2AOAA

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the grb2 sh2 domain
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
93
structure length
93
Chain Sequence
HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 19
structure length 93
sequence length 93
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-08-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2aoaA00
2JYQA 1LCKA 3VRRA 1SPRA 2IUGA 4X6SA 5J3XA 2IZVA 2PNBA 1O46A 1R1SA 3TKZA 2EKXA 3HIZB 3GXWA 1A1AA 1A08A 2DLYA 2EYYA 5GJIA 2EOBA 1HCSB 2HDXA 1LKLA 1A1EA 5EG3B 2C0OA 2YU7A 1O4LA 3BUNB 3BUXB 2EYZA 2IUHA 2CS0A 1O42A 1LUIA 1O4KA 1BG1A 1O4QA 1X6CA 3VS6A 1BHFA 1LCJA 4WWQA 4H34A 3OV1A 4P9VA 3PS5A 1AYBA 1BKMA 1O41A 2EL8A 5D0JA 1O4NA 3M7FA 1FHSA 2SHPA 3PSJA 1AOTF 4E93A 2EU0A 1O4MA 1P13A 1O47A 1O4IA 2CI9A 1XA6A 5IBMA 1CWEA 4OHEA 2CRHA 3VS0A 2K7AB 4F5AA 3UYOA 2XP1A 4L1BB 1FU5A 1FU6A 5DC0B 4NWFA 1WQUA 1LUMA 1SHBA 2RMXA 1X27A 1JYQA 1NZVA 1SHDA 3OB1B 2QMSA 1AYCA 2PNAA 2C0TA 1NRVA 1O4PA 3IN7A 1B47A 1BFJA 2RORA 3VRYA 3VGOA 2PLDA 2ETZA 5AXIA 3OB2B 2B3OA 1AB2A 2DLZA 5HKZA 2OZOA 2Y1NA 4LUDA 4OHIA 1MW4A 4GWFA 1OPKA 1O43A 3N7YA 5HKYA 2OQ1A 1O4CA 2EYVA 3C7IA 2CIAA 3VS1A 1GRIA 4K11A 4U1PA 3WA4A 2FCIA 1CSYA 1SKJA 1O4BA 1O48A 5CDWA 3US4A 4EIHA 3OVEA 1BF5A 1OPLA 2LNXA 4OHDA 5EHPA 1LKKA 3PFVA 3VS7A 3T04A 5EELA 3CBLA 2AOAA 1AYAA 1FBZA 2CBLA 4NWGA 1YVHA 2HCKA 3BUWB 1MILA 1D1ZA 1R1QA 1AOUF 4FL2A 3CD3A 5DC4A 1F1WA 3VRQA 2L3TA 3UF4A 2LCTA 1GHUA 4U17A 1H9OA 4JGHA 1Y1UA 2DX0A 1O4RA 4A4CA 1LUNA 2KK6A 3IN8A 2YSXA 2CI8A 5EHRA 1BMBA 1O49A 4K44A 1BHHB 2VIFA 3ZNIA 1R1PA 1O4JA 1YVLA 1JYUA 1KA7A 3KFJA 4OHLA 4GPLB 2C0IA 4TZIA 3PSKA 1RJAA 2RSYA 4XZ1A 3MXCA 2GE9A 3VROA 5IBSA 3N84A 3N8MA 3VRNA 3PJPA 4GL9E 4EY0A 1ZFPE 3EACA 3K2MA 2BBUA 2H5KA 5AULA 1FMKA 1PICA 4QSYA 3VS3A 1CSZA 2MK2A 3VS2A 1I3ZA 4A4BA 5BO4A 4JEGA 1O4HA 1FYRA 3MAZA 1LUKA 2MRKA 1O44A 2LNWA 3VS5A 2HMHA 1O4AA 1F2FA 3S9KA 1SHAA 2DVJA 3TL0A 1M27A 2SRCA 1A09A 1RPYA 4XZ0A 1TZEE 1JU5A 2KNOA 2LQWA 4ROJA 1AD5A 4E68A 1A81A 2PLEA 3HHMB 2RVFA 3QWYA 2ABLA 3BKBA 1BHHA 2MRJA 3MXYA 1BLJA 5I6VA 1NZLA 2HUWA 2L6KA 3EAZA 3HCKA 3IMJA 1O4EA 2H46E 3S8NA 2HDVA 2PTKA 1QCFA 1A07A 2FO0A 2MQIA 3PLFB 4K2RA 1KSWA 2EO6A 1JYRA 5GJHA 3PQZA 3VRPA 1RQQC 1QG1E 2MC1A 1Y57A 4FL3A 3S8LA 4K45A 3GQIB 1BM2A 1OO4A 4D8KA 1A1CA 5DC9A 1Z3KA 5DF6A 1SPSA 1X0NA 1OO3A 4DGPA 4FBNA 2IUIA 2C9WA 1TCEA 1FBVA 2AOBA 1D4WA 5KAZA 3CWGA 2LQNA 2EO3A 4F5BA 4M4ZA 1O45A 2H8HA 3NHNA 3OP0A 1UUSA 1HCTB 1K9AA 2DCRA 4DGXA 1G83A 1O4DA 3IMDA 1AYDA 2Y3AB 4LUEA 1IJRA 1O4OA 1QADA 2Y1MA 2K79B 3VS4A 4OHHA 5EEQA 3QWXX 1M61A 1O4GA 3VRZA 2DM0A 2CR4A 1JWOA 4F59A 1KA6A 3BUMB 2GSBA 1UURA 2AUGA 1IS0A 2ECDA 1D4TA 1KC2A 1BLKA 1O4FA 2L4KA 3CXLA 3BUOB 1BKLA 4P9ZA 3S8OA 4JE4A 1CJ1A 1CWDL 5HKWA 1BFIA 4H1OA 3GXXA 1A1BA
chains in the Genus database with same CATH superfamily
2JYQA 1LCKA 3VRRA 1SPRA 2IUGA 4X6SA 5J3XA 2IZVA 2PNBA 1O46A 1R1SA 3TKZA 2EKXA 2LRAA 3HIZB 3GXWA 1A1AA 1A08A 2DLYA 2EYYA 5GJIA 2EOBA 1HCSB 2HDXA 1LKLA 3LYVA 1A1EA 5EG3B 2C0OA 2YU7A 1O4LA 3BUNB 3BUXB 2EYZA 2IUHA 2CS0A 1O42A 1LUIA 1O4KA 1BG1A 1O4QA 1X6CA 3VS6A 1BHFA 1LCJA 4WWQA 4H34A 3OV1A 4P9VA 3PS5A 1AYBA 1BKMA 1O41A 2EL8A 5D0JA 1O4NA 3M7FA 1FHSA 2KGYA 2SHPA 3PSJA 1AOTF 4E93A 2EU0A 1O4MA 1P13A 1O47A 1O4IA 2CI9A 1XA6A 5IBMA 1CWEA 4OHEA 2CRHA 3VS0A 2K7AB 4F5AA 3UYOA 2XP1A 4L1BB 1FU5A 1FU6A 5DC0B 4NWFA 1WQUA 1LUMA 1SHBA 2RMXA 1X27A 1JYQA 1NZVA 1SHDA 3OB1B 2QMSA 1AYCA 2PNAA 2C0TA 1NRVA 1O4PA 3IN7A 1B47A 1BFJA 2RORA 3VRYA 3VGOA 2PLDA 2ETZA 5AXIA 3OB2B 2B3OA 1AB2A 2DLZA 5HKZA 2OZOA 2Y1NA 4LUDA 4OHIA 1MW4A 4GWFA 1OPKA 1O43A 3N7YA 5HKYA 2OQ1A 1O4CA 2EYVA 3C7IA 2CIAA 3VS1A 1GRIA 4K11A 4U1PA 3WA4A 2FCIA 1CSYA 1SKJA 1O4BA 1O48A 5CDWA 3US4A 4EIHA 3OVEA 1BF5A 1OPLA 2LNXA 4OHDA 5EHPA 1LKKA 3PFVA 3VS7A 3T04A 5EELA 3CBLA 2AOAA 1AYAA 1FBZA 2CBLA 4NWGA 1YVHA 2HCKA 3BUWB 1MILA 1D1ZA 1R1QA 1AOUF 4FL2A 3CD3A 5DC4A 1F1WA 3VRQA 2L3TA 3UF4A 2LCTA 1GHUA 4U17A 1H9OA 4JGHA 1Y1UA 2DX0A 1O4RA 4A4CA 1LUNA 2KK6A 3IN8A 2YSXA 2CI8A 5EHRA 1BMBA 1O49A 4K44A 1BHHB 2VIFA 3ZNIA 1R1PA 1O4JA 1YVLA 1JYUA 1KA7A 3KFJA 4OHLA 4GPLB 2C0IA 4TZIA 3PSKA 1RJAA 2RSYA 4XZ1A 3MXCA 2GE9A 3VROA 5IBSA 3N84A 3N8MA 3K2TA 3VRNA 3PJPA 4GL9E 4EY0A 1ZFPE 3EACA 3K2MA 2BBUA 2H5KA 5AULA 1FMKA 1PICA 4QSYA 3VS3A 1CSZA 2MK2A 3VS2A 1I3ZA 4A4BA 5BO4A 4JEGA 1O4HA 1FYRA 3MAZA 1LUKA 2MRKA 1O44A 2LNWA 3VS5A 2HMHA 1O4AA 1F2FA 3S9KA 1SHAA 2DVJA 3TL0A 1M27A 2SRCA 1A09A 1RPYA 4XZ0A 1TZEE 1JU5A 2KNOA 2LQWA 4ROJA 1AD5A 4E68A 1A81A 2PLEA 3HHMB 2RVFA 3QWYA 2ABLA 3BKBA 1BHHA 2MRJA 3MXYA 1BLJA 5I6VA 1NZLA 2HUWA 2L6KA 3EAZA 3HCKA 3IMJA 1O4EA 2H46E 3S8NA 2HDVA 2PTKA 1QCFA 1A07A 2FO0A 2MQIA 3PLFB 4K2RA 1KSWA 2EO6A 1JYRA 5GJHA 3PQZA 3VRPA 1RQQC 1QG1E 2MC1A 1Y57A 4FL3A 3S8LA 4K45A 3GQIB 1BM2A 1OO4A 4D8KA 1A1CA 5DC9A 1Z3KA 5DF6A 1SPSA 1X0NA 1OO3A 4DGPA 4FBNA 2IUIA 2C9WA 1TCEA 1FBVA 2AOBA 1D4WA 5KAZA 3CWGA 2LQNA 2EO3A 4F5BA 4M4ZA 1O45A 2H8HA 3NHNA 3OP0A 1UUSA 1HCTB 1K9AA 2DCRA 4DGXA 1G83A 1O4DA 3IMDA 1AYDA 2Y3AB 4LUEA 1IJRA 1O4OA 1QADA 2Y1MA 2K79B 3VS4A 4OHHA 5EEQA 3QWXX 1M61A 1O4GA 3VRZA 2DM0A 2CR4A 1JWOA 4F59A 1KA6A 3BUMB 2GSBA 1UURA 2AUGA 1IS0A 2ECDA 1D4TA 1KC2A 1BLKA 1O4FA 2L4KA 3CXLA 3BUOB 1BKLA 4P9ZA 3S8OA 4JE4A 1CJ1A 1CWDL 5HKWA 1BFIA 4H1OA 3GXXA 1A1BA
chains in the Genus database with same CATH topology
2JYQA 1LCKA 3VRRA 1SPRA 2IUGA 4X6SA 5J3XA 2IZVA 2PNBA 1O46A 1R1SA 3TKZA 2EKXA 3HIZB 3GXWA 1A1AA 1A08A 2DLYA 2EYYA 5GJIA 2EOBA 1HCSB 2HDXA 1LKLA 1A1EA 5EG3B 2C0OA 2YU7A 1O4LA 3BUNB 3BUXB 2EYZA 2IUHA 2CS0A 1O42A 1LUIA 1O4KA 1BG1A 1O4QA 1X6CA 3VS6A 1BHFA 1LCJA 4WWQA 4H34A 3OV1A 4P9VA 3PS5A 1AYBA 1BKMA 1O41A 2EL8A 5D0JA 1O4NA 3M7FA 1FHSA 2SHPA 3PSJA 1AOTF 4E93A 2EU0A 1O4MA 1P13A 1O47A 1O4IA 2CI9A 1XA6A 5IBMA 1CWEA 4OHEA 2CRHA 3VS0A 2K7AB 4F5AA 3UYOA 2XP1A 4L1BB 1FU5A 1FU6A 5DC0B 4NWFA 1WQUA 1LUMA 1SHBA 2RMXA 1X27A 1JYQA 1NZVA 1SHDA 3OB1B 2QMSA 1AYCA 2PNAA 2C0TA 1NRVA 1O4PA 3IN7A 1B47A 1BFJA 2RORA 3VRYA 3VGOA 2PLDA 2ETZA 5AXIA 3OB2B 2B3OA 1AB2A 2DLZA 5HKZA 2OZOA 2Y1NA 4LUDA 4OHIA 1MW4A 4GWFA 1OPKA 1O43A 3N7YA 5HKYA 2OQ1A 1O4CA 2EYVA 3C7IA 2CIAA 3VS1A 1GRIA 4K11A 4U1PA 3WA4A 2FCIA 1CSYA 1SKJA 1O4BA 1O48A 5CDWA 3US4A 4EIHA 3OVEA 1BF5A 1OPLA 2LNXA 4OHDA 5EHPA 1LKKA 3PFVA 3VS7A 3T04A 5EELA 3CBLA 2AOAA 1AYAA 1FBZA 2CBLA 4NWGA 1YVHA 2HCKA 3BUWB 1MILA 1D1ZA 1R1QA 1AOUF 4FL2A 3CD3A 5DC4A 1F1WA 3VRQA 2L3TA 3UF4A 2LCTA 1GHUA 4U17A 1H9OA 4JGHA 1Y1UA 2DX0A 1O4RA 4A4CA 1LUNA 2KK6A 3IN8A 2YSXA 2CI8A 5EHRA 1BMBA 1O49A 4K44A 1BHHB 2VIFA 3ZNIA 1R1PA 1O4JA 1YVLA 1JYUA 1KA7A 3KFJA 4OHLA 4GPLB 2C0IA 4TZIA 3PSKA 1RJAA 2RSYA 4XZ1A 3MXCA 2GE9A 3VROA 5IBSA 3N84A 3N8MA 3VRNA 3PJPA 4GL9E 4EY0A 1ZFPE 3EACA 3K2MA 2BBUA 2H5KA 5AULA 1FMKA 1PICA 4QSYA 3VS3A 1CSZA 2MK2A 3VS2A 1I3ZA 4A4BA 5BO4A 4JEGA 1O4HA 1FYRA 3MAZA 1LUKA 2MRKA 1O44A 2LNWA 3VS5A 2HMHA 1O4AA 1F2FA 3S9KA 1SHAA 2DVJA 3TL0A 1M27A 2SRCA 1A09A 1RPYA 4XZ0A 1TZEE 1JU5A 2KNOA 2LQWA 4ROJA 1AD5A 4E68A 1A81A 2PLEA 3HHMB 2RVFA 3QWYA 2ABLA 3BKBA 1BHHA 2MRJA 3MXYA 1BLJA 5I6VA 1NZLA 2HUWA 2L6KA 3EAZA 3HCKA 3IMJA 1O4EA 2H46E 3S8NA 2HDVA 2PTKA 1QCFA 1A07A 2FO0A 2MQIA 3PLFB 4K2RA 1KSWA 2EO6A 1JYRA 5GJHA 3PQZA 3VRPA 1RQQC 1QG1E 2MC1A 1Y57A 4FL3A 3S8LA 4K45A 3GQIB 1BM2A 1OO4A 4D8KA 1A1CA 5DC9A 1Z3KA 5DF6A 1SPSA 1X0NA 1OO3A 4DGPA 4FBNA 2IUIA 2C9WA 1TCEA 1FBVA 2AOBA 1D4WA 5KAZA 3CWGA 2LQNA 2EO3A 4F5BA 4M4ZA 1O45A 2H8HA 3NHNA 3OP0A 1UUSA 1HCTB 1K9AA 2DCRA 4DGXA 1G83A 1O4DA 3IMDA 1AYDA 2Y3AB 4LUEA 1IJRA 1O4OA 1QADA 2Y1MA 2K79B 3VS4A 4OHHA 5EEQA 3QWXX 1M61A 1O4GA 3VRZA 2DM0A 2CR4A 1JWOA 4F59A 1KA6A 3BUMB 2GSBA 1UURA 2AUGA 1IS0A 2ECDA 1D4TA 1KC2A 1BLKA 1O4FA 2L4KA 3CXLA 3BUOB 1BKLA 4P9ZA 3S8OA 4JE4A 1CJ1A 1CWDL 5HKWA 1BFIA 4H1OA 3GXXA 1A1BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JYQ A;  1LCK A;  3VRR A;  1SPR A;  2IUG A;  4X6S A;  5J3X A;  2IZV A;  2PNB A;  1O46 A;  1R1S A;  3TKZ A;  2EKX A;  3HIZ B;  3GXW A;  1A1A A;  1A08 A;  2DLY A;  2EYY A;  5GJI A;  2EOB A;  1HCS B;  2HDX A;  1LKL A;  1A1E A;  5EG3 B;  2C0O A;  2YU7 A;  1O4L A;  3BUN B;  3BUX B;  2EYZ A;  2IUH A;  2CS0 A;  1O42 A;  1LUI A;  1O4K A;  1BG1 A;  1O4Q A;  1X6C A;  3VS6 A;  1BHF A;  1LCJ A;  4WWQ A;  4H34 A;  3OV1 A;  4P9V A;  3PS5 A;  1AYB A;  1BKM A;  1O41 A;  2EL8 A;  5D0J A;  1O4N A;  3M7F A;  1FHS A;  2SHP A;  3PSJ A;  1AOT F;  4E93 A;  2EU0 A;  1O4M A;  1P13 A;  1O47 A;  1O4I A;  2CI9 A;  1XA6 A;  5IBM A;  1CWE A;  4OHE A;  2CRH A;  3VS0 A;  2K7A B;  4F5A A;  3UYO A;  2XP1 A;  4L1B B;  1FU5 A;  1FU6 A;  5DC0 B;  4NWF A;  1WQU A;  1LUM A;  1SHB A;  2RMX A;  1X27 A;  1JYQ A;  1NZV A;  1SHD A;  3OB1 B;  2QMS A;  1AYC A;  2PNA A;  2C0T A;  1NRV A;  1O4P A;  3IN7 A;  1B47 A;  1BFJ A;  2ROR A;  3VRY A;  3VGO A;  2PLD A;  2ETZ A;  5AXI A;  3OB2 B;  2B3O A;  1AB2 A;  2DLZ A;  5HKZ A;  2OZO A;  2Y1N A;  4LUD A;  4OHI A;  1MW4 A;  4GWF A;  1OPK A;  1O43 A;  3N7Y A;  5HKY A;  2OQ1 A;  1O4C A;  2EYV A;  3C7I A;  2CIA A;  3VS1 A;  1GRI A;  4K11 A;  4U1P A;  3WA4 A;  2FCI A;  1CSY A;  1SKJ A;  1O4B A;  1O48 A;  5CDW A;  3US4 A;  4EIH A;  3OVE A;  1BF5 A;  1OPL A;  2LNX A;  4OHD A;  5EHP A;  1LKK A;  3PFV A;  3VS7 A;  3T04 A;  5EEL A;  3CBL A;  2AOA A;  1AYA A;  1FBZ A;  2CBL A;  4NWG A;  1YVH A;  2HCK A;  3BUW B;  1MIL A;  1D1Z A;  1R1Q A;  1AOU F;  4FL2 A;  3CD3 A;  5DC4 A;  1F1W A;  3VRQ A;  2L3T A;  3UF4 A;  2LCT A;  1GHU A;  4U17 A;  1H9O A;  4JGH A;  1Y1U A;  2DX0 A;  1O4R A;  4A4C A;  1LUN A;  2KK6 A;  3IN8 A;  2YSX A;  2CI8 A;  5EHR A;  1BMB A;  1O49 A;  4K44 A;  1BHH B;  2VIF A;  3ZNI A;  1R1P A;  1O4J A;  1YVL A;  1JYU A;  1KA7 A;  3KFJ A;  4OHL A;  4GPL B;  2C0I A;  4TZI A;  3PSK A;  1RJA A;  2RSY A;  4XZ1 A;  3MXC A;  2GE9 A;  3VRO A;  5IBS A;  3N84 A;  3N8M A;  3VRN A;  3PJP A;  4GL9 E;  4EY0 A;  1ZFP E;  3EAC A;  3K2M A;  2BBU A;  2H5K A;  5AUL A;  1FMK A;  1PIC A;  4QSY A;  3VS3 A;  1CSZ A;  2MK2 A;  3VS2 A;  1I3Z A;  4A4B A;  5BO4 A;  4JEG A;  1O4H A;  1FYR A;  3MAZ A;  1LUK A;  2MRK A;  1O44 A;  2LNW A;  3VS5 A;  2HMH A;  1O4A A;  1F2F A;  3S9K A;  1SHA A;  2DVJ A;  3TL0 A;  1M27 A;  2SRC A;  1A09 A;  1RPY A;  4XZ0 A;  1TZE E;  1JU5 A;  2KNO A;  2LQW A;  4ROJ A;  1AD5 A;  4E68 A;  1A81 A;  2PLE A;  3HHM B;  2RVF A;  3QWY A;  2ABL A;  3BKB A;  1BHH A;  2MRJ A;  3MXY A;  1BLJ A;  5I6V A;  1NZL A;  2HUW A;  2L6K A;  3EAZ A;  3HCK A;  3IMJ A;  1O4E A;  2H46 E;  3S8N A;  2HDV A;  2PTK A;  1QCF A;  1A07 A;  2FO0 A;  2MQI A;  3PLF B;  4K2R A;  1KSW A;  2EO6 A;  1JYR A;  5GJH A;  3PQZ A;  3VRP A;  1RQQ C;  1QG1 E;  2MC1 A;  1Y57 A;  4FL3 A;  3S8L A;  4K45 A;  3GQI B;  1BM2 A;  1OO4 A;  4D8K A;  1A1C A;  5DC9 A;  1Z3K A;  5DF6 A;  1SPS A;  1X0N A;  1OO3 A;  4DGP A;  4FBN A;  2IUI A;  2C9W A;  1TCE A;  1FBV A;  2AOB A;  1D4W A;  5KAZ A;  3CWG A;  2LQN A;  2EO3 A;  4F5B A;  4M4Z A;  1O45 A;  2H8H A;  3NHN A;  3OP0 A;  1UUS A;  1HCT B;  1K9A A;  2DCR A;  4DGX A;  1G83 A;  1O4D A;  3IMD A;  1AYD A;  2Y3A B;  4LUE A;  1IJR A;  1O4O A;  1QAD A;  2Y1M A;  2K79 B;  3VS4 A;  4OHH A;  5EEQ A;  3QWX X;  1M61 A;  1O4G A;  3VRZ A;  2DM0 A;  2CR4 A;  1JWO A;  4F59 A;  1KA6 A;  3BUM B;  2GSB A;  1UUR A;  2AUG A;  1IS0 A;  2ECD A;  1D4T A;  1KC2 A;  1BLK A;  1O4F A;  2L4K A;  3CXL A;  3BUO B;  1BKL A;  4P9Z A;  3S8O A;  4JE4 A;  1CJ1 A;  1CWD L;  5HKW A;  1BFI A;  4H1O A;  3GXX A;  1A1B A; 
#chains in the Genus database with same CATH topology
 2JYQ A;  1LCK A;  3VRR A;  1SPR A;  2IUG A;  4X6S A;  5J3X A;  2IZV A;  2PNB A;  1O46 A;  1R1S A;  3TKZ A;  2EKX A;  2LRA A;  3HIZ B;  3GXW A;  1A1A A;  1A08 A;  2DLY A;  2EYY A;  5GJI A;  2EOB A;  1HCS B;  2HDX A;  1LKL A;  3LYV A;  1A1E A;  5EG3 B;  2C0O A;  2YU7 A;  1O4L A;  3BUN B;  3BUX B;  2EYZ A;  2IUH A;  2CS0 A;  1O42 A;  1LUI A;  1O4K A;  1BG1 A;  1O4Q A;  1X6C A;  3VS6 A;  1BHF A;  1LCJ A;  4WWQ A;  4H34 A;  3OV1 A;  4P9V A;  3PS5 A;  1AYB A;  1BKM A;  1O41 A;  2EL8 A;  5D0J A;  1O4N A;  3M7F A;  1FHS A;  2KGY A;  2SHP A;  3PSJ A;  1AOT F;  4E93 A;  2EU0 A;  1O4M A;  1P13 A;  1O47 A;  1O4I A;  2CI9 A;  1XA6 A;  5IBM A;  1CWE A;  4OHE A;  2CRH A;  3VS0 A;  2K7A B;  4F5A A;  3UYO A;  2XP1 A;  4L1B B;  1FU5 A;  1FU6 A;  5DC0 B;  4NWF A;  1WQU A;  1LUM A;  1SHB A;  2RMX A;  1X27 A;  1JYQ A;  1NZV A;  1SHD A;  3OB1 B;  2QMS A;  1AYC A;  2PNA A;  2C0T A;  1NRV A;  1O4P A;  3IN7 A;  1B47 A;  1BFJ A;  2ROR A;  3VRY A;  3VGO A;  2PLD A;  2ETZ A;  5AXI A;  3OB2 B;  2B3O A;  1AB2 A;  2DLZ A;  5HKZ A;  2OZO A;  2Y1N A;  4LUD A;  4OHI A;  1MW4 A;  4GWF A;  1OPK A;  1O43 A;  3N7Y A;  5HKY A;  2OQ1 A;  1O4C A;  2EYV A;  3C7I A;  2CIA A;  3VS1 A;  1GRI A;  4K11 A;  4U1P A;  3WA4 A;  2FCI A;  1CSY A;  1SKJ A;  1O4B A;  1O48 A;  5CDW A;  3US4 A;  4EIH A;  3OVE A;  1BF5 A;  1OPL A;  2LNX A;  4OHD A;  5EHP A;  1LKK A;  3PFV A;  3VS7 A;  3T04 A;  5EEL A;  3CBL A;  2AOA A;  1AYA A;  1FBZ A;  2CBL A;  4NWG A;  1YVH A;  2HCK A;  3BUW B;  1MIL A;  1D1Z A;  1R1Q A;  1AOU F;  4FL2 A;  3CD3 A;  5DC4 A;  1F1W A;  3VRQ A;  2L3T A;  3UF4 A;  2LCT A;  1GHU A;  4U17 A;  1H9O A;  4JGH A;  1Y1U A;  2DX0 A;  1O4R A;  4A4C A;  1LUN A;  2KK6 A;  3IN8 A;  2YSX A;  2CI8 A;  5EHR A;  1BMB A;  1O49 A;  4K44 A;  1BHH B;  2VIF A;  3ZNI A;  1R1P A;  1O4J A;  1YVL A;  1JYU A;  1KA7 A;  3KFJ A;  4OHL A;  4GPL B;  2C0I A;  4TZI A;  3PSK A;  1RJA A;  2RSY A;  4XZ1 A;  3MXC A;  2GE9 A;  3VRO A;  5IBS A;  3N84 A;  3N8M A;  3K2T A;  3VRN A;  3PJP A;  4GL9 E;  4EY0 A;  1ZFP E;  3EAC A;  3K2M A;  2BBU A;  2H5K A;  5AUL A;  1FMK A;  1PIC A;  4QSY A;  3VS3 A;  1CSZ A;  2MK2 A;  3VS2 A;  1I3Z A;  4A4B A;  5BO4 A;  4JEG A;  1O4H A;  1FYR A;  3MAZ A;  1LUK A;  2MRK A;  1O44 A;  2LNW A;  3VS5 A;  2HMH A;  1O4A A;  1F2F A;  3S9K A;  1SHA A;  2DVJ A;  3TL0 A;  1M27 A;  2SRC A;  1A09 A;  1RPY A;  4XZ0 A;  1TZE E;  1JU5 A;  2KNO A;  2LQW A;  4ROJ A;  1AD5 A;  4E68 A;  1A81 A;  2PLE A;  3HHM B;  2RVF A;  3QWY A;  2ABL A;  3BKB A;  1BHH A;  2MRJ A;  3MXY A;  1BLJ A;  5I6V A;  1NZL A;  2HUW A;  2L6K A;  3EAZ A;  3HCK A;  3IMJ A;  1O4E A;  2H46 E;  3S8N A;  2HDV A;  2PTK A;  1QCF A;  1A07 A;  2FO0 A;  2MQI A;  3PLF B;  4K2R A;  1KSW A;  2EO6 A;  1JYR A;  5GJH A;  3PQZ A;  3VRP A;  1RQQ C;  1QG1 E;  2MC1 A;  1Y57 A;  4FL3 A;  3S8L A;  4K45 A;  3GQI B;  1BM2 A;  1OO4 A;  4D8K A;  1A1C A;  5DC9 A;  1Z3K A;  5DF6 A;  1SPS A;  1X0N A;  1OO3 A;  4DGP A;  4FBN A;  2IUI A;  2C9W A;  1TCE A;  1FBV A;  2AOB A;  1D4W A;  5KAZ A;  3CWG A;  2LQN A;  2EO3 A;  4F5B A;  4M4Z A;  1O45 A;  2H8H A;  3NHN A;  3OP0 A;  1UUS A;  1HCT B;  1K9A A;  2DCR A;  4DGX A;  1G83 A;  1O4D A;  3IMD A;  1AYD A;  2Y3A B;  4LUE A;  1IJR A;  1O4O A;  1QAD A;  2Y1M A;  2K79 B;  3VS4 A;  4OHH A;  5EEQ A;  3QWX X;  1M61 A;  1O4G A;  3VRZ A;  2DM0 A;  2CR4 A;  1JWO A;  4F59 A;  1KA6 A;  3BUM B;  2GSB A;  1UUR A;  2AUG A;  1IS0 A;  2ECD A;  1D4T A;  1KC2 A;  1BLK A;  1O4F A;  2L4K A;  3CXL A;  3BUO B;  1BKL A;  4P9Z A;  3S8O A;  4JE4 A;  1CJ1 A;  1CWD L;  5HKW A;  1BFI A;  4H1O A;  3GXX A;  1A1B A; 
#chains in the Genus database with same CATH homology
 2JYQ A;  1LCK A;  3VRR A;  1SPR A;  2IUG A;  4X6S A;  5J3X A;  2IZV A;  2PNB A;  1O46 A;  1R1S A;  3TKZ A;  2EKX A;  3HIZ B;  3GXW A;  1A1A A;  1A08 A;  2DLY A;  2EYY A;  5GJI A;  2EOB A;  1HCS B;  2HDX A;  1LKL A;  1A1E A;  5EG3 B;  2C0O A;  2YU7 A;  1O4L A;  3BUN B;  3BUX B;  2EYZ A;  2IUH A;  2CS0 A;  1O42 A;  1LUI A;  1O4K A;  1BG1 A;  1O4Q A;  1X6C A;  3VS6 A;  1BHF A;  1LCJ A;  4WWQ A;  4H34 A;  3OV1 A;  4P9V A;  3PS5 A;  1AYB A;  1BKM A;  1O41 A;  2EL8 A;  5D0J A;  1O4N A;  3M7F A;  1FHS A;  2SHP A;  3PSJ A;  1AOT F;  4E93 A;  2EU0 A;  1O4M A;  1P13 A;  1O47 A;  1O4I A;  2CI9 A;  1XA6 A;  5IBM A;  1CWE A;  4OHE A;  2CRH A;  3VS0 A;  2K7A B;  4F5A A;  3UYO A;  2XP1 A;  4L1B B;  1FU5 A;  1FU6 A;  5DC0 B;  4NWF A;  1WQU A;  1LUM A;  1SHB A;  2RMX A;  1X27 A;  1JYQ A;  1NZV A;  1SHD A;  3OB1 B;  2QMS A;  1AYC A;  2PNA A;  2C0T A;  1NRV A;  1O4P A;  3IN7 A;  1B47 A;  1BFJ A;  2ROR A;  3VRY A;  3VGO A;  2PLD A;  2ETZ A;  5AXI A;  3OB2 B;  2B3O A;  1AB2 A;  2DLZ A;  5HKZ A;  2OZO A;  2Y1N A;  4LUD A;  4OHI A;  1MW4 A;  4GWF A;  1OPK A;  1O43 A;  3N7Y A;  5HKY A;  2OQ1 A;  1O4C A;  2EYV A;  3C7I A;  2CIA A;  3VS1 A;  1GRI A;  4K11 A;  4U1P A;  3WA4 A;  2FCI A;  1CSY A;  1SKJ A;  1O4B A;  1O48 A;  5CDW A;  3US4 A;  4EIH A;  3OVE A;  1BF5 A;  1OPL A;  2LNX A;  4OHD A;  5EHP A;  1LKK A;  3PFV A;  3VS7 A;  3T04 A;  5EEL A;  3CBL A;  2AOA A;  1AYA A;  1FBZ A;  2CBL A;  4NWG A;  1YVH A;  2HCK A;  3BUW B;  1MIL A;  1D1Z A;  1R1Q A;  1AOU F;  4FL2 A;  3CD3 A;  5DC4 A;  1F1W A;  3VRQ A;  2L3T A;  3UF4 A;  2LCT A;  1GHU A;  4U17 A;  1H9O A;  4JGH A;  1Y1U A;  2DX0 A;  1O4R A;  4A4C A;  1LUN A;  2KK6 A;  3IN8 A;  2YSX A;  2CI8 A;  5EHR A;  1BMB A;  1O49 A;  4K44 A;  1BHH B;  2VIF A;  3ZNI A;  1R1P A;  1O4J A;  1YVL A;  1JYU A;  1KA7 A;  3KFJ A;  4OHL A;  4GPL B;  2C0I A;  4TZI A;  3PSK A;  1RJA A;  2RSY A;  4XZ1 A;  3MXC A;  2GE9 A;  3VRO A;  5IBS A;  3N84 A;  3N8M A;  3VRN A;  3PJP A;  4GL9 E;  4EY0 A;  1ZFP E;  3EAC A;  3K2M A;  2BBU A;  2H5K A;  5AUL A;  1FMK A;  1PIC A;  4QSY A;  3VS3 A;  1CSZ A;  2MK2 A;  3VS2 A;  1I3Z A;  4A4B A;  5BO4 A;  4JEG A;  1O4H A;  1FYR A;  3MAZ A;  1LUK A;  2MRK A;  1O44 A;  2LNW A;  3VS5 A;  2HMH A;  1O4A A;  1F2F A;  3S9K A;  1SHA A;  2DVJ A;  3TL0 A;  1M27 A;  2SRC A;  1A09 A;  1RPY A;  4XZ0 A;  1TZE E;  1JU5 A;  2KNO A;  2LQW A;  4ROJ A;  1AD5 A;  4E68 A;  1A81 A;  2PLE A;  3HHM B;  2RVF A;  3QWY A;  2ABL A;  3BKB A;  1BHH A;  2MRJ A;  3MXY A;  1BLJ A;  5I6V A;  1NZL A;  2HUW A;  2L6K A;  3EAZ A;  3HCK A;  3IMJ A;  1O4E A;  2H46 E;  3S8N A;  2HDV A;  2PTK A;  1QCF A;  1A07 A;  2FO0 A;  2MQI A;  3PLF B;  4K2R A;  1KSW A;  2EO6 A;  1JYR A;  5GJH A;  3PQZ A;  3VRP A;  1RQQ C;  1QG1 E;  2MC1 A;  1Y57 A;  4FL3 A;  3S8L A;  4K45 A;  3GQI B;  1BM2 A;  1OO4 A;  4D8K A;  1A1C A;  5DC9 A;  1Z3K A;  5DF6 A;  1SPS A;  1X0N A;  1OO3 A;  4DGP A;  4FBN A;  2IUI A;  2C9W A;  1TCE A;  1FBV A;  2AOB A;  1D4W A;  5KAZ A;  3CWG A;  2LQN A;  2EO3 A;  4F5B A;  4M4Z A;  1O45 A;  2H8H A;  3NHN A;  3OP0 A;  1UUS A;  1HCT B;  1K9A A;  2DCR A;  4DGX A;  1G83 A;  1O4D A;  3IMD A;  1AYD A;  2Y3A B;  4LUE A;  1IJR A;  1O4O A;  1QAD A;  2Y1M A;  2K79 B;  3VS4 A;  4OHH A;  5EEQ A;  3QWX X;  1M61 A;  1O4G A;  3VRZ A;  2DM0 A;  2CR4 A;  1JWO A;  4F59 A;  1KA6 A;  3BUM B;  2GSB A;  1UUR A;  2AUG A;  1IS0 A;  2ECD A;  1D4T A;  1KC2 A;  1BLK A;  1O4F A;  2L4K A;  3CXL A;  3BUO B;  1BKL A;  4P9Z A;  3S8O A;  4JE4 A;  1CJ1 A;  1CWD L;  5HKW A;  1BFI A;  4H1O A;  3GXX A;  1A1B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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