1O4QA

Crystal structure of sh2 in complex with ru79256.
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
106
structure length
106
Chain Sequence
SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
total genus 26
structure length 106
sequence length 106
ec nomenclature ec 2.7.10.2: Non-specific protein-tyrosine kinase.
pdb deposition date 2003-06-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 1o4qA00
1RQQC 2IUIA 2GSBA 3OV1A 3IN7A 3TL0A 3CBLA 3IMJA 1O4AA 2LNWA 4A4BA 1QG1E 5HKYA 5DC4A 3QWXX 1JYUA 2IUHA 3PS5A 1O47A 4K45A 1A08A 4K44A 2C9WA 2Y1MA 1AYAA 4WWQA 2MK2A 4NWGA 2DM0A 5DC0B 4GL9E 1LUNA 3CXLA 1O48A 2Y3AB 2H8HA 3OVEA 2CI9A 3PQZA 4ROJA 4GWFA 1HCSB 3BUMB 2C0IA 1NZVA 4OHDA 1TCEA 3BUWB 3BUNB 1SKJA 1KA7A 1O4MA 1RPYA 4D8KA 1A1EA 1BM2A 1TZEE 3GXXA 3VRNA 1OPLA 1R1PA 2EL8A 2XP1A 3UF4A 1FYRA 4OHIA 1BKLA 1O42A 1SPRA 5DC9A 5GJHA 1KC2A 1O4QA 1LCJA 1LCKA 1O4RA 1FU5A 2LNXA 2YU7A 3VRQA 3N84A 2K79B 2OZOA 3CWGA 3EAZA 4OHEA 2B3OA 2RORA 2H5KA 4LUDA 1AOTF 1AD5A 2EYVA 4L1BB 5I6VA 1F2FA 3VS3A 3VS4A 2PLDA 1O4PA 3VS5A 1FBVA 1MILA 1SHBA 1SPSA 1CJ1A 1BHFA 1A1BA 2L6KA 1WQUA 1YVHA 3S8OA 1O4BA 1FBZA 3K2MA 5HKZA 5IBSA 1BLJA 1O46A 2FO0A 4EIHA 2CRHA 1BFJA 1O44A 3VS6A 5AULA 2DX0A 1F1WA 1LUKA 2MRJA 4JEGA 1OO4A 2HUWA 1IJRA 1A07A 4OHHA 4H34A 1R1QA 3GQIB 1A1AA 1SHDA 3NHNA 1NZLA 3US4A 1BF5A 3N8MA 4NWFA 2L3TA 2KNOA 2C0OA 3VS0A 2AOBA 3PFVA 1PICA 3OB1B 2PNBA 1FHSA 2FCIA 3BUOB 2RSYA 2LQNA 2CS0A 3OP0A 4DGXA 5BO4A 5AXIA 2PNAA 2DCRA 1A09A 2L4KA 1OO3A 2ETZA 4LUEA 1LUMA 4F5AA 2PLEA 2LQWA 2AOAA 4F59A 1XA6A 1BHHB 5EHPA 4H1OA 1I3ZA 4E68A 2CR4A 4XZ1A 2HDVA 5EEQA 1O43A 2EO3A 2HCKA 1AB2A 1O41A 3S9KA 1R1SA 2EYYA 5EHRA 1MW4A 2DLYA 2OQ1A 3N7YA 3CD3A 4GPLB 1OPKA 1X0NA 1B47A 2CIAA 3VS1A 1NRVA 1K9AA 1FMKA 1BFIA 1BG1A 1SHAA 2HDXA 4P9VA 3M7FA 1CSZA 5GJIA 2JYQA 1BHHA 1JWOA 1O4JA 1D4WA 3IN8A 1CWEA 3VS2A 1QCFA 1O4HA 3GXWA 3IMDA 1JYQA 1G83A 3TKZA 1JU5A 5D0JA 1D1ZA 3VGOA 4K2RA 1BKMA 1HCTB 1O4CA 1AOUF 5CDWA 1BLKA 2RVFA 1KSWA 2GE9A 1A1CA 1UUSA 1GRIA 4X6SA 1QADA 4M4ZA 1O4GA 2MQIA 1O49A 2IZVA 2LCTA 2EOBA 3C7IA 1P13A 3T04A 1M61A 1O4DA 3PJPA 1ZFPE 2EO6A 5EELA 4FBNA 3UYOA 2K7AB 4U1PA 1KA6A 4FL3A 1IS0A 3QWYA 2H46E 2BBUA 1O4OA 4A4CA 4QSYA 4E93A 2IUGA 3PLFB 2ABLA 3BKBA 1LKLA 1O4LA 2MC1A 3S8NA 1JYRA 3VS7A 1Y57A 3HCKA 2HMHA 3PSKA 3VRYA 5HKWA 1H9OA 1AYBA 1D4TA 3BUXB 1YVLA 2KK6A 2SRCA 4F5BA 3OB2B 2EKXA 2AUGA 5IBMA 5EG3B 3HHMB 1FU6A 1GHUA 4XZ0A 4DGPA 1Z3KA 3VRPA 2PTKA 3PSJA 3WA4A 3S8LA 1LKKA 2C0TA 2EYZA 1RJAA 4EY0A 1O4FA 4OHLA 5J3XA 3ZNIA 2DLZA 1X6CA 1AYDA 2RMXA 1BMBA 1AYCA 4K11A 2QMSA 2ECDA 1M27A 3HIZB 2CBLA 3VROA 1O4IA 4JE4A 1CWDL 1UURA 2SHPA 4TZIA 1X27A 1Y1UA 1CSYA 1A81A 1O4NA 5DF6A 1O4KA 2EU0A 3MXYA 4JGHA 3KFJA 2VIFA 1LUIA 3MAZA 3EACA 3VRZA 2DVJA 2Y1NA 2MRKA 2YSXA 2CI8A 3VRRA 3MXCA 1O45A 4P9ZA 1O4EA 4FL2A 4U17A 5KAZA
chains in the Genus database with same CATH superfamily
1RQQC 2IUIA 2GSBA 3OV1A 3IN7A 3TL0A 3CBLA 3IMJA 1O4AA 2LNWA 4A4BA 1QG1E 5HKYA 5DC4A 3QWXX 1JYUA 2IUHA 3PS5A 1O47A 4K45A 1A08A 4K44A 2C9WA 2Y1MA 1AYAA 4WWQA 2MK2A 4NWGA 2DM0A 5DC0B 4GL9E 1LUNA 3CXLA 1O48A 2Y3AB 2H8HA 3OVEA 2CI9A 3PQZA 4ROJA 4GWFA 1HCSB 3BUMB 2C0IA 1NZVA 4OHDA 1TCEA 3BUWB 3BUNB 1SKJA 1KA7A 1O4MA 1RPYA 4D8KA 1A1EA 1BM2A 1TZEE 3GXXA 3VRNA 1OPLA 1R1PA 2EL8A 2XP1A 3UF4A 1FYRA 4OHIA 1BKLA 1O42A 1SPRA 5DC9A 5GJHA 1KC2A 1O4QA 1LCJA 3LYVA 1LCKA 1O4RA 1FU5A 2LNXA 2YU7A 3VRQA 3N84A 2K79B 2OZOA 3CWGA 3EAZA 4OHEA 2B3OA 2RORA 2H5KA 4LUDA 1AOTF 1AD5A 2EYVA 4L1BB 5I6VA 1F2FA 3VS3A 3VS4A 2PLDA 1O4PA 3VS5A 1FBVA 1MILA 1SHBA 1SPSA 1CJ1A 1BHFA 1A1BA 2L6KA 2KGYA 1WQUA 1YVHA 3S8OA 1O4BA 1FBZA 3K2MA 5HKZA 5IBSA 1BLJA 1O46A 2FO0A 4EIHA 2CRHA 1BFJA 1O44A 3VS6A 5AULA 2DX0A 1F1WA 1LUKA 2MRJA 4JEGA 1OO4A 2HUWA 1IJRA 1A07A 4OHHA 4H34A 1R1QA 3GQIB 1A1AA 1SHDA 3NHNA 1NZLA 3US4A 1BF5A 3N8MA 4NWFA 2L3TA 2KNOA 2C0OA 3VS0A 2AOBA 3PFVA 1PICA 3OB1B 2PNBA 1FHSA 2FCIA 3BUOB 2RSYA 2LQNA 2CS0A 3OP0A 4DGXA 5BO4A 5AXIA 2PNAA 2DCRA 1A09A 2L4KA 1OO3A 2ETZA 4LUEA 1LUMA 4F5AA 2PLEA 2LQWA 2AOAA 4F59A 1XA6A 1BHHB 5EHPA 4H1OA 1I3ZA 4E68A 2CR4A 4XZ1A 2HDVA 5EEQA 1O43A 2EO3A 2HCKA 1AB2A 1O41A 3S9KA 1R1SA 2EYYA 5EHRA 1MW4A 2DLYA 2OQ1A 3N7YA 3CD3A 4GPLB 1OPKA 1X0NA 1B47A 2CIAA 3VS1A 1NRVA 1K9AA 1FMKA 1BFIA 1BG1A 1SHAA 2HDXA 4P9VA 3M7FA 1CSZA 5GJIA 2JYQA 1BHHA 1JWOA 1O4JA 1D4WA 3IN8A 1CWEA 3VS2A 1QCFA 1O4HA 3GXWA 3IMDA 1JYQA 1G83A 3TKZA 1JU5A 5D0JA 1D1ZA 3VGOA 4K2RA 1BKMA 1HCTB 1O4CA 1AOUF 5CDWA 1BLKA 2RVFA 1KSWA 2GE9A 1A1CA 1UUSA 1GRIA 4X6SA 1QADA 4M4ZA 1O4GA 2MQIA 1O49A 2IZVA 2LCTA 2EOBA 3C7IA 1P13A 3T04A 1M61A 1O4DA 3PJPA 1ZFPE 2EO6A 5EELA 4FBNA 3UYOA 2K7AB 4U1PA 1KA6A 4FL3A 1IS0A 3QWYA 2H46E 2BBUA 1O4OA 4A4CA 4QSYA 4E93A 2IUGA 3PLFB 2ABLA 3BKBA 1LKLA 1O4LA 2MC1A 3S8NA 1JYRA 3VS7A 1Y57A 3HCKA 2HMHA 3PSKA 3VRYA 5HKWA 1H9OA 1AYBA 1D4TA 3BUXB 1YVLA 2KK6A 2SRCA 4F5BA 3OB2B 2EKXA 2AUGA 5IBMA 5EG3B 3HHMB 1FU6A 3K2TA 1GHUA 4XZ0A 4DGPA 1Z3KA 3VRPA 2PTKA 3PSJA 3WA4A 3S8LA 1LKKA 2C0TA 2EYZA 1RJAA 4EY0A 1O4FA 4OHLA 5J3XA 3ZNIA 2LRAA 2DLZA 1X6CA 1AYDA 2RMXA 1BMBA 1AYCA 4K11A 2QMSA 2ECDA 1M27A 3HIZB 2CBLA 3VROA 1O4IA 4JE4A 1CWDL 1UURA 2SHPA 4TZIA 1X27A 1Y1UA 1CSYA 1A81A 1O4NA 5DF6A 1O4KA 2EU0A 3MXYA 4JGHA 3KFJA 2VIFA 1LUIA 3MAZA 3EACA 3VRZA 2DVJA 2Y1NA 2MRKA 2YSXA 2CI8A 3VRRA 3MXCA 1O45A 4P9ZA 1O4EA 4FL2A 4U17A 5KAZA
chains in the Genus database with same CATH topology
1RQQC 2IUIA 2GSBA 3OV1A 3IN7A 3TL0A 3CBLA 3IMJA 1O4AA 2LNWA 4A4BA 1QG1E 5HKYA 5DC4A 3QWXX 1JYUA 2IUHA 3PS5A 1O47A 4K45A 1A08A 4K44A 2C9WA 2Y1MA 1AYAA 4WWQA 2MK2A 4NWGA 2DM0A 5DC0B 4GL9E 1LUNA 3CXLA 1O48A 2Y3AB 2H8HA 3OVEA 2CI9A 3PQZA 4ROJA 4GWFA 1HCSB 3BUMB 2C0IA 1NZVA 4OHDA 1TCEA 3BUWB 3BUNB 1SKJA 1KA7A 1O4MA 1RPYA 4D8KA 1A1EA 1BM2A 1TZEE 3GXXA 3VRNA 1OPLA 1R1PA 2EL8A 2XP1A 3UF4A 1FYRA 4OHIA 1BKLA 1O42A 1SPRA 5DC9A 5GJHA 1KC2A 1O4QA 1LCJA 1LCKA 1O4RA 1FU5A 2LNXA 2YU7A 3VRQA 3N84A 2K79B 2OZOA 3CWGA 3EAZA 4OHEA 2B3OA 2RORA 2H5KA 4LUDA 1AOTF 1AD5A 2EYVA 4L1BB 5I6VA 1F2FA 3VS3A 3VS4A 2PLDA 1O4PA 3VS5A 1FBVA 1MILA 1SHBA 1SPSA 1CJ1A 1BHFA 1A1BA 2L6KA 1WQUA 1YVHA 3S8OA 1O4BA 1FBZA 3K2MA 5HKZA 5IBSA 1BLJA 1O46A 2FO0A 4EIHA 2CRHA 1BFJA 1O44A 3VS6A 5AULA 2DX0A 1F1WA 1LUKA 2MRJA 4JEGA 1OO4A 2HUWA 1IJRA 1A07A 4OHHA 4H34A 1R1QA 3GQIB 1A1AA 1SHDA 3NHNA 1NZLA 3US4A 1BF5A 3N8MA 4NWFA 2L3TA 2KNOA 2C0OA 3VS0A 2AOBA 3PFVA 1PICA 3OB1B 2PNBA 1FHSA 2FCIA 3BUOB 2RSYA 2LQNA 2CS0A 3OP0A 4DGXA 5BO4A 5AXIA 2PNAA 2DCRA 1A09A 2L4KA 1OO3A 2ETZA 4LUEA 1LUMA 4F5AA 2PLEA 2LQWA 2AOAA 4F59A 1XA6A 1BHHB 5EHPA 4H1OA 1I3ZA 4E68A 2CR4A 4XZ1A 2HDVA 5EEQA 1O43A 2EO3A 2HCKA 1AB2A 1O41A 3S9KA 1R1SA 2EYYA 5EHRA 1MW4A 2DLYA 2OQ1A 3N7YA 3CD3A 4GPLB 1OPKA 1X0NA 1B47A 2CIAA 3VS1A 1NRVA 1K9AA 1FMKA 1BFIA 1BG1A 1SHAA 2HDXA 4P9VA 3M7FA 1CSZA 5GJIA 2JYQA 1BHHA 1JWOA 1O4JA 1D4WA 3IN8A 1CWEA 3VS2A 1QCFA 1O4HA 3GXWA 3IMDA 1JYQA 1G83A 3TKZA 1JU5A 5D0JA 1D1ZA 3VGOA 4K2RA 1BKMA 1HCTB 1O4CA 1AOUF 5CDWA 1BLKA 2RVFA 1KSWA 2GE9A 1A1CA 1UUSA 1GRIA 4X6SA 1QADA 4M4ZA 1O4GA 2MQIA 1O49A 2IZVA 2LCTA 2EOBA 3C7IA 1P13A 3T04A 1M61A 1O4DA 3PJPA 1ZFPE 2EO6A 5EELA 4FBNA 3UYOA 2K7AB 4U1PA 1KA6A 4FL3A 1IS0A 3QWYA 2H46E 2BBUA 1O4OA 4A4CA 4QSYA 4E93A 2IUGA 3PLFB 2ABLA 3BKBA 1LKLA 1O4LA 2MC1A 3S8NA 1JYRA 3VS7A 1Y57A 3HCKA 2HMHA 3PSKA 3VRYA 5HKWA 1H9OA 1AYBA 1D4TA 3BUXB 1YVLA 2KK6A 2SRCA 4F5BA 3OB2B 2EKXA 2AUGA 5IBMA 5EG3B 3HHMB 1FU6A 1GHUA 4XZ0A 4DGPA 1Z3KA 3VRPA 2PTKA 3PSJA 3WA4A 3S8LA 1LKKA 2C0TA 2EYZA 1RJAA 4EY0A 1O4FA 4OHLA 5J3XA 3ZNIA 2DLZA 1X6CA 1AYDA 2RMXA 1BMBA 1AYCA 4K11A 2QMSA 2ECDA 1M27A 3HIZB 2CBLA 3VROA 1O4IA 4JE4A 1CWDL 1UURA 2SHPA 4TZIA 1X27A 1Y1UA 1CSYA 1A81A 1O4NA 5DF6A 1O4KA 2EU0A 3MXYA 4JGHA 3KFJA 2VIFA 1LUIA 3MAZA 3EACA 3VRZA 2DVJA 2Y1NA 2MRKA 2YSXA 2CI8A 3VRRA 3MXCA 1O45A 4P9ZA 1O4EA 4FL2A 4U17A 5KAZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RQQ C;  2IUI A;  2GSB A;  3OV1 A;  3IN7 A;  3TL0 A;  3CBL A;  3IMJ A;  1O4A A;  2LNW A;  4A4B A;  1QG1 E;  5HKY A;  5DC4 A;  3QWX X;  1JYU A;  2IUH A;  3PS5 A;  1O47 A;  4K45 A;  1A08 A;  4K44 A;  2C9W A;  2Y1M A;  1AYA A;  4WWQ A;  2MK2 A;  4NWG A;  2DM0 A;  5DC0 B;  4GL9 E;  1LUN A;  3CXL A;  1O48 A;  2Y3A B;  2H8H A;  3OVE A;  2CI9 A;  3PQZ A;  4ROJ A;  4GWF A;  1HCS B;  3BUM B;  2C0I A;  1NZV A;  4OHD A;  1TCE A;  3BUW B;  3BUN B;  1SKJ A;  1KA7 A;  1O4M A;  1RPY A;  4D8K A;  1A1E A;  1BM2 A;  1TZE E;  3GXX A;  3VRN A;  1OPL A;  1R1P A;  2EL8 A;  2XP1 A;  3UF4 A;  1FYR A;  4OHI A;  1BKL A;  1O42 A;  1SPR A;  5DC9 A;  5GJH A;  1KC2 A;  1O4Q A;  1LCJ A;  1LCK A;  1O4R A;  1FU5 A;  2LNX A;  2YU7 A;  3VRQ A;  3N84 A;  2K79 B;  2OZO A;  3CWG A;  3EAZ A;  4OHE A;  2B3O A;  2ROR A;  2H5K A;  4LUD A;  1AOT F;  1AD5 A;  2EYV A;  4L1B B;  5I6V A;  1F2F A;  3VS3 A;  3VS4 A;  2PLD A;  1O4P A;  3VS5 A;  1FBV A;  1MIL A;  1SHB A;  1SPS A;  1CJ1 A;  1BHF A;  1A1B A;  2L6K A;  1WQU A;  1YVH A;  3S8O A;  1O4B A;  1FBZ A;  3K2M A;  5HKZ A;  5IBS A;  1BLJ A;  1O46 A;  2FO0 A;  4EIH A;  2CRH A;  1BFJ A;  1O44 A;  3VS6 A;  5AUL A;  2DX0 A;  1F1W A;  1LUK A;  2MRJ A;  4JEG A;  1OO4 A;  2HUW A;  1IJR A;  1A07 A;  4OHH A;  4H34 A;  1R1Q A;  3GQI B;  1A1A A;  1SHD A;  3NHN A;  1NZL A;  3US4 A;  1BF5 A;  3N8M A;  4NWF A;  2L3T A;  2KNO A;  2C0O A;  3VS0 A;  2AOB A;  3PFV A;  1PIC A;  3OB1 B;  2PNB A;  1FHS A;  2FCI A;  3BUO B;  2RSY A;  2LQN A;  2CS0 A;  3OP0 A;  4DGX A;  5BO4 A;  5AXI A;  2PNA A;  2DCR A;  1A09 A;  2L4K A;  1OO3 A;  2ETZ A;  4LUE A;  1LUM A;  4F5A A;  2PLE A;  2LQW A;  2AOA A;  4F59 A;  1XA6 A;  1BHH B;  5EHP A;  4H1O A;  1I3Z A;  4E68 A;  2CR4 A;  4XZ1 A;  2HDV A;  5EEQ A;  1O43 A;  2EO3 A;  2HCK A;  1AB2 A;  1O41 A;  3S9K A;  1R1S A;  2EYY A;  5EHR A;  1MW4 A;  2DLY A;  2OQ1 A;  3N7Y A;  3CD3 A;  4GPL B;  1OPK A;  1X0N A;  1B47 A;  2CIA A;  3VS1 A;  1NRV A;  1K9A A;  1FMK A;  1BFI A;  1BG1 A;  1SHA A;  2HDX A;  4P9V A;  3M7F A;  1CSZ A;  5GJI A;  2JYQ A;  1BHH A;  1JWO A;  1O4J A;  1D4W A;  3IN8 A;  1CWE A;  3VS2 A;  1QCF A;  1O4H A;  3GXW A;  3IMD A;  1JYQ A;  1G83 A;  3TKZ A;  1JU5 A;  5D0J A;  1D1Z A;  3VGO A;  4K2R A;  1BKM A;  1HCT B;  1O4C A;  1AOU F;  5CDW A;  1BLK A;  2RVF A;  1KSW A;  2GE9 A;  1A1C A;  1UUS A;  1GRI A;  4X6S A;  1QAD A;  4M4Z A;  1O4G A;  2MQI A;  1O49 A;  2IZV A;  2LCT A;  2EOB A;  3C7I A;  1P13 A;  3T04 A;  1M61 A;  1O4D A;  3PJP A;  1ZFP E;  2EO6 A;  5EEL A;  4FBN A;  3UYO A;  2K7A B;  4U1P A;  1KA6 A;  4FL3 A;  1IS0 A;  3QWY A;  2H46 E;  2BBU A;  1O4O A;  4A4C A;  4QSY A;  4E93 A;  2IUG A;  3PLF B;  2ABL A;  3BKB A;  1LKL A;  1O4L A;  2MC1 A;  3S8N A;  1JYR A;  3VS7 A;  1Y57 A;  3HCK A;  2HMH A;  3PSK A;  3VRY A;  5HKW A;  1H9O A;  1AYB A;  1D4T A;  3BUX B;  1YVL A;  2KK6 A;  2SRC A;  4F5B A;  3OB2 B;  2EKX A;  2AUG A;  5IBM A;  5EG3 B;  3HHM B;  1FU6 A;  1GHU A;  4XZ0 A;  4DGP A;  1Z3K A;  3VRP A;  2PTK A;  3PSJ A;  3WA4 A;  3S8L A;  1LKK A;  2C0T A;  2EYZ A;  1RJA A;  4EY0 A;  1O4F A;  4OHL A;  5J3X A;  3ZNI A;  2DLZ A;  1X6C A;  1AYD A;  2RMX A;  1BMB A;  1AYC A;  4K11 A;  2QMS A;  2ECD A;  1M27 A;  3HIZ B;  2CBL A;  3VRO A;  1O4I A;  4JE4 A;  1CWD L;  1UUR A;  2SHP A;  4TZI A;  1X27 A;  1Y1U A;  1CSY A;  1A81 A;  1O4N A;  5DF6 A;  1O4K A;  2EU0 A;  3MXY A;  4JGH A;  3KFJ A;  2VIF A;  1LUI A;  3MAZ A;  3EAC A;  3VRZ A;  2DVJ A;  2Y1N A;  2MRK A;  2YSX A;  2CI8 A;  3VRR A;  3MXC A;  1O45 A;  4P9Z A;  1O4E A;  4FL2 A;  4U17 A;  5KAZ A; 
#chains in the Genus database with same CATH topology
 1RQQ C;  2IUI A;  2GSB A;  3OV1 A;  3IN7 A;  3TL0 A;  3CBL A;  3IMJ A;  1O4A A;  2LNW A;  4A4B A;  1QG1 E;  5HKY A;  5DC4 A;  3QWX X;  1JYU A;  2IUH A;  3PS5 A;  1O47 A;  4K45 A;  1A08 A;  4K44 A;  2C9W A;  2Y1M A;  1AYA A;  4WWQ A;  2MK2 A;  4NWG A;  2DM0 A;  5DC0 B;  4GL9 E;  1LUN A;  3CXL A;  1O48 A;  2Y3A B;  2H8H A;  3OVE A;  2CI9 A;  3PQZ A;  4ROJ A;  4GWF A;  1HCS B;  3BUM B;  2C0I A;  1NZV A;  4OHD A;  1TCE A;  3BUW B;  3BUN B;  1SKJ A;  1KA7 A;  1O4M A;  1RPY A;  4D8K A;  1A1E A;  1BM2 A;  1TZE E;  3GXX A;  3VRN A;  1OPL A;  1R1P A;  2EL8 A;  2XP1 A;  3UF4 A;  1FYR A;  4OHI A;  1BKL A;  1O42 A;  1SPR A;  5DC9 A;  5GJH A;  1KC2 A;  1O4Q A;  1LCJ A;  3LYV A;  1LCK A;  1O4R A;  1FU5 A;  2LNX A;  2YU7 A;  3VRQ A;  3N84 A;  2K79 B;  2OZO A;  3CWG A;  3EAZ A;  4OHE A;  2B3O A;  2ROR A;  2H5K A;  4LUD A;  1AOT F;  1AD5 A;  2EYV A;  4L1B B;  5I6V A;  1F2F A;  3VS3 A;  3VS4 A;  2PLD A;  1O4P A;  3VS5 A;  1FBV A;  1MIL A;  1SHB A;  1SPS A;  1CJ1 A;  1BHF A;  1A1B A;  2L6K A;  2KGY A;  1WQU A;  1YVH A;  3S8O A;  1O4B A;  1FBZ A;  3K2M A;  5HKZ A;  5IBS A;  1BLJ A;  1O46 A;  2FO0 A;  4EIH A;  2CRH A;  1BFJ A;  1O44 A;  3VS6 A;  5AUL A;  2DX0 A;  1F1W A;  1LUK A;  2MRJ A;  4JEG A;  1OO4 A;  2HUW A;  1IJR A;  1A07 A;  4OHH A;  4H34 A;  1R1Q A;  3GQI B;  1A1A A;  1SHD A;  3NHN A;  1NZL A;  3US4 A;  1BF5 A;  3N8M A;  4NWF A;  2L3T A;  2KNO A;  2C0O A;  3VS0 A;  2AOB A;  3PFV A;  1PIC A;  3OB1 B;  2PNB A;  1FHS A;  2FCI A;  3BUO B;  2RSY A;  2LQN A;  2CS0 A;  3OP0 A;  4DGX A;  5BO4 A;  5AXI A;  2PNA A;  2DCR A;  1A09 A;  2L4K A;  1OO3 A;  2ETZ A;  4LUE A;  1LUM A;  4F5A A;  2PLE A;  2LQW A;  2AOA A;  4F59 A;  1XA6 A;  1BHH B;  5EHP A;  4H1O A;  1I3Z A;  4E68 A;  2CR4 A;  4XZ1 A;  2HDV A;  5EEQ A;  1O43 A;  2EO3 A;  2HCK A;  1AB2 A;  1O41 A;  3S9K A;  1R1S A;  2EYY A;  5EHR A;  1MW4 A;  2DLY A;  2OQ1 A;  3N7Y A;  3CD3 A;  4GPL B;  1OPK A;  1X0N A;  1B47 A;  2CIA A;  3VS1 A;  1NRV A;  1K9A A;  1FMK A;  1BFI A;  1BG1 A;  1SHA A;  2HDX A;  4P9V A;  3M7F A;  1CSZ A;  5GJI A;  2JYQ A;  1BHH A;  1JWO A;  1O4J A;  1D4W A;  3IN8 A;  1CWE A;  3VS2 A;  1QCF A;  1O4H A;  3GXW A;  3IMD A;  1JYQ A;  1G83 A;  3TKZ A;  1JU5 A;  5D0J A;  1D1Z A;  3VGO A;  4K2R A;  1BKM A;  1HCT B;  1O4C A;  1AOU F;  5CDW A;  1BLK A;  2RVF A;  1KSW A;  2GE9 A;  1A1C A;  1UUS A;  1GRI A;  4X6S A;  1QAD A;  4M4Z A;  1O4G A;  2MQI A;  1O49 A;  2IZV A;  2LCT A;  2EOB A;  3C7I A;  1P13 A;  3T04 A;  1M61 A;  1O4D A;  3PJP A;  1ZFP E;  2EO6 A;  5EEL A;  4FBN A;  3UYO A;  2K7A B;  4U1P A;  1KA6 A;  4FL3 A;  1IS0 A;  3QWY A;  2H46 E;  2BBU A;  1O4O A;  4A4C A;  4QSY A;  4E93 A;  2IUG A;  3PLF B;  2ABL A;  3BKB A;  1LKL A;  1O4L A;  2MC1 A;  3S8N A;  1JYR A;  3VS7 A;  1Y57 A;  3HCK A;  2HMH A;  3PSK A;  3VRY A;  5HKW A;  1H9O A;  1AYB A;  1D4T A;  3BUX B;  1YVL A;  2KK6 A;  2SRC A;  4F5B A;  3OB2 B;  2EKX A;  2AUG A;  5IBM A;  5EG3 B;  3HHM B;  1FU6 A;  3K2T A;  1GHU A;  4XZ0 A;  4DGP A;  1Z3K A;  3VRP A;  2PTK A;  3PSJ A;  3WA4 A;  3S8L A;  1LKK A;  2C0T A;  2EYZ A;  1RJA A;  4EY0 A;  1O4F A;  4OHL A;  5J3X A;  3ZNI A;  2LRA A;  2DLZ A;  1X6C A;  1AYD A;  2RMX A;  1BMB A;  1AYC A;  4K11 A;  2QMS A;  2ECD A;  1M27 A;  3HIZ B;  2CBL A;  3VRO A;  1O4I A;  4JE4 A;  1CWD L;  1UUR A;  2SHP A;  4TZI A;  1X27 A;  1Y1U A;  1CSY A;  1A81 A;  1O4N A;  5DF6 A;  1O4K A;  2EU0 A;  3MXY A;  4JGH A;  3KFJ A;  2VIF A;  1LUI A;  3MAZ A;  3EAC A;  3VRZ A;  2DVJ A;  2Y1N A;  2MRK A;  2YSX A;  2CI8 A;  3VRR A;  3MXC A;  1O45 A;  4P9Z A;  1O4E A;  4FL2 A;  4U17 A;  5KAZ A; 
#chains in the Genus database with same CATH homology
 1RQQ C;  2IUI A;  2GSB A;  3OV1 A;  3IN7 A;  3TL0 A;  3CBL A;  3IMJ A;  1O4A A;  2LNW A;  4A4B A;  1QG1 E;  5HKY A;  5DC4 A;  3QWX X;  1JYU A;  2IUH A;  3PS5 A;  1O47 A;  4K45 A;  1A08 A;  4K44 A;  2C9W A;  2Y1M A;  1AYA A;  4WWQ A;  2MK2 A;  4NWG A;  2DM0 A;  5DC0 B;  4GL9 E;  1LUN A;  3CXL A;  1O48 A;  2Y3A B;  2H8H A;  3OVE A;  2CI9 A;  3PQZ A;  4ROJ A;  4GWF A;  1HCS B;  3BUM B;  2C0I A;  1NZV A;  4OHD A;  1TCE A;  3BUW B;  3BUN B;  1SKJ A;  1KA7 A;  1O4M A;  1RPY A;  4D8K A;  1A1E A;  1BM2 A;  1TZE E;  3GXX A;  3VRN A;  1OPL A;  1R1P A;  2EL8 A;  2XP1 A;  3UF4 A;  1FYR A;  4OHI A;  1BKL A;  1O42 A;  1SPR A;  5DC9 A;  5GJH A;  1KC2 A;  1O4Q A;  1LCJ A;  1LCK A;  1O4R A;  1FU5 A;  2LNX A;  2YU7 A;  3VRQ A;  3N84 A;  2K79 B;  2OZO A;  3CWG A;  3EAZ A;  4OHE A;  2B3O A;  2ROR A;  2H5K A;  4LUD A;  1AOT F;  1AD5 A;  2EYV A;  4L1B B;  5I6V A;  1F2F A;  3VS3 A;  3VS4 A;  2PLD A;  1O4P A;  3VS5 A;  1FBV A;  1MIL A;  1SHB A;  1SPS A;  1CJ1 A;  1BHF A;  1A1B A;  2L6K A;  1WQU A;  1YVH A;  3S8O A;  1O4B A;  1FBZ A;  3K2M A;  5HKZ A;  5IBS A;  1BLJ A;  1O46 A;  2FO0 A;  4EIH A;  2CRH A;  1BFJ A;  1O44 A;  3VS6 A;  5AUL A;  2DX0 A;  1F1W A;  1LUK A;  2MRJ A;  4JEG A;  1OO4 A;  2HUW A;  1IJR A;  1A07 A;  4OHH A;  4H34 A;  1R1Q A;  3GQI B;  1A1A A;  1SHD A;  3NHN A;  1NZL A;  3US4 A;  1BF5 A;  3N8M A;  4NWF A;  2L3T A;  2KNO A;  2C0O A;  3VS0 A;  2AOB A;  3PFV A;  1PIC A;  3OB1 B;  2PNB A;  1FHS A;  2FCI A;  3BUO B;  2RSY A;  2LQN A;  2CS0 A;  3OP0 A;  4DGX A;  5BO4 A;  5AXI A;  2PNA A;  2DCR A;  1A09 A;  2L4K A;  1OO3 A;  2ETZ A;  4LUE A;  1LUM A;  4F5A A;  2PLE A;  2LQW A;  2AOA A;  4F59 A;  1XA6 A;  1BHH B;  5EHP A;  4H1O A;  1I3Z A;  4E68 A;  2CR4 A;  4XZ1 A;  2HDV A;  5EEQ A;  1O43 A;  2EO3 A;  2HCK A;  1AB2 A;  1O41 A;  3S9K A;  1R1S A;  2EYY A;  5EHR A;  1MW4 A;  2DLY A;  2OQ1 A;  3N7Y A;  3CD3 A;  4GPL B;  1OPK A;  1X0N A;  1B47 A;  2CIA A;  3VS1 A;  1NRV A;  1K9A A;  1FMK A;  1BFI A;  1BG1 A;  1SHA A;  2HDX A;  4P9V A;  3M7F A;  1CSZ A;  5GJI A;  2JYQ A;  1BHH A;  1JWO A;  1O4J A;  1D4W A;  3IN8 A;  1CWE A;  3VS2 A;  1QCF A;  1O4H A;  3GXW A;  3IMD A;  1JYQ A;  1G83 A;  3TKZ A;  1JU5 A;  5D0J A;  1D1Z A;  3VGO A;  4K2R A;  1BKM A;  1HCT B;  1O4C A;  1AOU F;  5CDW A;  1BLK A;  2RVF A;  1KSW A;  2GE9 A;  1A1C A;  1UUS A;  1GRI A;  4X6S A;  1QAD A;  4M4Z A;  1O4G A;  2MQI A;  1O49 A;  2IZV A;  2LCT A;  2EOB A;  3C7I A;  1P13 A;  3T04 A;  1M61 A;  1O4D A;  3PJP A;  1ZFP E;  2EO6 A;  5EEL A;  4FBN A;  3UYO A;  2K7A B;  4U1P A;  1KA6 A;  4FL3 A;  1IS0 A;  3QWY A;  2H46 E;  2BBU A;  1O4O A;  4A4C A;  4QSY A;  4E93 A;  2IUG A;  3PLF B;  2ABL A;  3BKB A;  1LKL A;  1O4L A;  2MC1 A;  3S8N A;  1JYR A;  3VS7 A;  1Y57 A;  3HCK A;  2HMH A;  3PSK A;  3VRY A;  5HKW A;  1H9O A;  1AYB A;  1D4T A;  3BUX B;  1YVL A;  2KK6 A;  2SRC A;  4F5B A;  3OB2 B;  2EKX A;  2AUG A;  5IBM A;  5EG3 B;  3HHM B;  1FU6 A;  1GHU A;  4XZ0 A;  4DGP A;  1Z3K A;  3VRP A;  2PTK A;  3PSJ A;  3WA4 A;  3S8L A;  1LKK A;  2C0T A;  2EYZ A;  1RJA A;  4EY0 A;  1O4F A;  4OHL A;  5J3X A;  3ZNI A;  2DLZ A;  1X6C A;  1AYD A;  2RMX A;  1BMB A;  1AYC A;  4K11 A;  2QMS A;  2ECD A;  1M27 A;  3HIZ B;  2CBL A;  3VRO A;  1O4I A;  4JE4 A;  1CWD L;  1UUR A;  2SHP A;  4TZI A;  1X27 A;  1Y1U A;  1CSY A;  1A81 A;  1O4N A;  5DF6 A;  1O4K A;  2EU0 A;  3MXY A;  4JGH A;  3KFJ A;  2VIF A;  1LUI A;  3MAZ A;  3EAC A;  3VRZ A;  2DVJ A;  2Y1N A;  2MRK A;  2YSX A;  2CI8 A;  3VRR A;  3MXC A;  1O45 A;  4P9Z A;  1O4E A;  4FL2 A;  4U17 A;  5KAZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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