4Q A;  5EHP A;  3CBL A;  5J3X A;  3CWG A;  1O4O A;  1LCK A;  2OQ1 A;  1BLK A;  3VRO A;  2CI9 A;  5D0J A;  2C0I A;  3HHM B;  2DCR A;  1O4J A;  4OHI A;  2MQI A;  2RVF A;  3GXW A;  1LUM A;  3PLF B;  4LUE A;  2Y3A B;  3VS0 A;  1JYU A;  1G83 A;  2Y1N A;  5AXI A;  2B3O A;  2DM0 A;  2AUG A;  1BF5 A;  1FU6 A;  5EG3 B;  4X6S A;  4F5B A;  1BMB A;  2IUI A;  2BBU A;  2KNO A;  1TZE E;  1X27 A;  4OHD A;  1O41 A;  1NZV A;  2C9W A;  4F5A A;  3KFJ A;  1SHD A;  2HUW A;  5IBM A;  1SHB A;  3LYV A;  3VRN A;  2C0T A;  1NZL A;  5I6V A;  4EIH A;  1JWO A;  1LUK A;  3VS1 A;  1O43 A;  2LNX A;  3IN7 A;  1A81 A;  3QWX X;  1R1P A;  3BKB A;  2EU0 A;  2YU7 A;  3PQZ A;  3MXC A;  1LKL A;  1D4T A;  2DX0 A;  1D4W A;  3IMD A;  1JU5 A;  1QCF A;  1O4H A;  4XZ0 A;  1UUS A;  3PFV A;  3PSK A;  2AOA A;  3N84 A;  3TKZ A;  3VRR A;  1O4B A;  1O4A A;  4WWQ A;  1AYB A;  3VRQ A;  5EHR A;  3IN8 A;  1P13 A;  3UF4 A;  3BUX B;  2PTK A;  4DGX A;  1CSY A;  2VIF A;  1PIC A;  1HCS B;  1O4I A;  3BUN B;  1WQU A;  5HKY A;  5DC0 B;  1FU5 A;  1UUR A;  3MAZ A;  3OB1 B;  2HDV A;  2OZO A;  4LUD A;  1O46 A;  4OHH A;  5BO4 A;  4DGP A;  3EAC A;  4A4B A;  1YVH A;  1X6C A;  1YVL A;  4H1O A;  1OPK A;  2LRA A;  1KA7 A;  1O4P A;  1Z3K A;  5GJI A;  2MRJ A;  1LUN A;  2LQW A;  4JE4 A;  1O4M A;  2RSY A;  2Y1M A;  4JEG A;  4FL2 A;  3WA4 A;  1O4D A;  1CWD L;  3OV1 A;  4L1B B;  3K2M A;  3BUO B;  1BLJ A;  2K79 B;  5CDW A;  1H9O A;  5DC9 A;  3S8O A;  2KK6 A;  2PLD A;  3NHN A;  2IUH A;  4FL3 A;  4NWF A;  1D1Z A;  1GHU A;  2C0O A;  2EOB A;  2ECD A;  2EYV A;  2EYY A;  1JYQ A;  3T04 A;  1AYC A;  1FHS A;  4TZI A;  2H5K A;  4ROJ A;  2ROR A;  3N7Y A; 
#chains in the Genus database with same CATH homology
 4OHL A;  1QG1 E;  1O44 A;  3UYO A;  3VGO A;  1BG1 A;  1O4L A;  3OP0 A;  1CJ1 A;  3QWY A;  3PSJ A;  4XZ1 A;  1NRV A;  1O48 A;  2LQN A;  2CS0 A;  1Y1U A;  1BHH A;  3MXY A;  3VRP A;  2AOB A;  3OB2 B;  5GJH A;  4NWG A;  3M7F A;  1LKK A;  2JYQ A;  2H8H A;  1MIL A;  2GE9 A;  1O4G A;  1RJA A;  3GQI B;  1F1W A;  1MW4 A;  2CRH A;  2DVJ A;  1BHF A;  4K45 A;  1R1S A;  4K11 A;  1TCE A;  1BFI A;  1KC2 A;  1M61 A;  1BFJ A;  1SHA A;  1FBV A;  1AB2 A;  1KSW A;  2EO3 A;  3PJP A;  3S8L A;  1A07 A;  2L3T A;  2IZV A;  2ABL A;  3VS3 A;  2IUG A;  4EY0 A;  1M27 A;  2EYZ A;  1XA6 A;  2L6K A;  2QMS A;  3S8N A;  1R1Q A;  1AOU F;  1A1E A;  1CSZ A;  1A1C A;  4GL9 E;  1KA6 A;  2CR4 A;  3US4 A;  5EEQ A;  5HKZ A;  4M4Z A;  2HCK A;  3VS7 A;  2SRC A;  5IBS A;  1SKJ A;  3S9K A;  1O4K A;  2EKX A;  4GPL B;  1Y57 A;  5KAZ A;  1QAD A;  2CIA A;  4A4C A;  2K7A B;  3VRZ A;  5DF6 A;  4F59 A;  3VS6 A;  2CI8 A;  1GRI A;  1B47 A;  2DLY A;  1FMK A;  2PLE A;  1O4N A;  2FCI A;  2MRK A;  1AOT F;  1F2F A;  4P9Z A;  3TL0 A;  1BKM A;  3VS2 A;  1O45 A;  2SHP A;  2GSB A;  1O4F A;  5HKW A;  4FBN A;  1LUI A;  3VS4 A;  2MK2 A;  4E68 A;  1JYR A;  3IMJ A;  2EO6 A;  1RQQ C;  1O4E A;  1LCJ A;  2LCT A;  2YSX A;  2MC1 A;  3VS5 A;  4K2R A;  4K44 A;  1X0N A;  1IS0 A;  3N8M A;  2PNA A;  1AD5 A;  3PS5 A;  1FBZ A;  3HIZ B;  1OO4 A;  4U1P A;  1IJR A;  1A1A A;  1A08 A;  3ZNI A;  4D8K A;  1AYD A;  2HMH A;  1OPL A;  4QSY A;  2HDX A;  3GXX A;  4H34 A;  1O4C A;  2CBL A;  1A09 A;  4U17 A;  1BHH B;  3BUM B;  3C7I A;  2ETZ A;  3CXL A;  3BUW B;  1ZFP E;  5AUL A;  1CWE A;  3OVE A;  1A1B A;  2PNB A;  2LNW A;  2FO0 A;  1BM2 A;  1AYA A;  3EAZ A;  1HCT B;  2H46 E;  2XP1 A;  1O42 A;  4OHE A;  2EL8 A;  4P9V A;  1SPR A;  4E93 A;  3CD3 A;  2RMX A;  1O49 A;  1O4R A;  1O47 A;  1K9A A;  2L4K A;  1SPS A;  2DLZ A;  4JGH A;  3HCK A;  3VRY A;  5DC4 A;  1I3Z A;  1RPY A;  1OO3 A;  1FYR A;  5EEL A;  4GWF A;  1BKL A;  1O4Q A;  5EHP A;  3CBL A;  5J3X A;  3CWG A;  1O4O A;  1LCK A;  2OQ1 A;  1BLK A;  3VRO A;  2CI9 A;  5D0J A;  2C0I A;  3HHM B;  2DCR A;  1O4J A;  4OHI A;  2MQI A;  2RVF A;  3GXW A;  1LUM A;  3PLF B;  4LUE A;  2Y3A B;  3VS0 A;  1JYU A;  1G83 A;  2Y1N A;  5AXI A;  2B3O A;  2DM0 A;  2AUG A;  1BF5 A;  1FU6 A;  5EG3 B;  4X6S A;  4F5B A;  1BMB A;  2IUI A;  2BBU A;  2KNO A;  1TZE E;  1X27 A;  4OHD A;  1O41 A;  1NZV A;  2C9W A;  4F5A A;  3KFJ A;  1SHD A;  2HUW A;  5IBM A;  1SHB A;  3VRN A;  2C0T A;  1NZL A;  5I6V A;  4EIH A;  1JWO A;  1LUK A;  3VS1 A;  1O43 A;  2LNX A;  3IN7 A;  1A81 A;  3QWX X;  1R1P A;  3BKB A;  2EU0 A;  2YU7 A;  3PQZ A;  3MXC A;  1LKL A;  1D4T A;  2DX0 A;  1D4W A;  3IMD A;  1JU5 A;  1QCF A;  1O4H A;  4XZ0 A;  1UUS A;  3PFV A;  3PSK A;  2AOA A;  3N84 A;  3TKZ A;  3VRR A;  1O4B A;  1O4A A;  4WWQ A;  1AYB A;  3VRQ A;  5EHR A;  3IN8 A;  1P13 A;  3UF4 A;  3BUX B;  2PTK A;  4DGX A;  1CSY A;  2VIF A;  1PIC A;  1HCS B;  1O4I A;  3BUN B;  1WQU A;  5HKY A;  5DC0 B;  1FU5 A;  1UUR A;  3MAZ A;  3OB1 B;  2HDV A;  2OZO A;  4LUD A;  1O46 A;  4OHH A;  5BO4 A;  4DGP A;  3EAC A;  4A4B A;  1YVH A;  1X6C A;  1YVL A;  4H1O A;  1OPK A;  1KA7 A;  1O4P A;  1Z3K A;  5GJI A;  2MRJ A;  1LUN A;  2LQW A;  4JE4 A;  1O4M A;  2RSY A;  2Y1M A;  4JEG A;  4FL2 A;  3WA4 A;  1O4D A;  1CWD L;  3OV1 A;  4L1B B;  3K2M A;  3BUO B;  1BLJ A;  2K79 B;  5CDW A;  5DC9 A;  1H9O A;  3S8O A;  2KK6 A;  2PLD A;  3NHN A;  2IUH A;  4FL3 A;  4NWF A;  1D1Z A;  1GHU A;  2C0O A;  2EOB A;  2ECD A;  2EYV A;  2EYY A;  1JYQ A;  3T04 A;  1AYC A;  1FHS A;  4TZI A;  2H5K A;  4ROJ A;  2ROR A;  3N7Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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