4L1BB

Crystal structure of p110alpha complexed with nish2 of p85alpha
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
277
structure length
277
Chain Sequence
MNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
pubmed doi rcsb
molecule tags Signaling protein/transferase/inhibitor
source organism Homo sapiens
molecule keywords Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub
total genus 104
structure length 277
sequence length 277
ec nomenclature
pdb deposition date 2013-06-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00017 SH2 SH2 domain
B PF16454 PI3K_P85_iSH2 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4l1bB01
2RSYA 3M7FA 1O41A 2MRKA 1JWOA 3BUMB 4U1PA 1FYRA 3NHNA 3TKZA 4F59A 5DC9A 2KNOA 1A1EA 1Y57A 1KA6A 4K45A 2EO3A 1LUMA 3VRNA 4P9ZA 3BKBA 2EKXA 2HMHA 1SHBA 2HCKA 5EHRA 1SPRA 3OP0A 4EY0A 1O4GA 3N7YA 2EYZA 1BLJA 4K44A 2IUIA 1NZLA 5DF6A 1X6CA 2IZVA 2SRCA 1RJAA 1Y1UA 5AULA 1SKJA 3N84A 1TCEA 1AYCA 5DC0B 2DCRA 2DM0A 4EIHA 4XZ0A 5I6VA 5AXIA 2GSBA 5D0JA 1Z3KA 2VIFA 2MRJA 1R1SA 2GE9A 1BM2A 2ABLA 4NWGA 3S8NA 2RORA 1M27A 1JYRA 2Y1MA 1IS0A 1LCKA 1AOUF 1MILA 4XZ1A 1O4HA 3UYOA 2PNAA 3PS5A 4OHEA 3KFJA 3BUNB 4F5BA 1AB2A 4FL2A 2L6KA 1AD5A 4E68A 3VRZA 1BG1A 4FBNA 2MC1A 2EYYA 1QADA 1BKLA 3VRQA 1O4JA 3VRYA 2IUGA 1OO4A 4A4BA 1RPYA 3QWYA 1OO3A 5EELA 1A07A 3VS7A 1FU6A 1A1CA 3T04A 2BBUA 2C0IA 1LKLA 4FL3A 3S9KA 3BUOB 1AOTF 2H5KA 2LNXA 3VS6A 1UUSA 4U17A 1IJRA 2CI9A 1BKMA 3IN7A 1JU5A 1O4RA 1GHUA 1BHHA 2YU7A 2EYVA 4K2RA 1O44A 1BF5A 1TZEE 1OPKA 2OZOA 1BFIA 2AOBA 2RMXA 3BUWB 3GXXA 3S8LA 2EU0A 3PSJA 5HKZA 1D4WA 5EEQA 5GJHA 4H34A 4LUEA 2K7AB 2YSXA 1BHHB 3GXWA 4OHDA 1FMKA 2CR4A 1GRIA 1LUNA 2JYQA 3VS2A 2OQ1A 1CSYA 5EG3B 2ETZA 2PNBA 2PLDA 1QCFA 1X27A 2ECDA 4JE4A 3EAZA 1P13A 5HKWA 1O4EA 5HKYA 1O4FA 4GPLB 1LCJA 1SHAA 1O4KA 1CJ1A 3C7IA 3VRPA 1M61A 2DVJA 1O4IA 2K79B 4NWFA 1MW4A 2EL8A 1KA7A 2DLZA 3EACA 1O4QA 5DC4A 3CXLA 4OHHA 2CI8A 1LUIA 2FCIA 2Y3AB 2MQIA 2DX0A 1FBZA 1F2FA 1O4OA 4LUDA 3OB2B 2C0OA 1A08A 2PTKA 1CWEA 2C0TA 3OB1B 2L3TA 2PLEA 2HDVA 4F5AA 1FBVA 3K2MA 4H1OA 4D8KA 1B47A 4X6SA 1AYDA 2HUWA 1NZVA 1UURA 2C9WA 2LQNA 2QMSA 1PICA 2RVFA 3VS0A 1BLKA 1JYQA 1LUKA 4JGHA 5KAZA 2H46E 4TZIA 1RQQC 3MXCA 3PLFB 1HCSB 3PJPA 3CD3A 3HIZB 1ZFPE 4GL9E 3ZNIA 3QWXX 2SHPA 1NRVA 1BFJA 2KK6A 1O49A 4M4ZA 2EOBA 2CS0A 1KSWA 3US4A 2LNWA 1XA6A 3IMJA 3VGOA 1O4CA 2Y1NA 1O42A 3N8MA 5GJIA 3MAZA 3CWGA 4WWQA 1K9AA 2HDXA 2L4KA 1OPLA 4L1BB 3HCKA 5IBSA 2AOAA 3PQZA 5BO4A 4JEGA 4DGXA 1O4MA 4DGPA 1O4DA 1R1PA 5IBMA 1D1ZA 1H9OA 1YVHA 2LCTA 3S8OA 1O48A 3TL0A 2MK2A 3UF4A 1D4TA 1F1WA 5CDWA 1A1BA 3MXYA 4A4CA 3VROA 1WQUA 3OVEA 1HCTB 4ROJA 1O45A 2CBLA 1X0NA 3IMDA 4GWFA 2H8HA 3VRRA 1QG1E 1YVLA 3BUXB 1FHSA 1O4LA 3OV1A 1CSZA 5EHPA 1O4BA 2EO6A 4P9VA 3CBLA 1O47A 4E93A 1I3ZA 2AUGA 3WA4A 2CRHA 5J3XA 1G83A 1KC2A 1SHDA 1CWDL 1SPSA 4OHIA 1R1QA 4QSYA 1BHFA 1O4AA 1A81A 2B3OA 1O46A 1JYUA 1AYAA 3GQIB 1O4PA 1LKKA 1AYBA 3HHMB 2XP1A 2FO0A 1O4NA 2IUHA 3PFVA 2LQWA 3VS1A 3PSKA 1A1AA 2DLYA 1FU5A 1BMBA 3VS5A 4K11A 2CIAA 3IN8A 4OHLA 3VS4A 3VS3A 1O43A 1A09A
chains in the Genus database with same CATH superfamily
2RSYA 3M7FA 1O41A 2MRKA 1JWOA 3BUMB 4U1PA 1FYRA 3NHNA 3TKZA 4F59A 5DC9A 2KNOA 1A1EA 1Y57A 1KA6A 4K45A 2EO3A 1LUMA 3VRNA 4P9ZA 3BKBA 2EKXA 2HMHA 1SHBA 2HCKA 5EHRA 1SPRA 3OP0A 4EY0A 1O4GA 3N7YA 2EYZA 1BLJA 4K44A 2IUIA 1NZLA 5DF6A 1X6CA 2IZVA 2SRCA 1RJAA 1Y1UA 5AULA 1SKJA 3N84A 1TCEA 1AYCA 5DC0B 2DCRA 2DM0A 4EIHA 4XZ0A 5I6VA 5AXIA 2GSBA 5D0JA 1Z3KA 2VIFA 2MRJA 1R1SA 2GE9A 3LYVA 1BM2A 2ABLA 4NWGA 3S8NA 2RORA 1M27A 1JYRA 2Y1MA 1IS0A 1LCKA 1AOUF 1MILA 4XZ1A 1O4HA 3UYOA 2PNAA 3PS5A 4OHEA 3KFJA 3BUNB 4F5BA 1AB2A 4FL2A 2L6KA 1AD5A 4E68A 3VRZA 1BG1A 4FBNA 2MC1A 2EYYA 1QADA 1BKLA 3VRQA 1O4JA 3VRYA 2IUGA 1OO4A 4A4BA 1RPYA 3QWYA 1OO3A 5EELA 1A07A 3VS7A 1FU6A 1A1CA 3T04A 2BBUA 2C0IA 1LKLA 4FL3A 3S9KA 3BUOB 1AOTF 2H5KA 2LNXA 3VS6A 1UUSA 4U17A 1IJRA 2CI9A 1BKMA 3IN7A 1JU5A 1O4RA 1GHUA 1BHHA 2YU7A 2EYVA 4K2RA 1O44A 1BF5A 1TZEE 1OPKA 2OZOA 1BFIA 2AOBA 2RMXA 3BUWB 3GXXA 3S8LA 2EU0A 3PSJA 5HKZA 1D4WA 5EEQA 5GJHA 4H34A 4LUEA 2K7AB 2YSXA 1BHHB 3GXWA 4OHDA 1FMKA 2CR4A 1GRIA 1LUNA 2JYQA 3VS2A 2OQ1A 1CSYA 5EG3B 2ETZA 2PNBA 2PLDA 1QCFA 1X27A 2ECDA 4JE4A 3EAZA 1P13A 5HKWA 1O4EA 5HKYA 1O4FA 4GPLB 1LCJA 1SHAA 1O4KA 1CJ1A 3C7IA 3VRPA 1M61A 2DVJA 1O4IA 2K79B 4NWFA 1MW4A 2EL8A 1KA7A 2DLZA 3EACA 1O4QA 5DC4A 3CXLA 4OHHA 2CI8A 1LUIA 2FCIA 2Y3AB 2MQIA 2DX0A 1FBZA 1F2FA 1O4OA 4LUDA 3OB2B 2C0OA 1A08A 2PTKA 1CWEA 2C0TA 3OB1B 2L3TA 2PLEA 2HDVA 4F5AA 2KGYA 1FBVA 3K2MA 4H1OA 4D8KA 1B47A 4X6SA 1AYDA 2HUWA 1NZVA 1UURA 2C9WA 2LQNA 2QMSA 1PICA 2RVFA 3VS0A 1BLKA 1JYQA 1LUKA 4JGHA 2LRAA 5KAZA 2H46E 4TZIA 1RQQC 3MXCA 3PLFB 1HCSB 3K2TA 3PJPA 3CD3A 3HIZB 1ZFPE 4GL9E 3ZNIA 3QWXX 2SHPA 1NRVA 1BFJA 2KK6A 1O49A 4M4ZA 2EOBA 2CS0A 1KSWA 3US4A 2LNWA 1XA6A 3IMJA 3VGOA 1O4CA 2Y1NA 1O42A 3N8MA 5GJIA 3MAZA 3CWGA 4WWQA 1K9AA 2HDXA 2L4KA 1OPLA 4L1BB 3HCKA 5IBSA 2AOAA 3PQZA 5BO4A 4JEGA 4DGXA 1O4MA 4DGPA 1O4DA 1R1PA 5IBMA 1D1ZA 1H9OA 1YVHA 2LCTA 3S8OA 1O48A 3TL0A 2MK2A 3UF4A 1D4TA 1F1WA 5CDWA 1A1BA 3MXYA 4A4CA 3VROA 1WQUA 3OVEA 1HCTB 4ROJA 1O45A 2CBLA 1X0NA 3IMDA 4GWFA 2H8HA 3VRRA 1QG1E 1YVLA 3BUXB 1FHSA 1O4LA 3OV1A 1CSZA 5EHPA 1O4BA 2EO6A 4P9VA 3CBLA 1O47A 4E93A 1I3ZA 2AUGA 3WA4A 2CRHA 5J3XA 1G83A 1KC2A 1SHDA 1CWDL 1SPSA 4OHIA 1R1QA 4QSYA 1BHFA 1O4AA 1A81A 2B3OA 1O46A 1JYUA 1AYAA 3GQIB 1O4PA 1LKKA 1AYBA 3HHMB 2XP1A 2FO0A 1O4NA 2IUHA 3PFVA 2LQWA 3VS1A 3PSKA 1A1AA 2DLYA 1FU5A 1BMBA 3VS5A 4K11A 2CIAA 3IN8A 4OHLA 3VS4A 3VS3A 1O43A 1A09A
chains in the Genus database with same CATH topology
2RSYA 3M7FA 1O41A 2MRKA 1JWOA 3BUMB 4U1PA 1FYRA 3NHNA 3TKZA 4F59A 5DC9A 2KNOA 1A1EA 1Y57A 1KA6A 4K45A 2EO3A 1LUMA 3VRNA 4P9ZA 3BKBA 2EKXA 2HMHA 1SHBA 2HCKA 5EHRA 1SPRA 3OP0A 4EY0A 1O4GA 3N7YA 2EYZA 1BLJA 4K44A 2IUIA 1NZLA 5DF6A 1X6CA 2IZVA 2SRCA 1RJAA 1Y1UA 5AULA 1SKJA 3N84A 1TCEA 1AYCA 5DC0B 2DCRA 2DM0A 4EIHA 4XZ0A 5I6VA 5AXIA 2GSBA 5D0JA 1Z3KA 2VIFA 2MRJA 1R1SA 2GE9A 1BM2A 2ABLA 4NWGA 3S8NA 2RORA 1M27A 1JYRA 2Y1MA 1IS0A 1LCKA 1AOUF 1MILA 4XZ1A 1O4HA 3UYOA 2PNAA 3PS5A 4OHEA 3KFJA 3BUNB 4F5BA 1AB2A 4FL2A 2L6KA 1AD5A 4E68A 3VRZA 1BG1A 4FBNA 2MC1A 2EYYA 1QADA 1BKLA 3VRQA 1O4JA 3VRYA 2IUGA 1OO4A 4A4BA 1RPYA 3QWYA 1OO3A 5EELA 1A07A 3VS7A 1FU6A 1A1CA 3T04A 2BBUA 2C0IA 1LKLA 4FL3A 3S9KA 3BUOB 1AOTF 2H5KA 2LNXA 3VS6A 1UUSA 4U17A 1IJRA 2CI9A 1BKMA 3IN7A 1JU5A 1O4RA 1GHUA 1BHHA 2YU7A 2EYVA 4K2RA 1O44A 1BF5A 1TZEE 1OPKA 2OZOA 1BFIA 2AOBA 2RMXA 3BUWB 3GXXA 3S8LA 2EU0A 3PSJA 5HKZA 1D4WA 5EEQA 5GJHA 4H34A 4LUEA 2K7AB 2YSXA 1BHHB 3GXWA 4OHDA 1FMKA 2CR4A 1GRIA 1LUNA 2JYQA 3VS2A 2OQ1A 1CSYA 5EG3B 2ETZA 2PNBA 2PLDA 1QCFA 1X27A 2ECDA 4JE4A 3EAZA 1P13A 5HKWA 1O4EA 5HKYA 1O4FA 4GPLB 1LCJA 1SHAA 1O4KA 1CJ1A 3C7IA 3VRPA 1M61A 2DVJA 1O4IA 2K79B 4NWFA 1MW4A 2EL8A 1KA7A 2DLZA 3EACA 1O4QA 5DC4A 3CXLA 4OHHA 2CI8A 1LUIA 2FCIA 2Y3AB 2MQIA 2DX0A 1FBZA 1F2FA 1O4OA 4LUDA 3OB2B 2C0OA 1A08A 2PTKA 1CWEA 2C0TA 3OB1B 2L3TA 2PLEA 2HDVA 4F5AA 1FBVA 3K2MA 4H1OA 4D8KA 1B47A 4X6SA 1AYDA 2HUWA 1NZVA 1UURA 2C9WA 2LQNA 2QMSA 1PICA 2RVFA 3VS0A 1BLKA 1JYQA 1LUKA 4JGHA 5KAZA 2H46E 4TZIA 1RQQC 3MXCA 3PLFB 1HCSB 3PJPA 3CD3A 3HIZB 1ZFPE 4GL9E 3ZNIA 3QWXX 2SHPA 1NRVA 1BFJA 2KK6A 1O49A 4M4ZA 2EOBA 2CS0A 1KSWA 3US4A 2LNWA 1XA6A 3IMJA 3VGOA 1O4CA 2Y1NA 1O42A 3N8MA 5GJIA 3MAZA 3CWGA 4WWQA 1K9AA 2HDXA 2L4KA 1OPLA 4L1BB 3HCKA 5IBSA 2AOAA 3PQZA 5BO4A 4JEGA 4DGXA 1O4MA 4DGPA 1O4DA 1R1PA 5IBMA 1D1ZA 1H9OA 1YVHA 2LCTA 3S8OA 1O48A 3TL0A 2MK2A 3UF4A 1D4TA 1F1WA 5CDWA 1A1BA 3MXYA 4A4CA 3VROA 1WQUA 3OVEA 1HCTB 4ROJA 1O45A 2CBLA 1X0NA 3IMDA 4GWFA 2H8HA 3VRRA 1QG1E 1YVLA 3BUXB 1FHSA 1O4LA 3OV1A 1CSZA 5EHPA 1O4BA 2EO6A 4P9VA 3CBLA 1O47A 4E93A 1I3ZA 2AUGA 3WA4A 2CRHA 5J3XA 1G83A 1KC2A 1SHDA 1CWDL 1SPSA 4OHIA 1R1QA 4QSYA 1BHFA 1O4AA 1A81A 2B3OA 1O46A 1JYUA 1AYAA 3GQIB 1O4PA 1LKKA 1AYBA 3HHMB 2XP1A 2FO0A 1O4NA 2IUHA 3PFVA 2LQWA 3VS1A 3PSKA 1A1AA 2DLYA 1FU5A 1BMBA 3VS5A 4K11A 2CIAA 3IN8A 4OHLA 3VS4A 3VS3A 1O43A 1A09A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RSY A;  3M7F A;  1O41 A;  2MRK A;  1JWO A;  3BUM B;  4U1P A;  1FYR A;  3NHN A;  3TKZ A;  4F59 A;  5DC9 A;  2KNO A;  1A1E A;  1Y57 A;  1KA6 A;  4K45 A;  2EO3 A;  1LUM A;  3VRN A;  4P9Z A;  3BKB A;  2EKX A;  2HMH A;  1SHB A;  2HCK A;  5EHR A;  1SPR A;  3OP0 A;  4EY0 A;  1O4G A;  3N7Y A;  2EYZ A;  1BLJ A;  4K44 A;  2IUI A;  1NZL A;  5DF6 A;  1X6C A;  2IZV A;  2SRC A;  1RJA A;  1Y1U A;  5AUL A;  1SKJ A;  3N84 A;  1TCE A;  1AYC A;  5DC0 B;  2DCR A;  2DM0 A;  4EIH A;  4XZ0 A;  5I6V A;  5AXI A;  2GSB A;  5D0J A;  1Z3K A;  2VIF A;  2MRJ A;  1R1S A;  2GE9 A;  1BM2 A;  2ABL A;  4NWG A;  3S8N A;  2ROR A;  1M27 A;  1JYR A;  2Y1M A;  1IS0 A;  1LCK A;  1AOU F;  1MIL A;  4XZ1 A;  1O4H A;  3UYO A;  2PNA A;  3PS5 A;  4OHE A;  3KFJ A;  3BUN B;  4F5B A;  1AB2 A;  4FL2 A;  2L6K A;  1AD5 A;  4E68 A;  3VRZ A;  1BG1 A;  4FBN A;  2MC1 A;  2EYY A;  1QAD A;  1BKL A;  3VRQ A;  1O4J A;  3VRY A;  2IUG A;  1OO4 A;  4A4B A;  1RPY A;  3QWY A;  1OO3 A;  5EEL A;  1A07 A;  3VS7 A;  1FU6 A;  1A1C A;  3T04 A;  2BBU A;  2C0I A;  1LKL A;  4FL3 A;  3S9K A;  3BUO B;  1AOT F;  2H5K A;  2LNX A;  3VS6 A;  1UUS A;  4U17 A;  1IJR A;  2CI9 A;  1BKM A;  3IN7 A;  1JU5 A;  1O4R A;  1GHU A;  1BHH A;  2YU7 A;  2EYV A;  4K2R A;  1O44 A;  1BF5 A;  1TZE E;  1OPK A;  2OZO A;  1BFI A;  2AOB A;  2RMX A;  3BUW B;  3GXX A;  3S8L A;  2EU0 A;  3PSJ A;  5HKZ A;  1D4W A;  5EEQ A;  5GJH A;  4H34 A;  4LUE A;  2K7A B;  2YSX A;  1BHH B;  3GXW A;  4OHD A;  1FMK A;  2CR4 A;  1GRI A;  1LUN A;  2JYQ A;  3VS2 A;  2OQ1 A;  1CSY A;  5EG3 B;  2ETZ A;  2PNB A;  2PLD A;  1QCF A;  1X27 A;  2ECD A;  4JE4 A;  3EAZ A;  1P13 A;  5HKW A;  1O4E A;  5HKY A;  1O4F A;  4GPL B;  1LCJ A;  1SHA A;  1O4K A;  1CJ1 A;  3C7I A;  3VRP A;  1M61 A;  2DVJ A;  1O4I A;  2K79 B;  4NWF A;  1MW4 A;  2EL8 A;  1KA7 A;  2DLZ A;  3EAC A;  1O4Q A;  5DC4 A;  3CXL A;  4OHH A;  2CI8 A;  1LUI A;  2FCI A;  2Y3A B;  2MQI A;  2DX0 A;  1FBZ A;  1F2F A;  1O4O A;  4LUD A;  3OB2 B;  2C0O A;  1A08 A;  2PTK A;  1CWE A;  2C0T A;  3OB1 B;  2L3T A;  2PLE A;  2HDV A;  4F5A A;  1FBV A;  3K2M A;  4H1O A;  4D8K A;  1B47 A;  4X6S A;  1AYD A;  2HUW A;  1NZV A;  1UUR A;  2C9W A;  2LQN A;  2QMS A;  1PIC A;  2RVF A;  3VS0 A;  1BLK A;  1JYQ A;  1LUK A;  4JGH A;  5KAZ A;  2H46 E;  4TZI A;  1RQQ C;  3MXC A;  3PLF B;  1HCS B;  3PJP A;  3CD3 A;  3HIZ B;  1ZFP E;  4GL9 E;  3ZNI A;  3QWX X;  2SHP A;  1NRV A;  1BFJ A;  2KK6 A;  1O49 A;  4M4Z A;  2EOB A;  2CS0 A;  1KSW A;  3US4 A;  2LNW A;  1XA6 A;  3IMJ A;  3VGO A;  1O4C A;  2Y1N A;  1O42 A;  3N8M A;  5GJI A;  3MAZ A;  3CWG A;  4WWQ A;  1K9A A;  2HDX A;  2L4K A;  1OPL A;  4L1B B;  3HCK A;  5IBS A;  2AOA A;  3PQZ A;  5BO4 A;  4JEG A;  4DGX A;  1O4M A;  4DGP A;  1O4D A;  1R1P A;  5IBM A;  1D1Z A;  1H9O A;  1YVH A;  2LCT A;  3S8O A;  1O48 A;  3TL0 A;  2MK2 A;  3UF4 A;  1D4T A;  1F1W A;  5CDW A;  1A1B A;  3MXY A;  4A4C A;  3VRO A;  1WQU A;  3OVE A;  1HCT B;  4ROJ A;  1O45 A;  2CBL A;  1X0N A;  3IMD A;  4GWF A;  2H8H A;  3VRR A;  1QG1 E;  1YVL A;  3BUX B;  1FHS A;  1O4L A;  3OV1 A;  1CSZ A;  5EHP A;  1O4B A;  2EO6 A;  4P9V A;  3CBL A;  1O47 A;  4E93 A;  1I3Z A;  2AUG A;  3WA4 A;  2CRH A;  5J3X A;  1G83 A;  1KC2 A;  1SHD A;  1CWD L;  1SPS A;  4OHI A;  1R1Q A;  4QSY A;  1BHF A;  1O4A A;  1A81 A;  2B3O A;  1O46 A;  1JYU A;  1AYA A;  3GQI B;  1O4P A;  1LKK A;  1AYB A;  3HHM B;  2XP1 A;  2FO0 A;  1O4N A;  2IUH A;  3PFV A;  2LQW A;  3VS1 A;  3PSK A;  1A1A A;  2DLY A;  1FU5 A;  1BMB A;  3VS5 A;  4K11 A;  2CIA A;  3IN8 A;  4OHL A;  3VS4 A;  3VS3 A;  1O43 A;  1A09 A; 
#chains in the Genus database with same CATH topology
 2RSY A;  3M7F A;  1O41 A;  2MRK A;  1JWO A;  3BUM B;  4U1P A;  1FYR A;  3NHN A;  3TKZ A;  4F59 A;  5DC9 A;  2KNO A;  1A1E A;  1Y57 A;  1KA6 A;  4K45 A;  2EO3 A;  1LUM A;  3VRN A;  4P9Z A;  3BKB A;  2EKX A;  2HMH A;  1SHB A;  2HCK A;  5EHR A;  1SPR A;  3OP0 A;  4EY0 A;  1O4G A;  3N7Y A;  2EYZ A;  1BLJ A;  4K44 A;  2IUI A;  1NZL A;  5DF6 A;  1X6C A;  2IZV A;  2SRC A;  1RJA A;  1Y1U A;  5AUL A;  1SKJ A;  3N84 A;  1TCE A;  1AYC A;  5DC0 B;  2DCR A;  2DM0 A;  4EIH A;  4XZ0 A;  5I6V A;  5AXI A;  2GSB A;  5D0J A;  1Z3K A;  2VIF A;  2MRJ A;  1R1S A;  2GE9 A;  3LYV A;  1BM2 A;  2ABL A;  4NWG A;  3S8N A;  2ROR A;  1M27 A;  1JYR A;  2Y1M A;  1IS0 A;  1LCK A;  1AOU F;  1MIL A;  4XZ1 A;  1O4H A;  3UYO A;  2PNA A;  3PS5 A;  4OHE A;  3KFJ A;  3BUN B;  4F5B A;  1AB2 A;  4FL2 A;  2L6K A;  1AD5 A;  4E68 A;  3VRZ A;  1BG1 A;  4FBN A;  2MC1 A;  2EYY A;  1QAD A;  1BKL A;  3VRQ A;  1O4J A;  3VRY A;  2IUG A;  1OO4 A;  4A4B A;  1RPY A;  3QWY A;  1OO3 A;  5EEL A;  1A07 A;  3VS7 A;  1FU6 A;  1A1C A;  3T04 A;  2BBU A;  2C0I A;  1LKL A;  4FL3 A;  3S9K A;  3BUO B;  1AOT F;  2H5K A;  2LNX A;  3VS6 A;  1UUS A;  4U17 A;  1IJR A;  2CI9 A;  1BKM A;  3IN7 A;  1JU5 A;  1O4R A;  1GHU A;  1BHH A;  2YU7 A;  2EYV A;  4K2R A;  1O44 A;  1BF5 A;  1TZE E;  1OPK A;  2OZO A;  1BFI A;  2AOB A;  2RMX A;  3BUW B;  3GXX A;  3S8L A;  2EU0 A;  3PSJ A;  5HKZ A;  1D4W A;  5EEQ A;  5GJH A;  4H34 A;  4LUE A;  2K7A B;  2YSX A;  1BHH B;  3GXW A;  4OHD A;  1FMK A;  2CR4 A;  1GRI A;  1LUN A;  2JYQ A;  3VS2 A;  2OQ1 A;  1CSY A;  5EG3 B;  2ETZ A;  2PNB A;  2PLD A;  1QCF A;  1X27 A;  2ECD A;  4JE4 A;  3EAZ A;  1P13 A;  5HKW A;  1O4E A;  5HKY A;  1O4F A;  4GPL B;  1LCJ A;  1SHA A;  1O4K A;  1CJ1 A;  3C7I A;  3VRP A;  1M61 A;  2DVJ A;  1O4I A;  2K79 B;  4NWF A;  1MW4 A;  2EL8 A;  1KA7 A;  2DLZ A;  3EAC A;  1O4Q A;  5DC4 A;  3CXL A;  4OHH A;  2CI8 A;  1LUI A;  2FCI A;  2Y3A B;  2MQI A;  2DX0 A;  1FBZ A;  1F2F A;  1O4O A;  4LUD A;  3OB2 B;  2C0O A;  1A08 A;  2PTK A;  1CWE A;  2C0T A;  3OB1 B;  2L3T A;  2PLE A;  2HDV A;  4F5A A;  2KGY A;  1FBV A;  3K2M A;  4H1O A;  4D8K A;  1B47 A;  4X6S A;  1AYD A;  2HUW A;  1NZV A;  1UUR A;  2C9W A;  2LQN A;  2QMS A;  1PIC A;  2RVF A;  3VS0 A;  1BLK A;  1JYQ A;  1LUK A;  4JGH A;  2LRA A;  5KAZ A;  2H46 E;  4TZI A;  1RQQ C;  3MXC A;  3PLF B;  1HCS B;  3K2T A;  3PJP A;  3CD3 A;  3HIZ B;  1ZFP E;  4GL9 E;  3ZNI A;  3QWX X;  2SHP A;  1NRV A;  1BFJ A;  2KK6 A;  1O49 A;  4M4Z A;  2EOB A;  2CS0 A;  1KSW A;  3US4 A;  2LNW A;  1XA6 A;  3IMJ A;  3VGO A;  1O4C A;  2Y1N A;  1O42 A;  3N8M A;  5GJI A;  3MAZ A;  3CWG A;  4WWQ A;  1K9A A;  2HDX A;  2L4K A;  1OPL A;  4L1B B;  3HCK A;  5IBS A;  2AOA A;  3PQZ A;  5BO4 A;  4JEG A;  4DGX A;  1O4M A;  4DGP A;  1O4D A;  1R1P A;  5IBM A;  1D1Z A;  1H9O A;  1YVH A;  2LCT A;  3S8O A;  1O48 A;  3TL0 A;  2MK2 A;  3UF4 A;  1D4T A;  1F1W A;  5CDW A;  1A1B A;  3MXY A;  4A4C A;  3VRO A;  1WQU A;  3OVE A;  1HCT B;  4ROJ A;  1O45 A;  2CBL A;  1X0N A;  3IMD A;  4GWF A;  2H8H A;  3VRR A;  1QG1 E;  1YVL A;  3BUX B;  1FHS A;  1O4L A;  3OV1 A;  1CSZ A;  5EHP A;  1O4B A;  2EO6 A;  4P9V A;  3CBL A;  1O47 A;  4E93 A;  1I3Z A;  2AUG A;  3WA4 A;  2CRH A;  5J3X A;  1G83 A;  1KC2 A;  1SHD A;  1CWD L;  1SPS A;  4OHI A;  1R1Q A;  4QSY A;  1BHF A;  1O4A A;  1A81 A;  2B3O A;  1O46 A;  1JYU A;  1AYA A;  3GQI B;  1O4P A;  1LKK A;  1AYB A;  3HHM B;  2XP1 A;  2FO0 A;  1O4N A;  2IUH A;  3PFV A;  2LQW A;  3VS1 A;  3PSK A;  1A1A A;  2DLY A;  1FU5 A;  1BMB A;  3VS5 A;  4K11 A;  2CIA A;  3IN8 A;  4OHL A;  3VS4 A;  3VS3 A;  1O43 A;  1A09 A; 
#chains in the Genus database with same CATH homology
 2RSY A;  3M7F A;  1O41 A;  2MRK A;  1JWO A;  3BUM B;  4U1P A;  1FYR A;  3NHN A;  3TKZ A;  4F59 A;  5DC9 A;  2KNO A;  1A1E A;  1Y57 A;  1KA6 A;  4K45 A;  2EO3 A;  1LUM A;  3VRN A;  4P9Z A;  3BKB A;  2EKX A;  2HMH A;  1SHB A;  2HCK A;  5EHR A;  1SPR A;  3OP0 A;  4EY0 A;  1O4G A;  3N7Y A;  2EYZ A;  1BLJ A;  4K44 A;  2IUI A;  1NZL A;  5DF6 A;  1X6C A;  2IZV A;  2SRC A;  1RJA A;  1Y1U A;  5AUL A;  1SKJ A;  3N84 A;  1TCE A;  1AYC A;  5DC0 B;  2DCR A;  2DM0 A;  4EIH A;  4XZ0 A;  5I6V A;  5AXI A;  2GSB A;  5D0J A;  1Z3K A;  2VIF A;  2MRJ A;  1R1S A;  2GE9 A;  1BM2 A;  2ABL A;  4NWG A;  3S8N A;  2ROR A;  1M27 A;  1JYR A;  2Y1M A;  1IS0 A;  1LCK A;  1AOU F;  1MIL A;  4XZ1 A;  1O4H A;  3UYO A;  2PNA A;  3PS5 A;  4OHE A;  3KFJ A;  3BUN B;  4F5B A;  1AB2 A;  4FL2 A;  2L6K A;  1AD5 A;  4E68 A;  3VRZ A;  1BG1 A;  4FBN A;  2MC1 A;  2EYY A;  1QAD A;  1BKL A;  3VRQ A;  1O4J A;  3VRY A;  2IUG A;  1OO4 A;  4A4B A;  1RPY A;  3QWY A;  1OO3 A;  5EEL A;  1A07 A;  3VS7 A;  1FU6 A;  1A1C A;  3T04 A;  2BBU A;  2C0I A;  1LKL A;  4FL3 A;  3S9K A;  3BUO B;  1AOT F;  2H5K A;  2LNX A;  3VS6 A;  1UUS A;  4U17 A;  1IJR A;  2CI9 A;  1BKM A;  3IN7 A;  1JU5 A;  1O4R A;  1GHU A;  1BHH A;  2YU7 A;  2EYV A;  4K2R A;  1O44 A;  1BF5 A;  1TZE E;  1OPK A;  2OZO A;  1BFI A;  2AOB A;  2RMX A;  3BUW B;  3GXX A;  3S8L A;  2EU0 A;  3PSJ A;  5HKZ A;  1D4W A;  5EEQ A;  5GJH A;  4H34 A;  4LUE A;  2K7A B;  2YSX A;  1BHH B;  3GXW A;  4OHD A;  1FMK A;  2CR4 A;  1GRI A;  1LUN A;  2JYQ A;  3VS2 A;  2OQ1 A;  1CSY A;  5EG3 B;  2ETZ A;  2PNB A;  2PLD A;  1QCF A;  1X27 A;  2ECD A;  4JE4 A;  3EAZ A;  1P13 A;  5HKW A;  1O4E A;  5HKY A;  1O4F A;  4GPL B;  1LCJ A;  1SHA A;  1O4K A;  1CJ1 A;  3C7I A;  3VRP A;  1M61 A;  2DVJ A;  1O4I A;  2K79 B;  4NWF A;  1MW4 A;  2EL8 A;  1KA7 A;  2DLZ A;  3EAC A;  1O4Q A;  5DC4 A;  3CXL A;  4OHH A;  2CI8 A;  1LUI A;  2FCI A;  2Y3A B;  2MQI A;  2DX0 A;  1FBZ A;  1F2F A;  1O4O A;  4LUD A;  3OB2 B;  2C0O A;  1A08 A;  2PTK A;  1CWE A;  2C0T A;  3OB1 B;  2L3T A;  2PLE A;  2HDV A;  4F5A A;  1FBV A;  3K2M A;  4H1O A;  4D8K A;  1B47 A;  4X6S A;  1AYD A;  2HUW A;  1NZV A;  1UUR A;  2C9W A;  2LQN A;  2QMS A;  1PIC A;  2RVF A;  3VS0 A;  1BLK A;  1JYQ A;  1LUK A;  4JGH A;  5KAZ A;  2H46 E;  4TZI A;  1RQQ C;  3MXC A;  3PLF B;  1HCS B;  3PJP A;  3CD3 A;  3HIZ B;  1ZFP E;  4GL9 E;  3ZNI A;  3QWX X;  2SHP A;  1NRV A;  1BFJ A;  2KK6 A;  1O49 A;  4M4Z A;  2EOB A;  2CS0 A;  1KSW A;  3US4 A;  2LNW A;  1XA6 A;  3IMJ A;  3VGO A;  1O4C A;  2Y1N A;  1O42 A;  3N8M A;  5GJI A;  3MAZ A;  3CWG A;  4WWQ A;  1K9A A;  2HDX A;  2L4K A;  1OPL A;  4L1B B;  3HCK A;  5IBS A;  2AOA A;  3PQZ A;  5BO4 A;  4JEG A;  4DGX A;  1O4M A;  4DGP A;  1O4D A;  1R1P A;  5IBM A;  1D1Z A;  1H9O A;  1YVH A;  2LCT A;  3S8O A;  1O48 A;  3TL0 A;  2MK2 A;  3UF4 A;  1D4T A;  1F1W A;  5CDW A;  1A1B A;  3MXY A;  4A4C A;  3VRO A;  1WQU A;  3OVE A;  1HCT B;  4ROJ A;  1O45 A;  2CBL A;  1X0N A;  3IMD A;  4GWF A;  2H8H A;  3VRR A;  1QG1 E;  1YVL A;  3BUX B;  1FHS A;  1O4L A;  3OV1 A;  1CSZ A;  5EHP A;  1O4B A;  2EO6 A;  4P9V A;  3CBL A;  1O47 A;  4E93 A;  1I3Z A;  2AUG A;  3WA4 A;  2CRH A;  5J3X A;  1G83 A;  1KC2 A;  1SHD A;  1CWD L;  1SPS A;  4OHI A;  1R1Q A;  4QSY A;  1BHF A;  1O4A A;  1A81 A;  2B3O A;  1O46 A;  1JYU A;  1AYA A;  3GQI B;  1O4P A;  1LKK A;  1AYB A;  3HHM B;  2XP1 A;  2FO0 A;  1O4N A;  2IUH A;  3PFV A;  2LQW A;  3VS1 A;  3PSK A;  1A1A A;  2DLY A;  1FU5 A;  1BMB A;  3VS5 A;  4K11 A;  2CIA A;  3IN8 A;  4OHL A;  3VS4 A;  3VS3 A;  1O43 A;  1A09 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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