1O48A

Crystal structure of sh2 in complex with ru85053.
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
106
structure length
106
Chain Sequence
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
total genus 25
structure length 106
sequence length 106
ec nomenclature ec 2.7.10.2: Non-specific protein-tyrosine kinase.
pdb deposition date 2003-06-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 1o48A00
2MK2A 3VS6A 4NWGA 2RMXA 2CI9A 4D8KA 1FBVA 1A07A 1TCEA 2L6KA 1A1AA 1UUSA 1QG1E 1CSYA 2HUWA 3CXLA 1IJRA 2Y1NA 5BO4A 4FBNA 3S9KA 1KA6A 2EYVA 3K2MA 2IUGA 1O4OA 4DGXA 1O46A 3BUOB 1JYUA 1M27A 3GQIB 3OB1B 2C9WA 1A1BA 1O4EA 4K45A 2LNXA 4E93A 1R1SA 1FBZA 1IS0A 2CBLA 4X6SA 4GPLB 1O42A 1Z3KA 3S8LA 3VROA 3BUMB 1CWEA 1SHBA 1D4TA 2DX0A 4U17A 1AD5A 2C0IA 2FCIA 1JYRA 2KNOA 3GXXA 1AOTF 3N7YA 1AYAA 3VRNA 4OHDA 3US4A 1X27A 1A08A 2GE9A 3BKBA 1BF5A 3PQZA 4F59A 2DLYA 1FYRA 3IMDA 3VRYA 4JE4A 4ROJA 2MQIA 2PLEA 1I3ZA 4OHIA 1PICA 1SKJA 1LUKA 1WQUA 3UYOA 1HCTB 3BUXB 3VS4A 2EU0A 2BBUA 4JGHA 1BMBA 4QSYA 1KSWA 1O43A 2ECDA 2PNAA 1LUNA 3VS3A 4FL3A 1FU5A 3C7IA 1B47A 1R1PA 3HIZB 1O4JA 2MC1A 5DC4A 1LUIA 1QCFA 4NWFA 5HKWA 1BM2A 5HKYA 2ABLA 1UURA 1O4FA 1QADA 1FU6A 4H1OA 1GRIA 5GJIA 3HCKA 1O4KA 1O4IA 5AXIA 1BHHA 2EL8A 1BHFA 2CI8A 2RSYA 2EYZA 5EELA 3PJPA 2PNBA 4LUEA 5IBMA 1O4LA 3KFJA 3T04A 2RVFA 1JWOA 2HMHA 3PSKA 1O4QA 1X6CA 1O4GA 4K11A 2LCTA 5EG3B 4A4CA 1CJ1A 4U1PA 4A4BA 3VS2A 4FL2A 3M7FA 1BLKA 3PS5A 3HHMB 4LUDA 3CD3A 4OHLA 1Y1UA 3EACA 1K9AA 1HCSB 3QWYA 1O4AA 1H9OA 3VS1A 2EOBA 3MAZA 1O47A 1A81A 3CBLA 2VIFA 2DM0A 2FO0A 3MXCA 2RORA 4L1BB 1OPKA 4P9VA 3VRRA 2SRCA 1AYDA 1O4NA 2AOBA 1BKMA 3S8NA 3VRPA 3MXYA 2MRJA 2OZOA 1FHSA 2C0OA 1D1ZA 2HCKA 1RQQC 1M61A 3CWGA 4TZIA 2SHPA 4GL9E 5HKZA 2KK6A 2K7AB 1O4CA 2EO6A 2L4KA 4WWQA 2GSBA 1OO4A 4XZ1A 5KAZA 1BG1A 3NHNA 1YVHA 3VGOA 1Y57A 2HDVA 1CSZA 1A09A 1ZFPE 1RJAA 1O49A 2DLZA 1O44A 4EY0A 2CS0A 3EAZA 1KC2A 3OV1A 2EO3A 1O48A 2XP1A 1CWDL 1OO3A 1NZVA 1JYQA 2ETZA 1AOUF 4GWFA 1A1EA 5DF6A 3TL0A 2H8HA 1AYBA 3ZNIA 4DGPA 5D0JA 3BUWB 3OVEA 1O4RA 2MRKA 4OHHA 1SHAA 2EYYA 1NZLA 3OB2B 1LCJA 2QMSA 2CR4A 4OHEA 1BHHB 3GXWA 2HDXA 1BKLA 1O4DA 2Y1MA 2EKXA 2OQ1A 3N8MA 2LQNA 5AULA 1YVLA 3UF4A 1RPYA 2IUHA 4P9ZA 2L3TA 1KA7A 4JEGA 5GJHA 1F2FA 5EHRA 5EHPA 2YU7A 1X0NA 1BLJA 1SHDA 2CIAA 1MW4A 3IN7A 1LKLA 3PLFB 5J3XA 2YSXA 2K79B 3VRQA 1D4WA 2AUGA 1F1WA 4H34A 2PLDA 2CRHA 2C0TA 1BFJA 2DVJA 4M4ZA 1SPRA 2PTKA 3PFVA 1R1QA 3WA4A 1LKKA 2B3OA 1NRVA 1JU5A 4XZ0A 1XA6A 4F5AA 1P13A 1GHUA 5DC0B 3PSJA 1G83A 1FMKA 1TZEE 2DCRA 3BUNB 3IMJA 4EIHA 2LQWA 3IN8A 5IBSA 1LUMA 5I6VA 3VRZA 2LNWA 1O4BA 3QWXX 4K2RA 5EEQA 3OP0A 1O45A 1LCKA 4K44A 3TKZA 5DC9A 1O4MA 2IZVA 2AOAA 4E68A 2JYQA 1BFIA 3N84A 1AYCA 3VS7A 1MILA 4F5BA 2H5KA 3VS5A 2IUIA 2Y3AB 1O4PA 2H46E 1O4HA 1SPSA 3VS0A 5CDWA 1A1CA 1AB2A 1O41A 3S8OA 1OPLA
chains in the Genus database with same CATH superfamily
2MK2A 3VS6A 4NWGA 2RMXA 2CI9A 4D8KA 1FBVA 1A07A 1TCEA 2L6KA 1A1AA 1UUSA 1QG1E 1CSYA 2HUWA 3CXLA 1IJRA 2Y1NA 5BO4A 4FBNA 3S9KA 1KA6A 2EYVA 3K2MA 2IUGA 1O4OA 4DGXA 1O46A 3BUOB 1JYUA 1M27A 3GQIB 3OB1B 2C9WA 1A1BA 1O4EA 2KGYA 2LNXA 4K45A 4E93A 1R1SA 1FBZA 1IS0A 2CBLA 4X6SA 4GPLB 1O42A 1Z3KA 3S8LA 3VROA 3BUMB 1CWEA 1SHBA 1D4TA 2DX0A 4U17A 1AD5A 2C0IA 2FCIA 1JYRA 2KNOA 3GXXA 1AOTF 3N7YA 1AYAA 3VRNA 4OHDA 3US4A 1X27A 1A08A 2GE9A 3BKBA 1BF5A 3PQZA 4F59A 2DLYA 2LRAA 1FYRA 3IMDA 3VRYA 4JE4A 4ROJA 2MQIA 2PLEA 1I3ZA 4OHIA 1PICA 1SKJA 1LUKA 1WQUA 3UYOA 1HCTB 3BUXB 3VS4A 2EU0A 2BBUA 4JGHA 1BMBA 4QSYA 1KSWA 1O43A 2ECDA 2PNAA 1LUNA 3VS3A 4FL3A 1FU5A 3C7IA 1B47A 1R1PA 3HIZB 1O4JA 2MC1A 5DC4A 1LUIA 1QCFA 4NWFA 5HKWA 1BM2A 5HKYA 2ABLA 1UURA 1O4FA 1QADA 1FU6A 4H1OA 1GRIA 5GJIA 3HCKA 1O4KA 1O4IA 5AXIA 1BHHA 2EL8A 1BHFA 2CI8A 2RSYA 2EYZA 5EELA 3PJPA 2PNBA 4LUEA 5IBMA 1O4LA 3KFJA 3T04A 2RVFA 1JWOA 2HMHA 3PSKA 1O4QA 1X6CA 1O4GA 4K11A 2LCTA 5EG3B 4A4CA 1CJ1A 4U1PA 4A4BA 3VS2A 4FL2A 3M7FA 1BLKA 3PS5A 3HHMB 4LUDA 3CD3A 4OHLA 1Y1UA 3EACA 1K9AA 1HCSB 3QWYA 1O4AA 1H9OA 3VS1A 2EOBA 3MAZA 1O47A 1A81A 3CBLA 2VIFA 2DM0A 2FO0A 3MXCA 2RORA 4L1BB 1OPKA 4P9VA 3VRRA 2SRCA 1AYDA 1O4NA 2AOBA 1BKMA 3S8NA 3VRPA 3MXYA 2MRJA 2OZOA 1FHSA 2C0OA 1D1ZA 2HCKA 1RQQC 1M61A 3CWGA 4TZIA 2SHPA 4GL9E 5HKZA 2KK6A 2K7AB 1O4CA 3K2TA 2EO6A 2L4KA 4WWQA 2GSBA 1OO4A 4XZ1A 5KAZA 1BG1A 3NHNA 1YVHA 3VGOA 1Y57A 2HDVA 1CSZA 1A09A 1ZFPE 1RJAA 1O49A 2DLZA 1O44A 4EY0A 2CS0A 3EAZA 1KC2A 3OV1A 2EO3A 1O48A 2XP1A 1CWDL 1OO3A 1NZVA 1JYQA 2ETZA 1AOUF 4GWFA 1A1EA 5DF6A 3TL0A 2H8HA 1AYBA 3ZNIA 4DGPA 5D0JA 3BUWB 3LYVA 3OVEA 1O4RA 2MRKA 4OHHA 1SHAA 2EYYA 1NZLA 3OB2B 1LCJA 2QMSA 2CR4A 4OHEA 1BHHB 3GXWA 2HDXA 1BKLA 1O4DA 2Y1MA 2EKXA 2OQ1A 3N8MA 2LQNA 5AULA 1YVLA 3UF4A 1RPYA 2IUHA 4P9ZA 2L3TA 1KA7A 4JEGA 5GJHA 1F2FA 5EHRA 5EHPA 2YU7A 1X0NA 1BLJA 1SHDA 2CIAA 1MW4A 3IN7A 1LKLA 3PLFB 5J3XA 2YSXA 2K79B 3VRQA 1D4WA 2AUGA 1F1WA 4H34A 2PLDA 2CRHA 2C0TA 1BFJA 2DVJA 4M4ZA 1SPRA 2PTKA 3PFVA 1R1QA 3WA4A 1LKKA 2B3OA 1NRVA 1JU5A 4XZ0A 1XA6A 4F5AA 1P13A 1GHUA 5DC0B 3PSJA 1G83A 1FMKA 1TZEE 2DCRA 3BUNB 3IMJA 4EIHA 2LQWA 3IN8A 5IBSA 1LUMA 5I6VA 3VRZA 2LNWA 1O4BA 3QWXX 4K2RA 5EEQA 3OP0A 1O45A 1LCKA 4K44A 3TKZA 5DC9A 1O4MA 2IZVA 2AOAA 4E68A 2JYQA 1BFIA 3N84A 1AYCA 3VS7A 1MILA 4F5BA 2H5KA 3VS5A 2IUIA 2Y3AB 1O4PA 2H46E 1O4HA 1SPSA 3VS0A 5CDWA 1A1CA 1AB2A 1O41A 3S8OA 1OPLA
chains in the Genus database with same CATH topology
2MK2A 3VS6A 4NWGA 2RMXA 2CI9A 4D8KA 1FBVA 1A07A 1TCEA 2L6KA 1A1AA 1UUSA 1QG1E 1CSYA 2HUWA 3CXLA 1IJRA 2Y1NA 5BO4A 4FBNA 3S9KA 1KA6A 2EYVA 3K2MA 2IUGA 1O4OA 4DGXA 1O46A 3BUOB 1JYUA 1M27A 3GQIB 3OB1B 2C9WA 1A1BA 1O4EA 4K45A 2LNXA 4E93A 1R1SA 1FBZA 1IS0A 2CBLA 4X6SA 4GPLB 1O42A 1Z3KA 3S8LA 3VROA 3BUMB 1CWEA 1SHBA 1D4TA 2DX0A 4U17A 1AD5A 2C0IA 2FCIA 1JYRA 2KNOA 3GXXA 1AOTF 3N7YA 1AYAA 3VRNA 4OHDA 3US4A 1X27A 1A08A 2GE9A 3BKBA 1BF5A 3PQZA 4F59A 2DLYA 1FYRA 3IMDA 3VRYA 4JE4A 4ROJA 2MQIA 2PLEA 1I3ZA 4OHIA 1PICA 1SKJA 1LUKA 1WQUA 3UYOA 1HCTB 3BUXB 3VS4A 2EU0A 2BBUA 4JGHA 1BMBA 4QSYA 1KSWA 1O43A 2ECDA 2PNAA 1LUNA 3VS3A 4FL3A 1FU5A 3C7IA 1B47A 1R1PA 3HIZB 1O4JA 2MC1A 5DC4A 1LUIA 1QCFA 4NWFA 5HKWA 1BM2A 5HKYA 2ABLA 1UURA 1O4FA 1QADA 1FU6A 4H1OA 1GRIA 5GJIA 3HCKA 1O4KA 1O4IA 5AXIA 1BHHA 2EL8A 1BHFA 2CI8A 2RSYA 2EYZA 5EELA 3PJPA 2PNBA 4LUEA 5IBMA 1O4LA 3KFJA 3T04A 2RVFA 1JWOA 2HMHA 3PSKA 1O4QA 1X6CA 1O4GA 4K11A 2LCTA 5EG3B 4A4CA 1CJ1A 4U1PA 4A4BA 3VS2A 4FL2A 3M7FA 1BLKA 3PS5A 3HHMB 4LUDA 3CD3A 4OHLA 1Y1UA 3EACA 1K9AA 1HCSB 3QWYA 1O4AA 1H9OA 3VS1A 2EOBA 3MAZA 1O47A 1A81A 3CBLA 2VIFA 2DM0A 2FO0A 3MXCA 2RORA 4L1BB 1OPKA 4P9VA 3VRRA 2SRCA 1AYDA 1O4NA 2AOBA 1BKMA 3S8NA 3VRPA 3MXYA 2MRJA 2OZOA 1FHSA 2C0OA 1D1ZA 2HCKA 1RQQC 1M61A 3CWGA 4TZIA 2SHPA 4GL9E 5HKZA 2KK6A 2K7AB 1O4CA 2EO6A 2L4KA 4WWQA 2GSBA 1OO4A 4XZ1A 5KAZA 1BG1A 3NHNA 1YVHA 3VGOA 1Y57A 2HDVA 1CSZA 1A09A 1ZFPE 1RJAA 1O49A 2DLZA 1O44A 4EY0A 2CS0A 3EAZA 1KC2A 3OV1A 2EO3A 1O48A 2XP1A 1CWDL 1OO3A 1NZVA 1JYQA 2ETZA 1AOUF 4GWFA 1A1EA 5DF6A 3TL0A 2H8HA 1AYBA 3ZNIA 4DGPA 5D0JA 3BUWB 3OVEA 1O4RA 2MRKA 4OHHA 1SHAA 2EYYA 1NZLA 3OB2B 1LCJA 2QMSA 2CR4A 4OHEA 1BHHB 3GXWA 2HDXA 1BKLA 1O4DA 2Y1MA 2EKXA 2OQ1A 3N8MA 2LQNA 5AULA 1YVLA 3UF4A 1RPYA 2IUHA 4P9ZA 2L3TA 1KA7A 4JEGA 5GJHA 1F2FA 5EHRA 5EHPA 2YU7A 1X0NA 1BLJA 1SHDA 2CIAA 1MW4A 3IN7A 1LKLA 3PLFB 5J3XA 2YSXA 2K79B 3VRQA 1D4WA 2AUGA 1F1WA 4H34A 2PLDA 2CRHA 2C0TA 1BFJA 2DVJA 4M4ZA 1SPRA 2PTKA 3PFVA 1R1QA 3WA4A 1LKKA 2B3OA 1NRVA 1JU5A 4XZ0A 1XA6A 4F5AA 1P13A 1GHUA 5DC0B 3PSJA 1G83A 1FMKA 1TZEE 2DCRA 3BUNB 3IMJA 4EIHA 2LQWA 3IN8A 5IBSA 1LUMA 5I6VA 3VRZA 2LNWA 1O4BA 3QWXX 4K2RA 5EEQA 3OP0A 1O45A 1LCKA 4K44A 3TKZA 5DC9A 1O4MA 2IZVA 2AOAA 4E68A 2JYQA 1BFIA 3N84A 1AYCA 3VS7A 1MILA 4F5BA 2H5KA 3VS5A 2IUIA 2Y3AB 1O4PA 2H46E 1O4HA 1SPSA 3VS0A 5CDWA 1A1CA 1AB2A 1O41A 3S8OA 1OPLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MK2 A;  3VS6 A;  4NWG A;  2RMX A;  2CI9 A;  4D8K A;  1FBV A;  1A07 A;  1TCE A;  2L6K A;  1A1A A;  1UUS A;  1QG1 E;  1CSY A;  2HUW A;  3CXL A;  1IJR A;  2Y1N A;  5BO4 A;  4FBN A;  3S9K A;  1KA6 A;  2EYV A;  3K2M A;  2IUG A;  1O4O A;  4DGX A;  1O46 A;  3BUO B;  1JYU A;  1M27 A;  3GQI B;  3OB1 B;  2C9W A;  1A1B A;  1O4E A;  4K45 A;  2LNX A;  4E93 A;  1R1S A;  1FBZ A;  1IS0 A;  2CBL A;  4X6S A;  4GPL B;  1O42 A;  1Z3K A;  3S8L A;  3VRO A;  3BUM B;  1CWE A;  1SHB A;  1D4T A;  2DX0 A;  4U17 A;  1AD5 A;  2C0I A;  2FCI A;  1JYR A;  2KNO A;  3GXX A;  1AOT F;  3N7Y A;  1AYA A;  3VRN A;  4OHD A;  3US4 A;  1X27 A;  1A08 A;  2GE9 A;  3BKB A;  1BF5 A;  3PQZ A;  4F59 A;  2DLY A;  1FYR A;  3IMD A;  3VRY A;  4JE4 A;  4ROJ A;  2MQI A;  2PLE A;  1I3Z A;  4OHI A;  1PIC A;  1SKJ A;  1LUK A;  1WQU A;  3UYO A;  1HCT B;  3BUX B;  3VS4 A;  2EU0 A;  2BBU A;  4JGH A;  1BMB A;  4QSY A;  1KSW A;  1O43 A;  2ECD A;  2PNA A;  1LUN A;  3VS3 A;  4FL3 A;  1FU5 A;  3C7I A;  1B47 A;  1R1P A;  3HIZ B;  1O4J A;  2MC1 A;  5DC4 A;  1LUI A;  1QCF A;  4NWF A;  5HKW A;  1BM2 A;  5HKY A;  2ABL A;  1UUR A;  1O4F A;  1QAD A;  1FU6 A;  4H1O A;  1GRI A;  5GJI A;  3HCK A;  1O4K A;  1O4I A;  5AXI A;  1BHH A;  2EL8 A;  1BHF A;  2CI8 A;  2RSY A;  2EYZ A;  5EEL A;  3PJP A;  2PNB A;  4LUE A;  5IBM A;  1O4L A;  3KFJ A;  3T04 A;  2RVF A;  1JWO A;  2HMH A;  3PSK A;  1O4Q A;  1X6C A;  1O4G A;  4K11 A;  2LCT A;  5EG3 B;  4A4C A;  1CJ1 A;  4U1P A;  4A4B A;  3VS2 A;  4FL2 A;  3M7F A;  1BLK A;  3PS5 A;  3HHM B;  4LUD A;  3CD3 A;  4OHL A;  1Y1U A;  3EAC A;  1K9A A;  1HCS B;  3QWY A;  1O4A A;  1H9O A;  3VS1 A;  2EOB A;  3MAZ A;  1O47 A;  1A81 A;  3CBL A;  2VIF A;  2DM0 A;  2FO0 A;  3MXC A;  2ROR A;  4L1B B;  1OPK A;  4P9V A;  3VRR A;  2SRC A;  1AYD A;  1O4N A;  2AOB A;  1BKM A;  3S8N A;  3VRP A;  3MXY A;  2MRJ A;  2OZO A;  1FHS A;  2C0O A;  1D1Z A;  2HCK A;  1RQQ C;  1M61 A;  3CWG A;  4TZI A;  2SHP A;  4GL9 E;  5HKZ A;  2KK6 A;  2K7A B;  1O4C A;  2EO6 A;  2L4K A;  4WWQ A;  2GSB A;  1OO4 A;  4XZ1 A;  5KAZ A;  1BG1 A;  3NHN A;  1YVH A;  3VGO A;  1Y57 A;  2HDV A;  1CSZ A;  1A09 A;  1ZFP E;  1RJA A;  1O49 A;  2DLZ A;  1O44 A;  4EY0 A;  2CS0 A;  3EAZ A;  1KC2 A;  3OV1 A;  2EO3 A;  1O48 A;  2XP1 A;  1CWD L;  1OO3 A;  1NZV A;  1JYQ A;  2ETZ A;  1AOU F;  4GWF A;  1A1E A;  5DF6 A;  3TL0 A;  2H8H A;  1AYB A;  3ZNI A;  4DGP A;  5D0J A;  3BUW B;  3OVE A;  1O4R A;  2MRK A;  4OHH A;  1SHA A;  2EYY A;  1NZL A;  3OB2 B;  1LCJ A;  2QMS A;  2CR4 A;  4OHE A;  1BHH B;  3GXW A;  2HDX A;  1BKL A;  1O4D A;  2Y1M A;  2EKX A;  2OQ1 A;  3N8M A;  2LQN A;  5AUL A;  1YVL A;  3UF4 A;  1RPY A;  2IUH A;  4P9Z A;  2L3T A;  1KA7 A;  4JEG A;  5GJH A;  1F2F A;  5EHR A;  5EHP A;  2YU7 A;  1X0N A;  1BLJ A;  1SHD A;  2CIA A;  1MW4 A;  3IN7 A;  1LKL A;  3PLF B;  5J3X A;  2YSX A;  2K79 B;  3VRQ A;  1D4W A;  2AUG A;  1F1W A;  4H34 A;  2PLD A;  2CRH A;  2C0T A;  1BFJ A;  2DVJ A;  4M4Z A;  1SPR A;  2PTK A;  3PFV A;  1R1Q A;  3WA4 A;  1LKK A;  2B3O A;  1NRV A;  1JU5 A;  4XZ0 A;  1XA6 A;  4F5A A;  1P13 A;  1GHU A;  5DC0 B;  3PSJ A;  1G83 A;  1FMK A;  1TZE E;  2DCR A;  3BUN B;  3IMJ A;  4EIH A;  2LQW A;  3IN8 A;  5IBS A;  1LUM A;  5I6V A;  3VRZ A;  2LNW A;  1O4B A;  3QWX X;  4K2R A;  5EEQ A;  3OP0 A;  1O45 A;  1LCK A;  4K44 A;  3TKZ A;  5DC9 A;  1O4M A;  2IZV A;  2AOA A;  4E68 A;  2JYQ A;  1BFI A;  3N84 A;  1AYC A;  3VS7 A;  1MIL A;  4F5B A;  2H5K A;  3VS5 A;  2IUI A;  2Y3A B;  1O4P A;  2H46 E;  1O4H A;  1SPS A;  3VS0 A;  5CDW A;  1A1C A;  1AB2 A;  1O41 A;  3S8O A;  1OPL A; 
#chains in the Genus database with same CATH topology
 2MK2 A;  3VS6 A;  4NWG A;  2RMX A;  2CI9 A;  4D8K A;  1FBV A;  1A07 A;  1TCE A;  2L6K A;  1A1A A;  1UUS A;  1QG1 E;  1CSY A;  2HUW A;  3CXL A;  1IJR A;  2Y1N A;  5BO4 A;  4FBN A;  3S9K A;  1KA6 A;  2EYV A;  3K2M A;  2IUG A;  1O4O A;  4DGX A;  1O46 A;  3BUO B;  1JYU A;  1M27 A;  3GQI B;  3OB1 B;  2C9W A;  1A1B A;  1O4E A;  2KGY A;  2LNX A;  4K45 A;  4E93 A;  1R1S A;  1FBZ A;  1IS0 A;  2CBL A;  4X6S A;  4GPL B;  1O42 A;  1Z3K A;  3S8L A;  3VRO A;  3BUM B;  1CWE A;  1SHB A;  1D4T A;  2DX0 A;  4U17 A;  1AD5 A;  2C0I A;  2FCI A;  1JYR A;  2KNO A;  3GXX A;  1AOT F;  3N7Y A;  1AYA A;  3VRN A;  4OHD A;  3US4 A;  1X27 A;  1A08 A;  2GE9 A;  3BKB A;  1BF5 A;  3PQZ A;  4F59 A;  2DLY A;  2LRA A;  1FYR A;  3IMD A;  3VRY A;  4JE4 A;  4ROJ A;  2MQI A;  2PLE A;  1I3Z A;  4OHI A;  1PIC A;  1SKJ A;  1LUK A;  1WQU A;  3UYO A;  1HCT B;  3BUX B;  3VS4 A;  2EU0 A;  2BBU A;  4JGH A;  1BMB A;  4QSY A;  1KSW A;  1O43 A;  2ECD A;  2PNA A;  1LUN A;  3VS3 A;  4FL3 A;  1FU5 A;  3C7I A;  1B47 A;  1R1P A;  3HIZ B;  1O4J A;  2MC1 A;  5DC4 A;  1LUI A;  1QCF A;  4NWF A;  5HKW A;  1BM2 A;  5HKY A;  2ABL A;  1UUR A;  1O4F A;  1QAD A;  1FU6 A;  4H1O A;  1GRI A;  5GJI A;  3HCK A;  1O4K A;  1O4I A;  5AXI A;  1BHH A;  2EL8 A;  1BHF A;  2CI8 A;  2RSY A;  2EYZ A;  5EEL A;  3PJP A;  2PNB A;  4LUE A;  5IBM A;  1O4L A;  3KFJ A;  3T04 A;  2RVF A;  1JWO A;  2HMH A;  3PSK A;  1O4Q A;  1X6C A;  1O4G A;  4K11 A;  2LCT A;  5EG3 B;  4A4C A;  1CJ1 A;  4U1P A;  4A4B A;  3VS2 A;  4FL2 A;  3M7F A;  1BLK A;  3PS5 A;  3HHM B;  4LUD A;  3CD3 A;  4OHL A;  1Y1U A;  3EAC A;  1K9A A;  1HCS B;  3QWY A;  1O4A A;  1H9O A;  3VS1 A;  2EOB A;  3MAZ A;  1O47 A;  1A81 A;  3CBL A;  2VIF A;  2DM0 A;  2FO0 A;  3MXC A;  2ROR A;  4L1B B;  1OPK A;  4P9V A;  3VRR A;  2SRC A;  1AYD A;  1O4N A;  2AOB A;  1BKM A;  3S8N A;  3VRP A;  3MXY A;  2MRJ A;  2OZO A;  1FHS A;  2C0O A;  1D1Z A;  2HCK A;  1RQQ C;  1M61 A;  3CWG A;  4TZI A;  2SHP A;  4GL9 E;  5HKZ A;  2KK6 A;  2K7A B;  1O4C A;  3K2T A;  2EO6 A;  2L4K A;  4WWQ A;  2GSB A;  1OO4 A;  4XZ1 A;  5KAZ A;  1BG1 A;  3NHN A;  1YVH A;  3VGO A;  1Y57 A;  2HDV A;  1CSZ A;  1A09 A;  1ZFP E;  1RJA A;  1O49 A;  2DLZ A;  1O44 A;  4EY0 A;  2CS0 A;  3EAZ A;  1KC2 A;  3OV1 A;  2EO3 A;  1O48 A;  2XP1 A;  1CWD L;  1OO3 A;  1NZV A;  1JYQ A;  2ETZ A;  1AOU F;  4GWF A;  1A1E A;  5DF6 A;  3TL0 A;  2H8H A;  1AYB A;  3ZNI A;  4DGP A;  5D0J A;  3BUW B;  3LYV A;  3OVE A;  1O4R A;  2MRK A;  4OHH A;  1SHA A;  2EYY A;  1NZL A;  3OB2 B;  1LCJ A;  2QMS A;  2CR4 A;  4OHE A;  1BHH B;  3GXW A;  2HDX A;  1BKL A;  1O4D A;  2Y1M A;  2EKX A;  2OQ1 A;  3N8M A;  2LQN A;  5AUL A;  1YVL A;  3UF4 A;  1RPY A;  2IUH A;  4P9Z A;  2L3T A;  1KA7 A;  4JEG A;  5GJH A;  1F2F A;  5EHR A;  5EHP A;  2YU7 A;  1X0N A;  1BLJ A;  1SHD A;  2CIA A;  1MW4 A;  3IN7 A;  1LKL A;  3PLF B;  5J3X A;  2YSX A;  2K79 B;  3VRQ A;  1D4W A;  2AUG A;  1F1W A;  4H34 A;  2PLD A;  2CRH A;  2C0T A;  1BFJ A;  2DVJ A;  4M4Z A;  1SPR A;  2PTK A;  3PFV A;  1R1Q A;  3WA4 A;  1LKK A;  2B3O A;  1NRV A;  1JU5 A;  4XZ0 A;  1XA6 A;  4F5A A;  1P13 A;  1GHU A;  5DC0 B;  3PSJ A;  1G83 A;  1FMK A;  1TZE E;  2DCR A;  3BUN B;  3IMJ A;  4EIH A;  2LQW A;  3IN8 A;  5IBS A;  1LUM A;  5I6V A;  3VRZ A;  2LNW A;  1O4B A;  3QWX X;  4K2R A;  5EEQ A;  3OP0 A;  1O45 A;  1LCK A;  4K44 A;  3TKZ A;  5DC9 A;  1O4M A;  2IZV A;  2AOA A;  4E68 A;  2JYQ A;  1BFI A;  3N84 A;  1AYC A;  3VS7 A;  1MIL A;  4F5B A;  2H5K A;  3VS5 A;  2IUI A;  2Y3A B;  1O4P A;  2H46 E;  1O4H A;  1SPS A;  3VS0 A;  5CDW A;  1A1C A;  1AB2 A;  1O41 A;  3S8O A;  1OPL A; 
#chains in the Genus database with same CATH homology
 2MK2 A;  3VS6 A;  4NWG A;  2RMX A;  2CI9 A;  4D8K A;  1FBV A;  1A07 A;  1TCE A;  2L6K A;  1A1A A;  1UUS A;  1QG1 E;  1CSY A;  2HUW A;  3CXL A;  1IJR A;  2Y1N A;  5BO4 A;  4FBN A;  3S9K A;  1KA6 A;  2EYV A;  3K2M A;  2IUG A;  1O4O A;  4DGX A;  1O46 A;  3BUO B;  1JYU A;  1M27 A;  3GQI B;  3OB1 B;  2C9W A;  1A1B A;  1O4E A;  4K45 A;  2LNX A;  4E93 A;  1R1S A;  1FBZ A;  1IS0 A;  2CBL A;  4X6S A;  4GPL B;  1O42 A;  1Z3K A;  3S8L A;  3VRO A;  3BUM B;  1CWE A;  1SHB A;  1D4T A;  2DX0 A;  4U17 A;  1AD5 A;  2C0I A;  2FCI A;  1JYR A;  2KNO A;  3GXX A;  1AOT F;  3N7Y A;  1AYA A;  3VRN A;  4OHD A;  3US4 A;  1X27 A;  1A08 A;  2GE9 A;  3BKB A;  1BF5 A;  3PQZ A;  4F59 A;  2DLY A;  1FYR A;  3IMD A;  3VRY A;  4JE4 A;  4ROJ A;  2MQI A;  2PLE A;  1I3Z A;  4OHI A;  1PIC A;  1SKJ A;  1LUK A;  1WQU A;  3UYO A;  1HCT B;  3BUX B;  3VS4 A;  2EU0 A;  2BBU A;  4JGH A;  1BMB A;  4QSY A;  1KSW A;  1O43 A;  2ECD A;  2PNA A;  1LUN A;  3VS3 A;  4FL3 A;  1FU5 A;  3C7I A;  1B47 A;  1R1P A;  3HIZ B;  1O4J A;  2MC1 A;  5DC4 A;  1LUI A;  1QCF A;  4NWF A;  5HKW A;  1BM2 A;  5HKY A;  2ABL A;  1UUR A;  1O4F A;  1QAD A;  1FU6 A;  4H1O A;  1GRI A;  5GJI A;  3HCK A;  1O4K A;  1O4I A;  5AXI A;  1BHH A;  2EL8 A;  1BHF A;  2CI8 A;  2RSY A;  2EYZ A;  5EEL A;  3PJP A;  2PNB A;  4LUE A;  5IBM A;  1O4L A;  3KFJ A;  3T04 A;  2RVF A;  1JWO A;  2HMH A;  3PSK A;  1O4Q A;  1X6C A;  1O4G A;  4K11 A;  2LCT A;  5EG3 B;  4A4C A;  1CJ1 A;  4U1P A;  4A4B A;  3VS2 A;  4FL2 A;  3M7F A;  1BLK A;  3PS5 A;  3HHM B;  4LUD A;  3CD3 A;  4OHL A;  1Y1U A;  3EAC A;  1K9A A;  1HCS B;  3QWY A;  1O4A A;  1H9O A;  3VS1 A;  2EOB A;  3MAZ A;  1O47 A;  1A81 A;  3CBL A;  2VIF A;  2DM0 A;  2FO0 A;  3MXC A;  2ROR A;  4L1B B;  1OPK A;  4P9V A;  3VRR A;  2SRC A;  1AYD A;  1O4N A;  2AOB A;  1BKM A;  3S8N A;  3VRP A;  3MXY A;  2MRJ A;  2OZO A;  1FHS A;  2C0O A;  1D1Z A;  2HCK A;  1RQQ C;  1M61 A;  3CWG A;  4TZI A;  2SHP A;  4GL9 E;  5HKZ A;  2KK6 A;  2K7A B;  1O4C A;  2EO6 A;  2L4K A;  4WWQ A;  2GSB A;  1OO4 A;  4XZ1 A;  5KAZ A;  1BG1 A;  3NHN A;  1YVH A;  3VGO A;  1Y57 A;  2HDV A;  1CSZ A;  1A09 A;  1ZFP E;  1RJA A;  1O49 A;  2DLZ A;  1O44 A;  4EY0 A;  2CS0 A;  3EAZ A;  1KC2 A;  3OV1 A;  2EO3 A;  1O48 A;  2XP1 A;  1CWD L;  1OO3 A;  1NZV A;  1JYQ A;  2ETZ A;  1AOU F;  4GWF A;  1A1E A;  5DF6 A;  3TL0 A;  2H8H A;  1AYB A;  3ZNI A;  4DGP A;  5D0J A;  3BUW B;  3OVE A;  1O4R A;  2MRK A;  4OHH A;  1SHA A;  2EYY A;  1NZL A;  3OB2 B;  1LCJ A;  2QMS A;  2CR4 A;  4OHE A;  1BHH B;  3GXW A;  2HDX A;  1BKL A;  1O4D A;  2Y1M A;  2EKX A;  2OQ1 A;  3N8M A;  2LQN A;  5AUL A;  1YVL A;  3UF4 A;  1RPY A;  2IUH A;  4P9Z A;  2L3T A;  1KA7 A;  4JEG A;  5GJH A;  1F2F A;  5EHR A;  5EHP A;  2YU7 A;  1X0N A;  1BLJ A;  1SHD A;  2CIA A;  1MW4 A;  3IN7 A;  1LKL A;  3PLF B;  5J3X A;  2YSX A;  2K79 B;  3VRQ A;  1D4W A;  2AUG A;  1F1W A;  4H34 A;  2PLD A;  2CRH A;  2C0T A;  1BFJ A;  2DVJ A;  4M4Z A;  1SPR A;  2PTK A;  3PFV A;  1R1Q A;  3WA4 A;  1LKK A;  2B3O A;  1NRV A;  1JU5 A;  4XZ0 A;  1XA6 A;  4F5A A;  1P13 A;  1GHU A;  5DC0 B;  3PSJ A;  1G83 A;  1FMK A;  1TZE E;  2DCR A;  3BUN B;  3IMJ A;  4EIH A;  2LQW A;  3IN8 A;  5IBS A;  1LUM A;  5I6V A;  3VRZ A;  2LNW A;  1O4B A;  3QWX X;  4K2R A;  5EEQ A;  3OP0 A;  1O45 A;  1LCK A;  4K44 A;  3TKZ A;  5DC9 A;  1O4M A;  2IZV A;  2AOA A;  4E68 A;  2JYQ A;  1BFI A;  3N84 A;  1AYC A;  3VS7 A;  1MIL A;  4F5B A;  2H5K A;  3VS5 A;  2IUI A;  2Y3A B;  1O4P A;  2H46 E;  1O4H A;  1SPS A;  3VS0 A;  5CDW A;  1A1C A;  1AB2 A;  1O41 A;  3S8O A;  1OPL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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