4FBNA

Insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
243
structure length
232
Chain Sequence
NEKWFHGKLGAGDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGYVEANPM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga
total genus 58
structure length 232
sequence length 243
ec nomenclature ec 3.1.4.11: Phosphoinositide phospholipase C.
pdb deposition date 2012-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4fbnA02
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4fbnA01
1CWDL 2EL8A 4TZIA 2LQNA 3BUXB 1O4NA 3K2MA 1BHHB 5AULA 3HIZB 1O4BA 1FYRA 4OHEA 4OHLA 2IZVA 4LUDA 2CBLA 1O4OA 2SRCA 4H1OA 1I3ZA 4U17A 1A1AA 3OB2B 2LNXA 4K44A 3OB1B 1A1CA 2Y3AB 1UUSA 1SHBA 1KSWA 2YU7A 4K45A 3S8OA 1D4WA 2GE9A 1X0NA 1MW4A 5EHRA 4F5AA 1BHFA 1AOUF 1CSZA 2GSBA 5HKWA 2EO6A 2EO3A 3VS6A 3QWYA 3OVEA 1RQQC 4WWQA 1A81A 4FL3A 3BUOB 1M61A 1O4LA 2CRHA 2HDXA 3IMDA 3HCKA 3M7FA 1O48A 4FBNA 5CDWA 2K7AB 3GQIB 2K79B 5EG3B 1O4PA 4D8KA 5KAZA 1BMBA 1R1PA 1HCTB 2JYQA 1O4GA 2SHPA 3VS2A 3IN8A 2PTKA 5DC9A 2ECDA 1NRVA 1WQUA 1GHUA 2B3OA 1AYAA 2HUWA 1O45A 2EYVA 3N8MA 1AYDA 1O4IA 1OO3A 4H34A 3MAZA 4U1PA 5EELA 4P9ZA 2AUGA 1Y1UA 1A07A 5D0JA 2IUIA 1RPYA 4JEGA 2CS0A 2HCKA 1BLKA 2OQ1A 3HHMB 3TKZA 2KNOA 4F59A 1KC2A 3IMJA 1XA6A 2VIFA 2MK2A 1KA6A 1O4HA 2LQWA 2FO0A 3CXLA 2PLEA 3WA4A 2CR4A 3N7YA 1Z3KA 1R1QA 1SHDA 1O49A 1X6CA 3VS0A 3VGOA 1OO4A 1K9AA 2C0IA 1SKJA 1O4AA 1YVLA 1GRIA 1O42A 4X6SA 3PSKA 2MC1A 2EU0A 2EYYA 2RMXA 1SPRA 1LCJA 1LUNA 4K2RA 4DGPA 1A09A 1QCFA 2CI8A 4P9VA 2PLDA 1BF5A 1AYBA 1O4FA 1JU5A 5AXIA 1AYCA 2AOAA 4A4BA 2Y1MA 1X27A 1AD5A 3EAZA 4A4CA 3ZNIA 4QSYA 1D1ZA 1OPKA 1BHHA 1LKKA 1CWEA 3VS4A 1BKMA 3UYOA 2EOBA 4LUEA 3VRRA 2ETZA 3PJPA 4OHDA 4NWGA 1NZVA 2IUHA 1O46A 4EY0A 2CI9A 2L6KA 3BUMB 1O43A 2EYZA 1O47A 4XZ0A 5GJIA 5EHPA 4OHIA 1FBVA 5DC0B 5DF6A 3VS3A 1O4EA 1R1SA 1M27A 5IBSA 3VRPA 1O4DA 2XP1A 2QMSA 3N84A 2L3TA 1JYRA 1CSYA 1BKLA 1G83A 1HCSB 3S8NA 2C0TA 3NHNA 1IJRA 1BFJA 3CD3A 4EIHA 3VS7A 3CBLA 3EACA 1B47A 2H5KA 2DLZA 1O4QA 3OP0A 3VRQA 2AOBA 4NWFA 1H9OA 5I6VA 3CWGA 4F5BA 4DGXA 3MXYA 4JE4A 2DVJA 2MQIA 1BM2A 2Y1NA 1TZEE 3MXCA 1YVHA 1LKLA 3VRZA 1F2FA 1A1EA 3BUWB 3PSJA 2EKXA 1JYQA 5GJHA 5EEQA 2IUGA 1MILA 2LNWA 3T04A 3PS5A 1CJ1A 1FU5A 3S9KA 4E93A 4GPLB 2DCRA 3UF4A 4L1BB 2PNBA 1O4RA 2BBUA 1AB2A 3VS5A 1NZLA 2C9WA 1LUKA 4GWFA 2C0OA 1O4KA 1SPSA 1FBZA 1RJAA 2HDVA 1ZFPE 5J3XA 2FCIA 5HKZA 1BLJA 3PFVA 1QG1E 1F1WA 4JGHA 2RORA 1UURA 2LCTA 1AOTF 2L4KA 4M4ZA 4E68A 1OPLA 1SHAA 3GXXA 3PQZA 1LUIA 2H8HA 1O4CA 3VS1A 5BO4A 5HKYA 3VRYA 1BG1A 5IBMA 4K11A 1QADA 3S8LA 3BKBA 2H46E 2KK6A 1D4TA 1TCEA 2DM0A 1P13A 2DX0A 2ABLA 3US4A 1LUMA 3VROA 2RVFA 1PICA 1O4JA 4ROJA 2YSXA 1FHSA 3TL0A 2PNAA 1A1BA 4XZ1A 3BUNB 1KA7A 1JWOA 3KFJA 3PLFB 3IN7A 1JYUA 2MRKA 1IS0A 1FMKA 4FL2A 2RSYA 2MRJA 1BFIA 2OZOA 2CIAA 3C7IA 3OV1A 3GXWA 1A08A 3QWXX 1FU6A 1O41A 2DLYA 4OHHA 1LCKA 3VRNA 5DC4A 4GL9E 1O44A 1Y57A 2HMHA 1O4MA
chains in the Genus database with same CATH superfamily
1CWDL 2EL8A 4TZIA 2LQNA 3BUXB 1O4NA 3K2MA 1BHHB 5AULA 3HIZB 1O4BA 1FYRA 4OHEA 4OHLA 2IZVA 4LUDA 2CBLA 1O4OA 2SRCA 4H1OA 1I3ZA 4U17A 1A1AA 3OB2B 2LNXA 4K44A 3OB1B 1A1CA 2Y3AB 1UUSA 1SHBA 1KSWA 2YU7A 4K45A 3S8OA 1D4WA 2GE9A 1X0NA 1MW4A 5EHRA 4F5AA 1BHFA 1AOUF 1CSZA 2GSBA 5HKWA 2EO6A 2EO3A 3VS6A 3QWYA 3OVEA 1RQQC 4WWQA 1A81A 4FL3A 3BUOB 1M61A 1O4LA 2CRHA 2HDXA 3IMDA 3HCKA 3M7FA 1O48A 4FBNA 5CDWA 2K7AB 3GQIB 2K79B 5EG3B 1O4PA 4D8KA 5KAZA 1BMBA 1R1PA 1HCTB 2JYQA 1O4GA 2SHPA 3VS2A 3IN8A 2PTKA 5DC9A 2ECDA 1NRVA 1WQUA 1GHUA 2B3OA 1AYAA 2HUWA 1O45A 2EYVA 3N8MA 1AYDA 1O4IA 1OO3A 4H34A 3MAZA 4U1PA 5EELA 3K2TA 4P9ZA 2AUGA 1Y1UA 1A07A 5D0JA 2IUIA 1RPYA 4JEGA 2LRAA 2CS0A 2HCKA 1BLKA 2OQ1A 3HHMB 3TKZA 2KNOA 4F59A 1KC2A 3IMJA 3LYVA 1XA6A 2VIFA 2MK2A 1KA6A 1O4HA 2LQWA 2FO0A 3CXLA 2PLEA 3WA4A 2CR4A 3N7YA 1Z3KA 1R1QA 1SHDA 1O49A 1X6CA 3VS0A 3VGOA 1OO4A 1K9AA 2C0IA 1SKJA 1O4AA 1YVLA 1GRIA 1O42A 4X6SA 3PSKA 2MC1A 2EU0A 2EYYA 2RMXA 1SPRA 1LCJA 1LUNA 4K2RA 4DGPA 1A09A 1QCFA 2CI8A 4P9VA 2PLDA 1BF5A 1AYBA 1O4FA 1JU5A 5AXIA 1AYCA 2AOAA 4A4BA 2Y1MA 1X27A 1AD5A 3EAZA 4A4CA 3ZNIA 4QSYA 1D1ZA 1OPKA 1BHHA 1LKKA 1CWEA 3VS4A 1BKMA 3UYOA 2EOBA 4LUEA 3VRRA 2ETZA 3PJPA 4OHDA 4NWGA 1NZVA 2IUHA 1O46A 4EY0A 2CI9A 2L6KA 3BUMB 1O43A 2EYZA 1O47A 4XZ0A 5GJIA 5EHPA 4OHIA 1FBVA 5DC0B 5DF6A 3VS3A 1O4EA 1R1SA 1M27A 5IBSA 3VRPA 1O4DA 2XP1A 2QMSA 3N84A 2L3TA 1JYRA 1CSYA 1BKLA 1G83A 1HCSB 3S8NA 2C0TA 3NHNA 1IJRA 1BFJA 3CD3A 4EIHA 3VS7A 3CBLA 3EACA 1B47A 2H5KA 2DLZA 1O4QA 3OP0A 3VRQA 2AOBA 4NWFA 1H9OA 5I6VA 3CWGA 4F5BA 4DGXA 3MXYA 4JE4A 2DVJA 2MQIA 1BM2A 2Y1NA 1TZEE 3MXCA 1YVHA 1LKLA 3VRZA 1F2FA 1A1EA 3BUWB 3PSJA 2EKXA 1JYQA 5GJHA 5EEQA 2IUGA 1MILA 2LNWA 3T04A 3PS5A 1CJ1A 1FU5A 3S9KA 4E93A 4GPLB 2DCRA 3UF4A 4L1BB 2PNBA 1O4RA 2BBUA 1AB2A 3VS5A 1NZLA 2C9WA 1LUKA 4GWFA 2C0OA 2KGYA 1O4KA 1SPSA 1FBZA 1RJAA 2HDVA 1ZFPE 5J3XA 2FCIA 5HKZA 1BLJA 3PFVA 1QG1E 1F1WA 4JGHA 2RORA 1UURA 2LCTA 1AOTF 2L4KA 4M4ZA 4E68A 1OPLA 1SHAA 3GXXA 3PQZA 1LUIA 2H8HA 1O4CA 3VS1A 5BO4A 5HKYA 3VRYA 1BG1A 5IBMA 4K11A 1QADA 3S8LA 3BKBA 2H46E 2KK6A 1D4TA 1TCEA 2DM0A 1P13A 2DX0A 2ABLA 3US4A 1LUMA 3VROA 2RVFA 1PICA 1O4JA 4ROJA 2YSXA 1FHSA 3TL0A 2PNAA 1A1BA 4XZ1A 3BUNB 1KA7A 1JWOA 3KFJA 3PLFB 3IN7A 1JYUA 2MRKA 1IS0A 1FMKA 4FL2A 2RSYA 2MRJA 1BFIA 2OZOA 2CIAA 3C7IA 3OV1A 3GXWA 1A08A 3QWXX 1FU6A 1O41A 2DLYA 4OHHA 1LCKA 3VRNA 5DC4A 4GL9E 1O44A 1Y57A 2HMHA 1O4MA
chains in the Genus database with same CATH topology
1CWDL 2EL8A 4TZIA 2LQNA 3BUXB 1O4NA 3K2MA 1BHHB 5AULA 3HIZB 1O4BA 1FYRA 4OHEA 4OHLA 2IZVA 4LUDA 2CBLA 1O4OA 2SRCA 4H1OA 1I3ZA 4U17A 1A1AA 3OB2B 2LNXA 4K44A 3OB1B 1A1CA 2Y3AB 1UUSA 1SHBA 1KSWA 2YU7A 4K45A 3S8OA 1D4WA 2GE9A 1X0NA 1MW4A 5EHRA 4F5AA 1BHFA 1AOUF 1CSZA 2GSBA 5HKWA 2EO6A 2EO3A 3VS6A 3QWYA 3OVEA 1RQQC 4WWQA 1A81A 4FL3A 3BUOB 1M61A 1O4LA 2CRHA 2HDXA 3IMDA 3HCKA 3M7FA 1O48A 4FBNA 5CDWA 2K7AB 3GQIB 2K79B 5EG3B 1O4PA 4D8KA 5KAZA 1BMBA 1R1PA 1HCTB 2JYQA 1O4GA 2SHPA 3VS2A 3IN8A 2PTKA 5DC9A 2ECDA 1NRVA 1WQUA 1GHUA 2B3OA 1AYAA 2HUWA 1O45A 2EYVA 3N8MA 1AYDA 1O4IA 1OO3A 4H34A 3MAZA 4U1PA 5EELA 4P9ZA 2AUGA 1Y1UA 1A07A 5D0JA 2IUIA 1RPYA 4JEGA 2CS0A 2HCKA 1BLKA 2OQ1A 3HHMB 3TKZA 2KNOA 4F59A 1KC2A 3IMJA 1XA6A 2VIFA 2MK2A 1KA6A 1O4HA 2LQWA 2FO0A 3CXLA 2PLEA 3WA4A 2CR4A 3N7YA 1Z3KA 1R1QA 1SHDA 1O49A 1X6CA 3VS0A 3VGOA 1OO4A 1K9AA 2C0IA 1SKJA 1O4AA 1YVLA 1GRIA 1O42A 4X6SA 3PSKA 2MC1A 2EU0A 2EYYA 2RMXA 1SPRA 1LCJA 1LUNA 4K2RA 4DGPA 1A09A 1QCFA 2CI8A 4P9VA 2PLDA 1BF5A 1AYBA 1O4FA 1JU5A 5AXIA 1AYCA 2AOAA 4A4BA 2Y1MA 1X27A 1AD5A 3EAZA 4A4CA 3ZNIA 4QSYA 1D1ZA 1OPKA 1BHHA 1LKKA 1CWEA 3VS4A 1BKMA 3UYOA 2EOBA 4LUEA 3VRRA 2ETZA 3PJPA 4OHDA 4NWGA 1NZVA 2IUHA 1O46A 4EY0A 2CI9A 2L6KA 3BUMB 1O43A 2EYZA 1O47A 4XZ0A 5GJIA 5EHPA 4OHIA 1FBVA 5DC0B 5DF6A 3VS3A 1O4EA 1R1SA 1M27A 5IBSA 3VRPA 1O4DA 2XP1A 2QMSA 3N84A 2L3TA 1JYRA 1CSYA 1BKLA 1G83A 1HCSB 3S8NA 2C0TA 3NHNA 1IJRA 1BFJA 3CD3A 4EIHA 3VS7A 3CBLA 3EACA 1B47A 2H5KA 2DLZA 1O4QA 3OP0A 3VRQA 2AOBA 4NWFA 1H9OA 5I6VA 3CWGA 4F5BA 4DGXA 3MXYA 4JE4A 2DVJA 2MQIA 1BM2A 2Y1NA 1TZEE 3MXCA 1YVHA 1LKLA 3VRZA 1F2FA 1A1EA 3BUWB 3PSJA 2EKXA 1JYQA 5GJHA 5EEQA 2IUGA 1MILA 2LNWA 3T04A 3PS5A 1CJ1A 1FU5A 3S9KA 4E93A 4GPLB 2DCRA 3UF4A 4L1BB 2PNBA 1O4RA 2BBUA 1AB2A 3VS5A 1NZLA 2C9WA 1LUKA 4GWFA 2C0OA 1O4KA 1SPSA 1FBZA 1RJAA 2HDVA 1ZFPE 5J3XA 2FCIA 5HKZA 1BLJA 3PFVA 1QG1E 1F1WA 4JGHA 2RORA 1UURA 2LCTA 1AOTF 2L4KA 4M4ZA 4E68A 1OPLA 1SHAA 3GXXA 3PQZA 1LUIA 2H8HA 1O4CA 3VS1A 5BO4A 5HKYA 3VRYA 1BG1A 5IBMA 4K11A 1QADA 3S8LA 3BKBA 2H46E 2KK6A 1D4TA 1TCEA 2DM0A 1P13A 2DX0A 2ABLA 3US4A 1LUMA 3VROA 2RVFA 1PICA 1O4JA 4ROJA 2YSXA 1FHSA 3TL0A 2PNAA 1A1BA 4XZ1A 3BUNB 1KA7A 1JWOA 3KFJA 3PLFB 3IN7A 1JYUA 2MRKA 1IS0A 1FMKA 4FL2A 2RSYA 2MRJA 1BFIA 2OZOA 2CIAA 3C7IA 3OV1A 3GXWA 1A08A 3QWXX 1FU6A 1O41A 2DLYA 4OHHA 1LCKA 3VRNA 5DC4A 4GL9E 1O44A 1Y57A 2HMHA 1O4MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CWD L;  2EL8 A;  4TZI A;  2LQN A;  3BUX B;  1O4N A;  3K2M A;  1BHH B;  5AUL A;  3HIZ B;  1O4B A;  1FYR A;  4OHE A;  4OHL A;  2IZV A;  4LUD A;  2CBL A;  1O4O A;  2SRC A;  4H1O A;  1I3Z A;  4U17 A;  1A1A A;  3OB2 B;  2LNX A;  4K44 A;  3OB1 B;  1A1C A;  2Y3A B;  1UUS A;  1SHB A;  1KSW A;  2YU7 A;  4K45 A;  3S8O A;  1D4W A;  2GE9 A;  1X0N A;  1MW4 A;  5EHR A;  4F5A A;  1BHF A;  1AOU F;  1CSZ A;  2GSB A;  5HKW A;  2EO6 A;  2EO3 A;  3VS6 A;  3QWY A;  3OVE A;  1RQQ C;  4WWQ A;  1A81 A;  4FL3 A;  3BUO B;  1M61 A;  1O4L A;  2CRH A;  2HDX A;  3IMD A;  3HCK A;  3M7F A;  1O48 A;  4FBN A;  5CDW A;  2K7A B;  3GQI B;  2K79 B;  5EG3 B;  1O4P A;  4D8K A;  5KAZ A;  1BMB A;  1R1P A;  1HCT B;  2JYQ A;  1O4G A;  2SHP A;  3VS2 A;  3IN8 A;  2PTK A;  5DC9 A;  2ECD A;  1NRV A;  1WQU A;  1GHU A;  2B3O A;  1AYA A;  2HUW A;  1O45 A;  2EYV A;  3N8M A;  1AYD A;  1O4I A;  1OO3 A;  4H34 A;  3MAZ A;  4U1P A;  5EEL A;  4P9Z A;  2AUG A;  1Y1U A;  1A07 A;  5D0J A;  2IUI A;  1RPY A;  4JEG A;  2CS0 A;  2HCK A;  1BLK A;  2OQ1 A;  3HHM B;  3TKZ A;  2KNO A;  4F59 A;  1KC2 A;  3IMJ A;  1XA6 A;  2VIF A;  2MK2 A;  1KA6 A;  1O4H A;  2LQW A;  2FO0 A;  3CXL A;  2PLE A;  3WA4 A;  2CR4 A;  3N7Y A;  1Z3K A;  1R1Q A;  1SHD A;  1O49 A;  1X6C A;  3VS0 A;  3VGO A;  1OO4 A;  1K9A A;  2C0I A;  1SKJ A;  1O4A A;  1YVL A;  1GRI A;  1O42 A;  4X6S A;  3PSK A;  2MC1 A;  2EU0 A;  2EYY A;  2RMX A;  1SPR A;  1LCJ A;  1LUN A;  4K2R A;  4DGP A;  1A09 A;  1QCF A;  2CI8 A;  4P9V A;  2PLD A;  1BF5 A;  1AYB A;  1O4F A;  1JU5 A;  5AXI A;  1AYC A;  2AOA A;  4A4B A;  2Y1M A;  1X27 A;  1AD5 A;  3EAZ A;  4A4C A;  3ZNI A;  4QSY A;  1D1Z A;  1OPK A;  1BHH A;  1LKK A;  1CWE A;  3VS4 A;  1BKM A;  3UYO A;  2EOB A;  4LUE A;  3VRR A;  2ETZ A;  3PJP A;  4OHD A;  4NWG A;  1NZV A;  2IUH A;  1O46 A;  4EY0 A;  2CI9 A;  2L6K A;  3BUM B;  1O43 A;  2EYZ A;  1O47 A;  4XZ0 A;  5GJI A;  5EHP A;  4OHI A;  1FBV A;  5DC0 B;  5DF6 A;  3VS3 A;  1O4E A;  1R1S A;  1M27 A;  5IBS A;  3VRP A;  1O4D A;  2XP1 A;  2QMS A;  3N84 A;  2L3T A;  1JYR A;  1CSY A;  1BKL A;  1G83 A;  1HCS B;  3S8N A;  2C0T A;  3NHN A;  1IJR A;  1BFJ A;  3CD3 A;  4EIH A;  3VS7 A;  3CBL A;  3EAC A;  1B47 A;  2H5K A;  2DLZ A;  1O4Q A;  3OP0 A;  3VRQ A;  2AOB A;  4NWF A;  1H9O A;  5I6V A;  3CWG A;  4F5B A;  4DGX A;  3MXY A;  4JE4 A;  2DVJ A;  2MQI A;  1BM2 A;  2Y1N A;  1TZE E;  3MXC A;  1YVH A;  1LKL A;  3VRZ A;  1F2F A;  1A1E A;  3BUW B;  3PSJ A;  2EKX A;  1JYQ A;  5GJH A;  5EEQ A;  2IUG A;  1MIL A;  2LNW A;  3T04 A;  3PS5 A;  1CJ1 A;  1FU5 A;  3S9K A;  4E93 A;  4GPL B;  2DCR A;  3UF4 A;  4L1B B;  2PNB A;  1O4R A;  2BBU A;  1AB2 A;  3VS5 A;  1NZL A;  2C9W A;  1LUK A;  4GWF A;  2C0O A;  1O4K A;  1SPS A;  1FBZ A;  1RJA A;  2HDV A;  1ZFP E;  5J3X A;  2FCI A;  5HKZ A;  1BLJ A;  3PFV A;  1QG1 E;  1F1W A;  4JGH A;  2ROR A;  1UUR A;  2LCT A;  1AOT F;  2L4K A;  4M4Z A;  4E68 A;  1OPL A;  1SHA A;  3GXX A;  3PQZ A;  1LUI A;  2H8H A;  1O4C A;  3VS1 A;  5BO4 A;  5HKY A;  3VRY A;  1BG1 A;  5IBM A;  4K11 A;  1QAD A;  3S8L A;  3BKB A;  2H46 E;  2KK6 A;  1D4T A;  1TCE A;  2DM0 A;  1P13 A;  2DX0 A;  2ABL A;  3US4 A;  1LUM A;  3VRO A;  2RVF A;  1PIC A;  1O4J A;  4ROJ A;  2YSX A;  1FHS A;  3TL0 A;  2PNA A;  1A1B A;  4XZ1 A;  3BUN B;  1KA7 A;  1JWO A;  3KFJ A;  3PLF B;  3IN7 A;  1JYU A;  2MRK A;  1IS0 A;  1FMK A;  4FL2 A;  2RSY A;  2MRJ A;  1BFI A;  2OZO A;  2CIA A;  3C7I A;  3OV1 A;  3GXW A;  1A08 A;  3QWX X;  1FU6 A;  1O41 A;  2DLY A;  4OHH A;  1LCK A;  3VRN A;  5DC4 A;  4GL9 E;  1O44 A;  1Y57 A;  2HMH A;  1O4M A; 
#chains in the Genus database with same CATH topology
 1CWD L;  2EL8 A;  4TZI A;  2LQN A;  3BUX B;  1O4N A;  3K2M A;  1BHH B;  5AUL A;  3HIZ B;  1O4B A;  1FYR A;  4OHE A;  4OHL A;  2IZV A;  4LUD A;  2CBL A;  1O4O A;  2SRC A;  4H1O A;  1I3Z A;  4U17 A;  1A1A A;  3OB2 B;  2LNX A;  4K44 A;  3OB1 B;  1A1C A;  2Y3A B;  1UUS A;  1SHB A;  1KSW A;  2YU7 A;  4K45 A;  3S8O A;  1D4W A;  2GE9 A;  1X0N A;  1MW4 A;  5EHR A;  4F5A A;  1BHF A;  1AOU F;  1CSZ A;  2GSB A;  5HKW A;  2EO6 A;  2EO3 A;  3VS6 A;  3QWY A;  3OVE A;  1RQQ C;  4WWQ A;  1A81 A;  4FL3 A;  3BUO B;  1M61 A;  1O4L A;  2CRH A;  2HDX A;  3IMD A;  3HCK A;  3M7F A;  1O48 A;  4FBN A;  5CDW A;  2K7A B;  3GQI B;  2K79 B;  5EG3 B;  1O4P A;  4D8K A;  5KAZ A;  1BMB A;  1R1P A;  1HCT B;  2JYQ A;  1O4G A;  2SHP A;  3VS2 A;  3IN8 A;  2PTK A;  5DC9 A;  2ECD A;  1NRV A;  1WQU A;  1GHU A;  2B3O A;  1AYA A;  2HUW A;  1O45 A;  2EYV A;  3N8M A;  1AYD A;  1O4I A;  1OO3 A;  4H34 A;  3MAZ A;  4U1P A;  5EEL A;  3K2T A;  4P9Z A;  2AUG A;  1Y1U A;  1A07 A;  5D0J A;  2IUI A;  1RPY A;  4JEG A;  2LRA A;  2CS0 A;  2HCK A;  1BLK A;  2OQ1 A;  3HHM B;  3TKZ A;  2KNO A;  4F59 A;  1KC2 A;  3IMJ A;  3LYV A;  1XA6 A;  2VIF A;  2MK2 A;  1KA6 A;  1O4H A;  2LQW A;  2FO0 A;  3CXL A;  2PLE A;  3WA4 A;  2CR4 A;  3N7Y A;  1Z3K A;  1R1Q A;  1SHD A;  1O49 A;  1X6C A;  3VS0 A;  3VGO A;  1OO4 A;  1K9A A;  2C0I A;  1SKJ A;  1O4A A;  1YVL A;  1GRI A;  1O42 A;  4X6S A;  3PSK A;  2MC1 A;  2EU0 A;  2EYY A;  2RMX A;  1SPR A;  1LCJ A;  1LUN A;  4K2R A;  4DGP A;  1A09 A;  1QCF A;  2CI8 A;  4P9V A;  2PLD A;  1BF5 A;  1AYB A;  1O4F A;  1JU5 A;  5AXI A;  1AYC A;  2AOA A;  4A4B A;  2Y1M A;  1X27 A;  1AD5 A;  3EAZ A;  4A4C A;  3ZNI A;  4QSY A;  1D1Z A;  1OPK A;  1BHH A;  1LKK A;  1CWE A;  3VS4 A;  1BKM A;  3UYO A;  2EOB A;  4LUE A;  3VRR A;  2ETZ A;  3PJP A;  4OHD A;  4NWG A;  1NZV A;  2IUH A;  1O46 A;  4EY0 A;  2CI9 A;  2L6K A;  3BUM B;  1O43 A;  2EYZ A;  1O47 A;  4XZ0 A;  5GJI A;  5EHP A;  4OHI A;  1FBV A;  5DC0 B;  5DF6 A;  3VS3 A;  1O4E A;  1R1S A;  1M27 A;  5IBS A;  3VRP A;  1O4D A;  2XP1 A;  2QMS A;  3N84 A;  2L3T A;  1JYR A;  1CSY A;  1BKL A;  1G83 A;  1HCS B;  3S8N A;  2C0T A;  3NHN A;  1IJR A;  1BFJ A;  3CD3 A;  4EIH A;  3VS7 A;  3CBL A;  3EAC A;  1B47 A;  2H5K A;  2DLZ A;  1O4Q A;  3OP0 A;  3VRQ A;  2AOB A;  4NWF A;  1H9O A;  5I6V A;  3CWG A;  4F5B A;  4DGX A;  3MXY A;  4JE4 A;  2DVJ A;  2MQI A;  1BM2 A;  2Y1N A;  1TZE E;  3MXC A;  1YVH A;  1LKL A;  3VRZ A;  1F2F A;  1A1E A;  3BUW B;  3PSJ A;  2EKX A;  1JYQ A;  5GJH A;  5EEQ A;  2IUG A;  1MIL A;  2LNW A;  3T04 A;  3PS5 A;  1CJ1 A;  1FU5 A;  3S9K A;  4E93 A;  4GPL B;  2DCR A;  3UF4 A;  4L1B B;  2PNB A;  1O4R A;  2BBU A;  1AB2 A;  3VS5 A;  1NZL A;  2C9W A;  1LUK A;  4GWF A;  2C0O A;  2KGY A;  1O4K A;  1SPS A;  1FBZ A;  1RJA A;  2HDV A;  1ZFP E;  5J3X A;  2FCI A;  5HKZ A;  1BLJ A;  3PFV A;  1QG1 E;  1F1W A;  4JGH A;  2ROR A;  1UUR A;  2LCT A;  1AOT F;  2L4K A;  4M4Z A;  4E68 A;  1OPL A;  1SHA A;  3GXX A;  3PQZ A;  1LUI A;  2H8H A;  1O4C A;  3VS1 A;  5BO4 A;  5HKY A;  3VRY A;  1BG1 A;  5IBM A;  4K11 A;  1QAD A;  3S8L A;  3BKB A;  2H46 E;  2KK6 A;  1D4T A;  1TCE A;  2DM0 A;  1P13 A;  2DX0 A;  2ABL A;  3US4 A;  1LUM A;  3VRO A;  2RVF A;  1PIC A;  1O4J A;  4ROJ A;  2YSX A;  1FHS A;  3TL0 A;  2PNA A;  1A1B A;  4XZ1 A;  3BUN B;  1KA7 A;  1JWO A;  3KFJ A;  3PLF B;  3IN7 A;  1JYU A;  2MRK A;  1IS0 A;  1FMK A;  4FL2 A;  2RSY A;  2MRJ A;  1BFI A;  2OZO A;  2CIA A;  3C7I A;  3OV1 A;  3GXW A;  1A08 A;  3QWX X;  1FU6 A;  1O41 A;  2DLY A;  4OHH A;  1LCK A;  3VRN A;  5DC4 A;  4GL9 E;  1O44 A;  1Y57 A;  2HMH A;  1O4M A; 
#chains in the Genus database with same CATH homology
 1CWD L;  2EL8 A;  4TZI A;  2LQN A;  3BUX B;  1O4N A;  3K2M A;  1BHH B;  5AUL A;  3HIZ B;  1O4B A;  1FYR A;  4OHE A;  4OHL A;  2IZV A;  4LUD A;  2CBL A;  1O4O A;  2SRC A;  4H1O A;  1I3Z A;  4U17 A;  1A1A A;  3OB2 B;  2LNX A;  4K44 A;  3OB1 B;  1A1C A;  2Y3A B;  1UUS A;  1SHB A;  1KSW A;  2YU7 A;  4K45 A;  3S8O A;  1D4W A;  2GE9 A;  1X0N A;  1MW4 A;  5EHR A;  4F5A A;  1BHF A;  1AOU F;  1CSZ A;  2GSB A;  5HKW A;  2EO6 A;  2EO3 A;  3VS6 A;  3QWY A;  3OVE A;  1RQQ C;  4WWQ A;  1A81 A;  4FL3 A;  3BUO B;  1M61 A;  1O4L A;  2CRH A;  2HDX A;  3IMD A;  3HCK A;  3M7F A;  1O48 A;  4FBN A;  5CDW A;  2K7A B;  3GQI B;  2K79 B;  5EG3 B;  1O4P A;  4D8K A;  5KAZ A;  1BMB A;  1R1P A;  1HCT B;  2JYQ A;  1O4G A;  2SHP A;  3VS2 A;  3IN8 A;  2PTK A;  5DC9 A;  2ECD A;  1NRV A;  1WQU A;  1GHU A;  2B3O A;  1AYA A;  2HUW A;  1O45 A;  2EYV A;  3N8M A;  1AYD A;  1O4I A;  1OO3 A;  4H34 A;  3MAZ A;  4U1P A;  5EEL A;  4P9Z A;  2AUG A;  1Y1U A;  1A07 A;  5D0J A;  2IUI A;  1RPY A;  4JEG A;  2CS0 A;  2HCK A;  1BLK A;  2OQ1 A;  3HHM B;  3TKZ A;  2KNO A;  4F59 A;  1KC2 A;  3IMJ A;  1XA6 A;  2VIF A;  2MK2 A;  1KA6 A;  1O4H A;  2LQW A;  2FO0 A;  3CXL A;  2PLE A;  3WA4 A;  2CR4 A;  3N7Y A;  1Z3K A;  1R1Q A;  1SHD A;  1O49 A;  1X6C A;  3VS0 A;  3VGO A;  1OO4 A;  1K9A A;  2C0I A;  1SKJ A;  1O4A A;  1YVL A;  1GRI A;  1O42 A;  4X6S A;  3PSK A;  2MC1 A;  2EU0 A;  2EYY A;  2RMX A;  1SPR A;  1LCJ A;  1LUN A;  4K2R A;  4DGP A;  1A09 A;  1QCF A;  2CI8 A;  4P9V A;  2PLD A;  1BF5 A;  1AYB A;  1O4F A;  1JU5 A;  5AXI A;  1AYC A;  2AOA A;  4A4B A;  2Y1M A;  1X27 A;  1AD5 A;  3EAZ A;  4A4C A;  3ZNI A;  4QSY A;  1D1Z A;  1OPK A;  1BHH A;  1LKK A;  1CWE A;  3VS4 A;  1BKM A;  3UYO A;  2EOB A;  4LUE A;  3VRR A;  2ETZ A;  3PJP A;  4OHD A;  4NWG A;  1NZV A;  2IUH A;  1O46 A;  4EY0 A;  2CI9 A;  2L6K A;  3BUM B;  1O43 A;  2EYZ A;  1O47 A;  4XZ0 A;  5GJI A;  5EHP A;  4OHI A;  1FBV A;  5DC0 B;  5DF6 A;  3VS3 A;  1O4E A;  1R1S A;  1M27 A;  5IBS A;  3VRP A;  1O4D A;  2XP1 A;  2QMS A;  3N84 A;  2L3T A;  1JYR A;  1CSY A;  1BKL A;  1G83 A;  1HCS B;  3S8N A;  2C0T A;  3NHN A;  1IJR A;  1BFJ A;  3CD3 A;  4EIH A;  3VS7 A;  3CBL A;  3EAC A;  1B47 A;  2H5K A;  2DLZ A;  1O4Q A;  3OP0 A;  3VRQ A;  2AOB A;  4NWF A;  1H9O A;  5I6V A;  3CWG A;  4F5B A;  4DGX A;  3MXY A;  4JE4 A;  2DVJ A;  2MQI A;  1BM2 A;  2Y1N A;  1TZE E;  3MXC A;  1YVH A;  1LKL A;  3VRZ A;  1F2F A;  1A1E A;  3BUW B;  3PSJ A;  2EKX A;  1JYQ A;  5GJH A;  5EEQ A;  2IUG A;  1MIL A;  2LNW A;  3T04 A;  3PS5 A;  1CJ1 A;  1FU5 A;  3S9K A;  4E93 A;  4GPL B;  2DCR A;  3UF4 A;  4L1B B;  2PNB A;  1O4R A;  2BBU A;  1AB2 A;  3VS5 A;  1NZL A;  2C9W A;  1LUK A;  4GWF A;  2C0O A;  1O4K A;  1SPS A;  1FBZ A;  1RJA A;  2HDV A;  1ZFP E;  5J3X A;  2FCI A;  5HKZ A;  1BLJ A;  3PFV A;  1QG1 E;  1F1W A;  4JGH A;  2ROR A;  1UUR A;  2LCT A;  1AOT F;  2L4K A;  4M4Z A;  4E68 A;  1OPL A;  1SHA A;  3GXX A;  3PQZ A;  1LUI A;  2H8H A;  1O4C A;  3VS1 A;  5BO4 A;  5HKY A;  3VRY A;  1BG1 A;  5IBM A;  4K11 A;  1QAD A;  3S8L A;  3BKB A;  2H46 E;  2KK6 A;  1D4T A;  1TCE A;  2DM0 A;  1P13 A;  2DX0 A;  2ABL A;  3US4 A;  1LUM A;  3VRO A;  2RVF A;  1PIC A;  1O4J A;  4ROJ A;  2YSX A;  1FHS A;  3TL0 A;  2PNA A;  1A1B A;  4XZ1 A;  3BUN B;  1KA7 A;  1JWO A;  3KFJ A;  3PLF B;  3IN7 A;  1JYU A;  2MRK A;  1IS0 A;  1FMK A;  4FL2 A;  2RSY A;  2MRJ A;  1BFI A;  2OZO A;  2CIA A;  3C7I A;  3OV1 A;  3GXW A;  1A08 A;  3QWX X;  1FU6 A;  1O41 A;  2DLY A;  4OHH A;  1LCK A;  3VRN A;  5DC4 A;  4GL9 E;  1O44 A;  1Y57 A;  2HMH A;  1O4M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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