2HUWA

X-ray crystal structure of the grb2 sh2 domain complexed to a constrained and cyclopropane-derived ligand
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
101
structure length
101
Chain Sequence
MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 25
structure length 101
sequence length 101
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2huwA00
1LUKA 1B47A 1A1AA 4U1PA 2DCRA 2IZVA 1FMKA 4FL2A 1A09A 5HKYA 2Y1NA 2RMXA 1LKLA 1BM2A 3MXCA 3IN8A 2AOAA 4OHHA 1X6CA 1AYCA 2MC1A 1Z3KA 1AB2A 4DGPA 1O4CA 4A4CA 5EHRA 1IS0A 1BF5A 1TCEA 1GRIA 1BFJA 2CRHA 1BMBA 4D8KA 5DF6A 2Y3AB 3M7FA 3PLFB 1KSWA 2H46E 3VS6A 1AYDA 5AULA 5EG3B 1I3ZA 1R1SA 3N84A 3QWYA 1O48A 1A1EA 1JYRA 4H1OA 2EL8A 3PSJA 3VS3A 4QSYA 1K9AA 1HCTB 1O4AA 5GJHA 1FBZA 1FBVA 3HIZB 2MQIA 4H34A 1O4EA 3OV1A 4LUEA 1JU5A 1OO4A 4FL3A 3PSKA 2CI8A 5D0JA 1A1BA 2DLYA 3K2MA 3PS5A 1O4PA 1NRVA 1XA6A 2IUIA 1QCFA 3S8NA 1H9OA 3BUNB 1D4TA 3VRYA 2IUGA 4JGHA 3VGOA 3NHNA 3BUXB 1O4DA 1QADA 2HCKA 1O47A 2HUWA 1CJ1A 4GPLB 3BUOB 1O4OA 2BBUA 1F1WA 2CBLA 2ECDA 3VS2A 2DVJA 2HDVA 1BKMA 1D1ZA 1RJAA 3HCKA 1KA6A 2QMSA 1OPLA 4P9ZA 3PFVA 1RPYA 2EYYA 2LQNA 2GSBA 1A1CA 2EYVA 2C0IA 1R1PA 1HCSB 1FHSA 2YSXA 2LNXA 1O41A 4K45A 3VS5A 1BLJA 3EAZA 1X27A 2RVFA 3VRQA 1SPRA 2OQ1A 2FCIA 1Y57A 2DX0A 1LCKA 1JWOA 1QG1E 2KK6A 4EY0A 1CSZA 2L4KA 2RORA 2CR4A 2DM0A 1O46A 3S9KA 2K7AB 5IBMA 4GWFA 2PLDA 1O49A 5BO4A 3VS0A 3OB1B 4NWFA 4EIHA 3HHMB 4LUDA 4OHDA 2OZOA 1O4KA 1YVHA 1FU5A 3CD3A 2EO3A 1RQQC 1X0NA 3IMDA 3C7IA 1TZEE 2Y1MA 1YVLA 3VRZA 1CWDL 1O44A 4DGXA 2MK2A 3T04A 2EKXA 3GQIB 4XZ0A 2AOBA 4K44A 4K11A 1LUIA 1BLKA 4XZ1A 2XP1A 3VRNA 3OB2B 3VRPA 1NZVA 1P13A 2C9WA 4K2RA 2H8HA 1BHHA 1BG1A 1M27A 1AOTF 1NZLA 2IUHA 1O4IA 4OHEA 1SPSA 1BKLA 3BKBA 1LKKA 3VS4A 1AYBA 1AOUF 1OO3A 2HDXA 1BHHB 1O4HA 3N8MA 5I6VA 3IMJA 1BFIA 4JEGA 1PICA 3UF4A 2EOBA 2PTKA 1JYQA 5IBSA 2RSYA 4ROJA 2C0OA 2SRCA 3TL0A 3WA4A 2AUGA 4JE4A 1GHUA 2EU0A 1O4QA 1O42A 3OVEA 2HMHA 3PJPA 1KA7A 3KFJA 2CIAA 5EEQA 1O4MA 2ETZA 3GXXA 3US4A 3MXYA 4F5BA 1FU6A 1O4RA 4P9VA 1LCJA 1AD5A 1F2FA 4NWGA 2L6KA 1MW4A 1IJRA 4M4ZA 3TKZA 2LNWA 3N7YA 1R1QA 2PLEA 1O4BA 2FO0A 5EELA 1A81A 1AYAA 5HKZA 5DC4A 3CBLA 1SKJA 5GJIA 2EO6A 2LQWA 1O4FA 2CI9A 2EYZA 3ZNIA 2MRJA 4A4BA 4E93A 1A08A 5CDWA 4F59A 2CS0A 1Y1UA 2B3OA 4FBNA 1JYUA 2K79B 2PNBA 1ZFPE 4F5AA 1O4JA 1MILA 1O45A 4E68A 3VROA 4TZIA 4X6SA 3BUWB 3CXLA 2MRKA 1LUNA 1O4NA 3S8LA 5DC9A 1CSYA 1O4LA 4GL9E 1SHAA 3PQZA 2ABLA 3UYOA 3BUMB 3VS7A 1OPKA 1SHDA 1CWEA 3GXWA 2YU7A 2LCTA 1O4GA 4OHIA 5AXIA 5DC0B 3MAZA 3S8OA 2VIFA 1SHBA 4L1BB 3OP0A 3VRRA 1BHFA 2C0TA 1M61A 1FYRA 1D4WA 5HKWA 2L3TA 5KAZA 2GE9A 3IN7A 1G83A 3VS1A 4OHLA 1O43A 1UURA 3CWGA 2H5KA 1WQUA 4U17A 2KNOA 2JYQA 1KC2A 5EHPA 1LUMA 2DLZA 2SHPA 3QWXX 4WWQA 2PNAA 3EACA 1UUSA 5J3XA 1A07A
chains in the Genus database with same CATH superfamily
1LUKA 1B47A 1A1AA 4U1PA 2DCRA 2IZVA 1FMKA 4FL2A 1A09A 5HKYA 2Y1NA 2RMXA 1LKLA 1BM2A 3MXCA 3IN8A 2AOAA 4OHHA 1X6CA 1AYCA 2MC1A 1Z3KA 1AB2A 4DGPA 1O4CA 4A4CA 5EHRA 1IS0A 1BF5A 1TCEA 1GRIA 1BFJA 2CRHA 1BMBA 4D8KA 5DF6A 2Y3AB 3M7FA 3PLFB 1KSWA 2H46E 3VS6A 1AYDA 5AULA 5EG3B 1I3ZA 1R1SA 3N84A 3QWYA 1O48A 1A1EA 1JYRA 4H1OA 2EL8A 3PSJA 3VS3A 2LRAA 4QSYA 1K9AA 1HCTB 1O4AA 5GJHA 1FBZA 1FBVA 3HIZB 2MQIA 4H34A 1O4EA 3OV1A 4LUEA 2KGYA 1JU5A 1OO4A 4FL3A 3PSKA 2CI8A 5D0JA 1A1BA 2DLYA 3K2MA 3PS5A 1O4PA 1NRVA 1XA6A 2IUIA 1QCFA 3S8NA 1H9OA 3BUNB 1D4TA 3VRYA 2IUGA 4JGHA 3VGOA 3NHNA 3BUXB 1O4DA 1QADA 2HCKA 1O47A 2HUWA 3K2TA 1CJ1A 4GPLB 3BUOB 1O4OA 2BBUA 1F1WA 2CBLA 2ECDA 3VS2A 2DVJA 2HDVA 1BKMA 1D1ZA 1RJAA 3HCKA 1KA6A 2QMSA 1OPLA 4P9ZA 3PFVA 1RPYA 2EYYA 2LQNA 2GSBA 1A1CA 2EYVA 2C0IA 1R1PA 1HCSB 1FHSA 2YSXA 2LNXA 1O41A 4K45A 3VS5A 1BLJA 3EAZA 1X27A 2RVFA 3VRQA 1SPRA 2OQ1A 2FCIA 1Y57A 2DX0A 1LCKA 1JWOA 1QG1E 2KK6A 4EY0A 1CSZA 2L4KA 2RORA 2CR4A 2DM0A 1O46A 3S9KA 2K7AB 5IBMA 4GWFA 2PLDA 1O49A 5BO4A 3VS0A 3OB1B 4NWFA 4EIHA 3HHMB 4LUDA 4OHDA 2OZOA 1O4KA 1YVHA 1FU5A 3CD3A 2EO3A 1RQQC 1X0NA 3IMDA 3C7IA 1TZEE 2Y1MA 1YVLA 3VRZA 1CWDL 1O44A 4DGXA 2MK2A 3T04A 2EKXA 3GQIB 4XZ0A 2AOBA 4K44A 4K11A 1LUIA 1BLKA 4XZ1A 2XP1A 3VRNA 3OB2B 3VRPA 1NZVA 1P13A 2C9WA 4K2RA 2H8HA 1BHHA 1BG1A 1M27A 1AOTF 1NZLA 2IUHA 1O4IA 4OHEA 1SPSA 1BKLA 3BKBA 1LKKA 3VS4A 1AYBA 1AOUF 1OO3A 3LYVA 2HDXA 1BHHB 1O4HA 3N8MA 5I6VA 3IMJA 1BFIA 4JEGA 1PICA 3UF4A 2EOBA 2PTKA 1JYQA 5IBSA 2RSYA 4ROJA 2C0OA 2SRCA 3TL0A 3WA4A 2AUGA 4JE4A 1GHUA 2EU0A 1O4QA 1O42A 3OVEA 2HMHA 3PJPA 1KA7A 3KFJA 2CIAA 5EEQA 1O4MA 2ETZA 3GXXA 3US4A 3MXYA 4F5BA 1FU6A 1O4RA 4P9VA 1LCJA 1AD5A 1F2FA 4NWGA 2L6KA 1MW4A 1IJRA 4M4ZA 3TKZA 2LNWA 3N7YA 1R1QA 2PLEA 1O4BA 2FO0A 5EELA 1A81A 1AYAA 5HKZA 5DC4A 3CBLA 1SKJA 5GJIA 2EO6A 2LQWA 1O4FA 2CI9A 2EYZA 3ZNIA 2MRJA 4A4BA 4E93A 1A08A 5CDWA 4F59A 2CS0A 1Y1UA 2B3OA 4FBNA 1JYUA 2K79B 2PNBA 1ZFPE 4F5AA 1O4JA 1MILA 1O45A 4E68A 3VROA 4TZIA 4X6SA 3BUWB 3CXLA 2MRKA 1LUNA 1O4NA 3S8LA 5DC9A 1CSYA 1O4LA 4GL9E 1SHAA 3PQZA 2ABLA 3UYOA 3BUMB 3VS7A 1OPKA 1SHDA 1CWEA 3GXWA 2YU7A 2LCTA 1O4GA 4OHIA 5AXIA 5DC0B 3MAZA 3S8OA 2VIFA 1SHBA 4L1BB 3OP0A 3VRRA 1BHFA 2C0TA 1M61A 1FYRA 1D4WA 5HKWA 2L3TA 5KAZA 2GE9A 3IN7A 1G83A 3VS1A 4OHLA 1O43A 1UURA 3CWGA 2H5KA 1WQUA 4U17A 2KNOA 2JYQA 1KC2A 5EHPA 1LUMA 2DLZA 2SHPA 3QWXX 4WWQA 2PNAA 3EACA 1UUSA 5J3XA 1A07A
chains in the Genus database with same CATH topology
1LUKA 1B47A 1A1AA 4U1PA 2DCRA 2IZVA 1FMKA 4FL2A 1A09A 5HKYA 2Y1NA 2RMXA 1LKLA 1BM2A 3MXCA 3IN8A 2AOAA 4OHHA 1X6CA 1AYCA 2MC1A 1Z3KA 1AB2A 4DGPA 1O4CA 4A4CA 5EHRA 1IS0A 1BF5A 1TCEA 1GRIA 1BFJA 2CRHA 1BMBA 4D8KA 5DF6A 2Y3AB 3M7FA 3PLFB 1KSWA 2H46E 3VS6A 1AYDA 5AULA 5EG3B 1I3ZA 1R1SA 3N84A 3QWYA 1O48A 1A1EA 1JYRA 4H1OA 2EL8A 3PSJA 3VS3A 4QSYA 1K9AA 1HCTB 1O4AA 5GJHA 1FBZA 1FBVA 3HIZB 2MQIA 4H34A 1O4EA 3OV1A 4LUEA 1JU5A 1OO4A 4FL3A 3PSKA 2CI8A 5D0JA 1A1BA 2DLYA 3K2MA 3PS5A 1O4PA 1NRVA 1XA6A 2IUIA 1QCFA 3S8NA 1H9OA 3BUNB 1D4TA 3VRYA 2IUGA 4JGHA 3VGOA 3NHNA 3BUXB 1O4DA 1QADA 2HCKA 1O47A 2HUWA 1CJ1A 4GPLB 3BUOB 1O4OA 2BBUA 1F1WA 2CBLA 2ECDA 3VS2A 2DVJA 2HDVA 1BKMA 1D1ZA 1RJAA 3HCKA 1KA6A 2QMSA 1OPLA 4P9ZA 3PFVA 1RPYA 2EYYA 2LQNA 2GSBA 1A1CA 2EYVA 2C0IA 1R1PA 1HCSB 1FHSA 2YSXA 2LNXA 1O41A 4K45A 3VS5A 1BLJA 3EAZA 1X27A 2RVFA 3VRQA 1SPRA 2OQ1A 2FCIA 1Y57A 2DX0A 1LCKA 1JWOA 1QG1E 2KK6A 4EY0A 1CSZA 2L4KA 2RORA 2CR4A 2DM0A 1O46A 3S9KA 2K7AB 5IBMA 4GWFA 2PLDA 1O49A 5BO4A 3VS0A 3OB1B 4NWFA 4EIHA 3HHMB 4LUDA 4OHDA 2OZOA 1O4KA 1YVHA 1FU5A 3CD3A 2EO3A 1RQQC 1X0NA 3IMDA 3C7IA 1TZEE 2Y1MA 1YVLA 3VRZA 1CWDL 1O44A 4DGXA 2MK2A 3T04A 2EKXA 3GQIB 4XZ0A 2AOBA 4K44A 4K11A 1LUIA 1BLKA 4XZ1A 2XP1A 3VRNA 3OB2B 3VRPA 1NZVA 1P13A 2C9WA 4K2RA 2H8HA 1BHHA 1BG1A 1M27A 1AOTF 1NZLA 2IUHA 1O4IA 4OHEA 1SPSA 1BKLA 3BKBA 1LKKA 3VS4A 1AYBA 1AOUF 1OO3A 2HDXA 1BHHB 1O4HA 3N8MA 5I6VA 3IMJA 1BFIA 4JEGA 1PICA 3UF4A 2EOBA 2PTKA 1JYQA 5IBSA 2RSYA 4ROJA 2C0OA 2SRCA 3TL0A 3WA4A 2AUGA 4JE4A 1GHUA 2EU0A 1O4QA 1O42A 3OVEA 2HMHA 3PJPA 1KA7A 3KFJA 2CIAA 5EEQA 1O4MA 2ETZA 3GXXA 3US4A 3MXYA 4F5BA 1FU6A 1O4RA 4P9VA 1LCJA 1AD5A 1F2FA 4NWGA 2L6KA 1MW4A 1IJRA 4M4ZA 3TKZA 2LNWA 3N7YA 1R1QA 2PLEA 1O4BA 2FO0A 5EELA 1A81A 1AYAA 5HKZA 5DC4A 3CBLA 1SKJA 5GJIA 2EO6A 2LQWA 1O4FA 2CI9A 2EYZA 3ZNIA 2MRJA 4A4BA 4E93A 1A08A 5CDWA 4F59A 2CS0A 1Y1UA 2B3OA 4FBNA 1JYUA 2K79B 2PNBA 1ZFPE 4F5AA 1O4JA 1MILA 1O45A 4E68A 3VROA 4TZIA 4X6SA 3BUWB 3CXLA 2MRKA 1LUNA 1O4NA 3S8LA 5DC9A 1CSYA 1O4LA 4GL9E 1SHAA 3PQZA 2ABLA 3UYOA 3BUMB 3VS7A 1OPKA 1SHDA 1CWEA 3GXWA 2YU7A 2LCTA 1O4GA 4OHIA 5AXIA 5DC0B 3MAZA 3S8OA 2VIFA 1SHBA 4L1BB 3OP0A 3VRRA 1BHFA 2C0TA 1M61A 1FYRA 1D4WA 5HKWA 2L3TA 5KAZA 2GE9A 3IN7A 1G83A 3VS1A 4OHLA 1O43A 1UURA 3CWGA 2H5KA 1WQUA 4U17A 2KNOA 2JYQA 1KC2A 5EHPA 1LUMA 2DLZA 2SHPA 3QWXX 4WWQA 2PNAA 3EACA 1UUSA 5J3XA 1A07A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LUK A;  1B47 A;  1A1A A;  4U1P A;  2DCR A;  2IZV A;  1FMK A;  4FL2 A;  1A09 A;  5HKY A;  2Y1N A;  2RMX A;  1LKL A;  1BM2 A;  3MXC A;  3IN8 A;  2AOA A;  4OHH A;  1X6C A;  1AYC A;  2MC1 A;  1Z3K A;  1AB2 A;  4DGP A;  1O4C A;  4A4C A;  5EHR A;  1IS0 A;  1BF5 A;  1TCE A;  1GRI A;  1BFJ A;  2CRH A;  1BMB A;  4D8K A;  5DF6 A;  2Y3A B;  3M7F A;  3PLF B;  1KSW A;  2H46 E;  3VS6 A;  1AYD A;  5AUL A;  5EG3 B;  1I3Z A;  1R1S A;  3N84 A;  3QWY A;  1O48 A;  1A1E A;  1JYR A;  4H1O A;  2EL8 A;  3PSJ A;  3VS3 A;  4QSY A;  1K9A A;  1HCT B;  1O4A A;  5GJH A;  1FBZ A;  1FBV A;  3HIZ B;  2MQI A;  4H34 A;  1O4E A;  3OV1 A;  4LUE A;  1JU5 A;  1OO4 A;  4FL3 A;  3PSK A;  2CI8 A;  5D0J A;  1A1B A;  2DLY A;  3K2M A;  3PS5 A;  1O4P A;  1NRV A;  1XA6 A;  2IUI A;  1QCF A;  3S8N A;  1H9O A;  3BUN B;  1D4T A;  3VRY A;  2IUG A;  4JGH A;  3VGO A;  3NHN A;  3BUX B;  1O4D A;  1QAD A;  2HCK A;  1O47 A;  2HUW A;  1CJ1 A;  4GPL B;  3BUO B;  1O4O A;  2BBU A;  1F1W A;  2CBL A;  2ECD A;  3VS2 A;  2DVJ A;  2HDV A;  1BKM A;  1D1Z A;  1RJA A;  3HCK A;  1KA6 A;  2QMS A;  1OPL A;  4P9Z A;  3PFV A;  1RPY A;  2EYY A;  2LQN A;  2GSB A;  1A1C A;  2EYV A;  2C0I A;  1R1P A;  1HCS B;  1FHS A;  2YSX A;  2LNX A;  1O41 A;  4K45 A;  3VS5 A;  1BLJ A;  3EAZ A;  1X27 A;  2RVF A;  3VRQ A;  1SPR A;  2OQ1 A;  2FCI A;  1Y57 A;  2DX0 A;  1LCK A;  1JWO A;  1QG1 E;  2KK6 A;  4EY0 A;  1CSZ A;  2L4K A;  2ROR A;  2CR4 A;  2DM0 A;  1O46 A;  3S9K A;  2K7A B;  5IBM A;  4GWF A;  2PLD A;  1O49 A;  5BO4 A;  3VS0 A;  3OB1 B;  4NWF A;  4EIH A;  3HHM B;  4LUD A;  4OHD A;  2OZO A;  1O4K A;  1YVH A;  1FU5 A;  3CD3 A;  2EO3 A;  1RQQ C;  1X0N A;  3IMD A;  3C7I A;  1TZE E;  2Y1M A;  1YVL A;  3VRZ A;  1CWD L;  1O44 A;  4DGX A;  2MK2 A;  3T04 A;  2EKX A;  3GQI B;  4XZ0 A;  2AOB A;  4K44 A;  4K11 A;  1LUI A;  1BLK A;  4XZ1 A;  2XP1 A;  3VRN A;  3OB2 B;  3VRP A;  1NZV A;  1P13 A;  2C9W A;  4K2R A;  2H8H A;  1BHH A;  1BG1 A;  1M27 A;  1AOT F;  1NZL A;  2IUH A;  1O4I A;  4OHE A;  1SPS A;  1BKL A;  3BKB A;  1LKK A;  3VS4 A;  1AYB A;  1AOU F;  1OO3 A;  2HDX A;  1BHH B;  1O4H A;  3N8M A;  5I6V A;  3IMJ A;  1BFI A;  4JEG A;  1PIC A;  3UF4 A;  2EOB A;  2PTK A;  1JYQ A;  5IBS A;  2RSY A;  4ROJ A;  2C0O A;  2SRC A;  3TL0 A;  3WA4 A;  2AUG A;  4JE4 A;  1GHU A;  2EU0 A;  1O4Q A;  1O42 A;  3OVE A;  2HMH A;  3PJP A;  1KA7 A;  3KFJ A;  2CIA A;  5EEQ A;  1O4M A;  2ETZ A;  3GXX A;  3US4 A;  3MXY A;  4F5B A;  1FU6 A;  1O4R A;  4P9V A;  1LCJ A;  1AD5 A;  1F2F A;  4NWG A;  2L6K A;  1MW4 A;  1IJR A;  4M4Z A;  3TKZ A;  2LNW A;  3N7Y A;  1R1Q A;  2PLE A;  1O4B A;  2FO0 A;  5EEL A;  1A81 A;  1AYA A;  5HKZ A;  5DC4 A;  3CBL A;  1SKJ A;  5GJI A;  2EO6 A;  2LQW A;  1O4F A;  2CI9 A;  2EYZ A;  3ZNI A;  2MRJ A;  4A4B A;  4E93 A;  1A08 A;  5CDW A;  4F59 A;  2CS0 A;  1Y1U A;  2B3O A;  4FBN A;  1JYU A;  2K79 B;  2PNB A;  1ZFP E;  4F5A A;  1O4J A;  1MIL A;  1O45 A;  4E68 A;  3VRO A;  4TZI A;  4X6S A;  3BUW B;  3CXL A;  2MRK A;  1LUN A;  1O4N A;  3S8L A;  5DC9 A;  1CSY A;  1O4L A;  4GL9 E;  1SHA A;  3PQZ A;  2ABL A;  3UYO A;  3BUM B;  3VS7 A;  1OPK A;  1SHD A;  1CWE A;  3GXW A;  2YU7 A;  2LCT A;  1O4G A;  4OHI A;  5AXI A;  5DC0 B;  3MAZ A;  3S8O A;  2VIF A;  1SHB A;  4L1B B;  3OP0 A;  3VRR A;  1BHF A;  2C0T A;  1M61 A;  1FYR A;  1D4W A;  5HKW A;  2L3T A;  5KAZ A;  2GE9 A;  3IN7 A;  1G83 A;  3VS1 A;  4OHL A;  1O43 A;  1UUR A;  3CWG A;  2H5K A;  1WQU A;  4U17 A;  2KNO A;  2JYQ A;  1KC2 A;  5EHP A;  1LUM A;  2DLZ A;  2SHP A;  3QWX X;  4WWQ A;  2PNA A;  3EAC A;  1UUS A;  5J3X A;  1A07 A; 
#chains in the Genus database with same CATH topology
 1LUK A;  1B47 A;  1A1A A;  4U1P A;  2DCR A;  2IZV A;  1FMK A;  4FL2 A;  1A09 A;  5HKY A;  2Y1N A;  2RMX A;  1LKL A;  1BM2 A;  3MXC A;  3IN8 A;  2AOA A;  4OHH A;  1X6C A;  1AYC A;  2MC1 A;  1Z3K A;  1AB2 A;  4DGP A;  1O4C A;  4A4C A;  5EHR A;  1IS0 A;  1BF5 A;  1TCE A;  1GRI A;  1BFJ A;  2CRH A;  1BMB A;  4D8K A;  5DF6 A;  2Y3A B;  3M7F A;  3PLF B;  1KSW A;  2H46 E;  3VS6 A;  1AYD A;  5AUL A;  5EG3 B;  1I3Z A;  1R1S A;  3N84 A;  3QWY A;  1O48 A;  1A1E A;  1JYR A;  4H1O A;  2EL8 A;  3PSJ A;  3VS3 A;  2LRA A;  4QSY A;  1K9A A;  1HCT B;  1O4A A;  5GJH A;  1FBZ A;  1FBV A;  3HIZ B;  2MQI A;  4H34 A;  1O4E A;  3OV1 A;  4LUE A;  2KGY A;  1JU5 A;  1OO4 A;  4FL3 A;  3PSK A;  2CI8 A;  5D0J A;  1A1B A;  2DLY A;  3K2M A;  3PS5 A;  1O4P A;  1NRV A;  1XA6 A;  2IUI A;  1QCF A;  3S8N A;  1H9O A;  3BUN B;  1D4T A;  3VRY A;  2IUG A;  4JGH A;  3VGO A;  3NHN A;  3BUX B;  1O4D A;  1QAD A;  2HCK A;  1O47 A;  2HUW A;  3K2T A;  1CJ1 A;  4GPL B;  3BUO B;  1O4O A;  2BBU A;  1F1W A;  2CBL A;  2ECD A;  3VS2 A;  2DVJ A;  2HDV A;  1BKM A;  1D1Z A;  1RJA A;  3HCK A;  1KA6 A;  2QMS A;  1OPL A;  4P9Z A;  3PFV A;  1RPY A;  2EYY A;  2LQN A;  2GSB A;  1A1C A;  2EYV A;  2C0I A;  1R1P A;  1HCS B;  1FHS A;  2YSX A;  2LNX A;  1O41 A;  4K45 A;  3VS5 A;  1BLJ A;  3EAZ A;  1X27 A;  2RVF A;  3VRQ A;  1SPR A;  2OQ1 A;  2FCI A;  1Y57 A;  2DX0 A;  1LCK A;  1JWO A;  1QG1 E;  2KK6 A;  4EY0 A;  1CSZ A;  2L4K A;  2ROR A;  2CR4 A;  2DM0 A;  1O46 A;  3S9K A;  2K7A B;  5IBM A;  4GWF A;  2PLD A;  1O49 A;  5BO4 A;  3VS0 A;  3OB1 B;  4NWF A;  4EIH A;  3HHM B;  4LUD A;  4OHD A;  2OZO A;  1O4K A;  1YVH A;  1FU5 A;  3CD3 A;  2EO3 A;  1RQQ C;  1X0N A;  3IMD A;  3C7I A;  1TZE E;  2Y1M A;  1YVL A;  3VRZ A;  1CWD L;  1O44 A;  4DGX A;  2MK2 A;  3T04 A;  2EKX A;  3GQI B;  4XZ0 A;  2AOB A;  4K44 A;  4K11 A;  1LUI A;  1BLK A;  4XZ1 A;  2XP1 A;  3VRN A;  3OB2 B;  3VRP A;  1NZV A;  1P13 A;  2C9W A;  4K2R A;  2H8H A;  1BHH A;  1BG1 A;  1M27 A;  1AOT F;  1NZL A;  2IUH A;  1O4I A;  4OHE A;  1SPS A;  1BKL A;  3BKB A;  1LKK A;  3VS4 A;  1AYB A;  1AOU F;  1OO3 A;  3LYV A;  2HDX A;  1BHH B;  1O4H A;  3N8M A;  5I6V A;  3IMJ A;  1BFI A;  4JEG A;  1PIC A;  3UF4 A;  2EOB A;  2PTK A;  1JYQ A;  5IBS A;  2RSY A;  4ROJ A;  2C0O A;  2SRC A;  3TL0 A;  3WA4 A;  2AUG A;  4JE4 A;  1GHU A;  2EU0 A;  1O4Q A;  1O42 A;  3OVE A;  2HMH A;  3PJP A;  1KA7 A;  3KFJ A;  2CIA A;  5EEQ A;  1O4M A;  2ETZ A;  3GXX A;  3US4 A;  3MXY A;  4F5B A;  1FU6 A;  1O4R A;  4P9V A;  1LCJ A;  1AD5 A;  1F2F A;  4NWG A;  2L6K A;  1MW4 A;  1IJR A;  4M4Z A;  3TKZ A;  2LNW A;  3N7Y A;  1R1Q A;  2PLE A;  1O4B A;  2FO0 A;  5EEL A;  1A81 A;  1AYA A;  5HKZ A;  5DC4 A;  3CBL A;  1SKJ A;  5GJI A;  2EO6 A;  2LQW A;  1O4F A;  2CI9 A;  2EYZ A;  3ZNI A;  2MRJ A;  4A4B A;  4E93 A;  1A08 A;  5CDW A;  4F59 A;  2CS0 A;  1Y1U A;  2B3O A;  4FBN A;  1JYU A;  2K79 B;  2PNB A;  1ZFP E;  4F5A A;  1O4J A;  1MIL A;  1O45 A;  4E68 A;  3VRO A;  4TZI A;  4X6S A;  3BUW B;  3CXL A;  2MRK A;  1LUN A;  1O4N A;  3S8L A;  5DC9 A;  1CSY A;  1O4L A;  4GL9 E;  1SHA A;  3PQZ A;  2ABL A;  3UYO A;  3BUM B;  3VS7 A;  1OPK A;  1SHD A;  1CWE A;  3GXW A;  2YU7 A;  2LCT A;  1O4G A;  4OHI A;  5AXI A;  5DC0 B;  3MAZ A;  3S8O A;  2VIF A;  1SHB A;  4L1B B;  3OP0 A;  3VRR A;  1BHF A;  2C0T A;  1M61 A;  1FYR A;  1D4W A;  5HKW A;  2L3T A;  5KAZ A;  2GE9 A;  3IN7 A;  1G83 A;  3VS1 A;  4OHL A;  1O43 A;  1UUR A;  3CWG A;  2H5K A;  1WQU A;  4U17 A;  2KNO A;  2JYQ A;  1KC2 A;  5EHP A;  1LUM A;  2DLZ A;  2SHP A;  3QWX X;  4WWQ A;  2PNA A;  3EAC A;  1UUS A;  5J3X A;  1A07 A; 
#chains in the Genus database with same CATH homology
 1LUK A;  1B47 A;  1A1A A;  4U1P A;  2DCR A;  2IZV A;  1FMK A;  4FL2 A;  1A09 A;  5HKY A;  2Y1N A;  2RMX A;  1LKL A;  1BM2 A;  3MXC A;  3IN8 A;  2AOA A;  4OHH A;  1X6C A;  1AYC A;  2MC1 A;  1Z3K A;  1AB2 A;  4DGP A;  1O4C A;  4A4C A;  5EHR A;  1IS0 A;  1BF5 A;  1TCE A;  1GRI A;  1BFJ A;  2CRH A;  1BMB A;  4D8K A;  5DF6 A;  2Y3A B;  3M7F A;  3PLF B;  1KSW A;  2H46 E;  3VS6 A;  1AYD A;  5AUL A;  5EG3 B;  1I3Z A;  1R1S A;  3N84 A;  3QWY A;  1O48 A;  1A1E A;  1JYR A;  4H1O A;  2EL8 A;  3PSJ A;  3VS3 A;  4QSY A;  1K9A A;  1HCT B;  1O4A A;  5GJH A;  1FBZ A;  1FBV A;  3HIZ B;  2MQI A;  4H34 A;  1O4E A;  3OV1 A;  4LUE A;  1JU5 A;  1OO4 A;  4FL3 A;  3PSK A;  2CI8 A;  5D0J A;  1A1B A;  2DLY A;  3K2M A;  3PS5 A;  1O4P A;  1NRV A;  1XA6 A;  2IUI A;  1QCF A;  3S8N A;  1H9O A;  3BUN B;  1D4T A;  3VRY A;  2IUG A;  4JGH A;  3VGO A;  3NHN A;  3BUX B;  1O4D A;  1QAD A;  2HCK A;  1O47 A;  2HUW A;  1CJ1 A;  4GPL B;  3BUO B;  1O4O A;  2BBU A;  1F1W A;  2CBL A;  2ECD A;  3VS2 A;  2DVJ A;  2HDV A;  1BKM A;  1D1Z A;  1RJA A;  3HCK A;  1KA6 A;  2QMS A;  1OPL A;  4P9Z A;  3PFV A;  1RPY A;  2EYY A;  2LQN A;  2GSB A;  1A1C A;  2EYV A;  2C0I A;  1R1P A;  1HCS B;  1FHS A;  2YSX A;  2LNX A;  1O41 A;  4K45 A;  3VS5 A;  1BLJ A;  3EAZ A;  1X27 A;  2RVF A;  3VRQ A;  1SPR A;  2OQ1 A;  2FCI A;  1Y57 A;  2DX0 A;  1LCK A;  1JWO A;  1QG1 E;  2KK6 A;  4EY0 A;  1CSZ A;  2L4K A;  2ROR A;  2CR4 A;  2DM0 A;  1O46 A;  3S9K A;  2K7A B;  5IBM A;  4GWF A;  2PLD A;  1O49 A;  5BO4 A;  3VS0 A;  3OB1 B;  4NWF A;  4EIH A;  3HHM B;  4LUD A;  4OHD A;  2OZO A;  1O4K A;  1YVH A;  1FU5 A;  3CD3 A;  2EO3 A;  1RQQ C;  1X0N A;  3IMD A;  3C7I A;  1TZE E;  2Y1M A;  1YVL A;  3VRZ A;  1CWD L;  1O44 A;  4DGX A;  2MK2 A;  3T04 A;  2EKX A;  3GQI B;  4XZ0 A;  2AOB A;  4K44 A;  4K11 A;  1LUI A;  1BLK A;  4XZ1 A;  2XP1 A;  3VRN A;  3OB2 B;  3VRP A;  1NZV A;  1P13 A;  2C9W A;  4K2R A;  2H8H A;  1BHH A;  1BG1 A;  1M27 A;  1AOT F;  1NZL A;  2IUH A;  1O4I A;  4OHE A;  1SPS A;  1BKL A;  3BKB A;  1LKK A;  3VS4 A;  1AYB A;  1AOU F;  1OO3 A;  2HDX A;  1BHH B;  1O4H A;  3N8M A;  5I6V A;  3IMJ A;  1BFI A;  4JEG A;  1PIC A;  3UF4 A;  2EOB A;  2PTK A;  1JYQ A;  5IBS A;  2RSY A;  4ROJ A;  2C0O A;  2SRC A;  3TL0 A;  3WA4 A;  2AUG A;  4JE4 A;  1GHU A;  2EU0 A;  1O4Q A;  1O42 A;  3OVE A;  2HMH A;  3PJP A;  1KA7 A;  3KFJ A;  2CIA A;  5EEQ A;  1O4M A;  2ETZ A;  3GXX A;  3US4 A;  3MXY A;  4F5B A;  1FU6 A;  1O4R A;  4P9V A;  1LCJ A;  1AD5 A;  1F2F A;  4NWG A;  2L6K A;  1MW4 A;  1IJR A;  4M4Z A;  3TKZ A;  2LNW A;  3N7Y A;  1R1Q A;  2PLE A;  1O4B A;  2FO0 A;  5EEL A;  1A81 A;  1AYA A;  5HKZ A;  5DC4 A;  3CBL A;  1SKJ A;  5GJI A;  2EO6 A;  2LQW A;  1O4F A;  2CI9 A;  2EYZ A;  3ZNI A;  2MRJ A;  4A4B A;  4E93 A;  1A08 A;  5CDW A;  4F59 A;  2CS0 A;  1Y1U A;  2B3O A;  4FBN A;  1JYU A;  2K79 B;  2PNB A;  1ZFP E;  4F5A A;  1O4J A;  1MIL A;  1O45 A;  4E68 A;  3VRO A;  4TZI A;  4X6S A;  3BUW B;  3CXL A;  2MRK A;  1LUN A;  1O4N A;  3S8L A;  5DC9 A;  1CSY A;  1O4L A;  4GL9 E;  1SHA A;  3PQZ A;  2ABL A;  3UYO A;  3BUM B;  3VS7 A;  1OPK A;  1SHD A;  1CWE A;  3GXW A;  2YU7 A;  2LCT A;  1O4G A;  4OHI A;  5AXI A;  5DC0 B;  3MAZ A;  3S8O A;  2VIF A;  1SHB A;  4L1B B;  3OP0 A;  3VRR A;  1BHF A;  2C0T A;  1M61 A;  1FYR A;  1D4W A;  5HKW A;  2L3T A;  5KAZ A;  2GE9 A;  3IN7 A;  1G83 A;  3VS1 A;  4OHL A;  1O43 A;  1UUR A;  3CWG A;  2H5K A;  1WQU A;  4U17 A;  2KNO A;  2JYQ A;  1KC2 A;  5EHP A;  1LUM A;  2DLZ A;  2SHP A;  3QWX X;  4WWQ A;  2PNA A;  3EAC A;  1UUS A;  5J3X A;  1A07 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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